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CURRICULUM VITAE
Date Prepared: May, 2017
Name: Robert René Henri Anholt, Ph.D.
Primary academic appointment: Department of Biological Sciences
Present academic rank and title: William Neal Reynolds Distinguished Professor
Date of Birth: December 28, 1951
Place of Birth: The Hague, The Netherlands
Nationality: Netherlands and USA; naturalized USA citizen
(January 15, 2011, Durham, NC)
Website: anholt.sciences.ncsu.edu
e-mail: [email protected]; [email protected]
Professional Training and Academic Career
2014-present Member, Comparative Medicine Institute (formerly Center for
Comparative Medicine and Translational Research) North Carolina State
University, Raleigh, North Carolina
2013-present William Neal Reynolds Distinguished Professor of Biological Sciences,
Department of Biological Sciences, North Carolina State University,
Raleigh, North Carolina
2008-2013 William Neal Reynolds Distinguished Professor of Biology, Department
of Biology, North Carolina State University, Raleigh, North Carolina
2007-2017 Adjunct Professor, Department of Endodontics, School of Dentistry,
University of North Carolina, Chapel Hill, North Carolina
2006-present Member of the Comparative Biomedical Sciences Program, College of
Veterinary Medicine, North Carolina State University, Raleigh, North
Carolina
2000- 2008 Professor, Department of Zoology, North Carolina State University,
Raleigh, North Carolina
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2000-2013 Associate Member, Department of Genetics, North Carolina State
University, Raleigh, North Carolina
2000-present Director, W. M. Keck Center for Behavioral Biology, North Carolina State
University, Raleigh, North Carolina
2000-present Member of the Genomics Sciences Faculty, North Carolina State
University, Raleigh, North Carolina
1998-2000 Program Director, W. M. Keck Program for Behavioral Biology, North
Carolina State University, Raleigh, North Carolina.
1996-2000 Associate Professor, Department of Zoology, North Carolina State
University, Raleigh, North Carolina
1993-1996 Research Associate Professor, Department of Zoology, North Carolina
State University, Raleigh, North Carolina
1992-1993 Member, Duke Comprehensive Cancer Center
1988-1993 Assistant Professor, Department of Neurobiology, Duke University
Medical Center, Durham, North Carolina
1986-1988 Assistant Professor, Department of Physiology, Duke University Medical
Center, Durham, North Carolina
1982-1986 Postdoctoral Fellow, Department of Neuroscience, The Johns Hopkins
University School of Medicine, Baltimore, Maryland (Dr. Solomon H.
Snyder, advisor)
1982 Interim Postdoctoral Appointment, The Salk Institute for Biological
Studies, San Diego, California (Dr. Jon Lindstrom, advisor)
1982 Doctor of Philosophy in Biology, University of California, San Diego (Dr.
Mauricio Montal, advisor)
1976-1982 Teaching Assistant, Department of Biology, Univ.California, San Diego
1975-1976 Research Assistant, Department of Pathological Anatomy, Academic
Hospital Wilhelmina Gasthuis, University of Amsterdam, Amsterdam,
The Netherlands
1975 Master of Science in Biochemistry, University College, London, England
1973 Bachelor of Science in Biology (with distinction), The Hebrew University
of Jerusalem, Jerusalem, Israel
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Awards and Special Recognitions
1972 Hebrew University Study Prize
1977-1982 Tuition Scholarship and Earle C. Anthony Scholarship, University of California,
San Diego
1982 Martin Kamen award for most outstanding doctoral thesis, University of
California, San Diego
2000 Faculty Resource Development Award, College of Agriculture and Life Sciences,
North Carolina State University
2006 Sigma Xi membership
Fellow, American Association for the Advancement of Science (AAAS)
2008 Appointed William Neal Reynolds Distinguished Professor of Biology
2011 Named a Top Referee by the Proceedings of the Royal Society B: Biological
Sciences
2016 Alexander Quarles Holladay Medal for Excellence, North Carolina State
University.
2016-2019 Honorary Professorate conferred by Beijing Forestry University, Beijing, China
Research Interests
Research in my laboratory focuses on (1) dissecting the genetic architecture of behavior in
Drosophila melanogaster, including olfactory behavior, startle behavior, phototaxis, aggression
and locomotion; (2) developing Drosophila as a genetic model for identifying ensembles of
genes that predispose to human disorders, including alcohol related phenotypes and ocular
hypertension (a prelude to primary open angle glaucoma) with follow-up association studies in
human populations; (3) understanding the genetic underpinnings of phenotypic plasticity; and,
(4) determining the functions of the olfactomedin gene family.
Publications
1. Jöbsis, A.C., de Vries, G.P., Anholt, R.R.H. and Sanders, G.T.B. (1977) Prostaat zure
fosfatase enzymhistochemisch en immunohistochemisch aangetoond. Ned. Tijdschr.
Geneesk. 121: 1871-1872.
2. Jöbsis, A.C., de Vries, G.P., Anholt, R.R.H. and Sanders, G.T.B. (1978) Demonstration
of the prostatic origin of metastases: An immunohistochemical method for formaline-
fixed embedded tissue. Cancer 41: 1788-1793.
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3. Lindstrom, J., Anholt, R., Einarson, B., Engel, A., Osame, M. and Montal, M. (1980)
Purification of acetylcholine receptors, reconstitution into lipid vesicles, and study of
agonist-induced cation channel regulation. J. Biol. Chem. 255: 8340-8350.
4. Nelson, N., Anholt, R., Lindstrom, J. and Montal, M. (1980) Reconstitution of purified
acetylcholine receptors with functional ion channels in planar lipid bilayers. Proc. Natl.
Acad. Sci. U.S.A. 77: 3057-3061.
5. Anholt, R., Lindstrom, J. and Montal, M. (1980) Functional equivalence of monomeric
and dimeric forms of purified acetylcholine receptors from Torpedo californica in
reconstituted lipid vesicles. Eur. J. Biochem. 109: 481-487.
6. Anholt, R., Lindstrom, J. and Montal, M. (1981) Stabilization of acetylcholine receptor
channels by lipids in cholate solution and during reconstitution in vesicles. J. Biol. Chem.
256: 4377-4387.
7. Anholt, R.R.H. (1981) Reconstitution of acetylcholine receptors in model membranes.
Trends Biochem. Sci. 6: 288-291.
8. Anholt, R., Fredkin, D.R., Deerinck, T., Ellisman, M., Montal, M. and Lindstrom, J.
(1982) Incorporation of acetylcholine receptors into liposomes: Vesicle structure and
acetylcholine receptor function. J. Biol. Chem. 257: 7122-7134.
9. Anholt, R.R.H. (1982) Reconstitution of acetylcholine receptors in model membranes.
Doctoral dissertation, University of California, San Diego.
10. Anholt, R.R.H., Montal, M. and Lindstrom, J. (1983) Incorporation of acetylcholine
receptors in model membranes: An approach aimed at studies of the molecular basis of
neurotransmission. In: Peptide and Protein Reviews (Editor, M.T.W. Hearn), Volume 1,
Chapter 4, pp. 95-137, Marcel Dekker, Inc. New York, NY.
11. Anholt, R. R. H., Murphy, K. M. M., Mack, G. E. and Snyder, S. H. (1984) Peripheral-
type benzodiazepine receptors in the central nervous system: Localization to olfactory
nerves. J. Neurosci. 4: 593-603.
12. Anholt, R. R. H., Lindstrom, J. and Montal, M. (1985) The molecular basis of
neurotransmission: Structure and function of the nicotinic acetylcholine receptor. In: The
Enzymes of Biological Membranes (Editor, A. Martonosi), Volume 3, Chapter 36,
pp.335-401, Plenum Press, New York, NY.
13. De Souza, E. B., Anholt, R. R. H., Murphy, K. M. M., Snyder, S. H. and Kuhar, M. J.
(1985) Peripheral-type benzodiazepine receptors in endocrine organs: Autoradiographic
localization in rat pituitary, adrenal and testis. Endocrinology 116: 567-573.
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14. Anholt, R. R. H., De Souza, E. B., Kuhar, M. J. and Snyder, S. H. (1985) Depletion of
peripheral-type benzodiazepine receptors after hypophysectomy in rat adrenal gland and
testis. Eur. J. Pharmacol. 110: 41-46.
15. Anholt, R. R. H., De Souza, E. B., Oster-Granite, M. L. and Snyder, S. H. (1985)
Peripheral-type benzodiazepine receptors: Autoradiographic localization in whole body
sections of neonatal rat. J. Pharmacol. Exp. Ther. 233: 517-526.
