Author index

Akeroyd, F. M., Two Year Doctorates(Letterto the Editor) 241

Akers, H., Peppy esters (Questions andAnswers) 391

Akers, H. A. and Dromgoole, E. V.,Ornithine isn't just for the birdsanymore! (50 Years Ago) 156

Albrecht, P., see Ourisson, G. 236Aliperti, G., see Schlesinger, M. J. 222Anderson, J. M. and Andersson, B., The

architecture of photosyntheticmembranes: lateral and transverseorganization 288

Andersson, B., see Anderson, J. M. 288Apps, D. K., The uptake of amines by

secretory granules 153Araya, A., see Litvak, S. 361Atkinson, T.,Hammond, P. M., Hartwell,

D. R., Scawen, M. D., Sherwood, R.F. and Price, C. P., The application ofmicrobial enzymes in drugassays 126

Auhagen, E., Co-carboxylase (SO YearsAgo) 225

Baker, C. G., The Ludwig Institute forCancer Research 44

Baker, J. R., Referees' reports 241Balasubramanian, R., The origin of the

genetic apparatus (Letter to theEditor) 9

Beinert, H. and Massey, V., PeterHemmerich,1929-1981(Obituary) 43

Bennett, J., Sic transit peptide (JournalClub) 269

Berg, O. G., Winter, R. B. and von Hippel,P. H., How do genome-regulatoryproteins locate their DNA targetsites? 52

Bernardi, G., The origins of replication ofthe mitochondrial genome ofyeast 404

Bernards. A., Transposable genes forsurface glycoprotcins intrypanosomes 253

Blevins, D. G., see Reynolds,P. H. S. 366

Bloch, K., The structure of cholesterol and

of the bile acids (50 Years Ago) 334Blundell, T., Trust and gullibility in

science (Opinion) 352Boland, M. J., see Reynolds,

P. H. S. 366Borek, E., What is true ofcoli . . . (Letter

to the Editor) 280Borek, E., Congress as research director

(Opinion) 313Brady, F. 0., The physiological function of

metallothionein 143Branton, D., see Ungewickell, E. 358Brautigan, D. L., see Fischer, E. H. 3Bres, P. and Chambon, L., The Pasteur

Institutes worldwide 83Brinster, R. L. and Palmiter, R. D.,

Induction of foreign genes inanimals 438

Brot, N. and Weissbach, H., Thebiochemistry of methionine sulfoxideresidues in proteins 137

Brunori, M. and Wilson, M. T.,Cytochrome oxidase 295

Bu'Lock, J. D., All in the genes?(Opinion) 422

Burke, B., Co-operation between T and Blymphocytes (Journal Club) 80

Button, E. E., see KUll, F. J. 317

Cantino, M. E. and Hutchinson, T. E.,Electron probe X-ray microanalysis(Emerging Techniques) 132

Capaldi, R. A., Structure of intrinsicmembrane proteins 292

Carlile, M., Prokaryotes and eukaryotes:strategies and successes 128

Carlile, M., Coding capacity ofyeastmitochondrial DNA (Letter to theEditor) 281

Chambon, L., see Bres, P. 83Chapman, D., G6mez..Femandez, J. C.

and Goni, F. M., The interaction ofintrinsic proteins and lipids inbiomembranes 67

Chater, K. F. and Hopwood, D. A., Genecloning in non-enteric bacteria 445

Chen, M., Cancer-suppressive factor 364Chiba, H., see Sasaki, R. 140Chibnall, C., The isolation of asparagine

and glutamine from proteins (50Years Ago) 191

Chisholm, R., Gene amplification duringdevelopment (Journal Club) 161

Chisholm, R. L., Methylation anddevelopmental regulation of geneexpression (Journal Club) 421

Christensen, H. N., Efflux used as a fadword? (Letter to the Editor) 134

Cohen, J. S. and Wlodawer, A.,Diffraction and NMR studies ofproteins: an uneasy alliance 389

Colman, A., CellS that secrete foreignproteins 435

Conn, E. E., seeH6sel, W. 219Conrad, G. W., Authorship and

responsibility in scientificpublications and manuscript reviews(Opinion) 167

Cook-Deegan, R. M., The Researcher as aCongressiona Director (Letter to theEditor) 434

