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Submitted by- Priyanka Bhalla Sec-”O” 5028 Lipid Digestion, Absorption & Transportation

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Submitted byPriyanka Bhalla Sec- O 5028

Carbohydrates

Lipids

Proteins

Dietary lipids in mouth

Retain association to form micelles in lumen

Enter enterocytes through diffusion

Stomach (chyme)

Forms free fatty acids by hydrolysis by lipases

Transported to ER for conversion of micelles into triglycerides

Duodenum (large lipid aggregates)

Small lipid droplets emulsification by bile salts

Move to Golgi complex to combine with cholesterol & apoprotiens

No digestion takes place here cause SALIVA contains NO LIPASEDietary lipids in mouth Retain association to form micelles in lumen Enter enterocytes through diffusion

Stomach (chyme)

Forms free fatty acids by hydrolysis by lipases

Transported to ER for conversion of micelles into triglycerides

Duodenum (large lipid aggregates)

Small lipid droplets emulsification by bile salts

Move to Golgi complex to combine with cholesterol & apoprotiens

Dietary lipids in mouth

Retain association to form micelles in lumen

Enter enterocytes through diffusion

Stomach (chyme)

Transported to ER Forms free fatty the food is partly digested In stomach for conversion of acids by hydrolysis a semi fluid mass called to form micelles into by lipases CHYME. But still full triglycerides digestion doesn t take place cause stomach lacks fat-emulsifying agent. Small lipid droplets -emulsification by bile salts Move to Golgi complex to combine with cholesterol & apoprotiens

Duodenum (large lipid aggregates)

Dietary lipids in mouth

Retain association to form micelles in lumen

Enter enterocytes through diffusion

Stomach (chyme)

Gastric juice in duodenum contains gastric lipases which converts some Transported to ER fats into monoglycerides and fatty Forms free fatty for conversion of acids acids by hydrolysis micelles into by lipases triglycerides

Duodenum (large lipid aggregates)

Small lipid droplets -emulsification by bile salts

Move to Golgi complex to combine with cholesterol & apoprotiens

Dietary lipids in mouth

Large lipid aggregates dissociate into small lipid droplets due to Retain association EMULSIFICATION by BILE SALTS to form micelles in which are obtained by Cholesterol lumen Metabolism.

Enter enterocytes through diffusion

Stomach (chyme)

Forms free fatty acids by hydrolysis by lipases

Transported to ER for conversion of micelles into triglycerides

Duodenum (large lipid aggregates)

Small lipid droplets -emulsification by bile salts

Move to Golgi complex to combine with cholesterol & apoprotiens

Dietary lipids in mouth

Retain association to form micelles in lumen

Enter enterocytes through diffusion

Stomach (chyme)

Forms free fatty acids by hydrolysis by lipases

Transported to ER for conversion of micelles into triglycerides

Duodenum (large lipid aggregates)

Small lipid droplets emulsification by bile salts

Move to Golgi complex to combine with cholesterol & apoprotiens

Dietary lipids in mouth

Retain association to form micelles in lumen

Enter enterocytes through diffusion

Stomach (chyme)

Forms free fatty acids by hydrolysis by lipases

Transported to ER for conversion of micelles into triglycerides

Move to Golgi Small lipid droplets complex to combine Duodenum (large -emulsification by bile salts lipid aggregates) Fatty acids retain association with with cholesterol & bile salts and complex with other lipid molecules to apoprotiens form micelles of 4-8 nm diameter

Lipids are broken down by pancreatic lipase and bile, and then diffuse into the Retain association Dietary lipids in ENTEROCYTES. Smaller lipids arein to form micelles mouth lumen transported into intestinal capillaries, while larger lipids are processed by the Golgi and smooth endoplasmic reticulum into lipoprotein chylomicra and Forms free fatty Stomach (chyme)exocytozed into lacteals. acids by hydrolysis by lipases

Enter enterocytes through diffusion

Transported to ER for conversion of micelles into triglycerides

Duodenum (large lipid aggregates)

Small lipid droplets -emulsification by bile salts

Move to Golgi complex to combine with cholesterol & apoprotiens

Steps of Absorption Of LIPIDS.

Move to Golgi complex for conversion of micelles to triglycerides for diff. functions

Finally to ORGANS

Form chylomicrons

Proceed to BLOOD stream

Fuse with cell membrane & released exocytosis

Enter lymphatic system

From the micelles Move to Golgi complex fatty acids , Glycerides,sterols and fat for conversion of Soluble to micellesvitamins reFinally to ORGANS Synthesize diff. triglycerides for in ER to get converted into very small functions Fat molecules called CHYLOMICRONS

Form chylomicrons

Proceed to BLOOD stream

Fuse with cell membrane & released exocytosis

Enter lymphatic system

Gal bladder

Gal bladder

1. Bile salts emulsify Dietary fats in small Interstine, forming Mixed micelles.

Gal bladder

2. Intestinal lipases Degrade triacylglycerols.

Gal bladder

Small intestine

3. Fatty acid and other Breakdown products are taken up By the intestinal mucosa & converted into triglycerols

Gal bladder

Small intestine

Intestinal mucosa Apo C-II 4. Triacylglycerols are Incorporated, with cholesterol & apolipoprotiens into chylomicrons

Gal bladder

Small intestine

Intestinal mucosa Apo C-II

5. Chylomicrons move Through the lymphatic System & blood stream To tissues. Chylomicron

Gal bladder

Small intestine

Lipoprotein lipase 6. Lipoprotein lipase, Activated by apoC-II in The capillary, converts Triacylglycerols to fatty Acids & glycerol Chylomicron

Intestinal mucosa Apo C-II

Gal bladder

7. fatty acids enter cells Small intestine Lipoprotein lipase

Intestinal mucosa Apo C-II Chylomicron

8. Fatty acids are oxidized as Fuel or reesterified for storage. Gal bladder Myocytes & adipocyte

Small intestine

Lipoprotein lipase

Intestinal mucosa Apo C-II Chylomicron