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MAGNESIUM RESEARCH &
ALIVIO PRODUCT SUPPORT
A Summary of Research Findings
MAGNESIUM DEFICIENCY
THE IMPORTANCE OF MAGNESIUM TO HUMAN NUTRITION BY MICHAEL B. SCHACHTER M.D., F.A.C.A.M.
Abstract
Magnesium is an extremely important and valuable mineral, whose value for good health is just being recognized by conventional physicians. Virtually, all chemical reactions in the body require an enzyme system to help the biochemical reaction take place. An enzyme system generally consists of three parts. They are a specific protein molecule, another smaller organic compound, which is often a vitamin, such as pyridoxine or vitamin B6, and finally a charged mineral, such as zinc, copper, manganese or magnesium. Magnesium is a critical co-factor in more than 300 enzymatic reactions in the human body. Each mineral when dissolved in fluids has a characteristic electrical charge, called its valance. Minerals with a charge of plus 1, or univalent cations, include sodium and potassium. Minerals with a charge of plus 2, or divalent cations, include copper, zinc, manganese and magnesium. Potassium and magnesium are the most abundant cations found within the cells of the body with magnesium being the most abundant divalent cation. In the USA, magnesium supplementation is dramatically under-utilized by conventional physicians and is more important in patient therapy than most physicians realize. There are over 200 published clinical studies documenting the need for magnesium. In fact, at the 1992 American College of Cardiology annual meeting, a limited biography on magnesium was the most often requested item at the National Council on Magnesium and Cardiovascular booth. Up until recently, conventional medicine's interest in magnesium has been only by obstetricians, who have used injectable magnesium sulfate extensively in the treatment of high blood pressure and pre-eclampsia and eclampsia of pregnancy. But, recently conventional physicians have become interested in treating patients with acute heart attacks, chronic cardiovascular disease, heart arrhythmias, diabetes, asthma, chronic fatigue syndrome and many other disorders. http://www.mbschachter.com/importance_of_magnesium_to_human.htm
Why 80% of Us Are Deficient In Magnesium Dr. Mark Sircus
Abstract
Magnesium deficiency is often misdiagnosed because it does not show up in blood tests – only 1% of the body's magnesium is stored in the blood.
Most doctors and laboratories don't even include magnesium status in routine blood tests. Thus, most doctors don't know when their patients are deficient in magnesium, even though studies show that the majority of Americans are deficient in magnesium.
Consider Dr. Norman Shealy's statements, "Every known illness is associated with a magnesium deficiency" and that, "magnesium is the most critical mineral required for electrical stability of every cell in the body. A magnesium deficiency may be responsible for more diseases than any other nutrient." The truth he states exposes a gaping hole in modern medicine that explains a good deal about iatrogenic death and disease. Because magnesium deficiency is largely overlooked, millions of Americans suffer needlessly or are having their symptoms treated with expensive drugs when they could be cured with magnesium supplementation.
http://www.greenmedinfo.com/blog/magnesium-deficiency-symptoms-and-diagnosis
TRANSDERMAL MAGNESIUM THERAPY
Transdermal Magnesium Therapy Dr. Mark Sicus, Ac., OMD, DM (P),
Abstract
Most of us are very familiar with taking medicines and supplements orally though there are also many medicines now given transdermally (direct absorption through the skin). Popular examples are nicotine patches, hormone patches and many others. The advantages of transdermal absorption are varied including the direct application of medicine over an area of pain, the more rapid entry into the bloodstream, bypassing the digestive tract where it can be reduced in its effect by enzyme and acid actions, and increased absorption and bioavailability. In the case of magnesium it can reduce the common side effect of diarrhea that is the single-most limiting factor to increasing our magnesium levels sufficiently. Taken orally, only 30-40%% of the magnesium is actually absorbed possibly less Dr. Jay Cohen, MD, states that "When you take magnesium tablets or capsules, your body absorbs only 30 percent of the magnesium they contain. With many top-selling products, absorption is much less, as little as 10 percent."
