Faculty Mentors

Faculty in the Emory Division of Pulmonary, Allergy, Critical Care and Sleep Medicine have a long history of working closely with students, residents and fellows on scholarly projects. While not exhaustive, the list below should provide a sense of the breadth of faculty within the Emory Division of Pulmonary, Allergy, Critical Care and Sleep Medicine who are available to serve as mentors, their areas of research interest, and a list of recent projects on which they have worked with trainees. All of these faculty are very enthusiastic about working with trainees in a mentoring capacity.

Sara Auld, MD, MSCR Assistant Professor of Medicine My research interests are focused around the global TB and HIV epidemics. I have extensive experience in the clinical epidemiology of TB, drug-resistant TB, and TB/HIV coinfection. More recently, I have also begun to explore various aspects of lung health in TB infection, including lung immunology and pulmonary impairment during and after TB

infection. I would be happy to meet with trainees about potential projects and explore any interests in these areas.

Recent Publications:

Research Roadmap for Tuberculosis Transmission Science: Where Do We Go From Here and How Will We Know When We're There?, Auld SC, Kasmar AG, Dowdy DW, Mathema B, Gandhi NR, Churchyard GJ, Rustomjee R, Shah NS. J Infect Dis. 2017 Nov 3;216(suppl_6):S662-S668

Transmission of Extensively Drug-Resistant Tuberculosis in South Africa. Shah NS, Auld SC, Brust JC, Mathema B, Ismail N, Moodley P, Mlisana K, Allana S, Campbell A, Mthiyane T, Morris N, Mpangase P, van der Meulen H, Omar SV, Brown TS, Narechania A, Shaskina E, Kapwata T, Kreiswirth B, Gandhi NR. N Engl J Med. 2017 Jan 19;376(3):243-253.

IFN-” Release Assay Result Is Associated with Disease Site and Death in Active Tuberculosis. Auld SC, Lee SH, Click ES, Miramontes R, Day CL, Gandhi NR, Heilig CM. Ann Am Thorac Soc. 2016 Dec;13(12):2151-2158.

Mixed impact of Xpert(®) MTB/RIF on tuberculosis diagnosis in Cambodia. Auld SC, Moore BK, Kyle RP, Eng B, Nong K, Pevzner ES, Eam KK, Eang MT, Killam WP. Public Health Action. 2016 Jun 21;6(2):129-35.

Rollout of Xpert(®) MTB/RIF in Northwest Cambodia for the diagnosis of tuberculosis among PLHA. Auld SC, Moore BK, Killam WP, Eng B, Nong K, Pevzner EC, Eam KK, Eang MT, Warren D, Whitehead SJ. Public Health Action. 2014 Dec 21;4(4):216-21.

Tuberculin skin test result and risk of death among persons with active TB. Auld SC, Click ES, Heilig CM, Miramontes R, Cain KP, Bisson GP, Mac Kenzie WR. PLoS One. 2013 Nov 11;8(11):e78779.

Association between tuberculin skin test result and clinical presentation of tuberculosis disease. Auld SC, Click ES, Heilig CM, Miramontes R, Cain KP, Bisson GP, Mac Kenzie WR. BMC Infect Dis. 2013 Oct 4;13:460.

Nancy A. Collop, MD Professor of Medicine and Neurology Director, Emory Sleep Center Director, Sleep Medicine Fellowship I came to Emory in 2010 from Johns Hopkins, where I was director of the Johns Hopkins Hospital Sleep Laboratory. I

am the director of the Emory Sleep Center, which is an independent cost center and part of Emory Healthcare and Emory University. The Emory Sleep Center moved to Executive Park in February 2015. The Emory Sleep Center has 9 faculty members, and includes 9 sleep laboratory bedrooms, home sleep apnea testing and has its own durable medical equipment program. In 2012, we initiated our sleep medicine fellowship program which has 3 fellows per year.

My area of scholarly interest is in diagnosing and treatment of sleep disorders with a special interest in sleep disordered breathing. I am interested in new technologies to diagnose and monitor sleep and sleep disorders. My other passion is to continue to enhance our

sleep medicine fellowship program to attract the best and brightest residents and fellows to our program, particularly those with academic interests.

Research Papers with mentees

• Fraser CL, Bliwise DL, Newman NJ, Lamirel C, Collop NA, Rye DB, Trotti LM, Biousse V, Bruce BB. A Prospective Photographic Study of the Ocular Fundus in Obstructive Sleep Apnea. J Neuroophthalmol. 2013;33(3):241-6.

• Kamdar B, King L, Collop N, Sakimuri S, Colantuoni E, Neufeld K,Bienvenu J, Rowden A, Touradji P, Brower R, Needham D. The effect of a quality improvement intervention on perceived sleep quality and cognition in a medical ICU. Critical Care Med 2013; 41(3):800-9.

• Salas RE, Gamaldo A, Collop NA, Gulyani S, Hsu M, David PM, Rao A, Gamaldo CE. A step out of the dark: improving the sleep medicine knowledge of trainees. Sleep Med. 2013;14(1):105-8.

• Wickwire E, Smith M, Collop N. Sleep Maintenance Insomnia Complaints Predict Poor CPAP Adherence: A Clinical Case Series Sleep Medicine. Sleep Medicine 2010; 11(8):772-776

• Krishnan V, McCormack M, Mathai S, Agarwal S, Horton M, Polito A, Collop N, Danoff S.Ô Sleep Quality and Health Related Quality of Life in Idiopathic Pulmonary Fibrosis.Chest 2008;134(4):693-8.

• Stierer T, Wright C, George A, Thompson R, Wu C, Collop N. Risk Assessment of Obstructive Sleep Apnea in a Population of patients undergoing Outpatient Surgery. Journal of Clinical Sleep Medicine 2010 ;6(5):467-72.

• Marcus C, Trois M, McMelendres F, Schwartz A, Collop N, Capone G. Obstructive sleep apnea in Down syndrome. Journal of Clinical Sleep Medicine 2009;5(4):317-323.

Recent reviews / book chapters with mentees

• Allam S, Collop N. Obesity-Hypoventilation Syndrome. In Clinical Decision Support: PULMONARY MEDICINE, edited by Drs. Grippi, Heffner, and Kotloff. 2013 (https://www.decisionsupportinmedicine.com/DSM/a/program/28)

• Allam S, Collop N. Central Sleep Apnea Syndrome. In Clinical Decision Support: PULMONARY MEDICINE, Editors: Grippi, Heffner, Kotloff. 2013 (https://www.decisionsupportinmedicine.com/DSM/a/program/28)

• Peters M,Collop N. Diagnosis of Obstructive Sleep Apnea.Ô In Obstructive Sleep Apnea. Editor: Levy P. Future Science Group, London. 2013

• Hoff S, Collop N. Sleep disorders and recovery from critical illness.Ô In The Legacy of Critical Care. Editors: Drs Stevens, Hart, Herridge. Oxford University Press, Oxford, England 2013.

• Kim S, Collop N.Cost of Therapy. In Obstructive Sleep Apnea; Sleep Medicine Clinics, Volume 8, Issue 4; 557-569.Ô Editors:Ô S. Jones, J. Barker. Elsevier Inc, Philadelphia, PA 2013

• Gomes O, Collop N. Obstructive sleep apnea: Epidemiology and Pathogenesis. In Primary Care Sleep Medicine: A Practical Guide. Editors: J.F. Pagel, S.R. Pandi-Perumal (eds.), Springer Science+Business, Media New York 2014 (doi: 10.1007/978-1-4939-1185-1_11)

• Young D, Collop N.Ô Advances in the treatment of obstructive sleep apnea. Curr Treat Options Neurol 2014;16(8):305.(doi: 10.1007/s11940-014-0305-6)

Other recent manuscripts

• Kamdar BB, Niessen T, Colantuoni E, King LM, Neufeld KJ, Bienvenu OJ, Rowden AM, Collop NA, Needham DM” Delirium transitions in the medical ICU: exploring the role of sleep quality and other factors. Crit Care Med. 2015 Jan;43(1):135-41

• Aurora RN, Collop NA, Jacobowitz O, Thomas SM, Quan SF, Aronsky AJ. Quality measures for the care of adult patients with obstructive sleep apnea J Clin Sleep Med. 2015 Mar 15;11(3):357-83

• Colvin L, Collop N. Commercial motor vehicle driver obstructive sleep apnea screening and treatment in the US: An update and recommendation overview. A. J Clin Sleep Med 2015 (Epub ahead of print)

• Foldvary-Schaefer N, Kaw R, Collop N, Andrews ND, Bena J, Want L, Stierer T, Gillinoz M, Tarler M, Kayyali H. Prevalence of undetected sleep apnea in patients undergoing cardio vascular surgery and impact on postoperative outcomes. J Clin Sleep Med 2015 Jun11 (Epub ahead of print)

• Colvin L, Cartwright A, Collop N, Freedman N, McLeod D, Weaver TE, Rogers AE. Advanced practice registered nurses and physician assistants in sleep centers and clinics: a survey of current roles and educational background. A.” J Clin Sleep Med. 2014 May 15;10(5):581-7.

Sushma K. Cribbs, MD, MSc Associate Professor of Medicine Associate Program Director, Pulmonary and Critical Care Medicine Fellowship Staff Physician, Atlanta VA Medical Center After completing residency and fellowship at Emory University, I joined the faculty at Emory in 2009. After joining the

faculty, I was primarily based at Grady Memorial Hospital where I conducted clinical research and attending on the Pulmonary Consult Service and Medical Intensive Care Unit. I obtained a NIH Clinical Research Loan Repayment grant at the end of fellowship and maintained consistent funding until 2013, when I moved to the Atlanta VA. In 2011, I was awarded a KL2 grant and completed a Masters of Science and Clinical Research through Emory Rollins School of Public Health with a focus on clinical-translational research on the HIV-lung, and investigating mechanistic pathways by which HIV impairs lung host immunity. I am currently a staff physician at the Atlanta VA, where I attend on Pulmonary Consults and the MICU services. I have continued investigations in the field of HIV lung disease through several clinical trials which have now expanded to other areas of interesting including metabolomics, lung microbiome, Mycobacterium Tuberculosis, and other chronic lung diseases such as chronic obstructive lung disease (COPD). These projects have broad implications for our understanding of how we can limit the consequences of HIV on the lung, and decrease the lung-specific morbidity and mortality for individuals living with HIV despite adherence to anti-retroviral therapy.

I am also the Associate Program Director for the Pulmonary & Critical Care Medicine Fellowship Program and as such am very involved in the teaching and mentoring of our fellows. I have also mentored undergraduate, graduate and post-graduate trainees at Emory University both in clinical and scientific arenas. In addition, I currently participate and Chair a number of committees both in the Department of Medicine, the School of Medicine and in national and regional scientific societies such as the American Thoracic Society and the Southern Society of Clinical Investigation.

Recent publications and projects with mentees:

1. CC Polito, SK Cribbs, GS Martin, T O'Keeffe, D Herr, TW Rice, JE Sevransky . “Navigating the Institutional Review Board Approval Process in a Multicenter Observational Critical Care Study”. Crit Care Med. 2013 Dec 23. PMID: 24368345.

2. JE Han, SK Cribbs, GS Martin (2015). “Sepsis, Severe Sepsis and Septic Shock”. In JB Hall, GA Schmidt, and JP Kress (Eds), Principles of Critical Care, Fourth Edition (562-75). USA; the McGraw-Hill Companies, Inc.

3. SK Cribbs, Y Park, DM Guidot, GS Martin, LA Brown, J Lennox, DP Jones. “Metabolomics of Bronchoalveolar Lavage Differentiate Healthy HIV-1-Infected Subjects from Controls”. AIDS Res Hum Retroviruses. 2014 Feb 10. PMID: 24417396.

4. SK Cribbs, DM Guidot, GS Martin, J Lennox, LA Brown. “Anti-Retroviral Therapy Is Associated with Decreased Alveolar Glutathione Levels Even in Healthy HIV-Infected Individuals”. PLOS One. 2014 Feb 12; 9(2):e88630. PMID: 24533122.

5. S. Prebil, J Andrews, SK Cribbs, GS Martin and AM Esper. “Safety of Research Bronchoscopy in Critically Ill Patients” J Crit Care. 2014 Jun 13. PMID: 25092617.

6. SK Cribbs, J Lennox, AM Caliendo, LA Brown, DM Guidot. “Healthy HIV-1-Infected Individuals on HAART Harbor HIV-1 in their Alveolar Macrophages” AIDS Res Hum Retroviruses. 2014 Aug 18: 25134819.

7. A Chaudhry, R Neuman,SK Cribbs. “Bedside Critical Care Echocardiography Revealing an Unsuspected Diagnosis”. Chest. 2014; 146: 891A.

8. *S Yeligar, DM Guidot, LA Brown, and SK Cribbs. “HIV infection induces NADPH oxidase expression in alveolar macrophages of otherwise healthy subjects”. Am J Respir Crit Care Med 191; 2015: A4720.

9. F Nirappil , A Maheshwari, J Andrews, GS Martin, AM Esper, SK Cribbs. “Characteristics and Outcomes of HIV-1-infected Patients with Acute Respiratory Distress Syndrome” J Crit Care. 2015 Feb; 30(1):60-4. PMID: 25466320.

10. SK Cribbs, C Tse, J Andrews, N Shenvi, GS Martin. “Characteristics and Outcomes of HIV-infected Patients with Severe Sepsis: Continued Risk in the Post-HAART Era” Crit Care Med. 2015 Apr 6. PMID: 25853590.

11. SK Cribbs, K Uppal, S Li, DP Jones, L Huang, L Tipton, A Fitch, R Greenblatt, L Kingsley, DM Guidot, E Ghedin, A Morris. “Correlation of the Lung Microbiota with Metabolic Profiles in Bronchoalveolar Lavage Fluid in HIV Infection”. Microbiome. 2016 Jan 20, 4(1):3. PMID: 26792212.

12. SK Cribbs and AP Fontenot. “The Impact of Antiretroviral Therapy on Lung Immunology”. Seminars in Respiratory and Critical Care Medicine. 2016:37:2. Semin Respir Crit Care Med. 2016 Apr;37(2):157-65. PMID: 26974295.

13. SK Cribbs and JM Beck. “Microbiome in the pathogenesis of cystic fibrosis and lung transplant-related disease”. Transl Res. Accepted April 2016

Lisa Daniels, MD Assistant Professor of Medicine Assistant Program Director, Critical Care Medicine Fellowship Clerkship Director, Critical Care Medicine

Dr. Daniels joined faculty in 2017. Her main research interests are in the areas of medical education, ultrasound and simulation. Her research is focused on development and use of low fidelity procedural models used in the education of medical trainees. Current models include central line access, arterial line access, dialysis line access, extra-corporeal cardiopulmonary membrane oxygenation (ECMO) access, thoracentesis and chest tube placement.

She also has an interest in quality improvement with a focus on improving efficiency in processes and systems that are time sensitive, including massive blood transfusions and extra-corporeal cardiopulmonary resuscitation (ECPR). Other areas of interest include improving the assessment and management of intensive care unit delirium and post intensive care syndrome.

Recent research projects with mentees

- Richard Ramonell MD, Meredith Greer MD, Matthew Schimmel: Sonographic-based Training Analogue Built for Insertion and Guidance of Residents and Interns Training Evaluation (STABInG RITE)

- Richard Ramonell MD, Matthew Wiepking MD, Ashley Binder MD: Low-fidelity gelatin models in the use of procedural simulation training for extra-corporeal cardiopulmonary membrane oxygenation (ECMO) access placement

- Matthew Reaven MD: Teacher or learner: Evaluating the ability of self-directed procedural simulation training in attending physicians

Recent publications

1. Daniels, L.M., et al., Impact of time to antibiotic on hospital stay, intensive care unit admission, and mortality in febrile neutropenia. Support Care Cancer, 2019.

2. Nasim, F., et al., Practical Implementation of Failure Mode and Effects Analysis for Extracorporeal Membrane Oxygenation Activation. Am J Med Qual, 2018. 33(5): p. 523-529.

3. Daniels, L.M., et al., Characterizing Potentially Preventable Admissions: A Mixed Methods Study of Rates, Associated Factors, Outcomes, and Physician Decision-Making. J Gen Intern Med, 2018. 33(5): p. 737-744.

4. Daniels, L.M., et al., Pharmacologic Treatment of Intensive Care Unit Delirium and the Impact on Duration of Delirium, Length of Intensive Care Unit Stay, Length of Hospitalization, and 28-Day Mortality. Mayo Clin Proc, 2018. 93(12): p. 1739-1748.

5. Daniels, L.M., et al., Improving Quality of Life in Patients at Risk for Post-Intensive Care Syndrome. Mayo Clin Proc Innov Qual Outcomes, 2018. 2(4): p. 359-369.

6. Daniels, L.M., et al., Extremely Elevated Erythrocyte Sedimentation Rates: Associations With Patients' Diagnoses, Demographic Characteristics, and Comorbidities. Mayo Clin Proc, 2017. 92(11): p. 1636-1643.

7. Daniels, L.M., et al., Failure mode and effects analysis to reduce risk of anticoagulation levels above the target range during concurrent antimicrobial therapy. Am J Health Syst Pharm, 2015. 72(14): p. 1195-203.

8. Daniels, L.M., J.N. Barreto, and P.K. Tosh, Supratherapeutic international normalized ratios in warfarin-treated patients who receive a highly potentiating antimicrobial course. JAMA Intern Med, 2014. 174(7): p. 1200

Annette Esper, MD Assistant Professor of Medicine

Dr. Esper joined the faculty at Emory in 2008, primarily based at Grady Memorial Hospital, where she conducted clinical research and attend on the Pulmonary consult service and in the Medical Intensive Care Unit. After joining the faculty, she obtained my Masters of Science in Clinical Research (MSCR) from Emory and since then she has served on

the Thesis Committee for multiple MSCR students in addition to mentoring MSCR students. In addition to her work with post-graduate trainees (residents and fellows), she also serves on the Medical Student Research Committee and has worked with medical students on Discovery Phase projects.

Her research interests include clinical and translational research in critically ill patients, with a specific interest in sepsis and the acute respiratory distress syndrome (ARDS). Currently, her work focuses on translational research in sepsis-induced ARDS, where she is

investigating the role of alveolar macrophage function and phenotype, and conducting biomarker and metabolomics studies in ARDS. She has also conducted and collaborated on work that includes epidemiology research, observational studies, and randomized, controlled trials in critically ill patients.

Recent research projects with mentees

• Ralitza Martin, MD (pulmonary fellow): Role of metabolomics in sepsis-induced • Ralitza Martin, MD (pulmonary fellow): The RAGE axis in sepsis-induced • Sarah Prebil, MD (past resident): The safety of bronchoscopy in critically ill patients

Recent reviews/book chapters with mentees

• Martin R, Esper A, Martin GS. Hematologic Complications. Non-Pulmonary Complications of Critical Care. Richards JB and Stapleton RD (eds.) New York, NY. Springer New York, 2014.

Other recent manuscripts

• Nirappil FJ, Maheshwari A, Andrews J, Martin GS, Esper AM, Cribbs SK.Ô Characteristics and outcomes of HIV-1 infected patient with acute respiratory distress syndrome. A” J Crit Care. 2015 Feb;30(1):60-4. Oct 30. PMID:25466320.

• Prebil S, Andrews J, Cribbs S, Martin GS and Esper AM. Safety of Research Bronchoscopy on Critically Ill Patients. A. J Crit Care 2014; 29(6):961-4.Ô PMID: 25092617.

