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DermatitisDermatitisDermatitisDermatitis
• Definisi:Definisi:• Peradangan kulit (epidermis, dermis)
sebagai respons terhadap pengaruh faktorsebagai respons terhadap pengaruh faktor eksogen dan atau faktor endogen. Menimbulkan kelainan polimorfik (eritemaMenimbulkan kelainan polimorfik (eritema, edema, papul, vesikel, skuama, likenifikasi)likenifikasi)
EtiologiEtiologiEtiologiEtiologi
Faktor eksogen: bahan kimiafi ik (SUV)fisik (SUV)
Faktor endogen: Dermatitis Atopik
KlinisKlinisKlinisKlinis
Keluhan gatalKeluhan gatalKelainan kulit bergantung pada stadium• Akut : eritema edema vesikel/ bula erosiAkut : eritema, edema, vesikel/ bula, erosi,
eksudasi• Subakut: eritema ber ( ) eksudat kering krusta• Subakut: eritema ber (-), eksudat kering krusta• Kronis : lesi kering, skuama, papul, likenifikasi,
erosi ekskoriasierosi, ekskoriasi
Tatanama/KlasifikasiTatanama/KlasifikasiTatanama/KlasifikasiTatanama/Klasifikasi
• Belum seragamBelum seragam• Ada yg berdasarkan:
ti l i (DK D M dik t )etiologi (DK, D. Medikamentosa)morfologi (papulosa, eksfoliativa)bentuk (D. Nummularis)lokalisasi (D intertrigenous)lokalisasi (D. intertrigenous)
DERMATITIS
Eczema Contact Dermatitis
Non AllergicContactAllergic ContactNon AtopicAtopic Dermatitis
(Eczema / ContactDermatitisDermatitisDermatitis(Eczema /
Atopic Eczema)
DERMATITISDERMATITIS1. Nonspecific Eczemaous1. Nonspecific Eczemaous
DermatitisDermatitisDermatitisDermatitis2. Atopic Dermatitis2. Atopic Dermatitis3. Contact Dermatitis3. Contact Dermatitis4 Seborrheic Dermatitis4 Seborrheic Dermatitis4. Seborrheic Dermatitis4. Seborrheic Dermatitis5. Stasis Dermatitis5. Stasis Dermatitis6 Li h Si l Ch i6 Li h Si l Ch i6. Lichen Simplex Chronicus6. Lichen Simplex Chronicus
Histological DermatitisHistological DermatitisHistological DermatitisHistological Dermatitis
Histological: gIntercellular edema (spongiosis)inflammatory infiltrate in dermisy
- Acute dermatitis: erythema, edema, spongiosis causing vesicular
- Subacute dermatitis: less spongiosis, juicy papules
- Chronic dermatitis: thickened epidermis (lichenification)/acanthotic, slight spongiosis, scalling
The hallmarks of Eczematous The hallmarks of Eczematous D titiD titiDermatitisDermatitis
• 1 Marked pruritus1. Marked pruritus• 2. Indistinct border
3 E id l h b i l j i• 3. Epidermal changes by vesicles, juicy papules/lichenification
• 4. Localized/ diffuse• 5 Idiopathic/ cause by specific ethiology5. Idiopathic/ cause by specific ethiology
Regional DermatitisRegional DermatitisRegional DermatitisRegional Dermatitis• Ear Eczema• Eyelid dermatitis• Breast Eczema
H d E I it t h d d titi• Hand Eczema Irritant hand dermatitis• Vesicobullous Hand Eczema (Pompholyx, Dyshydrosis)• Chronic vesicobullous hand eczemaChronic vesicobullous hand eczema• Hyperkeratotic Dermatitis of the palms• Autosensitization Dermatitis• Xerotic Eczema• Nummular Eczema
Nummular eczemaNummular eczemaNummular eczemaNummular eczema
• Nummular dermatitisNummular dermatitis• Predominantly a disease of adulthood (50-
65 years) rare in infancy childhood65 years), rare in infancy, childhood• Man>Women• Characteristic: Oval patches with
crusted papulovesiclesLocalisation: Trunk
ExtremitiesExtremities
Nummular EczemaNummular EczemaNummular EczemaNummular Eczema• Also known as discoid eczema• A chronic disorder of unknown etiology• Papules and papulo vesicles cialescencePapules and papulo vesicles cialescence
