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Curriculum Vitae
Evelyn Tiffany-Castiglioni
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CURRICULUM VITAE
Evelyn Tiffany-Castiglioni, Ph.D.
December 2014
PRESENT POSITION AND ADDRESS:
Title: Professor and Head
Associate Dean for Undergraduate Education
Office: Department of Veterinary Integrative Biosciences
Phone: (979) 845-2828
FAX: (979) 847-8981
Email: [email protected]
EDUCATION:
Degree/Training Conferring Institution Field Year
BS The University of Texas at El Paso Biology (Highest Honors) 1975
-- The University of Texas at Austin Genetics 1976
PhD The University of Texas Medical Human Genetics and Cell 1979
Branch at Galveston Biology
PROFESSIONAL EXPERIENCE AND ACADEMIC APPOINTMENTS
1976-1977 Predoctoral Trainee, Teaching Assistant, University of Texas at Austin
1977-1979 Predoctoral Trainee, Teaching & Research Assistantship, The University
of Texas Medical Branch, Galveston
1980-1982 Postdoctoral Fellow, University of California at Los Angeles
1982 Assistant Professor, Veterinary Anatomy, Texas A&M University
1987- 1994 Associate Professor (tenured), Veterinary Anatomy, Texas A&M
University
1989-1990 Visiting Associate Professor, University of Texas Health Science Center at
San Antonio
1990-Present Faculty of Toxicology (Executive Council), Texas A&M University
1991-Present Faculty of Neuroscience, Texas A&M University
1994-Present Professor, Veterinary Anatomy and Public Health, Texas A&M University
1996-1998 Assistant Dean for Undergraduate Education, College of Veterinary
Medicine, Texas A&M University
1998-Present Associate Dean for Undergraduate Education, College of Veterinary
Medicine, Texas A&M University
1998-1999 Interim Department Head, Veterinary Anatomy and Public Health, Texas
Curriculum Vitae
Evelyn Tiffany-Castiglioni
Page 2
A&M University
1999- Present Department Head, Veterinary Integrative Biosciences (renamed from
Veterinary Anatomy and Public Health), Texas A&M University
AWARDS AND HONORS:
National Merit $1000 Scholarship, 1972
Texas Valedictorian Scholarship, 1972
General Property Scholarship, The University of Texas at El Paso, 1972-1975
Graduation with Highest Honors, The University of Texas at El Paso, 1975
Women's Auxiliary Scholarship, The University of Texas at El Paso, 1975
Welsh Fellowship, The University of Texas, Austin, Texas, Summer 1976
NIH National Research Service Award Predoctoral Traineeship, 1978-1979
Bank of America - Giannini Foundation Medical Research Fellowship, 1980-1982
Outstanding Young Women of America, 1985
Gamma Sigma Delta, 1986
Who's Who in Veterinary Science and Medicine, 1987, 1991
Sigma Xi, 1990
Carrington Award for Research, College of Veterinary Medicine, 1993
TAMU Former Students Association Distinguished Faculty Award for Research, 1998
Phi Kappa Phi, Faculty Member, 1999-present
Golden Key National Honor Society, Faculty Member, 1999-present
2002 Distinguished Alumnus Award, Graduate School of Biomedical Sciences, University of
Texas Medical Branch at Galveston
Who’s Who in America, 2000-2007
Women’s Faculty Network Outstanding Mentoring Award (Texas A&M University), 2012
Women’s Progress Award (Texas A&M University), 2013
TAMU Former Students Association Distinguished Faculty Award for Administration, 2014
EDITORIAL BOARDS:
Neurotoxicology, 1999-2004; Associate Editor, 2004-present
International Journal of Developmental Neuroscience, 2000-present
GRANT REVIEW COMMITTEES:
National Institute of Environmental Health Sciences (Special Emphasis Panel), 1997 Panelist,
National Science Foundation Graduate Research Fellowship Evaluations, 2002, 2003,
2005
National Institute of Occupational Safety and Health (SOH Study Section; ad hoc November
2002, June 2003, November 2003; regular member 2004-2007)
National Institutes of Health, NIA, Special Emphasis Panel ZAA1 CC (03) R, 07/08/2009-
Curriculum Vitae
Evelyn Tiffany-Castiglioni
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07/09/2009
National Science Foundation review panel for Graduate Research Fellowships Program,
Microbiology & Cell Biology Panel, 2009, 2014
NIOSH Disease, Disability and Injury Prevention and Control Special Emphasis Panel ZOH1
EEO (50), teleconference meetings November 15, 2010, June 16, 2011, and March 5,
2013.
Member, Scientific Steering Committee of the International Conference on Alternatives for
Developmental Neurotoxicity Conference, DNT3, Italy, 11-13 May 2011, 2009-2011.
NIOSH SOH Study Section ad hoc member, February 21-23, 2012; February 19-21, 2013,
October 2013, February 2015
NORA Study Section ad hoc member, February 21, 2013, February 20, 2015
NIOSH WTC Study Section ad hoc member, February 21-22, 2013, March 31- April 2, 2014
NIOSH SOH Member Conflict Reviewer, October 28, 2014
TEACHING EXPERIENCE (Last 15 years):
Didatic courses:
Undergraduate Histology course coordinator and sole lecturer (1990-1996), Freshman Seminar
course coordinator (2009-2011), Lecturer in graduate courses in Neuroanatomical Systems,
Toxicology, and Neuroscience (1996-present)
Graduate Students:
Advisor or
Institution
Committee
Name Degree Member Graduation
Date
Clarkson, Christina Rothen Ph.D. (Vet. Anatomy) Advisor May, 1985
Roberts, Julie Ann M.S. (Vet. Anatomy) Advisor Dec., 1986
Wu, Jo-Nan M.S. (Vet. Pub. Health) Comm. Member & Aug., 1986
Major Professor
Rowles, Teresa Kerley Ph.D. (Vet. Anatomy) Advisor May 1989
Sierra, Evelyn Marie Ph.D. (Vet. Anatomy) Advisor May 1991
Legare, Marie E. Ph.D. (Vet. Anatomy) Advisor May 1995
Hanneman, William Ph.D. (Toxicology) Advisor May 1995
Gandhi, Chirag M.S. (Toxicology) Advisor May 1996
Zenger, Elisabeth Ph.D. (Vet. Anatomy) Advisor Aug. 1997
Hong, Sandra Ph.D. (Toxicology) Advisor Aug. 1997
Lindahl, Lora Schneider Ph.D. (Vet. Anatomy) Advisor Dec. 1999
Tang, Yan M.S. (Vet. Anatomy) Advisor Dec. 1999
Curriculum Vitae
Evelyn Tiffany-Castiglioni
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Cho, Tae-Hyuon Ph.D. (Toxicology) Advisor Aug. 2001
Pourrajabi, Nima M.S. (Vet. Anatomy) Advisor Aug. 2003
Yang, Wonsuk Ph.D. (Toxicology) Advisor Dec. 2005
Liu, Xuhong Ph.D. (Toxicology) Co-Advisor Aug. 2005
Jessica Rivera MS NTO (Biomedical Sci) Co-Advisor Dec. 2006
Thuett, Kerry Ph.D. (Toxicology) Co-Advisor Aug. 2009
Tanner, John W. Ph.D. (Animal Science) Comm. Member Aug. 1988
Coleman, Michael M.S. (Animal Science) Comm. Member Aug. 1988
Zevallos, Lisa Ph.D (Genetics) Comm. Member May 1989
Bissey, LeDawn M.S. (Microbiology) Comm. Member Aug. 1989
Loskatoff, Nadia Ph.D. (Vet. Physiology) Comm. Member Dec. 1989
Curtin, Geoffrey Ph.D. (Vet. Anatomy) Comm. Member May 1990
Britt, Janice Ph.D. (Toxicology) Comm. Member May 1990
Stein, Lisa Ph.D. (Vet. Anatomy) Comm. Member May 1990
Gable, Clayton Ph.D. (Exercise Physiology) Comm. Member Aug. 1991
Wofford, Billy Alan Ph.D. (Chemistry) Comm. Member Aug. 1991
Coulter, Kent Ph.D. (Chemistry) Comm. Member Aug. 1992
Hoffman, Anton Ph.D. (Vet. Anatomy) Comm. Member Dec. 1992
Tang, Hsiao-Yuan Ph.D. (Med. Biochem./Gen.) Comm. Member Aug. 1993
Danave, Indrani M.S. (Vet. Pathobiology) Comm. Member Aug. 1993
Schroeder, Matthew Ph.D. (Vet. Anatomy) Comm. Member Dec. 1993
Fuller, David Ph.D. (Vet. Physiology) Comm. Member Dec. 1993
Santostefano, Michael Ph.D. (Toxicology) Comm. Member Aug. 1994
Liu, Hong Ph.D. (Vet. Toxicology) Comm. Member Aug. 1994
Reising, Joseph Ph.D. (Finance) Comm. Member Aug. 1995
Crouch, Elizabeth Merriam Ph.D. (Genetics) Comm. Member May 1996
Dekaney, Christopher Ph.D. (Vet. Anatomy) Comm. Member Aug. 1996
Zhang, Yong Ph.D. (Toxicology) Comm. Member Dec. 1996
Walker, Dana M.S. (Vet. Anatomy & PH) Comm. Member Aug. 1998
Edwards, Michael Ph.D. (Chem. Engineering) Comm. Member Dec. 1998
Lau, Francis Ph.D. (Vet. Anatomy & PH) Comm. Member May 1999
Tennakoon, Deepani Ph.D. (Vet. Anatomy & PH) Comm. Member Dec. 1999
Tipton, Tiffani M.S. (Nutrition) Comm. Member Dec. 2000
Giancristoforo-Calvi, F. Ph.D. (Anthropology) Comm. Member Aug. 2000
Rhymer, Dawn Ph.D. (Chem. Engineering) Comm. Member Dec. 2000
Szabo, Theresa Ph.D. (Zoology) Comm. Member Dec. 2001
Majumdar, Sudeep Ph.D. (Nutrition) Comm. Member May 2002
Jiang, Jing M.S. (Med. Pharm. & Tox.) Comm. Member Aug. 2003
Nayak, Mamantha Ph.D. (Microbiology) Comm. Member Dec. 2003
Nahm, Sangsop Ph.D. (Vet. Anatomy) Comm. Member Aug. 2003
Frank, Tamy Ph.D. (Vet. Anatomy) Comm. Member Dec. 2005
Reeves, Tony Ph.D. (Med. Physiology) Comm. Member May 2006
Curriculum Vitae
Evelyn Tiffany-Castiglioni
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Dheepa Braumbhatt M.S. (BIMS, non-thesis) Comm. Member May 2011
Clendenin, Angela Ph.D. (Biomedical Sciences) Comm. Member In progress
Huang, Chia-Yu Ph.D. (Biomedical Sciences) Comm. Member In progress
Persky, Laura M.S. (non-thesis, V. Anat.) Comm. Member May 2006
Kajen, Payam M.S. (non-thesis, BIMS) Chair Aug. 2013
Ahn, Thomas M.S. (non-thesis, BIMS) Chair May 2014
Aninye, Rashad M.S. (non-thesis, BIMS) Chair Dec. 2014
Sarker, Borna M.S. (non-thesis, BIMS) Chair In progress
Bui, Jasmin M.S. (non-thesis, BIMS) Chair In progress
Theses and Dissertations Supervised as Major Professor Clarkson, Christina Rothen, DVM - Tissue culture as a means of establishing an epidermal-
implant union in percutaneous implants. Ph.D. (Veterinary Anatomy), May 1985.