Charles J. Grodzin, MD Assistant Professor of Medicine Pulmonary, Critical Care, Allergy and Sleep Medicine

I came to Emory in July 2014. I have a strong background in general pulmonary medicine and attend clinical services at Emory University Hospital Midtown in the outpatient clinic as well as the pulmonary medical consult service and in

the medical 71 ICU. I am the current medical director of the Respiratory Care Department. I am a member of the EUHM Pulmonary Embolism Response Team specifically handling Pulmonary Embolism consultations and developing a pulmonary embolism clinic . I am also a member of multiple quality committees at EUHM.

Into my third full year of my academic career, I am pleased to continue to find enjoyment and satisfaction in sharing my pulmonary and critical care experience with medical students, residents and fellows as we share complex clinical scenarios. I continue to enjoy honing my skills in the educational spotlight both clinically at the bedside and in more traditional didactic settings via lecture or interactive board review style presentations and the creation of new and exciting patient care opportunities. For me it is a joy to share my career experiences and spend time with those in training. In addition, I feel energized by the opportunity to participate in clinical research that affects directly the way we practice on a daily basis. I look to expand my clinical horizons further as opportunities arise.

At this point, I am available to work with students, residents and fellows in the development of teaching and clinical research projects. My goals are to add to the knowledge base, bring therapy to the bedside and share findings for use for the greater medical good. I would love to hear fresh ideas for clinical investigation, novel project or to work with students or trainees to develop projects that are based on their particular interests.

David M. Guidot, MD Jeffrey R. Pine Chaired Professor of Medicine Director, Division of Pulmonary, Allergy, Critical Care & Sleep Medicine I joined the faculty at Emory University as an assistant professor in 1995 following four years of fellowship training and three years on the faculty at the University of Colorado. I had no meaningful research training prior to my fellowship

but dedicated three years to laboratory-based research as a fellow and it has been a major facet of my professional activity ever since. My early research focused on basic mechanisms of oxidative stress and has evolved over the years into two related areas; specifically, the effects of chronic alcohol abuse and HIV on lung health. I direct basic laboratory projects in the Whitehead Biomedical Research Building as well as clinical translational projects at the Atlanta VA and Grady. I remain active as a clinician and teaching attending physician as I love clinical medicine and, at least for me, I believe that I am a better clinician because of the intellectual rigor required to do research. Conversely, my research is always in a clinical context because of my active medical practice.

In my twenty years at Emory my greatest passion has been mentoring students, residents and fellows in both clinical medicine and in biomedical research. Â I have mentored more than twenty post-doctoral fellows (including both MD and PhD trainees) and many more residents and students. As a co-director of a training grant from the NIH, this mentoring includes having minority medical students from Morehouse each summer. In parallel, I have mentored Emory medical students through the Discovery Phase program and literally dozens of medical residents have performed research electives with me. Over the years I have lost count of how many have presented at regional or national meetings, but it must be fifty or more.

For students and residents doing short-term research experiences I focus on instilling a sense of how medical research progresses; specifically, how to ask and answer important questions. Although there is always an element of learning some investigative techniques, the focus is on the intellectual approach and the excitement of pursuing new (and often unexpected) findings. Trainees working with me and my collaborators can work on projects anywhere along the research spectrum, from cell culture to animal models to clinical trials. I know first-hand the value of a positive research experience with mentors who taught me to `think and question’ and not just `learn techniques’. My greatest thrill is when a student, resident or fellow gets excited about their research project and presents it at a meeting and/or helps publish the work as a co-author. Although many of my trainees are now actively pursuing academic careers as physician-scientists, many are in clinical academic positions or private practice. I consider all of them to be great successes.

Recent students and residents I mentored:

• Nnamdi Azih -current Morehouse medical student • Eric Kerchberger -Emory medical student and now a resident in emergency medicine at Ohio State • Thomas Middour -Emory medical student and now a medicine resident at Tulane • Mohita Singh -Emory medical student and now a medicine resident at Baylor • Victor Tseng -Emory resident and now a pulmonary fellow at Colorado • Rich Ramonell -current Emory resident • Jeff Talbot -current Emory resident

Current physicians I am mentoring: Viranuj Sueblinvong, MD (Emory faculty member)

• Sueblinvong V, Kerchberger VE (Emory medical student), Saghafi R, Mills ST, Fan X, Guidot DM: Chronic alcohol ingestion primes the lung for bleomycin-induced fibrosis in mice. Alcoholism: Clinical and Experimental Research. 2014 Feb;38(2):336-43. PMID: 24033682 PMCID: PMC3869877

• Sueblinvong V, Neveu WA, Neujahr DC, Mills ST, Rojas M, Roman J, Guidot DM: Aging promotes pro-fibrotic matrix production and increases fibrocyte recruitment during acute lung injury. Adv Biosci Biotechnol. 2014 Jan;5(1):19-30. PMID: 24596659 PMCID: PMC3939026

• Sueblinvong V, Tseng V (Emory resident), Smith T, Mills, ST, Neujahr DC and Guidot DM: TGFß1 mediates alcohol-induced Nrf2 suppression in lung fibroblasts. Alcoholism: Clinical and Experimental Research. 2014 Nov;38(11):2731-42. PMID: 25421510 PMCID: PMC4244649

Sushma Cribbs, MD, MSc (Emory resident, fellow and now assistant professor)

• Cribbs SK, Guidot DM, Martin GS, Lennox J, Brown LA: Anti-retroviral therapy is associated with decreased alveolar glutathione levels even in healthy HIV-infected individuals. PLoS One. 2014 Feb 12;9(2):e88630. PMID: 24533122 PMCID: PMC3922940

• Cribbs SK, Park Y, Guidot DM, Martin GS, Brown LA, Lennox J, Jones DP: Metabolomics of Bronchoalveolar Lavage Differentiate Healthy HIV-1-Infected Subjects from Controls. AIDS Res Hum Retroviruses. 2014 Feb 10. PMID: 24417396 PMCIDÂ Â Â PMC4046199.

• Cribbs SK, Lennox J, Caliendo AM, Brown LA and Guidot DM: Healthy HIV-1-Infected Individuals on Highly Active Antiretroviral Therapy Harbor HIV-1 in Their Alveolar Macrophages. AIDS Res Hum Retroviruses. 2015 Jan;31(1):64-70. PMID:25134819 PMCID: PMC4287110

Ashish Mehta, MD, MSc (Emory resident, fellow and now assistant professor)

• Mehta, A.J., Joshi, P.C., Fan, X, Brown, L.S., Ritzenthaler, J.D., Roman, J. and Guidot, D.M.: Zinc supplementation restores PU.1 and Nrf2 nuclear binding in alveolar macrophages and improves redox balance and bacterial clearance in the lungs of alcohol-fed rats. Alcoholism: Clinical and Experimental Research. 2011 Aug;35(8):1519-28. PMCID:PMC3128659

• Mehta, AJ, Yeligar, SM, Elon, L, Brown, LA and Guidot, DM: Alcoholism Causes Alveolar Macrophage Zinc Deficiency and Immune Dysfunction. American Journal of Respiratory and Critical Care Medicine. 2013 Jun 27; PMID: 23805851 PMCID: PMC3826184

• Alcohol Use Disorders and the Lung: A Clinical and Pathophysiological Approach; Mehta, AJ and Guidot, DM editors- 2013 Springer Science, NY, NY.

Bashar Staitieh, MD (Emory fellow and joined the faculty 9-1-2015)

• Fan, X, Staitieh, BS, Jensen, JS, Mould, KJ, Greenberg, JA, Joshi, PC, Koval, M and Guidot, DM: Activating the Nrf2-mediated antioxidant response element restores barrier function in the alveolar epithelium of HIV-1 transgenic rats.- Am. J. Physiol: Lung Cell Mol Physiol. 305(3):L267-277, 2013 PMID: 23748533 PMCID: PMC3743010

• Staitieh BS, Fan X, Neveu W, Guidot DM: Nrf2 Regulates PU.1 Expression and Activity in the Alveolar Macrophage. Am J Physiol Lung Cell Mol Physiol. 2015 May 15;308(10):L1086-93. PMID: 25840997 PMCID: PMC4437011

• Staitieh B and Guidot, DM: Noninfectious Pulmonary Complications of Human Immunodeficiency Virus Infection. American Journal of the Medical Sciences. Â 2014 Dec;348(6):502-11. PMID: 24992395 PMCID: PMC4242118

Wendy Neveu, MD, PhD (Emory resident and now fellow)

• Sueblinvong V, Neveu WA, Neujahr DC, Mills ST, Rojas M, Roman J, Guidot DM: Aging promotes pro-fibrotic matrix production and increases fibrocyte recruitment during acute lung injury. Adv Biosci Biotechnol. 2014 Jan;5(1):19-30. PMID: 24596659 PMCID: PMC3939026

Ed Egea, MD (Emory resident and now fellow)

Jenny Han, MD, MSc Assistant Professor of Medicine

Dr. Han, who was born in Philadelphia, completed her undergraduate at Northwestern University and began her caregiving career as a substance abuse counselor for teenage girls. She went on to become an EMT and paramedic before attending medical school at Ross University. She graduated with highest honors and then trained in internal

medicine at Henry Ford Hospital in Detroit, going on to become chief resident. During her residency Dr. Han conducted a medical education study for which she received the David C. Leach Award from the Accreditation Council for Graduate Medical Education in 2010. She completed fellowship training in pulmonary and critical care medicine at Emory University, where she served as chief fellow. In addition, she obtained her master's degree in science at Emory Rollins School of Public Health. Currently, she works at Grady Memorial Hospital. Dr. Han actively participates in teaching medical students, residents and fellows at Emory. Dr. Han's translational and clinical research career has focused on defining the relationship between vitamin D status and infection and the antimicrobial peptide pathway with the overall clinical goal to improve host immunity in immunocompromised patients with respiratory infections.

• Han JE, Martin GS. Rational or rationalized choices in fluid resuscitation? Critical Care 2010;14:1006 • Han JE, Martin GS. Does albumin in fluid resuscitation save lives? Critical Care Medicine 2011;39:418-419 • Kempker JA, Han JE, Tangpricha V, Ziegler TR, Martin GS. Vitamin D and sepsis: An emerging relationship.Â

DermatoEndocrinology 2012;4:101-108

• Han JE, Trammell AR, Finklea JD, Udoji TN, Dressler DD, Honig EG, Abraham P, Ander DS, Cotsonis GA, Martin GS, Schulman DA. Evaluating Simulation-Based ACLS Education on Patient Outcomes: A Randomized, Controlled Pilot Study. J Grad Med Educ. 2014 Sep;6(3):501-6

• Han JE, Ziegler TR. Vitamin D supplementation in sepsis and critical illness: where are we now? Am J Respir Crit Care Med. 2014 Sep 1;190(5):483-5

C. Michael Hart, MD Associate Chief of Staff for Research Atlanta VA Medical Center Professor and Assistant Dean for VA Research Emory School of Medicine

Mike Hart, MD, a native of Birmingham, AL, received a BS degree from Duke University, MD from the University of Alabama at Birmingham, and residency training in Internal Medicine and fellowship training in Pulmonary and Critical Care Medicine at the University of Florida. Dr. Hart served as a faculty member in the Division of Pulmonary and Critical Care Medicine at Indiana University in Indianapolis for ten years before moving to his current institution, Emory University, in 2000. He has served in a variety of leadership roles at these institutions including Pulmonary and Critical Care Medicine Fellowship Program Director and as Pulmonary Section Chief at the Atlanta VA for nine years. His laboratory which focuses on vascular biology has been funded by the NIH and VA for over twenty years. Current areas of investigative focus include studies examining the ability of the nuclear hormone receptor, peroxisome proliferator-activated receptor gamma, to serve as a therapeutic target that regulates vascular dysfunction. The major focus of these studies is to better define basic mechanisms of disease in order to enable the development of more effective therapeutics.

Trainees in the Hart lab (since 2006)- NEXT PAGE

TRAINEE LEVEL YEARS DEGREE PROJECT

John Polikandriotis

Post- doctoral

4/04 - 3/06

PhD, Ohio State, 2004 Chronic alcohol ingestion alters reactive species production in lung

Rachel Nisbet Post- doctoral

7/06 - 7/08

MD, Emory University, 2003

PPAR gamma in pulm HTN

Carmello Blanquicett

Post- doctoral

8/06 - 12/09

PhD, Univ. Alabama Birmingham, 2005

Mechanisms of ethanol-induced lung dysfunction

Matt Wagner Post- doctoral

8/07 - 3/10

PhD. Georgia Tech, 2006 Mechanisms of ethanol-induced lung dysfunction

Alex Gluzman Post- doctoral

8/07 - 6/09

MD, Medical College Georgia, 2003

Role of PPAR gamma in pulm HTN

Helen Ward Post- doctoral

8/07 - 6/09

MD, Medical College of Virginia, 1999

Role of PPAR gamma in pulm HTN

Clintoria Richards

Post- doctoral

01/09 - 06/11

PhD, Univ. Alabama Birmingham, 2008

PPARg regulates reactive species in diabetes

Samantha Yeligar

Post- doctoral

8/09 - present

PhD, University Southern California, 2009

NADPH oxidase in alcohol-induced alveolar macrophage dysfunction

Bum-Yong Kang Post- doctoral

2009 - present

PhD, Seoul National University, 2002

The role of miRNA in pulmonary vascular dysfunction

Cherry Wongtrakool

Post- doctoral

2009 - present

MD, Cornell University, 1997

Mechanisms of nicotine induced lung disease

David Green Post- doctoral

1/10 - present

MD, Univ. Alabama at Birmingham, 2005

Mechanisms of hypoxic induction of Nox4 in pulmonary hypertension

Sherry Adesina Pre-doctoral

9/10 - 7/15

BS, University of Georgia, 2006

Effects of Trx 1 and Trx 2 Antioxidant Pools on Pulmonary Hypertension

Kaiser Bijli Post-doctoral

9/12 - present

PhD, University of Delhi, 2002

The role of Pyk2 in pulmonary vascular dysfunction

Justine I. Blum Pre-doctoral

6/14 - 11/14

BS, Dartmouth College, 2011

Regulation of HIF1a by PPARg

Kristal Carthan Post-doctoral

1/13 - 12/14

MD, Loyola University, 2008

Mechanisms of right ventricular hypertrophy

Abubakr Chaudhry

Post-doctoral

2015-20 MD, Allama Iqbal Medical College, Pakistan, 2009

Regulation of hypertrophic transcriptional pathways in the right ventricle

Esha Oommen Post-doctoral

2017-2018

MD, Temple University, 2012

Mitochondrial dysregulation in pulmonary hypertension

Aaron Trammell Post-doctoral

2016 - present

MD, Univ North Carolina, 2008

Metabolic dysfunction and pulmonary hypertension

Victor Tseng Post-doctoral

2018 - present

MD. Univ Wisconsin, 2012 Hyaluronan in PH metabolism and pathogenesis

Potential projects in the Hart lab generally focus on in vitro and in vivo pre-clinical models of disease. The specific focus of these projects varies depending on the ongoing collaborations in the lab and on the interests of the trainee. Most recent projects have focused on various aspects of pulmonary hypertension, including epidemiology. Current efforts are being directed to supplement projects in pre-clinical models with clinical data and specimens.

Recent publications (trainee names in italics) •

o Lu X, Bijli KM, Ramirez A, Murphy TC, Kleinhenz J, and Hart CM. Hypoxia downregulates PPARg via an ERK 1/2 - NF-kB - Nox4-dependent mechanism in human pulmonary artery smooth muscle cells. Free Radical Biology Med 63:151-160, 2013 PMCID:PMC3729594.

o Kang B-Y, Park KK, Green DE, Searles CD, Sutliff RL, Hart CM. Hypoxia mediates mutual repression between miR-27a and PPARg in the pulmonary vasculature. PLOS ONE 8(11) e79503 1-10, 2013. PMCID:PMC3828382.

o Yeligar SM, Harris FL, Hart CM, Brown LAS. Glutathione attenuates ethanol-induced alveolar macrophage oxidative stress and dysfunction by down-regulating NADPH oxidases. AJPLung 306(5):L429-41, 2014. PMCID:PMC3949056.

o Porter KM, Kang B-Y, Adesina SE, Murphy TC, Hart CM, Sutliff RL. Chronic hypoxia promotes pulmonary artery endothelial cell proliferation through H2O2-induced 5-lipoxygenase PLOS ONE 9(6): e98532, 2014. PMCID: PMC4048210.

o Wongtrakool C, Grooms K, Bijli K, Crothers K, Fitzpatrick AM, and Hart CM. Nicotine stimulates nerve growth factor in lung fibroblasts through an NFkB-dependent mechanism PLOS ONE 9(10):e109602, 1-11, 2014. PMCID: PMC4190411.

o Bijli KM, Kleinhenz J, Murphy TC, Kang B-Y, Adesina SB, Sutliff RL, and Hart CM. PPARg depletion stimulates Nox4 expression and pulmonary artery smooth muscle cell proliferation. Free Radic Biol Med 80:111-120, 2015. PMCID: PMC3729594.

o Adesina SE, Kang B-Y, Bijli KM, Ma J, Chen J, Murphy T, Hart CM, and Sutliff RL. Targeting mitochondrial reactive oxygen species to modulate hypoxia-induced pulmonary hypertension. Free Radic Biol Med 87:36-47, 2015. PMCID:PMC4615392

o Green DE, Murphy TC, Kang BY, Searles CD, Hart CM. PPARg ligands attenuate hypoxia-induced proliferation in human pulmonary artery smooth muscle cells through modulation of miR-21. PLOS ONE 10(7):e0133391, 2015. PMCID: PMC4514882.

o Kleinhenz JM, Murphy TC, Pokutta-Paskaleva AP, Gleason RL, Lyle AN, Taylor WR, Blount MA, Yang Q, Sutliff RL, Hart CM. Smooth muscle-targeted PPARg overexpression disrupts vascular wall structure and function. PLOS ONE 10(10):e0139756, 2015. PMCID: PMC4599849.

o Yeligar SM, Mehta AJ, Harris FL, Brown LAS, and Hart CM. Peroxisome proliferator-activated receptor gamma regulates chronic alcohol-induced alveolar macrophage dysfunction. Am J Resp Cell Mol Biol 55(1): 35-46, 2016. PMCID:PMC4942203.

o Kang B-Y, Park KK, Kleinhenz,JM, Murphy TC, Green DE, Bijli KM, Yeligar SM, Carthan KA, Searles CD, Sutliff RL, Hart CM. PPARg Activation Reduces Hypoxia-induced Endothelin-1 Expression through Upregulation of miR-98. Am J Resp Cell Mol Biol 54(1):136-46, 2016. PMCID: PMC4742924.

o Bijli KM, Kang BY, Sutliff RL, Hart CM. Proline-rich tyrosine kinase 2 downregulates PPARg to promote hypoxia-induced pulmonary artery smooth muscle cell proliferation. Pulmonary Circulation 6(2):202-210, 2016. PMCID: PMC4869925.

o Bedi B, Yuan Z, Joo M, Zughaier SM, Goldberg JB, Arbiser JL, Hart CM and Sadikot RT. Enhanced clearance of Pseudomonas aeruginosa by PPARg. Infection and Immunity 23;84(7):1975-85, 2016. PMCID:PMC4936346.

o Blum JI *, Bijli KM *, Murphy TC, Kleinhenz JM, Hart CM (*co-first authors). Time-dependent PPARg modulation of HIF-1a signaling in hypoxic pulmonary artery smooth muscle cells. Am J Med Sci 352(1):71-9, 2016. PMCID: PMC5483378.