Cori, 0., see Vicuna, R. 319Craig, S. W., see Pollard, T. D. 55Craig, S. W. and Pollard, T. D.,

Actin-binding proteins 88Crespi, R. S., Current issues in patent

law 423

Day, H. G., E. V. McCollum andmagnesium in nutrition (50 YearsAgo) 112

Dean, D., see Nomura, M. 92de Crombrugghe, B. and Pastan, 1.,

Structure and regulation of a collagengene 11

Dromgoole, E. V., see Akers, H. A. 156Dunn, M. 1., see Rice-Evans, C. A. 282Dynan, W. and Tjian, R., Transcription

enhancer sequences: a novelregulatory element (JournalClub) 124

East, 1. J., see Todd, P. E. E. 212Edsall, J. T., George Scatchard, John G.

Kirkwood, and the electricalinteractions of amino acids andproteins (50 Years Ago) 414

Engvall. E., see Ruoslahti, E. 188

Enyedi, A., see Gardos, G. 242Evans, L, see Wilkie, D. 147

Fairlamb, A., Biochemistry oftrypanosomiasis and rationalapproaches to chemotherapy 249

Fee, J. A., Is superoxidc important inoxygen poisoning? 84

Felbeck, H. andSomero, G. N., Primaryproduction in deep-sea hydrothermalvent organisms: roles ofsulfide-oxidizing bacteria 201

Fischer, E. H. and Brautigan, D. L., Aphosphatase by any other name: fromprosthetic group removing enzyme tophosphorylase phosphatase 3

Fonnan, H. J. and Naugaard, N.,Superoxide toxicity (Letter to theEditor) 279

Freeman, A., see Katachalski-Kattir,E. 427

Friedman, M. J., The biochemical ecologyof intracellular parasites 332

Froton, J. F., The carbobenzoxy method ofpeptide synthesis (50 Years Ago) 37

Gardos, G., Sarkadi, B. and Enyedi, A.,Control of Ca2+ pumps (Letter to theEditor) 242

Garel, J-P., The silkworm, a model formolecular and cellularbiologists 105

Garrett, R. A. and Noller, H. F.,Controlling ribosomal 5S RNAsynthesis: further dual nucleicacid-binding proteins (JournalClub) 309

Garrett, R. A. and Woolley, P., Identifyingthe peptidyl transferase centre(Journal Club) 3&5

Garrett, R. A., see Prince, J. B. 79, 280Gausing, K., Regulation of ribosome

synthesis in E. coli 65Geiger, B., Proteins related to the red-cell

cytoskeleton in non-erythroid cells(Journal Club) 388

Geuns, J. M. C., Plant steroid hormones­what are they and what do they do?(Open Question) 7

Gillies, R. J., Calcium, calmodulin andcAMP and the control of cellularproliferation (Journal Club) 233

Gillies, R. J., The binding site for aldolaseand G3PDH in erythrocytemembranes (Journal Club) 41

Glassy, M. C., A chemical and biologicalprofile of HLA-DR (la-like)antigens 286

Goeldner, M. P., Hirth, C. G., Kieffer, B.and Ourisson, G., Photosuicideinhibition - a step towards specificphotoaffinity labelling 310

G6mez..Femandez, J. C., see Chapman,

D. 67Goiii, F. M., see Chapman, D. 67Goodman, R. M., see Howarth,

A. J. 180Gough, N., ... And even more

complexity in the humanimmunoglobulin Alight-chain genelocus (Journal Club) 82

Gough, N., Gene conversion and thegeneration of antibody diversity(Journal Club) 307

Gough, N., Immunoglobulin genes caughton the hop (Journal Club) 163

Greaves, M., see Newman, R. 397Grishin, E. V., see Ovchinnikov,

Y. A. 26Groner, B. and Hynes, N. E., Long

terminal repeats provide regulatorysignals at the ends of retroviralgenes 400

Gunson, D. E., see Prince, R. C. 239

Hall, G. C., see Jensen, R. A. 177Halliwell, B., Superoxide and

superoxide-dependent formation ofhydroxyl radicals are important inoxygen toxicity 270

