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Colleagues, As the summer is coming to close, I would like to highlight a number of departmental initiatives that will begin shortly. We are continuing to expand our faculty development programs under the very capable leadership of Dr. Emelia Benjamin and Robina Bhasin. We will continue to experiment with new approaches to leadership development for several different groups of faculty, especially including under-represented minority faculty. The goals of these programs are to enhance the skills of our faculty in leading and managing, to successfully achieve meaningful personal and professional goals, and to create strong learning communities within the department. We anticipate many “lessons learned” from these efforts that will inform our future initiatives. I hope you will consider joining one of these faculty development initiatives. We will also be intensifying our efforts to increase the joy of clinical practice among all of our clinicians. The demands for higher productivity, more documentation, and complex billing practices, in an environment with inconsistent practice infrastructure have contributed to decreased resiliency in our profession, and may be adversely affecting the patient experience and clinical quality. We will be working diligently in partnership with BMC leadership to address these issues. Dr. Christine Sinsky, a national leader in this field, will be the Ingelfinger Visiting Professor at Evans Days October 16 and 17, 2014. We look forward to several conversations with Dr. Sinsky regarding best practices in this area. Finally, we will be renewing our departmental strategic plan over the next few months. I am hoping that all faculty will provide input into our strategic priorities, and help us align those priorities with local and national needs and opportunities, as well as those of BMC and BUSM. We look forward to your participation and feedback regarding each of these exciting initiatives! Meanwhile, I hope you enjoy the remaining days of summer!
David Coleman, M.D.
Message from the Chairman
Boston Medical Center/ Boston University School of Medicine
Department of Medicine Newsletter
August 2014 Department of Medicine Newsletter
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Clinical Pilot Grant Award Winners
Department of Medicine Newsletter
Page 2
Karen Lasser, MD, MPH Natasha Hochberg, MD, MPH
Sabrina Assoumou, MD, MPH Christine Liu, MD, MS
Gerald Denis, PhD
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Department of Medicine Newsletter
Basic Science Pilot Grant Winners—Part 1
Manish Sagar, MD, Associate Professor, Infec�ous Diseases “Role of CD1a
vaginal epithelial cells in HIV-1 heterosexual acquisi�on”
Isabel Dominguez, PhD, Assistant Professor, Hematology/Oncology
“Endocardial Role of CK2a in cardiac Trabecular forma�on”
Tamar Aprahamian, PhD, Assistant Professor, Nephrology and Francesca
Seta, PhD, Assistant Professor, Vascular Biology “Paracrine func�ons of peri-
aor�c VEGF-A in arterial s�ffness and hypertension”
Manish Sagar, MD Isabel Dominguez, PhD
Tamar Aprahamian, PhD Francesca Seta, PhD
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Basic Science Pilot Grant Winners—Part 2
Jude Deeney, PhD, Assistant Professor, Gastroenterology “Inhibi�on
of bromodomain protein 2 as a novel epigene�c therapy for type 2
diabetes”
Stefano Mon�, PhD, Associate Professor, Computa�onal Biomedicine
“Role of GPS2 in driving therapeu�cally relevant metabolic rewiring in
cancer”
Jay Mizgerd, PhD, Professor, Pulmonary “PD-L2 and heterotypic
immunity against bacterial pneumonia”
Hans Dooms, PhD, Assistant Professor, Rheumatology “Dysregulated
cellular metabolism predisposes to Type 1 diabetes”
Hans Dooms, PhD Jay Mizgerd, Sc.D.
Stefano Monti, Ph.D Jude Deeney, Phd
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Page 5
Department of Medicine Newsletter
DOM Administration Awards
I have worked with Laura since 2007. When I was new in my role in Geriatrics she took the time to help me acclimate to my new position and was always open to offering guidance. She is a stable force in the Section of Geriatrics and is one that many other administrators look to for guidance. She has exemplary work ethic and customer service. I consider her a role model in this respect and am proud to have her as a colleague who represents BMC. I have transitioned from Geriatrics to the Residency Program Office where I still find myself reaching out to Laura from time-to-time for assistance in my new role. She has offered to help mentor me as I try to gain a better understanding of the budgeting and finance processes within BMC/Evans/DOM. This is an area which does not come naturally to me, so it helps tremendously to have someone I can go to when I am faced with various challenges or sometimes just a simple question. This willingness to take the time to offer her assistance to another administrator outside of her section is certainly beyond the scope of her position which is why I feel that Laura is deserving of this award. In a nutshell, she has a great depth of institutional knowledge which she willing shares with others and is without a doubt a team player with a high standard of work ethic and service excellence.