o Kang BY, Park K, Kleinhenz JM, Murphy TC, Samit G, Tan F, Sutliff RL, Ofori-Acquah SF, Archer D, Hart CM. Peroxisome proliferator-activated receptor gamma regulates the V-Ets avian erythroblastosis virus E26 oncogene homolog 1/microRNA-27a axis to reduce endothelin-1 and endothelial dysfunction in the sickle cell mouse lung. Am J Resp Cell Mol Biol 56(1):131-44, 2017. PMCID in process.

o Adesina SE*, Wade BE*, Bijli KM, Kang B-Y, Williams CR, Ma J, Go Y-M, Hart CM, Sutliff RL (*co-first authors). Hypoxia inhibits expression and function of mitochondrial thioredoxin 2 to promote pulmonary hypertension. Am J Physiol: Lung Cel Mol Physiol 1;312(5):L599-L608, 2017. PMCID: PMC5451594.

o Chaudhry A*, Carthan KA*, Kang BY, Calvert J, Sutliff RL, Hart CM (*co-first authors). PPARg attenuates hypoxia-induced hypertrophic transcriptional pathways in the heart. Pulmonary Circulation (in press).

o Kim S-J, Cheresh P, Jablonski RP, Morales-Nebreda L, Cheng Y, Hogan E, Yeldandi A, Chi M, Piseaux R, Ridge K, Hart CM, Chandel N, Budinger GRS, Kamp DW. Mitochondrial catalase overexpressed transgenic mice are protected against lung fibrosis in part via preventing alveolar epithelial cell mitochondrial DNA damage. Free Radic Biol Med (in press).

o Bedi B, Maurice NM, Ciavatta VT, Tyor WR, Lynn KS, Yuan Z, Molina SA, Joo M, Goldberg JB, Koval M, Hart CM and Sadikot RT. PPAR” agonists attenuate biofilm formation by Pseudomonas aeruginosa. FASEB J (in press).

o Green DE, Murphy TC, Kang BY, Bedi B, Yuan Z, Sadikot RT, Hart CM. Peroxisome proliferator-activated receptor gamma enhances human pulmonary artery smooth muscle cell apoptosis through microRNA-21 and programmed cell death 4. Am J Physiol: Lung 313(2):L371-L383, 2017. PMCID: PMC5582937.

o Yeligar SM, Kang BY, Bijli KM, Kleinhenz JM, Murphy TC, Torres G, San Martin A, Sutliff RL, Hart CM. PPARg regulates mitochondrial structure and function and human pulmonary artery smooth muscle cell proliferation. Am J Resp Cell Mol Biol 58(5):648-57, 2018. PMCID: in process.

o Wade BE, Zhao J, Ma J, Hart CM, Sutliff RL. Hypoxia-induced alterations in the lung ubiquitin proteasome system during pulmonary hyertension pathogenesis. Pulmonary Circulation 8(3): 1-17, 2018. PMCID: in process.

o Mwangi SM, Li G, Ye L, Reichardt F, Yeligar SM, Hart CM, Czaja MJ, and Srinivasan S. Glial cell line derived neurotrophic factor enhances autophagic flux and mitochondrial respiration in rat and mice hepatocytes. Hepatology (in press).

o Tseng V, Sutliff RL, Hart CM. The Redox Biology of Peroxisome Proliferator-Activated Receptor Gamma in Pulmonary Hypertension. Antioxidants & Redox Signaling (in press).

o Trammell AW, Shah AJ, Phillips LS, Hart CM. Mortality in U.S. veterans with pulmonary hypertension: a retrospective analysis of survival by subtype and baseline factors. Pulmonary Circulation 9:2045894019825763, 2019.

o Yeligar SM, Mehta AJ, Harris FL, Brown LAS, and Hart CM. Pioglitazone reverses alcohol-induced alveolar macrophage phagocytic dysfunction (submitted).

Andre Holder, MD, MSc Assistant Professor of Medicine Division of Pulmonary, Critical Care, Allergy and Sleep Medicine

Dr. Holder came to Emory in 2014 to begin his career as clinician scientist faculty. After finishing a combined emergency medicine and internal medicine residency in 2009, he completed a Masters of Science in Clinical Research Methodology

at Albert Einstein College of Medicine in New York. His research interest are prediction and management of sepsis progression.

During his clinical fellowship in critical care medicine, he did an NIH T32 research fellowship at the University of Pittsburgh. His focus at that time was broadened to hemodynamic monitoring and management of critical illness in general. He performed animal studies in their cardiopulmonary lab using dynamic complex physiologic features as markers for disease progression in a hemorrhage model.

Dr. Holder's current research at Emory focuses on understanding the progression of inflammatory diseases that cause critical illness, with a specific emphasis back on sepsis pathophysiology. Through collaborations with colleagues in the Department of Biomedical Informatics, he employs advanced data-driven techniques such as nonlinear modeling and machine learning approaches to predict the trajectory of complex syndromes like sepsis. His main research focus is proving whether temporal trends in physiologic and laboratory biomarkers, and complex measures of physiologic variability can predict sepsis-related organ dysfunction, cardiovascular collapse (shock), and death. Other research and clinical interests include cardiopulmonary resuscitation, and appropriate use of hemodynamic monitoring and cardiopulmonary interaction in critical illness.

Recent manuscripts:

• Shashikumar SP, Stanley MD, Sadiq I, Li Q, Holder A, Clifford GD, Nemati S. Early sepsis detection in critical care patients using multiscale blood pressure and heart rate dynamics. J Electrocardiol. 2017 Aug. [Epub ahead of print] PMID: 28916175.

• Holder AL, Overton E, Lyu P, Kempker JA, Nemati S, Razmi F, Martin GS, Buchman TG, Murphy DJ. Serial Daily Organ Failure Assessment Beyond ICU Day 5 Does Not Independently Add Precision to ICU Risk-of-Death Prediction. Crit Care Med. 2017 Sep. Epub ahead of print. PMID: 28906286.

• Holder AL, Gupta N, Lulaj E, Furgiuele M, Hidalgo I, Jones MP, Jolly T, Gennis P, Birnbaum A. Predictors of early progression to severe sepsis or shock among emergency department patients with nonsevere sepsis. Int J Emerg Med. 2016 Dec;9(1):10. PubMed PMID: 26908009.

Potential mentee projects

• Trended clinical and laboratory data to predict sepsis & septic shock • Risk stratification through modified simple clinical biomarkers • What is the best definition for sepsis?

William R. Hunt, MD Assistant Professor of Medicine Division of Pulmonary, Allergy, Critical Care & Sleep Medicine Director, Emory Adult Cystic Fibrosis Center Over the course of my combined internal medicine and pediatrics residency training I developed a particular interest

and experience in chronic childhood illnesses, especially cystic fibrosis (CF). I was mentored by Dr. Irena Petrache and explored the role of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) dysfunction in pulmonary endothelial cell barrier integrity. Following pursuit of fellowship research training in adult pulmonary and critical care medicine I continued to sharpen hypothesis-driven research design. I trained in the laboratory of Dr. Nael McCarty, director of Emory+Childrens” Center for Cystic Fibrosis and Airways Disease Research, under the direct mentorship of Dr. Nael McCarty and Dr. Jason Hansen. Our research focused on innate immunity within the CF lung environment in the setting of CF-related diabetes (CFRD). Specifically, our focus has been the development and characterization of a murine model of CFRD and exploring the mechanisms of CFRD”s impact on lung function (immune cell activity and redox signaling in particular). I continue to collaborate with researchers within Emory+Childrens” Center for Cystic Fibrosis and Airways Disease Research on mechanisms of CF lung dysfunction as well as clinical outcomes.

My clinical interests is with CF and lung transplantation. I am the current medical director for the adult CF program at Emory University. I also serve as the associate director for the CF@lanta Research and Development Program (RDP) Clinical and Translational Core. Additionally, I serve as a sitting member for the CF@lanta RDP and the CF@lanta CF Scholars steering committees. My research interests include assessing objective measures of transition readiness in CF, experimental model systems for CF, CFRD lung disease and CF-specific lung transplant outcomes.

Recent Research Projects with Trainees

• Christopher Reed, Brigham Young University -CFTR Extracellular Redox Regulation • Brandi Middour-Oxler, Augusta State- Assessing Objective Measurements of Transition Readiness in Cystic Fibrosis • Leah Cohen, Emory University- Assessment of FEV1 Variability in Cystic Fibrosis Management • Ellie Kaplan, Emory University- Assessment of Patient and Care Giver Cystic Fibrosis Specific Genetic Knowledge • Laina Lusk, Emory University- Assessment of Educational Intervention for Cystic Fibrosis Specific Genetic Knowledge Retention • Tina Kushary, Emory University - Assessment Cystic Fibrosis Specific Genetic Knowledge and Family Planning Perceptions • Haider Ali, Emory University - Assessment of Cystic Fibrosis Bone Mineral Density Pre-Lung Transplant with Post-Lung Transplant

Outcomes • Jonny Salud - Assessment of Geographic Location and Social Predictors for Cystic Fibrosis Clinic Utilization • Dhurv Patel- Assessment of Pre-Transplant Diagnosis on Post-Transplant Lung Pathology

Recent Abstracts and Manuscripts with Trainees

1. Cohen, Leah, Guarner, J., Hunt, William R. A novel presentation of Mycobacterium avium complex in a recipient of a lung transplant: a case report. J Med Case Rep. 2017 Aug 28;11(1):240.

2. Hunt, William R., Guentert, D.E., Brown, L.S., Stecenko, A. Prediabetes and redox imbalance in young children with CF. Pediatr Pulmonol 2016; Supplement 45:445A

3. Middour-Oxler, B.J., Bergman, S., Blair, S.D., Pendley, S., Crews, B., Siragusa, A., Walker, S.D., Stecenko, A., Hunt, W.R. A retrospective survey of patient experience with pediatric to adult transition of CF care. Pediatr Pulmonol 2016; Supplement 45:477-478A

4. Ali, H., Ajani, S., Cohen, L.A., Neujahr, D., Hurtik, M., Hunt, W.R. The effect of bone mineral density on lung transplantation outcomes in adults with cystic fibrosis. Pediatr Pulmonol 2017; Supplement 47:468-469A

5. Linnemann, R.W., Wei, J., Blair, S.D., Hunt, W.R., Walker, S.D., Stecenko, A. Mental health and pulmonary outcomes in CF adolescents and adults. Pediatr Pulmonol 2017; Supplement 47:494A

6. Middour-Oxler, B., Blair, S.D., Pendley, S., Crews, B.M., Stecenko, A., Hunt, W.R. Past, present, and future directions of a multi-site transition program for adolescents with cystic fibrosis. Pediatr Pulmonol 2017; Supplement 47:507A

7. Middour-Oxler, B., Blair, S.D., Pendley, S., Crews, B.M., Walker, S.D., Stecenko, A., Hunt, W.R. Prospective assessment of transition anxiety and self-perceived readiness in a large CF center. Pediatr Pulmonol 2017; Supplement 47:508A

8. Hunt, W.R., Bergman, S., Middour-Oxler, B. Participation in a formalized CF transition programis associated with decreased pulmonary exacerbations. Pediatr Pulmonol 2017; Supplement 47:508A

Michael F. Iademarco, MD, MPH Captain, U.S. Public Health Service Adjunct Assistant Professor of Medicine Director, Center for Surveillance, Epidemiology, and Laboratory Services, CDC

I came to CDC and Emory in 1998 as a medical-epidemiologist and pulmonologist. Since then, I have served in four positions in CDC's Division of Tuberculosis Elimination, as HHS's Health Attach in Hanoi, and throughout as staff physician at the Atlanta VA Medical Center, attending in the MICU. In 2014, I came to lead CDC's Center for Surveillance, Epidemiology, and Laboratory Services, home of iconic scientific services such as MMWR, Vital Signs, The Guide to Community Preventive Services, WONDER, Epi Info, National Notifiable Disease Surveillance System, the National Syndromic Surveillance Program, Office of Public Health Genomics, and Epidemic Intelligence Service. I also hold a joint appointment in the Rollins School of Public Health.

My area of scholarly interest is in tuberculosis, surveillance, diagnostic tests, and public health policy. Trainees who wish to work with me must have an Emory Pulmonary faculty co-mentor; should have an interest in surveillance, epidemiology, laboratory systems, workforce, or public health information dissemination; and be willing to work on research teams. Prior experience in data science and analytic statistical programming would be useful. Alternatively, I am available to a trainee/faculty pair as a consultant.

• CSELS information • Publications on Google Scholar

Imran Iftikhar, MD Associate Professor of Medicine, Department of Medicine Section Chief - Pulmonary, Allergy, Critical Care and Sleep Medicine - Emory Saint Joseph's Hospital I started my Emory career in May 2016. I am primarily based at Emory Saint Joseph”s hospital but also have clinics at the Emory Sleep Center (12 EP). The primary focus of my research and scholarly activities has been related to the health

outcomes of sleep disordered breathing. I specialize in the statistical techniques of meta-analysis, from the simple direct pair-wise meta-analysis to the most complicated network comparative meta-analyses utilizing both Bayesian and Frequentist methodologies. In my brief academic tenure, I have always welcomed and encouraged residents and fellows in learning the statistics of pairwise and network comparative meta-analysis.

Published and Accepted Research Articles (clinical, basic science, other) in Refereed Journals (trainees names in italics):

1. Iftikhar I, Abdelmannan D, Daw HA. Dermatomyositis and esophageal cancer. South Med J. 2006 Jul;99 (7):777-9. 2. Iftikhar I, Ahmed M, Tarr S, Zyzanski SJ, Blankfield RP. Comparison of obstructive sleep apnea patients with and without leg

edema. Sleep Med. 2008 Dec;9(8):890-3. 3. Blankfield RP, Iftikhar I, Glickman E, Harris S. Temperature and blood pressure following amlodipine overdose. Wilderness

Environ Med. 2008 Spring;19(1):39-41.

4. Iftikhar IH, Blankfield RP. Effect of Continuous Positive Airway Pressure on Hemoglobin A1c in Patients with Obstructive Sleep Apnea: A Systematic Review and Meta-analysis. Lung. 2012 Dec;190(6):605.

5. Iftikhar I, Tisch D, Hassan, N, Blankfield RP. Meta-Analysis of the Hemodynamic Properties of Antihypertensive Medications. ISRN Hypertension. Volume 2013 (2013) 1-10.

6. Iftikhar I, Hays E, Iverson MA, Magalang UJ, Maas AK. Effect of oral appliances on blood pressure in patients with obstructive sleep apnea: A systematic review and meta-analysis. Journal of Clinical Sleep Medicine. 2013 Feb 1;9(2):165-74.

7. Iftikhar I, Khan M, Das A, Magalang UJ. Meta-analysis: Continuous Positive Airway Pressure Therapy Improves Insulin Resistance in Patients with Obstructive Sleep Apnea. Ann Am Thorac Soc. 2013 Apr; 10(2):115-20.

8. Iftikhar IH. Effects of dietary weight loss on obstructive sleep apnea. Sleep Breath. 2014 Mar;18(1):3. 9. Iftikhar IH, Kline CE, Youngstedt SD. Effects of exercise training on sleep apnea: A meta-analysis. Lung. 2014 Feb;192(1):175-

84. 10. Iftikhar IH, Imtiaz M, Brett, AS, Amrol DA. Cardiovascular safety of long acting beta agonist-inhaled corticosteroid combination

products in adult patients with asthma: a systematic review. Lung. 2014 Feb;192(1):47-54. 11. Iftikhar IH, McGuire FR, Musani AI. Efficacy of bronchoscopic lung volume reduction: A meta-analysis. Int J Chron Obstruct

Pulmon Dis. 2014 May 14;9:481-91. 12. Iftikhar IH, McGuire FR, Musani AI. Predictors of efficacy for endobronchial valves in bronchoscopic lung volume reduction: A

meta-analysis. Chron Respir Dis. 2014 Nov;11(4):237-45. 13. Teferra RA, Grant JB, Mindel J, Siddiqi TA, Iftikhar IH, et al. Cost Minimization Using An Artificial Neural Network Sleep Apnea.

Annals ATS. 2014 Sep;11(7):1064-7. 14. Iftikhar IH, Valentine CW, Bittencourt L, Cohen DL, Fedson AC, Gíslason T, Penzel T, Phillips CL, Yu-Sheng L, Pack AI, Magalang

UJ et al with the SAGIC Investigators. Effects of Continuous Positive Airway Pressure on Blood Pressure in Patients with Resistant Hypertension and Obstructive Sleep Apnea: A meta-analysis. J Hypertension. 2014 Dec;32(12):2341-50.

15. Blankfield RP, Iftikhar IH (Senior/corresponding author). FDA regulation of drugs that raise Blood Pressure. J Cardiovasc Pharmacol Ther. 2015 Jan;20(1):5-8.

16. Iftikhar IH, Donley MA, Owens W. Prone Positioning in ARDS. Critical Care Medicine. October 2014.Feb;43(2):e55-6. 17. Iftikhar IH, Hoyos CM, Phillips CL, Magalang, UJ. Meta-analyses of the Association of Sleep Apnea with Insulin Resistance, and

the Effects of CPAP on HOMA-IR, Adiponectin, and Visceral Adipose Fat. J Clin Sleep Med. 2015 Apr 15;11(4):475-85. 18. Iftikhar IH, Donley M, Al-Jaghbeer M, Monseratte A. CPAP plus Weight Loss for OSA, Association of Cancer with OSA, and

Hypoglossal Nerve Stimulation for OSA Treatment. Am J Respir Crit Care Med. 2015 Apr 1;191(7):845-7. 19. Iftikhar IH, Musani AI. Narrow-band imaging bronchoscopy in the detection of premalignant airway lesions: a meta-analysis of

diagnostic test accuracy. Ther Adv Respir Dis. 2015 Jun 17. 20. Iftikhar IH, Donley MA, Mindel J, Pleister A, Soriano S, Magalang UJ. Sleep Duration and Metabolic Syndrome: An Updated

Dose-Risk Meta-analysis. Ann Am Thorac Soc. 2015 Sep;12(9):1364-72. 21. Iftikhar IH, Albisher E, Vaishnavi C, Paul G. Physical activity and insomnia, short sleep and insulin resistance, and effect of poor

sleep on child”s academic performance. Recommended Reading from the Ohio State University Sleep Medicine Fellowship Program. American Journal of Respiratory & Critical Care Medicine. 2016 Feb 3. EPUB. Ahead of print.

22. Al-Jaghbeer M, Marcus M, Durkin M, McGuire FR, Iftikhar IH. Diagnostic yield of Electromagnetic Navigational Bronchoscopy. Therapeutic Advances in Respiratory Medicine journal. March 4. 2016. EPUB. Ahead of print.

23. Iftikhar IH. Incretins and Insulin Resistance in Obstructive Sleep Apnea: Chicken or the Egg. Annals of the American Thoracic Society. Accepted. May 10th, 2016.

24. Iftikhar IH. MADs and Positional Sleep Apnea: More than Meets the Eye! Journal of Clinical Sleep Medicine. 2016 Aug 15;12(8):1079-80.

