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Bellingham + Stanley
Refractometers Latest Applications
2017
Bellingham + Stanley
A World Leader in
the Manufacture
and Sales of High
Quality
Refractometers
and Polarimeters
ISO 9001-2008
Bellingham + Stanley Ltd. operates a Quality Management System
complying with ISO 9001:2008 (Certificate Number LRQ 0963791)
2
Past and Present…..
3
Company Locations and Representation
4
Bellingham + Stanley
Head Office and Factory, Tunbridge Wells, UK
Bellingham + Stanley USA
Sales & Service for USA, Atlanta, USA
Bellingham + Stanley Authorised Dealers and
Distributors in over 90 Countries
Xylem Sales & Support Centres in every
continent
Markets & Applications
Industry Sectors
6
Industrial
Research, Education
& Government
Beverages
& Sugars
Food
Market Split
7
Food 31%
Beverage 29%
Pharma 22%
Industrial 7%
Education 11%
Research, Education & Government
8
Research Laboratories – commercial & government
Education – Schools, Colleges & Universities
Industrial
9
• Pharmaceutical (USP781/831)
• Chemical
• Petrochemical
• Aviation (fuel, ice inhibitors)
• Hydraulic fluids
• Fire fighting foam
• Surfactants, detergents
• Shampoo
• Starches (paper/textiles)
• Flavours, fragrances
• Essences, oil
• Cosmetics
• Resins & adhesives
• Petrochemicals, waxes
• Lubricants, quenchants
• Biofuels, ethanol, oils
• DEF/AdBlue®, antifreeze
• Seawater
Food
10
• Fruit Ripeness
• Canned Fruits
• Jams, Jellies, Gelatine
• Stabilisers (gum acacia etc.)
• Liquid egg
• Yeast cultures
• Honey
• Edible oils
• Dairy (Yoghurt/milk/butter)
• Ketchup & salsas
• Mustards
• Cooking sauces & soups
• Edible starches
• Confectionary (fondants,)
• Toffee, Taffy
• Cocoa & chocolate
• Brine
Beverages & Sugars
11
• Carbonated Drinks
• Diet Drinks
• Soft Drinks Syrups
• Orange Juice
• Juices General
• Fruit Concentrates
• Lactic Acid Beverages
• Energy Drinks
• Milkshakes
• Flavoured Waters
• Beer Malts
• Ciders
• Wine Alcohol
• Alcopops
• Sugar
• Fructose
• Glucose
• Molasses
• Cane Juice
• Beet Juice
• Corn Syrup
• Coffee
• Sweet Tea
12 © all trademarks recognized
Global Customers
Latest Application
13
Precise Control
14
15
Model RFM330-T RFM340-T
Scale Brix, RI & user Brix, RI & user
Range 0 – 100 Brix
1.32 – 1.58 RI
0 – 100 Brix
1.32 – 1.58 RI
Resolution 0.1 / 0.0001 0.001 / 0.000001 (Selectable to 6 d.p.)
Accuracy 0.1 / 0.0001 0-30 Brix: 0.01 / 0.00002 (1.32-1.38 RI)
30-100 Brix: 0.03 / 0.00004 (1.38-1.58 RI)
Precision
(Reproducibility*)
0.05 / 0.00005 0.004 Brix / 0.000006 RI)
Reading time 4 seconds minimum (dependant on precision required)
Working Temp Range 0°C or 10°C below ambient whichever is greater to 80°C
Automatic Temp Comp Brix, User (to any C)
User Scale Library 20+ pre-programmed scales including HFCS (3), sugar (4), sucrose SG (3),
PHR-MEAN, Urea and more; plus customer programmable user scales via PC.
Interface 3 x USB (A) 1 x USB (B)
1 x Ethernet 1 x Serial (RS232)
Using a traceable homogenous sample under laboratory conditions at 20°C
RFM300-T & RFM300-M Measurement Specification
Production Line Effeciency
16
RFM300-Flow for Tare House
17
Also great for fruit juice and carbonated beverage producers as a funnel
flowcell reduces the need to clean the prism between each sample!
Making Measurement Easy
18
It’s not that simple!