Eva Greenwood, MBA, Laura Anastasi and Laurie Dubois
Jacqui is an outstanding administrative assistant. When the Arthritis Center Administrative secretary was on leave Jacqui stepped in and performed the secretary’s duties in addition to her own for several months. Then when the two financial administrative assistants in the Arthritis Center left within a few weeks of each other, Jacqui stepped in again and has been assisting us with patient reimbursements for clinical study participation, ordering supplies, and other duties as necessary. She even trained an administrative secretary from the Renal section in the use of BU Works so that we could get some invoices paid for a trial that is run jointly with the Renal section. No matter what the situation, Jacqui is always available to help and is always pleasant and professional. Jacqui has gone above and beyond her job description on several occasions and has carried the workload of two employees on two occasions without complaint. Whenever there is an issue to be resolved, Jacqui picks up the phone, finds the appropriate person to communicate with, and provides you with a resolution. Jacqui is always in the office and when she tells you she’ll get something done, it is done promptly and correctly. She is organized and has planned several successful events for both the Arthritis Center and the Vasculitis Center. The Arthritis Center and Vasculitis Center owe Jacqui a great debt of gratitude for all she has done and all she continues to do to keep the centers running smoothly. This award would be a wonderful way to show our appreciation of her sacrifice and commitment. I give Jacqueline Chapski my highest recommendation for the 2014 Administration Award.
Britte Beaudette-Zlatanova, Jacquie Chapski, Eva Greenwood, MBA
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Department of Medicine Newsletter
Recent Promotions
Paul Monach, MD, PhD was recently promoted to Associate Professor in the Section of Rheumatology.
Yazdani Basha Shaik-Dasthagirisaheb, MPhil, PhD was recently promoted to Research Assistant Professor in the Section of Infectious Diseases.
Dr. Sheilah Bernard has been asked to serve on the AAIM Resident to Fellow Interface Committee.
The resident to fellow interface committee is charged to develop programs and resources for faculty and staff responsible for preparing internal medicine residents for their transition from residency to fellowship training; and monitor issues related to the transition from residency to fellowship. Dr. Bernard will serve a 2 year term that will begin July 1, 2014.
Sheilah Bernard, MD
Sandra Ordonez
Sandra Ordonez, Program Coordinator for the Internal Medicine Residency Program Office, has been elected to serve on the AAIM Diversity and Inclusion Committee. The Diversity and Inclusion Committee is charged to investigate and recommend means to ensure academic medicine represents the diversity of the US population and supports women and underrepresented minorities; provides strategies for departments of internal medicine to build diversity programs and tools to self-assess diversity issues; and administering the AAIM Diversity Award.
Congratulations!
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Thomson Reuters answers this question, as it has in the past, by analyzing data using its Web of Science and InCities platforms to determine which researchers have produced work that is most frequently acknowledged by peers. These highly cited researchers were determined by analyzing at citation data over the last 11 years to identify those who published the highest impact work (2002-2012 and 2012-
2013). These individuals are influencing the future direction of their fields, and of the world.
Thomson Reuters names the Worlds Most Scientific
Minds of 2014
Emelia Benjamin, MD, ScM
Vasan Ramachandran, MD, DM, FACC, FAHA
Michael Holick, MD, PhD
http://sciencewatch.com/sites/sw/files/sw-article/media/worlds-most-influential-scientific-minds-2014.pdf
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The Department of Medicine would like to offer a warm and hearty welcome to the intern class of 2014.