25. Imran H. Iftikhar, Lia Bittencourt, Shawn D. Youngstedt, Najib Ayas, Peter Cistulli, Richard Schwab, Martin W. Durkin, Ulysses J. Magalang. Comparative efficacy of CPAP, MADs, exercise-training and dietary weight loss for sleep apnea: a network meta-analysis. Published (in Press/ePUB Ahead of Print) SLEEP MEDICINE (Official Journal of the World Association of Sleep Medicine and International Pediatric Sleep Association) “ http://dx.doi.org/10.1016/j.sleep.2016.06.001

Book Chapters:

i. Iftikhar I, Khan, M. Plasma Levels of MCP-1 and Adiponectin in Obstructive sleep apnea. Best of Sleep Medicine 2011. (published)

ii. Chapter: Obesity Hypoventilation Syndrome

Volume: Respiratory Manifestations of Neuromuscular and Chest Wall Diseases 2017 (Guest Editor: Dennis F McCool, MD)

Book: CLINICS IN CHEST MEDICINE

Work in progress

Authors: Imran Iftikhar (Emory), Lana Algothani (Ohio State)

iii. Chapter: Hypertension in Obstructive Sleep Apnea

Book: Hypertension: A Case-based Approach by Donald DiPette

Work in progress

Authors: Imran Iftikhar (Emory), Catherine Millender (USC)

Abstract Presentations at National/International, Regional, and Institutional Conferences:

[* presented; mentees names in italics]

International:

1) *Iftikhar IH, Shatnawei A, Shaikh A. Normal Angiogram MI. Endovascular Summit 2006. Jackson Hole, Wyoming. August 2-4, 2006. [oral presentation]

2) AbdelMannan D, Ahmed M, Woyshville M, Ricaurte B, Iftikhar I. The Incidence of the Metabolic Syndrome as a Function of Severity in Obstructive Sleep Apnea. Poster Presentation. Endocrine Society 88th Annual Meeting, Boston, MA. June 24-27, 2006. [poster presentation]

3) *Iftikhar IH. Body Mass Index and the incidence of hypertension in obstructive sleep apnea patients. American College of Chest Physicians Annual Meeting. Salt Lake City UT. September 2006. [poster presentation]

4) *Iftikhar I, Ahmed M, Tarr S, Zyzanski S, Blankfield RP. Comparison of Obstructive Sleep Apnea Patients with and without Leg Edema. American College of Chest Physicians Annual Scientific Meeting, Salt Lake city, Utah. 2006. [poster presentation]

5) *Iftikhar I, Harris NS, Blankfield RP. Temperature and Blood Pressure Following Amlodipine Overdose: A Test of the Thermoregulatory-Vascular Remodeling Hypothesis. Poster presentation at the Arteriosclerosis, Thrombosis, and Vascular Biology Annual Conference. Chicago, IL. April 19-21, 2007. [poster presentation]

6) *Iftikhar I, Ahmed M, Blankfield RP. Nocturnal Oxygen Desaturation and the prevalence of Metabolic Syndrome. Poster presentation at the Arteriosclerosis, Thrombosis, and Vascular Biology Annual Conference, Chicago, IL. April 19-21, 2007. [poster presentation]

7) *Iftikhar I, Tisch D, Blankfield RP. Meta-analysis: Evaluation of hemodynamic variables of antihypertensive drugs facilitates in choosing optimal antihypertensive therapy. American Society of Hypertension meeting, San Francisco. May 06, 2009. [poster presentation]

8) *Iftikhar I. Meta-analysis: Effect of CPAP on Insulin resistance. American Thoracic Society, San Francisco, May, 2012. [poster presentation]

9) Teferra RA, Afaq T, Iftikhar I, et al. Likelihood ratios for clinical predictions of Obstructive sleep apneausing AASM polysomnography scoring rules. American Thoracic Society, San Francisco, May, 2012. [poster presentation]

10) *Iftikhar, IH, Kline CE, Youngstedt, SD. Effects of Exercise Training and Non-Surgical Weight Loss on Obstructive Sleep Apnea: A meta-analysis. Annual SLEEP meeting, Baltimore, MD, June 2013. [poster presentation]

11) Mindel, JW, Ajaz, F, Teferra R, Afaq, T, Iftikhar, IH et al. OSUNET: An Artificial Neural Network Sleep Apnea Prediction Tool for In-home and In-lab Polysomnography. Annual SLEEP meeting, Baltimore, MD, June 2013. [poster presentation]

12) Stroman AL, Iftikhar IH. Vanishing Lung Syndrome: A Rare Chest X-Ray. American Thoracic Society International Conference, San Diego, CA, 2014 May 16. [poster presentation]

13) *Iftikhar, IH. Efficacy Of Bronchoscopic Lung Volume Reduction: A Meta-analysis. American Thoracic Society Meeting, San Diego CA, May, 2014. [oral presentation]

14) *Iftikhar, IH, C. Valentine, L.R.A. Bittencourt, D. Cohen, A.C. Fedson, T. Gislason, T. Penzel, C.L. Phillips, L. Yu-sheng, A.I. Pack, U.J. Magalang; for the SLEEP APNEA GENETICS INTERNATIONAL CONSORTIUM. Effects of Continuous Positive Airway Pressure on Blood Pressure in Patients with Resistant Hypertension and Obstructive Sleep Apnea: A meta-analysis. American Thoracic Society Meeting, San Diego CA, May, 2014. [poster presentation]

15) Xiao A, Iftikhar IH, Durkin M, Srinivasan S. Effects of Acupuncture treatment on cognitive function in patients with vascular dementia: A meta-analysis. American Association of Geriatric Physicians, New Orleans LA, March 2015 Meeting. [poster presentation]

16) *Iftikhar IH, Donley MA, Musani AI. Diagnostic accuracy of Narrow-band imaging and Autofluorescence bronchoscopy. European Association of Bronchology and Interventional Pulmonology, Barcelona Spain April 2015. [oral presentation]

17) *Iftikhar IH, Donley, MA, Magalang, UJ. Sleep Duration and Metabolic Syndrome: A Dose-Risk Meta-analysis. American Thoracic Society, Denver CO, May 2015 Conference. [poster presentation]

18) *Iftikhar IH, Donley, MA, Magalang, UJ. Sleep Duration and Insulin Resistance: A Meta-analysis. Annual SLEEP meeting, Seattle WA, June 2015. [poster presentation]

19) Al-Jaghbeer M, McGuire F, Iftikhar IH (senior author). Diagnostic Yield and Safety of Electromagnetic Navigational Bronchoscopy: A Single Center Experience. American Thoracic Society. San Francisco. Monday, May 16, 2016. [poster presentation]

20) *Iftikhar IH, Bittencourt L, Youngstedt SD, Ayas N, Cistulli P, Schwab R, Durkin M, Magalang U. Comparative Efficacy of Continuous Positive Airway Pressure, Mandibular Advancement Devices, Dietary Weight Loss and Exercise Training in the Treatment of Obstructive Sleep Apnea: A Network Meta-Analysis. American Thoracic Society. San Francisco. Monday, May 15, 2016. [oral presentation]

21) *Iftikhar IH, Essa Albisher, Challapalli Sri, Grace P. Sleep Duration And Cancer Risk: An Updated Meta-analysis Of Prospective Studies. American Academy of Sleep Medicine, Denver CO, Jun 13, 2016. [poster presentation]

Regional:

22) *Iftikhar I. Obstructive Sleep Apnea and Hypertension, “The Dose Effect Relationship”. 2006 ACP Ohio Chapter Scientific Meeting, Columbus, OH October 19-20, 2006. [poster presentation]

23) *Iftikhar I, Ahmed M, ZyzanskiS, Tarr S, Blankfield RP. Obstructive Sleep Apena and Leg Edema: A retrospective study. American College of Physicians Ohio Chapter Conference, Columbus OH. October 11 “12, 2007. [poster presentation]

24) Stroman AL, Iftikhar IH. Vanishing Lung Syndrome: A Rare Chest X-Ray. American Lung Association of the Midlands Annual Meeting; 2013 November 6; Columbia, SC. [oral presentation]

25) Breneman C, Porter R, Iftikhar IH, Smith S, Wang X. The Relationship between Aerobic Fitness and Physical Activity with Sleep Characteristics in Sedentary Older Women. American College of Sports Medicine South east Regional Chapter, Greenville SC. 2014. [poster presentation]

26) Moizuddin, Iftikhar IH. Quality Improvement: Practice Management Gaps in Chronic Obstructive Pulmonary Disease: A Retrospective Chart Review. South Carolina Medical Association meeting, Charleston, SC June 2015. [poster presentation]

Institutional:

27) AbdelMannan D, Ahmed M, Woyshville M, Ricaurte B, Iftikhar I. The Incidence of the Metabolic Syndrome as a Function of Severity in Obstructive Sleep Apnea. Annual Research Day competition at Fairview Hospital, Cleveland Clinic June 2006. [oral presentation]

28) *Iftikhar I, Tisch D, Blankfield RP. Meta-analysis: Evaluation of hemodynamic variables of antihypertensive drugs facilitates in choosing optimal antihypertensive therapy. Annual Research Day competition at Fairview Hospital, Cleveland Clinic 2008. First position in competition. [oral presentation]

29) *Iftikhar I, Hays E, Iverson MA, Magalang UJ, Maas AK. Effect of oral appliances on blood pressure in patients with obstructive sleep apnea: A systematic review and meta-analysis. Annual VA research Day at WJB Dorn VA Medical Center. 4/15/2012. [poster presentation]

30) Moizuddin M, Iftikhar IH. Quality Improvement: Practice Management Gaps in Chronic Obstructive Pulmonary Disease: A Retrospective Chart Review. Annual Palmetto Health Richland GME Research Day April 2015. [poster presentation]

31) Shaukat M, Iftikhar IH. Quality Improvement:An Asthma Quality Improvement Project: Improving Care in Ambulatory Setting. Annual Palmetto Health Richland GME Research Day April 2015. [poster presentation]

32) Al-Jaghbeer M, Iftikhar IH. Factors Influencing Outcome in Electromagnetic Navigational Bronchoscopy. Annual Palmetto Health Richland GME Research Day April 2015. [poster presentation]

Mentees and their current positions:

PhD Students Directly Supervised:

Time in Bed Extension in Older Adults: Impact on Cognition, Inflammation, and Mood. This study was applied for NIH F31 Training Grant for Alexandria Reynolds (Ph.D student), University of SC, School of Public Health. 2014-2015

Role: Thesis Mentor.

Current position: Assistant Professor at University Virginia-Wise.

Residency Program:

1. Erin Hays, MD. Research mentor (2011-2012). Current position: Pulmonary Medicine attending physician at Self Regional HealthCare- Greenwood SC

2. Michelle Iverson, MD. Research mentor (2011-2012). Current position: Pulmonary Medicine attending physician at Carolina Pines Medical Center, SC

3. Jake Krieg, MD. Research mentor (2011-2012). Current position: Assistant Professor, Pulmonary Medicine, University of South Carolina, Columbia SC

4. Mohammad Imtiaz, MD. Research mentor (2012-2013). Current position: Assistant Professor, Pulmonary Medicine, Albany Medical College, Albany, NY

5. Christina Christ, MD. Research mentor (2013-2014). Current position: 3rd year PCCM Fellow at University of Louisiana-New Orleans.

6. Mohammad Moizuddin, MD. Research mentor (2013-2015). Current position: Pulmonary Medicine attending physician, Thibodaux Regional Medical Center, LA.

7. Alexis Stroman, MD. Research mentor (2013-2015). Current position: Pulmonary Medicine attending physician, Dorn VA Medical Center, Columbia SC

8. Meredith Donley, MD. Research mentor (2013-2015). Current position: 2nd year fellow, Pulmonary Medicine, University of South Carolina/Palmetto Health Richland, Columbia SC

9. Angel Monseratte, MD. Research mentor (2014-2015). Current position: 2nd year fellow, Pulmonary Medicine, University of South Carolina/Palmetto Health Richland, Columbia SC

10. Mohammad Al-Jaghbeer, MD. Research mentor (2014-2015). Current position: 2nd year fellow, Pulmonary Medicine, University of South Carolina/Palmetto Health Richland, Columbia SC

11. Adam Pleister, MD. Research mentor (2014-2015). Current position: Assistant Professor, Joint appointment in the Divisions of Cardiology and Pulmonary, Critical Care & Sleep Medicine, The Ohio State University.

Dean P. Jones, PhD Professor of Medicine Director, Clinical Biomarkers Laboratory Dean Jones is a Professor in the Department of Medicine (Pulmonary Division) with secondary appointments in Biochemistry and Pediatrics at Emory University, Atlanta, GA. He received a PhD in Medical Biochemistry from Oregon

Health Sciences Univ., Portland, in 1976. He studied nutritional biochemistry at Cornell University and molecular toxicology at the Karolinska Institute as a post-doctoral fellow. He joined Emory University as an Assistant Professor of Biochemistry in 1979, was subsequently promoted to Associate Professor in 1985 and Professor of Biochemistry in 1990. He became Professor of Medicine and Director of the Clinical Biomarkers Laboratory in 2003. He is the Integrated Health Sciences Facility Core Director of the NIEHS-supported HERCULES Exposome Research Center and directs metabolomics cores for NIH-funded programs in Children’s Health Exposure Analysis Resource, Red Blood Cell Stability for Transfusion and the Malaria Host-Pathogen Interaction Center. His research career has included studies of mitochondrial mechanisms of toxicity, redox systems biology, oxidative stress and antioxidant systems, compartmentation of metabolism and high-resolution metabolomics. He currently is focused on applications of ultra-high resolution mass spectrometry for precision medicine, with a long-term goal to use this as a foundation to sequence the exposome. These methods allow measurement of thousands of low abundance metabolites, including those derived from the innate metabolism, environment, diet, drugs and microbiome. He has recently focused on low-level environmental exposures, such as dietary cadmium, which can impact onset and progression of chronic diseases, and has active NIH-supported research programs on the metabolomics of cardiovascular, lung, eye, neurodegenerative and infectious diseases and aging. He has extensive collaborations to study diverse populations and disease processes.

Recent trainees he mentored

• Douglas Walker, PhD candidate studying use of high-resolution metabolomics for biomonitoring environmental exposures and linking exposures to health outcomes

• Ken Liu, PhD candidate studying pharmacometabolomics of adverse drug reactions • Joshua Chandler, PhD, Post-doctoral fellow studying integrated omics of inflammation-derived oxidants in lung cells and in vivo • Jolyn Fernandez, PhD, Post-doctoral fellow studying mitochondrial oxidative stress induced by manganese and developing

integrated models of redox proteomics, metabolomics and transcriptomics • Xin Hu, PhD, Post-doctoral fellow studying integrated omics of low-dose environmental cadmium toxicity specifically related to

pro inflammatory and profibrotic signaling in the lung

Potential Projects Many laboratory projects are possible, but a better training structure would probably involve collaboration with Young-Mi Go, PhD, Shuzhao Li, PhD, and/or a clinical scientist using our “omics analytical capabilities to address highly relevant clinical questions. This can be done for almost any of the relevant clinical aspects of the Division, I.e., Pulmonary, Allergy, Critical Care and Sleep Medicine. The main limitation is that the time frame to initiate and complete a clinical protocol usually makes it impractical to do this in its entirety as a Fellow. Hence, we would want to take advantage of ongoing studies, sample repositories and existing data. Given the history of research in the Division and the existing collaborations and interactions with clinical scientists at other institutions, this mostly requires initiative to develop a workable plan.

Publications A complete list of my published work: http://www.ncbi.nlm.nih.gov/myncbi/browse/collection/40814271/?sort=date&direction=descending

Or, go to "Google Scholar", enter "Dean P Jones Emory Lung" for papers more relevant to pulmonary research

Bum-Yong Kang, PhD Assistant Professor of Medicine

I joined Emory University in 2009. I have intensively investigated novel approach microRNA analysis in pathogenesis of pulmonary hypertension (PH), leading not only to successful intra-institutional collaboration but also to research funding to elucidate the role of microRNA of human diseases. I received my Ph.D. in molecular

population genetics from Seoul National University, South Korea and was a Postdoctoral Fellows in the Department of Biology at Dalhousie University, Canada (2004-2005) and in the Department of Medicine at University of Arkansas for Medical Sciences (2006-2009). Currently, my research career focuses on the examination of the mechanisms of PH with sickle cell disease (SCD). Most recently, I have extended my novel work on pulmonary vascular biology and endothelial-to-mesenchymal transition (EndoMT) using miRNAs and long non-coding RNAs (lncRNAs) to the field of hypoxia-induced PH and SCD with PH. My long-term research goal is to create my own model in the pathogenesis of SCD-PH; how does pulmonary vascular remodeling generate in the pulmonary vasculature? To elucidate this question, this model will use integrated–OMICS data: functional genomics, proteomics, microRNAs, long non-coding RNAs, and metabolomics analysis, lead not only to identifying innovative approaches to the treatment of pulmonary vascular disease, but also to clarifying mechanisms by which PPARγ can favorably modulate the expression of proliferative mediators in SCD-PH. Other recent manuscripts:

• Yeligar SM*, Kang BY*, Bijli KM*, Kleinhenz1 JM, Murphy TC, Torres G, San Martin A, Sutliff RL, and Hart CM. PPARγ regulates mitochondrial structure and function and HPASMC proliferation. American Journal of Respiratory Cell and Molecular Biology. 2018; 58(5):648-657. PMID: 29182484. *Co-First Authors.

• Kang BY*, Park KK, Kleinhenz JM, Murphy TC, Sutliff RL, Archer D., and Hart CM. PPARγ Regulates the ETS1/miR-27a Axis to Reduce ET-1 and Endothelial Dysfunction in the Sickle Cell Mouse Lung. American Journal of Respiratory Cell and Molecular Biology. 2017; 56(1):131-144, 2017. PMID: 27612006. * Corresponding Author

• Green DE, Murphy TC, Kang BY, Bedi B, Yuan Z, Sadikot RT, Hart CM. Peroxisome Proliferator-Activated Receptor Gamma Enhances Human Pulmonary Artery Smooth Muscle Cell Apoptosis Through MicroRNA-21 and Programmed Cell Death 4. Am J Physiol Lung Cell Mol Physiol. 2017; 313(2): L371-L383. PMID: 28522568.

• Chaudhry A, Carthan KA, Kang BY, Calvert J, Sutliff RL, Michael Hart C. PPARγ attenuates hypoxia-induced hypertrophic transcriptional pathways in the heart. Pulm Circ. 2017 Mar 13;7(1):98-107. PMID: 28680569.

• Adesina SE, Wade BE, Bijli KM, Kang BY, Williams CR, Ma J, Go YM, Hart CM, Sutliff RL. Hypoxia inhibits expression and function of mitochondrial thioredoxin 2 to promote pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2017;312(5):L599-L608. PMID: 28130258.

• Kang BY*, Park KK, Kleinhenz JM, Murphy TC, Green DE, Bijli KM, Bijli KM, Yeligar SM, Carthan KA, Searles CD, Sutliff RL, and Hart CM. PPARγ activation reduces hypoxia-induced endothelin-1 expression through upregulation of miR-98. American Journal of Respiratory Cell and Molecular Biology. 54(1):136-46, 2016. PMCID: PMC4742924. * Corresponding Author

• Bijli KM, Kang BY, Sutliff RL, Hart CM. Proline-rich tyrosine kinase 2 downregulates peroxisome proliferator-activated receptor gamma to promote hypoxia-induced pulmonary artery smooth muscle cell proliferation. Pulm Circ. 2016;6(2):202-10. PMID: 27252847.

• Green DE, Murphy TC, Kang BY, Searles CD, and Hart CM. PPARγ ligands attenuate hypoxia-induced proliferation in human pulmonary artery smooth muscle cells through modulation of miR-21. PLoS ONE 2015; 10: e0133391. PMCID: PMC4514882.

• Kang BY, Park KK, Green DE, Bijli KM, Searles CD, Sutliff RL, and Hart CM. Hypoxia mediates mutual repression between microRNA-27a and PPARγ in the pulmonary vasculature. PLoS ONE 2013; 8(11):e79503. PMCID: PMC3828382.

Jordan A. Kempker, MD, MSc Assistant Professor of Medicine In 2015 I joined Emory faculty after completing my residency and fellowship training here. During my fellowship training I completed a Masters of Science and Clinical Research through Emory Rollins School of Public Health and my research interests are in intersections of health services research and data science in the topics of sepsis and acute

respiratory distress syndrome. I have mentored three Emory School of Medicine Discovery students and worked with several fellows helping with their research projects.