Roberts, Julie Ann - The effect of iron chloride and glutamate on glutamine synthetase activity in
primary cultured rat cortical astrocytes: a model for epileptic induction. M.S. (Veterinary
Anatomy), December 1986.
Wu, Jo-Nan - Cytotoxicity of lead on oligodendroglia, astroglia, and meningeal fibroblasts in
culture: effects on viability and glycerophosphate dehydrogenase activity. M.S.
(Veterinary Public Health), August 1986. (Committee chair: Gary N. Joiner; Major
Professor: Evelyn Tiffany-Castilgioni)
Rowles, Teresa Kerley, DVM - Lead neurotoxicity: in vitro and in vivo effects. Ph.D.
(Veterinary Anatomy), May 1989.
Sierra, Evelyn Marie - A guinea pig model for low-level lead toxicity during gestation. Ph.D.
(Veterinary Anatomy), May 1991.
Marie E. Legare, DVM - Lead toxicity in astroglia. Ph.D. (Veterinary Anatomy & Public
Health), May 1995.
William Hanneman - Cellular fingerprinting of 2,3,7,8-Tetrachlorodibenzo-para-dioxin as a
neurotoxicant. Ph.D. (Toxicology), May 1995.
Chirag Gandhi - Test systems to assess the detoxification of organophosphate chemicals by
organophosphate hydrolase. M.S. (Toxicology), May 1996. (Co-Chair of Committee
with KC Donnelly)
Elisabeth Zenger, DVM - Characterization of astroglial dysfunction following feline
immunodeficiency viral infection. Ph.D. (Veterinary Anatomy & Public Health), August
1997.
Sandra Hong - Biological systems for investigating the neuroactivity of halogenated aromatic
hydrocarbons. Ph.D. (Toxicology), August 1997.
Lora Schneider Lindahl, DVM - An Initial Evaluation of the Relationship Between Lead and
Glutathione in Cultured Astroglia. Ph.D. (Veterinary Anatomy & Public Health),
December 1999.
Yan Tang, MD - Development of in vitro screen assays for potentially neurotoxic PAHs in C6
and SY5Y cells. Ph.D. (Veterinary Anatomy & Public Health), December 1999.
Cho, Tae-Hyuon - Bioremediation of organophosphorus neurotoxicity and genotoxicity in vitro
Curriculum Vitae
Evelyn Tiffany-Castiglioni
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by organophosphorus hydrolase. Ph.D. (Toxicology), August 2001.
Pourrajabi, Nima – Blockage of IL-6 secretion in glia by lead and mercury. M.S. (Veterinary
Anatomy), August 2003.
Xuhong Liu, MD (coadvisor with Ronald Tjalkens) - Astrocyte-derived nitric oxide manganese
neurotoxicity: from cellular and molecular mechanisms underlying selective neuronal
vulnerability in the basal ganglia to potential neurodegenerative disease. Ph.D.
(Toxicology), August 2005.
Wonsuk Yang - The bipyridil herbicide paraquat-induced toxicity in human neuroblastoma SH-
SY5Y cells: relevance to dopaminergic pathogensis. Ph.D. (Toxicology), December
2005.
Kerry Thuett (co-advisor with Louise Abbott) – Comparative neurotoxicity of methylmercury
and mercuric chloride in vivo and in vitro. Ph.D. (Toxicology), August 2009.
Awards Won by Graduate Students Supervised Evelyn M. Sierra
1. Best Student Presentation, Tissue Culture Association, Texas Chapter, Annual
Meeting, Houston, Texas, April 1989
Marie E. Legare
1. Student Poster Competition Award, First Place, TAMU Neuroscience Society,
November 1991
2. Student Poster Competition Award, First Place (tie), Ninth International
Neurotoxicology Conference, Little Rock, Arkansas, October 1991
3. Student Poster Competition Award, First Place, TAMU Neuroscience Society,
November 1992
4. Physician Scientist Award, The National Institutes of Health - “Low-Level Lead
Effects in Glial/Endothelial Co-Cultures,” $523,215; 1992-1997
5. Sigma Xi Research Award, local chapter - “Brain Microvascular Endothelial and
Astroglial Interactions in Response to Low-Level Pb2+
,” $375; 1992
6. Sigma Xi Outstanding New Member Award, local chapter, 1993
7. Sigma Xi Research Award, local chapter - “Radiolabeled Pb2+
Transport in
Astroglia,” $450; 1993
8. Distinguished Graduate Student Award for Doctoral Research, The Association of
Former Students, Texas A&M University, 1995 (one of six awarded University-
wide)
William H. Hanneman
1. Texas A&M University Minigrant, 1993, $500
2. Student Platform Presentation Competition, First Place Reynolds Award), Gulf
Coast Society of Toxicologists Annual Meeting, Galveston, Texas, November
1993
Lora A. Schneider Lindahl
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Evelyn Tiffany-Castiglioni
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1. Physician Scientist Award, The National Institutes of Health - “A Study of Low-
level Lead Toxicity and Glutathione,” $317,510; 1993-1998
2. Student Research Week Texas A&M University, Platform Presentation, First
Place in Biomedical Sciences Graduate Category, March 1999
3. Student Poster Competition Award, Third Place, Seventeenth International
Neurotoxicology Conference, Little Rock, Arkansas, October 1999
4. Distinguished Graduate Student Award for Doctoral Research, the Association of
Former Students, Texas A&M University, 2000 (one of six awarded University-
wide)
Sandra Hong
1. Student Platform Presentation Competition, Honorable Mention, Gulf Coast
Society of Toxicologists Annual Meeting, Galveston, Texas, November 1993
2. Student Poster Competition Award, First Place (Robert Joy Student Award),
Thirteen International Neurotoxicology Conference, Hot Springs, Arkansas,
October 1995
Elisabeth Zenger
1. Physician Scientist Award, The National Institutes of Health - “FIV Infection of
Astroglia: A Model for CNS AIDS,” $337,899, 1993-1998
2. Smith Kline Beecham Distinguished Research Award, “Feline immunodeficiency
virus-induced injury of astroglia examined via vital fluorescence assays,”
American College of Veterinary Internal Medicine, 1994
3. Texas A&M Phi Zeta Chapter Award for Outstanding Research Manuscript, 1995
4. National Phi Zeta Award for Outstanding Research Manuscript, “Laser
Cytometric Analysis of FIV-Induced Injury in Astroglia,” 1995
5. AVMA Council on Research Excellence in Feline Research Award sponsored by
the Winn Feline Foundation, 1996
6. Distinguished Graduate Student Award for Doctoral Research, The Association of
Former Students, Texas A&M University, 1998 (one of six awarded University-
wide)
Tae Cho
1. 1st lace, oral division, 6
th Annual Toxicology Graduate Student Forum, August
1998.
Wonsuk Yang
1. 1st Place poster presentation, Annual College of Veterinary Medicine Graduate
Student Association Research Symposium, April 26, 2005.
TEACHING PROGRAMS:
Kodachrome slide set “Basic Histology,” set of 301 slides and 216 page workbook for use in
Curriculum Vitae
Evelyn Tiffany-Castiglioni
Page 8
VTAN 305. Located in Biomedical Learning Resources Center, A-T Lab. Funded by
Center for Teaching Excellence Incentive Grant, 1984-1985.
Kodachrome slide set of 37 slides and 2 page script for use in VTAN 640 Neurobiology.
Located in Biomedical Learning Resources Center, A-T Lab. 1987.
CD-ROM “Basic Histology,” set over 300 slides with figure legends, practice quizzes, and
explanatory material for use in VAPH 343. Also under modification by Dr. Louise
Abbott for use in VAPH 911. 2000.
RESEARCH/SCHOLARLY ACTIVITIES:
Previous Research Funding Differentiation Antigens of the Glial Cell Surface. Bank of America - Giannini Medical
Research Fellowship, 1980-1982. Principal Investigator.
Morphologic and Metabolic Responses of Astrocytes in Culture to Epileptic Agents. ORR-6-83,
$2,540. Principal Investigator.
Morphologic and Metabolic Responses of Astrocytes in Culture to Epileptogenic Agents.
Epilepsy Foundation of America, 1983-1984, $15,000. Principal Investigator.
Morphologic and Metabolic Responses of Astrocytes in Culture to Epileptogenic Agents.
BRSG-2-83. $3,098. Principal Investigator.
Lead Toxicity in Isolated Oligodendrocyte and Astrocyte Cultures from Rat and Bovine Brain.
Formula Animal Health Funding, Project 6652, 1982-1985, $32,000. Principal
Investigator.
Ontogeny of Oligodendroglia: Identification of Precursors of Oligodendroblasts in Cell Culture.
ORR-1-84, $2,493. Principal Investigator.
Tissue Culture as a Means of Establishing an Epidermal-Implant Union in Percutaneous
Implants. ORR-3-84, $2,500. Co-investigator.
An In Vitro Study of the Invasive Properties of Syncytial Trophoblasts. ORR-17-84, $2,000.
Co-Principal Investigator.
Location of Lead in Lead-treated Astrocyte Cultures from Mature and Immature Cerebrum.
BRSG-4-84, $2,427. Co-investigator.
In Vitro Model for Evaluation Astroglial Protection of Brain Parenchyma from Neurotoxins.
BRSG-8-84, $2,500. Principal Investigator.
Reactive Astroglia in Focal Epilepsy: Cell Culture Model. ORR-14-84, $2400. Principal
Investigator.
Potassium Spatial Buffering by Perivascular Astroglia: Cell Culture Model. BRSG-7-85,
$2654. Principal Investigator.
Astroglial Reaction to an Epileptogenic Iron Compound. American Heart Association, National
Center, 1985-1991, $180,000 (direct costs). Principal Investigator.
Morphologic and Metabolic Effects of Lead on Astrocytes in Culture. Environmental Protection
Agency, 1985-1989, $156,000 (direct costs). Principal Investigator.
Morphometry of ATPase Sites in Astroglia Cultured on Artificial Capillaries. ORR-2-85,
$3,108. Co-Principal Investigator.
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Evelyn Tiffany-Castiglioni
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Seizure-Related Enzymes in Astrocytes in Culture. NIH, NINCDS (NIRA), 1985-1989,
$107,500 (direct costs). Principal Investigator.
Development of a Guinea Pig Model for Lead Neurotoxicity and Growth Inhibition in Children.
Center for Energy and Mineral Resources, Texas A&M University, 1986-1988, $23,595.
Principal Investigator.
Glial Enzyme Markers in Aged Rats on Normal and Caloric Restricted Diets. Alzheimer's
Disease and Related Disorders Association, Inc., 1988-1989, $20,000. Principal
Investigator.
Immunocytochemical Identification of Metabolic Changes in Neurons and Glia During
Epileptogenesis. College of Veterinary Medicine Enhancement Funding, 1990-1991,
$20,000. J.R. Clements, E. Tiffany-Castiglioni, and S.L. Peterson, Co-Principal
Investigators.
Teratogenic Mechanisms of Cache Valley Virus. College of Veterinary Medicine Enhancement
Funding, 1990-1992, $71,000. E.W. Collisson, Principal Investigator. E. Tiffany-
Castiglioni, R. Burghardt, J.F. Edwards, S-I Chung, Investigators.
Interaction of Transferrin and Heavy Metals in Astroglia. BRSG, 1990-1991, $3,000. Principal
Investigator.
