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Chemistry Institute of Tajikistan Academy of Sciences 299/2 Ainy str., 734063 Dushanbe, Tajikistan tel/fax: 992 372258095, mobil: 992 934884843 E-mail: muhidinovzayniddin@gmail.com; web: www.ikai.tj

Forum-2018, ECTAP

New Technological Process include flash

Hydrolysis & Extraction (A) of pectin from

fruits pulps and dynamics mode for sunflower

head residues (B). Technological line include

dia-ultrafiltration method for purification and

concentrate of pectin solution (C).

Advantage over traditional methods– low

acid pH and contact time during extraction 5-

10 min instead of 60-120 min. Highly quality

of extracted pectin. Process exclude vacuum

evaporation and use of large quantity of

alcohol

The technology is protected by 2 patents in

Tajikistan, 1 Eurasian and 2 Industrial Model

in Ukraine

The advantage of C technique over typical

process and other patents (DE 3041096 A1,

EP 0426431 A1) was proved in the

experimental pectin workshop of PAPO

“Shahrinav”, Tajikistan

The technological line of A & C and B & C

were tested in the Pilot Plan using different

local raw materials (Appendix 1).

New Process

Low energy consumption

Easy retrofitting and low

maintenance

Low cost product

Ecological friendly, reliability

and productivity of process

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Advantages of Technique of A,B, C:

Low Pectin Price;

Flexible technology;

Easy retrofitting and low maintenance ;

Low energy consumption;

Ecological friendly, reagent less,

reliability and productivity of process.

Citrus pectin-CP Kelco, Denmark,

Apple pectin-Herbstreith & Fox KG, Germany

Fruit Pectin-Technological line combining

process A &C

Sunflower pectin-Technological line

combining process B &C

Competitive advantageous over Traditionally technology for

Pectin production :

Shortcomings of competitors:

High price;

Time consumption;

Large quantities of expensive and

inflammable settling alcohol;

High consumption of electric power for

evaporation and spirit regeneration;

Ecological problem- explosive spirit and

vacuum installation.

Citrus pectin-Danisco Ingredients USA Inc.

Forum 2018, ECTAP

HM Pectin –

Jams and Jelly

68%

Characteristics of Commercial Pectin

Food additive (code # 440 & E440)

DE>50 - high methoxy (HM)

• rapid, medium or slow set (RS, MS, SS)

DE<50 - low methoxy

• conventional (LMC)

• low methoxy amidated(LMA)

Several grades marketed for

different applications

2003

2013

Exhibition 2018, NCPI RT

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Total global market, 2016 60,000 tonnes CIC countries market 4,500 tonnes LM pectin (~15%) ~5,000 tonnes Overall growth rate 7,1% LM pectin 10-20% Current price (US$) HM: 11.00/kg LM: 12.90/kg

Application Growth Rate

Fruit preparations 15 –20% Fruit spreads (low sugar jams) 10% + Yoghurt and dairy 15 –20% Acidified milk drinks, high-sugar jams

2 –5%

Fruit juices & high calcium drinks 10 –15% Baked goods, confectionary 5% Fat replacers 20% +

The global pectin market [http://www.grandviewresearch.com/industry-analysis/pectin-market ]is expected to reach USD 1.9 billion by 2025, according to a new report by Grand View Research, Inc.

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Production of LM Pectin: Traditional R-COOMe+ H2O →R-COOH + MeOH

aq. acid or aq. acid/org. solvent

aq. alkali (other than amidation)

enzymic

Main natural sources Sunflower (pectin-20-25%,

GA>65%)

Pumpkin (10-15%, GA >60%)

Peach (15-20%, GA >65%)

Some special applications

Reduced/low sugar jams & jellies

Heat reversible jams, jellies &

fillings

Baking stable fruit preparations

Cold setting milk jellies

Fruit preparations for yoghurt

Control of fruit separation: HM +

LM.

Peach Pectin (Prunus persica) Powder, 10 kg (22 lbs): RF--$522

Пектин превращает еду в наслаждение

Forum 2018, ECTAP 7

Food Prophylactic

products ( Functional &

diet)

BioActive Additives

OTC

Non-prescription medication

Drug form

Pharmaceuticals

• Colon-specific drug delivery systems

(are more effective and reproducible

in comparison with other delivery

systems).

• utilized in a number of liquid

pharmaceutical preparations.

• Anti-diarrhea suspensions,

• Pectin is extensively used as a

component in the adhesive part of

ostomy rings,

• Pectin composites as cartilage

replacers

Medicine • Pectin, excret lipids, cholesterol and bile

acids, and reduce serum cholesterol levels.

• Pectin has anti-diarrhea effect.