Trainees who wish to work with me will be involved with managing and analyzing large healthcare databases and it is important to have some background in computer science, particularly in the SAS or R languages. Those seeking training in the MSCR program will achieve the sufficient background knowledge and skills for this. Even for trainees who do not work primarily with me, I am happy to serve in a limited role as a consultant to meet a few times and review your project”s study design, data management procedures, and overall goals for feasibly creating scientific output in fellowship. For those trainees with any interest at all in the MSCR, I”d also encourage you to set up a meeting with me to discuss the commitments, expectations, and other features of the program.

Primary Projects

· Cochi SE, Kempker JA, Annangi S, Kramer MR, Martin GS. Mortality Trends of Acute Respiratory Distress Syndrome in the United States from 1999 to 2013. Ann Am Thorac Soc. 2016 Oct;13(10):1742-1751. PubMed PMID: 27403914; PubMed Central PMCID: PMC5122485.

· Kempker JA, Honig EG, Martin GS. Effects of Marijuana Exposure on Expiratory Airflow: A Study of Adults who Participated in the U.S. National Health and Nutrition Examination Study. Annals of the American Thoracic Society. 2015 Feb;12(2):135-41

· Kempker JA, West KG, Kempker, RR, Siwamogsatham, Alvarez JA, Tangpricha V, Ziegler TR, Martin GS. A Prospective Observational Study of Vitamin D and Hospital-Acquired Infections in a Medical Intensive Care Unit. PLOS ONE. 2015 Apr 7;10(4):e0122136.

· Kempker JA, Magee MJ, Martin GS. Low Vitamin D is Associated with Increased Risk of Hospitalization with an Infection Among Medicare Beneficiaries. Am J Respir Crit Care Med 2015; 191: A1329 (poster and now under review at American Journal of Epidemiology)

Assisted Projects

· Staitieh BS, Saghafi R, Kempker JA, Schulman DA. Teaching a Hypothesis-driven Physical Diagnosis Curriculum to Pulmonary Fellows Improves Performance of First-Year Medical Students. Ann Am Thorac Soc. 2016 Apr;13(4):489-94. doi: 10.1513/AnnalsATS.201505-297OC. PubMed PMID: 26730644; PubMed Central PMCID: PMC5012696.

· Rajaram P, Parekh A, Fisher M, Kempker J, Subramanian R. Comparison of Post-Liver Transplantation Outcomes in Portopulmonary Hypertension and Pulmonary Venous Hypertension: A Single-Center Experience. Transplant Proc. 2017 Mar;49(2):338-343. doi: 10.1016/j.transproceed.2016.12.006. PubMed PMID: 28219595.

Michael Koval, PhD Professor of Medicine and Cell Biology Associate Division Director for Research

I have a long standing interest and expertise in studying cell membranes, with a particular emphasis in understanding the molecular basis for formation and remodeling of intercellular junctions. I received my Ph.D. in Cell Biology from Johns Hopkins University and was a Postdoctoral Fellow at Washington University. From there I became a faculty member in the Department of Physiology at the University of Pennsylvania with a joint appointment at the Institute for Environmental Medicine. About a decade ago I joined the Department of Medicine and Emory Alcohol and Lung Biology Center at Emory University. I also have a joint appointment in the Department of Cell Biology.

A major research direction in my lab is to understand how tight junctions regulate the pulmonary air/liquid barrier. We use molecular and cell biological approaches to define roles for several tight junction proteins (claudins, occludin, ZO-1, ZO-2) in normal lung barrier function and in pathologic conditions such as acute respiratory distress syndrome (ARDS). A long term goal of our research is to identify control points which augment barrier function as a means to improve the outcome of patients with ARDS and other forms of lung injury, particularly in the context of alcoholic lung syndrome and HIV-associated lung diseases. More recently, we have begun to examine the impact of Cystic Fibrosis (CF) on airway barrier function with particular emphasis on how the airway barrier and epithelial cell repair is impaired in CF-related diabetes.

Recent research projects with mentees (since 2010, mentees underlined):

• Koval, M., C. Ward, M.K. Findley, S. Roser-Page, M. N. Helms and J. Roman. 2010. Extracellular matrix influences alveolar epithelial claudin expression and barrier function, Amer. J. Respir. Cell Mol. Biol., 42:172-180. PMCID: PMC2822979

• Mitchell, L. A., C. E. Overgaard, C. Ward, S. S. Margulies and M. Koval. 2011. Differential effects of claudin-3 and claudin-4 on alveolar epithelial barrier function, Amer. J. Physiol. Lung Cell. Mol. Biol., 301:L40-49, PMCID: PMC3129905.

• Yoseph, B. Z. Liang, E. Breed, K. McConnell, D. M. Guidot, M. Koval and C. M. Coopersmith. 2013. Chronic Alcohol Consumption Increases Mortality in Sepsis, PLoS ONE 8:e62792. PMCID: PMC3661585

• Hunt, W. R., S. M. Zughaier, D. E. Guentert, M. A. Shenep, M. Koval, N. A. McCarty, and J. M. Hansen. 2014. Hyperglycemia impedes lung bacterial clearance in a murine model of cystic fibrosis-related diabetes. Amer. J. Physiol. Lung Cell. Mol. Biol., 306:L43-L49. PMCID: PMC3920212.

• Mitchell, L. A., C. Ward, M. Kwon, P. O. Mitchell, D. A. Quintero, A. Nusrat, C. A. Parkos and M. Koval. 2015. Junctional Adhesion Molecule A promotes epithelial tight junction assembly to augment lung barrier function. Amer. J. Pathol., 85:372-386. PMCID: PMC4305184

• Ward, C., B. L. Schlingmann, A. A. Stecenko, D. M. Guidot, M. Koval. 2015. NF-”B inhibitors impair lung epithelial tight junctions in the absence of inflammation. Tissue Barriers, 3:e982424. PMCID: PMC4372020

• Overgaard, C.E., B. Schlingmann, S. Dorsainvil White, C. Ward., X. Fan, S. Swarnakar, L. A. Brown, D. M. Guidot and M. Koval. 2015. The relative balance of GM-CSF and TGFß1 regulates lung epithelial barrier function. Amer. J. Physiol. Lung Cell. Mol. Biol., 308:L1212-1223. PMCID: PMC4499033

• Molina, S.A., B. Stauffer, H. K. Moriarty, A. Kim, N. A. McCarty, and M. Koval. 2015. Junctional abnormalities in human airway epithelial cells expressing F508del CFTR. Amer. J. Physiol. Lung Cell. Mol. Biol., 309:L475-87. PMCID: PMC4556929

Recent reviews / book chapters with mentees (since 2010)

• Mitchell, L. C. and M. Koval. 2010. Specificity of interaction between Clostridium perfringens enterotoxin and claudin-family tight junction proteins, Toxins, 2, 1595-1611. (peer reviewed)

• Overgaard, C. E., B. L. Daugherty, L. A. Mitchell and M. Koval. 2011. Claudins: Control of Barrier Function and Regulation in Response to Oxidant Stress, Antioxid. Redox. Signal., 15:1179-93. (peer reviewed, includes primary data). PMCID: PMC3144428.

• Overgaard, C.E., L.A. Mitchell, and M. Koval. 2012. Roles for claudins in alveolar epithelial barrier function. Annals of the New York Acad. Sci., 1257:167-174. (peer reviewed) PMCID: PMC3375852.

• Molina, S. A. and M. Koval. 2013. Alcohol and the Alveolar Epithelium. in Alcohol Use Disorders and the Lung: A Clinical and Pathophysiological Approach, David M. Guidot and Ashish J. Mehta, editors. Springer, pp 83-101.

• Koval, M., S. A. Molina and J. M. Burt. 2014. Mix and match: Investigating heteromeric and heterotypic gap junction channels in model systems and native tissues. FEBS Letters, Special Issue on Connexins, Pannexins and Innexins. 588:1193-1204 (selected as “Recommended” by F1000Prime).

• Schlingmann, B., S. A. Molina and M. Koval. 2015. Claudins: gatekeepers of lung epithelial function. Seminars in Cell Dev. Biol., 42:47-57.

• Schlingmann, B. L., C. Ward, S. A. Molina, C. E. Overgaard, D. M. Guidot and M. Koval. 2015. Alveolar Barrier Function in Alcoholic Lung Syndrome is Impaired by Tight Junction Destabilization. Annals of the Amer. Thoracic Soc., 12 Suppl 1:S75-6.

• Lab website: http://kovallab.org/

Frances Eun-Hyung Lee, MD Assistant Professor of Medicine Director, Asthma, Allergy, Immunology Program I came to Emory in 2012 as a Physician-Scientist in Pulmonary Immunology. With my unique expertise, my focus at Emory University was to build a three-pronged approach for excellence in (1) Translational Research, (2) Clinical

Service, and (3) commercialization of University technologies through small business opportunities.

In research, I have the expertise, leadership, and training in the biology of human blood antibody secreting cells (ASC) and BM plasma cells. As a translational scientist, I have focused my laboratory to study the human long-lived plasma cells (LLPC) in the bone marrow with the goal to understand novel intrinsic and extrinsic mechanisms of their survival. Our work identified the human LLPC phenotype using multi-color flow cytometry, morphology, and viral-specific Elispots from measles and mumps specific plasma cell responses in only one unique CD19-CD38hiCD138+ BM subset. Using a combination of next generation sequencing to follow VH clones in the plasma cell subsets combined with state-of-the art proteomics, we directly linked the of serum viral-antibodies to the one unique cellular compartment (LLPC) in the human BM. This work identifies the human LLPC compartment for the first time and provides the basis to identify novel mechanisms of plasma cell survival for the persistence of protective antibody secretion.

Within the past 3 years, I have also built the Adult Asthma Allergy and Immunology Program at Emory University with new clinical service line to provide state-of-the-art care for patients with severe asthma and complex allergic and immunological diseases. This program works closely with established expertise at Emory in Pediatric Immunodeficiency, Otolaryngology in the Rhinology and Voice Clinics, Interventional Pulmonary, and Dermatology. The goals of this program are to provide novel immune therapies through clinical trials and compassionate use. In addition to providing excellence in clinical care, I have developed a translational research program to understand the basic immune cellular mechanisms of IgE mediated allergic diseases with support from both NIH and Pharmaceutical research grants.

Lastly, I have been working at the interface of academic and small business enterprises to further commercialize university-based technologies with support from the Emory Technology Transfer Office, Georgia Research Alliance (GRA) programs, Center for Disease Control (CDC) and Small Business Innovative Research grants. We have been developing novel immune-based diagnostic methods for infectious diseases and new pharmaceutical research reagents to enhance antibody secretion and survival of plasma cells for the biologics industry.

Publications:

E. Morzycka-Wroblewska, F. E-H Lee, S.V. Desiderio, Unusual Immunoglobulin Gene Rearrangement Leads to Replacement of Recombinational Signal Sequences. Science 1988;242:261-263. PMID: 3140378

JE Snyder, WJ Bowers, AM Livingstone, F E-H Lee, HJ Federoff, TR Mosmann, Measuring the frequency of mouse and human cytotoxic T cells by the Lysispot assay: independent regulation of cytokine secretion and short-term killing. Nat Med. 2003 Feb; 9(2):231-6. PMID: 12539041

F. E-H Lee, EE Walsh, A Falsey, R Betts, J Treanor. Low Neutralizing Antibody Levels Increase Susceptibility to Respiratory Syncytial Viral Infection Using a Human Challenge Model. Antiviral Research March 2004; 63: 191-196. PMID: 15451187

*F. E-H Lee, EE Walsh, AR Falsey, N Liu, D Liu, A Divekar, JE Snyder, TR Mosmann, The Balance between Influenza- and RSV-specific CD4 T cells Secreting IL-10 or IFNg in Young and Healthy-elderly Subjects. Mech Ageing Dev, 2005 Nov. 126(11), 1223-1229. PMID: 16098562

AA Divekar, DM Zaiss, F-EH Lee, D Liu, DJ Topham, AJ Sijts, TR Mosmann, Protein Vaccines Induce a Higher Frequency of Uncommitted IL-2+IFNg- Mouse and Human Memory CD4 T cells, whereas Infection Induce More Effector IFNg+ Producing Cells. J Immunol, 2006 Feb 176(3) 1465-73. PMID: 16424174

*F. E-H Lee, ME Lumb, N Okam, N Liu, CB Hall, EE Walsh, AR Falsey, TR Mosmann, RSV-specific Cytokine Responses in Infants during Primary RSV Infection. J Infect Dis. 2007 Jun 15;195(12):1779-88. PMID: 17492594

C Wei, J Anolik, A Cappione, F. E-H Lee, E Milner, I Sanz, Identification of a novel population of human memory B cell lacking CD27 in the expansion of Systemic Lupus Erythematosis. J Immunol. 2007 May 15;178(10):6624-33. PMID: 17475894

JA Rebhan, C Bishop, AA Divekar, K Jiminez-Garcia, JJ Kobie, F E-H Lee, GM Maupin, JE Snyder-Cappione, DM Zaiss, TR Mosmann, Automated analysis of two- and three-color fluorescent Elispot (Fluorospot) assays for cytokine secretion, Computer Methods and Programs in Biomedicine 2008 Oct:92 (1) 54-65. Epub Jul 21 2008. PMID: 18644656

S Kyu, J Kobie , MS Zand, DJ Topham, SA Quataert, I Sanz, *F E-H Lee, Frequencies of Human Influenza-specific Antibody Secreting Cells or Plasmablasts post Vaccination from Fresh and Frozen PBMC, J Immunol Methods. 2009 Jan 1, 340 (1):42-7, Epub Nov 6, 2008. PMID: 18996127

TR Mosmann, JJ Kobie, F E-H Lee, S Quataert, T helper Cytokine Patterns: Defined Subsets, Random Expression and External Modulation. Immunological Research 2009 Dec;45(2-3):173-84. Feb 6, Epub Nov, 2008. PMID: 19198763

EJ Collarini, F. F-H Lee, O Foord, M Park, G Sperinde, H Wu, WD Harriman, SF Carroll, SL Ellsworth, BA Keyt, LM Kauvar: Potent High Affinity Antibodies for Treatment and Prophylaxis of Respiratory Syncytial Virus Derived from B Lymphocytes of Infected Patients. J Immunol. 2009 Nov 15;183(10):6338-45. Epub 2009 Oct 19, PMID: 19841167

C. B. Duncan, EE Walsh, DR Peterson, F. E-H Lee, AR Falsey, Risk Factors for Respiratory Failure Associated with RSV Infection in Adults. J Infect Dis Oct 15;200(8):1242-6, 2009, PMID: 19758094

J Halliley, S Kyu, J Kobie, EE Walsh, AR Falsey, T Randall, C Feng, I Sanz, *F. E-H Lee, Peak Frequencies of Antibody Secreting Cells ex vivo Occur on Day 5-8 and Correlates with Protective Antibody Titers after Human Influenza. Vaccine. 2010 Apr 30;28(20):3582-7. Epub 2010 Mar 16. PMID: 20298818

*F. E-H Lee, A Falsey, J Halliley, I Sanz, EE Walsh, Circulating Antibody Secreting Cells during Acute Respiratory Syncytial Virus Infection in Adults, J Infect Dis. 2010 Dec 1;202(11):1659-66. Epub 2010 Oct 27. PMID: 20979459

Y Qian, C Wei, F. E-H Lee, J Campbell, J Halliley, J A. Lee, J Cai, M Kong, E Sadat, E Thomson, P Dunn, AC Seegmiller, NJ Karandikar, C Tipton, T Mosmann, I Sanz, RH Scheuermann. Elucidation of Seventeen Human Peripheral Blood B-Cell Subsets and Quanti”cation of the Tetanus Response Using a Density-Based Method for the Automated Identi”cation of Cell Populations in Multidimensional Flow Cytometry Data. Cytometry B Clin Cytom. 2010;78 Suppl 1:S69-82. PMID: 20839340

F. E-H Lee, SN Georas, LA Beck, IL-17 “ Important for Host Defense, Autoimmunity and Allergy? J Invest Dermatol. 2010 Nov;130(11):2540-2. PMID: 20944637

*F. E-H Lee, J Halliley, B Kmush, A Falsey, R Miller, D Kaminski, T Randall, EE Walsh, I Sanz, Lack of Bystander Stimulation of Circulating Human Antibody Secreting Cells during Vaccinations and Acute Respiratory Viral Infections. JI 2011 May 1;186(9):5514-21. PMID: 21441455

MW LaMere, A Moquin, F. E-H Lee, PJ Blair, L Haynes, TD Randall, FE Lund, DA Kaminski Regulation of antiviral anti-nucleoprotein IgG by systemic vaccination and its effect on influenza virus clearance. J Virology 2011 May;85(10):5027-35. PMID: 21367900

F. E-H Lee, A Falsey, EE Walsh, The Effect of Steroids Use in Hospitalized Adults with Respiratory Syncytial Virus Related Illness, CHEST 140(5):1155-61 2011. PMID: 21565965

Kobie JJ, Zheng B, Bryk P, Barnes MR, Ritchlin C, Tabechian D, Anandarajah A, Looney RJ, Thiele R, Anolik J, Wei C, Rosenberg A, Feng C, Treanor J, Lee F E-H, Sanz I, Decreased influenza-specific B cell responses in Rheumatoid Arthritis Patients Treated with anti-TNF therapy. Arthritis Research and Therapy 13(6):R209, 2011. PMID: 22177419

Kaminiski DA, Wei C, Rosenberg A, Lee FE-H, Sanz I. 2012. Multi-parameter flow cytometry and bioanalytics for B cell profiling in systemic lupus erythematosus. Methods Mol Biol. 2012;900:109-34. PMID: 22933067

Walsh EE, Peterson DR, Kalkanoglu A, Lee FE, Falsey AR, Viral Shedding and Immune Responses to RSV infection in Older Adults, JID 2013 May;207(9):1424-32 Feb 19 [Epub ahead of print] PMID: 23382572

O'Connor TG, Winter MA, Hunn J, Carnahan J, Pressman EK, Glover V, Robertson-Blackmore E, Moynihan JA, Lee FE, Caserta MT, Prenatal maternal anxiety predicts reduced adaptive immunity in infants. Brain Behav Immun. 2013 Feb 21. doi:pii: S0889-1591(13)00116-5. 10.1016/j.bbi.2013.02.002. [Epub ahead of print] PMID: 23439080

Weaver JM, Yang H, Roumanes D, Lee FE, Wu H, Treanor JJ, Mosmann TR. Increase in IFN”(-)IL-2(+) Cells in Recent Human CD4 T Cell Responses to 2009 Pandemic H1N1 Influenza. PLoS One. 2013;8(3):e57275. doi: 10.1371/journal.pone.0057275. Epub 2013 Mar 20.PMID: 23526940

Rajan D, McCracken CE, Kopleman HB, Kyu SY, Lee FE, Lu X, Anderson LJ. Human rhinovirus induced cytokine/chemokine responses in human airway epithelial and immune cells. PLoS One. 2014 Dec 12;9(12):e114322. doi: 10.1371/journal.pone.0114322. eCollection 2014. PMID:25500821

Tipton C, Fucile, CF, Darce J, Ichikawa T, Chida A, Gregoretti, I, Schieferl S, Hom J, Jenks S, Feldman RJ, Mehr R, Wei C, Lee FE, Cheug WC, Rosenberg AF, Sanz I, Diversity, Cellular Origin, and Autoreactivity of Antibody-secreting cell Expansions in Acute SLE, Nat Immunol. 2015 Jul;16(7):755-65. doi: 10.1038/ni.3175. Epub 2015 May 25

Halliley JL, Tipton C, Liesved J, Rosenberg AF, Darce J, Gregoretti IV, Papova L, Kaminiski D, Fucile C, Albizua-Santin I, Kyu S, Chiang KY, Bradley K, Burack R, Slifka M, Hammarlund E, Wu H, Zhao L, Walsh EE, Flasey AR, Randall TD Cheun WC, Sanz I, *Lee FE, Identification of Long-lived Plasma Cells in Human Bone Marrow. Immunity. 2015 Jul 21;43(1):132-45. doi: 10.1016/j.immuni.2015.06.016. Epub 2015 Jul 14.PMID: 26187412.