Repletion of the deficiency with transdermal magnesium mineral therapy is the ideal way of administering magnesium in medically therapeutic doses. Transdermal medicine is ideal for pain management as well as sports, pediatric, and geriatric medicine. In fact it is one of the best ways of administering medicines quickly and effectively. Transdermal methods of delivery are widely used because they allow the absorption of medicine directly through the skin. Gels, emulsion creams, sprays, and lip balm stick applicators are easy to use and are effective in getting medicine into the bloodstream quickly. Traditional methods of administering medicine such as tablets or capsules get watered down and become less effective due to stomach acids and digestive enzymes before they eventually get into the bloodstream. Because of high concentrations of binders, coupled with high compaction pressures used by some pill manufacturers, septic tank pumping technicians report many pills are found intact in the sewage they pump. Transdermal application bypasses the stomach and liver, resulting in a much greater percentage of the active ingredient passing straight into the bloodstream for ultimate distribution at specific tissues where it’s needed. Magnesium supplementation is actually crucial for everyone today but we have to pay special attention to the method of supplementation because this is critical in terms of effective body utilization. “Magnesium is poorly absorbed orally. That is why I start off with injections. By injecting magnesium I can 100 percent guarantee bringing the levels up. I cannot guarantee this with oral magnesium,” says Dr. Sarah Myhill. Magnesium, applied transdermally, is the ideal magnesium delivery system with medical benefits unequalled in the entire world of medicine. Yet one does not need a doctor to prescribe or administer it. One can relax in a medicinal bath without a doctor’s prescription.
Report on Absorption of Magnesium Sulfate (Epsom Salts) Across the Skin
Dr RH Waring School of Biosciences, University of Birmingham. B15 2TT, U.K. [email protected]
Abstract Magnesium Magnesium levels in blood are very tightly controlled. Of 19 subjects, all except 3 showed a rise in magnesium concentrations in plasma, though this was small in some cases. The values before the first bath were, mean 104.68 ± 20.76 ppm/ml; after the first bath the mean was 114.08 ± 25.83 ppm/ml. Continuation of bathing for 7 days in all except 2 individuals gave a rise to a mean of 140.98 ± 17.00ppm/ml. Prolonged soaking in Epsom salts therefore increases blood magnesium concentrations. Measurement of magnesium levels in urine showed a rise from the control level, mean 94.81 ± 44.26 ppm/ml to 198.93 ± 97.52 ppm/ml after the first bath. Those individuals where the blood magnesium levels were not increased had correspondingly large increases in urinary magnesium showing that the magnesium ions had crossed the skin barrier and had been excreted via the kidney, presumably because the blood levels were already optimal. Generally, urinary magnesium levels 24h after the first bath fell from the initial values found after day 1 (mean 118. 43 ± 51.95) suggesting some retention of magnesium in tissues after bathing as blood levels were still high. Measurement of magnesium levels in urine 24h after the 7th bath gave values almost back to control levels. Sulfate Free inorganic sulfate levels in plasma rose in all subjects after bathing in Epsom salts (mean pre-bath, 3.28 nmol/mg protein ± 1.40, 2h after 1st bath, mean 5.59 nmol/mg protein ± 3.08). In some individuals, the level post-bath reached > 9 nmol/mg protein. The plasma levels after 7 days showed a mean of 3.57 nmol/mg protein ± 1.70, lower than the peak value, suggesting that sulfate stores in the body were being filled. Analysis of the urine samples again showed an increase in sulfate concentrations (pre-bath mean 623.74 ± 352.34 nmols/ml, 2h post bath 1093.30 ± 388.79 nmoles/ml, 24h after 1st bath 899.83 ± 483.16 nmols/ml. Sulfate excretion in urine in some individuals was only slightly higher after 7 days bathing than the pre-bath levels. Conclusion Bathing in Epsom salts is a safe and easy way to increase sulfate and magnesium levels in the body.
Magnesium, Stress and Neuropsychiatric Disorders
Leo Galland Great Smokies Diagnostic Laboratory, Asheville, N.C., USA
Abstract
Magnesium has a profound effect on neural excitability; the most characteristic signs and symptoms of Mg deficiency are produced by neural and neuromuscular hyperexcitability. These create a constellation of clinical findings termed tetany syndrome (TS). TS symptoms include muscle spasms, cramps and hyperarousal, hyperventilation and asthenia. Physical signs (Chvostek's, Trousseau's or von Bonsdorff's) and abnormalities of the electromyogram or electroencephalogram can usually be elicited. Signs and symptoms of TS are frequently encountered in clinical practice, especially among patients with functional or stress-related disorders. The role of Mg deficit in TS is suggested by relatively low levels of serum or erythrocyte Mg and by the clinical response to oral Mg salts, which has been demonstrated in controlled studies. Among the more serious neurologic sequelae of TS are migraine attacks, transient ischemic attacks, sensorineural hearing loss and convulsions. Mg deficiency may predispose to hyperventilation and may sensitize the cerebral vasculature to the effects of hypocarbia. Mg deficiency increases susceptibility to the physiologic damage produced by stress, and Mg administration has a protective effect; studies on noise stress and noise-induced hearing loss are taken as an example. In addition, the adrenergic effects of psychological stress induce a shift of Mg from the intracellular to the extracellular space, increasing urinary excretion and eventually depleting body stores. Drugs used in neurology and psychiatry may affect Mg levels in blood and may diminish signs of tetany, making assessment of Mg status more difficult. Pharmacologic use of Mg can decrease neurologic deficit in experimental head trauma, possibly by blockade of N-methyl-D-aspartate receptors. In conjunction with high doses of pyridoxine, Mg salts benefit 40% of patients with autism, possibly by an effect on doparnine metabolism. http://www.mdheal.org/magnesiu1.htm
Magnesium and Affective Disorders By Murck H.