16. Montal, M., Anholt, R. R. H. and Labarca, P. (1986) The reconstituted acetylcholine
receptor. In: Ion Channel Reconstitution (Editor, C. Miller), Chapter 8, pp. 157-204,
Plenum Press, New York, NY.
17. Anholt, R. R. H., Pedersen, P. L., De Souza, E. B. and Snyder, S. H. (1986) The
peripheral-type benzodiazepine receptor: Localization to the mitochondrial outer
membrane. J. Biol. Chem. 261: 576-583.
18. Anholt, R. R. H., Aebi, U., Pedersen, P. L. and Snyder, S. H. (1986) Solubilization and
reassembly of the mitochondrial benzodiazepine receptor. Biochemistry 25: 2120-2125.
19. Anholt, R. R. H. (1986) Mitochondrial benzodiazepine receptors as potential modulators
of intermediary metabolism. Trends Pharmacol. Sci. 7: 506-511.
20. Anholt, R. R. H., Aebi, U. and Snyder, S. H. (1986) A partially purified preparation of
isolated chemosensory cilia from the olfactory epithelium of the bullfrog, Rana
catesbeiana. J. Neurosci. 6: 1962-1969.
21. Sklar, P. B., Anholt, R. R. H. and Snyder, S. H. (1986) The odorant-sensitive adenylate
cyclase of olfactory receptor cells: Differential stimulation by distinct classes of odorants.
J. Biol. Chem. 261: 15538-15543.
22. Anholt, R. R. H., Mumby, S. M., Stoffens, D. A., Girard, P. R., Kuo, J. F., Gilman, A. G.
and Snyder, S. H. (1987) Transduction proteins of olfactory receptor cells: Identification
of guanine nucleotide binding proteins and protein kinase C. Ann. NY Acad. Sci. 510:
152-156.
23. Sklar, P. B., Anholt, R. R. H. and Snyder, S. H. (1987) The odorant-sensitive adenylate
cyclase of olfactory receptor cells: Differential stimulation by distinct classes of odorants.
Ann. NY Acad. Sci. 510: 623-626.
24. Anholt, R. R. H., Mumby, S. M., Stoffers, D. A., Girard, P. R., Kuo, J. F. and Snyder, S.
H. (1987) Transduction proteins of olfactory receptor cells: Identification of guanine
nucleotide binding proteins and protein kinase C. Biochemistry 26: 788-795.
25. Anholt, R. R. H. (1987) Primary events in olfactory reception. Trends Biochem. Sci. 12:
58-62.
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26. Labarca, P., Simon, S. A. and Anholt, R. R. H. (1988) Activation by odorants of a
multistate cation channel from olfactory cilia. Proc. Natl. Acad. Sci. U.S.A. 85: 944-947.
27. Anholt, R. R. H. (1988) Functional reconstitution of the olfactory membrane:
Incorporation of the olfactory adenylate cyclase in liposomes. Biochemistry 27: 6464-
6468.
28. Anholt, R. R. H. (1989) Molecular physiology of olfaction. Am. J. Physiol. 257 (Cell
Physiol. 26): C1043-C1054.
29. Anholt, R. R. H., Farmer, R. W. and Karavanich, C. A. (1989) Excitation by odorants of
olfactory receptor cells: Molecular interactions at the ciliary membrane. In: Chemical
Senses: Molecular Aspects of Taste and Odor Reception (Editors, J. G. Brand, J. H.
Teeter, M. R. Kare and R. H. Cagan) Chapter 17, pp. 347-361, Marcel Dekker, Inc., New
York, NY.
30. Anholt, R. R. H. (1990) Cellular and subcellular localization of peripheral
benzodiazepine receptors: Implications for a possible function in the control of
intermediary metabolism. Eur. J. Pharmacol. 183: 145-146.
31. Anholt, R. R. H., Petro, A. E. and Rivers, A. M. (1990) Identification of a group of novel
membrane proteins unique to chemosensory cilia of olfactory receptor cells. Biochemistry
29: 3366-3373.
32. Anholt, R. R. H. and Rivers, A. M. (1990) Olfactory transduction: Crosstalk between
second messenger systems. Biochemistry 29: 4049-4054.
33. Zarbin, M. A. and Anholt, R. R. H. (1991) Benzodiazepine receptors in the eye. Invest.
Ophthalmol. Vis. Sci. 32: 2579-2587.
34. Snyder, D. A., Rivers, A. M., Yokoe, H., Menco, B. Ph.M. and Anholt, R. R. H. (1991)
Olfactomedin: Purification, characterization and localization of a novel olfactory
glycoprotein. Biochemistry 30: 9143-9153.
35. Anholt, R. R. H. (1991) Odor recognition and olfactory transduction: The new frontier.
Chemical Senses 16: 421-427.
36. Anholt, R. R. H. (1992) Molecular aspects of olfaction. In: Science of Olfaction (Editors,
M. Serby and K. Chobor) Chapter 3, pp. 51-79, Springer-Verlag, New York, NY.
37. Anholt, R. R. H. (1993) Molecular neurobiology of olfaction. Critical Rev. Neurobiol. 7:
1-22.
38. Bal, R. S. and Anholt, R. R. H. (1993) Formation of the extracellular mucous matrix of
olfactory neuroepithelium: Identification of partially and non-glycosylated precursors of
olfactomedin. Biochemistry 32: 1047-1053.
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39. Yokoe, H. and Anholt, R. R. H. (1993) Molecular cloning of olfactomedin, an
extracellular matrix protein specific to olfactory neuroepithelium. Proc. Natl. Acad. Sci.
U.S.A. 90: 4655-4659.
40. Anholt, R. R. H. (1994) Signal integration in the nervous system: Adenylate cyclases as
molecular coincidence detectors. Trends Neurosci. 17: 37-41.
41. Menini, A. and Anholt, R. R. H. (1994) Cyclic nucleotide-activated channels. In:
Endocrinology and Metabolism. Progress in Research and Clinical Practice. Vol. 6. Ion
Channels and Ion Pumps: Metabolic and Endocrine Relationships in Biology and
Clinical Medicine (Editors, P. P. Foa and M. F. Walsh), Chapter 24, pp. 526-548,
Springer-Verlag, New York, NY.
42. Anholt, R. R. H. (1994) Dazzle’em with style: The art of oral scientific presentation. W.
H. Freeman and Company, New York, NY.
43. Anholt, R. R. H. (1995) Preparation of olfactory cilia. In: Experimental Cell Biology of
Taste and Olfaction: Current Techniques and Protocols (Editors, A. I. Spielman and J. G.
Brand), CRC Press, Inc., Boca Raton, Fl., pp. 163-168.
44. Anholt, R. R. H., Lyman, R. F. and Mackay, T. F. C. (1996) Effects of single P-element
insertions on olfactory behavior in Drosophila melanogaster. Genetics 143: 293-301.
45. Mackay, T. F. C., Hackett, J. B., Lyman, R. F. Wayne, M. L. and Anholt, R. R. H. (1996)
Quantitative genetic variation of odor-guided behavior in a natural population of
Drosophila melanogaster. Genetics 144: 727-735.
46. Wekesa, K. S. and Anholt, R. R. H. (1997) Pheromone-regulated production of inositol-
(1,4,5)-trisphosphate in the mammalian vomeronasal organ. Endocrinology 138: 3497-
3504.
47. Karavanich, C. and Anholt, R. R. H. (1998) Evolution of olfactomedin: Structural
constraints and conservation of primary sequence motifs. Ann. NY Acad. Sci. 855:294-
300.
48. Fedorowicz, G. M., Fry, J. D., Anholt, R. R. H. and Mackay, T. F. C. (1998) Epistatic
interactions between smell-impaired loci in Drosophila melanogaster. Genetics 148:
1885-1891.
49. Karavanich, C. A. and Anholt, R. R. H. (1998) Molecular evolution of olfactomedin.
Mol. Biol. Evol. 15: 718-726.
50. Wekesa, K. S. and Anholt, R. R. H. (1999) Differential expression of G proteins in the
mouse olfactory system. Brain Research 837: 117-126.
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51. Kulkarni, N. H., Karavanich, C. A, Atchley, W. R. and Anholt, R. R. H. (2000)
Characterization and differential expression of a human gene family of olfactomedin-
related proteins. Genet. Res. 76: 41-50.
52. Anholt, R. R. H. and Mackay, T. F. C. (2001) The genetic architecture of odor-
guided behavior in Drosophila melanogaster. Behav. Genet. 31: 17-27.
