Jay P. Jazul, RPh, MSc., CPS University of Santo Tomas

Faculty of Pharmacy

University of Santo Tomas Faculty of Pharmacy

NON ORGAN-DIRECTED TOXICITY

Jay P. Jazul, RPh, MSc., CPS University of Santo Tomas

Faculty of Pharmacy

University of Santo Tomas Faculty of Pharmacy

CHEMICAL CARCINOGENESIS

University of Santo Tomas Faculty of Pharmacy

University of Santo Tomas Faculty of Pharmacy

University of Santo Tomas Faculty of Pharmacy

University of Santo Tomas Faculty of Pharmacy

University of Santo Tomas Faculty of Pharmacy

University of Santo Tomas Faculty of Pharmacy

University of Santo Tomas Faculty of Pharmacy

University of Santo Tomas Faculty of Pharmacy

Ini$a$on  

University of Santo Tomas Faculty of Pharmacy

Promo$on  

University of Santo Tomas Faculty of Pharmacy

Progression  

University of Santo Tomas Faculty of Pharmacy

University of Santo Tomas Faculty of Pharmacy

Indirect-acting

University of Santo Tomas Faculty of Pharmacy

Indirect-acting

University of Santo Tomas Faculty of Pharmacy

Indirect-acting

University of Santo Tomas Faculty of Pharmacy

Alkylating neutrophiles

University of Santo Tomas Faculty of Pharmacy

Alkyla&on  

University of Santo Tomas Faculty of Pharmacy

Alkyla&on  

University of Santo Tomas Faculty of Pharmacy

Alkyla&on  

University of Santo Tomas Faculty of Pharmacy

Alkyla&on  

University of Santo Tomas Faculty of Pharmacy

Alkyla&on  

University of Santo Tomas Faculty of Pharmacy

Frame-shift Mutations

University of Santo Tomas Faculty of Pharmacy

Mutations

University of Santo Tomas Faculty of Pharmacy

Mutations

University of Santo Tomas Faculty of Pharmacy

Mutation – caused by Radiations

University of Santo Tomas Faculty of Pharmacy

Mutation

University of Santo Tomas Faculty of Pharmacy

Mutation

University of Santo Tomas Faculty of Pharmacy

Mutation

University of Santo Tomas Faculty of Pharmacy

Mutation

University of Santo Tomas Faculty of Pharmacy

University of Santo Tomas Faculty of Pharmacy

Protein structures and nucleic adducts

University of Santo Tomas Faculty of Pharmacy

Protein structures and nucleic adducts

University of Santo Tomas Faculty of Pharmacy

Selected  carcinogenic  polycyclic  HC    

University of Santo Tomas Faculty of Pharmacy

University of Santo Tomas Faculty of Pharmacy

DNA Repair Mechanism by base excision

University of Santo Tomas Faculty of Pharmacy

DNA Repair Mechanism by nucleotide excision

University of Santo Tomas Faculty of Pharmacy

Classes of Genotoxic Carcinogens: 1.  Polyaromatic Hydrocarbons (Benzo(a)pyrene) 2.  Alkylating Agents (Nitrogen mustards) 3.  Aromatic Amines and Amides

University of Santo Tomas Faculty of Pharmacy

Nitrogen mustard (Alkylating agent)

University of Santo Tomas Faculty of Pharmacy

Nitrogen mustard (Alkylating agent)

University of Santo Tomas Faculty of Pharmacy

Alkylating agent

University of Santo Tomas Faculty of Pharmacy

Aromatic Amines

University of Santo Tomas Faculty of Pharmacy

Inorganic Carcinogens

University of Santo Tomas Faculty of Pharmacy

Non Genotoxic Carcinogens

University of Santo Tomas Faculty of Pharmacy

Non Genotoxic Carcinogens

University of Santo Tomas Faculty of Pharmacy

Non Genotoxic Carcinogens

University of Santo Tomas Faculty of Pharmacy

Non Genotoxic Carcinogens

University of Santo Tomas Faculty of Pharmacy

Non Genotoxic Carcinogens

University of Santo Tomas Faculty of Pharmacy

Non Genotoxic Carcinogens

University of Santo Tomas Faculty of Pharmacy

Non Genotoxic Carcinogens

University of Santo Tomas Faculty of Pharmacy

Non Genotoxic Carcinogens

University of Santo Tomas Faculty of Pharmacy

Non Genotoxic Carcinogens

University of Santo Tomas Faculty of Pharmacy

Non Genotoxic Carcinogens

University of Santo Tomas Faculty of Pharmacy

Non Genotoxic Carcinogens

University of Santo Tomas Faculty of Pharmacy

Non Genotoxic Carcinogens

University of Santo Tomas Faculty of Pharmacy

Non Genotoxic Carcinogens

University of Santo Tomas Faculty of Pharmacy

Non Genotoxic Carcinogens

University of Santo Tomas Faculty of Pharmacy

Non Genotoxic Carcinogens

University of Santo Tomas Faculty of Pharmacy

University of Santo Tomas Faculty of Pharmacy

University of Santo Tomas Faculty of Pharmacy