Abstract
There are several findings on the action of magnesium ions supporting their possible therapeutic potential in affective disorders. Examinations of the sleep-electroencephalogram (EEG) and of endocrine systems point to the involvement of the limbic-hypothalamus-pituitary-adrenocortical axis as magnesium affects all elements of this system. Magnesium has the property to suppress hippocampal kindling, to reduce the release of adrenocorticotrophic hormone (ACTH) and to affect adrenocortical sensitivity to ACTH. The role of magnesium in the central nervous system could be mediated via the N-methyl-D-aspartate-antagonistic, gamma-aminobutyric acidA-agonistic or a angiotensin II-antagonistic property of this ion. A direct impact of magnesium on the function of the transport protein p-glycoprotein at the level of the blood-brain barrier has also been demonstrated, possibly influencing the access of corticosteroids to the brain. Furthermore, magnesium dampens the calciumion-proteinkinase C related neurotransmission and stimulates the Na-K-ATPase. All these systems have been reported to be involved in the pathophysiology of depression. Despite the antagonism of lithium to magnesium in some cell-based experimental systems, similarities exist on the functional level, i.e. with respect to kindling, sleep-EEG and endocrine effects. Controlled clinical trials examining the effect of Mg in affective disorder are warranted.
https://www.ncbi.nlm.nih.gov/pubmed/12509067
Ketamine, Magnesium and Major Depression--From Pharmacology to Pathophysiology and Back
By Murck H.
Abstract The glutamatergic mechanism of antidepressant treatments is now in the center of research to overcome the limitations of monoamine-based approaches. There are several unresolved issues. For the action of the model compound, ketamine, NMDA-receptor block, AMPA-receptor activation and BDNF release appear to be involved in a mechanism, which leads to synaptic sprouting and strengthened synaptic connections. The link to the pathophysiology of depression is not clear. An overlooked connection is the role of magnesium, which acts as physiological NMDA-receptor antagonist: 1. There is overlap between the actions of ketamine with that of high doses of magnesium in animal models, finally leading to synaptic sprouting. 2. Magnesium and ketamine lead to synaptic strengthening, as measured by an increase in slow wave sleep in humans. 3. Pathophysiological mechanisms, which have been identified as risk factors for depression, lead to a reduction of (intracellular) magnesium. These are neuroendocrine changes (increased cortisol and aldosterone) and diabetes mellitus as well as Mg(2+) deficiency. 4. Patients with therapy refractory depression appear to have lower CNS Mg(2+) levels in comparison to health controls. 5. Experimental Mg(2+) depletion leads to depression- and anxiety like behavior in animal models. 6. Ketamine, directly or indirectly via non-NMDA glutamate receptor activation, acts to increase brain Mg(2+) levels. Similar effects have been observed with other classes of antidepressants. 7. Depressed patients with low Mg(2+) levels tend to be therapy refractory. Accordingly, administration of Mg(2+) either alone or in combination with standard antidepressants acts synergistically on depression like behavior in animal models.
CONCLUSION: On the basis of the potential pathophysiological role of Mg(2+)-regulation, it may be possible to predict the action of ketamine and of related compounds based on Mg(2+) levels. Furthermore, screening for compounds to increase neuronal Mg(2+) concentration could be a promising instrument to identify new classes of antidepressants. Overall, any discussion of the glutamatergic system in affective disorders should consider the role of Mg(2+).
https://www.ncbi.nlm.nih.gov/pubmed/23541145
Consequences of Magnesium Deficiency on the Enhancement of Stress Reactions; Preventive and
Therapeutic Implications (A Review)
Mildred S. Seelig, MD, MPH, Master ACN
Department of Nutrition, Schools of Public Health and Medicine, University of North Carolina, Chapel Hill
Abstract Stress intensifies release of catecholamines and corticosteroids, that increase survival of normal animals when their lives are threatened. When magnesium (Mg) deficiency exists, stress paradoxically increases risk of cardiovascular damage including hypertension, cerebrovascular and coronary constriction and occlusion, arrhythmias and sudden cardiac death (SCD). In affluent societies, severe dietary Mg deficiency is uncommon, but dietary imbalances such as high intakes of fat and/or calcium (Ca) can intensify Mg inadequacy, especially under conditions of stress. Adrenergic stimulation of lipolysis can intensify its deficiency by complexing Mg with liberated fatty acids (FA). A low Mg/Ca ratio increases release of catecholamines, which lowers tissue (i.e. myocardial) Mg levels. It also favors excess release or formation of factors (derived both from FA metabolism and the endothelium), that are vasoconstrictive and platelet aggregating; a high Ca/Mg ratio also directly favors blood coagulation, which is also favored by excess fat and its mobilization during adrenergic lipolysis. Auto-oxidation of catecholamines yields free radicals, which explains the enhancement of the protective effect of Mg by anti-oxidant nutrients against cardiac damage caused by beta-catecholamines. Thus, stress, whether physical (i.e. exertion, heat, cold, trauma - accidental or surgical, burns), or emotional (i.e. pain, anxiety, excitement or depression) and dyspnea as in asthma increases need for Mg. Genetic differences in Mg utilization may account for differences in vulnerability to Mg deficiency and differences in body responses to stress.
