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Contributors CONSULTING EDITOR RICHARD W. CARLSON, MD, PhD Chairman Emeritus, Department of Medicine, Maricopa Medical Center; Director, Medical Intensive Care Unit; Professor, University of Arizona College of Medicine; Professor, Department of Medicine, Mayo Graduate School of Medicine, Phoenix, Arizona GUEST EDITOR MITCHELL M. LEVY, MD Division of Pulmonary and Critical Care Medicine, Rhode Island Hospital, The Warren Alpert Medical School of Brown University, Providence, Rhode Island AUTHORS CHARLES A. ADAMS Jr, MD, FACS Assistant Professor of Surgery, Warren Alpert School of Medicine of Brown University; Chief, Division of Trauma and Surgical Critical Care, Rhode Island Hospital; Medical Director, Surgical and Trauma Intensive Care Units, Rhode Island Hospital, Providence, Rhode Island ANTONIO ARTIGAS, MD, PhD Critical Care Center, Hospital de Sabadell, Sabadell; CIBER Enfermedades Respiratorias, Instituto Universitario Parc Tauli, Universidad Auto ´ noma de Barcelona, Barcelona, Spain DAMIEN BARRAUD, MD Medical ICU, University Hospital of Nancy, Nancy, France BRIAN CASSERLY, MD Assistant Professor, Division of Pulmonary and Critical Care Medicine, The Memorial Hospital of Rhode Island, Pawtucket, Rhode Island PHIL DELLINGER, MD Professor of Medicine, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School; Head, Division of Critical Care Medicine, Cooper University Hospital, Camden, New Jersey KATIA DONADELLO, MD Department of Intensive Care, Erasme Hospital, Universite ` Libre de Bruxelles, Brussels, Belgium LANCE D. DWORKIN, MD Professor of Medicine, Division of Kidney Diseases and Hypertension, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, Rhode Island Biomarkers in the Critically Ill Patient

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Biomarkers in the Critically Ill Patient

Contributors

CONSULTING EDITOR

RICHARD W. CARLSON, MD, PhDChairman Emeritus, Department of Medicine, Maricopa Medical Center; Director,Medical Intensive Care Unit; Professor, University of Arizona College of Medicine;Professor, Department of Medicine, Mayo Graduate School of Medicine,Phoenix, Arizona

GUEST EDITOR

MITCHELL M. LEVY, MDDivision of Pulmonary and Critical Care Medicine, Rhode Island Hospital, The WarrenAlpert Medical School of Brown University, Providence, Rhode Island

AUTHORS

CHARLES A. ADAMS Jr, MD, FACSAssistant Professor of Surgery, Warren Alpert School of Medicine of Brown University;Chief, Division of Trauma and Surgical Critical Care, Rhode Island Hospital; MedicalDirector, Surgical and Trauma Intensive Care Units, Rhode Island Hospital,Providence, Rhode Island

ANTONIO ARTIGAS, MD, PhDCritical Care Center, Hospital de Sabadell, Sabadell; CIBER Enfermedades Respiratorias,Instituto Universitario Parc Tauli, Universidad Autonoma de Barcelona, Barcelona, Spain

DAMIEN BARRAUD, MDMedical ICU, University Hospital of Nancy, Nancy, France

BRIAN CASSERLY, MDAssistant Professor, Division of Pulmonary and Critical Care Medicine, The MemorialHospital of Rhode Island, Pawtucket, Rhode Island

PHIL DELLINGER, MDProfessor of Medicine, University of Medicine and Dentistry of New Jersey, Robert WoodJohnson Medical School; Head, Division of Critical Care Medicine, Cooper UniversityHospital, Camden, New Jersey

KATIA DONADELLO, MDDepartment of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles,Brussels, Belgium

LANCE D. DWORKIN, MDProfessor of Medicine, Division of Kidney Diseases and Hypertension, Rhode IslandHospital, Alpert Medical School of Brown University, Providence, Rhode Island