Greg Martin, MD, MSc Professor of Medicine Associate Division Director for Critical Care Director of Research, Emory Critical Care Center

I completed my undergraduate studies at Duke University; medical school, residency and subspecialty fellowship training at Vanderbilt University and a post-graduate Master of Science degree at Emory University. I have worked

clinically in different settings since my arrival at Emory, and I am currently the section chief and MICU director at Grady. My career focus has been on conducting clinical research in critically ill patients, particularly those with sepsis and acute respiratory distress syndrome (ARDS) and building a team of faculty to work together on related projects and mentor students and trainees in conducting clinical critical care research. I also serve as the Director of Research for the Emory Center for Critical Care (ECCC), the Director of the Emory/Georgia Tech Predictive Health Institute and the affiliated Center for Health Discovery and Well Being, and Director for the Clinical Research Network as part of the Georgia Clinical and Translational Science Alliance (Georgia CTSA) led by Dr. W. Robert Taylor, Division Director of Cardiology.

Dr. Martin's personal research includes clinical and translational research in critically ill patients, with his primary interests being in sepsis, organ dysfunction syndromes and acute respiratory distress syndrome (ARDS). Dr. Martin has conducted work that spans epidemiology and health services research through biomarker trials to randomized, controlled treatment trials in critically ill patients. In his roles for both the Division and the ECCC, Dr. Martin helps to coordinate critical care research at Emory, including the Emory Program in Critical Care. Dr. Martin is clinically active in both pulmonary and critical care medicine and is an active teacher in the Pulmonary & Critical Care fellowship program.

Recent research projects with mentees

• Jordan Kempker, MD, MSc: “Vitamin D status and the risk for hospital-acquired infections in critically ill adults: a prospective cohort study.” Published in PLoS One and available here: http://www.ncbi.nlm.nih.gov/pubmed/25849649

• Carmen Polito, MD, MSc: “Prehospital recognition of severe sepsis: development and validation of a novel emergency medical services screening tool.” Published in Am J Emerg Med and available here: http://www.ncbi.nlm.nih.gov/pubmed/26070235

• Jordan Kempker, MD, MSc: “The effects of marijuana exposure on expiratory airflow. A study of adults who participated in the U.S. National Health and Nutrition Examination Study.” Published in Annals of the American Thoracic Society and available here: http://www.ncbi.nlm.nih.gov/pubmed/25521349

• Sarah Prebil, MD: “Safety of research bronchoscopy in critically ill patients” published in J Crit Care and available at: http://www.ncbi.nlm.nih.gov/pubmed/25092617

• Chris Seymour, MD, MSc (Pulmonary/CC fellow at University of Washington): “Marital status and the epidemiology and outcomes of sepsis.” Published in CHEST and available at: http://www.ncbi.nlm.nih.gov/pubmed/20173054

• Jenny Han, MD, MSc (Pulmonary/CC fellow): “Evaluating Simulation-Based ACLS Education on Patient Outcomes: A Randomized, Controlled Pilot Study.” Published in J Grad Med Educ and available at: http://www.ncbi.nlm.nih.gov/pubmed/25210581

• Ellen Smith: “Vitamin D deficiency is associated with anaemia among African Americans in a US cohort.” Published in Br J Nutr and available at: http://www.ncbi.nlm.nih.gov/pubmed/25876674

• Jessica Alvarez, PhD: “Vitamin D status is independently associated with plasma glutathione and cysteine thiol/disulfide redox status in adults.” Published in Clin Endocrin and available at: http://www.ncbi.nlm.nih.gov/pubmed/24628365

• Jared Greenberg, MD (IM resident): “Outcomes for critically ill patients with HIV and severe sepsis in the era of highly active antiretroviral therapy.” Published in J Crit Care and available at: http://www.ncbi.nlm.nih.gov/pubmed/22033058

• Caroline Tse, MD (IM resident): “Characteristics and Outcomes of HIV-Infected Patients With Severe Sepsis: Continued Risk in the Post-Highly Active Antiretroviral Therapy Era.” Published in Crit Care Med and available at: http://www.ncbi.nlm.nih.gov/pubmed/25853590

• Freny Nirappil, MD (IM resident): “Characteristics and outcomes of HIV-1-infected patients with acute respiratory distress syndrome.” Published in J Crit Care and available at: http://www.ncbi.nlm.nih.gov/pubmed/25466320

• David Berkowitz, MD (Pulmonary/CC fellow): “Alcohol Abuse Enhances Pulmonary Edema in Acute Respiratory Distress Syndrome.” Published in Alcohol Clin Exp Res and available at: http://www.ncbi.nlm.nih.gov/pubmed/19572988

• Carmen Polito, MD, MSc: “Navigating the institutional review board approval process in a multicenter observational critical care study.” Published in Annals of the American Thoracic Society and available here: http://www.ncbi.nlm.nih.gov/pubmed/24368345

• Jenny Han, MD: “Medical Outcomes in ACLS Knowledge (MOCK): The Effect of Standardized ACLS Simulation Training.” Published in the Journal of Graduate Medical Education.

• David Berkowitz, MD (Pulmonary/CC fellow): “Accurate characterization of extravascular lung water in acute respiratory distress syndrome.” Published in Crit Care Med and available at: http://www.ncbi.nlm.nih.gov/pubmed/18496374

• Recent reviews / book chapters with mentees: • Martin R, Esper AM, Martin GS. Hematologic Complications. In: Non-Pulmonary Complications of Critical Care. Richards JB and

Stapleton RD (eds). New York, NY. Springer New York, 2014, pp 135-163. • Soto GJ, Martin GS, Gong MN. Healthcare Disparities in Critical Illness. Crit Care Med 2013; 41(12): 2784-2793. • Polito C, Martin GS. Albumin: Physiologic and Clinical Effects on Lung Function. Minerva Anestesiol 2013; 79(10):1180-1186. • Neamu RF, Martin GS. Fluid management in acute respiratory distress syndrome. Curr Opin Crit Care 2013; 19(1):24-30.

Recent abstracts

• Kempker JA, Honig EG, Martin GS. The Effects of Marijuana Exposure on Respiratory Health in US Adults. Am J Respir Crit Care Med 2015; 191: A4025.

• Kempker JA, Magee MJ, Martin GS. Low Vitamin D is Associated with Increased Risk of Hospitalization with an Infection Among Medicare Beneficiaries. Am J Respir Crit Care Med 2015; 191: A1329.

• Husain AA, Ahmed AO, Amin OI, Berger M, Tomazic-Allen S, Brown M, Sevransky JE, Martin GS. Predictors Of Early Antibiotic Administration In Patients Suspected Of Sepsis. Am J Respir Crit Care Med 2015; 191: A3994.

• Ogbu OC, Martin GS, Sevransky JE, Murphy DJ. High Tidal Volumes Are Independently Associated With Development Of A Ventilator-Associated Condition In The ICU. Am J Respir Crit Care Med 2015; 191: A3117.

• Martin R, Martin GS, Harris F, Brown L, Esper AM. The Rage Signaling Pathway In Sepsis-Induced ARDS: Role Of HMGB1 And MMPs. Am J Respir Crit Care Med 2015; 191: A2372.

• Cribbs SK, Rojas M, Taylor R, Sutcliffe D, Brigham KL, Martin GS. Circulating endothelial progenitor cells are inversely associated with respiratory organ dysfunction in sepsis. Crit Care Med 2008; 36(12S): A76.

• Sevransky J, Mendez-Tellez P, Brower R, Pronovost P, Needham D, Martin GS, Shanholtz C. Sepsis is not independently associated with mortality in acute lung injury. Crit Care Med 2008; 36(12S): A78.

• Martin GS, Park Y, Jones DP. Metabolomic profile of albumin therapy in acute lung injury. Proc Am Thorac Soc 2008; 177: A40. • Prout ME, Guidot DM, Martin GS. Rate of alcohol use assessment in patients admitted to a medical ICU and recognition of

alcohol use disorders. Proc Am Thorac Soc 2008; 177: A113.

Ashish Mehta, MD, MSc Assistant Professor of Medicine Director, Atlanta VA Medical Center Medical Intensive Care Unit

I have been at Emory since 2003, when I started my intern year. I completed residency and fellowship in the Emory program and joined the faculty of the VA section in 2009 with a funded 2-year career development grant. I completed the Masters of Science in clinical research (MSCR) program in 2013 and received a 5-year career

development award grant from the VA. My research involves clinical translational projects evaluating the role of alcohol abuse in predisposing individuals to pneumonia and acute lung injury. Specifically, I investigate the role of zinc deficiency and oxidative stress

on alveolar macrophage immune function and am in the middle of a large 5 year randomized clinical trial evaluating the role of dietary antioxidants and zinc on lung immune function.

I have not previously worked with fellows, but would be available as a secondary mentor and for collaboration on projects that involve the role of alcoholism in lung disease. I have co-mentored medical students who work in the laboratory setting and I have a strong interest in clinical research. I am the medical director of the MICU at the VA and have a strong clinical interest in critical care ultrasound. I have experience with writing IRB protocols and would be available as a resource or mentor for any fellows who may have an idea for a research project.

Recent research project with mentee Middour T, Fan X, and Mehta A. Treatment with s-adenosylmethionine and zinc restores Nrf2 and Nrf2-antioxidant response element dependent gene expression in alcohol-treated alveolar macrophages in vitro. Journal of Investigative Medicine. Vol 62(2), P. 542, 2014. Presented at South Society of Clinical investigation meeting, New Orleans, Louisiana, 2014 (oral presentation).

Recent book

• Guidot DM and Mehta AJ, editors. Alcohol Use Disorders and the Lung: A Clinical and Pathophysiological Approach, Humana Press, 2014. ISBN-10: 146148832X

Other recent manuscripts

• Mehta AJ, Yeligar SK, Elon L, Brown LA, Guidot DM. Alcoholism Causes Alveolar Macrophage Zinc Deficiency and Immune Dysfunction. Am J Respir Crit Care Med, Vol. 188, No. 6, pp. 716-23, 2013 PMID: 23805851, PMCID: PMC3826184

• Mehta AJ, Guidot DM, and Weber KT. Alcohol Abuse, the Alveolar Macrophage and Pneumonia. Am J Med Sci, 2012 Mar;343(3):244-7. PMCID: PMC3288531

David J. Murphy, MD, PhD Assistant Professor of Medicine Patient Safety Officer, Emory Healthcare Director of Research, Emory Healthcare Office of Quality Director of Quality, Emory Critical Care Center

I joined the Emory University faculty in 2011 where I enjoy pursuing my passion for improving healthcare quality and patient safety through a variety of clinical, administrative, and research activities. Prior to coming to Emory, I completed my undergraduate education at Johns Hopkins University; medical school at New Jersey Medical School, Internal Medicine residency at Robert Wood Johnson Medical School; and pulmonary critical care fellowship training at the Johns Hopkins University. While a fellow at Johns Hopkins, I also completed my doctor of philosophy in Clinical Investigation from the Bloomberg School of Public Health. My research focuses on advancing healthcare quality and patient safety by improving the translation of evidence into practice. I apply a range of clinical research and health services research methods to better evaluate healthcare delivery and outcomes, to assess barriers to best practices, and to improve healthcare delivery across organizations. Several of my clinical research areas include healthcare associated conditions, transfusion medicine, sepsis, and acute respiratory distress syndrome (ARDS).

Recent mentees (medical students/physicians):

• Ananda Chowdhury, MD: Mentored as resident in internal medicine; now a pulmonary fellow at Cleveland Clinic • Michael Evans, MD: Mentored as medical student; now a resident in internal medicine at Emory • Husam Kheir, MD: Mentored as research volunteer; now a medical student at NYU • Peter Lyu, MSPH: Mentored as Rollins School of Public Health MSPH student; now a PhD candidate at Harvard University • Lacey Loomer, MSPH: Mentored as Rollins School of Public Health MSPH student; now a PhD candidate at Brown University • Kevin Seitz MD, MSc: Mentored as medical student and clinical investigation (MSc) student; now a resident in internal medicine

at University of Washington

• Ogbonna Ogbu, MBBS, MSc: Mentored as fellow in pulmonary and critical care and clinical investigation (MSc) student; now physician and critical care quality leader at Piedmont Health

• Michelle Ossmann, RN, MSN, PhD: Mentored as doctoral student in Georgia Tech School of Architecture; now Director of Healthcare Environments at Steelcase Health

• Casey Cable, MD: Mentoring as a pulmonary and critical care fellow, and a Masters in Clinical Investigation student • Byron Crowe: Mentoring as a medical student

Recent peer-reviewed publications with mentees (in italics):

• Lyu PF, Murphy DJ. The Economics of Fluid therapy in Critically Ill Patients. [Review] Current Opinion in Critical Care 2014; 20(4): 402-407. PMID: 24979711

• Murphy DJ, Ogbu OC, Coopersmith CM. ICU Director Data: Using data to assess value, inform local change, and relate to the external world. [Review] Chest 2015; 147 (4): 1168-1178. PMID: 25846533

• Ogbu OC, Murphy DJ, Martin GS. How to Avoid Fluid Overload. [Review] Current Opinion in Critical Care 2015; 21(4): 315-21. PMID: 26103147

• Ogbu OC, Martin GS, Murphy DJ. A Few mL”s of Prevention: Lung Protective Ventilation Decreases Pulmonary Complications. [Invited Editorial] Critical Care Medicine 2015; 43(10):2263-4. PMID: 26376257

• Murphy DJ,Lyu PF, Gregg SR, Martin GS, Hockenberry JM, Coopersmith CM, Sterling M, Buchman TG, Sevransky J. Using incentives to improve resource utilization: a Quasi-experimental evaluation of an ICU quality improvement program. Critical Care Medicine 2016; 44(1):162-170. PMID: 26496444.

• Lyu PF, Hockenberry JM, Gaydos LM, Howard DH, Buchman TG, Murphy DJ. Impact of a Sequential Intervention on Albumin Utilization in Critical Care: a Quasi-experimental Study. Critical Care Medicine 2016; 44(7): 1307-1313. PMID: 26963324

• Seitz K, Sevransky JE, Martin GS, Roback JD, Murphy DJ. Restrictive Transfusion Protocols in Critical Care: Do They Affect Transfusion Practice? Critical Care Medicine 2016; (In Press). PMID: 27632673

• Polito CC, Bloom I, Yancey AH, Lairet JR, Isakov AP, Martin GS, Patel A, Rajasekar S, Pratt D, Wolfosky K, Hanfelt J, Murphy DJ, Sevransky JE. Pre-hospital sepsis care: understanding provider knowledge, behaviors, and attitudes. 2016 (In Press)

Recent posters and presentations with mentees (in italics):

• Ahmed H, Husain A, Martin GS, Sevransky J, Murphy, DJ. Process of care elements associated with the failure to provide lung protective ventilation for patients with ARDS. Chest 2013: 375A.

• Ogbu OC, Martin GS, Sevransky JE, Murphy DJ. High tidal volumes are independently associated with development of a ventilator associated condition in the ICU (Abstract) American Thoracic Society 2015: A3117.

• Lyu PF, Murphy DJ, Hockenberry J, Gaydos L, Howard D. Impact of financial incentives and guideline discussions on decreasing albumin use in critical care. (Poster) Georgia Public Health Association 2014.

• Seitz K, Sevransky J, Roback JD, Murphy, DJ. Restrictive Transfusion Protocols in Critical Care: Structural ICU Factors and Inappropriate Transfusions (Abstract) American Academy of Blood Banks 2015. Transfusion 2015: 55 (S3): SP296.

• Seitz K, Sevransky J, Martin GS, Roback JD, Murphy, DJ. Restrictive Transfusion Protocols in Critical Care: Can Structural ICU Factors Affect Transfusion Practice? (Abstract) Society of Critical Care Medicine 2016. Critical Care Medicine 2015; 43 (12 Supplement 1): 194.

• Lahsaei P, Loomer L, Groff R, O”Reilly-Shah VN, Murphy DJ, Blum JM. Peri-operative surgery adherence to the 3-hour sepsis bundle. (Abstract) Anesthesiology 2016.

• Polito CC, Bloom I, Yancey A, Lairet J, Murphy DJ, Martin GS, Sevransky JE. Improving prehospital recognition of severe sepsis (PRESS): knowledge and attitudes of first responder. (Abstract) International American Thoracic Society Conference 2016: A7617.

• Holder AL, Murphy DJ, Overton EC, Lyu P, Martin GS, Buchman TG. Organ failure data over time in the critically ill: At what cost, and to what benefit? (Abstract) Society of Critical Care Medicine 201

Ramzy H. Rimawi, MD Assistant Professor of Medicine After completing my training in Infectious Diseases and Critical Care Medicine, I came to Emory as a clinical educator in 2014. My current clinical focus involves nosocomial infections, infection control and antibiotic stewardship in the ICU. During my fellowship, I focused on strengthening antibiotic stewardship efforts through penicillin skin testing and taught hundreds of medical students,

residents, pharmacists, fellows, faculty, and nurses how to properly perform and interpret the procedure. This instrument became widely used at Vidant Medical Center to improve antibiotic stewardship efforts and dramatically reduce healthcare costs.

I also held teaching seminars for ICU providers on optimal antimicrobial therapies for certain diagnoses based on up-to-date guidelines and evidence based research. I wrote and edited a book, Bedside Critical Care Guide, in which I helped teach medical students, residents, and fellows how to write book chapters in scholarly texts. I was heavily involved in teaching medical students, residents, and fellows common procedures performed in the ICU. I also enjoy teaching trainees the basics of microbiology and antimicrobial pharmacology. My teaching in these areas have been recognized and I have gratefully been awarded for these projects. As I am still in the beginning of my career, I am actively involving myself in a variety of research projects, teaching opportunities, and institutional committees.

Trainees who wish to work with me should have an interest in proposing, creating, implementing and measuring the effectiveness of novel techniques in education. While the ideal domain for this education would be in infectious disease and critical care or evidence-based medicine, I am willing to help negotiate with School of Medicine leadership if your passion lies in another area.

Recent research projects with mentees:

• NYU Lutheran Prasad Award of Teaching Resident of the Year, 2010-2011 • NYU Lutheran Prasad Award of Teaching Resident of the Year, 2011-2012 • North Carolina Infectious Disease Society Best Research Travel Award, 2012-2013 • 27th Annual Yash Kataria Research Day Young Trainee Award, 2014 • Rimawi RH, Mazer M, Kabchi B, Ashraf M, Gooch M, Cook P. The Impact of Daily Collaboration Between Critical Care and

Infectious Disease Specialists on Adherence to Guidelines and Antibiotic Use in the Medical Intensive Care Unit. IDSA/NIAID Fellow’s Career Meeting. Bethesda, MD. June 2013

Recent reviews / book chapters with mentees

• Rimawi RH, Cook PP. Multidrug-resistant gram-negative bacteria. In: Gantz’s Manual of Clinical Problems in Infectious Diseases, 6th Edition. Myers JW, Moorman JP, Salgado CD. Philadelphia, PA. Lippincott Williams & Wilkins, 2012: 301-305.