to form nummular plazues with oozing, crust and scalecrust and scale
• Commone sites: upper extremities, dorsal hands in women lower extremities in manhands in women lower extremities in man
• Pathology acute, subacute, chronic eczema
Etiology and PathogenesisEtiology and PathogenesisEtiology and PathogenesisEtiology and Pathogenesis
• Pathog Is unknownPathog. Is unknown• Family history atopy (-)
H d ti f th ki i d d• Hydration of the skin is decreased• Role of infection• Role of invironmental allergen: HDM,
Cand
Clinical ManifestationClinical ManifestationClinical ManifestationClinical Manifestation
• Well demarcated coin-shape plaquesWell demarcated, coin shape plaques from coalescing papules and papulovesiclespapulovesicles
• Pinpoint oozing, crusted entire surfacePl 1 3 i i• Plaque 1-3 cm in size
• Surrounding skin is normal/ xerotic• Pruritus• Central resolution annular formCentral resolution annular form
Clinical ManifestationClinical ManifestationClinical ManifestationClinical Manifestation
• Chronic plaque are dry scaly and• Chronic plaque are dry, scaly and lichenifiedL b t t t t h t t b f l i• Laboratory test: patch test maybe seful in chronic recalcitrant– rule out
i d CDsuperimposed CD
Differential DiagnosisDifferential DiagnosisDifferential DiagnosisDifferential Diagnosis
Acute vesico papular dermatitis:Acute vesico papular dermatitis:Contact dermatitisInfections: Dermatophyte HS virusInfections: Dermatophyte, HS virus,
Varicella Zoster, BacteriaCh i i l d titiChronic vesico papular dermatitis:
Chronic CD, psoriasis, drug eruption,fungal infect
TherapyTherapyTherapyTherapy1. Corticosteroid:
- topically (under occlution)- injectable intralesional
sistemic- sistemic2. Calceneurin inhibitors: tacrolimus,
pimecrolimus3. Wide spread acute/ subacute eczematous:
prednisone/ triamcinolone 40 mg/i mwet dressing/bath: acute dermatitiswet dressing/bath: acute dermatitis
4. Chronic: baths containing oil moisturizers/emmolient5. Itching: hydroxyzine/ diphenhydramineg y y p y
Lichen Simplex ChronicusLichen Simplex ChronicusLichen Simplex ChronicusLichen Simplex Chronicus• Also known as neurodermatitis
i i t / i ib dcircumcripta/ circumscribed neurodermatitis
• Chronic, severely pruritic characterized by one or more lichenified plaques the skin is thickend
• Most common sites: scalp, nape of neck, p, p ,extensor aspects of extremities, ankles,
• Anogenital regionAnogenital region
Etiology and PathogenesisEtiology and PathogenesisEtiology and PathogenesisEtiology and Pathogenesis
• Induced by rubbing and scratchingInduced by rubbing and scratching secondary to itch
• Environmental factors inducing itch• Environmental factors inducing itch• ( heat, sweat, irritation)• Emotional/ psychological factors
(depression, anxiety)
Clinical FindingClinical FindingClinical FindingClinical Finding
• Severe itching (the hallmark of LSC)Severe itching (the hallmark of LSC)• Paroxysmal, continous/ sporadic
R bbi d t hi• Rubbing and scratching• Itch severity is worse with sweating, heat/
irritation from clothing/ psychological distress
Cutaneous LesionsCutaneous LesionsCutaneous LesionsCutaneous Lesions• Repeating rubbing and
t h li h ifi d (thik d ki ithscratch lichenified (thikened skin with accentuated skin marking)
• Scally plaque with excoriations• Hyper and hypopigmentation chronicityyp yp p g y• One plaque or more• Sites: scalp the nape of neck (women)• Sites: scalp, the nape of neck (women)