http://www.mgwater.com/conseq.shtml#ABSTRACT
Magnesium Sulfate is the Ideal Anticonvulsant in Pre-Eclampsia
Abstract The pathogenesis of eclamptic convulsions is unknown. A review of the world literature indicates considerable controversy regarding the ideal anticonvulsant to prevent or control these convulsions. Parenteral magnesium sulfate is the drug of choice to control eclamptic convulsions in North America, but it is rarely used for this purpose overseas. The efficacy and safety of magnesium sulfate in the treatment of preeclampsia-eclampsia have been well documented during the past 60 years. During the same time period, numerous anticonvulsant drugs have been used overseas; however, the ideal drug is yet to be found. Recently phenytoin has been recommended as an alternative for magnesium sulfate; however, comprehensive data regarding its safety and efficacy are lacking. The evidence in the literature indicates that magnesium sulfate is the ideal anticonvulsant in preeclampsia-eclampsia.
https://www.ncbi.nlm.nih.gov/pubmed/2288560
A Comparison of Magnesium Sulfate with Phenytoin for the Prevention of Eclampsia
Lucas, MJ, Leveno KJ, Cunningham FG
Abstract BACKGROUND: Magnesium sulfate is used widely to prevent eclamptic seizures in pregnant women with hypertension, but few studies have compared the efficacy of magnesium sulfate with that of other drugs. Anticonvulsant prophylaxis with phenytoin for eclampsia has been recommended, but there are virtually no data to support its efficacy. Our objective was to compare magnesium sulfate with phenytoin in preventing seizures in hypertensive women during labor. CONCLUSIONS: Magnesium sulfate is superior to phenytoin for the prevention of eclampsia in hypertensive pregnant women. These results validate the long-practiced use of magnesium sulfate in the prevention of eclampsia. https://www.ncbi.nlm.nih.gov/pubmed/7791836
Action of Magnesium Sulfate in the Treatment of Pre-Eclampsia
Sadeh M
Abstract Recent evidence supports the concept that cerebral vasospasm is involved in the pathogenesis of eclampsia. Magnesium, which has a beneficial effect in eclampsia, may act by opposing calcium-dependent arterial constriction, thereby relieving vasospasm. Magnesium may also antagonize the increase in intracellular calcium concentration caused by ischemia and thus prevent cell damage and death. Magnesium might have a role in the treatment of cerebral vasospasm and ischemia, such as occurs in subarachnoid hemorrhage, ischemic stroke, and brain trauma.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1116139/ Rapid Recovery from Major Depression Using Magnesium
Treatment
George A. & Karen L. Eby
Abstract Major depression is a mood disorder characterized by a sense of inadequacy, despondency, decreased activity, pessimism, anhedonia and sadness where these symptoms severely disrupt and adversely affect the person’s life, sometimes to such an extent that suicide is attempted or results. Antidepressant drugs are not always effective and some have been accused of causing an increased number of suicides particularly in young people. Magnesium deficiency is well known to produce neuropathologies. Only 16% of the magnesium found in whole wheat remains in refined flour, and magnesium has been removed from most drinking water supplies, setting a stage for human magnesium deficiency. Magnesium ions regulate calcium ion flow in neuronal calcium channels, helping to regulate neuronal nitric oxide production. In magnesium deficiency, neuronal requirements for magnesium may not be met, causing neuronal damage which could manifest as depression. Magnesium treatment is hypothesized to be effective in treating major depression resulting from intraneuronal magnesium deficits. These magnesium ion neuronal deficits may be induced by stress hormones, excessive dietary calcium as well as dietary deficiencies of magnesium. Case histories are presented showing rapid recovery (less than 7 days) from major depression using 125–300 mg of magnesium (as glycinate and taurinate) with each meal and at bedtime. Magnesium was found usually effective for treatment of depression in general use. Related and accompanying mental illnesses in these case histories including traumatic brain injury, headache, suicidal ideation, anxiety, irritability, insomnia, postpartum depression, cocaine, alcohol and tobacco abuse, hypersensitivity to calcium, short-term memory loss and IQ loss were also benefited. Dietary deficiencies of magnesium, coupled with excess calcium and stress may cause many cases of other related symptoms including agitation, anxiety, irritability, confusion, asthenia, sleeplessness, headache, delirium, hallucinations and hyperexcitability, with each of these having been previously documented. The possibility that magnesium deficiency is the cause of most major depression and related mental health problems including IQ loss and addiction is enormously important to public health and is recommended for immediate further study. Fortifying refined grain and drinking water with biologically available magnesium to pre-twentieth century levels is recommended. http://www.medical-hypotheses.com/article/S0306-9877(06)00103-4/abstract
