7/24/2019 Drug Format
1/2
Gentamicin
DRUG ORDERMECHANISM OF
ACTIONINDICATIONS
CONTRAINDICATION
SADVERSE EFFECT
NURSING
RESPONSIBILTY
Generic Name:
Gentamicin
Brand name:
Garamycin
Classification:
antiinfective;
aminoglycoside
anti bioticification
Dosage and Route:
Neonate: IV/IM !"
mg/#g $%&'(
)cute *elvic
Inflammatory
Disease
)dult: IV/IM
mg/#g follo+ed by
%!" mg/#g $,(
Broad-s.ectrum
aminoglycoside
antibioticderived from
Micromonos.or
a .ur.urea!
)ction is usually
bacteriocidal!
*arenteral use
restricted to
treatment of
serious infectionsof GI res.iratory
and urinary tracts
CN0 bone s#in
and soft tissue
1including burns2
+(en ot(er less
to3ic antimicrobial
agents are
ineffective or are
contraindicated!
4as been used incombination +it(
ot(er antibiotics!
)lso used
to.ically for
.rimary and
secondary s#in
infections and for
su.erficial
infections of
e3ternal eye and
its adne3a!
4istory of
(y.ersensitivity to
or to3ic reaction
+it( anyaminoglycoside
antibiotic! 0afe use
during .regnancy
1category C2 or
lactation is not
establis(ed
0.ecial 0enses:
5toto3icity 1vestibular
disturbances im.aired
(earing2 o.tic
neuritis! CN0:
neuromuscular
bloc#ade: s#eletal
muscle +ea#ness
a.nea res.iratory
.aralysis 1(ig( doses2;
arac(noiditis
1intrat(ecal use2! CV:
(y.otension or
(y.ertension! GI:
Nausea vomiting
transient increase in)06 )76 and serum
7D4 and bilirubin;
(e.atomegaly
s.lenomegaly!
4ematologic:
Increased or
decreased reticulocyte
counts;
granulocyto.enia
t(rombocyto.enia
1fever bleeding
tendency2t(rombocyto.enic
.ur.ura anemia!
.
.7ab tests: *erform
C80 and renal
function .rior to
first dose and
.eriodically during
t(era.y; t(era.y
may begin .ending
test results!
! Re.eat C80 if
im.rovement does
not occur in 9&" d;
reevaluate t(era.y!
Note: Dosages are
generally adustedto maintain .ea#
serum gentamicin
concentrations of
'& % g/m7 and
troug(
concentrations of
%& g/m7! *ea#
concentrations
above % g/m7 and
troug(
concentrations
above g/m7 are
associated +it(
to3icity!
7/24/2019 Drug Format
2/2
Gentamicin