Hammond, P. M., see Atkinson, T. 126Hartwell, D. R., see Atkinson, T. 126Hastings, J. W., see Wilson, T. 158Haugaard, N., see Forman, H. J. 279Hayman, E., see Ruoslahti, E. 18&Heidelberger, M., Pneumococcal

polysaccharides and their significance(50 Years Ago) 261

Hemker, H. C. andZwaal, R. F. A.,Heterogeneous biocatalysis in thegeneration of thrombin 378

Henschen, A., see Jolles, P. 325Hers, H.-G., Hue, L. and VanSchaftingen,

E., Fructose, 2,6-bisphosphate 329Hirth, C. G., see Goeldner, M. P. 310Hobden, A. N., see Harford, S. 450Hopwood, D. A., see Chater, K. F. 445Hosel, W. and Conn, E. E., The aglycone

specificity of plantf3-glycosidases 219

Howarth, A. 1. and Goodman, R. M., Plantviruses with genomes ofsingle-stranded DNA 180

Hue, L., see Hers, H.-G. 329Hunter, T., Phosphotyrosine - a new

protein modification 246Hutchinson, T. E., see Cantina,

M. E. 132Hynes, N. E., see Groner, B. 400

Ikura, K., see Sasaki, R. 140Ish-Horowicz, D., Induction of virus

transcription by steroid hormones(Journal Club) 80

Itakura, K., Chemical synthesis ofgenes 442

Ito, Y., Countercurrent chromatography(Emerging Techniques) 47

Jackson, D. A. and Patel, S. B., Nuclearorganization - does the sub-structureplaya crucial role? (OpenQuestion) 272

Jaenicke, L., Volvox biochemistry comesof age 61

Jaynes, J. M. and Vernon, L. P., Thecyanelle of Cyanophora paradoxa:almost a cyanobacterialchloroplast 22

Jencks, W. P., Peppy esters (Questions andAnswers) 391

Jensen, R. A. and Hall, G. c.,Endo-oriented control of pyramidallyarranged metabolicbranchpoints 177

Jolll:s, P. and Henschen, A., Comparisonbetween the clotting of blood andmilk 325

Jones, M. N., The' internal pressure' in cellmembranes (Letter to the Editor) 51

Kabat, E. A., Life in the laboratory - andoutside 204

Karlson, P., Ectohorrnones andphytohorrnones (50 Years Ago) 382

Karlson, P., The biological role of nucleicacids (l00 Years Ago) 302

Kasal, C., see Perez,.Polo, J. R. 59Katchalski-Katzir, E. and Freeman, A.,

Enzyme engineering reachingmaturity 427

Kell, D. B., Bacteria that are resistant touncouplers - what can they tell us?(Journal Club) I

Kell, D. B., Enzymes as energy 'funnels'?(Journal Club) 349

Kell, D. B., A rose by any other name(Journal Club) 420

Kelley, P. M., see Schlesinger, M. J. 222Kelly, G. J., How widespread are

cyanide-resistant mitochondria inplants? (Journal Club) 233

Kelly, G. 1., Light-mediated activation ofenzymes in photosynthetic cells(Journal Club) 81

Kerscher, L. and Oesterhelt, D., Pyruvate:ferredoxin oxidoreductase - newfindings on an ancient enzyme 371

Khan, M. I., see Surolia, A. 74Kieffer, B., see Goeldner, M. P. 310Kilejian, A., Surface membranes of

malarial parasites 5Kimberlin, R. H., Reflections on the nature

of scrapie agent 392King, J. and Torriani, A., Science and

politics in Chile (Letter to theEditor) 208

Klein, D. C. and Namboodiri, M. A. A.,Control of the circadian rhythm in

pineal serotonin N .acetyltransferaseactivity: possible role of proteinthiol:disulfide exchange 98

Kraehenbuhl, J.P., see KUhn, L. C. 299Krebs, H. A., The discovery of the

ornithine cycle of urea synthesis (50Years Ago) 76

KUhn, L. C. and Kraehenbuhl, J.P., Thesacrificial receptor - translocation ofpolymeric IgA across epithelia 299