53. Anholt, R. R. H., Fanara, J. J., Fedorowicz, G. M., Ganguly, I., Kulkarni, N. H., Mackay,
T. F. C. and Rollmann, S. M. (2001) Functional genomics of odor-guided behavior in
Drosophila melanogaster. Chem. Senses 26: 215-221.
54. Kulkarni, N. H., Yamamoto, A., Robinson, K. O., Mackay, T. F. C. and Anholt, R. R. H.
(2002) The DSC1 channel, encoded by the smi60E locus, contributes to odor-guided
behavior in Drosophila melanogaster. Genetics 161: 1507-1516.
55. Luo, A. H., Cannon, E. H., Wekesa, K. S., Lyman, R. F., Vandenbergh, J. G. and Anholt,
R. R. H. (2002) Impaired olfactory behavior in mice deficient in the α subunit of Go.
Brain Res. 941: 62-71.
56. Fanara, J. J., Robinson, K. O., Rollmann, S. M., Anholt, R. R. H. and Mackay, T. F. C.
(2002) Vanaso is a candidate quantitative trait gene for olfactory behavior in Drosophila
melanogaster. Genetics 162:1321-1328.
57. Borrás, T., Morozova, T. V., Heinsohn, S. L., Lyman, R. F., Mackay, T. F. C. and
Anholt, R. R. H. (2003) Transcription profiling in Drosophila eyes that overexpress the
human glaucoma-associated trabecular meshwork-inducible glucocorticoid response
protein/myocilin (TIGR/MYOC). Genetics 163: 637-645.
58. Ganguly, I., Mackay, T. F. C. and Anholt, R. R. H. (2003) scribble is essential for
olfactory behavior in Drosophila. Genetics 164: 1447-1457.
59. Anholt, R. R. H., Dilda, C. L., Chang, S., Fanara, J.J., Kulkarni, N. H., Ganguly, I.,
Rollmann, S. M., Kamdar, K. P. and Mackay, T. F. C. (2003) The genetic architecture of
odor-guided behavior in Drosophila: Epistasis and the transcriptome. Nature Genetics
35:180-184.
60. Anholt, R. R. H. (2004) Genetic modules and networks for behavior: Lessons from
Drosophila. BioEssays 26: 1299-1306.
61. Anholt, R. R. H. and Mackay, T. F. C. (2004) Quantitative genetic analyses of complex
behaviours in Drosophila. Nature Reviews Genetics 5: 838-849.
62. Rollmann, S. M., Mackay, T. F. C. and Anholt, R. R. H. (2005) Pinocchio, a novel
protein expressed in the antenna, contributes to olfactory behavior in Drosophila
melanogaster. J. Neurobiol. 63: 146-158.
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63. Anholt, R. R. H. (2005) Dazzle’em with style: The art of oral scientific presentation.
Second Edition, Elsevier/Academic Press, New York, NY. (Translated in Japanese by
Ohno Suzuki (2008) Kodansha Publishers, Inc. Tokyo, Japan).
64. Rollmann, S. M., Magwire, M. M., Morgan, T. J., Özsoy, E. D., Yamamoto, A., Mackay,
T. F. C. and Anholt, R. R. H. (2006) Pleiotropic fitness effects of the Tre1/Gr5a region
in Drosophila. Nature Genetics 38: 824-829.
65. Mackay, T. F. C. and Anholt, R. R. H. (2006) Of flies and man: Drosophila as a model
for human complex traits. Annu. Rev. Genomics Hum. Genet. 7: 339-367.
66. Morozova, T. V., Anholt, R. R. H. and Mackay, T. F. C. (2006) Transcriptional response
to alcohol exposure in Drosophila melanogaster. Genome Biol. 7: R95. [Highly
Accessed]
67. Sambandan, D., Yamamoto, A., Fanara, J. J., Mackay, T. F. C. and Anholt, R. R. H.
(2006) Dynamic genetic interactions determine odor-guided behavior in Drosophila
melanogaster. Genetics 174:1349-1363.
68. Mackay, T. F. C. and Anholt, R. R. H. (2007) Aint misbehavin’? Genotype by
environment interactions and the genetics of behavior. Trends Genet. 23: 311-314.
69. Rollmann, S. M., Yamamoto, A., Goossens, T., Zwarts, L., Callaerts-Végh, Z., Callaerts,
P., Norga, K., Mackay, T. F. C. and Anholt, R. R. H. (2007) The early developmental
gene Semaphorin 5c contributes to olfactory behavior in adult Drosophila. Genetics 176:
947-956.
70. Wang, P., Lyman, R. F., Shabalina, S., Mackay, T. F. C. and Anholt, R. R. H. (2007)
Association of polymorphisms in odorant binding protein genes with variation in
olfactory response to benzaldehyde in Drosophila. Genetics 177:1655-1665.
71. Morozova, T. V., Anholt, R. R. H. and Mackay, T. F. C. (2007) Phenotypic and
transcriptional response to selection for alcohol sensitivity in Drosophila melanogaster.
Genome Biol. 8: R231. [Highly Accessed]
72. Lee, J. A, Anholt, R. R. H. and Cole G. J. (2008) Olfactomedin-2 mediates development
of the anterior central nervous system in zebrafish. Mech. Dev. 125: 167-181.
73. Lavagnino, N., Anholt, R. R. H. and Fanara, J. J. (2008) Variation in genetic architecture
of olfactory behavior among natural populations of Drosophila melanogaster. J. Evol.
Biol. 21: 988-996.
74. Rollmann, S. M., Edwards, A. C., Yamamoto, A., Zwarts, L., Callaerts, P., Norga, K.,
Mackay, T. F. C. and Anholt, R. R. H. (2008) Pleiotropic effects of Drosophila
neuralized on complex behaviors and brain structure. Genetics 179: 1327-1336.
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75. Yamamoto, A., Zwarts, L., Norga, K., Callaerts, P., Mackay, T. F. C. and Anholt, R. R.
H. (2008) Neurogenetic networks for startle-induced locomotion in Drosophila. Proc.
Natl. Acad. Sci. U. S. A. 105: 12393-12398.
76. Sambandan, D., Carbone, M. A., Mackay, T. F. C. and Anholt, R. R. H. (2008)
Phenotypic plasticity and genotype by environment interaction for olfactory behavior in
Drosophila melanogaster. Genetics 179: 1079-1088.
77. Anholt, R. R. H. (2009) Olfaction in invertebrates: Drosophila. In: Encyclopedia of
Neuroscience (L. R. Squire, Ed.), volume 7, pp 35-41, Elsevier Academic Press, Oxford,
UK.
78. Carbone, M. A., Ayroles, J. F., Yamamoto, A., Morozova, T. V., West, S. A., Magwire,
M. M., Mackay, T. F. C. and Anholt, R. R. H. (2009) Overexpression of myocilin in the
Drosophila eye activates the unfolded protein response: Implications for glaucoma. PLoS
One 4: e4216.
79. Ayroles, J. F., Carbone, M. A., Stone, E. A., Jordan, K. W., Lyman, R. F., Magwire, M.
M., Rollmann, S. M., Duncan, L. H., Lawrence, F., Anholt, R. R. H. and Mackay, T. F.
C. (2009) Systems genetics of complex traits in Drosophila melanogaster. Nature
Genetics 41: 299-307.
80. Morozova, T. V., Ayroles, J. F., Jordan, K. W., Duncan, L. H., Carbone, M. A., Lyman,
R. F., Stone, E. A., Govindaraju, D. R., Ellison, C. R., Mackay, T. F. C. and Anholt, R.
R. H. (2009) Alcohol sensitivity in Drosophila: Translational potential of systems
genetics. Genetics 83: 733-745.
81. Anholt, R. R. H. and Mackay, T. F. C. (2009) Principles of Behavioral Genetics. Elsevier
Academic Press, Oxford, UK.
Reprinted in 2012 by KE’AI Communications for distribution in China.
82. Zhou, S., Stone, E. A., Mackay, T. F. C. and Anholt, R. R. H. (2009) Plasticity of the
chemoreceptor repertoire in Drosophila melanogaster. PLoS Genet. 5: e1000681.
83. Harbison, S. T., Mackay, T. F. C. and Anholt, R. R. H. (2009) Understanding the
neurogenetics of sleep: Progress from Drosophila. Trends Genet. 25: 262-269.
84. Yamamoto, A., Anholt, R. R. H. and Mackay, T. F. C. (2009) Epistatic interactions
attenuate mutations that affect startle behaviour in Drosophila melanogaster. Genet. Res.
91: 373-382.
85. Anholt, R. R. H. and Islam Williams, T. (2010) The soluble proteome of the Drosophila
antenna. Chemical Senses 35: 21-30.
