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Biomedical Research in the Ncat Century 289
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-r’- .ot.it’:. ‘).11v )l1’0: hit, ‘ ‘Jt iflt ‘fl\ i’tt)’(’fl) flttftJOt’ fw : “q. 0 rnh’, o L ‘0 si iepO’i’ fnvt’ c ‘sorked ;“it .s hrr’ th. OU1s arc.m 11w three hmens’n’’aI tro r’ ‘it .id 21 .. t’, iiia:iy protem,arts. I his ariking pmgicss is lie csult 01 sI Ikhes .1rt ied cuit by thou—aixls i( ‘stWilt isis. each hmldmg i in the knowledge accu inulated 1w:heir predecessors intl published ip scientific journals The km wledge)Ot’i it’t 1 . a me m Ph ma ti (Icier t I iclds of 1 iS cst igal 1011. md it wa‘ft:i.aiatJ a ci inpet led wn% to pro Iu.e a sigm ficant ads ante.Some at this ping; ess mvoi’ ed the des dopment o new me boils.whii h 1 P 0011 gre1ii Is’ ITO. reased ‘hr speed 1 ml poss er of the cthat (olhn\ed.Figure 3 presents a highly sc.heniatic comparison of the earlyprogress of my field dtft side) with the much more rapid progress thatis being made tod,iv (right side The p It ‘ ‘tell” iting prrmarily‘‘t’t lost’ ‘I I .nge rcrc’asc’ os h i lull ,i’,t’l ‘‘ ‘eies’alit st; irfic( lit fls’tedfft’ I hat an be . otuhint ci n new st’,iv’z 11, ‘‘.tle n’clathc’ruaucalR Petc’ ‘c m i’s plusne m n’ H ‘a the o1s’hihes a r ‘s n;’ie I (it’ Ws •‘ ‘ ri !‘dgc . air c ombined 1ii I ,00hiimcs more was s than to units of knowledge can. Even scientists seemurprised by the modern explosion of scientific progress ouId theot )( t his slirpi jse be nor fit i’i’ t
(itt’ ‘I lIv ‘‘ic 0011 termluitive power of coinbinatorics?
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Figure 33.1. The Accelerating Pace of BiomedIcal Research.
Bk medical Research in the Nat Castwy
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- oilabot ations hat ewloit ‘IR uiihque skIls of each—- it von wish the‘ower of I he cunln n;i 0 ‘nab pri Fit ipie when appl ‘ed to loomed 4)1research laboratories.Today, s i ch c’ ii lahora t ;on are i ‘erhaps nit ‘st tom own ‘a hen niielaboratory is expert in a highi> specialized technique, such as X—raycrystallography, and the other laborator pros ides the biological mate -ml to be .nlaiy7ed h- I hat methodology-. Hut in the turui e. sot tic’ is p-’of interialit ratorv olfahoration i,’ tikels’ t’ hec oO)e the rar-tdard rtue for nearls’ ill hiog-fit ,il ‘qs”’stigaflons ‘s ‘r --pe alk r l:’In(tant c’sample it we are
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!Jicnnedicai Research in the Next Gmtury 293
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tmv! iiccd ! hat umc p 4% err ur I vpc 1 }unrnedkai neLl 3:emerge.
When pmmot ing these new connections between scientists we‘1¾ ‘)lt’lii. \ic-Ji •lJ ‘¾. i ‘ols IIC :IWtTtI
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and basic researchers.The same . mild bt caid [or many other areas of hii,medit a]
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I imp comdhe regularly sponsored by the National Instil tiles of I iealth, each
chaired hy a distinguished clink ian and a distinguished basic sci —
- 1. The a L endees r t the rn’ - might be I nv ited to c.orn pete in‘qutal —
294 CRITICAL ISSUES IN GLOBAL HEALTH
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pinned. Finding a solution is a crint a! task for the twenty- first ten—
urv— md a hallenge to our uruversitles, ,ui haritabh t(ltLndziiHmc,tnd tir t crnment tundin agtr’t. trs
A MAJOR ROLE FOR GROWTh FACTORSP1 THE TREATMENT OF DISEASE
I now come to part of the chapter where I stick my ned out in’l ncfuture enib-it ‘assment. I Jere I shall extrapolate mom my eight
‘S B tltinteet tenti Iit ads 1st 1 to ltc cler - rtna
;eseaich I ouidation, nut and inspired by oinan .s ith the ,ii easc,
m \It tnk; I hase learned that there are maii3’ debilitating humant •eases. I ‘tustet atus origin, that lead to the dcgene’itton of t
U it t issue ‘r et Ill tissues, and often result in death - I hese -
- s-entualh anse an abnormal immune response and for thist hey arc often classified as “atitoimmune hseaes.”
I [owever, treatments that suppress the immune response have no
.‘fte.t on the fundamental course of many of these diseases, suggest
m hat a 1n ‘duciton ‘if cpet di self iitthtnhies u, .tf1’ t, r ,ith’ ‘han
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Biomedkaikn.cch La the Ntc: 295
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