9. NATURAL PRODUCT & DRUG DELIVERY

The workgroups of this theme area under UPE II are spread over four units. These are

1. Department of Pharmaceutical Technology & School of Natural Product Studies

2. Department of Chemical Engineering

3. Department of Chemistry, Organic Chemistry Section

4. Department of Food Technology & Biochemical Engineering

9.1. Department of Pharmaceutical Technology & School of Natural Product Studies

9.1.1. Contributing Faculty Members

Dr. Kunal Roy, Department of Pharmaceutical Technology, Age: 43, Journal Publications – 200, Conference Publications – 40, Patents – 0, Policy Documents – 0, H Index – 27, Cumulative Impact Factor – Not known, Total Citations – 3364, Awarded and ongoing doctoral thesis guidance – 11, Awarded and ongoing Master’s thesis guidance – 08

Dr. Amalesh Samanta Department of Pharmaceutical Technology, Age: 52, Journal Publications – 50, Conference Publications – Nil, Patents – Applied(1), Policy Documents – 0, H Index – 7, Cumulative Impact Factor –35.17, Total Citations – 167, Awarded and ongoing doctoral thesis guidance – 11, Awarded and ongoing Masters thesis guidance – 08

Prof.(Dr.) Tapan Kumar Maity, Department of Pharmaceutical Technology, Jadavpur University Age- 48 years, Journal Publications- 61, Conference Publications-9(International)& 5(National)Patents 0, Policy Documents-0 ,H-Index-not known, Cumulative Impact Factor- Notknown Total Citations - not known

Dr. Pulok K Mukherjee, Director, School of Natural Product Studies,Dept. of

Pharmaceutical Technology, Jadavpur University, Age – 46 yrs, Journal Publications – 163, Book Chapters Edited/authored – 19, Conference Publications – 8, Cumulative Impact Factor – 179.76, H-index – 28, total citation 3950 times in 2219 reputed journals and documents (Scopus); Google web search - H-index – 37, total citation over 5470 times, Awarded and ongoing doctoral thesis guidance – 20, Awarded and ongoing Master’s thesis guidance – 24.

Prof. (Dr.) Biswanath Sa,Dept. of Pharmaceutical Technology, Jadavpur University, Age – 62 yrs, Journal Publications – 90, Patents-2,Cumulative Impact Factor – not known, H-index – 16, total citations-652; Awarded and ongoing doctoral thesis guidance – 14, Awarded and ongoing Master’s thesis guidance – 48.

Dr.Tuhinadri Sen , Dept. of Pharmaceutical Technology, Age –49yrs, Book

contribution - 8, Journal Publications –42, H Index – 13, Total Citations – 477, Awarded and ongoing doctoral thesis guidance – 16 number, Awarded and ongoing Master’s thesis guidance – 20.

Dr. Sanmoy karmakar , Dept. of Pharmaceutical Technology, Jadavpur University, Age – yrs, Journal Publications – , Patents-,Cumulative Impact Factor – not known, H-index – , total citations-; Awarded and ongoing doctoral thesis guidance –08 , Awarded and ongoing Master’s thesis guidance – 11 .

9.1.2. Special Achievements

Dr. Kunal Roy- Fellow, Manchester Institute of Biotechnology, Manchester, United Kingdom Associate Editor, Molecular Diversity (Springer) of Editorial Advisory Board Associate Editor, European Journal of Medicinal Chemistry (Elsevier)

Dr.Tuhinadri Sen

1. Visiting Scientist, Institut Genomique Fonctionnelle, France (INSERM Poste Vert Fellowship)

2. KU Leuven, Belgium, (ERASMUS MUNDUS visiting fellow),

3. UCD, Dublin (ERASMUS MUNDUS Visiting Fellow)

4. Visiting Scinetist - UFMG, Belo Horizonte, Brasil and IKS (MRC, South Africa), Cape Town, South Africa

5. Member Editorial Board, Evidence Based Complimentary and Alternative Medicine (eCAM), New York, USA

6. Member Editorial Advisory Board, OA Evidence Based Complimentary Medicine, OA Publishing, London, UK,

7. Member Editorial Advisory Board, Current Trends in Pharmaceutical Research, Assam, India

8. Member of the Editroial Advisory Board, International Journal of Pharma Research, Tamil Nadu, India.

9. Member, Editorial Board, Current Traditional Medicine, Bentham Science

Dr. Sanmay Karmakar BOYSCAST Fellowship from DST, Ministry of Science & Tech., Govt. of INDIA.

Dr Pulok K Mukherjee

Fellow of the Royal Society of Chemistry [FRSC], Royal Society of Chemistry,

Thomas Graham House, Science Park, Milton Road, Cambridge, U.K, 2007. Member of the Program Advisory Committee (PAC), DST- on Plant Sciences for the

Science & Engineering Research Board (SERB), Dept of Science & Technology, Govt. of India, New Delhi, 2012.

Associate Editor, J. Ethnopharmacology, International Journal on Botanical Research, published by Elsevier Science, the Netherlands 2003 onwards.

Advisor, American Herbal Pharmacopoeia; 3051 Brown's Lane; Soquel, CA 95073 USA, 2010.