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86. Wang, P., Lyman, R. F., Mackay, T. F. C. and Anholt, R. R. H. (2010) Natural variation
in odorant recognition among odorant binding proteins in Drosophila melanogaster.
Genetics 184: 745-758.
87. Rollmann, S. M., Wang, P., Date, P., West, S. A., Mackay, T. F. C. and Anholt, R. R. H.
(2010) Odorant receptor polymorphisms and natural variation in olfactory behavior in
Drosophila melanogaster. Genetics, 186: 687-697.
88. Arya, G. H., Weber, A. L., Wang, P., Magwire, M. M., Serrano Negron, Y. L., Mackay,
T. F. C. and Anholt, R. R. H. (2010) Natural variation, functional pleiotropy and
transcriptional networks of Odorant binding protein genes in Drosophila melanogaster.
Genetics 186: 1475-1485.
89. Zhou, S., Mackay, T. F. C. and Anholt, R. R. H. (2010) Tuning the chemosensory
window: A fly’s perspective. Fly 4: 230-235.
90. Swarup, S., Islam Williams, T. and Anholt R. R. H. (2011) Functional dissection of
Odorant binding protein genes in Drosophila melanogaster. Genes Brain Behav. 10:
648-657.
91. Anholt, R. R. H. (2011) Making scents of behavioral genetics: Lessons from Drosophila.
Genet. Res. 92: 349-359.
92. Morozova, T. V., Mackay, T. F. C. and Anholt, R. R. H. (2011) Transcriptional networks
for alcohol sensitivity in Drosophila melanogaster. Genetics 187: 1193-1205.
93. Carbone, M. A., Chen, Y., Hughes, G. A., Weinreb, R., Zabriskie, N., Zhang, K. and
Anholt, R. R. H. (2011) Genes of the unfolded protein response pathway harbor risk
alleles for primary open angle glaucoma. PLoS One 6: e20649.
94. Zwarts, L., Magwire, M. M., Carbone, M. A., Versteven, M., Herteleer, L., Anholt, R. R.
H., Callaerts, P. and Mackay, T. F. C. (2011) Complex genetics architecture of
Drosophila aggressive behavior. Proc. Natl. Acad. Sci. U.S.A. 108: 17070-17075.
95. Zhou, S., Campbell, T. G., Stone, E. A., Mackay, T. F. C. and Anholt, R. R. H. (2012)
Phenotypic plasticity of the Drosophila transcriptome. PLoS Genetics 8: e1002593.
96. Mackay, T. F. C., Richards, S., Stone, E. A., Barbadilla, A., Ayroles, J. F., Zhu , D.,
Casillas, S., Magwire, M. M., Cridland, J. M., Richardson, M. F., Anholt, R. R. H.,
Barrón, M., Bess, C., Blankenburg, K. P., Carbone, M. A., Castellano, D., Chaboub, L.,
Duncan, L., Han, Y., Harris, Z., Javaid, M., Jayaseelan, J. C., Jhangiani, S. N., Jordan,
K. W., Lara, F., Lawrence, F., Lee, S. L., Librado, P., Linheiro, R. S., Lyman, R. F.,
Mackey, A. J., Munidasa, M., Muzny, D. M., Nazareth, L., Newsham, I., Perales, L., Pu,
L-L., Qu, C., Ràmia, M., Reid, J. G., Rollmann, S. M., Rozas, J., Turlapati, L., Worley,
K. C., Wu, Y-Q, Yamamoto, A., Zhu, Y., Bergman, C. M., Thornton, K., Mittleman, D.
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and Gibbs, R. A. (2012) The Drosophila melanogaster Genetic Reference Panel. Nature
482: 173-178.
97. Swarup, S., Harbison, S. T., Hahn, L. E., Morozova, T. V., Yamamoto, A., Mackay, T. F.
C. and Anholt, R. R. H. (2012) Extensive epistasis for olfactory behavior, sleep and
waking activity in Drosophila melanogaster. Genet. Res. 94: 9-20.
98. Morozova, T. V., Goldman, D., Mackay, T. F. C. and Anholt, R. R. H. (2012) The
genetic basis of alcohol consumption: Multiple phenotypes, many genes, complex
networks. Genome Biol. 13: 239. [Highly Accessed]
99. Anholt, R. R. H. and Mackay, T. F. C. (2012) Genetics of aggression. Annu. Rev. Genet.
46: 145-164.
100. Weber, A. L., Khan, G. F., Magwire, M. M., Tabor, C. L., Mackay, T. F. C. and Anholt,
R. R. H. (2012) Genome-wide association for oxidative stress resistance in Drosophila
melanogaster. PLoS One 7: e34745.
101. Jordan, K. W., Craver, K. L., Magwire, M. M., Cubilla, C. E., Mackay, T. F. C. and
Anholt, R. R. H. (2012) Genome-wide association for sensitivity to chronic oxidative
stress in Drosophila melanogaster. PLoS One 7: e38722.
102. Huang, W., Richards, S., Carbone, M. A., Zhu, D., Anholt, R. R. H., Ayroles, J. F.,
Duncan, L., Jordan, K. W., Lawrence, F., Magwire, M. M., Warner, C. B., Blankenburg,
K., Han, Y., Javaid, M., Jayaseelan, J., Jhangiani, S. N., Muzny, D., Ongeri, F., Perales,
L.,Wu, Y. Q., Zhang, Y., Zou, X., Stone, E. A., Gibbs, R. A. and Mackay, T. F. C. (2012)
Epistasis dominates the genetic architecture of Drosophila quantitative traits. Proc. Natl.
Acad. Sci. U.S.A. 109: 15553-15559.
103. Swarup, S., Huang, W., Mackay, T. F. C. and Anholt, R. R. H. (2013) Analysis of natural
variation reveals neurogenetic networks for Drosophila olfactory behavior. Proc. Natl.
Acad. Sci. U.S.A. 110: 1017-1022.
104. Anholt, R. R. H. and Carbone, M. A. (2013) A molecular mechanism for glaucoma:
Endoplasmic reticulum stress and the unfolded protein response. Trends Mol. Med. 19:
586-593.
105. Anholt, R. R. H., Mackay, T. F. C. and Stone, E. A. (2014) Systems genetics of behavior
in Drosophila melanogaster. In: Behavioral genetics of the fly (Drosophila
melanogaster) (Ed. J. Dubnau), pp. 217-230, Cambridge University Press, Cambridge,
UK.
106. Swarup, S., Morozova, T. V., Sridhar, S., Nokes, M. and Anholt, R. R. H (2014)
Modulation of feeding behavior by odorant-binding proteins in Drosophila melanogaster.
Chemical Senses 39: 125-132.
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107. Anholt, R. R. H. (2014) Olfactomedin proteins: Central players in development and
disease. Front. Cell Dev. Bio. 2: 6.
108. Morozova, T. V., Mackay, T. F. C. and Anholt, R. R. H. (2014) Genetics and genomics
of alcohol sensitivity. Mol. Genet. Genomics 289: 253-269.
109. Huang, W., Massouras, A., Inoue, Y., Peiffer, J., Ràmia, M., Tarone, A. M., Turlapati, T.,
Zichner, T., Zhu, D., Lyman, R. F., Magwire, M. M., Blankenburg, K., Carbone, M. A.,
Chang, K., Ellis, L. L., Fernandez, S., Han, Y., Highnam, G., Hjelmen, C. E., Jack, J. R.,
Javaid, M., Jayaseelan, J., Kalra, D., Lee, S., Lewis, L., Munidasa, M., Ongeri, F., Patel,
S., Perales, L., Perez, A., Pu, L., Rollmann, S. M, Ruth, R., Saada, N., Warner, C.,
Williams, A., Wu, Y-Q., Yamamoto, A., Zhang, Y., Zhu, Y., Anholt, R. R. H., Korbel, J.
O., Mittelman, D., Muzny, D. M., Gibbs, R. A., Barbadilla, A., Johnston, J. S., Stone, E.
A., Richards, S., Deplancke, B. and Mackay, T. F. C. (2014) Natural variation in genome
architecture among 205 Drosophila melanogaster Genetic Reference Panel lines.
Genome Res. 24:1193-1208.
110. Zhou, S., Mackay, T. F. C. and Anholt, R. R. H. (2014) Transcriptional and epigenetic
responses to mating and aging in Drosophila melanogaster. BMC Genomics 15: 927.
[Highly Accessed]
111. Montgomery, S. L., Huang, W, Anholt, R. R. H., Mackay, T. F. C. and Rand, M. D.
(2014) Genome-wide association analysis of tolerance to methylmercury toxicity in
Drosophila implicates myogenic and neuromuscular developmental pathways. PLoS One
9: e110375.