Contributorsiv

RICARD FERRER, MD, PhDCritical Care Center, Hospital de Sabadell, Sabadell, Spain; CIBER EnfermedadesRespiratorias, Instituto Universitario Parc Tauli, Universidad Autonoma de Barcelona,Barcelona, Spain

HERWIG GERLACH, MD, PhDProfessor and Director of Anesthesiology, Department of Anesthesia, Critical CareMedicine, and Pain Management, Vivantes Clinics Neukoelln; Lecturer, Charite, MedicalFaculty of the Universities of Berlin; Klinik fuer Anaesthesie, Operative Intensivmedizinund Schmerztherapie, Vivantes – Klinikum Neukoelln, Berlin, Germany

SEBASTIEN GIBOT, MD, PhDMedical ICU, University Hospital of Nancy, Nancy, France

STEVEN P. LAROSA, MDAssistant Professor of Medicine, Warren Alpert School of Medicine, Brown University;Division of Infectious Diseases, Rhode Island Hospital, Providence, Rhode Island

MARCEL LEVI, MDDepartment of Vascular Medicine and Internal Medicine, Academic Medical Centre,Amsterdam, The Netherlands

L.J. MARK CROSS, MRCP, PhDCentre for Infection and Immunity, The Queen’s University of Belfast, Belfast, NorthernIreland, United Kingdom

MITCHELL M. LEVY, MDDivision of Pulmonary and Critical Care Medicine, Department of Medicine,Rhode Island Hospital, The Warren Alpert Medical School of Brown University,Providence, Rhode Island

MICHAEL A. MATTHAY, MDCardiovascular Research Institute; Division of Pulmonary and Critical Care, Departmentof Medicine; Department of Anaesthesia, University of California San Francisco,San Francisco, California

MICHAEL MEISNER, Dr Med HabilClinic of Anaesthesiology and Intensive Care Medicine, Staedtisches KrankenhausDresden-Neustadt, Dresden, Germany

OKORIE NDUKA OKORIE, MDAssistant Clinical Professor of Medicine, Florida State University school of Medicine;Department of Critical Care Medicine, Orlando Regional Medical Center,Orlando, Florida

STEVEN M. OPAL, MDProfessor of Medicine, Warren Alpert School of Medicine, Brown University,Providence, Rhode Island; Division of Infectious Diseases, Memorial Hospital,Pawtucket, Rhode Island

RICHARD READ, MDPulmonary Fellow, Rhode Island Hospital, Alpert Medical School of Brown University,Providence, Rhode Island

Contributors v

KONRAD REINHART, Dr Med HabilClinic of Anaesthesiology and Intensive Care Medicine, Friedrich-Schiller-University Jena,Jena, Germany

XAVIER SCHMIT, MDDepartment of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles,Brussels, Belgium

MARCUS SCHULTZ, MDAcademic Medical Centre, Department of Intensive Care Medicine, Universityof Amsterdam, The Netherlands

DOUGLAS SHEMIN, MDAssociate Professor of Medicine, Division of Kidney Diseases and Hypertension,Rhode Island Hospital, Alpert Medical School of Brown University, Providence,Rhode Island

SUSANNE TOUSSAINT, MD, MA, DEAA, EDICKlinik fuer Anaesthesie, Operative Intensivmedizin und Schmerztherapie, Vivantes –Klinikum Neukoelln; Chair, Interdisciplinary Intensive Care Unit, Departmentof Anesthesia, Critical Care Medicine, and Pain Management, Vivantes ClinicsNeukoelln, Berlin, Germany

TOM VAN DER POLL, MDLaboratory for Experimental and Molecular Medicine; Center for Infection and ImmunityAmsterdam, Academic Medical Center, University of Amsterdam, The Netherlands

COREY E. VENTETUOLO, MDDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine,College of Physicians and Surgeons, Columbia University, New York, New York

JEAN-LOUIS VINCENT, MD, PhDProfessor, Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles,Brussels, Belgium