ankles, extensor aspect o/t extremities, it lanogenital
Pathology LSCPathology LSCPathology LSCPathology LSC
• Hyperkeratosis, hypergranulosis, psoriasisform epidermal hyperplasiapsoriasisform epidermal hyperplasia, thickened papillary dermal collagen
TherapyTherapy
DifficultT ili d ti d tTranquilizer and anti depressantsTopical steroid and intralesional steroid
Xerotic EczemaXerotic EczemaXerotic EczemaXerotic Eczema
• Is the results of low humidity and dry skin
• Clinis: dry fissure skin trunk, extremities(lower leg)
Autosensitization/Id eruptionAutosensitization/Id eruptionAutosensitization/Id eruptionAutosensitization/Id eruption
• - generalized sub acute dermatitisf t/h d• - feet/hands
• - Hypersensitivity reaction to substance produced by the acute dermatitis
Dyshidrotic EczemaDyshidrotic EczemaDyshidrotic EczemaDyshidrotic Eczema
• -Characteristic: deep seated vesicles ( hi h bl th l i t i(which resemble the pearls in tapioca pudding)
• -Palm, soles, side of fingers• -Bilaterally symmetricallyBilaterally, symmetrically
CONTACT DERMATITISCONTACT DERMATITIS
An inflammatory reaction ofAn inflammatory reaction ofAn inflammatory reaction of An inflammatory reaction of the skin precipitated by an the skin precipitated by an
exogenous chemicalexogenous chemical
Contact DermatitisContact Dermatitis1.1. Irritant CD: produced by Irritant CD: produced by
substance that has direct toxic substance that has direct toxic effect on the skineffect on the skin
2.2. Allergic: trigger an Allergic: trigger an immunologic reactionimmunologic reaction tissue tissue gginflammationinflammation
PathogenesisPathogenesisPathogenesisPathogenesis
• Irritant CD: nonspecific inflammatoryIrritant CD: nonspecific inflammatory reactions due toxic injury of the skin
• Allergic CD: Cell mediated immunity/• Allergic CD: Cell mediated immunity/ type IV
A. Sensitization phaseB. Elicitation Phase
Sensitization: hapten + protein LCs Th1
IrritantsIrritantsIrritantsIrritants
Subtances direct toxic effect of the skin• AcidsAcids• Alkalis• Solvents• Solvents• Detergents
AllergensAllergensAllergensAllergens
Triggers immunologic reaction tissueTriggers immunologic reaction tissue inflammation
• Metals• Plants• Rubber chemicalsRubber chemicals• Medicines
Incidence:Incidence:
-- Frequent problemFrequent problem-- 50% occupational illness50% occupational illness
HistoryHistoryHistoryHistory
First determine: ACD/ICDFirst determine: ACD/ICD• Strong irritant several hours skin damage• Weaker irritants multiple application & daysWeaker irritants multiple application & days
dermatitis• Allergic Contact Dermatitis:Allergic Contact Dermatitis:
– Requires 24-48 hours– Often exposure Clinical diseasep– Occasionally dermatitis (8-12 hours) up to 4-7 hours– Detailed history of occupation, hygiene habits, hobbies
The most common SensitizersThe most common Sensitizers
• Poison Ivyy• Para phenylenediamine• Nickel• Rubber compounds• EthylenediamineEthylenediamine• Poison ivy: in the summer
– Allergen: pentadecylcatechol (oleoresin of the plant)Allergen: pentadecylcatechol (oleoresin of the plant)
PPDPPDPPDPPD
• Permanent coloring of hair• Cross reaction : Azo, aniline dye,
Benzocaine procaineBenzocaine, procaine, HydrochlorothiazineSulfonamides
When completely oxidized (fur coat), PPD not allergenic
NickelNickelNickelNickel
• Most commonly in womanMost commonly in woman• Ear piercing