19
RI also depends on temperature
N D
20 N is the symbol for RI
20 C
D = sodium D line (589 nm)
N D
20 = 1.00000
N D
20 = 1.33299
For air,
For water,
When defining RI, the wavelength and temperature are specified:
RI depends on the wavelength of light
Natural light is made up of light of
different colour or wavelength (energy)
Control = Profitability (Case Study)
20
Refractometers ‘The Models’
2017
Eclipse Professional Handheld Refractometers
22
NEW - Easy Read Scales
NEW - Higher resolution
Bright Field of View
Sealed construction
Unique Dribble Feed
Zero adjust (lock)
Ergonomic Design
Anti-roll supports
Push on prism flap
Serial Numbered
Certificate
OPTi Refractometer - Features
23
Single & Dual (Duo) Scale Models
Full & High Range
Robust sealed design
Silicon rubber keypad (not plastic!)
2-second read time
Zero calibration (all models!)
AG Test Mode (unique!)
-HAL- “High Ambient Light” Detection
Temperature Display
Temperature in °C or °F
Simple operation
No operator errors = PRECISION
Portable or laboratory (back-up!)
Certificate by B+S (UKAS/NIST traceable)
OPTi Refractometer – ONE to FOUR
24
OPTi
ONE
Scale: 0-54 Brix
Code: 38-02
• Covers 80% of applications
OPTi
TWO
Scale: 40-95 Brix
Code: 38-33
• Covers syrups and jams at a low price
OPTi THREE
Scale: 0-95 Brix
Code: 38-A1
• Covers Full Brix scale incl. syrups for confectionary
OPTi
FOUR
Scale: 0-83 Brix
Code: 38-34
• Best price covering commonly used Brix scale
Digital Refractometers
25
RFM700-M Series Refractometers
26
Food, beverage, sugar &
other applications with ATC.
Launch: January 2017
RFM700-M Series - Technical Specification
27
Model RFM712 RFM732 RFM742
Scale % Sugar (Brix)
Range 0 – 50 0 – 100 0 – 100
Resolution 0.1 0.1 0.01
Accuracy 0.1 0.1 0.04
Reading time 4.5 4.5 seconds (delay option)
Working Temp Range
5 – 80 C
Automatic Temp Comp
to 20 C
Interface USB A,B Ethernet & RS232
RFM300 Series Refractometers
28
•RFM300-M Series keypad for industrial applications
•RFM300-T Series touchscreen for lab & factory
Instrument Key Feature
29
Flat Prism Dish with sapphire prism Easy application and cleaning
RFM300-M Important Features
30
• Choice of RI accuracy – RFM330-M and RFM340-M
• Intelligent thermal control – 6 sensors
• Peltier temperature control to 70°C
• Rapid temperature response/Stability
• SMART temperature stability checks – sample & calibration
• Measurement Range up to 1.58 RI
• Super flat prism dish for easy cleaning
• Wide measurement beam – non-homogenous samples
• Keypad – membrane for safe factory use
RFM300-Flow Refractometers
31
• Macro flowcell
• Funnel flowcell
• Same spec as RFM300+s
RFM-T Series Refractometers
32
•RFM300-T Series for industrial applications
•RFM900-T Series for high precision applications covering 1.30-1.70 RI
RFM-T Series – New & common features
33
7 “ Touchscreen full colour HD display
USB (A), USA (B), Ethernet & RS232 connectivity
Single low noise, low maintenance, inter-changeable fan
6 decimal place precision – Refractive Index
3 decimal place precision – Brix
Remote diagnostics via Ethernet
Simple USB Back-up & Clone for multi-instr. configuration
Print to Secure PDF
RFM300-T Series for industrial applications with easy-clean prism and
wide beam optics for measuring non-homogenous samples
RFM900-T Series for high precision applications covering a wide RI
range and fully confirming to Pharmacopeia and FDA reg. 21 Part 11
RFM-T Series Common Features
34
Peltier + Air Flow Temperature Control
Intelligent and accurate thermal sensing
Controlled Sample Containment
Network connection via ethernet for
remote lab monitoring
Chemical-Resistant ABS Construction
Strict Password Control
RFID User Identification & Clearance
8000 stored results for tabular display or o/p
Flat prism dish – especially RFM300-T Series
Materials of Construction
35
ABS Housing
Sapphire Prism
316 Stainless Steel Sample Dish
PEEK* Insulation and Spill Barrier
Kalrez* Seals (RFM900-T)
* Chemically-Resistant Plastics
Controlling Sample Temperature to Target Value
36
System of Powerful Peltier Devices
Pumped Air Flow (with single dust filter)
Single low-noise, easy maintenance fan
Configurable on-screen filter change prompt
Rapid Heating/Cooling of Sample
Wide Operating Temperature Range: 10 below ambient to 80 °C
Software Features
37
4 levels of security – NONE-LOW-MEDIUM-HIGH
SMART & other temp. stability checks settings”
“Methods” system for one-touch configuration
Readings Limits Check
Installation Wizards
At least 4 menu ‘languages’
Software - Methods
38
Measuring mode and measuring
specifications can be stored against a
product code/name
Scale and Temperature Compensation
Reading limits/tolerances
Result verification feature
‘Wizard’ to facilitate set-up of methods
Target temperature for readings
Analytical Methods – coffee / D 2140 / pharma
MEAN
Insert an image to help users navigate!