112. Anholt, R. R. H. and Mackay, T. F. C. (2015) Dissecting the genetic architecture of
behavior in Drosophila melanogaster. Curr. Opin. Behav. Sci. 2:1-7.
113. Arya, G. H., Magwire, M. M., Huang, W., Serrano-Negron, Y. L., Mackay, T. F. C. and
Anholt R. R. H. (2015) The genetic basis for variation in olfactory behavior in
Drosophila melanogaster. Chemical Senses 40: 233-243.
114. Shorter, J., Couch, C., Huang, W., Carbone, M. A., Peiffer, J., Anholt, R. R. H. and
Mackay, T. F. C. (2015) Genetic architecture of natural variation in Drosophila
melanogaster aggressive behavior. Proc. Natl. Acad. Sci. U.S.A. 112: E3555-E3563.
115. Huang, W., Carbone, M. A., Magwire, M. M., Peiffer, J. A., Lyman, R. F., Stone, E. A.,
Anholt, R. R. H. and Mackay, T. F. C. (2015) Genetic basis of transcriptome diversity
in Drosophila melanogaster. Proc. Natl. Acad. Sci. U.S.A. 112: E6010-E6019.
116. Morozova, T. V., Huang, W., Pray, V. A., Whitham, T., Anholt, R. R. H. and Mackay, T.
F. C. (2015) Polymorphisms in early neurodevelopmental genes affect natural variation
in alcohol sensitivity in adult Drosophila. BMC Genomics 16: 865.
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117. Dembeck, L. M., Böröczky, K., Huang, W., Schal, C., Anholt, R. R. H. and Mackay, T.
F. C. (2015) The genetic basis of natural variation in cuticular hydrocarbon composition
in Drosophila melanogaster. eLife 4: e09861.
118. He, X., Zhou, S., St. Armour, G. E., Mackay, T. F. C. and Anholt, R. R. H. (2016)
Epistatic partners of neurogenic genes modulate Drosophila olfactory behavior. Genes
Brain Behav. 15: 280-290.
119. Zhou, S., Morozova, T. V., Hussain, Y. N., Luoma, S. E., McCoy, L., Yamamoto, A.,
Mackay, T. F. C. and Anholt, R. R. H. (2016) The genetic basis for variation in
sensitivity to lead toxicity in Drosophila melanogaster. Environ. Health Perspect. 124:
1062-1070.
120. Carbone, M. A., Yamamoto, A., Huang, W., Lyman, R. A., Brune Meadors, T.,
Yamamoto, R., Anholt, R. R. H. and Mackay, T. F. C. (2016) Genetic architecture of
natural variation in visual senescence in Drosophila. Proc. Natl. Acad. Sci. U.S.A. 113:
E6620-E6629.
121. Shorter, J. R., Dembeck, L. M., Everett, L. J., Morozova, T. V., Arya, G. H., Turlapati,
L., St. Armour, G. E., Schal, C., Mackay, T. F. C. and Anholt, R. R. H. (2016) Obp56h
modulates mating behavior in Drosophila melanogaster. G3: Genes, Genomes, Genetics
6: 3335-3342.
122. Sophia Fochler, S., Morozova, T. V., Davis, M. R., Gearhart, A. W., Huang, W.,
Mackay, T. F. C. and Anholt, R. R. H. (2017) Genetic variation in alcohol consumption
in Drosophila melanogaster. Genes Brain Behav., revision resubmitted.
123. Zhou, S., Luoma, S. E., St. Armour, G. E., Thakkar, E., Mackay, T. F. C. and Anholt, R.
R. H. (2017) A Drosophila model for toxicogenomics: Genetic variation in susceptibility
to heavy metal exposure. PLoS Genetics, under revision.
124. Garcia, J. F., Carbone, M. A., Mackay, T. F. C. and Anholt, R. R. H. (2017) Regulation
of Drosophila lifespan by bellwether promoter alleles. Scientific Reports, in press.
125. Anholt, R. R. H. and Mackay, T. F. C. (2017) The road less traveled: From genotype to
phenotype in flies and humans. Mamm. Genome, in preparation.
Patents and Inventions
1. Anholt, R. R. H. and Mackay, T. F. C. (1994) Use of pyrazines and thiazoles as fly
repellents. Patent disclosure NCSU 95-2.
2. Anholt, R. R. H. and Mackay, T. F. C. (2001) Targeted overexpression of the human
trabecular meshwork inducible glucocorticoid response (TIGR) protein in the eye of
Drosophila melanogaster as a model for glaucoma. Patent disclosure NCSU 01-173.
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3. Anholt, R. R. H., Carbone, M. A. and Zhang, K. (2010) Polymorphisms for primary open
angle glaucoma as diagnostic indicators for disease liability. Patent disclosure 10065.
Book Reviews
1,2. Neurobiology of Taste and Smell (Editors, T. E. Finger and W. L. Silver) John Wiley and
Sons, New York, NY, 1987. Reviewed by R. R. H. Anholt. The FASEB Journal (1987)
1: 156, and Trends Neurosci. (1988) 11: 83-84.
3. Molecular Neurobiology of the Olfactory System: Molecular, Membranous, and
Cytological Studies (Editors, F. L. Margolis and T. V. Getchell) Plenum Press, New
York, NY, 1988. Reviewed by R. R. H. Anholt. Trends Neurosci. (1989) 12: 122-123.
4. The Vertebrate Olfactory System: Chemical neuroanatomy, Function and Development
(N. Halász) Akadémiaia Kiadó, Budapest, 1990. Reviewed by R. R. H. Anholt. Science
(1991) 252: 321.
5. Zanders, E. and L. MacLeod, L. (2010) Presentation Skills for Scientists. Cambridge
University Press, Cambridge, UK. Reviewed by R. R. H. Anholt. Genet. Res. (2010) 92:
323-324.
Professional Service
1985 Invited participant to the Army Research Office Study Group on “Initial mechanisms in
olfaction” (April 29, 1985, Sarasota, Florida).
Invited participant to the NATO Advanced Research Workshop on “Molecular
mechanisms in vertebrate olfaction” (August 16-22, 1985, University of Warwick,
Coventry, United Kingdom).
1986 Consultant, Universidad Central del Caribe, Escuela de Medicina, Department of
Biochemistry, Cayey, Puerto Rico (May, 1986).
1989 Member of the National Defense Science and Engineering Graduate Fellowship Program
(Battelle) evaluation panel (March, 1989).
1991 Member of the Program Committee for the Thirteenth Annual Meeting of the Association
for Chemoreception Sciences (1991, Sarasota, Florida).
1996 Co-organizer of the U.S. Army Research Office sponsored Workshop-Conference on
“Response and Adaptation to the Environment” (Research Triangle Park, NC, 1996).
1998 Ad hoc reviewer Special Emphasis Panel, National Institutes of Health.
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Ad hoc member of the IFCN-4 (Integrative, Functional and Cognitive Neuroscience-4)
Study Section, National Institutes of Health.
1999- 2003 Member of the IFCN-4 (Integrative, Functional and Cognitive Neuroscience-4)
Study Section, National Institutes of Health.
1999 Participant in the Annual Review and member of the Advisory Review Committee of the
Multidisciplinary Research Program of the University Initiative (MURI) of the
Department of Defense on “Understanding Olfaction: From Detection to Classification”
at the Division of Biology, California Institute of Technology, Pasadena, CA.
2000 Invited participant in the conference on “Chemical Ecology in the Postgenomic Era” at
Ringberg Castle, Max Planck Institute, Germany.
Chair of a Symposium on “Olfaction in Drosophila: from Receptors to Behavior” at the
XXIInd meeting of the Association for Chemoreception Sciences (Sarasota, FL)
2001 Invited participant in the conference on “Quantitative Evolutionary Genetics: Drosophila
in the Post-Genome Era” at the Fondation Les Treilles, France.
Invited participant at the External Advisory Committee meeting of the Center for
Behavioral Neuroscience at Emory University and invited speaker in the Atlanta Chapter
for the Society of Neuroscience Spring Symposium on “Olfactory Coding, Plasticity, and
Memory.”
Ad hoc member of the NIH Small Business Innovative Research (SBIR) grant Study
Sections (April and July, 2001)
Chair of the session on “The Vomeronasal Signal” at the Gordon Research Conference
on Chemical Senses: Taste & Smell, Salve Regina University, Newport, RI.
