FARMAKOLOGI OBAT MATA

SJARIF ISMAILLABORATORIUM FARMAKOLOGI

FK-UNMUL

Farmakologi Obat Mata:

Obat glaukoma Conjunctivitis & keratitis Tear Deficiency/Dry Eyes

Aqueous Humor Production

GLAUCOMA

Differential Diagnosis for Red Eyes

Mekanisme Kerja Antimikroba

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--LactamLactam CompoundCompound Other Other --LactamLactam GroupGroup GlycopeptideGlycopeptide AntibioticsAntibiotics Other Cell or Other Cell or MembranMembran Active AgentsActive Agents

Classification Classification AntimicobialAntimicobial AgentsAgents Target Target MembranMembran Cell WallCell Wall

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Classification Classification AntimicobialAntimicobial AgentsAgents Target Protein synthesisTarget Protein synthesis

TetracylinesTetracylines MacrolidesMacrolides LyncosamideLyncosamide ClindamycinClindamycin StreptograminsStreptogramins QuinupristinQuinupristin--dalfoprisindalfoprisin ChloramphenicolChloramphenicol OxazolidinonesOxazolidinones LinezolidiLinezolidi AminoglycosidesAminoglycosides

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Bactericidal Bactericidal vsvs BacteriostaticBacteriostatic

Bactericidal:Bactericidal: PenicillinsPenicillins CephalosporinsCephalosporins CarbapenemsCarbapenems MonobactamsMonobactams GlycopeptideGlycopeptide LipopeptideLipopeptide StreptograminsStreptogramins CotrimoxazolCotrimoxazol FluoroquinolonesFluoroquinolones RifampicinRifampicin INHINH

BacteriostaticBacteriostatic:: TetracyclinesTetracyclines MacrolidesMacrolides LincosamideLincosamide ChloramphenicolChloramphenicol OxazolidinonesOxazolidinones AminoglicosidesAminoglicosides PyrazinamidePyrazinamide EthambutolEthambutol

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--LactamLactam compounds:compounds: Substituted 6Substituted 6--aminopenicillanic acid aminopenicillanic acid

Penicillin, Penicillin, AntistaphylococalAntistaphylococal penicillin, penicillin, AminopenicillinsAminopenicillins, , AntipseudoAntipseudo. . penicillinspenicillins

Substituted 7Substituted 7--aminocephalosporanic acid aminocephalosporanic acid CephalosporinCephalosporin

Substituted 3Substituted 3--aminoamino--44--methylmonobactamic methylmonobactamic acid acid AztreonamAztreonam

Substituted 3Substituted 3--OHOH--ethylcarbapenemic acid ethylcarbapenemic acid CarbapenemCarbapenem..

Other Other --LactamLactam Drugs: Drugs: MonobactamMonobactam AztreonamAztreonam -Lactamase inhibitor

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66--aminopenicillanic acidaminopenicillanic acid Penicillin: Penicillin:

Penicillin G (Penicillin G Penicillin G (Penicillin G benzathinebenzathine dandan procainprocain), ),

PencillinPencillin V.V. AntistaphylococalAntistaphylococal penicillin: penicillin:

IsoxazolylIsoxazolyl penicillinspenicillins: : OxacillinOxacillin, , cloxacillincloxacillin, , dicloxacillindicloxacillin oraloral

NafcillinNafcillin parenteralparenteral AminopencillinsAminopencillins: : AmpicillinAmpicillin. . amoxillinamoxillin AntipseudomonalAntipseudomonal penicillinspenicillins::

CarboxypenicillinsCarboxypenicillins: : carbenicillincarbenicillin, , ticarcillinticarcillin UreidopenicillinsUreidopenicillins: : mezlocillinmezlocillin, , piperacillinpiperacillin

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77--aminocephalosporanic acidaminocephalosporanic acid Cephalosporin Cephalosporin generasigenerasi I:I:

CephalexinCephalexin, , cefadroxilcefadroxil, , cefazolincefazolin, , cephradinecephradine Cephalosporin Cephalosporin generasigenerasi II:II:

CefoxitinCefoxitin, , cefaclorcefaclor, , cefuroximecefuroxime, , cefprozilcefprozil, , CefotetanCefotetan, , ceforanideceforanide, , LoracarbelLoracarbel

Cephalosporin Cephalosporin generasigenerasi III:III: CefotaximeCefotaxime, , CeftriaxoneCeftriaxone, , CefpodoximeCefpodoxime, , cefiksim, cefiksim, CeftibutenCeftibuten, , CefdinirCefdinir, , CefditorenCefditoren, , CeftizoximeCeftizoxime, , CefoperazoneCefoperazone, , CeftazidimeCeftazidime