Software - Quality Management
39
Meeting the requirements of FDA 21 CFR Part 11, GLP, HACCP
• Date and Time Recording
• Product and Operator Identifiers:
(Audit Trail*)
• Reading Log:
(not available to highest level of security)
• Calibration Log: (Audit Trail*)
• Calibration Check and Report
• PIN Password Control:
(in accordance with CFR21 Part 11)
Interfaces
-Ethernet connection for LAN
-USB (A) x 3
-USB B connection x 1
-RS232 serial x 1
cables not supplied – generally available
The RS232 is used for GLP printers (dot-matrix
type)
40
Back Plate
Image
RFM300-T Refractometer Series
41
• 1.32-1.58 RI
• Flattest prism
• Wide beam optics
42
Model RFM330-T RFM340-T
Scale Brix, RI & user Brix, RI & user
Range 0 – 100 Brix
1.32 – 1.58 RI
0 – 100 Brix
1.32 – 1.58 RI
Resolution 0.1 / 0.0001 0.001 / 0.000001 (Selectable to 6 d.p.)
Accuracy 0.1 / 0.0001 0-30 Brix: 0.01 / 0.00002 (1.32-1.38 RI)
30-100 Brix: 0.03 / 0.00004 (1.38-1.58 RI)
Precision
(Reproducibility*)
0.05 / 0.00005 0.004 Brix / 0.000006 RI)
Reading time 4 seconds minimum (dependant on precision required)
Working Temp Range 0°C or 10°C below ambient whichever is greater to 80°C
Automatic Temp Comp Brix, User (to any C)
User Scale Library 20+ pre-programmed scales including HFCS (3), sugar (4), sucrose SG (3),
PHR-MEAN, Urea and more; plus customer programmable user scales via PC.
Interface 3 x USB (A) 1 x USB (B)
1 x Ethernet 1 x Serial (RS232)
Using a traceable homogenous sample under laboratory conditions at 20°C
RFM300-T & RFM300-M Measurement Specification
RFM300-T Features
RFM300-T Series – New Opportunities!
-High resolution capacitive touchscreen
-Wide beam optics range – 1.32 to 1.58 RI
-Peltier Temperature Control
-Enhanced Brix performance 0-30 ±0.01 Brix
- Flattest Easy Clean prism
-SMART temperature control
-Dual Display function for Brix & equivalent SG for beverages
43
RFM300-T & RFM300-M - Application Scope
44
RFM300-M/T – wide beam optics and flat prism
• Beverage
• Industrial surfactants & emulsions
• Edible Oils
• Sauces & soups
• Sugar syrups & concentrates
Suitable for harsh industrial applications
• Confectionery
RFM900-T Refractometer Series
45
• 1.30-1.70 RI
• Kalrez® gasket
• Pharma & Petro
RFM900-T Features
RFM900-T Series – New Opportunities!
-High resolution capacitive touchscreen
-Wide range – 1.30 to 1.70 RI
-Peltier Temperature Control
-Up to 6 decimal places RI
-Easy clean prism
-SMART temperature control
46
47
Model RFM960-T RFM970-T
Scale Brix, RI & user Brix, RI & user
Range 0 – 100 Brix
1.30 – 1.70 RI
0 – 100 Brix
1.30 – 1.70 RI
Resolution 0.1 / 0.0001 0.001 / 0.000001 (Selectable to 6 d.p.)
