http://www.invivogen.com/review-engineered-pfuse-chigEngineered
Fc Regions Review- 2011Engineering Fc regions for altered
properties
The Fc region of an antibody mediates its serum half-life and
effector functions, such as complement-dependent cytotoxicity
(CDC), antibody-dependent cellular cytotoxicity (ADCC) and
antibody-dependent cell phagocytosis (ADCP).Engineering the Fc
regionof a therapeutic monoclonal antibodyor Fc fusion protein
allows the generation of molecules that are better suited to the
pharmacology activity required of them [1].Engineered Fc regions
for increased half-lifeOne approach to improve the efficacy of
atherapeutic antibodyis to increase its serum persistence, thereby
allowing higher circulating levels, less frequent administration
and reduced doses.
The half-life of an IgG depends on its pH-dependent binding to
the neonatal receptor FcRn (=Fc receptor=Brambell receptor)*.* In
humans, it is found in the placenta to help facilitate transport of
mother's IgG to the growing fetus and it has also been shown to
play a role in monitoring IgG turnover. FcRn binds IgG at acidic pH
of (