Here are a few interesting facts about the 2014 intern class: Eleven interns (20%) are graduates of our home institution. We have seven Alpha Omega Alpha (AOA) Society members, one Gold Humanism recipient and one Fulbright Scholar. 25% of the intern class holds an advanced degree. Prior to joining residency, members of the intern class have volunteered in Tanzania, Albania, rural India, Honduras, Haiti, and Guatemala, founded a local Burmese refugee organization, and worked in NGOs in Delhi and Lucknow. They are speakers of over 25 different languages including Amharic, Malayalam, Hungarian, and Greek (to name a few). We are proud to have 54 new ambassadors of BMC’s mission amongst us.
As the interns settle in, the Residency Program Office is gearing up for recruitment season 2015. Faculty please watch your inbox for information from Shannon Showalter ([email protected]) on this year’s interview dates and scheduling.
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The Section of General Internal Medicine has had a lot of good news in securing new
grant funding in 2014. Many of GIM units and research groups contributing to these
successes have brought in over $10 Million in new grant support this year.
The Clinical Addictions Research and Education (CARE) Unit established in 1991 and currently directed By Dan Alford, MD conducts research, educates health professionals, provides health care, and informs clinical and public health practice and policy to improve the lives of people with unhealthy alcohol and other drug use.
Jane Liebschutz, MD, MPH received a subcontract award with Butler Hospital (Brown University) of $1.13M from the National Institute on Drug Abuse (NIDA) to conduct a randomized controlled trial of a motivational interviewing intervention seeking to reduce sharing needles, re-using needles, and the number of bacterial skin infections among injection drug users during the year after they are discharged from the hospital.
Jeffrey Samet, MD, MA, MPH received a NIDA funded subcontract award with the University of British Columbia of $124,210 to help develop a one-year intensive addiction research fellowship training program involving hands-on interdisciplinary research experience for addiction medicine physicians, which takes advantage of an existing NIDA-funded platform of qualitative, epidemiology, clinical and basic science research. Dr. Samet will also advise on study implementation and data analysis for a study on the Impact of Heavy Alcohol Use on Pre-ART HIV Disease for a Uganda Alcohol – HIV Cohort with funding from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) in a subcontract with the University of California, San Francisco.
Christine Pace, MD, MSc, is leading a pilot program to integrate behavioral health services into Adult Primary Care. The funds will support Dr. Pace in her effort to expand and evaluate the behavioral health program within primary care at BMC. This includes screening for depression and unhealthy substance use; short term on-site psychotherapy and substance use counseling; depression care management; and on-site psychiatric consultation. This program is funded by Harvard Pilgrim Health Plan, totaling $83K.
The Health Care Disparities Research (HCDRU) Unit, established in 2008 and directed by Nancy Kressin, PhD, fosters the conduct of high quality research to understand and alleviate inequities in health care, and to ensure the provision of exceptional health care without exception. The Program is dedicated to understanding and addressing disparities in health and health care and to train a new generation of health care equity researchers.
Spotlight on General Internal Medicine
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Amresh Hanchate, PhD, who is a par t of the HCDRU Unit, secured $2.16M from the Nation-
al Institute on Minority Health and Health Disparities (NIMHD) for a grant to measure inpatient care access, quality and discharge outcomes among Hispanics nationally. His group will combine state inpatient discharge (SID) data along with census population data to obtain representative es-timates of inpatient care utilization for Hispanic adults and contrast them with those for non-
Hispanic Whites and non-Hispanic Blacks. Representative estimates of inpatient care utilization and their outcomes for Hispanics have never been presented; they will establish measurable target indicators, help set national priorities, and will provide a mechanism with which to judge the rela-tive impact of new policy initiatives for minorities by ethnicity and race.
The Women’s Health Unit (WHU), established in 1986 and directed by Tracy Battaglia, MD,
MPH, is an academic unit addressing all aspects of women’s health through clinical care, medical education, research, faculty development and community outreach. The WHU was particularly successful in 2014, receiving a total of $3.42M for Project SUPPORT (Socio-legal services for Underserved Populations thru Patient navigation to Optimize Resources during Treatment). Project SUPPORT is a 5-year randomized controlled trial to evaluate the effect of patient navigation enhanced with medical-legal advocacy on patient reported and clinical out-comes. Funded by both Patient-Centered Outcomes Research Institute (PCORI) and the American Cancer Society (ACS), Project SUPPORT intends to enroll 374 newly diagnosed cancer patients who will be randomized to receive Standard Patient Navigation services or Patient Navigation that is enhanced by support from the Medical Legal Partnership (MLP).
