7/24/2019 Drug Format

1/2

Gentamicin

DRUG ORDERMECHANISM OF

ACTIONINDICATIONS

CONTRAINDICATION

SADVERSE EFFECT

NURSING

RESPONSIBILTY

Generic Name:

Gentamicin

Brand name:

Garamycin

Classification:

antiinfective;

aminoglycoside

anti bioticification

Dosage and Route:

Neonate: IV/IM !"

mg/#g $%&'(

)cute *elvic

Inflammatory

Disease

)dult: IV/IM

mg/#g follo+ed by

%!" mg/#g $,(

Broad-s.ectrum

aminoglycoside

antibioticderived from

Micromonos.or

a .ur.urea!

)ction is usually

bacteriocidal!

*arenteral use

restricted to

treatment of

serious infectionsof GI res.iratory

and urinary tracts

CN0 bone s#in

and soft tissue

1including burns2

+(en ot(er less

to3ic antimicrobial

agents are

ineffective or are

contraindicated!

4as been used incombination +it(

ot(er antibiotics!

)lso used

to.ically for

.rimary and

secondary s#in

infections and for

su.erficial

infections of

e3ternal eye and

its adne3a!

4istory of

(y.ersensitivity to

or to3ic reaction

+it( anyaminoglycoside

antibiotic! 0afe use

during .regnancy

1category C2 or

lactation is not

establis(ed

0.ecial 0enses:

5toto3icity 1vestibular

disturbances im.aired

(earing2 o.tic

neuritis! CN0:

neuromuscular

bloc#ade: s#eletal

muscle +ea#ness

a.nea res.iratory

.aralysis 1(ig( doses2;

arac(noiditis

1intrat(ecal use2! CV:

(y.otension or

(y.ertension! GI:

Nausea vomiting

transient increase in)06 )76 and serum

7D4 and bilirubin;

(e.atomegaly

s.lenomegaly!

4ematologic:

Increased or

decreased reticulocyte

counts;

granulocyto.enia

t(rombocyto.enia

1fever bleeding

tendency2t(rombocyto.enic

.ur.ura anemia!

.

.7ab tests: *erform

C80 and renal

function .rior to

first dose and

.eriodically during

t(era.y; t(era.y

may begin .ending

test results!

! Re.eat C80 if

im.rovement does

not occur in 9&" d;

reevaluate t(era.y!

Note: Dosages are

generally adustedto maintain .ea#

serum gentamicin

concentrations of

'& % g/m7 and

troug(

concentrations of

%& g/m7! *ea#

concentrations

above % g/m7 and

troug(

concentrations

above g/m7 are

associated +it(

to3icity!

7/24/2019 Drug Format

2/2

Gentamicin