Kull, F. J.. Vellekamp, G. J. and Button,E. E., Ionic strengths and enzymeactivities (Letter to the Editor) 317

Kurland, C. G., Molecular biology - analternative view (Opinion) 46

Lane, L. C., Making electrophoresisbuffers (Letter to the Editor) 242

Leach, S. I., see Todd, P. E. E. 212Leigh, J. S., see Prince, R. C. 239Le Rudulier, D. and Valentine, R. C.,

Genetic engineering in agriculture:osmoregulation 431

Litvak, S. and Araya, A., Primer transferRNA in retroviruses 361

Lodish, H. F., Validity of scientific data­the responsibility of the principalinvestigator (Opinion) 86

Lonn, U., DNA replication in polytenechromosomes 24

Luzio, J. P., seeStanlcy, K. K. 145

Maciag, T., Purification of humanplatelet-derived growth factor(Journal Club) 270

Maciag, T., The human epidermal growthfactor receptor.kinase complex(Journal Club) 197

Massey, V., see Heinert, H. 43Mayhew, S. G. and O'Connor, M. E.,

StrUcture and mechanism of bacterialhydrogenase 18

McDonald, G. G., see Prince, R. C. 239McDonald, P., Silage fermentation 164Mcintyre, N., see Owen, I. S. 95McKay, R.; How maJiy genes are needed

for touch? (Journal Club) 162Meyer, D. 1., The signal hypothesis - a

working model 320Michell, R. H., A link between lithium,

lipids and receptors? (JournalClub) 387

Michell, R. H., Two sites for Ca2+ controlin one Ca2+ pump (JournalClub) 123

Miller, A., Molecular packing in collagenfibrils 13

MlIlller, 1. M., see Palmer, J. M. 258Morrison, I. F., The slow-binding and

slow, tight.binding inhibition ofenzyme-catalysed reactions 102

Nagley, P. and Novitski, C. E., Coding

capacity of yeast mitochondrial DNA(Letter to the Editor) 281

Namboodiri, M. A. A., see Klein,D. C. 98

Narita, H., see Sasaki, R. 140Newby, A. c., see Stanley, K. K. 145Newman, R., Schneider, c., Sutherland,

R., Vodinelich, L. and Greaves, M.,The transferrin receptor 397

Nierhaus, K. H. and Rheinberger, I.,tRNA binding to ribosomes-two sitesor more (Letter to tbe Editor) 280

Noller, H. F., see Garrett, R. A. 309Nomura, M., Dean, D. and Yates, 1. L.,

Feedback regulation of ribosomalprotein synthesis in Escherichiacoli 92

Novitski, C. E., see Nagley, P. 281

O'Connor,M. E., seeMayhew,S.G. 18Oesterhelt. D., see Kerscher, L. 371Ogren, W. L., see Somerville, C. R. 171Ohlrogge,1. B., Fatty acid synthetase:

plants and bacteria have similarorganization (Journal Club) 386

Ohlrogge, I. B., Platelet activating factordoes more than activate platelets(Journal ClUb) 235

Ourisson, G., Albrecht, P. and Rohmer,M., Predictive microbial biochemistry- from molecular fossils to procaryoticmembranes 236

Ourisson, G., see Goeldner, M. P. 310Ovchinnikov, Y. A. and Grishin, E. V.,

Scorpion neurotoxins as tools forstudying fast sodium channels 26

Owen,1. S. and McIntyre, N., Plasmalipoprotein metabolism and lipidtransport 95

Pain, D., see Surolia, A. 74Palmer, J. M., Ample evidence for

cyanide-resistant oxidases in plants(Letter to the Editor) 357

Palmer, I. M. and MlIlller, 1. M.,Regulation ofNAD(P)Hdehydrogenases in plantmitoohondria 258

Palmiter, R. D., see Brinster, R. L. 438Pastan, 1., see de Crombrugghe, B. lJPatel, S. B., see Iackson, D. A. 272Pedrali-Noy, G., see Spadari, S. 29Perez-Polo, I. R. and Kasal, C., Circadian

rhythms in vitro 59Pierschbao;;hcr, M., see Ruoslahti, E. 188Pollard, T. D., and Craig, S. W.,