The General Internal Medicine Fellowship and Preventive Residency Program, was estab-lished in 1982 and is directed by Jane Liebschutz, MD, MPH; these programs train highly moti-vated primary care physicians to serve as educators and investigators, with a focus on topics rele-vant to medically underserved communities. The Program offers mentored training in clinical epi-demiology and health services research, medical education, public health, and prevention.
The Preventive Medicine Residency was awarded a 5 year, $2.38 million training grant from the Health Resources & Services Administration (HRSA). The overall goal of this grant is to create a 4 year combined residency training program in internal medicine and preventive medicine. By taking advantage of overlap between the two programs, trainees will be able to obtain full clinical training in internal medicine as well as a master’s degree at the School of Public Health, in depth research experience and practical experience in public health in 4 years instead of the usual 5 years required to complete the two programs. The vision of the program is to create a cadre of in-ternal medicine trained physicians who are equipped with research, leadership and public health skills to address the pressing health care issues of our time.
Additionally, Michael Paasche-Orlow, MD, MA, MPH, received $1.15M from the National Heart, Lung, and Blood Institute (NHLBI) for secondary analyses to investigate causal path-ways linking health literacy to health outcomes including intermediary chronic disease outcomes, quality of life, hospitalization and mortality. He and his team will also examine how health litera-cy serves as a mediator of racial and ethnic health disparities. Dr. Paasche-Orlow will also direct the 6th Health Literacy Annual Research Conference, with funding from AHRQ and NIMHD.
GIM continued….
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2014-2015 Faculty Development & Diversity Seminar Series
All seminars take place from 12-1pm in the Wilkins Board Room, unless otherwise noted.
Date Topic Facilitator
September 15, 2015 A Thirty Year Perspective of Life in Academic
Medicine Becky Silliman
September 23, 2014 Effectively Managing an Ineffective Employee Boris Lazic
October 20, 2014 An Introduction to Narrative Medicine: What it
is and how it works Tom Barber
October 27, 2014 (12-
1:30) Negotiating Skills and Conflict Management Karen Antman
October 28, 2014 The Art of Interviewing: Knowing your intern
applicant (and other ERAS tricks)
Sheilah Bernard Catherine Rich
December 2, 2014 Coaching in Medicine Jane Liebschutz
and Gail Gazelle
January 27, 2015 Understanding and effectively working with
introverts and extroverts
Becky Silliman and Nancy
February 2, 2015 Incorporating quality improvement in a busy
clinical schedule Karin Sloan
February 3, 2015 Microagressions in Academic Medicine Linda Barnes
February 9, 2015 Faculty Flexibility Emelia Benjamin and Robina
March 23, 2015 Staffing and Managing Your Lab Panel Isabel Dominguez, Barb Nikolajczyk and
Bill Cruikshank
March 2015 Foundation funding: Learning about what gets funded and using the resources of the
development offices
Sharon Levine, Tracy Battaglia, Chris Bonner and
Kirsten Hinsdale
April 2015 Industry Sponsored Research and Technology