Cephalosporin Cephalosporin generasigenerasi IV:IV: CefepimeCefepime

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33--OHOH--ethylcarbapenemic acidethylcarbapenemic acid

CarbapenemsCarbapenems:: ImipenemImipenem MeropenemMeropenem ErtapenemErtapenem

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--LactamaseLactamase inhibitorsinhibitors ClavulanicClavulanic acid: (acid: (biasanyabiasanya

dikombinasikandikombinasikan dengandengan amoxillinamoxillin ((CoamoxiclavCoamoxiclav), ), TicarcillinTicarcillin ((TimentinTimentin))

SulbactamSulbactam: : biasanyabiasanya dikombinasikandikombinasikan dengandengan ampicillinampicillin ((UnasynUnasyn))

TazobactamTazobactam: : biasanyabiasanya dikombinasikandikombinasikan dengandengan piperacillinpiperacillin ((ZosynZosyn))

MonobactamMonobactam

AztreonamAztreonam: stable to many : stable to many --laktamaselaktamase

May be used to May be used to treathtreath the patient with a the patient with a history of penicillin anaphylaxis history of penicillin anaphylaxis

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GlycopeptideGlycopeptide antibioticsantibiotics

VancomycinVancomycin TeicopaninTeicopanin DalbavancinDalbavancin TelavancinTelavancin

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Other Cell Wall or Other Cell Wall or MembranMembran--Active AgentsActive Agents

DaptomycinDaptomycin FosfomycinFosfomycin BacitracinBacitracin daridari Bacillus Bacillus subtilissubtilis CycloserinCycloserin daridari StreptomycesStreptomyces

orchidaceusorchidaceus

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AminoglycosidesAminoglycosides StreptomycinStreptomycin GentamycinGentamycin TobramycinTobramycin AmikacinAmikacin NetilmicinNetilmicin KanamycinKanamycin Neomycin: Neomycin: peroralperoral absorbsiabsorbsi burukburuk, , tidaktidak

digunakandigunakan secarasecara parenteralparenteral

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MacrolidesMacrolides SpiramycinSpiramycin RoxitromycinRoxitromycin ErythromycinErythromycin ClarithromycinClarithromycin AzithromycinAzithromycin TelithromycinTelithromycin

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QuinolonesQuinolones & & FluoroquinolonesFluoroquinolones

NalidixicNalidixic acidacid CinoxacinCinoxacin CiprofloxacinCiprofloxacin OfloxacinOfloxacin NorfloxacinNorfloxacin SparfloxacinSparfloxacin

FleroxacinFleroxacin PefloxacinPefloxacin LevofloxacinLevofloxacin GarenoxacinGarenoxacin GemifloxacinGemifloxacin GatifloxacinGatifloxacin

FARMAKOLOGI OBAT MATAFarmakologi Obat Mata:Slide Number 3Aqueous Humor ProductionSlide Number 5Slide Number 6Slide Number 7Slide Number 8Slide Number 9GLAUCOMASlide Number 11Slide Number 12Slide Number 13Slide Number 14Slide Number 15Slide Number 16Slide Number 17Slide Number 18Slide Number 19Slide Number 20Slide Number 21Slide Number 22Slide Number 23Slide Number 24Slide Number 25Slide Number 26Slide Number 27Differential Diagnosis for Red EyesSlide Number 29Slide Number 30Slide Number 31Mekanisme Kerja AntimikrobaClassification Antimicobial AgentsTarget Membran Cell WallClassification Antimicobial AgentsTarget Protein synthesisBactericidal vs BacteriostaticSlide Number 366-aminopenicillanic acid7-aminocephalosporanic acid3-OH-ethylcarbapenemic acid-Lactamase inhibitorsGlycopeptide antibioticsOther Cell Wall or Membran-Active AgentsAminoglycosidesMacrolidesQuinolones & FluoroquinolonesSlide Number 46Slide Number 47Slide Number 48Slide Number 49Slide Number 50Slide Number 51Slide Number 52Slide Number 53Slide Number 54Slide Number 55Slide Number 56Slide Number 57Slide Number 58Slide Number 59Slide Number 60Slide Number 61Slide Number 62Slide Number 63Slide Number 64Slide Number 65Slide Number 66Slide Number 67Slide Number 68Slide Number 69Slide Number 70Slide Number 71Slide Number 72Slide Number 73Slide Number 74