Accuracy 0.1 / 0.0001 0.02 / 0.00002
Precision
(Reproducibility*)
0.05 Brix
0.00005 RI
0.005 Brix
0.000005 RI (6 d.p. RI)
Reading time 4 seconds minimum (dependant on precision required)
Working Temp Range 0°C or 10°C below ambient whichever is greater to 80°C
Automatic Temp Comp Brix, User (to any C)
User Scale Library 20+ pre-programmed scales including HFCS (3), sugar (4), sucrose
SG (3), PHR-MEAN, Urea and more; plus customer programmable
user scales via PC.
Interface 3 x USB (A) 1 x USB (B)
1 x Ethernet 1 x Serial (RS232)
Using a traceable homogenous sample under laboratory conditions at 20°C
RFM900-T Measurement Specification
RFM900-T - Application Scope
48
RFM900-T - very wide measuring range - RI and Temperature
• Research Institutes & academia
• Flavours, Fragrance & Essences
• Chemicals & Industrial
• Pharmaceuticals incl. veterinarian
• Petroleum & derivatives
Suitable for high end laboratory applications
• Healthcare & Cosmetics
Why buy an RFM-T/ M Series Refractometer?
• Capable of six decimal place precision RI (3 d.p. Brix)
• Peltier temperature control
• Ergonomically designed so that any spills are dealt with by its
sloping shape or by the PEEK spill barrier.
• High definition full colour capacitive touchscreen
• RFID user clearance on all models
• USB & Ethernet connectivity
• Almost noise free, maintainable fan
• RFM300-T Series with wide beam optics and flattest easy-clean
prism for “difficult” samples within food, beverage and other
harsh industrial applications. Keypad version available (2017)
• RFM900-T Series wide measuring range 1.30-1.70 RI with
Kalrez® gasket for use in the chemical, petrochemical,
pharmaceutical, flavours & fragrance industries
49
50
QUALITY
MEASUREMENT
Sample
Type
Sample
Preparation
Experimental
Protocol
Instrument
Capability Instrument
Setup
Human
Interaction
(Care)
Interpretation
What makes a good reading?
Certified Reference Materials
Product Training
Jan 2017
52
A UKAS accredited calibration
laboratory
No. 0834
Bellingham + Stanley
A UKAS accredited testing
laboratory
No. 2798
CRM – Verification & Calibration
53
CRM - ILAC-MRA Statement
http://www.bellinghamandstanley.com/ltd/newcalibration/ilac_signatorysearch.html
• The United Kingdom Accreditation Service (UKAS) is
one of the signatories to the International Laboratory
Accreditation Co-operation (ILAC) Arrangement for
the mutual recognition of calibration certificates.
• This means your local accreditation body accepts
UKAS certification as if it were it’s own!
• This is very powerful in terms of persuasion!
54
Water – 1.33299 & 0.00 Brix
Oils – Range 60 - 90 Brix (1.46 to 1.56RI)
Sugars – Range 5 - 60 Brix
AG Fluids – 2.5 - 40 Brix (1.334 to 1.40RI)
Solid Materials* – glass, silica
*Not recommended for digital instruments
CRM – Commercially Available Samples
55
CRM – Example Certificate of Calibration (AG40)
Thank you for your attention Any questions?….
Coffee Break……
Polarimeters
2017
Polarimeters - Past and Present…..
59
Polarimeter Principle
60
Light source
Polariser
Analyser Eye
Tube (sample)
= angle of rotation
D = dextrorotatory (right hand or
clockwise)
L = Laevorotatory (left hand or
counter clockwise).