Transfer for Researchers
Mike Pratt, Weining Lu and
Orian Shirihai
April 2015 How to create an education portfolio workshop Angela Jackson
May 11, 2015 Navigating the IRB for educational research Mary-Tara Roth
May 2015 Turning Education into Scholarship Kitt Shaffer and
Sharon Levine
June 1, 2015 CV Boot Camp Kitt Shaffer, David Coleman, David Salant,
Emelia Benjamin
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New BMC Grants May - July 2014
SECTION PI LAST NAME
PI FIRST
NAME PROJECT TITLE
PROJECT
TOTAL
COSTS
PROJECT
END DATE FUNDING AGENCY
Endocrinology, Diabetes and Nutrition Safer Joshua
A Pilot Program To Educate Physicians in Transgender Medicine $13,000 4/1/2014 Boston Foundation
Endocrinology, Diabetes and Nutrition Pearce
Eliza-
beth
Perchiorate and Thyroid Hormones In Pregnancy and Infants in Southern Cal-ifornia $27,254 6/1/2013
Univ of Cailfornia, Berkeley
Gastroenterology Corkey Barbara
Mitochondrial regulation of energy efficiency $922,782 4/1/2014 NIH-NIDDK
Gastroenterology Shirihai Orian
Mitochondrial regulation of energy efficiency $922,782 4/1/2014 NIH-NIDDK
General Internal Medicine Pace
Chris-
tine
Integrated Behavioral Health Services in an Aca-demic Safety-Net Hospital: A Pilot Program $82,739 4/7/2014
Harvard Pilgrim Health Care (HPHC)
Geriatrics O'Brien Eileen
Elders Living at Home Pro-gram's Aging Right in Com-munity Project $25,000 5/15/2014
Florence V. Burden Foundation
Infectious Dis-eases Ellner Jerrold
Training of Ugandans in Basic Research on TB and Emerging Infectious Diseas-es $861,058 3/12/2014 NIH-FIC
Infectious Dis-eases Lin Nina
Analysis of properties of HIV-1 subtype C envelope glycoprotein $250,809 4/30/2016 NIH-NIAID
Infectious Dis-eases Montano Monty
Biomarkers for Muscle Function and Aging in Chronic HIV Infection $3,615,573 5/31/2019 NIH-NIAID
Infectious Dis-eases Linas
Benja-
min
Simulation Modeling to Im-prove HIV/HCV Screening, Treatment & Care - Supple-ment $197,522 5/31/2016 NIH-NIDA
Nephrology Chitalia Vipul
Role of c-Cbi in Colon Can-cer $1,803,694 4/30/2019 NIH-NCI
Cardiology Ruberg
Freder-
ick
Cardiac Function as a Mechanism for Maladaptive Brain Aging $66,728 2/28/2015
Vanderbilt University Medical Center
Cardiology Sverdlov Aaron
Oxidative post-translational modification of mitochondri-al complex II in metabolic heart disease $110,200 6/30/2016 American Heart Assoc
13
SECTION
PI LAST
NAME
PI FIRST
NAME PROJECT TITLE
PROJECT TO-
TAL COSTS
PROJECT
END DATE FUNDING AGENCY
Endocrinology, Diabetes and Nutrition Lee
Mi-
Jeong
Defining the phenotypes of brite human adipocytes us-ing a systems biology ap-proach $31,433 5/31/2015
Trustees of Boston University
Endocrinology, Diabetes and Nutrition Ruderman Neil
Metabolism, Endocrinology & Obesity Training Grant $1,666,493 6/30/2019 NIH-NIDDK
Gastroenterology
Mostoslav-
sky
Gusta-
vo
Targeting Sequencing and Functional Evaluation of Mutations in Schizophrenia $14,573 4/30/2015
Northshore University Health System
Gastroenterology Roy Hemant
Nanocytological Fecal As-sessment to Personalize Colonoscopic Surveillance $92,146 8/31/2014 Nanocytomics, LLC.
Gastroenterology Roy Hemant
Polyethylene Glycol for ACF Reduction and Bi-omarker Modulation in Indi-viduals w CRC Risk(NWU06-8-01) $132,000 6/30/2014
Northwestern Universi-ty
General Internal Medicine Lasser Karen