Mechanism of actinpolymerization 5S

Pollard, T. D., see Craig, S. W. 88Poole, R. K., The oxygen reactions of

bacterial cytochrome oxidases 32Price, C. P., see Atkinson, T. 126Prince, I. B. and Garrett, R. A., tRNA

binding to ribosomes - two sites ormore? (Ioumal Club) 79

Prince, J. B. and Garrett, R. A., !RNAbinding to ribosomes - two sites ormore (Letter to the Editor) 280

Prince, R. C., Gunson, D. E., Leigh, 1. S.and McDonald, G. G., Thepredominant form of fructose is apyranose, not a furanose ring(Textbook Errors) 239

Putney, S., see Schimmel, P. 209

Racker, E. , Otto Warburg at a turning pointin 1932 (50 Years Ago) 448

Randall, D. D., see Reynolds,p, H. S. 366

Reich, I. G., The value of kinetic methods(Letter to the Editor) 434

Reynolds, P. H. S., Boland, M. 1.,Blevins, D. G., Randall, D. D. andSchubert, K. R., Ureide biogenesis inleguminous plants 366

Rheinberger, J., see Nierhaus, K. H. 280Rice-Evans, C. A. and Dunn, M. J.,

Erythrocyte deformability anddisease 282

Robinson, B. R., Inborn errors ofmetabolism leading tolacticacidemia 151

Rocks, B. and Riley, C. , Flow injectionanalysis (EmergingTechniques) 315

Rohmer, M., See Ourisson, G. 236Romeo, D., Transmembrane signalling and

modulation of neutrophilbehaviour 408

Ruoslahti, E., Pierschbacher, M.,Hayman, E. G. and Engvall, E.,Fibronectin: a molecule withremarkable structural and functionaldiversity 188

Rutherford, C. L., Taylor, R. D., Merkle,R. K. and Frame, L. T., Cellularpattern formation: Dictyoste!iumdiscoideum as a system for abiochemicai approach 108

Sala, F., see Spadari, S. 29Sarkadi, B., see Gardos, G. 242Sasaki, R., !kura, K., Nanta, H.,

Yanagawa, S. and Chiba, H.,2,3.Bisphosphoglycerate in erythroidcells 140

Scawen, M. D., see Atkinson, T. 126Schekman, R., The secretory patbway in

yeast 243Schimmel, P., Putney, S. and Starzyk, R.,

RNA and DNA sequence recognitionand structure-function of arninoacyltRNA synthetases 209

Schlesinger, M. I., Aliperti, G. andKelley, P. M., The response of cells to

heat shock 222Schmidt, M. F. G., Acylation ofproteins­

a new type of modification ofmembrane glycoproteins 322

Schneider, C., see Newman, R. 397Schramm, V. L., Metabolic regulation:

could Mn" be involved? 369Schubert, K. R., see Reynolds,

P. H. S. 366Searcy, D. G., Thermoplasma: a

primordial cell from a refusepile 183

Shapiro, S., The value of shared authorship(Letter to the Editor) 319

Sherratt, D. J., see Arthur, A. K. 121ShetWood, R. F., see Atkinson, T. 126Shimizu, M., Origin of the genetic code

(Leiter to the Editor) 357Shive, J., see Shuster, C. W. 356Shuster, C. W. and Shive, J., Does the

form of stored energy correlate withthe mobility of an organism?(Question and answer) 356

Siekevitz, P., Scientists and judgment(Opinion) 200

Sluytennan, L. A. AE.,Chromatofocusing: a preparativeprotein separation method (EmergingTechniques) 168

Smith, M., Site-directedmutagenesis 440

Somero, G. N., see Felbeck, H. 201Somerville, C. R. and Ogren, W. L.,

Genetic modification ofphotorespiration 171

Spadari, S., Sala, F. and Pedrali-Noy, G.,Aphidicolin: a specific inhibitor ofnuclear DNA replication ineukaryotes 29

Srere, P. A., The structure of themitochondrial innermembrane-matrix compartment 375