I ll t l• In all metals• “Hypoallergenic” earring: one cannot be
certain that they are free of nickel• Stainless steel: nickel bound so tightlyg y
ACD (-)
Rubber compoundRubber compoundRubber compoundRubber compound
• Shoes ACD on dorsa of the feetAll M t b thi l• Allergen: Mercaptobenzothiazole
Thiurams
EthylenediamineEthylenediamineEthylenediamineEthylenediamine
Preservative in Mycolog cream, ointment (-)Dyes, insecticides, Rubber accelerators, Synthetic waxes, y ,In aminophyllin
Sensitive individual generalizedSensitive individual generalized eczematous dermatitis
Physical ExaminationPhysical ExaminationPhysical ExaminationPhysical Examination
• Acute/chronic• Depend upon the nature of the exposure
patches/plaque, angular corner, geometric on p p q , g , glines, sharp margin
• Localization: Head& neck: cosmetics, hair dyes, permanent waves, shampoosEyelid: eye cosmetic nail polishEyelid: eye cosmetic, nail polishPhoto allergic: produce by a photoreaction between SUV & allergen of the neck armsbetween SUV & allergen, of the neck, arms
Physical ExaminationPhysical ExaminationPhysical ExaminationPhysical Examination
• The dorsum of the hands: industrialThe dorsum of the hands: industrial chemicals (irritants): petroleum, solvents
• The dorsum of the feet: shoes (rubber• The dorsum of the feet: shoes (rubber, leather tanning agents)G i d b tt k i i f t Di• Groins and buttocks in infants: Diaper dermatitis: moisture and feces
DiagnosisDiagnosisDiagnosisDiagnosis
• Patch test: The test material, in different vehiclesPatch test: The test material, in different vehicles (commonly white petrolatum)
• Is applied to the skin under a metal disc, called a pp ,Finn chamber
• A test battery of 20-24 allergens is used as y gstandard allergens
• The sheet is placed on the upper back, scaled with adhesive tape
• The patch is removed after 48 hours read
TherapyTherapyTherapyTherapy
• PreventionPrevention• Avoidance of irritant/allergen change in life
style & occupationy p• Protective clothing• Occupational: protective barrier cream littleOccupational: protective, barrier cream little
benefit• SubstitutedSubst tuted• Topical steroid• AntihistamineAntihistamine
Dermatitis Kontak IritanDermatitis Kontak Iritan
DKI pd tangan & ujungDKI pd tangan & ujung--ujung jari akibat asamujung jari akibat asam
Dermatitis Kontak AlergiDermatitis Kontak AlergiDermatitis Kontak AlergiDermatitis Kontak Alergi
DKA akibat kalung nikelDKA akibat kalung nikel DKA akibat semenDKA akibat semengg
Seborrheic Dermatitis/ Morbus Seborrheic Dermatitis/ Morbus UUUnnaUnna
• Definition: a chronic, superficial, inflammatory process affecting the hairy regions of the body
/• Etiology: unknown/ Pityrosporum ovale
D d ff i li f th l ith tDandruff is scaling of the scalp without inflammation
• Incidence: a common problem 2-5%• Incidence: a common problem, 2-5%adult 18-40 years, baby (cradle cap), children 6-10 years woman> manchildren 6 10 years, woman> man
Seborrheic DermatitisSeborrheic Dermatitis• Predilection hairy
region: scalp eyebrowregion: scalp, eyebrow• eyelid• Nasolabial creases• Nasolabial creases,
ears, chest
HistoryHistoryHistoryHistory
• The occurrence of SeborrheicD titi ll l th i dDermatitis parallels the increased sebaceous gland activity occurring in i f t ft b t itinfant, after puberty, pruritus
Physical examinationPhysical examinationPhysical examinationPhysical examination