• Pectin acts as an antioxidant against the

damaging portion of cholesterol in the blood

stream.

• Prevent colon cancer.

• Pectin increase acidity (pH) in the large

intestines, suffering from ulcer or colitis, and

regulating blood pressure.

• Pectin prevent gallstones.

• Regular use of Pectin may lessen the

severity of diabetes.

Fibersol Caps -(200 Capsules),Twinlab- $19 MCP (Modified Citrus Pectin) 360 grams -

Vital Nutrients - $132 Allergy Research Group Modified Citrus Pectin

Pwd 16oz -$115

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A new drug delivery system (DDS) based on pectin/protein in form of hydrogels and microcapsules in emulsion are developed.

The hydrogel drug delivery form based on the pectin and corn zein

The microcapsules tailored on different pectin & Whey Lg concentrate.

Both therapeutic systems may withstand high temperature and pH, to protect active drug, aroma and flavor.

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Drug Delivery Technology Market worth 1,669.40 Billion USD by 2021

Global Forecast to 2021", Drug delivery technology market is projected to reach USD

1,669.40 Billion by 2021 from USD 1,179.20 Billion in 2016, at a CAGR of 7.2% during

the forecast period.

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1. Jonmurodov, A., Bobokalonov, J., Usmanova, S.,

Muhidionоv Z.K., and Liu, L.S. Agricultural Sciences,

2017, vol.8, p.857-867.

2. Shamsara O., Jafari S. M., Muhidinov Z.K. Journal of

Biological Macromolecules, 103(2017), p. 1285-1293.

3. DjonmurodovA.S., Muhidinov Z.K., Strahan G.D., Kholov

S.E., Teshaev Kh.I., Fishman M.L., Liu LS. In Gums and

Stabilisers for Food Industry 16. / Ed. by Peter A. Williams

and Glyn O. Philips.-RSC Publishing 2016. P. 23-36.

4. Muhidinov Z.K., Teshaev Kh.I, Kasimova G. F.,

Nasriddinov A.S., Liu LS. Pectin-Zein Hydrogels for

delivery of Drugs and Nutrients. In Gum and Stabilisers for

the Food Industry 16, RSC publishing, Cambridge UK.

2012, p. 401-406.Shamsara O., Jafari S.M.,

5. Muhidionv Z.K. Development of double layered emulsion

droplets with pectin/ β-lactoglobulin complex for bioactive

delivery purposes. Journal of Molecular Liquid, 2017, 243,

6. Shamsara O., Muhidinov Z.K., Jafari S.M., Bobokalonov

J., et al. International Journal of Biological

Macromolecules, 81(2015), p. 1019-1025.

7. Z.K. Muhidinov, J.D. Bobokalonov, L.S. Liu, and R.

Fassihi. A Kinetic Study of Poor Water Soluble Drug

Released from Pectin Microcapsules Using

Diffusion/Dissolution Model ACS Symposium series 2008,

No. 992 s, Chapter 11, p. 193-208.

8. Z.K. Muhydinov, D.Kh. Khalikov, T. Speaker and R.

Fassihi. Development and characterization of different low

methoxy pectin microcapsules by an emulsion – interface

reaction technique. Journal of Microencapsulation. 2004

vol. 21 (7), p. 729-741.

Piroxicam release kinetics from

the Zein/pectin hydrogel

microspheres at ex vivo

experiments.

Ex Vivo Piroxicam fraction

released cures for

microcapsules prepared with

the LM APSh pectins:

LgC/Pectin ratio 18; volume

of emulsion containing

cecum content in dialysis

Piroxicam plasma concentration

released from microcapsules of

LgC/LM Apple pectin. In vivo

experiments; mean SD, n= 6.

0.0

0.1

0.2

0.3

0.4

0.5

0.6

0.7

0.8

0.9

0 5 10 15 20 25 30 35t, hours

Mt/

Mo

0

0,1

0,2

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0,6

0,7

0,8

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Mt/

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Z/APSH 1,0 Z/CPK L/200 1,0

PX plasma

concentration

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ml

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• Nasal drug delivery (транспорт ЛВ через органов дыхания)

• Oral drug delivery (пероральная) • Cancer-targeted drug delivery (транспорт в

раковых клеток) • Pectin polyplexes for gene delivery

(Polyplex-Биаксиально ориентированной пленки ПЭТ (BOPET) успешно используется в различных областях, благодаря отличной комбинации оптических, физических, механических, термических и химических свойств.

• Ocular drug delivery (носителей для глазных каплей)

• Pectin gels for tissue engineering (пектиновые гели для тканевых инженерии)

Pectin gels as wound healing

patches (гели для заживление ран)

• Функциональная пища

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Thank you very much!