Stanley, K. K., Newby, A. C. and Luzio,J.P. Whatdoectoenzymesdo? 145

Starzyk, R., see Schimmel, P. 209Suralia, A., Interaction ofprotein A with

the domains of Fc fragment (Letter tothe Editor) 318

Surolia, A., Pain, D. and Khan, M. I.,Protein A: nature's universalanti-antibody 74

Sutherland, R., see Newman, R. 397Szabo, P. and Ward, D. C., What's new

with hybridization in situ? (Emerging

Techniques) 425

Tanner, M. J. A., Red cell invasion by themalarial parasite (Journal Club) 231

Tartakoff, A. M., Simplifying the complexGolgi 174

Tartakoff, A. M., The one and onlymissing link in protein secretion?(Journal Club) 125

Tauber, A. 1., The human neutrophiloxygen armory 411

Thompson, R. J., Spotting musculardystrophy (Journal Club) 2

Thompson, R. J., ai-Antitrypsindeficiency - the European 'sicIde-celIanaemia' (Journal Club) 349

Thompson, R. J., Are monoclonalantibodies the end ofradioimmunoassay? (JournalClub) 419

Tjian, R., see Dynan, W. 124Todd, P. E. E., East, I.J. andLeach,S. J.,

The immunogenicity and antigenicityofproteins 212

Torrianai, A., see King, J. 208Traut, T. W., UMP synthase: the

importance of quaternary structure inchanneling intermediates 255

UlIu, E., The human Alu family ofrepeated DNA sequences 216

UngewickelI, E. and Branton, D.,Triskelions: the building blocks ofcIathrin coats 358

Valentine, R. C., see Le RuduIier,D. 431

Van Leuven, F., Humana2-macroglobulin: structure andfunction 185

Van Schaftingen, E., see Hers, H-G. 329Vellekamp, G. J., see KulI, F. J. 317Vernon, L. P., see Jaynes, J. M. 22Vicuna, R. and Cori, 0., Chilean

biochemistry (Letter to theEditor) 319

Vodinelich, L., see Newman, R. 397von Hippel, P. H., see Berg, O. G. 52

Wang, C. C., Current problems inanti-parasite chemotherapy 354

Ward, D. C., see Szabo, P. 425Watson, M., Replication control and

incompatibility in bacterial plasmids

(Journal Club) 198Weinberg, R. A., Oncogenes of human

tumor cells 135Weissbach, H., see Brot, N. 135Westerhoff, H. V., Fusion of

biomembranes by macroscopicelectric fields (Journal Club) 199

Westerhoff, H. V., NMR sheds more lighton ion transport (Journal Club) 232

Westerhoff, H. V. Should irreversiblethermodynamics be applied tometabolic systems? - Yes. Kineticsalone are impracticable (DiscussionForum) 275

Whelan, W. J., see Wood, H. G. 351Wieland, F., Are sulfated cell surface

glycoproteins involved in the controlof cell differentiation? (JoumalClub) 308

Wilkie, D. and Evans, 1., Mitochondriaand the yeast cell surface: implicationsfor carcinogenesis 147

Williams, J., The evolution of transferrin(Open Question) 394

Williamson, A. R., see Harford, S. 450Wilson, D. F., Should irreversible

thermodynamics be applied tometabolic systems? - Not in mostcases (Discussion Forum) 275

Wilson, M. T., see Bcunori, M. 295Winchester, B., Animal models of human

genetic diseases 7IWinter, R. B., see Berg, O. G. 52Wlodawer, A., see Cohen, J. S. 389Wolf, D. H., Proteinase action in vitro

versus proteinase function in vivo:mutants shed light on intracellularproteolysis in yeast 35

Wood, H. G. and Whelan, W. J. , Freedomto meet 351

Woolley, P., see Garrett, R. A. 385

Yanagawa, S., see Sasaki, R. 140Yates, J. L., see Nomura, M. 92

Ziemiecki, A., The cellular homologue ofthe transforming gene of Roussarcoma virus (Journal Club) 42

Zirnrnern, D., Do viroids and RNA virusesderive from a system that exchangesgenetic information (OpenQuestion) 205

Zwaal, R. F. A., see Hemker, H. C. 378