EC – JPIAMR Strategic Interactions

EC-JPIAMR Strategic Interactions

• AMR strategy – not JPI strategy

• Antimicrobial resistance is a global societal challenge that must be met by strategies for both research and policy development

• AMR must be seen in a One Health perspective and thus requires strategies for research and policy development in drug development, human clinical medicine, animal health and the environment

• International - EU - National

2010 JPIAMR proposed by Sweden and Italy

2011 EC Action plan against the rising threats from Antimicrobial Resistance

2012 EC CSA JPIAMR

2013 JPIAMR Strategic Research Agenda

2014 IMI2 Strategic Research Agenda

2012 IMI1 Call #6 on AMR

2015 EC ERA-Net Cofund JPI-EC-AMR

2017 EC CSA EXEDRA

2016 Joint AMR workshop by JPIAMR, EC, IMI, and NIH

2013 IMI1 Call #11 on AMR

2012 IMI1 Call 8 on AMR

2013 IMI1 Call #9 on AMR

2015 WHO Global Action Plan on AMR

2018 JPIAMR Strategic Research & Innovation Agenda

2017 EC A European One Health Action Plan against Antimicrobial Resistance (AMR)

2014 JPIAMR Call 1

2015 JPIAMR Call 2

2016 JPIAMR Call 3/4

2017 JPIAMR Call 5

2018 JPIAMR Call 6/7/8

2016 UN General Assembly on AMR

2017 EC Joint Action EU-JAMRAI

2017 G20 & G7 Priority

JPIAMR 26 Members Countries

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JPIAMR Governance Structure

STEERING COMMITTEE

WG2 Govern

ance

SCIENTIFIC ADVISORY BOARD

WG3 Globalis

ation

WG5/6 Research

Alignment

WG4 Policy

Ailgnment

SECRETARIAT

MANAGEMENT BOARD

NATIONAL EXPERT PANELS

Core Call Steering Group

WG7 Industry relation

s

WG1 Evaluati

on

Call X Steering Group

NATIONAL POLICY GROUPS

EC Action plan against the rising threats from Antimicrobial Resistance 2011

Action no 11 Reinforce and co-ordinate research efforts, in particular: … - Support the launch of a Joint Programming

Initiative aimed at coordinating national research activities related to AMR

EC CSA JPIAMR 2012-2015

Objectives: • Organisation – Communication Platform • Mapping of research activities • Strategic Research Agenda • Implementation Plan • Industry Engagement • Evaluation Framework

JPIAMR

Strategic Research Agenda

6 Research Pillars

• Therapeutics - new drugs, vaccines, alternatives, and

incentives to bring drugs to market.

• Diagnostics - new, better, faster

• Surveillance - new standards and methods for

surveillance of drug resistance in humans, animals, and

the environment

• Transmission - emergence and selection mechanisms for

drug resistance

• Environment - role of the environment for the spread of

drug resistance

• Intervention -evidence base for prevention and infection

control measures

EC ERA-Net Cofund JPI-EC-AMR 2015-2020

Objectives: • Cofunded OneHealth call on Transmission

of AMR between humans, animals, and the environment

• Additional calls • Industry Engagement

EC CSA EXEDRA 2017-2020

Objectives: • Sustainability • Policy alignment • Research alignment

• Strategic Research and Innovation Agenda

• Virtual Research Institute • Mapping research activities and

construction of database

Therapeutics 29%

Diagnostics 0%

Surveillance 4%

Transmission 49%

Environment 9%

Interventions 9%

RESEARCH PROJECTS

Therapeutics 27%

Diagnostics 14%

Surveillance 27%

Transmission 14%

Environment 9%

Interventions 9%

NETWORKS/WORKING GROUPS

€

A global AMR scientific platform

for scientific interaction and

research capacity to:

Jointly address big research

questions/projects

Facilitate research and training on

AMR

(knowledge, expertise and

funding)

Stimulate networks from

currently independent

research communities in a

One Health approach

Improve the way resources are

shared and used between AMR stakeholders

EC A European One Health Action Plan against Antimicrobial Resistance (AMR)

2017

3. BOOSTING RESEARCH, DEVELOPMENT AND INNOVATION ON AMR …The proposed AMR research strategy covers the full One Health spectrum, addressing human and animal health as well as the role of the environment. It takes into account the priorities set out in the WHO Global Action Plan on AMR, the JPIAMR and national action plans. …

G7 Health Minister Meeting Milan Nov. 5-6

AMR in focus at G 7 Health Ministers meeting in Milan

…Health Ministers expressed that they welcome the establishment of the Global AMR R&D Hub and call to ensure it becomes an effective platform to align and increase global investment in much needed R&D based on WHO recommendations, e.g. the Priority Pathogen List (PPL). They expressed support for the collaboration of the Global AMR R&D Hub with existing international networks and initiatives like the Interagency Coordination Group on AMR, the Global Antibiotic Research & Development Partnership (GARDP), CARB-X and the Joint Programming Initiative on AMR (JPIAMR). https://www.jpiamr.eu/amr-in-focus-at-g-7-health-ministers-meeting-in-milan/

ANTIBIOTIC R&D FUNDING INTERNATIONAL INITIATIVES

Phase I

Phase II

Phase III

Basic Science Pre-clinical Mark

et

National Science Research Agencies

EC FP / European Research Council

ND4BB

US NIH / NIAID

EIB’s InnovFin

UK / China Global Innovation Fund

Recently Launched Existed Prior 2016

17

2010 JPIAMR proposed by Sweden and Italy

2011 EC Action plan against the rising threats from Antimicrobial Resistance

2012 EC CSA JPIAMR

2013 JPIAMR Strategic Research Agenda

2014 IMI2 Strategic Research Agenda

2012 IMI1 Call #6 on AMR

2015 EC ERA-Net Cofund JPI-EC-AMR

2017 EC CSA EXEDRA

2016 Joint AMR workshop by JPIAMR, EC, IMI, and NIH

2013 IMI1 Call #11 on AMR

2012 IMI1 Call 8 on AMR

2013 IMI1 Call #9 on AMR

2015 WHO Global Action Plan on AMR

2018 JPIAMR Strategic Research & Innovation Agenda

2017 EC A European One Health Action Plan against Antimicrobial Resistance (AMR)

2014 JPIAMR Call 1

2015 JPIAMR Call 2

2016 JPIAMR Call 3/4

2017 JPIAMR Call 5

2018 JPIAMR Call 6/7/8

2016 UN General Assembly on AMR

2017 EC Joint Action EU-JAMRAI

2017 G20 & G7 Priority

Key Success Factors for Strategic Interaction between EC and JPIAMR

• Coherent global political landscape

• Policy alignment on national level

• Policy alignment JPIAMR – EC

• True Partnership with frequent information exchange and strategic cooperation

• JPIAMR tool for international research collaboration and achieving goals of EC Global action plan.