Metabolic Changes in Neurons and Glia during Epileptogenesis: An Immunocytochemical
Comparison Between Juvenile and Adult Rats. Epilepsy Foundation of America, 1992-
1993, $30,000. Jane R. Clements, PI, E. Tiffany-Castiglioni and S. Peterson, Co-
Principal Investigators.
Effects of Maternal and Paternal Low-level Lead Exposure on Glial Cell Function. International
Lead and Zinc Research Organization, Inc. RF-91-983, 1992-1994, $209,788. Principal
Investigator.
Placental Transfer of Copper, Iron, and Zinc. NIH (R01) , 1992-1995, $420,000. Edward D.
Harris, Principal Investigator, E. Tiffany-Castiglioni, Co-Principal Investigator.
Low-level Lead Metabolism and Toxicity in Glial Cultures. NIH (R01), 1993-1997, $634,146.
Principal Investigator.
Low-level Lead Effects in Glial/Endothelial Co-cultures. NIH, Physician Scientist Award, 1992-
1997, $523,215. Marie Legare, Principal Investigator, E. Tiffany-Castiglioni, sponsor.
FIV Infection of Astroglia: A Model for CNS AIDS. NIH, Physician Scientist Award, 1993-
1998, $337,899, Elisabeth Zenger, Principal Investigator, E. Tiffany Castiglioni, Co-
sponsor.
A study of Low-level Lead Toxicity and Glutathione. NIH, Physician Scientist Award, 1993-
1998, $317,510. Lora Schneider, Principal Investigator, E. Tiffany-Castiglioni, sponsor.
Developmental Effects of Lead on Synaptogenesis. CVM Enhancement Program, 1996-1997,
$27,331. Principal Investigator.
Copper Transport Across the Blood Brain Barrier. Interdisciplinary Research Initiatives
Program. 1996-1997. $15,974. E.D. Harris, Principal Investigator, E. Tiffany-
Castiglioni, Co-Principal Investigator.
Production of a Polyclonal Antibody to the Menkes Protein. Faculty Mini-Grant. 1997-1998.
$1,500. Principal Investigator.
Curriculum Vitae
Evelyn Tiffany-Castiglioni
Page 10
Pilot Project: Organophosphate Effects on Neuronal Differentiation. NIEHS- Center for
Environmental Rural Health Pilot Project, 7/1/99 - 3/31/00, $17,400. Principal
Investigator.
Effects of Organophosphates on neuronal Molecular Differentiation. Alternative Research
Development Foundation, 8/1/99 - 7/31/00, $20,000. Tiffany-Castiglioni, E., Principal
Investigator, L.C. Abbott, Co-Investigator.
Optimization of Risk Assessment Procedures for Complex Mixtures. DHHS-PHS-Centers for
Disease Control, 1997-2002, $400,000 (approx.) U61/ATU6845-5-01. K.C. Donnelly,
Principal Investigator. E. Tiffany-Castiglioni, Co-Principal Investigator.
Toxicology of Environmental Contaminants, NIEHS, 7/1/02-6/30/07, $757,975. Training Grant
T32-ES07273. Stephen Safe, Principal Investigator. E. Tiffany-Castiglioni, Co-
Investigator and seminar coordinator.
Environmental Toxicology and Rural Health. NIEHS Center Grant P30 ES09106, 5/1/01 -
4/31/07, $400,000. Kenneth Ramos, Principal Investigator, Evelyn Tiffany-Castiglioni,
Investigator.
Procedures to Assess the Hazards of a Superfund Site (NIH). 04/01/00 - 03/31/05, $8,772,842.
NIEHS P42 ES04917. Stephen Safe, Principal Investigator. Project 3: Stress Gene
Induction in Mammalian Cells, Kenneth Ramos, Principal Investigator; E. Tiffany-
Castiglioni, Co-Investigator, $700,000, approximately.
Oral Exposure to Wildlife of Metals in Contaminated Soils. Subcontract through Exponent from
Strategic Environmental Research Development Program (SERDP). 2001-2002,
$113,655. E. Tiffany-Castiglioni, Principal Investigator.
Activated Organophosphorus Hydrolase for Coupling to Human Skin. Batelle Memorial
Institute/Lynntech, Inc. 2002-2003. Jim Wild, Principal Investigator; E. Tiffany-
Castiglioni, Co-Investigator, $40,000 (Tiffany-Castiglioni’s portion).
The Function of Neurofibromin in Astrocytes. Department of Defense Neurofibromatosis
Research Program, Congressionally Directed Medical Research Programs (CDMRP).
2004-2005, $100,000. E. Tiffany-Castiglioni, Principal Investigator.
Early Toxicity Screening for Drug Development in Immature Neural Cells. Colgate-Palmolive
Grants for Alternative Research, 2005-2006, $39,326. R. Mouneimne, Principal
Investigator, E. Tiffany-Castiglioni, Co-Principal Investigator.
Challenge Scholarships for Biomedical Science, Greater Texas Foundation, 2008-2009, $25,000,
Principal Investigator.
BIBLIOGRAPHY:
Publications in Refereed Journals:
Perez-Polo, J.R., K. Werrbach-Perez, E. Tiffany-Castiglioni. 1979. A human clonal cell line
model of differentiating neurons. Develop. Biol. 71:341-355.
Tiffany-Castiglioni, E., J.R. Perez-Polo. 1979. The role of nerve growth factor in vitro in cell
resistance to 6-hydroxydopamine toxicity. Exp. Cell Res. 121:179-189.
Tiffany-Castiglioni, E., J.R. Perez-Polo. 1980. Evaluation of methods for determining 6-
Curriculum Vitae
Evelyn Tiffany-Castiglioni
Page 11
hydroxydopamine cytotoxicity. In Vitro 16:591-599.
Tiffany-Castiglioni, E., J.R. Perez-Polo. 1981. Stimulation of resistance to 6-hydroxydopamine
in a human neuroblastoma cell line by nerve growth factor. Neurosci. Lett. 26:157-161.
Tiffany-Castiglioni, E., R. Saneto, P.H. Proctor, J.R. Perez-Polo. 1982. Participation of active
oxygen species in 6-hydroxydopamine toxicity to a human neuroblastoma cell line.
Biochem. Pharm. 31:181-188.
Peng, W.W., J.P. Bressler, E. Tiffany-Castiglioni, J. de Vellis. 1982. Development of a
monoclonal antibody against a tumor- associated antigen. Science 215:1102-1104.
Perez-Polo, J.R., E. Tiffany-Castiglioni, M. Ziegler, K. Werrbach-Perez. 1982. Effect of nerve
growth factor on catecholamine metabolism in a human neuroblastoma clone (SY5Y).
Develop. Neurochem. 5:418-423.
Bratton, G.R., M. Childress, J. Zmudzki, C. Womac, L.D. Rowe, E. Tiffany-Castiglioni. 1986.
Delta-aminolevulinic acid dehydratase (E.C. 4.3.1.24) activity in erythrocytes from cattle
administered low concentrations of lead acetate. Am. J. Vet. Res. 47:2068-2074.
Tiffany-Castiglioni, E., K.F. Neck, T. Caceci. 1986. Glial culture on artificial capillaries:
Electron microscopic comparison of C6 rat glioma cells and rat astroglia. J. Neurosci.
Res. 16:387-396.
Tiffany-Castiglioni, E., J. Zmudzki, G.R. Bratton. 1986. Cellular targets of lead neurotoxicity:
In vitro models. Toxicology 42:303- 315.
Tiffany-Castiglioni, E., J. Zmudzki, J.-N. Wu, G.R. Bratton. 1987. Effects of lead treatment on
intracellular Cu and Fe in cultured astroglia. Met. Brain Disease 2:61-79.
Wu, J.-N., E. Tiffany-Castiglioni. 1987. Reduction by lead of hydrocortisone-induced glycerol
phosphate dehydrogenase activity in cultured rat oligodendroglia. In Vitro Dev. Cell.
Biol. 23:765- 774.
Tiffany-Castiglioni, E., D. Garcia, J.-N. Wu, J. Zmudzki, G.R. Bratton. 1988. Effects of lead on
viability, and intracellular metal content of C6 rat glioma cells. J. Toxicol. Environ.
Health. 23:267-279.
Rowles, T.K., C. Womac, G.R. Bratton, E. Tiffany-Castiglioni. 1989. Interaction of lead and
zinc in cultured astroglia. Met. Brain Disease. 4:187-201.
Sierra, E., E. Tiffany-Castiglioni. 1989. Low level lead neurotoxicity in a pregnant guinea pig
model: Neuroglial enzyme activities and brain trace metal concentrations. Toxicology
59:81-96.
Tiffany-Castiglioni, E., E.M. Sierra, J.-N. Wu, T.K. Rowles. 1989. Lead toxicity in neuroglia.
NeuroToxicology 10:383-410. (Refereed review)
Tiffany-Castiglioni, E., L.V. Sheeler-Gough, J.A. Roberts. 1990. Reduction of glutamine
synthetase activity by ferrous chloride in cultured astroglia. J. Neurosci. Res. 24:508-
516.
Tiffany-Castiglioni, E., S.L. Peterson, A.J. Castiglioni. 1990. Altered glutamine synthetase
activity in two experimental models of epilepsy. J. Neurosci. Res. 25:223-228.
Castiglioni, A.J., S.L. Peterson, E.L. Sanabria, E. Tiffany- Castiglioni. 1990. Structural changes
in astrocytes induced by seizures in an animal model of temporal lobe epilepsy. J.
Neurosci. Res. 26:334-341.
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Evelyn Tiffany-Castiglioni
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Fischbach, K., Y. Lu, E. Tiffany-Castiglioni, A. Minter, B.H. Bowman, G.S. Adrian. 1990.
Expression of chimeric human transferrin genes in vitro. J. Neurosci. Res. 27(4):633-641.
Sierra, E.M., E. Tiffany-Castiglioni. 1991. Reduction of glutamine synthetase activity in
astroglia exposed in culture to low levels of inorganic lead. Toxicology 65:295-304.
Castiglioni, A.J., M.E. Legare, D.L. Busbee, E. Tiffany-Castiglioni. 1991. Morphological
changes in astrocytes of aging mice fed normal or caloric restricted diets. Age 14:102-
106.
Sierra, E.M., E. Tiffany-Castiglioni. 1992. Effects of low-level lead exposure on hypothalamic
hormones and serum progesterone levels in pregnant guinea pigs. Toxicology 72:89-97.
Legare, M.E., A.J. Castiglioni, Jr., T.K. Rowles, J.A. Calvin, C. Snyder-Armstead, E. Tiffany-
Castiglioni. 1993. Morphological alterations of neurons and astrocytes in guinea pigs
exposed to low levels of inorganic lead. NeuroToxicology 14(1):77-80.
Legare, M.E., R. Barhoumi, R.C. Burghardt, E. Tiffany-Castiglioni. 1993. Low-level lead
exposure in cultured astroglia: Identification of cellular targets with vital fluorescent
probes. NeuroToxicology 14:267-272.
Illanes,O., E.Tiffany-Castiglioni, J.F. Edwards, J.A. Shadduck. 1993. Spontaneous encephaloid
zoonosis in an experimental group of guinea pigs. J. Vet. Diagn. Invest. 5:649-651.
Tiffany-Castiglioni, E. 1993. Cell culture models for lead toxicity in neuronal and glial.
NeuroToxicology 14:513-536. (Refereed review)
Danave, I.R., E. Tiffany-Castiglioni, E. Zenger, R. Barhoumi, R.C. Burghardt, E.W. Collisson.
