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Human Endocrine Human Endocrine PhysiologyPhysiology
February 27, 2014
Sex DeterminationSex Determinationand Differentiationand Differentiation
SRY
SRY
AMH T
SRY GeneSRY Gene
Testicular Steroid Testicular Steroid PathwaysPathways
Progesterone
Pregnenolone
Cholesterol
17OH-Prog
17OH-Preg
T
A4
LH/FSH
Conversion of TestosteroneConversion of Testosteroneto Dihydrotestosteroneto Dihydrotestosterone
SRY
AMH T
Conversion of TestosteroneConversion of Testosteroneto Dihydrotestosteroneto Dihydrotestosterone
Adrenal Steroid PathwaysAdrenal Steroid Pathways
Progesterone
Pregnenolone
Cholesterol
Cortisol
17OH-Prog
17OH-Preg DHEA
Testosterone
Androstenedione
Aldosterone
ACTH
Classical Congenital Adrenal Classical Congenital Adrenal HyperplasiaHyperplasia
Progesterone
Pregnenolone
Cholesterol
Cortisol
17OH-Prog
17OH-Preg DHEA
Testosterone
Androstenedione
Aldosterone
ACTH
*
*21-hydroxylase loss of function mutation
*
Classical Congenital Adrenal Classical Congenital Adrenal HyperplasiaHyperplasia
Progesterone
Pregnenolone
Cholesterol
Cortisol
17OH-Prog
17OH-Preg DHEA
Testosterone
Androstenedione
Aldosterone
ACTH
*
*21-hydroxylase loss of function mutation
*
Human Endocrine Physiology:Human Endocrine Physiology:The Menstrual CycleThe Menstrual Cycle
Ovarian PhysiologyOvarian Physiology
GnRH
Pituitary
Ovary
LH
FSHInhibin
EstrogensProgesterone Androgens
FSHSex steroidInhibin*
+
Gonadotropin Releasing Hormone (GnRH)
+
(pituitary)
(hypothalamus)
(ovary)
LH-(+)
*Inhibin exerts negative feedback only at the pituitary and only on FSH
Insulin
Ovarian Steroid PathwaysOvarian Steroid Pathways
Progesterone
Pregnenolone
Cholesterol
17OH-Prog
17OH-Preg
T
A4
LH/FSH
Estrone
Estradiol
*Only enzyme to know
* *
Changes in HormonesChanges in HormonesAcross the Menstrual CycleAcross the Menstrual Cycle
0 Ov 30
FSH
Changes in HormonesChanges in HormonesAcross the Menstrual CycleAcross the Menstrual Cycle
0 Ov 30
Estradiol
Changes in HormonesChanges in HormonesAcross the Menstrual CycleAcross the Menstrual Cycle
0 Ov 30
LH
Changes in HormonesChanges in HormonesAcross the Menstrual CycleAcross the Menstrual Cycle
0 Ov 30
Progesterone
Inhibin
**
*LH receptors on granulosa cells induced by FSH
Changes in HormonesChanges in HormonesAcross the Menstrual CycleAcross the Menstrual Cycle
0 Ov 30
Inhibin
Inhibin
**
*LH receptors on granulosa cells induced by FSH
Functions of FSHFunctions of FSHDuring the Menstrual CycleDuring the Menstrual Cycle
Functions of LHFunctions of LHDuring the Menstrual CycleDuring the Menstrual Cycle
Functions of EstradiolFunctions of EstradiolDuring the Menstrual CycleDuring the Menstrual Cycle
Functions of ProgesteroneFunctions of ProgesteroneDuring the Menstrual CycleDuring the Menstrual Cycle
Functions of InhibinFunctions of InhibinDuring the Menstrual CycleDuring the Menstrual Cycle
Changes in HormonesChanges in HormonesAcross the Menstrual CycleAcross the Menstrual Cycle
0 Ov 30