NIH Special Emphasis Panel ZRG1-IFCN5-07
Participation in the Annual Biomedical Research Conference for Minority Students
(Orlando, FL)
2002 NIH Special Emphasis Panel
2003 NIH fellowship review panel ZRG1-F02B
Consultant at the Bascom Palmer Eye Institute, University of Miami, to deliver a
workshop on techniques of oral scientific presentation.
Invited participant to the National Academies Keck Futures Initiative Conference, Arnold
and Mabel Beckman Center, Irvine, CA.
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Participation in the Annual Biomedical Research Conference for Minority Students (San
Diego, CA)
2003-2004 Member of the NIH Somatosensory and Chemosensory Systems (formerly
IFCN-4) Study Section.
2004 Participation in the Annual Biomedical Research Conference for Minority Students
(Dallas, TX)
Workshop on techniques of oral scientific presentation at CIIT Health Science Center,
Research Triangle Park, NC.
Organizer and moderator of the 2004 W. M. Keck Center for Behavioral Biology
Professional Development Workshop on “Science Writing for Success”, NCSU College
of Veterinary Medicine, Raleigh, NC.
2004-2007 Member of the Advisory Committee of the NIH sponsored Research
Infrastructure for Minority Institutions (RIMI) program at Alabama State
University.
2005 Workshop on techniques of oral scientific presentation at Michigan State University (East
Lansing, MI).
Ad hoc reviewer of the NIH Somatosensory and Chemosensory Systems Study Section
and the NIMH Conte Center Review panel (ZMHI ERB-S (08)).
Invited speaker at the University of Leuven and the University of Antwerp (Belgium).
Chair of a symposium on “The Genetic Basis of Phenotypic Variation in Behavior in
Drosophila melanogaster”at the International Behavioral and Neural Genetics Society
Conference (Sitges, Spain).
Participant in the Gordon Research Conference on Evolutionary and Ecological
Functional Genomics (Oxford, UK).
Invited speaker at a workshop entitled “Brain: Genes & Behaviour” at Lund University
(Sweden).
2006 Participant and session chair in the Gordon Research Conference on Genes and Behavior
(Ventura, CA).
Invited symposium speaker at the 49th Annual Conference of The Genetics Society of
Canada (London, Ontario, Canada) and the 17th International Congress of Eye Research
(Buenos Aires, Argentina).
-18-
Invited speaker to present a workshop on oral scientific presentation during the annual
retreat of the Department of Human Genetics, University of Michigan, Ann Arbor.
Ad hoc reviewer at the Somatosensory and Chemosensory Systems (SCS) Study Section
and the Anterior Eye Disease (AED) Study Section at the National Institutes of Health.
Invited symposium speaker at the International Congress for Eye Research, Buenos
Aires, Argentina.
Invited seminar at the University of Buenos Aires, Argentina.
2007 Associate Editor, Genetics (2007-2013)
Associate Editor, Genetics Research (2007-2012)
Chair, NIAAA Special Emphasis Panel ZAA1BB92-1, Exploratory Alcohol Center Grant
Applications Review
Invited participant in a workshop on Evolution of Motor Patterns of the National Science
Foundation (Arlington, VA).
2008 Ad hoc member of the NIH Somatosensory and Chemosensory Systems (SCS) study
section and the NIH Vector Biology study section.
Co-organizer of the 2008 American Genetic Association Symposium on “Genetics and
Genomics of Behavior” (Raleigh, NC).
Chair and invited speaker in a session on behavioral genetics at the keystone conference
on “Complex Traits: Biologic and Therapeutic Insights” (Santa Fe, NM).
2009 Member of the NIH R03 Chemical Senses study section, the NIH Vector Biology study
section and the ARRA AREA grant ZRG1 CB-N (52) study section.
Invited seminars at Cambridge University, the University of Zürich, Washington
University (St. Louis), Wake Forest University, and Pennsylvania State University.
2010 Member of an NIEHS study section (ZES1 LWJ-V-01) to review career development and
pathway to independence applications, and the CDRC study section to review predoctoral
and postdoctoral national research service award applications.
Section chair and organizer of the Junior Scientist Talks and poster session at the Gordon
Research Conference on Genes and Behavior (Ventura, CA).
Ad hoc member of the NIH Vector Biology study section.
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Invited seminars at Georgia State University, the University of North Carolina at Chapel
Hill and the University of Kentucky.
2011 Invited plenary lecture at the European Chemoreception Research Conference
(Manchester, UK) and invited seminars at Yale University and Duke University.
2012 Awards Committee, Association for Chemoreception Sciences (AChemS) (2012-2014).
Presentation Skills Workshop and research seminar at the Laboratory of Molecular
Biology of the Medical Research Council, University of Cambridge, UK
Reviews Editor, Genetics Research
Ad hoc member of the NIH Somatosensory and Chemosensory Systems study section.
Invited speaker in a symposium on “New Developments in Quantitative and Population
Genetics of Drosophila” at the Georg August Universität Göttingen, Germany, and
presentations at the 4th International Congress on Quantitative Genetics, Edinburgh,
Scotland, and the International Symposium on Olfaction and Taste, Stockholm, Sweden.
Guest Editor, PLoS Biology
Guest Editor, PLoS Genetics
2013 Program Committee, Association for Chemoreception Sciences (AChemS) (2013-2015)
NIH fellowship review panel (ZDC1 SRB-K(14) Study Section).
Guest Editor, PLoS Genetics
Invited plenary speaker, Annual Conference of the German Genetics Society
(Braunschweig, Germany).
NIH NINDS NST-2 study section for F31 and K99/R00 reviews.
Knovel Virtual Conference Webinar speaker “Dazzle ‘Em with Style: The Art of Oral
Scientific Presentation.”
Invited instructor for the Latin American School of Evolution, Buenos Aires, Argentina.
2014 NIH ZRG1 EMNR-Q (50) Special Emphasis Panel
Editorial Board, Axios Review (2014-2017)
Invited seminar speaker, Department of Biological Sciences, Lund University, Sweden
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2015 NIDCD ZDC1-SRBK17 Chemical Senses Individual Pre- and Post-doctoral Fellowships
Review Study Section
Editorial Board Member, Scientific Reports (2015-present)
NIDCD ZDC1-SRBK20 Chemical Senses Individual Pre- and Post-doctoral Fellowships
Review Study Section
Chair, symposium on “Adaptive Evolution of Insect Olfactory Systems,” Association for
Chemoreception Sciences annual meeting, Bonita Springs, FL.
External reviewer for the project “Netherlands Twin Registry Repository: researching
the interplay between genome and environment”, for the Netherlands Organization for
Scientific Research.
Invited symposium speaker, EMBO 2015 meeting, Birmingham, UK, and European
Drosophila Research Conference, Heidelberg, Germany.
NIDCD Fellowship Review- ZDC1-SRB Y53 Study Section.
NIGMS “Maximizing Investigator’s Research Award” (MIRA) R35 Special Emphasis
Panel, ZGM1 TRN-5 (MR).
Featured in “International Innovation (2015, issue 193, pp80-82) - A true barfly:
exploring alcohol sensitivity.”
2016 NIDCD Fellowship Review- ZDC1-SRB Y53 Study Section.
Invited keynote speaker at the National Symposium: Bridging Genomics and
Phenomics, Beijing, China, and visiting scholar at Beijing Forestry University, Beijing,
China.
Workshop on Presentation Skills, Beijing Forestry University, Beijing, China.
Association for Chemoreception Sciences Annual Meeting Strategic Planning
Committee.
2016-2017 NC State University Chancellor’s Circle
2017 NIDCD Chemical Senses Fellowships Review- ZDC1-SRB-K (18) Study Section.
Invited seminar speaker at University of Notre Dame and Clemson University
-21-
Professional Affiliations
1. Society for Neuroscience
2. North Carolina Chapter of the Society for Neuroscience
3. American Association for the Advancement of Science
4. Association for Chemoreception Sciences
5. The Genetics Society of America
6. The International Behavioral and Neural Genetics Society
7. The American Society of Human Genetics
8. American Genetic Association
Teaching responsibilities
1987-1988 Graduate Student Seminar in Physiology (PHY 280) Course Director.
1989-1993 Graduate Student Seminar in Neurobiology (NBI 280) Course Director.
1989-1993 Basic Neurobiology (NBI 202) lectures on “Chemical Senses”.
1988, 1989 Neurobiology of Sensory Systems (PHY 225/ANA 225; NBI 225/CBI 225)
lectures on “Chemical Senses.”
1990, 1991 Systems Neurobiology: Anatomy and Physiology of the Central Nervous
System (NBI 209) lectures on “Chemical Senses.”
1994, 1995 Macromolecular Structure (BCH 601) lectures on “Structure and Function of
Membrane Proteins.”