• Predilection for the hairy regions where there y gare numerous sebaceous gland: scalp, eyebrows, eyelids, nasolabial creases, ears, chest intertriginous area: axilla groin buttockschest, intertriginous area: axilla, groin, buttocks, infra mammary folds
• Bilateral and symmetricallyBilateral and symmetrically• Most mild form, dandruff, fine whittis scaling
without erythema.• Patch/plaque: indistinct margin, erythema,
yellowish, greasy scaling, uncommon hair loss
Physical examination S.DPhysical examination S.DPhysical examination S.DPhysical examination S.D
• Mild form: dandruff fine whitish scalingMild form: dandruff fine whitish scaling without erythema / Pityriasis sica
• Mild Moderate: erythema yellowish• Mild Moderate: erythema, yellowish greasy scaling
DDDDDDDD1. A.D (infantile eczema)
if i f t L di & illif infant Loc: diaper area & axilladiagnosis S.DIf l i f hi ADIf lesion: forearms, shins AD
2. Psoriasis: scalp, groin, other areapapilosquamous patches &papilosquamous patches & plaque
3 T capitis: hair loss urban black3. T. capitis: hair loss, urban blackBiopsy : non diagnostic
Therapy S.DTherapy S.DTherapy S.DTherapy S.D
• Anti seborrheic shampoos (sulfur salicylicAnti seborrheic shampoos (sulfur, salicylic acid, selenium sulfide, zinc pyrithione)
• Shampoos must be rubbed in to the• Shampoos must be rubbed in to the scalp 5-10 minutesI fl S b h i• Inflam. Seborrrheic:
• topical steroid lot/gel in hairy area; hydrocortisone cream non hairy skin
STASIS DERMATITISSTASIS DERMATITISSTASIS DERMATITISSTASIS DERMATITIS
D fi tiD fi tiDefination:Defination:
An eczematous eruption of the An eczematous eruption of the lower leglower leg secondary to peripheralsecondary to peripherallower leglower leg secondary to peripheral secondary to peripheral venous diseasevenous disease
STASIS DERMATITISSTASIS DERMATITIS
Venous incompetenceVenous incompetence hydrostatichydrostaticVenous incompetence Venous incompetence hydrostatic hydrostatic pressure, capillary damagepressure, capillary damage extravasation of extravasation of red blood cell & serumred blood cell & serum inflammatoryinflammatoryred blood cell & serumred blood cell & serum inflammatory inflammatory eczematous processeczematous process
IncidenceIncidence
• Adults (middle age old age)
• History: Chronicpruritic eruptionpruritic eruptionprecede by edema & swelling
Patients with Stasis dermatitis have oftenPatients with Stasis dermatitis have often had thrombophlebitis
Physical examinationPhysical examination
Varicose vein are prominent1. Edema2. Brown pigmentationg3. Petechiae4. Sub acute and chronic dermatitis5. Thickened skin, scaling and /or weeping6. Any portion of the leg prominent site is6. Any portion of the leg prominent site is
above the medial malleolus
TherapyTherapyTherapyTherapy
- Prevention of venous stasis and edemaPrevention of venous stasis and edema use of supportive hose
- Standing should be restrictedg- Patients who are obese weight reduction- If this fails bed rest with elevation of legsIf this fails bed rest with elevation of legs- Topical steroid- Wet compresses if there is oozing or- Wet compresses if there is oozing or
crusting
HistoryHistory
-- Patient may have history of emotional or Patient may have history of emotional or psychiatric problempsychiatric problem
Physical ExaminationsPhysical ExaminationsPhysical ExaminationsPhysical Examinations
• Patients: anxiousLi h ifi d l t hi ( )• Lichenified plaque, scratching (+)