The Mineral That Could Have Saved 4 Million Women
By Bill Sardi
Abstract Modern medicine has made a remarkable admission. Its failure to utilize a simple, inexpensive intravenous mineral drip might have saved the lives millions of women over the past century. Modern medicine knew about the cure since 1906. [New England Journal Medicine 333: 201-05, 1995]
Around 210 million women become pregnant annually around the world and every minute a woman dies in pregnancy or childbirth, with a quarter of these deaths due to a condition called pre-eclampsia which can lead to the more severe and mortal condition called eclampsia. Women may develop high blood pressure during pregnancy (pre-eclampsia) and during or prior to birth may experience life-threatening seizures (eclampsia). About 5-10 percent of women in their first pregnancy develop pre-eclampsia.
Over the past century, drugs rather than minerals have been employed to treat eclampsia, Diazepam (Valium) in 1968 and then phenytoin (Dilantin) in 1987. During the period 1905 to 1987 an estimated 42 million women may have undergone eclamptic convulsion and possibly 4 million died. The modern therapy for eclampsia now includes calcium-blocking drugs and a host of anti-hypertensive agents. Drugs may reduce the risk of severe high blood pressure, but not the overall rate of hypertension nor the risk of eclampsia. [The Cochrane Library, Issue 2, 2002] Yet the anticonvulsant drugs continue to be employed with little reliable evidence that they work.
Finally, a just-released study of 10,141 women in 33 countries has shown beyond a “reasonable doubt” that intravenous magnesium reduces the risks of eclampsia among women with pre-eclampsia. The relative risk of eclampsia was reduced by 58 percent and the mortality rate nearly cut in half among women receiving magnesium compared to those who receive a saline drip. The authors of the study concluded that “magnesium sulfate is remarkably effective at reducing the risk of eclampsia.” [The Lancet 359: 1877-90, June 1, 2002]
Not The First Time This wasn’t the first study to conclusively show magnesium sulfate is a remedy for eclampsia. In a 1995, a study heralded as the most important obstetric trial of the 20th century, magnesium sulfate was found to be the most effective approach to controlling convulsions during childbirth. [British Medical Journal 311: 702-03, 1995] By 1998 data from numerous studies had been analyzed and it was known that magnesium was superior to any anticonvulsant drugs. [Cochrane Review 2002] This evidence still didn’t convince most obstetrical doctors.
Seven years after the report showing magnesium reduces the risk of mortality from eclampsia, a report endorsed by the World Health Organization (WHO), UNICEF and the WORLD BANK, magnesium sulfate is still not available to millions of women worldwide. British medical researchers are pleading with the World Bank and WHO to fund and disseminate treatment kits. [The Lancet 359: June 1, 2002]
https://www.lewrockwell.com/2002/06/bill-sardi/it-could-have-saved-4-million-women/
Magnesium Intake During Pregnancy Kay B. Franz
Department of Food Science and Nutrition, Brigham Young University, Provo, Utah, USA
Abstract The mean dietary magnesium intake of pregnant women is 35-58% of the recommended dietary allowance of 450 mg. Low-income women consumed 97-100 mg magnesium/1,000 kcal while women with higher incomes averaged 120 mg/1,000 kcal. Diets high in fat and sugar and low in whole grains, vegetables and fruits have a lower magnesium density. Magnesium content of water can also make a significant contribution to magnesium intake. Magnesium from prenatal supplements, if present, is seldom more than 100 mg. Additional supplementation is needed for adequate magnesium during pregnancy. http://www.mgwater.com/preg.shtml
Effects of Magnesium Supplementation on Testosterone Levels of Athletes and Sedentary Subjects at Rest and
After Exhaustion
Cinar V., Polat Y., Baltaci AK, Moqulkoc R. Abstract
This study was performed to assess how 4 weeks of magnesium supplementation and exercise affect the free and total plasma testosterone levels of sportsmen practicing tae kwon do and sedentary controls at rest and after exhaustion. The testosterone levels were determined at four different periods: resting before supplementation, exhaustion before supplementation, resting after supplementation, and exhaustion after supplementation in three study groups, which are as follows: Group 1-sedentary controls supplemented with 10 mg magnesium per kilogram body weight. Group 2-tae kwon do athletes practicing 90-120 min/day supplemented with 10 mg magnesium per kilogram body weight. Group 3-tae kwon do athletes practicing 90-120 min/day receiving no magnesium supplements. The free plasma testosterone levels increased at exhaustion before and after supplementation compared to resting levels. Exercise also increased testosterone levels relative to sedentary subjects. Similar increases were observed for total testosterone. Our results show that supplementation with magnesium increases free and total testosterone values in sedentary and in athletes. The increases are higher in those who exercise than in sedentary individuals.