Polarimeter Scales
61
Chemical and Pharmaceutical Industries -
°Angular Scale (°A)
% Concentration
Sugar and Food Industries -
International Sugar Scale (°Z)
Purity
% Inversion
% Invert Sugar
% Concentration
Temperature
62
Optical Rotation is affected by temperature
Typically 20 °C is used when measuring
optical rotation in Europe (25 °C USP)
Normally samples are stabilised at the
required temperature of measurement
before analysis
Or special ‘temperature controlled
tubes’ are used
ADP 430 - High Resolution / Security Polarimeter
63
ADP450- Patented XPC Technology
64
XPC Technology - Xylem’s patented
on-board Peltier temperature control system
ADP430 / 450 Accuracy
65
Angular (°A)
Sugar (°Z)
Resolution
0.001
±0.001
Accuracy
±0.01
±0.03
Reproducibility
±0.002
±0.006
Validation Documentation (IQ/OQ/PQ)
Software – Quality Management
66
Meeting the requirements of FDA (21 CFR Part 11)*, GLP, ISO...
Date and Time Recording
Product and Operator Identifiers – (Audit Trail*)
Reading Log – (not available to highest level of security)
Calibration Log – (Audit Trail*)
Calibration Check and Report
PIN Password Control (in accordance with 21 CFR Part 11*)
ADP 430 / 450 Methods
67
Similar to RFM900 Series
Specific Rotation & Concentration Methods
Pharmaceutical MEAN Method
Rapid configuration
RFID User Clearance & Tabular navigation thru audit
logs
% Invert Sugar & % Inversion (start – finish) Methods
Standard Display
68
A METHOD system is available in place of the standard MODE
function by internal software switch!
Specific Rotation
69
Reading mode options
70
ADP 430 / 450 Advantages
71
HIGHEST SPEC POLARIMETER – competes with …….
ADP450- Patented XPC Technology
CONFORMS to technical requirements 21 CFR Part 11
CONFORMS to minimum requirements of EP/USP/BP/JP
HIGH SALES POTENTIAL
CONFORMS to technical requirements of ICUMSA
LOWEST price 3-decimal polarimeter in market
Why buy the ADP430 / 450
72
• ADP450- Patented XPC Technology. Peltier temperature control
with easy to fit tubes.
• New Single or Continuous Read Mode Quick identification of
drift, bubbles or erroneous results
• Specific / Concentration Calculation – reduces risk of user error
– faster than manual calculation
• Connection capabilities ensure instrument is ready for future lab
• Storing results / batch / User ID – improving results + traceability
• Above 5 °A it matches performance of many high end
competitors!
ADP 600 Series Polarimeter
73
Our Models…..
ADP600 Series – New Opportunities!
-High Resolution – 4 decimals
-High Accuracy – 3 decimals
-Multiple Wavelength – 6 options (UV/Vis)
-Peltier Temperature Control
-HD Touch-screen display
-Latest Technology Communications
74
ADP600 – USP Nomograms NOT at 589nm
75
Nomogram Wavelength Acceptance
(Specific Rotation)
Metyrosine 546nm 185 195
Iopamidol 436nm -4.6 -5.2
Saquinavir Mesylate 436nm -66.8 -69.6
Finasteride 405nm -56 -60
Lisinopril 405nm -115.3 -122.5
Metaraminol Bitartrate 405nm -31.5 -33.5
Methydopate Hydrochloride 405nm -13.5 -14.9
Timolol Maletate 405nm -11.7 -12.5
Indinavir Sulfate 365nm 122 129
Physostigmine 365nm -236 -246
Ropivacaine Hydrochloride 365nm -210 -255
Vidarabine 365nm -56 -65
Dextromethorphan Hydrobromide 325nm 1%* 1%*
Polarimeter Selection Guide
76
TEMP Accuracy °A @
589nm
Wavelength
Model Peltier ±0.02 ±0.01 ±0.003 325nm 365nm 405nm 436nm 546nm 589nm
ADP430 √ √
ADP450 √ √
ADP610 √ √ √
ADP620 √ √ √ √
ADP622 √ √ √ √
ADP640 √ √ √ √ √ √
ADP650 √ √ √ √ √ √ √
ADP660 √ √ √ √ √ √ √ √
ADP600 Peltier Performance
77
Sample Temp Set Temp Stabilisation Time
35°C 20°C 4 minutes
5°C 20°C 5 minutes
22°C (ambient) 20°C 2 minutes
The speed and efficiency of the Peltier system enables the set point
temperature to be reached in the quickest time possible, typically within two
minutes for a 10ml sample in a glass tube at or around ambient temperature.
Above are the extremes!