1994. Feline immunodeficiency virus decreases cell-cell communication and
mitochondrial membrane potential. J. Virology 68:6745-6750.
Zenger, E., E.W. Collisson, R. Barhoumi, R.C. Burghardt, I.R. Danave, E. Tiffany-Castiglioni.
1995. Laser cytometric analysis of FIV-induced injury in astroglia. Glia 13:92-100.
Qian, Y., E. Tiffany-Castiglioni, E.D. Harris. 1995. Copper transport and kinetics in cultured
C6 rat glioma cells. Am. J. Physiology 38:C892-898.
Qian, Y., E. Tiffany-Castiglioni, E.D. Harris. 1996. Functional analysis of a genetic defect of
copper transport (Menkes disease) in different cell lines. Am. J. Physiology 40:C378-
C384.
Hanneman, W.H., M.E. Legare, R. Barhoumi, R.C. Burghardt, S. Safe, E. Tiffany-Castiglioni.
1996. Stimulation of calcium uptake in cultured rat hippocampal neurons by 2,3,7,8-
tetrachlorodibenzo-p-dioxin. Toxicology 112:19-28.
Legare, M.E., W. Hannemann, R. Barhoumi, R.C. Burghardt, E. Tiffany-Castiglioni. 1997. The
effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure in primary rat astroglia:
identification of biochemical targets. Neurotoxicology 18:515-524.
Qian, Y., E. Tiffany-Castiglioni, E.D. Harris. 1997. A Menkes P-type ATPase involved in
copper homeostasis in the central nervous system of the rat. Mol. Brain Res. 48:60-66.
Zenger, E., E. Tiffany-Castiglioni, E.W. Collisson. 1997. Cellular mechanisms of feline
immunodeficiency virus (FIV)-induced neuropathogenesis. Frontiers in Science.
Published on the World Wide Web (http://vega.crbm.cnrs-
mop.fr/bioscience/1997/v2/d/zenger/4.htm).
Hong, S.J., C.A. Grover, S.H. Safe, E. Tiffany-Castiglioni, G.D. Frye. 1998. Halogenated
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Evelyn Tiffany-Castiglioni
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aromatic hydrocarbons inhibit CA1 field excitatory post-synaptic potentials in rat
hippocampal slices. Toxicol. Appl. Pharmacol 148:7-13.
Tiffany-Castiglioni, E. 1998. Astroglia in metal metabolism and toxicity: Commentary on a
forum paper. NeuroToxicology 19:19-22. (Commentary)
Harris, E.D., Y. Qian, E. Tiffany-Castiglioni, A. Lacy, M.C.M. Reddy. 1998. A functional
analysis of copper homeostasis in cell culture models: A new perspective on internal
copper transport. Am. J. Clinical Nutrition 67:988S-995S.
Qian, Y., E. Tiffany-Castiglioni, E.D. Harris. 1998. Sequence of a Menkes-type Cu-transporting
ATPase from rat C6 glioma cells: Comparison of the rat protein with other mammalian
Cu-transporting ATPases. Molecular and Cellular Biochemistry, 181:49-61.
Qian, Y., E. Tiffany-Castiglioni, C.J. Welsh, E.D. Harris. 1998. Copper efflux from murine
microvascular cells requires expression of the Menkes Disease Cu-ATPase. J. Nutrition,
128:1276-1282.
Legare, M.E., R. Barhoumi, E. Hebert, G.R. Bratton, R.C. Burghardt, E. Tiffany-Castiglioni.
1998. Analysis of Pb2+
entry into cultured astroglia. Toxicological Sciences, 46:90-100.
Qian, Y., G. Mikeska, E.D. Harris, E. Tiffany-Castiglioni. 1999. Effect of lead exposure and
accumulation on copper homeostasis in cultured C6 rat glioma cells. Toxicol. Appl.
Pharmacol., 138:41-49.
Lindahl, L.S., L. Bird, M.E. Legare, G. Mikeska, G.R. Bratton, E. Tiffany-Castiglioni. 1999.
Differential ability of astroglia and neuronal cells to accumulate lead: Dependence on
cell type and on degree of differentiation. Toxicol. Sci., 50:236-243.
Tiffany-Castiglioni, E., M. Ehrich, L. Dees, L.G. Costa, P.R.S. Kodavanti, S.M. Lasley, M.
Oortgiesen, H.D. Durham. 1999. Bridging the gap between in vitro and in vivo models
for neurotoxicology. Toxicol. Sci., 51:178-183.
Tiffany-Castiglioni, E. and L. Lindahl. 1999. Complementarity and usefulness of in vitro
approaches in lead toxicology: Commentary on a Forum position paper.
Neurotoxicology, 20:713-718. (Commentary)
Harris E.D., M.C. Reddy, Y. Qian, E. Tiffany-Castiglioni, S. Majumdar, J. Nelson. 1999.
Multiple forms of the Menkes Cu-ATPase. Adv. Exper. Med. Biol. 448:39-51.
Qian, Y, ED Harris, Y Zheng, E Tiffany-Castiglioni. 2000. Lead (Pb) targets GRP78, a
molecular chaperone, in C6 rat glioma cells. Toxicol. Appl. Pharmacol. 163:260-266.
Legare, M.E., W.H. Hanneman, R. Barhoumi, R.C. Burghardt, E. Tiffany-Castiglioni. 2000.
The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on gap junctional communication of
cultured hippocampal neurons and astroglia. Neurotoxicology, 21:1109-1116.
Qian, Y, M.H. Falahatpisheh, Y. Zheng, K. Ramos, E. Tiffany-Castiglioni. 2001. Expression of
78kD glucose regulated protein (GRP78) in lead (Pb) and mercury (Hg) exposed C6 rat
glioma cells. Neurotoxicologic Research, 3:581-589.
Tiffany-Castiglioni, E., Y. Qian. 2001. Astroglia As Metal Depots: Molecular mechanisms for
metal accumulation, storage and release. Neurotoxicology, 22:577-592.
Tiffany-Castiglioni, E., C. Guerri, M. Aschner, G.K. Matsushima, J.P. O’Callaghan, W.J. Streit.
2001. Roles of glia in developmental neurotoxicity: Session VI Summary and Research
Needs. Neurotoxiocology, 22:567-573.
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Evelyn Tiffany-Castiglioni
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Qian, Y., E. Tiffany-Castiglioni. 2003. Lead-induced endoplasmic reticulum (ER) stress
responses in the nervous system. Neurochemical Research, 28:153-162.
Hong, M.S., S.J. Hong, R. Barhoumi, R.C. Burghardt, K. C. Donnelly, J. R. Wild, V. Venkatraj,
E. Tiffany-Castiglioni. 2003. Neurotoxicity induced in differentiated SK-N-SH-SY5Y
human neuroblastoma cells by organophosphorus compounds. Toxicol. Appl.
Pharmacol., 186:110-118.
Tang, Y., K. C. Donnelly, M. G. Mumtaz, E. Tiffany-Castiglioni. 2003. Neurotoxicity of
polycyclic aromatic hydrocarbons and simple chemical mixtures. J. Tox. Env. Health,
66:919-940.
Cho, T.M., E. Tiffany-Castiglioni. 2004. Neurofilament 200 as an indicator of differences
between mipafox and paraoxon sensitivity in SY5Y neuroblastoma cells. J. Tox. Env.
Health, 67:987-1000.
Donnelly, K.C., R. Lingenfelter, L. Cizmas, M.H. Falahatpisheh, Y. Qian, Y. Tang, S. Garcia, K.
Ramos, E. Tiffany-Castiglioni, M.G. Mumtaz. 2004. Toxicity assessment of complex
mixtures remains a goal. Env. Toxicol. Pharmacol 18:135–141.
Qian, Y., E. Tiffany-Castiglioni. 2005. GRP78 compartmentalized redistribution in Pb-treated
glia: role of GRP78 in lead-induced oxidative stress. Neurotoxicology 26:267-75.
Qian, Y., Y. Zheng, L. Abraham, K. S. Ramos, E. Tiffany-Castiglioni. 2005. Differential
profiles of copper-induced ROS generation in human neuroblastoma and astrocytoma
cells. Mol. Brain Res. 134:323-332.
Qian, Y., Y. Zheng, K. S. Ramos, E. Tiffany-Castiglioni. 2005. The involvement of copper
transporter in lead-induced oxidative stress in astroglia. Neurochemical Research
30:429-438.
Tiffany-Castiglioni, E., J.S. Venkatraj, Y. Qian. 2005. Genetic polymorphisms and mechanisms
of neurotoxicity: overview. Neurotoxicology 26:641-649.
Yang, W., E. Tiffany-Castiglioni. 2005. The bipyridyl herbicide paraquat produces oxidative
stress-mediated toxicity in human neuroblastoma SH-SY5Y cells: relevance to the
dopaminergic pathogenesis. J.Tox. Env. Health 68:1939-1961.
Harry, G. J., E. Tiffany-Castiglioni. 2005. Evaluation of neurotoxic potential by use of in vitro
systems. Expert Opin. Drug Metab. Toxicol. 1(4):1-13.
Cho, T.M., J. R. Wild, K.C. Donnelly, E. Tiffany-Castiglioni. 2006. Remediation of
organophosphorus neurotoxicity in SY5Y neuroblastoma cells by organophosphorus
hydrolase (OPH). J. Tox. Env. Health 69:1413-1429.
Tiffany-Castiglioni, E., S. Hong, Y. Qian, Y. Tang, K.C. Donnelly. 2006. In vitro models for
assessing neurotoxicity of mixtures. Neurotoxicology. 27(5):835-9.
Barhoumi, R., R.C. Burghardt, Y. Qian, E. Tiffany-Castiglioni. 2007. Effects of propofol on
intracellular Ca2+
homeostasis in human astrocytoma cells. Brain Res 1145: 11-8.
Falahatpisheh, H., A. Nanez, D. Montoya-Durango Y. Qian, E. Tiffany-Castiglioni, K.S. Ramos.
2007. Activation profiles of HSPA5 during the glomerular mesangial cell stress response
to chemical injury. Cell Stress Chaperones 12(3): 209-18.
Qian, Y., J.S. Venkatraj, R. Barhoumi, R. Pal, A. Datta, J.R. Wild, E. Tiffany-Castiglioni. 2007.
Comparative non-cholinergic neurotoxic effects of paraoxon and diisopropyl
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Evelyn Tiffany-Castiglioni
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fluorophosphate (DFP) on human neuroblastoma and astrocytoma cell lines. Toxicol
Appl Pharmacol 219(2-3): 162-71.
Qian, Y., Y. Zheng, D. Weber, E. Tiffany-Castiglioni. 2007. A 78-kDa glucose-regulated protein
is involved in the decrease of interleukin-6 secretion by lead treatment from astrocytes.
Am J Physiol Cell Physiol 293(3): C897-905.
White, L. D., D.A. Cory-Slechta, M.E. Gilbert, E. Tiffany-Castiglioni, N.H. Zawia, M. Virgolini,
A. Rossi-George, S.M. Lasley, Y. Qian, M.R. Basha. 2007. New and evolving concepts
in the neurotoxicology of lead. Toxicol Appl Pharmacol 225(1): 1-27.
Yang, W., E. Tiffany-Castiglioni. 2007. The bipyridyl herbicide paraquat induces proteasome
dysfunction in human neuroblastoma SH-SY5Y cells. J Toxicol Environ Health A
70(21): 1849-57.