https://www.ncbi.nlm.nih.gov/pubmed/20352370
Magnesium and Anabolic Hormones in Older Men Maggio M, Ceda GP, Lauretani F, Cattabiani C, Avantaggiato E, Morganti S, Ablondi
F, Bandinelli S, Dominguez LJ, Barbagallo M, Paolisso G, Semba RD, Ferrucci L.
Abstract Optimal nutritional and hormonal statuses are determinants of successful ageing. The age associated decline in anabolic hormones such as testosterone and insulin-like growth factor 1 (IGF-1) is a strong predictor of metabolic syndrome, diabetes and mortality in older men. Studies have shown that magnesium intake affects the secretion of total IGF-1 and increase testosterone bioactivity. This observation suggests that magnesium can be a modulator of the anabolic/catabolic equilibrium disrupted in the elderly people. However, the relationship between magnesium and anabolic hormones in men has not been investigated. We evaluated 399 ≥65-year-old men of CHIANTI in a study population representative of two municipalities of Tuscany (Italy) with complete data on testosterone, total IGF-1, sex hormone binding globulin (SHBG), dehydroepiandrosterone sulphate (DHEAS) and serum magnesium levels. Linear regression models were used to test the relationship between magnesium and testosterone and IGF-1. Mean age of the population was 74.18 ± 6.43 (years ± SD, age range 65.2-92.4). After adjusting for age, magnesium was positively associated with total testosterone (β ± SE, 34.9 ± 10.3; p = 0.001) and with total IGF-1 (β
± SE, 15.9 ± 4.8; p = 0.001). After further adjustment for body mass index (BMI), log (IL-6), log (DHEAS), log (SHBG), log (insulin), total IGF-1, grip strength, Parkinson's disease and chronic heart failure, the relationship between magnesium and total testosterone remained strong and highly significant (β ± SE, 48.72 ± 12.61; p = 0.001). In the multivariate analysis adjusted for age, BMI, log (IL-6), liver function, energy intake, log (insulin), log (DHEAS), selenium, magnesium levels were also still significantly associated with IGF-1 (β ± SE, 16.43 ± 4.90; p = 0.001) and remained significant after adjusting for total testosterone (β ± SE, 14.4 ± 4.9; p = 0.01). In a cohort of older men, magnesium levels are strongly and independently associated with the anabolic hormones testosterone and IGF-1.
https://www.ncbi.nlm.nih.gov/pubmed/21675994 Excessive Magnesium Intake Reduces Testicular Oxidative Stress and Promotes Male Reproductive Function in Rats
Amar K Chandraa*, Pallav Senguptaa, Haimanti Goswamia & Mahitosh Sarkarb
Reproductive Physiology Laboratory, Department of Physiology, University of Calcutta, India
Abstract Magnesium, an important element for health and disease has been identified as a cofactor in various enzymatic reactions including energy metabolism, protein and nucleic acid biosynthesis. Its supplementation has shown to be beneficial in hypertension, treatment of angina; on the contrary its detrimental effect on thyroidal activity has also been recognized. Hypothesis: Available literature on the effect of excess magnesium on male reproductive system is scanty. Therefore to elucidate the effect of excess dietary magnesium on the alteration in male reproductive system as well as the generation of oxidative stress has been undertaken in this investigation. Materials and Methods: Adult male Wister strain rats were fed with MgSO4 at different doses for 13 and 26 days respectively. Effect of magnesium supplementation was estimated by using parameters like relative weights of testicular and accessory sex organs, sperm count, serum testosterone, LH & FSH levels, steroidogenic enzymes activities (testicular and adrenal Δ5 3β-HSD & testicular 17β-HSD) and testicular histoarchitecture. Induction of oxidative stress has been evaluated by testicular lipid peroxidation and antioxidant enzymes profile (SOD and catalase). Results: A significant increase was observed in testicular steroidogenic enzymes activities followed by serum testosterone level and other reproductive parameters (P<0.05), however, excess magnesium was found to cause reduction in oxidative stress in testis of rats as noted by reduced rate of lipid peroxidation. Discussion: Overall finding depicts magnesium supplementation boosts male reproductive activity and reduces oxidative stress. https://www.researchgate.net/publication/216839338
Dr. Mark Sircus, Transdermal Magnesium Therapy, 2007
“Sex in particular has become a major source of anxiety and stress for many of us and this is not all our fault… Magnesium is necessary for normal sexual functioning, yet is glossed over in its importance in nervous and endocrine function necessary for good sexual performance”.