1995, 1996 Graduate Student Seminar in Biochemistry (BCH 691) Course Director.
1995 BCH 605, lectures on G-proteins and G-protein coupled receptors
1995 Keynote speaker at the College of Veterinary Medicine First Annual Teaching
Effectiveness Workshop (North Carolina State University, Raleigh, NC, August
18, 1995).
1996 Discussion Leader (“communicating effectively in the classroom”) at the College
of Veterinary Medicine Second Annual Teaching Effectiveness Workshop
(North Carolina State University, Raleigh, NC, August 19, 1996)
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1997-2005 &
2007 ZO421 “Principles of Physiology” (undergraduate lecture course)
1997 ZO592N “Sensory Physiology” (graduate course)
1997 Discussion Leader (“Communicating effectively in the classroom”) at the
College of Veterinary Medicine Third Annual Teaching Effectiveness
Workshop (North Carolina State University, Raleigh, NC, November 25, 1997)
1997-2001 Seminars in the Crosstalk series of the NCSU Graduate School on Techniques of
Oral Scientific Presentation.
1999 ZO824D “Sensory Physiology” (graduate course)
2000 Cold Spring Harbor Course, Neurobiology of Drosophila, lectures and lab on
Drosophila olfaction.
2002 Lectures on organization of NIH and techniques of oral scientific presentation in
the biotechnology professional development course.
2004 Summer Institute for Statistical Genetics (North Carolina State University,
Raleigh); Instructor for a three-day module on Behavior Genetics.
European Institute for Statistical Genetics (University of Algarve, Faro, Portugal)
Instructor for a three-day module on Behavior Genetics.
2005, 2007, 2012, 2014,2016 GN820D “Professional Development” (graduate course
taught together with Dr. Trudy Mackay)
2006 Workshop on scientific writing, College of Veterinary Medicine, North Carolina
State University, Raleigh, NC.
2008 Workshop on Oral Scientific Presentation, Department of Wood and Paper
Science, North Carolina State University, Raleigh, NC.
2008 GN495A/ZO592A “Principles of Behavioral Genetics” (taught together with Dr.
Trudy Mackay)
2010 GN810/ZO824 “Principles of Behavioral Genetics” (taught together with Dr.
Trudy Mackay)
2013-2016 Graduate Student Professional Development Workshop, lectures on oral scientific
presentation
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Graduate Students
Grazyna Fedorowicz (M.S.) 1996-1999 Scientist, Veracyte, Inc. San Francisco, CA
Indrani Ganguly (Ph.D.) 1996-2002 Lecturer, University of San Diego, San Diego, CA.
Deepa Sambandan (Ph.D) 2004-2008 Postdoctoral Fellow, National Institute of
Environmental Health Sciences, Research Triangle
Park, NC
Ping Wang (Ph.D.) 2004-2008 Research Scholar, Department of Pathology, Duke
University Medical Center, Durham, NC.
Shanshan Zhou (Ph. D.) 2005-2011 * Postdoctoral Fellow, Department of Biological
Sciences, North Carolina State University, Raleigh,
NC
Shilpa Swarup (Ph.D.) 2007-2011 * Research Scientist, Monsanto, Inc., St. Louis, MO
Yasmin Serrano Negron (M. S.) 2009-2012 Research Technician, National Institute of Heart,
Lung and Blood, Bethesda, MD
Joel Johnstun (doctoral candidate) 2014-present
Sneha Mokashi (doctoral candidate) 2014-present
*Kenneth Keller Award for best doctoral dissertation, College of Agriculture and Life Science
Postdoctoral Fellows
David Snyder 1989-1992 Vice President, Clinical Development and
Regulatory Affairs, Gamida Cell, Ltd, Jerusalem,
Israel
Christa Karavanich Diercksen 1996-2000 Lecturer, Department of Biology, University of
Central Florida, Orlando, FL.
Kennedy Wekesa 1996-2000 Professor of Biology and Dean of the College of
Science, Mathematics and Technology, Alabama
State University, Montgomery, AL
Stephanie Rollmann 2000-2006 Associate Professor, Department of Biological
Sciences, University of Cincinnati, Cincinnati, OH
-24-
Juan José Fanara 1999-2002 Associate Professor, Department of Ecology,
Genetics and Evolution, University of Buenos
Aires, Buenos Aires, Argentina
Mary Anna Carbone 2002-2004 Research Assistant Professor, Department of
Biological Sciences, North Carolina State
University, Raleigh, NC
Tatiana Morozova 2004-2006 Research Scholar, Department of Biological
Sciences, North Carolina State University, Raleigh,
NC
Akihiko Yamamoto 2001-2012 Research Scholar, Department of Biological
Sciences, North Carolina State University, Raleigh,
NC
Allison Weber 2008-2012 Statistical Geneticist, Monsanto Inc., St. Louis, MO
Shanshan Zhou 2011-present
Service on University Committees
1988-1992 Admissions Committee of the Cell and Molecular Biology Program
1989-1992 Admissions Committee, Department of Neurobiology, Graduate Program
1989/1990 Department of Neurobiology Seminar Committee
1991-1992 Admissions Committee for the Medical Scientist Training Program
1991/1992 Faculty Research Seminar Committee
1996-1999 CALS Molecular Genetics Facility Advisory Planning Committee
1996 Department of Zoology Space and Facility Planning Committee
1997-1998 Chair, Department Seminar Committee, Department of Zoology, NCSU
Chair, Cell Biology Faculty Search Committee, Department of Zoology
1997-present Coordinator, Invited Seminars for the W. M. Keck Center for Behavioral Biology
1998-2000 CALS Research Committee
2000-2001 Molecular Genetics Faculty Search Committee, Department of Genetics, NCSU
-25-
2002 Research Ethics Committee
2004-2005 Functional Genomics Admissions Committee
2008 Department of Biology Faculty Search Committee
2013-2014 Organizer of weekly “Friday Connections” faculty interactions series.
2014-present Executive Committee Genetics Program, NCSU
Chair, Seminar Committee, Genetics Program, NCSU
2015 Nominating Committee for the Oscar Fletcher Distinguished Professorship in
Comparative Oncology Genetics
Departmental representative for the recruitment of the Assistant Dean for
Finances and the Assistant Dean for Culture, Talent and Human Resources
2016 Neurobiology Search Committee, College of Veterinary Medicine, NCSU
Neuroscience Steering Committee, College of Veterinary Medicine, NCSU
Previous and current research support
1. NIH New Investigator Research Award R23-NS-24521 (8/1/86-7/31/88) “Primary events
in olfactory reception” $71,000 direct cost, $34,500 indirect cost, 105,500 total cost
2. NIH First Independent Research Support and Transition Award R29-DC00394 (8/1/88-
7/31/92) “Primary events in olfactory reception” $278,478 direct cost, $132,827 indirect
cost, $411,305 total cost.
3. U.S. Army Research Office grant DAAL03-86-K-0130 (8/1/86-7/31/89) “Primary events
in olfactory reception” $148,915 direct cost, $74,459 indirect cost, $223,374 total cost.
4. U.S. Army Research Office grant DAAL03-89-K-0178 (9/30/89-9/29/92) “Primary
events in olfactory reception” $205,652 direct cost, $94,348 indirect cost, $300,000 total
cost.
5. North Carolina Biotechnology Center Grant 87-G-02303 (5/1/87-11/30/88) “Mechanisms
of bitter taste transduction” $24,000 direct cost, $5,000 indirect cost, $29,000 total cost.
6. NATO Collaborative Research Grant CRG-890435 (7/5/89-7/4/91) “Characterization of
odorant-activated ion channels” $6,323 direct cost only to support collaborative research
with Dr. Anna Menini (C.N.R., Genova, Italy).
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7. NIH Program Project Grant 5P01-AG05128 “Steroids in Alzheimer’s Disease” (8/1/90-
4/1/91) $8,320 direct cost to support a pilot study as part of the Alzheimer’s Center’s
Program Project grant (A. Roses, M.D. program director).
8. NSF grant DIR-87-15932 (6/1/89-8/31/90) Instrumentation grant for the acquisition of an
ultracentrifuge $42,000.
9. NIH grant 1S15-HL-44029 (9/1/89-8/31/90) Instrumentation grant for the acquisition of a
Rainin HPLC system (Department of Neurobiology), a stop-flow spectrophotometer
(Department of Biochemistry) and a system to measure muscle contraction (Department
of Cell Biology) $90,722.