Yang, W., E. Tiffany-Castiglioni. 2008. Paraquat-induced apoptosis in human neuroblastoma
SH-SY5Y cells: involvement of p53 and mitochondria. J Toxicol Environ Health A
71(4): 289-99.
Barhoumi, R., J.M. Catania, A.R. Parrish, I. Awooda, E. Tiffany-Castiglioni, S. Safe, R.C.
Burghardt. 2009. Multiphoton spectral analysis of benzo[a]pyrene uptake and
metabolism in breast epithelial cell lines. J Toxicol Sci 34:13-25.
Yang, W., E. Tiffany-Castiglioni, H.C. Koh, I.-H. Son. 2009. Paraquat activates the
IRE1/ASK1/JNK cascade associated with apoptosis in human neuroblastoma SH-SY5Y
cells. Toxicology Letters 191:203-210.
Qian, Y., Y. Zheng, E. Tiffany-Castiglioni. 2009. Valproate reversibly reduces neurite outgrowth
by human SY5Y neuroblastoma cells, Brain Research 1302:21-33.
Barhoumi, R., Y. Qian, R.C. Burghardt, E. Tiffany-Castiglioni. 2010. Image analysis of Ca2+
signals as a basis for neurotoxicity assays: promises and challenges. Neurotoxicol Teratol
32:16-24.
Yang, W., E. Tiffany-Castiglioni, M.-Y. Li, I.-H. Son. 2010. Paraquat induces cyclooxygenase-2
(COX-2) implicated toxicity in human neuroblastoma SH-SY5Y cells. Toxicology
Letters 199:239-246.
Watanabe, K.H., M.E. Andersen, N. Basu, M.J. Carvan III, K.M. Crofton, K.A. King, C. Suñol,
E. Tiffany-Castiglioni, I.R. Schultz. 2011. Defining and modeling known adverse
outcome pathways: Domoic acid and neuronal signaling as a case study. Environmental
Toxicology and Chemistry 30:9-21.
Tiffany-Castiglioni, E., S. Hong, Y. Qian. 2011. Copper handling by astrocytes: Insights into
neurodegenerative diseases. International Journal of Developmental Neuroscience 29:
811-818.
Qian, Y., Y. Zheng, R. Taylor, E. Tiffany-Castiglioni. 2012. Involvement of molecular
chaperone Hspa5 in copper homeostasis in astrocytes. Brain Research 1447:9-19.
Tiffany-Castiglioni. E. , Y. Qian. 2012. ER chaperone-metal interactions: links to protein
folding disorders. Neurotoxicology 33:545-557.
Tiffany-Castiglioni, E., R. Barhoumi, and Y. Mouneimne. 2012. Kohl and surma eye cosmetics
as significant sources of lead (Pb) exposure. Journal of Local & Global Health Science
vol. 1. DOI: 10.5339/jlghs.2012.1
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Evelyn Tiffany-Castiglioni
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Qian, Y., B. Meng, X. Zhang, Y. Zheng, Ying, R. Taylor, E. Tiffany-Castiglioni. 2013. HSPA5
forms specific complexes with copper. Neurochemical Research 38:321-329.
http://dx.doi.org/10.1007/s11064-012-0925-8
Moreno, J. A., E. Tiffany-Castiglioni. The chaperone grp78 in protein folding disorders of the
nervous system. Neurochemical Research. In press. DOI: 10.1007/s11064-014-1405-0.
Poems in Refereed Journals:
Tiffany-Castiglioni, E. 1990. Sonnet to a Growth Cone. Perspectives in Biology and Medicine
34:525.
Tiffany-Castiglioni, E. 1990. Axoplasmic Journey. Perspectives in Biology and Medicine
34:619.
Tiffany-Castiglioni, E. 2002. Ode to Iodide. Medical Humanities. 28:31.
Refereed Proceedings/Monographs:
Tiffany-Castiglioni, E., L.V. Sheeler-Gough. 1988. Inhibition of glutamine synthetase activity
in cultured astroglia by ferrous chloride. 1988. In: Biochemical Pathology of Astrocytes,
M.D. Norenberg, ed. Alan R. Liss, New York. pp. 535-536.
Rowles, T.K., C. Womac, G.R. Bratton, E. Tiffany-Castiglioni. 1988. Interaction of lead and
zinc in cultured astroglia. In: Biochemical Pathology of Astrocytes, M.D. Norenberg, ed.
Alan R. Liss, New York. pp. 235-236.
Hannemann, W., M. Legare, R. Barhoumi, X. Wong, R. Burghardt, E. Tiffany-Castiglioni, S.
Safe. 1993. 2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced elevation of intracellular
calcium ions in cultured rat hippocampal neurons and astroglia. Organohalogen
Compounds 13:309-312.
Chapters:
Perez-Polo, J.R., C.P. Reynolds, E. Tiffany-Castiglioni, M. Ziegler, I. Schulze, K. Werrbach-
Perez. 1982. NGF effects on human neuroblastoma lines: A model system. In: Proteins
in the Nervous System: Structure and Function, J. Coulter, B. Haber and J.R. Perez-Polo,
eds. Alan R. Liss, New York, pp. 285-299.
de Vellis, J., W.W. Peng, S.K.R. Pixley, E. Tiffany-Castiglioni. 1983. Oligodendroglial,
astroglial, and glial tumor-associated antigens defined by monoclonal antibodies. In:
Protides of the Biological Fluids, Peeters, ed. Pergamon Press, New York, pp. 99-102.
Perez-Polo, J.R., E. Tiffany-Castiglioni, K. Werrbach-Perez. 1983. Model clonal system for
study of neuronal cell injury. In: Nervous System Regeneration. Birth Defects: Original
Article Series, Volume 19, Number 4, B. Haber, J.R. Perez-Polo, G.A. Hashim, and
A.M.G. Stella, eds. Alan R. Liss, New York, pp. 201-220.
Tiffany-Castiglioni, E., A.J. Castiglioni. 1986. Astrocytes in epilepsy. In: Astrocytes, Vol. 3,
Cell Biology and Pathology of Astrocytes, S. Federoff and A. Vernadakis, eds. Academic
Press, Orlando. pp. 401-424.
Tiffany-Castiglioni, E., M.E. Legare, L.A. Schneider, E.D. Harris, R. Barhoumi, J. Zmudzki, Y.
Qian, R. C..Burghardt. 1996. Heavy metal effects on glia. In: Methods in
Curriculum Vitae
Evelyn Tiffany-Castiglioni
Page 17
Neurosciences, Vol. 30, J. Regino Perez-Polo, ed. Academic Press, New York. pp. 135-
165.
Tiffany-Castiglioni, E., Marie E. Legare, Lora A. Schneider, William H. Hanneman, Elisabeth
Zenger, Sandra Hong. 1996. Astroglia and lead neurotoxicity. In: The Role of Glia in
Neurotoxicity, M. Aschner and H.K. Kimelberg, eds. CRC Press, Boca Raton. pp. 175-
200.
Harris, E.D., Y. Qian, E. Tiffany-Castiglioni. 1997. Copper in tissue culture. In: Trace
Elements in Laboratory Rodents: Nutritional Research Methods, R.R. Watson, ed. CRC
Publishers, Boca Raton. pp.163-187.
Harris E.D., M.C.M. Reddy, Y. Qian, E. Tiffany-Castiglioni, S. Majumdar, and J. Nelson. 1999.
Multiple forms of the Menkes Cu-ATPase. In: Copper Transport and Its Disorders:
Molecular and Cellular Aspects. A. Leone and J.F. .Mercer (eds.) Plenum Publishing
Corp. pp. 39-51
Tiffany-Castiglioni, E., 2004. In vitro neurotoxicology: introduction to concepts. In: In Vitro
Toxicology: Principles and Challenges, E.Tiffany-Castiglioni, ed.. Humana Press,
Totowa, New Jersey, pp. 1-28.
Tiffany-Castiglioni, E., Y. Qian. 2004. Cell-type specific responses of the nervous system to
lead. In: In Vitro Toxicology: Principles and Challenges, E.Tiffany-Castiglioni, ed.
Humana Press, Totowa, New Jersey, pp. 151-186.
Tiffany-Castiglioni, E., L.G. Costa, M. Ehrich, W.R. Mundy, G.J. Audesirk, M. Aschner, P.R.S.
Kodavanti, S.M. Lasley. 2004. Appendix: annotated reading list. In: In Vitro
Toxicology: Principles and Challenges, E.Tiffany-Castiglioni, ed. Humana Press,
Totowa, New Jersey, pp. 315-323.
Tiffany-Castiglioni, E., Y. Qian. 2004. Astroglia and lead neurotoxicity. In: The Role of Glia
in Neurotoxicity, 2nd
Ed. M. Aschner and L.G. Costa, eds. CRC Press, Boca Raton. pp.
417-438.
Tiffany-Castiglioni, E., J.S. Venkatraj, Y. Qian, J. R. Wild. 2006. In vitro models for testing
organophosphate-induced neurotoxicity and remediation. In: Toxicology of
Organophosphate & Carbamate Pesticides, Ramesh C. Gupta. Elsevier, Amsterdam. pp.
315-337.
Kern R.J., M.E. Wales, E. Tiffany-Castiglioni, J. R. Wild. 2009. Protection of
acetylcholinesterase from organophosphates: kinetic insight into bioscavengers. In:
Handbook of Toxicology of Chemical Warfare Agents. Ramesh Gupta, ed. Elsevier, San
Diego, CA. pp. 1014-1054.
Tiffany-Castiglioni, E., Y. Qian, R. Barhoumi, Y. Zheng. 2011. Chapter 3: Determination of
metal interactions with the chaperone Hspa5 in human astrocytoma cells and rat astrocyte
primary cultures. In: In Vitro Neurotoxicology: Methods and Protocols, Methods in
Molecular Biology, vol. 758. Lucio G. Costa et al. eds. pp. 29-48.
Books: Tiffany-Castiglioni, E., Editor. 2004. In Vitro Toxicology: Principles and Challenges. Humana
Press, Totowa, New Jersey. 2nd
edition under contract with Springer for 2014.
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Evelyn Tiffany-Castiglioni
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Non-Refereed Publications: Tiffany-Castiglioni, E., J. Zmudzki, G.R. Bratton. 1986. Lead encephalopathy in calves: in vitro
model for cellular targets of lead neurotoxicity. Texas Agricultural Experiment Station
Progress Reports. Beef Cattle Research in Texas. CPR 4494:71-72.
Tiffany-Castiglioni, E., J. Zmudzki, J.-N. Wu. 1986. Cellular mechanisms of lead
encephalopathy: alteration of intracellular trace metal concentrations in cultured astroglia.
Texas Agricultural Experiment Station Progress Reports. Beef Cattle Research in Texas.
CPR 4493:71.
Tiffany-Castiglioni, E. 1986. Review: Genetics and management of kemp in mohair. Texas
Agricultural Experiment Station Progress Reports. Sheep and Goat, Wool and Mohair.
CPR 4403:60-67.
Tiffany-Castiglioni, E. 1986. Radiation protective agents. In: Biotechnology and the Air Force,
Vol. II, Elements with Genetic Engineering (Occasional Paper No. 11). Center for
Strategic Technology, TAES, Texas A&M University. pp. 251-262.
Tiffany-Castiglioni, E. 1986. Biodetectors for hazards. In: Biotechnology and the Air Force,
Vol. III, Conventional Biological Concepts, (Occasional Paper No. 11). Center for
Strategic Technology, TAES, Texas A&M University. pp. 83-92.