• Bedside Critical Care Medicine Guide. Rimawi RH. OMICS Group Inc. January 2014. http://www.esciencecentral.org/ebooks/bedside-critical-care-guide

Other recent manuscripts

• Rimawi RH, Ashraf M, Kabchi B, et al. The impact of penicillin skin testing on clinical practice and antimicrobial stewardship. Journal of Hospital Medicine. 2013. Jun; 8(6): 341-345.

• Rimawi RH, Mazer MA, Siraj D, Gooch M, Cook PP. The impact of regular collaboration between Infectious Diseases and Critical Care practitioners on antimicrobial utilization and patient outcome. Critical Care Medicine. 2013. Sep; 41(9): 2099-107.

• Rimawi RH. Just Say "Stop" - Avoiding Prolonged Empiric Antibiotics. Crit Care Med. 2015 Dec; 43(12): 2675-2676. • Rimawi RH. Can A Lack of ESBL-Producing Enterobacteriaceae Rectal Carriage Help Avoid Carbapenem Prescription? Crit Care

Med. 2015. In press.

Ruxana T Sadikot, MD, MRCP (UK) Professor of Medicine, Emory University Section chief, Pulmonary and Critical Care, Atlanta VAMC I joined the Division of pulmonary and critical care medicine at the Emory University in July 2014 and currently serve as the section chief at the Atlanta VAMC. For most of my career as a faculty I have worked on research projects with

graduate and medical students, residents and fellows. I was the Associate Director for the Pulmonary Fellowship program at the University of Illinois in Chicago (2005-2012) and played an active role in clinical and research training of residents and fellows. Extramurally I have served as a member of transition and training (MITT) committee of the American Thoracic Society (2007-2015) and was an executive member of the American Lung Association in Chicago (2006-2012) where I was responsible for organizing research seminars for students, residents and fellows. My mentees have presented abstracts at National and International meetings and have successfully published case reports, reviews and original research articles.

The overarching focus of my research is defining lung immune response and mechanisms of lung injury. I am currently funded by the Department of Veterans affairs. In particular my laboratory is focused on understanding the host pathogen interactions in difficult to

treat infections such as P.aeruginosa, Achromobacter and NTM. We study the role of lipid mediators (prostaglandins)/PPAR” signaling and superimmunoglobulin receptor TREM-1 in macrophages in lung infections. By defining the immune response we aim to develop immunomodulatory strategies in patients with difficult to treat or resistant infections. My clinical interests include infections in patients with non-CF bronchiectasis and select immunocompromised patients. I have mentored several graduate students, residents, post- doctoral fellows and junior faculty through my career.

Selected recent publications with mentees (for a full list Pubmed Sadikot R):

• Mehdi M, Sadikot RT. Gender susceptibility in non- mycobacterial disease. Int J Mycobacteriol. 2015 Jun;4(2):92-96 • Swenson C and Sadikot RT. Achromobacter respiratory infections. Ann American Thoracic Society 2015 Feb;12(2):252-8 • Mehta H, Patel V, Sadikot RT. Curcumin and Lung Cancer a review Target Oncol. 2014 Dec; 9(4):295-310. • Hadid W, Rafoi D, Davis O and Sadikot RT. A 45 year old woman with acquired immunodeficiency syndrome and lung mass

Chest 2014 Jan;145(1):173-7. • Patel V, Mehta HJ, Sadikot RT. Pulmonary artery dissection and rupture in a patient with idiopathic pulmonary artery

hypertension. Am J Resp Crit Care Med 2014 Mar 15;189(6):e10-1. • Yuan Z, Mehta H, Roman R, Mohhammed K, Najmunissa N, Brantly M, Sadikot RT. • TREM-1 is induced in tumor associated macrophages by cyclo-oxygenase pathway in non-small cell lung carcinoma. PlosOne

2014 May 19;9(5):e94241. • Yuan Z, Syed MA, Panchal D, Joo M, Colonna M, Brantly ML, Sadikot RT.TREM-1 mediated Bcl2 induction prolongs macrophage

survival. J Biol Chem. 2014 May 23;289(21):15118-29 • Yuan Z, Panchal D, Syed MA, Mehta H, Joo MA, Hadid W, Sadikot RT. Induction of COX-2 signaling by S Mucilaginosus highlights

the pathogenic potential of an oral commensal J Immunol 2013 Oct 1;191(7):3810-7.

David Schulman, MD, MPH Professor of Medicine Associate Division Director for Education Director, Pulmonary and Critical Care Medicine Fellowship

I came to Emory in 2001 as a clinician educator. Since then, I have served as medical director of the Emory Sleep Laboratory; my current clinical focus is on the diagnosis and management of sleep disorders as part of the Emory Sleep

Center. From the beginning of my Emory career, I have taken an active role in the training of pulmonary and critical care medicine fellows, and took over the role of Program Director in 2006. In addition to my work with post-graduate trainees, I direct the undergraduate medical curricula in evidence-based medicine and pulmonary disease, and serve on a number of institutional committees related to education, including the Progress and Promotions Committee and the Executive Curriculum Committee of the School of Medicine. Extramurally, my work in education has been recognized with a Fellows Education Award from the American Thoracic Society and the Parker J. Palmer Courage to Teach Award from the Accreditation Council for Graduate Medical Education.

My area of scholarly interest is in identifying and validating optimal methods of teaching and assessment, as is evidenced by my recent mentorship of fellows, residents and students, as documented below. Trainees who wish to work with me should have an interest in proposing, creating, implementing and measuring the effectiveness of novel techniques in education. While the ideal domain for this education would be in pulmonary medicine or evidence-based medicine, I am willing to help negotiate with School of Medicine leadership if your passion lies in another area.

Recent research projects with mentees

• Nikita Desai, MD: "Gender Differences in Residency Evaluations." • Nikita Desai, MD: "Assessing Medical Students' Clinical Reasoning Using Oral Examinations." Presented at CHEST 2017, Toronto,

Canada. • Bashar Staitieh, MD, and Ramin Saghafi, MD: “A Hypothesis-Driven Physical Diagnosis Curriculum for Pulmonary Fellows

Improves Performance of Medical Students.” Accepted for publication in the Annals of the American Thoracic Society. • Saumya Gurbani (MD, PhD student): “Retrospective Analysis of Time-of-Day vs. Student Performance on Medical School

Exams.”

• John Diehl and Ryan Smith (MD students): “Use of Supplemental Resources during the Foundations Phase of the Undergraduate Medical Curriculum.”

• Kelly Arps (MD student): “Creating Novel Teaching Materials for an Undergraduate Evidence-Based Medicine Curriculum.” Published two separate teaching aids on MedEdPortal.

• Jenny Han, MD: “Medical Outcomes in ACLS Knowledge (MOCK): The Effect of Standardized ACLS Simulation Training.” Published in the Journal of Graduate Medical Education.

Recent reviews / book chapters with mentees

• "Recommended Reading from the Emory University Pulmonary and Critical Care Medicine Research Fellows: Recent Advances in Lung Immunobiology." Richard P. Ramonell, Zohra Prasla, Charles R. Terry, David A. Schulman, and Frances Eun-Hyung Lee. In press in the American Journal of Respiratory Cell and Molecular Biology.

• "Inpatient management of sleep apnea." Lee, J-Y and Schulman DA. In Principles and Practices of Hospital Medicine, second edition.

• "The appearance of central sleep apnea after treatment of obstructive sleep apnea." Hoffman M, Schulman DA. Chest. 2012 Aug;142(2):517-22.

• "Obstructive sleep apnea and cardiovascular disease." Green DE, Schulman DA. Curr Treat Options Cardiovasc Med. 2010 Aug;12(4):342-54.

Other recent manuscripts

• "A Sleep Medicine Curriculum for Pulmonary and Pulmonary/Critical Care Fellowship Programs: A Multisociety Expert Panel Report." Schulman DA, Piquette CA, Alikhan MM, et al. Chest. 2019 Mar;155(3):554-564.

• "Measuring Fellows' Willingness to Challenge Authority Using an Objective Structured Clinical Examination." Schulman DA, Holder A, Fugate K, Timmer M, Wright W, Esper A. Chest. 2017 152(4): A563.

• "Growth in Social Media and Live-Tweeting at Major Critical Care Conferences: Twitter Analysis of the Past Four Years." Khan R, Kashyap R, Bhar A, Schulman D, Bruno K, Carroll C. Chest. 2017 152(4): A547.

• "Organization and structure for sleep medicine programs at academic institutions: Part 1--current challenges." Chervin RD, Chesson AL Jr, Benca RM, Greenough GP, O'Hearn DJ, Auckley DH, Littner M, Mullington JM, Malhotra A, Berry RB, Malhotra RK, Schulman DA. Sleep. 2013 Jun 1;36(6):795-801.

• "Organization and structure for sleep medicine programs at academic institutions: Part 2--goals and strategies to optimize patient care, education, and discovery." Chesson AL Jr, Chervin RD, Benca RM, Greenough GP, O'Hearn DJ, Auckley DH, Littner M, Mullington JM, Malhotra A, Berry RB, Malhotra RK, Schulman DA. Sleep. 2013 Jun 1;36(6):

• "Continuous positive airway pressure treatment of sleepy patients with milder obstructive sleep apnea: results of the CPAP Apnea Trial North American Program (CATNAP) randomized clinical trial." Weaver TE, Mancini C, Maislin G, Cater J, Staley B, Landis JR, Ferguson KA, George CF, Schulman DA, Greenberg H, Rapoport DM, Walsleben JA, Lee-Chiong T, Gurubhagavatula I, Kuna ST. Am J Respir Crit Care Med. 2012 Oct 1;186(7):677-83. doi: 10.1164/rccm.201202-0200OC. Epub 2012 Jul 26.

Jon Sevransky MD, MHS Professor of Medicine Director, EUH MICU Assistant Director, Emory Center for Critical Care

My clinical, administrative and research interests center around the treatment of patients with life threatening illness. In addition to my administrative roles at Emory, I serve as the associate editor for the journal Critical Care Medicine,

the editor for the Society for Critical Care Medicine’s podcasts, section lead for the mechanical ventilation and sedation for the Surviving Sepsis Campaigns, associate chair for the United States Critical Illness and Injury Trials Group, and chair of the Internal Medicine section of the society for Critical Care Medicine I have mentored more than 15 medical students, residents, fellows and junior faculty.

My primary research interests are in the treatment of patients with sepsis and the complications of sepsis including sepsis induced Acute Respiratory Distress Syndrome and septic shock. This includes both clinical trials, implementation science work (with David Murphy), attempts to identify sepsis patients in the prehospital phase (with Carmen Polito) and attempts with limit the development of ARDS in sepsis patients. I have also recently led, with Greg Martin as co-PI , a multicenter study looking at the association of ICU

structure and organization with in patient mortality. This work has led to some interest in examining factors that might modify effects of novel agents in clinical trials, and we are currently exploring ancillary studies from this database. A third new interest (with Mike Lava) focuses around identifying more patient centered outcomes for critical care trial primary outcome measures.

Recent research projects with mentees

• Carmen Polito, MD, Blake Anderson MD, Prehospital Identification of patients with severe sepsis: development and validation of a novel screening tool Am J Emergency Med in press

• Carmen Polito, MD, Blake Anderson, MD Vaishnavi Kundel MD, Kevin Wilson MD candidate Patient factors associated with identification of sepsis in the ED. Am J Emerg Med. 2014

• Carmen Polito MD Navigating the Review Board Approval Process in a Multicenter Observational Critical Care Study Crit Care Med 2014;1105-9.

• Carmen Polito MD Confronting ethical and regulatory complexity to advance pre-hospital sepsis research- under review • David Murphy MD, PhD Using Incentives to quality while reducing cost: a Quasi-experimental evaluation of an ICU quality

improvement program Critical Care Medicine 2015 in Press • David Murphy MD PhD Development of a Core Clinical Dataset to Characterize Serious Illness, Injuries and

Resource Requirements for Acute Medical Responses to Public Health Emergencies Crit Care Med 2015 in press • Amy Knight MD , Olefumi Falade MD, Factors Associated with Medication Warning Acceptance for Hospitalized Adults J Hosp

Med 2015;10:19-25. • Raghu Seethala MD Early risk factors and the role of fluid administration in developing the acute respiratory distress syndrome

in septic patients- submitted • Jessie Chai MD What is a Full Time Equivalent for a Critical Care Physician under review

Other recent manuscripts 2014-2015

• Fan, E , Dowdy DW, Colantuoni E, Mendez-Tellez PA, Sevransky JE, Shanholtz C, Himmelfarb CRD, Desai SV, Ciesla N, Herridge MS, Pronovost PJ, Needham DM. Physical complications in acute lung injury survivors: a 2-year longitudinal prospective study. Crit Care Med 201442:849-859.

• Checkley W, Martin GS, Brown SM, Chang SY, Dabbagh O, Girard TD, Rice TW, Howell MD, Johnson SB, O”Brien J, Park PK, Putman M, Rotello L, Siner J, Sajid S, Murphy DJ, Sevransky JE Structure, process and annual intensive care unit mortality across 69 center: United States Critical Illness and Injury Trials Group Critical Illness Outcomes Study ( USCIITG-CIOS) Crit Care Med 2014;344-56

• Decker BK, Sevransky JE, Barrett K, Davey RT, Chertow DS Preparing for critical care service to patients with Ebola Ann Int Med 2014 161:831-2

• Needham DM, Yang T, Dinglas VD, Mendez-Tellez PA, Shanholtz C, Sevransky JE, Brower RG, Pronovost PJ, Colantuoni E. Timing of Low Tidal Volume Ventilation and ICU Mortality in ARDS:A Prospective Cohort Study. American Journal of Respiratory and

• Sevransky JE, Checkley W, Herrera P, Pickering BW, Barr J, Brown SM, Chang SY, Chong D, Kaufman D, Fremont RD, Girard TD, Hoag J, Johnson SB, Kerlin MP, Liebler J, O”Brien J, O”Keefe T, Park PK, Pastores SM, Patil N, Pietropaoli AP, Putman M, Rice TW, Rotello L, Siner J, Sajid S, Murphy DJ, Martin GS Protocols and Hospital Mortality in Critically ill Patients: The United States Critical Illness and Injury Trials Group Critical Illness Outcomes Study Critical Care Medicine in press

• Sueblinvong V Johnson DW, Weinstein GL, Connor M, Crozier I, Liddell AM, Franch HA, Wall BR, Kalil AC, Feldmen M, Lisco SJ, Sevransky JE Critical Care of Patients with Multisystem Organ Failure Secondary To Ebola Virus Disease, Critical Care Medicine In press

Viranuj Sueblinvong, MD Assistant Professor of Medicine Associate Director, Emory Adult Cystic Fibrosis Program

I came to Emory in late of 2008 to establish basic science research program. My current research focus is on understanding the mechanism by which alcohol and/or aging predispose the lung toward fibroproliferative repair following acute lung injury in mice. My clinical focus is on caring for adults with Cystic Fibrosis. We have multi-

disciplinary approach to improving care for these patients both in and out of the hospital.

Recent research publication with mentees

• Viranuj Sueblinvong, V. Eric Kerchberger (MD student), Ramin Saghafi (Medical Resident, Pulmonary Fellow), Stephen T. Mills, Xian Fan, David M. Guidot. Chronic alcohol ingestion primes the lung for bleomycin-induced fibrosis in mice. Alcoholism: Clinical and Experimental Research. 2014 Feb;38(2):312-5. PMID 24033682.

• Sueblinvong V, Neveu WA (Pulmonary Fellow), Neujahr DC, Mills ST, Rojas M, Roman J, Guidot DM. Aging promotes pro-fibrotic matrix production and increases fibrocyte recruitment during acute lung injury. Adv Biosci Biotechnol. 2014 Jan;5(1):19-30. PMID 24596659.

• Viranuj Sueblinvong, Victor Tseng (Medical Resident, now a Pulmonary Fellow), Ramin Saghafi (Medical Resident, Pulmonary Fellow), Stephen T. Mills, David C. Neujahr, and David M. Guidot. TGFb1 mediates alcohol-induced Nrf2 suppression in lung fibroblasts. Alcoholism: Clinical and Experimental Research. 2014 Nov;38(11):2731-42. PMID 25421510.

• Wendy Neveu (Pulmonary Fellow), Stephen T. Mills, Bashar Staitieh, Viranuj Sueblinvong. TGFß1 epigenetically modifies Thy-1 expression in primary lung fibroblasts. American Journal of Physiology “ Cell 2015 (In press).

Abstracts presented at national and international meetings with mentees:

• V. Eric Kerchberger, Xian Fan, Ramin Saghafi, Steven T. Mills, David M. Guidot, Viranuj Sueblinvong. Chronic alcohol ingestion enhances lung fibrosis following bleomycin-induced lung injury in mice. Presented at 2012 Southern Society for Clinical Investigation Regional Meeting. Feb 2012. New Orleans, LA.

• Ramin Saghafi, Xian Fan, Viranuj Sueblinvong, David Guidot. Treatment with Sulforaphane, an activator of Nrf2, prevents alcohol-induced transforming growth factor-ß1 expression in mouse fibroblasts. Presented at 2012 Southern Society for Clinical Investigation Regional Meeting. Feb 2012. New Orleans, LA.

• Viranuj Sueblinvong, Ramin Saghafi, V. Eric Kerchberger, Steven T. Mills, Xian Fan, David M. Guidot. Alcohol induces TGFß1 expression via suppression of Nrf2 in vitro. Presented at 2012 ATS/ALA meeting, San Francisco, CA. May 2012. American Journal of Respiratory and Critical Care Medicine;185:A1266.

• V Sueblinvong, R Saghafi, ST Mills, X Fan, DM Guidot. Alcohol induces lung fibroblast oxidative stress via TGFß1 activation and Nrf2 suppression in vitro. Presented at 2013 SSCI meeting, New Orleans, LA. Feb 2013.

• Bashar Staitieh, Ramin Saghafi, Stephen T Mills, Xian Fan, David M Guidot, Viranuj Sueblinvong. Alcohol-induced oxidative stress in lung fibroblasts appears to involve an imbalance between Nrf2 and thioredoxin-1 in the nuclear compartment. Presented at 2013 ATS/ALA meeting, Philadelphia, PA. May 2013.

• WA Neveu, ST Mills, V Sueblinvong. Transforming growth factor beta 1-induced epigenetic modification of Thy-1 in primary lung fibroblasts. Presented at 2014 Annual Meeting of the Southern Society for Clinical Investigation, New Orleans, LA. Feb 2014.

• WA Neveu, ST Mills, V Sueblinvong. Transforming growth factor beta 1-induced epigenetic modification of Thy-1 in primary lung fibroblasts. Presented at 2014 ATS/ALA meeting, San Diego, CA. May 2014.

• Viranuj Sueblinvong, Stephen T. Mills, David M. Guidot. Nuclear over-expression of thioredoxin-1 protects against alcohol-induced lung fibroblasts-myofibroblast transdifferentiation. Alcohol 2014;48:727-734 (abstract 25).

• Victor Tseng, S. Todd Mills, David M. Guidot, Viranuj Sueblinvong. ATF3 expression correlates with chronic but not acute alcohol-mediated suppression of Nrf2-ARE activity by TGFß1. Presented at 2014 ATS/ALA meeting, San Diego, CA. May 2014.

• Neveu W, Mills S, Staitieh B, Sueblinvong V. TGFß1 regulates myofibroblast transdifferentiation in the lung by Thy-1 methylation. Presented at 2015 Annual Meeting of the Southern Society for Clinical Investigation, New Orleans, LA. Feb 2015.