Read More! FAQ-ADP-029
Don’t forget – pharmacopeia only requires an accuracy/stability to ±0.5°C
Touchscreen Display…..
- Display (Graphic User Interface)
- High definition 7.4” touch-screen
- 480 x 800 pixel LED
- Backlit LCD
- Clearly defined
- Colour coded menu structure
- Easy to use
- Sharp contrast
- Finger and Glove friendly
78
Communication & Connections
-Ethernet connection for LAN
-USB (A) x 4
-USB B connection x 1
-RS232 serial x 1
- (cables not supplied – generally available)
79
Our Models…..
ADP600 Series Polarimeters:
-ADP600 Models, Wavelengths & Order Codes
-ADP610 = 589nm (order code 37-61)
-ADP620 = 546 & 589nm (order code 37-62)
-ADP622 = 365 & 589nm (order code 37-63)
-ADP640 = 405, 436, 546 & 589nm (order code 37-64)
-ADP650 = 365, 405, 436, 546 & 589nm (order code 37-65)
-ADP660 = 325, 365, 405, 436, 546 & 589nm (order code 37-66)
- Additional wavelengths can be added at point of order (not retrospectively)
80
Common Features…..
Measurement Specifications
- Scales = Angular degrees + user definable (see below)
- Ranges = ±89 (-355° to +355° Angular - via Method selection)
- Resolution = 0.001/0.0001° Angular (Specific Rotation 9999.9999, concentration
0-99.99999 via Method selection)
- Reproducibility = 0.002° Angular
- Accuracy = ±0.003° Angular
- Other scales/Methods - User definable scales via Methods for Specific Rotation,
Concentration, Inversion (A-B) etc. Batch MEAN Method for Pharmacopoeia and GLP
- Automatic Temperature Compensation (ATC) = None, sugar (ICUMSA), quartz, user defined
- Reading Time (seconds) = 15 – 60 (range specific)
- Working Temperature Range = 15 to 35 °C
- Interface = 4 x USB (A), 1 x USB (B), 1 x RS232 1 x Ethernet
- Ambient Humidity Range = <90% RH
81
Why buy an ADP600 Series Polarimeter?
• Meets ALL requirements of Pharmacopeia (BP/EP/USP/JP)
• UV/Vis capability – 325nm offered only by 2 others!
(RESEARCH)
• Air Peltier System – Allows the customer to use ANY tube
• Connections on the side – Easy Access
• PDF / external print capabilities
• Option to upgrade wavelengths at a later date
• Designed for easy maintenance – customer able to change
lamp with no training
• Facilitates operation in FDA controlled environment (21 CFR
Part 11)
• Un-paralleled technical support from B+S
• Over all – it’s EASY to use 82
Certified Reference Materials
Product Training
Jan 2017
84
CRM - ILAC-MRA Statement
http://www.bellinghamandstanley.com/ltd/newcalibration/ilac_signatorysearch.html
• The United Kingdom Accreditation Service (UKAS) is
one of the signatories to the International Laboratory
Accreditation Co-operation (ILAC) Arrangement for
the mutual recognition of calibration certificates.
• This means your local accreditation body accepts
UKAS certification as if it were it’s own!
• This is very powerful in terms of persuasion!
85
Water – 1.33299 & 0.00 Brix
Oils – Range 60 - 90 Brix (1.46 to 1.56RI)
Sugars – Range 5 - 60 Brix
AG Fluids – 2.5 - 40 Brix (1.334 to 1.40RI)
Solid Materials* – glass, silica
*Not recommended for digital instruments
CRM – Commercially Available Samples
Sugar – 100 °Z point (34 °A)
Thermal Block for temp. sensor
Quartz Plates: 15 °Z (5 °A), 100 °Z (34 °A), -30 °Z (-10.85 °A)
Quartz Compensation
Infinite Shelf Life (typically 3-year check)
Traceable to PTB
UKAS Certificate Code 90-803 (589.44nm)
UKAS Certificate Code 90-805 (other wavelengths)
CRM – Polarimeters & Saccharimeters
CRM – Polarimeters & Saccharimeters
‘NEW’ multi pack of QCP
plates, can hold up to 3
quartz control plates.
Certification can be carried
out from 546nm to 900nm.
Thank you for your attention Any questions?….