Magnesium levels are very high in the semen – higher than in the blood serum. Infertile men have been found to have half the level of magnesium in their semen as fertile men.
Magnesium affects the production and transmission of all hormones in the body – serotonin, thyroid, estrogen, testosterone, insulin, neurotransmitters, etc.
Erectile dysfunctions in men are closely related to magnesium deficiency. Dr Sircus points out that transdermal supplementation of magnesium leads to a boost of magnesium in the body and increase in DHEA and testosterone, which helps to improve the sexual function and libido, both in men and women.
Transdermal magnesium supplementation normalizes levels of DHEA and boosts levels of testosterone in men and to a smaller extent in women. It balances the levels of estrogen and progesterone in women, thus reducing menopausal symptoms, menstrual problems, PMT, development of pre-eclampsia in pregnant women.
A boost in magnesium levels through transdermal supplementation is fast and free of side-effects which sometimes arise with oral supplementation. Because of the speed with which magnesium levels are replenished through transdermal procedures, the effects of it can be felt quickly on all levels, including reproductive function both in men and women.
Dr Sircus writes, referring to a study in Japan: “In men, decreased levels of magnesium gives rise to vasoconstriction from increased thromboxane level, increased endothelial intracellular calcium, and decreased nitric oxide. This may lead to premature emission and ejaculation processes. Magnesium is also probably involved in semen transport” (Magnesium for Life, 2007, p.244).
Interestingly, the topical application of magnesium to reproductive organs on a regular basis, especially just before having sex. Such applications would relax the tissues and quickly increase blood circulation in the area, both in men and women. It would also promote vaginal lubrication and relaxation of the muscles in the vagina, which would help eliminate the sensation of pain and discomfort during sex. In men it would lead to a relaxation of the blood vessels supplying the penis, an increase in the blood flow and sensation in the area, and a stronger, longer lasting erection.
Transdermal applications increase absorption of magnesium into the body, dilate blood vessels, relax muscles and body tissues, increase peripheral circulation, improve tissue sensitivity and fluid secretions.
http://www.magnesiumoil.org.uk/magnesium-sexual-health/
PRODUCT RESEARCH/INGREDIANTS
PRODUCT INGREDIANT FUNCTIONAL BENEFITS RESEARCH
DISTRESSology Arnica Montana • Relieves pain
• Reduces inflammation • Moisturizes skin
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Vanilla Essential Oil • Antidepressant, sedative, tranquilizing and relaxing substance
• Prevents free radical damage • calming effect on the brain
and the nerves
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Peppermint Essential Oil Peppermint is able to provide relief from stress, depression and mental exhaustion due to its refreshing nature. It is also effective against anxiety and restlessness. Furthermore, it stimulates mental activity, clears the mind, and increases focus on cognitive tasks.
https://www.organicfacts.net/health-benefits/essential-oils/health-benefits-of-peppermint-oil.html
Tangerine/Orange/Ginger Essential Oils
• Antiseptic • Purifies blood and removes
toxins • Quick and effective relief
from ingestion of toxic substances
• Expectorant, analgesic, anti-inflammatory
• Improves digestion • Stress reliever
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Gardenia Essential Oil • Boosts strength and https://www.organicfacts.net/
functionality of the respiratory, digestive, circulatory, nervous, and excretory systems.
• Adds tone to muscles and skin and can improve your overall appearance
• Powerful effects to uplift spirits and mental functioning, which makes it useful in the treatment of depression, chronic anxiety, and anger issues.