• Neveu W, Mills S, Staitieh B, Sueblinvong V. TGFß1 regulates myofibroblast transdifferentiation in the lung by Thy-1 methylation. Presented at 2015 ATS/ALA meeting, Denver, CO. May 2015.

Roy L. Sutliff, PhD Associate Professor of Medicine Faculty Associate for International Programs, Laney Graduate School

I came to Pulmonary Division at Emory in 2005 as an Assistant Professor. Since arriving at the Pulmonary Division, I have been consistently funded by the NIH and other Research Foundations. I am very active in the Molecular and Systems Pharmacology Program that is part of the Graduate Division of Biological and Biomedical Sciences and serve

on the Executive Board. In addition to my research, I oversee the International Programs of the Laney Graduate School and am active in international recruiting and developing international exchanges.

My area of research interest is in cardiovascular pathophysiology. Vascular reactivity is a major determinant of physiological parameters such as blood pressure. Constriction of the vessel results in an increased blood pressure whereas, dilation of the vessel decreases blood pressure. Endothelial cells line the blood vessel and can regulate diameter of blood vessels by releasing agents that constrict or relax vascular smooth muscle cells. Research in my laboratory focuses on examining the interaction between endothelial cells and vascular smooth muscle cells and how certain pathophysiological conditions impair vascular function. The four areas that are most heavily studied are 1) the mechanisms of pulmonary vascular disease and accelerated atherosclerosis in HIV infection; 2) the role of PPARg and its subsequent effects on NADPH oxidases in regulating endothelial function in pulmonary hypertension 3) the mechanisms underlying blood storage disease (in collaboration with Dr. John Roback, Pathology) and 4) the development novel rho kinase inhibitors for the treatment of pulmonary hypertension (a collaboration with Anacor Pharmaceuticals). Models include wild type and knockout or transgenic rodent models. Models may be challenged with a high fat diet to study diabetes or exposed to chronic hypoxia as a stimulus for the development of pulmonary hypertension. Approaches include everything from whole animal physiology to understand the effects of these models on blood pressure or pulmonary hypertension, to isolated tissue studies examining vascular contractility, to cellular preparations to examine biochemistry.

Recent research projects with mentees:

• Porter KM, Walp ER, Elms SC, Raynor R, Mitchell PO, Guidot DM, Sutliff RL. (2013). Human immunodeficiency virus-1 transgene expression increases pulmonary vascular resistance and exacerbates hypoxia-induced pulmonary hypertension development. Pulmonary Circulation; 2013; 3(1):58-67, PMCID: 3641741.

• Alexander JT, El-Ali AM, Newman JL, Karatela S, Predmore BL, Lefer DJ, Sutliff RL, Roback JD. Red blood cells stored for increasing periods produce progressive impairments in nitric oxide-mediated vasodilation. 2013; Transfusion; 53(11):2619-28. PMCID: 4140194.

• Kang BY, Park KK, Kleinhenz JM, Murphy TC, Green DE, Bijli KM, Yeligar SM, Carthan KA, Searles CD, Sutliff RL, Hart CM. PPARgamma Activation Reduces Hypoxia-induced Endothelin-1 Expression through Upregulation of miR-98. Am J Respir Cell Mol Biol. 2015.

• Adesina SE, Kang BY, Bijli KM, Ma J, Cheng J, Murphy T, Michael Hart C, Sutliff RL. Targeting mitochondrial reactive oxygen species to modulate hypoxia-induced pulmonary hypertension. Free Radic Biol Med. 2015.

Other recent manuscripts:

• Green DE, Murphy TC, Kang BY, Kleinhenz JM, Szyndralewiez C, Page P, Sutliff RL, Hart CM. The Nox4 inhibitor GKT137831 attenuates hypoxia-induced pulmonary vascular cell proliferation. Am J Respir Cell Mol Biol. 2012; 47(5):718-26. PMCID: 3547100.

• Sutliff RL, Hilenski LL, Amanso AM, Parastatidis I, Dikalova AE, Hansen L, Datla SR, Long JS, El-Ali AM, Joseph G, Gleason RL, Jr., Taylor WR, Hart CM, Griendling KK, Lassegue B. Polymerase Delta Interacting Protein 2 Sustains Vascular Structure and Function. Arterioscler Thromb Vasc Biol; 2013; 33(9):2154-61. PMCID: 3837414.

• Bijli KM, Kleinhenz JM, Murphy TC, Kang BY, Adesina SE, Sutliff RL, Hart CM. Peroxisome proliferator-activated receptor gamma depletion stimulates Nox4 expression and human pulmonary artery smooth muscle cell proliferation. Free Radic Biol Med. 2015;80:111-20

Aaron W. Trammell, MD Assistant Professor of Medicine Division of Pulmonary, Allergy, Critical Care & Sleep Medicine

I joined the Emory University faculty in 2015. Prior to coming to Emory, I completed internship and residency in Internal Medicine and fellowship in Pulmonary and Critical Care Medicine at Vanderbilt University, finishing in 2014. For one year between fellowship and joining the Emory faculty, I worked with a well-known pulmonary vascular disease clinician

and expert in clinical trials at Baylor College of Medicine in Houston, TX.

My clinical focus is caring for patients with various forms of pulmonary vascular disease including pulmonary arterial hypertension, a disease which bridges the fields of cardiology and pulmonology. My patient care activities are at The Emory Clinic and Emory University Hospital. As a fellow, my mentored research project involved the study of interactions of metabolism and pulmonary vascular disease development utilizing rodent and cell models with a focus on molecular biology. With these and other projects, I”ve had the chance to organize and present research at local and international meetings, and write case reports, reviews and book

chapters for publication. Through these, I have cultivated an inquisitive spirit and continue to build my skills of asking and answering important questions. At present and going forward, I plan a more clinical and translational research focus. Specifically, I hope to use next generation sequencing and -omics technologies to shed light on the mechanisms underlying clinically recognized differences in how patients with pulmonary arterial hypertension respond to available therapy.

In addition to caring for patients with pulmonary hypertension and striving to advance understanding of pulmonary vascular disease, I greatly enjoy working with learners of all levels “ and this allows me to be an active ongoing learner myself! As a junior faculty member, I am fortunate to be involved in both clinical and didactic teaching. In addition to my clinical service, I give part of the pulmonary module for medical students.

My pursuit of utilizing -omics technologies for pulmonary vascular disease development is in its early stages. For currently interested students, residents and fellows, I have several clinical research pursuits that involve utilizing existing data or electronic records systems to define how pulmonary hypertension is recognized and treated at Emory and the Atlanta VA. Beyond my existing ideas, I am always willing to help develop a trainee”s research interests, especially those exploring a topic related to pulmonary vascular disease.

Recent manuscripts and abstracts for which I had significant involvement:

• Trammell AW, Pugh ME, Newman JH, Hemnes AR, Robbins IM. Use of pulmonary arterial hypertension”approved therapy in the treatment of non”group 1 pulmonary hypertension at US referral centers. Pulmonary circulation 2015; 5: 356-363.

• Ruiz-Flores L, Nachiappan AC, Trammell AW, Misra A, Frigini LA, Lenge de Rosen VV. Pulmonary Hypertension: Review of Imaging, Prognostic Indicators, and Management. American Roentgen Ray Society 2015 Annual Meeting. Toronto, Canada; 2015.

• Hemnes AR, Trammell AW, Archer SL, Rich S, Yu C, Nian H, Penner N, Funke M, Wheeler L, Robbins IM, Austin ED, Newman JH, West J. Peripheral blood signature of vasodilator-responsive pulmonary arterial hypertension. Circulation 2015; 131: 401-409.

• Chen X, Talati M, Fessel JP, Hemnes AR, Gladson S, French J, Shay S, Trammell A, Phillips JA, Hamid R, Cogan JD, Dawson EP, Womble KE, Hedges LK, Martinez EG, Wheeler LA, Majka SJ, Loyd JE, West J, Austin ED. The Estrogen Metabolite 16alphaOHE Exacerbates BMPR2-Associated PAH Through miR-29-Mediated Modulation of Cellular Metabolism. Circulation 2015.

• Al-Naamani N, Trammell AW, Safdar Z. Circulating Biomarkers in Pulmonary Arterial Hypertension. Advances in Pulmonary Hypertension 2015; 14: 21-27.

• Trammell AW, Penner N, Fessel JP, Niswender KD, Newman JH, West JD, Hemnes AR. Hyperinsulinemia Promotes Pulmonary Hypertension Development In Mice. Am J Respir Crit Care Med 2014: A2620-A2620.

• Pugh ME, Hemnes AR, Trammell A, Newman JH, Robbins IM. Variability in hemodynamic evaluation of pulmonary hypertension at large referral centers. Pulmonary circulation 2014; 4: 679-684.

• Hemnes AR, Brittain EL, Trammell AW, Fessel JP, Austin ED, Penner N, Maynard KB, Gleaves L, Talati M, Absi T, Disalvo T, West J. Evidence for right ventricular lipotoxicity in heritable pulmonary arterial hypertension. Am J Respir Crit Care Med 2014; 189: 325-334.

• Trammell A, Talati M, Brittain E, Penner N, Gladson S, Blackwell T, Hemnes A. BMPR2 Mutation Results In Impaired GLUT4 Trafficking. Am J Respir Crit Care Med 2013: A1735-A1735.

• Hemnes AR, Trammell AW, Newman J, Robbins I, Penner N, Fox K, Wheeler L, Austin ED, Archer S, Rich S, West J. Gene expression patterns may differentiate vasodilator-responsive pulmonary arterial hypertension from non-responsive pulmonary arterial hypertension. 5th World Symposium on Pulmonary Hypertension (WSPH) 2013. Nice, France; 2013.

Cherry Wongtrakool, MD Assistant Professor of Medicine Associate Program Director, Pulmonary and Critical Care Medicine Fellowship Staff Physician, Atlanta VA Medical Center

My research interests span the intersection between tobacco/nicotine use and lung physiology and disease. I studied lung development using animal and cell culture models prior to arriving at Emory, particularly the importance of

retinoic acid signaling in the differentiation and maturation of lung cells. Upon arriving at Emory, I began studying how prenatal nicotine exposure affects lung development since maternal smoking is a significant risk factor for the development of asthma. My publications demonstrate that prenatal nicotine exposure increases branching morphogenesis, the developmental program responsible for forming the conducting airways in the fetal lung. This disruption in normal development leads to an increased number of small airways, increased airway remodeling and increased airway hyperresponsiveness. These findings may partly explain why offspring of maternal smokers are more likely to develop asthma. In 2009, I moved my research program to the VA and began studying how chronic nicotine exposure increases airway hyperresponsiveness using animal and human cell culture models from asthmatic patients. Currently, my research focuses on the mechanisms through which chronic nicotine exposure stimulates nerve growth factor, a neurotrophin, to promote airway hyperresponsiveness and whether asthmatics have an accentuated response to nicotine exposure. I have also been involved in clinical studies. I was a site principal investigator for the Examinations of HIV Associated Lung Emphysema study led by Kristina Crothers at University of Washington. Although the study is no longer enrolling patients, the study is still open for data analysis. I am also a co-principal investigator for industry sponsored studies at the VA. The most recent study is whether benralizumab, a monoclonal antibody directed against the IL-5 receptor, will reduce exacerbations in patients with moderate to severe COPD.

I also serve as the Associate Program Director for the Pulmonary/Critical Care Medicine fellowship. As such, I am very interested in fostering trainee scholarship. I currently am the Medical Director of the Pulmonary Function Laboratory and have a clinical interest in lung physiology and cardiopulmonary physiology with exercise and would be very willing to discuss clinical projects related to either of these. Outside of Emory, I am also involved in the American Federation for Medical Research as the Southern Section Chair this year planning the 2016 Southern Regional Meeting in New Orleans. I have also been involved in the American Thoracic Society as a Planning Committee Member and a Program Committee Member for RCMB.

Recent research projects with mentees:

• Carolyn McCabe (Emory undergraduate student, currently in graduate school at University of Michigan): “Chronic Nicotine Exposure Decreases LC3 Associated Phagocytosis”

• Sierra Gross, MD (postgraduate, currently in Family Medicine residency in Nevada) • Haixia Qin MD/PhD(Morehouse Internal Medicine Resident, currently in practice in California): "Into Thin Air-Air Embolism after

CT Guided Transthoracic Needle Biopsy"-ACP National Poster Finalist • Selected publications: • Wongtrakool C, Roman J. Tobacco smoke exposure, nicotine and the embryologic origins of asthma. Current Respiratory

Medicine Reviews. 2009 May; 5(2): 96-104. • Ramirez A, Wongtrakool C, Welch T, Steinmeyer A, Zugel U, Roman J. Vitamin D inhibition of pro-fibrotic effects of transforming

growth factor b in lung fibroblasts and epithelial cells. J of Steroid Biochem Mol Biol. 2010 Feb 15;118(3):142-150. PMCID: 2821704

• Wongtrakool C, Wang N, Grooms K, Roser-Page S, Rivera HN, Hyde DM, Roman J, Spindel ER. Prenatal nicotine exposure impairs offspring pulmonary function through altered geometry mediated by “7 nicotinic acetylcholine receptors. Am J Resp Cell Mol Biol, 2012 May;46(5):695-702.

• Wongtrakool C, Grooms K, Ping XD, Brown LA, Roman J, Gauthier TG. In utero nicotine exposure promotes alternative activation of alveolar macrophages. Pediatric Research, 2012 Aug;72(2):147-53.

• Crothers K, McGinnis K, Kleerup E, Wongtrakool C, SooHoo G, Kim J, Sharafkhaneh A, Huang L, Luo Z, Thompson B, Diaz P, Kirk GD, Rom W, Detels R, Kingsley L, Morris A. HIV Infection is associated with reduced pulmonary diffusing capacity. J AIDS, 2013 Nov 1;64(3):271-8.

• Wongtrakool C, Grooms K, Bijli K, Crothers K, Fitzpatrick AM, Hart CM. Nicotine stimulates nerve growth factor in lung fibroblasts through an NF”B dependent mechanism. PLoS One, 2014 Oct 9(10): e109602.

• Attia E, Akgun KM, Wongtrakool C, Goetz MB, Rodriguez-Barrada MC, Rimland D, Brown ST, Soo Hoo GW, Kim J, Lee PJ, Schnapp LM, Sharafkhaneh A; Justice A, Crothers K. Increased risk of radiographic emphysema in HIV is associated with elevated soluble CD14 and nadir CD4. CHEST, 2014 Dec 1;146(6):1543-53.

Samantha Yeligar, MS, PhD Assistant Professor of Medicine

I joined Emory University’s Alcohol and Lung Biology Center as a postdoctoral fellow in 2009. I investigated the role of NADPH oxidases and TGFβ in ethanol-induced oxidative stress and alveolar macrophage dysfunction, leading to alcoholics’ increased susceptibility to respiratory infections. In 2011, I received an F32 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) to study the effect of peroxisome proliferator activated receptor (PPAR)g

ligands on alcohol-induced alveolar macrophage dysfunction. In January of 2013, Dr. Yeligar joined the faculty as an Associate in Medicine, where my F32 served as a natural extension to an American Heart Association National Scientist Development Grant in 2012 to study the effect of PPARg ligands on alcohol-induced alveolar macrophage oxidative stress by modulating microRNA expression.

In September of 2013, I obtained a K99/R00 Pathway to Independence Award from the NIAAA to continue my studies on the role of microRNAs in modulating alcohol-induced alveolar macrophage oxidative stress and dysfunction. The novel treatment strategies I have studied to mitigate the detrimental effects of chronic alcohol ingestion on alveolar macrophage function have included S-adenosylmethionine, the critical antioxidant glutathione, and PPARg ligands rosiglitazone and pioglitazone. In 2015, I was promoted to Assistant Professor of Medicine. My benchwork research focuses have developed into translational projects and ongoing collaborations with Dr. Ashish Mehta and Dr. Sushma Cribbs. My aim is to translate my studies into human therapeutic strategies in improving lung immunity in subjects with a history of alcohol use disorders (Dr. Mehta) and subjects with HIV positive status (Dr. Cribbs). My main research focus is to elucidate the molecular mechanisms contributing to alveolar macrophage oxidative stress and phagocytic dysfunction in various pathologies and to examine novel therapeutic strategies that can be translated into clinical studies to improve lung immunity.

Recent Relevant Publications

• Morris NL, Yeligar SM. (2018) Role of HIF-1α in Alcohol-Mediated Multiple Organ Dysfunction. Biomolecules; 8(4). PMCID: PMC6316086.

• Grunwell JR, Yeligar SM, Stephenson S, Ping XD, Gauthier TW, Fitzpatrick AM, Brown LAS. (2018)

• TGF-β1 Suppresses the Type I IFN Response and Induces Mitochondrial Dysfunction in Alveolar Macrophages. Journal of Immunology; 200(6):2115-2128.

• Yeligar SM, Kang BY, Bijli KM, Kleinhenz JM, Murphy TC, Torres G, San Martin A, Sutliff RL, Hart CM. (2018) PPARγ Regulates Mitochondrial Structure and Function and Human Pulmonary Artery Smooth Muscle Cell Proliferation. American Journal of Respiratory Cell and Molecular Biology; 58(5):648-657. PMID: 29182484.

• Yeligar SM, Ward JM, Harris FL, Brown LAS, Guidot DM, Cribbs SK. (2017) Dysregulation of Alveolar Macrophage PPARγ, NADPH Oxidases, and TGFβ1 in Otherwise Healthy HIV-Infected Individuals. AIDS Research and Human Retroviruses; 33(10):1018-1026. PMCID: PMC5650722.

• Yeligar SM, Chen MM, Kovacs EJ, Sisson JH, Burnham EL, Brown LA. (2016) Alcohol and lung injury and immunity. Alcohol; 55:51-59. PMID: 27788778.

• Yeligar SM, Mehta AJ, Harris FL, Brown LA, Hart CM. (2016) Peroxisome Proliferator-Activated Receptor γ Regulates Chronic Alcohol-Induced Alveolar Macrophage Dysfunction. American Journal of Respiratory Cell and Molecular Biology; 55(1):35-46. PMID: 26677910.

• Kang BY, Park KK, Kleinhenz JM, Murphy TC, Green DE, Bijli KM, Yeligar SM, Carthan KA, Searles CD, Sutliff RL, Hart CM. Peroxisome Proliferator-Activated Receptor γ and microRNA 98 in Hypoxia-Induced Endothelin-1 Signaling. American Journal of Respiratory Cell and Molecular Biology; 54(1):136-46. PMID: 26098770.

• Yeligar SM, Harris FL, Hart CM, Brown LAS. (2014) Glutathione attenuates ethanol-induced alveolar macrophage oxidative stress and dysfunction by downregulating NADPH oxidases. American Journal of Physiology: Lung Cellular and Molecular Physiology; 306(5): L429-41. PMID: 24441868.

• Mehta AJ, Yeligar SM, Elon L, Brown LA, Guidot DM. (2013) Alcoholism causes alveolar macrophage zinc deficiency and immune dysfunction. American Journal of Respiratory and Critical Care Medicine; 188(6):716-23. PMID: 23805851.

• Liang Y, Yeligar SM, Brown LA. (2012) Chronic-alcohol-abuse-induced oxidative stress in the development of acute respiratory distress syndrome. The Scientific World Journal; 2012:740308. PMCID: PMC3543796.

• Liang Y, Yeligar SM, Brown LA. (2012) Exhaled breath condensate: a promising source for biomarkers of lung disease. The Scientific World Journal; 2012:217518. PMCID: PMC3539342.

• Yeligar SM, Harris FL, Hart CM, Brown LAS. (2012) Ethanol induces oxidative stress in alveolar macrophages via upregulation of NADPH oxidases. Journal of Immunology; 188(8): 3648-57. PMCID: PMC3324596.