Tiffany-Castiglioni, E. 2000. In vitro neurotoxicology: Potential applications to space radiation
health risks. Neuroscience and Radiation Biology Working Group Workshop, Houston,
TX. pp. 82-93.
Tiffany-Castiglioni, E. 2000. Development of a human cell culture model that distinguishes
classes of organophosphate neurotoxicants. In: Alternatives Today, JE McArdle, ed.
Summer/Fall 2000, pp. 1, 6-7.
Tiffany-Castiglioni, E. 2001. Book Review: Introduction to neurobehavioral toxicology: Food
and environment. Pharmacology and Toxicology: Basic and Clinical Aspects. In: The
Quarterly Review of Biology. pp. 525.
Tiffany-Castiglioni, E. Summer 2003. Forum on Science and Technology: 98.5% Pure Chimp.
Phi Kappa Phi Forum, 83(3):6-7.
Tiffany-Castiglioni, E. Winter 2004. Forum on Science and Technology: Chicken Liver and the
Soul. Phi Kappa Phi Forum, 84(1):6-7.
Tiffany-Castiglioni, E. Summer 2004. Forum on Science and Technology: The Domestication
of the Dog, Part I. Phi Kappa Phi Forum, 84(3):6-9.
Tiffany-Castiglioni, E. Winter/Spring 2005. Forum on Science and Technology: The
Domestication of the Dog, Part II. Phi Kappa Phi Forum, 85(1):6-7.
Tiffany-Castiglioni, E. Fall 2005. Forum on Science and Technology: On Being a Scientist.
Phi Kappa Phi Forum, 85(3):6-7.
Tiffany-Castiglioni, E. Summer 2006. Forum on Science and Technology: The World in a
Culture Dish. Phi Kappa Phi Forum, 86(3):6-7.
Tiffany-Castiglioni, E. December 6, 2007, 2011. Invited commentary for Alttox.org The Way
Forward article, “Neurotoxicity: The Way Forward” AltTox.org is a website dedicated
to advancing nonanimal methods of toxicity testing. The website is designed to
Curriculum Vitae
Evelyn Tiffany-Castiglioni
Page 19
encourage the exchange of technical and policy information on in vitro and in silico
methods for all types of toxicity tests.
SERVICE ACTIVITIES:
Professional Organizations and Service:
American Association for the Advancement of Science, 1980-present
American Society for Neurochemistry, 1982 (Member, Education and Teachers Workshop Sub-
committee, 1997)
Texas Society for Electron Microscopy, 1982-1985
Society for Neuroscience, Texas A&M Chapter, 1984-present (Council member, 1985-1986;
President-elect 1986-1987; President 1987-1988; Council Member, 1991-1993)
Tissue Culture Association, 1984-1990
American Association of Veterinary Anatomists, 1987 - present (Member, Awareness
Committee, 1986-1988; Chair, Auditing Committee, 1988; Program Committee, 2000-
2001)
Society for Neuroscience, 1989-present (Representative to Awareness and Communications
Committee, November, 1991)
Gulf Coast Society of Toxicologists, 1994 - present (Secretary, 1994-1995; Vice President Elect,
1995-1996; Vice President, 1996-1997; President, 1997-1998)
Society of Toxicologists, 1997 - present (Neurotoxicology Specialty Section By-Laws
Committee, 1999-2000; Councilor, 2001-2003)
Major Committee Assignments:
Departmental:
Chair, Departmental Graduate Program Committee, 1985-1989
Chair, Search Committee for Faculty Position in Veterinary Anatomy (Electron Microscopy),
1986-1987
Member, Departmental Space Usage Committee, 1987-88
Member, Search Committee for Faculty Position in Veterinary Anatomy and Public Health
(Epidemiology), 1991-1992c
Member, Search Committee for Faculty Position in Veterinary Anatomy, 1993
Member, Search Committee for Faculty Position in Veterinary Anatomy and Public Health
(Anatomy), 1996
Member, Search Committee for Positions in the Dept. of Epidemiology & Biostatistics, School
of Rural Public Health, 1999
Member, Search Committee for Head of Dept. of Human Neuroscience and Anatomy, 2004-
2006
College:
Member, CVM Graduate Instruction Committee, 1984-1989 Member, Biomedical Science Task
Group for Five-Year Plan for College of Veterinary Medicine, Texas A&M University, 1986
Curriculum Vitae
Evelyn Tiffany-Castiglioni
Page 20
Member, Research Planning Committee for the College of Veterinary Medicine, Texas A&M
University, 1986
Member, Steering Committee for Molecular and Cell Biology Training Program, 1986-1990
Member, CVM Selection Committee, 1991-1994
Member, Search Committee for Faculty Position in Veterinary Pathobiology, 1992-1993
Member, Medical Science Library Council, 1992-1995, Chair 1993-1994
Member, CVM Strategic Planning Committee, 1992-1996
Chair, Biomedical Science Executive Committee, 1996-present
Member, College of Veterinary Medicine Executive Committee, 1996-present
Chair, Biomedical Science Curriculum Subcommittee, 1997-2001
Member, CVM Neuroscience Faculty Advisory Committee, 1998-2002
Co-Chair, Search Committee for Bridges Chair in Veterinary Medical Education, 2000-2002
Member, Search Committee for Reed Chair in Cardiovascular Medicine, 2000-2002
Member, Veterinary Medical Teaching Hospital Executive Committee, 2001-2004
TAMU, TAMUS and Other University:
Member, Sheep and Goat Commodity Panel for Texas Agricultural Experiment Station Five-
Year Plan, 1986
Member, Evans Library Council, 1992-1995
Member, Recruiting Committee, Faculty of Neuroscience, 1993-1995
Member, Curriculum Committee, Faculty of Neuroscience, 1993-1995
Member, Executive Committee, Faculty of Toxicology, 1994-present
Elected Member, Council for Principal Investigators, 1996-1998
Elected Member, Faculty Senate, 1997-2003
Member, Academic Affairs Committee, Faculty Senate, 1997-2003Member, International
Programs Committee, Faculty Senate, 2001-2003
Member, Women’s Faculty Network Mentoring Program, 1995-presentMember, Ad Hoc
Implementation Committee to Encourage and Recognize Undergraduate Students Who
Participate in Research and Scholarship, 1997-1998
Member, Search Advisory Committee for Associate Provost for Undergraduate Programs and
Academic Services, 1998
Member, Honors Program Committee, 1997-2000
Member, Faculty Advisory Committee to Vice President for Student Affairs, 1997-2000
Member, Steering Committee for Student Research Week, 1997-2001
Facilitator, Undergraduate Academics Theme Group, Texas A&M University Vision 2020 Task
Force, 1998
Member, Biotechnology MS Steering Committee, 1998-2001
Member, Master of Biotechnology Executive Committee, 2001-2004
Co-Chair, Core Curriculum Oversight Subcommittee, Faculty Senate, 1998-1999
Chair, Core Curriculum Oversight Subcommittee, Faculty Senate, 1999-2000
Member, Life Sciences Task Force, 1998-2000
Chair, Faculty of Genetics Review Steering Committee, 1998-1999
Curriculum Vitae
Evelyn Tiffany-Castiglioni
Page 21
Member, Faculty of Nutrition Review Steering Committee, 1999-2000
Women’s Faculty Network Planning Committee, “Thriving in the Academy” Workshop, 1999
Member, TAMU/FSIS Project Technical Oversight Committee, 1999-2000
Women in Discovery Program Committee, 1999-2000 (Program held March 22-23, 2000)
Member, Research Integrity Investigation Committee, October 2000-2001
Member, Study Abroad Program Policy Committee, Subcommittee on Long-Range Planning and
Anchor Sites, January 2001-2002
Member, Selection Committee for the 2002 Texas A&M Bush Faculty Excellence Award on
International Research
Member, Selection Committee for the 2003 Texas A&M Bush Faculty Excellence Award on
International Teaching
Member, 2003 Distinguished Alumni Award Selection Committee for the Association of Former
Students
Co-Chair, HUB Steering Committee, 2002-2003
Member, Quality Enhancement Planning Council, 2003
Chair, Salary Grievance Committee, 2003
Member, search advisory committee for Head, Department of Neuroscience and Experimental
Therapeutics, College of Medicine, Texas A&M Health Science Center, 2004-2006
President, Graduate School of Biomedical Sciences Associates, University of Texas Medical
Branch, 2006-2008
Member, University of Texas Medical Branch Development Board Executive Council, 2006-
2008
Member, Search Committee for Dean of Undergraduate Programs and Associate Provost for
Academic Services, Fall 2007
Member, Search Committee for Dean of College of Veterinary Medicine and Biomedical
Sciences, 2008
Member, Task Force for Enlightened and Shared Governance, 2009-2010
President, University Summer Performance Series Board 2009-2010
Member, Faculty and Student Advisory Board for the Center for Teaching Excellence, 2011-
2014
Convener, Department Head Steering Committee, April 2014-present
Member, Institutional Assessment and Accountability Advisory Committee (IA3C), 2012-
present; Subcommittee on graduate-level assessment, 2014-present.
External Member, Academic Review Panel, Department of Internal Medicine, University of
Texas Medical Branch (UTMB), September 23-25, 2014.
Member, Texas A&M University President’s Council on Climate and Diversity, September
2014- May 2015.
Professional Program Committees:
American Society for Neurochemistry; Program Committee 1997-1998
Program Committee, American Association for Veterinary Anatomists Meeting with
AAA/FASEB, Orlando, FL, March 30-31, 2001.
Curriculum Vitae
Evelyn Tiffany-Castiglioni
Page 22
Executive Committee, Neurotoxicology Specialty Section, Society of Toxicology, 2001-2003
Program Committee, 21st International Neurotoxicology Conference, Hawaii, 2004
Program Committee, 22st International Neurotoxicology Conference, Research triangle Park,
2005
Program Committee, 23st International Neurotoxicology Conference, Little Rock, Arkansas,
2006
Program Committee, 24th
International Neurotoxicology Conference, San Antonio, Texas,
Arkansas, 2007
Program Committee, 25th
International Neurotoxicology Conference, New York, New York,
2008
Scientific Steering Committee, Third International Conference on Alternatives for
Developmental Neurotoxicity Testing (DNT3), Varese, Italy, 2011
OTHER SCHOLARLY ACTIVITY:
Invited Lectures at National and International Meetings “Primary Astrocyte Systems to Characterize the Neurotoxicity of Chemical Mixtures and Heavy
Metals,” Session-in-Depth. 39th
Annual Meeting of the Tissue Culture Association, Las
Vegas, NV. June 14,1988.
“Biomarkers of Neuroglia in Disease and Aging,” Roundtable. 40th
Annual Meeting of the
Tissue Culture Association, Orlando, FL. June 11-14, 1989.
“Biomarkers of Neurotoxicity in Cultured Astrocyte and Glioma Cell Lines,” 41st Annual
Meeting of the Tissue Culture Association, Session-in-Depth: Biomarkers of
Cytotoxicity, Houston, TX. June 11, 1990.
“Sensitive Detection of Lead-induced Molecular Injury in Cultured Astroglia by Laser
Cytometry,” EPA Neurotoxicology Program Project Workshop, The John Hopkins
University, Center for Alternatives to Animal Testing, Baltimore, MD, May 3, 1991.
“Cell Culture Models for Lead Toxicity in Neuronal and Glial Cells,” 9th
International
Neurotoxicology Conference, New Dimensions of Lead Neurotoxicity: Redefining
Mechanisms and Effects, Little Rock, AR. October 28-31, 1991.
