Bioteknologisk FoU på storfe, laks og kjøtt fra bioreaktorer

Centre for Integrative Genetics, UMBStig W. Omholt

Where is biology heading ?

Raffaello Sanzio (1483-1520), Scuola di Atene (1509-1510)

Biology is finally in a Biology is finally in a position to start position to start fulfillingfulfilling AristotleAristotle’’ss(384(384--322 BCE)322 BCE) dreamdreamofof understandingunderstanding thethecausalcausal basis basis ofofbiologicalbiological formform

CIGENE’s mission statement

Contribute to a deep causal understanding of complex genetic characters in fish, plants and animals

for scientific and commercial exploitation

based on a conceptual and methodological integration

of nonlinear system dynamics, mathematical statistics, biological

physics, biological theory, and genomic and phenotypic data.

BridgingBridging thethe genotypegenotype--phenotypephenotype gapgap

NorwegianNorwegian RedRedLimousinLimousin

HolsteinHolstein

JerseyJersey

AngusAngus

HerefordHereford

Sequencing at Baylor College of Sequencing at Baylor College of Medicine (Houston, Texas)Medicine (Houston, Texas)

Started Dec 2003 and to finish 2007 Started Dec 2003 and to finish 2007

Total costs: ~US$51M (USA: 35 M) Total costs: ~US$51M (USA: 35 M)

Norway participates with Norway participates with US$1MUS$1M* * Unique Unique biobankbiobank materialmaterial* Sequencing for * Sequencing for

genetic variationgenetic variation* Competence to exploit * Competence to exploit

the informationthe information

SEQUENCING OF THE BOVINE GENOME SEQUENCING OF THE BOVINE GENOME

Technology transferHigh-throughput quality ensured technology for detection, validation & genotyping of SNPsGene & allele expression analysisDNA-methylation analysis

TechnologyTechnology

MethodologyMethodology

Methodology transferOptimal structure of QTL-mapping populationsApproaches for fine mapping QTLFunctional characterisation of QTL -> identify QTNDetermine LD and haplotype structuresStudy evolutionary history across breeds and genomeImplementation of genome information in breeding programmes

Optimal approach for genome sequencing & experience with wgs

cGRASPConsortium for Genomic Research on All Salmonids ProjectBen KoopWillie DavidsonStig Omholt

Caird RexroadChris SecombesVanya EwartPatricia GallaugherMichael Burgess

Bill DriedzicBob DevlinGraham van AggelenRuth Phillips

Genome BC

Establishment of Consortium for Genomic Research on All Establishment of Consortium for Genomic Research on All SalmonidsSalmonidsProgrammeProgramme (cGRASP), Norwegian University of Life Sciences, October 25-26, 2005

Det finnes for øyeblikket ingen enkeltinvestering

innen norsk marin FoUsom vil ha en større effekt på

norsk akvakultur enn sekvensering av laksens genom

Bestilling til :

Pål Moe Tor B. Næss Truls Hanevold Bjarne Lindstrøm /ØysteinHovdkinn

CIGENECIGENE’’s proof of principle trait:s proof of principle trait:flesh colour in Atlantic salmonflesh colour in Atlantic salmon

Rationale: important complex traitgenetic variationcommercial importanceevolutionary enigma

Proximate understanding of astaxanthin metabolismUltimate understanding of the trait as suchInstrumental and epistemic exploitation of identified polymorphisms

Development of a methane-based industrialscale in vitro production of meat

International consortium established at UMB June 15, 2007 (NorwaInternational consortium established at UMB June 15, 2007 (Norway, y, Netherlands, Germany, Portugal, Belgium, Israel, USA, Netherlands, Germany, Portugal, Belgium, Israel, USA, ………….).)

Academia & Industry (patent pooling)Academia & Industry (patent pooling)National funding, EU funding, National funding, EU funding, PhilantropicPhilantropic fundingfundingDetailed feasibility studies under wayDetailed feasibility studies under wayInterim phase headed by the Norwegian Interim phase headed by the Norwegian University of Life SciencesUniversity of Life Sciences

Those who develop an in vitro production Those who develop an in vitro production technology willtechnology will

by future generations be appraised for their by future generations be appraised for their foresightednessforesightednessguide the development of a sustainable future guide the development of a sustainable future with regard to food production and other related commodities by with regard to food production and other related commodities by use of use of biotechnologybiotechnology

On the local scale On the local scale -- a substantial impact on the development of a a substantial impact on the development of a Norwegian biotech industry and biological research Norwegian biotech industry and biological research

Hans Holbein the Younger (c. 1497-1543): The Ambassadors (1533)