10. Co-Principal Investigator on Office of Naval Research Grant N00014-87-K-0544 to Dr.
Sidney A. Simon “Functional reconstitution of the olfactory membrane (4/1/87-9/30/90)
$206,639 direct cost, $93,158 indirect cost, $299,797 total cost.
11. Co-Principal Investigator on a grant form the Nutrasweet Company to Dr. Susan S.
Schiffman “Molecular physiology of gustation” (7/13/88-8/14/90) $61,420 direct cost,
$15,355 indirect cost, $76,775 total cost.
12. NIH grant 2R55-DC00394 “Transduction-excitation coupling in olfaction” (9/30/92-
9/29/94) $100,000 total cost, $80,000 direct cost, $20,000 indirect cost.
13. U.S. Army Research Office grant DAAL03-92-G-0390, reclassified as DAAH04-94-G-
0027, “Functional characterization of odorant receptors” (9/1/92-12/14/95) $330,451 total
cost, $219,132 direct cost, $111,319 indirect cost.
14. NIH grant 1R01-DC02485 “Molecular genetics of olfaction in Drosophila” (1/1/95-
12/31/97) $550,018 total cost, $376,758 direct cost, $173,260 indirect cost.
15. U.S. Army Research Office grant DAAH04-96-I-0096 “Molecular mechanisms of odor
recognition” (05/01/96-4/30/99) $240,000 total cost, $188,236 direct cost, $51,764
indirect cost.
16. North Carolina Biotechnology Center Academic Research Initiation Grant 9605-ARG-
0015 “Adaptation to reproductive pheromones in the domestic pig: Stimulus-dependent
termination of vomeronasal transduction cascades” (7/1/96-12/31/97) $40,000 DC only.
17. W.M. Keck Foundation grant 981656 “Development of a program for behavioral biology
at North Carolina State University” Proposed duration 5 years, $800,000 total cost,
shared among Drs. R. R. H. Anholt, T. F. C. Mackay, J. G. Vandenbergh, C. Schal and F.
L. Gould.
18. NIH grant R01-GM59469-04 “Molecular genetics of olfaction in Drosophila” (4/1/99-
3/31/03) $1,165,718 total cost, $798,236 direct cost, $367,482 indirect cost.
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19. College of Agriculture and Life Sciences Competitive Research Grant “Characterization
of a novel family of extracellular matrix proteins with olfactomedin homology domains”
(7/1/98-6/30/99) $15,000 total cost.
20. Glaucoma Research Foundation Catalyst Grant “Identification of olfactomedin proteins
that interact with the glaucoma associated TIGR/MYOC protein: Potential effect of their
interaction on outflow facility” (10/01/99-09/30/01; PI, Dr. Teresa Borrás, Duke
University Medical Center) $95,470 total cost (direct cost only), $30,157 share of R.
Anholt.
21. North Carolina Biotechnology Center ARIG Program 2000 “New targets for
biotechnology-driven urban pest control: Identification of cockroach pheromone binding
proteins” (7/1/00 -12/31/01; R. Anholt, PI, C. Schal, Co-PI) $44,500.
22. NIH grant R01-GM59469-08 “Molecular genetics of olfaction in Drosophila” (4/1/03-
3/31/08) $1,314,281 total cost, $900,000 direct cost, $414,281 indirect cost.
23. NIH grant R01-EY015873 “Comparative genomics of glaucoma” (4/1/05 - 3/31/10)
$2,008,973 total cost, 1,390,952 direct cost, $618,021 indirect cost (subcontract with the
University of North Carolina at Chapel Hill).
24. NIH grant R21-AA015348 “Genetics of alcohol sensitivity in Drosophila” (12/01/04-
11/30/06) $401,500 total costs, $275,000 direct costs, $126,500 indirect costs. PI, Dr.
Trudy F. C. Mackay.
25. NIH grant R03-TW007070 “Molecular genetics of olfaction in Drosophila” (07/01/05-
6/30/08) $96,000 direct cost, $28,155 indirect cost, $124,155 total cost. This is a Fogarty
International Research Collaboration Award with Dr. Juan-José Fanara at the University
of Buenos Aires, Argentina.
26. UNC Office of the President “Training in Behavioral Genomics” (03/01/05-2/29/08)
$450,000 direct cost only. This is a training grant with five co-investigators for training in
behavioral genomics in the W. M. Keck Center for Behavioral Biology.
27. NIH grant R01-GM076083 “Genetics of aggression in Drosophila” (07/01/06-06/30/10)
$768,000 direct cost, $353,280 indirect cost, $1,121,280 total cost. PI, Dr. Trudy F. C.
Mackay.
28. NIH grant R01-AA016560 “Genetics of alcohol sensitivity in Drosophila” (01/01/07-
12/31/11) $1,125,000 direct cost, $517,500 indirect cost, $1,642,500 total cost. PI, Dr.
Trudy F. C. Mackay.
29. NIH grant R01-GM059469 “Molecular genetics of olfaction in Drosophila” (09/01/08-
3/31/12) $979,618 direct cost, $475,929 indirect cost, $1,455,547 total cost. This grant
was supplemented with a one-year minority stipend supplement to support Yazmin L.
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Serrano Negron and a two-year $320,787 total cost supplement under the American
Recovery and Reinvestment Act.
30. NIH grant R01-GM045146 “QTLs in Drosophila” (07/01/09-06/30/13) $1,400,000 direct
cost, $672,000 indirect cost, $2,072,000 total cost. Multiple PI/PD, Drs. Trudy F. C.
Mackay (contact PI), Eric A Stone, Robert R. H. Anholt. This grant was supplemented
with a 2-year $480,000 supplement under the American Recovery and Reinvestment Act.
31. NIH grant 5RC1ES018255-02 “Oxidative stress and neurogenetic networks in
Drosophila” (09/28/09-09/27/11) $483,276 direct cost, $232,885 indirect cost, $716,161
total cost. Multiple PI/PD, Drs. Robert R. H. Anholt. (contact PI), Trudy F. C. Mackay,
Eric A Stone. This is a challenge grant under the American Recovery and Reinvestment
Act.
32. NIH grant R01-AA016560 “Genetics of alcohol sensitivity in Drosophila” (07/01/12-
06/30/17) $1,625,525 direct cost, $796,505 indirect cost, $2,422,030 total cost. Multiple
PI/PD, Drs. Robert R. H. Anholt. Trudy F. C. Mackay (contact PI).
33. NIH grant R01-GM076083 “Genetics of aggression in Drosophila” (08/01/12-03/31/16)
$834,570 direct cost, $429,800 indirect cost, $1,264,370 total cost. Multiple PI/PD, Drs.
Trudy F. C. Mackay (contact PI), Robert R. H. Anholt, Eric A. Stone.
34. NIH grant R01-GM059469 “Molecular genetics of olfaction in Drosophila” (08/01/13-
07/31/17) $1,174,489 direct cost, $604,862 indirect cost, $1,779,351 total cost. Multiple
PI/PD, Drs. Robert R. H. Anholt (contact PI) and Trudy F. C. Mackay.
35. NIH grant R21-ES021719 “Neurogenetics of lead toxicity in Drosophila” (09/01/13-
08/31/15) $275,000 direct cost, $141,625 indirect cost, $416,625 total cost. Multiple
PI/PD, Drs. Robert R. H. Anholt (contact PI) and Trudy F. C. Mackay.
36. NIH grant R01-AG043490 "Systems genetics of life span in Drosophila" (09/01/13-
08/31/18) $1,250,000 direct cost, $643,750 indirect cost, $1,893,750 total cost. Multiple
PI/PD, Drs. Trudy F. C. Mackay (contact PI) and Robert R. H. Anholt.
Pending grant applications
1. NIH grant 1R01-DC016584-01 “Functional dissection of chemosensory gene clusters in
Drosophila” (09/01/17-08/31/22) total direct cost requested $1,979,716. Multiple PI/PD,
Drs. Robert R. H. Anholt (contact PI) and Trudy F. C. Mackay.
2. NIH grant 1R01-MH114907-01 “Genetics of social modulation of aggression” (09/01/17-
08/31/21) total direct cost requested $1,707,336.
3. NIH grant 1R01-ES028672-01 “Drosophila systems toxicogenomics” (09/01/17-
08/31/22) total direct cost requested $2,424,830. Multiple PI/PD, Drs. Trudy F. C.
Mackay (contact PI) and Robert R. H. Anholt.
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4. NIH grant 1U01-DA045245-01 “Genetics of cocaine and metamphetamine preference”
(10/01/17-09/30/22) total direct cost requested $2,264,525. Multiple PI/PD, Drs. Trudy F.
C. Mackay (contact PI) and Robert R. H. Anholt.