“Molecular Interactions of Lead in Cultured Astroglia,” World Congress on Cell and Tissue
Culture, Session-in-Depth: Metabolic and Molecular Injury by Metals, Washington, D.C.
June 22, 1992.
“Pb(II) and Fe(II) in Glia,” 25th
Annual Meeting of the American Society for Neurochemistry,
Workshop: Trace Metal Ions in the CNS: Dynamics and Regulation, Richmond, VA.
March 21-26, 1993.
“Congener-Specific Effects of Dioxins in Neuronal and Glial Cultures,” 25th
Annual Meeting of
the American Society for Neurochemistry, Colloquium: Neural Targets of
Environmental Toxins, Albuquerque, NM. March 5-9, 1994.
“Use of Cell Cultures to Study Effects of Neurotoxicants,” Special Symposium for Science
Educators, Public Policy Forum, 25th
Annual Meeting of the American Society for
Neurochemistry, Albuquerque, NM. March 5-9, 1994.
Curriculum Vitae
Evelyn Tiffany-Castiglioni
Page 23
“Lead Toxicity in Neurons,” Special Symposium for Science Educators, Public Policy Forum,
Twenty-Sixth Annual Meeting of the American Society for Neurochemistry, Santa
Monica, CA. March 5-9, 1995.
“Astroglial Responses to Neurotoxicants,” Invited speaker for Colloquium entitled “Role of
Astrocytes in Neurologic Disease,” Michael Norenberg, chair. 29th
Annual Meeting of
the American Society for Neurochemistry, Denver, CO. March 7-11, 1998.
“Astroglia as Metal Depots (Pb,Cu,Mn, and Hg): Molecular Mechanisms for Metal
Accumulation, Storage and Release, and Neurotoxicity,” Session VI: Roles of Glia in
Developmental Neurotoxicology, Evelyn Tiffany-Castiglioni and Consuelo Guerri, Co-
Chairs. 18th
International Conference on Neurotoxicology, Colorado Springs, CO.
September 23-26, 2000.
“In Vitro Neurotoxicology: Potential Applications to Space Radiation Health Risks,” Invited
presenter and participant for Neuroscience & Radiation Biology Working Group, NASA,
Center for Advanced Space Studies, Houston, TX. Dec 5-6, 2000.
“Cell-Type Specific Neural Responses: Differential Sensitivities of Neurons and Neuroglia to
Low-Level Lead Exposure,” Continuing Education Course for Society of Toxicology,
William Slikker, chair, 40th
Annual Meeting, San Francisco, CA. March 25, 2001.
“Astroglia as Metal Repositories: Links to Neurodegenerative Diseases,” Invited speaker and
chair for workshop on “In Vitro Neurotoxicology: Tools for Cellular Neurobiology,”
33rd
Annual Meeting of the American Society for Neurochemistry, West Palm Beach, FL.
June 22-26, 2002.
“Genetic Polymorphisms and Mechanisms of Neurotoxicity: Overview,” Invited speaker and
chair for session on “Genetic Polymorphisms and Mechanisms of Neurotoxicity,” 21st
International Neurotoxicology Conference, Honolulu, HI. February 10-14, 2004.
“Cell-Specific Responses to Lead and Other Neurotoxicants,” Invited speaker and chair,
Continuing Education Course on “Basic Neurotoxicology” for Society of Toxicology
42nd
Annual Meeting, Baltimore, MD. March 20-25, 2004.
“Concepts of In Vitro Neurotoxicology: Applications to Drug Discovery,” Invited speaker for 5th
International Conference on Early Toxicity Screening: Strategies and Approaches for
Toxicity Screening in Drug Discovery and Development, Jean Harry, session chair, San
Diego, CA. February 21-23, 2005.
“In Vitro Models for Testing Neurotoxicity of Organophosphorus Compounds and Protective
Effects of OP Hydrolase,” Invited speaker for Symposium on “Neurotoxicity of
Organophosphates & Carbamates,” Ramesh Gupta, chair, Society of Toxicology 43nd
Annual Meeting, New Orleans, LA. March 20-25, 2005.
“In Vitro Models for Testing Neurotoxicity of Organophosphorus Compounds,” invited speaker
and chair for Symposium on “In Vitro Models and Biosensors for Detecting
Neurotoxicity,” 10th
Meeting of the International Neurotoxicology Association, Porvoo,
Finland. June 26-July 1, 2005.
“Metal Accumulation by Astrocytes: Relationship to Disease,” Invited speaker and chair for
Colloquium on “Astrocytes in Neurodegenerative Disease Processes,” International
Curriculum Vitae
Evelyn Tiffany-Castiglioni
Page 24
Society for Neurochemistry-European Society for Neurochemistry Congress, Innsbruck,
Austria. August 21-26, 2005.
“In Vitro Models for Assessing Neurotoxicity of Mixtures,” Invited speaker and chair for
platform session on Neurotoxicity of Mixtures, Solvents, and Metals In Vivo and In
Vitro,” 22nd International Neurotoxicology Conference, Environmental and
Neurodevelopmental Disorders, Research Triangle Park, North Carolina. September 11-
14, 2005.
“In Vitro Models of Neural Responses to Lead (Pb),” Invited speaker for Symposium on New
Concepts in the Neurotoxicology of Lead, Lori White, chair, Society of Toxicology 44th
Annual Meeting, San Diego, CA. March 5-9, 2006.
“In Vitro Systems and Developmental Neurotoxicity,” Plenary speaker for TestSmart
Developmental Neurotoxicity Testing meeting, sponsored by Center for Alternatives to
Animal Testing (CAAT), Johns Hopkins University, NIH, and EPA, Washington, DC.
March 13-15, 2006.
“In Vitro Systems and Developmental Neurotoxicity,” Invited speaker and chair for plenary
session on “Neurotoxicity in Development and Aging: Translational Research,” 23rd
International Neurotoxicology Conference, Little Rock, Arkansas. September 17-21,
2006
“Lead Effects on Molecular Chaperones: a Link to Neurodegenerative Diseases?” Invited
speaker and chair for platform session on “Fetal Basis for Adult Disease,” 24th
International Neurotoxicology Conference, San Antonio, Texas. November 11-14, 2007
“Chaperone Deficiency in Pb-exposed Glia: Links to Neurodegenerative Diseases.” Invited
speaker for session on “Glia-Neuron Interactions in Neurotoxicology.” The XII
International Congress of Toxicology, Barcelona-Spain, July 19-23, 2010
“ER Chaperone-Metal Interactions: Links to Protein Folding Disorders,” Invited speaker and
chair for Workshop Session on “Environmental Factors in Neurodegenerative Diseases,”
Society of Toxicology 52nd
Annual Meeting, San Antonio, TX. March 11-14, 2013.
Invited Lectures at Universities and Regional Meetings “Astroglia in Epilepsy: Cell Culture Model,” Human Biological Chemistry and Genetics
Seminar Series, University of Texas Medical Branch at Galveston, May 23, 1986.
“Seizure Related Enzymes in Astroglia in Culture,” Department of Medical Pharmacology
seminar program, Texas A&M University, October 6, 1986.
“Astroglia in Epilepsy: Cell Culture Model,” Department of Medical Physiology Seminar
Program, Texas A&M University, December 12, 1986.
“Effects of Lead on Neuroglia,” Environmental Toxicology and Pharmacology seminar program,
Texas A&M University, February 16, 1987.
“Lead Toxicity in Neuroglia,” Department of Medical Pharmacology and Toxicology seminar
program, Texas A&M University, April 4, 1988.
“Development of Primary Astrocyte Systems to Characterize Neurotoxic Chemical Mixtures and
Heavy Metals,” Symposium, Southwest Environmental Mutagen Society and Gulf Coast
Society of Toxicology Joint Annual Meeting, Galveston, TX, November 12, 1988.
Curriculum Vitae
Evelyn Tiffany-Castiglioni
Page 25
“Astrocytes in Culture to Characterize Neurotoxins,” Symposium, Annual Meeting of the Tissue
Culture Association, Texas Chapter, Houston, TX, April 14, 1989.
“Lead Toxicity in Neuroglia,” MBRS, MARC Seminar Programs, The University of Texas at
San Antonio, January 26, 1990.
“Responses of Astroglia to Lead and Iron Exposure,” Cellular and Structural Biology Seminar
Series, The University of Texas at San Antonio, March 14, 1990.
“Cellular Mechanisms of Low Level Lead Neurotoxicity,” School of Science, Engineering and
Technology and MBRS/MARC Programs Seminar Series, Saint Mary's University, San
Antonio, Texas, February 9, 1990.
“Interaction of Heavy Metals with Glia,” Pharmacology and Toxicology Lecture series,
Department of Pharmacology and Toxicology, TAMU, December 18, 1990.
“Approaches to Understanding Lead-Calcium Interactions in Cultured Brain Cells,” The
Graduate Faculty of Nutrition, TAMU, February 13, 1991.
“Cellular Mechanisms of Lead Neurotoxicity,” Faculty of Toxicology Seminar Series, TAMU,
April 1, 1991.
“Subcellular Targets of Lead Injury in Cultured Neural Cells,” Toxicology Seminar Series at
University of Texas Medical Branch at Galveston, March 23, 1994.
Dean’s Panel, MAES/MANRRS 3rd
Annual Science Symposium, TAMU, March 22, 1997
Careers in Academia, Special Seminar for Students, TAMU, July 11, 1997
“Neuroactivity of Dioxin in Cell Cultures and Brain Slices,” Invited seminar speaker,
Toxicology group, UTHSC, Houston, TX, October 2, 1997.
“Toxicology at Texas A&M University,” invited seminar speaker, Biology group, Austin
College, Sherman, TX, October 16, 2000.
“What Mentors Should Expect,” Mentoring Relationships Workshop, Graduate Studies in
Biomedical Sciences, University of Texas Medical Branch, Galveston, TX, October 19,
2001.
“Infertility, Heart Attacks, & Parkinson’s Disease : Does Pollution Play a Role?” National
Institute of Environmental Health Regional Town Meeting, Houston, TX, October 20,
2001.
“Metal Accumulation by Astrocytes: Relationship to Disease,” College of Veterinary Medicine,
University of Cambridge, July 5, 2005.
“Metal Accumulation by Astrocytes: Relationship to Disease” Wolfson Centre for Age-Related
Diseases, King’s College, London, July 4, 2005.
“Metal Accumulation by Astrocytes: Relationship to Disease” Columbia University,
Neurotoxicology/Neurodegenerative Disease Research Core of the NIEHS Center for
Environmental Health, New York, December 8, 2005.
“Lead Effects on Molecular Chaperones: A Link to Neurodegenerative Disease?” NSF Advance
Seminar, Kansas, October 31, 2007.
“ER Chaperone-Metal Interactions: Links to Protein Folding Disorders” School of Veterinary
and Biomedical Sciences Fall Seminar, University of Nebraska-Lincoln, October 14,
2013.
Curriculum Vitae
Evelyn Tiffany-Castiglioni
Page 26
Other Activities Departmental Graduate Advisor, 1984-1989
Faculty sponsor for University Undergraduate Fellows program: Ritt Enderson (1984-85), Dana
Garcia (1985-1986), Rebekah Stevenson (1995-1996), Laura Bird (1997-1998)
Faculty mentor for Veterinary student summer research program: Sharyn Jones (1987); Glenda
Wall (1987); Nancy Mahoney (1991)
Faculty mentor for Young Women's Summer Intern Program, 1991, 1992, 1993
Faculty mentor for minority student summer research internships: Angelica Duran (1992); Grace
Hsieh (1993); Theresa Cardena (1994); Frances Valencia (2004)
Faculty mentor for Young Scholars' Intern Program: Carmen Bethel (1994).