Patient Navigation and Fi-nancial Incentives to Pro-mote Smoking Cessation $792,000 6/30/2018 American Cancer Soc
General Internal Medicine Shanahan
Chris-
topher
Optimizing Pain Control and Safety in Patients Pre-scribed Opiod after Day Surgery $49,960 6/30/2015
CareFusion Founda-tion
General Internal Medicine Weinstein Zoe
Next Generation Award for Adolescent Substance Use Prevention-Zoe Weinstein $25,000 6/30/2015
American Board of Addiction Medicine Foundation
Geriatrics Perls
Thom-
as
The Long Life Family Study: Boston Field Center $5,742,817 5/31/2019 NIH-NIA
Infectious Dis-eases Ellner Jerrold
Biomarkers and Mecha-nisms of Paucibacillary and Latent Tuberculosis $21,040,818 7/31/2021 NIH-NIAID
Infectious Dis-eases Henderson Andrew
Novel Compounds that tar-get HIV latency $487,941 6/30/2016 NIH-NIAID
Medical Infor-mation Systems Unit Quintiliani Lisa
Behavioral Cardiovascular Disease Prevention using Informatics $308,000 6/30/2018 American Heart Assoc
Nephrology Salant David
Alnylam Sponsored Re-search Agreement $91,605 5/31/2015
Alnylam Pharmaceuti-cals
Nephrology Shashar Moshe
Role of Uremic Solutes in Thrombosis $100,000 6/30/2015
American Society of Nephrology
14
PI Sec�on Award Title Sponsor
Project
End Date
Award
Amount
JACKSON H AN-
GELA
GEN INTERNAL MED
2014 MARGARET E. MA-HONEY FELLOWSHIP
THE NEW YORK ACAD-EMY OF MEDICINE
08/31/2014
4,500.00
MURPHY R
JOHN
INFECT DISEASE MED
NATIONAL EMERGING INFECTIOUS DISEASES LABORATORIES OPER-ATIONS
NIH/NATIONAL INSTI-TUTE OF ALLERGY & INFE
05/31/2016
13,568,838.0
0
NEOGI TUHINA
MED--CLIN EPI RES & TRAINUNIT
BISPHOSPHATE EF-FECTS IN KNEE OSTEO-ARTHRITIS
ARTHRITIS FOUNDA-TION
04/30/2016
100,000.00
FELSON T. DA-
VID
MED--CLIN EPI RES & TRAINUNIT
RUTH L. KIRSCHSTEIN (NRSA) INSTITUTIONAL RESEARCH TRAINING GRANT (T32)
NIH/NATIONAL INSTI-TUTE OF ARTHRITIS & MU
04/30/2019
219,849.00
TROJANOWSKA
MARIA
MED--RHEUMATOLOGY/ARTHRITIS
MOLECULAR MECHA-NISM OF VASCULOPA-THY AND FIBROSIS IN SCLERODERMA
NIH/NATIONAL INSTI-TUTE OF ARTHRITIS & MU
04/30/2019
360,140.00
JACKSON H AN-
GELA
GEN INTERNAL MED
2014 STUDENT SUM-MER FELLOWSHIP FOR LESLIE MANESS
THE ARNOLD P. GOLD FOUNDATION
09/18/2014
4,000.00
STEINBERG H
MARTIN
HEM/ONC MED
RESEARCH TRAINING IN BLOOD DISEASES AND RESOURCES
NIH/NATIONAL HEART, LUNG, AND BLOOD INST
05/31/2019
222,310.00
APRAHAMIAN R
TAMAR
NEPHROLOGY
THE ROLE OF RETI-NALDEHYDE AND ADI-POGENESIS IN THE PROGRESSION OF SYS-TEMIC LUPUS ERYTHE-MATOS
THE LUPUS FOUNDA-TION OF AMERICA, INC.
08/15/2014
4,000.00
BU Grants
15
PI Sec�on Award Title Sponsor
Project
End Date
Award
Amount
TAGNE JEAN-
BOSCO
PULMONARY EPI
CONTROL OF PROLIF-ERATION-RELATED GENES AND MIRS BY NKX2-1 IN LUNG DEVEL-OPMENT
NIH/NATIONAL HEART, LUNG, AND BLOOD INST
05/31/2019
134,379.00
FARBER W HAR-
RISON
PULMONARY EPI
A PROSPECTIVE, MUL-TICENTER, DOUBLE-
BLIND, RANDOMIZED, PLACEBO-
CONTROLLED, PARAL-LEL-GROUP, 12-WEEK STUDY TO EVALUATE THESAFETY AND TOL-ERABILITY OF MACITENTAN IN SUB-JECTS WITH COMBINED PRE- AND POST-CA
ACTELION CLINICAL OPERATIONS, INC.
06/10/2016
0.51
QUINTON J LEE PULMONARY EPI DISTINCT ROLES OF LIF AND OSM DURING PNEUMONIA
NIH/NATIONAL HEART, LUNG, AND BLOOD INST
06/30/2015
63,122.00
WILSON AN-
DREW
PULMONARY EPI A NEXT-GENERATION IN VITRO AATD CLINI-CAL TRIAL
ALPHA 1 FOUNDATION 06/30/2016
100,000.00
BU Grants continued