health-benefits/essential-oils/health-benefits-of-geranium-essential-oil.html
Lobelia Inflata • Relaxant in the presence of pain
• Helps skin irritation • Treats sprains and bruising
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Zoelite/Boron • Enhances brain function • Increases concentration
https://www.organicfacts.net/health-benefits/minerals/boron.html
Wintergreen Essential Oil • Pain reliever • Increases circulation • Antispasmodic
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Peppermint Essential oil • Alleviates the pain of a headache
• Provide relief from stress, depression and mental exhaustion due to its refreshing nature
• Effective against anxiety and restlessness
• Stimulates mental activity, clears the mind, and increases focus on cognitive tasks
https://www.organicfacts.net/health-benefits/essential-oils/health-benefits-of-peppermint-oil.html
Mama Maggy’s Arnica Montana • Helps reduce post-partum
bleeding • Relieves pain • Reduces inflammation • Heals broken blood vessels • Moisturizes skin
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Witch Hazel • Helps with constipation • Moisturizer for stretching
skin • Remedy for bloating and gas • Hemorrhoid relief • Helps with yeast infections
https://wellnessmama.com/60603/uses-for-witch-hazel/
Zoelite/Boron • Supports bone development • Improves estrogen
production • Essential for reproduction
and development of the fetus
• Prevents blood clots
https://www.organicfacts.net/health-benefits/minerals/boron.html
Eucalyptus Essential Oil • Antiseptic • Heals wounds, cuts,
abrasions • Removes exhaustion and
mental sluggishness • Treats stress • Immune stimulant • Antioxidant
Medline https://www.ncbi.nlm.nih.gov/pubmed/20359267
Baby Soft Essential Oil: Combination of the following essential oils:
Rosewood • Calming oil • Analgesic • Antidepressant • Antiseptic • Aphrodisiac • Antibacterial
https://www.organicfacts.net/health-benefits/essential-oils/health-benefits-of-rosewood-essential-oil.html
Palmarosa • Antiviral • Antibacterial • Antiseptic • Promotes the growth of cells • Helps body retain moisture • Relaxes the muscles and
nerves • Fights depression,
fatigue, anxiety, anger and nervousness
• Has an uplifting effect on the mind
https://www.organicfacts.net/health-benefits/essential-oils/health-benefits-of-palma-rosa-essential-oil.html
Elmi Tonic helps in the growth and proper functioning of the body by toning up all the organic systems functioning in the body, such as the respiratory, digestive, cardiovascular, circulatory, neural, excretory, nervous, and endocrinal systems. It also boosts the immune system of the body. Joint pain
https://www.organicfacts.net/health-benefits/essential-oils/health-benefits-of-elemi-essential-oil.html
Ylang Ylang • Antidepressant • Lowers blood pressure • Relief from stress and
anxiety • Helps with insomnia
https://www.organicfacts.net/health-benefits/essential-oils/health-benefits-of-ylang-ylang-essential-oil.html
Geranium • Reduces inflammation • Lower stress • Strengthens immune system
https://www.organicfacts.net/health-benefits/herbs-and-spices/geranium.html
Patchouli Antidepressant, antiphlogistic, antiseptic, aphrodisiac, astringent, cicatrisant, cytophylactic, deodorant, diuretic, febrifuge, fungicide, insecticide, sedative
https://www.organicfacts.net/health-benefits/essential-oils/health-benefits-of-patchouli-essential-oil.html
Rose • Antidepressant, antiphlogistic, antiseptic, antispasmodic, antiviral, aphrodisiac, astringent, bactericidal, cholagogue, cicatrisant, depurative, emenagogue, haemostatic, hepatic, laxative, nervine, stomachic and uterine
• Uterine discharge, tumors, bleeding, and irregular menses. It purifies the uterus as well, and keeps it functioning properly even in advanced age, thereby delaying menopause.
• By regulating menstruation, it is possible to eliminate the associated symptoms and problems of menstruation, including mood swings, hormonal imbalance, overeating, bloating, cramping, and excessive bleeding
https://www.organicfacts.net/health-benefits/essential-oils/health-benefits-of-rose-essential-oil.html
Boom Boom Butter
Coconut Essential Oil • Alleviates dry skin • Skin conditioner • Removes stress • Antifungal • Antibacterial • Antiviral • Effective way to deal with
STDs • Relieves inflammation from
Candida • Speeds up healing process
Coconut Research Center www.coconutresearchcenter.org
from damaged tissues • Carrier oil helps absorb
other oils Boswelia Seratta • Anti-inflammatory
• Skin health • Mental peace • Uterine health • Pain reliever
https://www.organicfacts.net/health-benefits/essential-oils/health-benefits-of-frankincense-essential-oil.html
Shea Butter • Moisturizer • Anti-inflammatory • Skin smoother
https://wellnessmama.com/27324/shea-butter-benefits/
Arnica Montana • Relieves pain • Reduces inflammation • Moisturizes skin
https://www.organicfacts.net/health-benefits/herbs-and-spices/arnica-montana.html
Lobelia Inflata • Relaxant in the presence of pain
• Helps skin irritation
http://www.anniesremedy.com/herb_detail246.php?gc=246&gclid=CKnhhoKA9dICFYiEswodSSADSw
Zoelite/Boron • Enhances testosterone levels • Brings back sex drive in
post-menopausal women
https://www.organicfacts.net/health-benefits/minerals/boron.html