Volunteer Scientist, Science-by-Mail National Pen-pal Program, 1992-1997
Faculty mentor for Howard Hughes Medical Internship Program: Jose Gonzalez (1994), Erica
Bell (1994); Yvonne Contreras (1996)
Sponsor for Minority Supplement, NIH: Hans Kocher (1995)
Reviewer, Children's Books for Appraisal Magazine (1991-1999)
Consultant and trainer in cell culture techniques (for undergraduate and graduate students from
other laboratories and departments) - approximately 45 students in the past 15 years
Moderator, Panel Discussion: Managing a Research Group (Panel members: Karen Butler,
Marchette Darensbourg, Joanne Lupton, and Wendy Wood). October 22, 1997, Texas
A&M University
Mentor for Roger Solano, Anakletic Laboratory Program in the Sciences (1998)
Mentor for Gwyneth Crowley, Instructor, Women’s Faculty Network, 1997-2002
Mentor for Susan Lynham, Assistant Professor, Women’s Faculty Network, 2002-2004
Presented “Outsmarting Entropy” at the Women in Science and Engineering Career
Development Conference (1998)
Judge at Annual Student Research Week Competition, March 1998, March 1999, March 2001,
and March 2002
Panel Member, “How can we best focus on multiple missions and equate them with
scholarship?” Scholarship Identified and Rewarded, Texas A&M University, March 1999
Member, Executive Committee of Graduate School of Biomedical Sciences’ Alumni
Association, The University of Texas Medical Branch at Galveston, June 1999-present
Participant in the 1999 Student Summer Research Seminar Program
Presented “The Use of Cell Cultures as a Research Tool” to participants in the Anakletic
Laboratory Program in the Sciences, July, 1999
Moderator, Senior Faculty Panel Discussion: Thriving in the Academy: A Professional
Development Workshop for Female Faculty (Panel Members: Janis Stout, Vivian Paul,
Karan Watson, Karen Kubena, Mary Jo Richardson), Del Lago Conference Center,
Conroe, TX, Friday-Saturday, October 22-23, 1999
Moderator, Panel Discussion: The Future of Science (Panel Members: Bonnie J. Dunbar, Carol
A. Gross, Heidi B. Hammel, Carol A. Nacy). Women in Discovery: Celebrating the Life
of Marie Curie, Bush Conference Center, College Station, TX, March 23, 2000
Moderator, Panel Discussions for Women in Science and Engineering (WISE) at Texas A&M
Curriculum Vitae
Evelyn Tiffany-Castiglioni
Page 27
University, Memorial Student Center: “Creating a Positive Career Experience”
Conference, February 20, 1999; “Finding the Balance” Conference, February 18 & 19,
2000; “Achieving Your Vision” Conference, February 16 & 17, 2001; “Women in
Transition” Conference, February 16, 2002.
Performer, Faculty Artist Showcase, Rudder Auditorium, Evelyn Tiffany-Castiglioni, soprano,
“Tutti fior” duet from Madame Butterfly (Puccini) with Lori Fredrics, mezzo-soprano,
and “Deh vieni non tardar” aria from Marriage of Figaro (Mozart), March 22, 2002.
Speaker, Texas A&M University Neurological Society, April, 2002
Speaker, Biomedical Science Association Pre-Vet Meeting, 2003
Performer, Faculty Showcase, Rudder Auditorium, Evelyn Tiffany-Castiglioni, harpist, medley
of Scottish tunes duet with Eden Schmeichel, flutist, March 25, 2006.
National Institute of Health, Panel Discussion, Rudder at Texas A&M University, February 6,
2007
Speaker, Raytheon Asian Pacific Association (RAPA), “Mentoring Relationships Workshop,”
Arlington, TX, September 8, 2007
Member, Texas A&M University ADVANCE LEAD (Leaders Engaging ADVANCE
Departments) Program Committee, 2012-present
Panel member, CVM mock NIH review presentation for graduate students and post-doctoral
fellows, 2012
Member, ADVANCE Award and Search Committee Training Committee, 2012
Invited planner and presenter, ADVANCE Faculty Evaluation Workshop for Department Heads,
Texas A&M University, February 27, 2013
Invited Panel Member for NSF Graduate Research Fellowship Informational Meeting hosted by
the College of Veterinary Medicine & Biomedical Sciences Office of the Associate Dean
for Research and Graduate Studies, September 19, 2013
Speaker, Bridge to Doctorate program, a subsection of the Louis Stokes Alliance for Minority
Participation (LSAMP) at Texas A&M University, “Mentoring in Graduate School,”
March 7, 2013; September 26, 2013
Invited Facilitator for Dean of Faculties, Faculty Professional Development Series – Faculty
Mentoring, September 26, 2013
Invited Panelist for 2014 Research Institute for Women and Underrepresented Groups, Texas
A&M Health Science Center, August 6-8, 2014
Invited Panelist for New Academic Leader Orientation, entitled “Developing Faculty into
Productive Scholars, Teachers, and Citizens, Texas A&M University, August 22, 2014.
Evidence of National and International Recognition 1) Tissue Culture Association
Co-Chair for Roundtable, “Biomarkers for in Vitro Toxicity”
Orlando, FL, June 11-14, 1989
2) World Congress on Cell and Tissue Culture
Co-Chair for Session-in-Depth: Metabolic and Molecular Injury by Metals
Washington, D.C., June 21-25, 1992
Curriculum Vitae
Evelyn Tiffany-Castiglioni
Page 28
3) 25th
Annual Meeting of the American Society for Neurochemistry
Chair for Colloquium: Neural Targets of Environmental Toxins
Albuquerque, NM, March 5-9, 1994
4) Gulf Coast Society of Toxicology Annual Meeting, Convener (as President)
College Station, TX, November 13-15, 1997
5) 37th
Society of Toxicology Annual Meeting 1998
Convener for poster discussion session entitled “Bridging the Gap Between In Vitro and
In Vivo Models for Neurotoxicology”
Seattle, WA, March 1998
6) 38th
Society of Toxicology Annual Meeting
Invited co-chair for poster session entitled “Neurotoxicology of Non-metals”
New Orleans, LA, March 14-18, 1999
7) Invited to edit a volume of Methods in Pharmacology and Toxicology (Humana Press,
Mannfred Hollinger, Series Editor) on In vitro Systems for the Study of Neurotoxicology.
Published 2004
8) 18th
International Neurotoxicology Conference: Children’s Health and the Environment
Invited Convener for symposium on “Role of Glia in Developmental Neurotoxicity”
Colorado Springs, CO, September 23-26, 2000
9) 39th
Society of Toxicology Annual Meeting.
Invited co-chair for poster session entitled “Neurotoxicology of Metals”
Philadelphia, PA, March 19-23, 2000
10) Interviewed on the subject of metals on radio program, “Health Show,” (broadcast on 200
U.S. stations and Voice of America and the Armed Forces Radio Network), February
2001
11) 40th
Society of Toxicology Annual Meeting
Invited co-chair for poster session entitled “Organophosphates”
Nashville, TN, March 17-21, 2002
12) 33rd
Annual Meeting of the American Society for Neurochemistry
Convener and invited speaker for Workshop: “In Vitro Neurotoxicology: Tools for
Cellular Neurobiology”, Palm Beach, FL, June 22-26, 2002
13) Society of Toxicology 41st Annual Meeting
Invited chair for poster session entitled “Metal Neurotoxicity”
Salt Lake City, Utah, March 9-13, 2003
14) Columnist for “Science and Technology,” Phi Kappa Phi Forum.
2003-2006
15) 21st International Neurotoxicology Conference
Program committee and session chair, “Genetic Polymorphisms and Mechanisms of
Neurotoxicity,” Honolulu, Hawaii, February 10-14, 2004
17) Society of Toxicology 42nd
Annual Meeting
Invited chair, Continuing Education Course in “Basic Neurotoxicology”
Baltimore, MD, March 20-25, 2004
18) External examiner for a Master Thesis Exam (Environmental Health) at United Arab
Curriculum Vitae
Evelyn Tiffany-Castiglioni
Page 29
Emirates University, Al Ain, Abu Dhabi, January 9, 2005
19) 5th
International Conference on Early Toxicity Screening: Strategies and Approaches for
Toxicity Screening in Drug Discovery and Development
Invited speaker, San Diego, CA, February 21-23, 2005
20) Society of Toxicology 43nd
Annual Meeting
Invited speaker, symposium on “Neurotoxicity of Organophosphates & Carbamates”
New Orleans, LA, March 20-25, 2005
21) 10th
Meeting of the International Neurotoxicology Association
Invited chair, symposium on “In Vitro Models and Biosensors for Detecting
Neurotoxicity," Porvoo, Finland, June 26-July 1, 2005
22) International Society for Neurochemistry-European Society for Neurochemistry Congress
Invited chair, colloquium on “Astrocytes in Neurodegenerative Disease Processes,”
Innsbruck, Austria, August 21-26, 2005
23) 22nd
International Neurotoxicology Conference
Program committee and session chair, “Genetic Polymorphisms and Mechanisms of
Neurotoxicity,” Research Triangle Park, North Carolina, September 11-14, 2005
24) External examiner for a Master Thesis Exam (Environmental Health) at United Arab
Emirates University, Al Ain, Abu Dhabi, November 18, 2005
25) TestSmart Developmental Neurotoxicity Testing meeting, sponsored by Center for
Alternatives to Animal Testing (CAAT), Johns Hopkins University, Invited plenary
speaker, Washington, DC, March 13-15, 2006
26) 23rd
International Neurotoxicology Conference
Program committee and plenary session chair, “Neurotoxicity in Development and
Aging: Translational Research,” Little Rock, Arkansas, September 17-21, 2006
27) 24th
International Neurotoxicology Conference
Program committee and platform session chair, “Fetal Basis for Adult Disease,” San
Antonio, Texas. November 11-14, 2007
28) 39th
American Society for Neurochemistry
Invited platform session chair, “Neurotoxicity and Neurodegeneration,” San Antonio,
Texas. March 1-5, 2008
External Advisory Committee for NIH Superfund Program application entitled
“Superfund Metal Mixtures, Biomarkers and Neurodevelopment,” Harvard School of
Public Health & Harvard Medical School, David Bellinger, PI, 2008-present.
29) External Advisory Committee for NIH Superfund Program application entitled
“Superfund Metal Mixtures, Biomarkers and Neurodevelopment,” Harvard School of
Public Health & Harvard Medical School, David Bellinger, PI, 2008-present.
30) The XII International Congress of Toxicology
Invited speaker, “Chaperone Deficiency in Pb-exposed Glia: Links to Neurodegenerative
Diseases,” Barcelona, Spain, July 19-23, 2010
31) Third International Conference on Alternatives for Developmental Neurotoxicity Testing
(DNT3) Scientific Steering Committee member and invited session chair, “Overview of
Alternative Model Development,” Ville Ponti Congress Centre, Varese, Northern Italy.
Curriculum Vitae
Evelyn Tiffany-Castiglioni
Page 30
May 10-13, 2011
32) Society of Toxicology 52nd Annual Meeting
Chair and Invited speaker, session on “Environmental Factors in Neurodegenerative
Diseases,” San Antonio, TX, March 11-14, 2013