Chairman, Natural Health Product SIAC Special Interest Area Community [SIAC], Drug Information Association, Philadelphia, USA, 2009 worked for the development of international coordination for promotion and development of natural products as therapeutically potent compounds.

Council member of the Society for TCM Pharmaceutical Analysis under the world Federation of Chinese Medicine Societies (WFCMS), Shanghai, China, 2010.

Member of panel of expert of the R&D Project evaluation Subcommittee on Chemical Sciences, West Bengal State Council of Science & Technology, Kolkata, 2012.

Chairman of Consortium Advisory Committees [CAC], ICAR- on the subproject Utilization of Weed Flora of Medicinal Value in Some Important Cropping Systems of Andhra Pradesh; National Agricultural Innovation Project, Indian Council of Agricultural Research, Govt. of India, New Delhi, 2011.

Guest editor of Indian Journal of Traditional Knowledge, special issue on “Traditional knowledge of the Northeast India”, January, 2009 published from, National Institute of Science Communication and Information Resources [NISCAIR], CSIR, New Delhi.

Member of Management Advisory Committee [MAC] of National Centre for Natural Resources [NCNR], Department of Science & Technology, New Delhi, 2012.

Expert in Indian Pharmacopoeia Commission [IPC], Ministry of Health & Family Welfare, Govt. of India, Ghaziabad, 2012.

Guest editor of Drug Information Journal, special issue on “Natural Health Products”, September, 2010 published from, Drug Information Association [DIA], Philadelphia, USA.

Chairman syllabus Review Committee for Bachelor and Master Course in Pharmacy for the Sikkim University, a central university established by an act of Parliament of India in 2007; GITAM University, Vishakhapatnam etc.

NISCAIR Panel Expert for the dissemination of information under the journal published by National Institute of Science Communication & information Resources, CSIR, New Delhi.

Zonal coordinator [East Zone] - for Graduate Aptitude Test in Pharmacy: GPAT -2011 examination.

Task Force member of DBT- worked as task force member of Department of Biotechnology Govt. of India for the 10th Five year plan in Biotechnology based Programme for Women and Rural Development, 2002-2007.

Member of the country advisers, Development Partnerships in Higher Education (DelPHE), supported by Department for International Development (DFID), UK, 2010.

President, Association of Pharmaceutical Teachers of India [APTI], Bengal Branch, HQ at Al-Ameen College of Pharmacy, Hosur Road, Bangalore 2009 onwards.

Member of the Editorial Board of Journal of Health Research, an International journal published by Chulalongkorn University, Bangkok, Thailand.

Member of the various prestigious journals

Pharmacognosy Magazine an Indian journal published by Medknow Publications

And Media Pvt. Ltd, Mumbai, India. Scientific Advisory Committee, National Research Institute of Ayurveda for Drug

Development (NRIADD), functioning under Central Council for Research in Ayurveda & Siddha (CCRAS), Kolkata region.

Scientific Advisory Board, Foundation for Enviromental and Economic Developmental Service (FEEDS), Senapati, Manipur, Inida,

Associate Editor, International Journal of Chinese Herbal Medicine (CHM), an International Journal published by Institute of Medicinal Plant Development (IMPLAD), Chinese Academy of Medical Sciences (CAMS) , Beijing, P.R. China

J. Complementary and Integrative Medicine, an International journal published by The Berkeley Electronic Press.

J. Oriental Pharmacy and Experimental Medicine [OPEM], an International journal published by Springer, Institute of Oriental Medicine, South Korea.

J. Natural Remedies [JNR], an Indian journal published by Natural Remedies, Bangalore.

J. Pharmaceutical Research, an Indian journal published by Krupanidhi College of Pharmacy, Bangalore.

J. Pharmaceutical Education, an Indian journal published by Association of Pharmaceutical Teachers of India [APTI].

Indian Journal of Traditional Knowledge [IJTK], a journal published by National Institute of Science Communication & information Resources, CSIR, New Delhi.

Medicinal and Aromatic Plant Abstracts [MAPA], a journal published by National Institute of Science Communication & information Resources, CSIR, New Delhi.

Journal of Health Research, an international journal in the field of health bio sciences, published from Chulalongkorn University, Bangkok, Thailand.

American Journal of Plant Sciences (AJPS), Scientific Research Publishing, USA. Visiting Scientist of various prestigious institutions. School of Pharmacy, London at the Centre for Pharmacognosy and Phytotherapy,

School of Pharmacy, University of London. King’s College London at the Pharmaceutical Science Research division of King’s

College London. Tokushima University at the Institute of Health Bio Sciences, Faculty of

Pharmaceutical Sciences, Tokushima University, Japan. Leiden University at the Leiden Amsterdam Center for Drug Research, Gorlaeus

Laboratories, Dept. of Pharmacognosy. CDS Safety Inc., New Jersey, USA with Dr. P K Paul in the field of Drug safety. World Health Organization [WHO] for the formulation of guidelines on various

aspects of botanicals like GMP, GSP, Regulation, Quality control and allied guidelines.

Prof. (Dr.) Biswanath Sa

Member of Executive Editor- Drug Invention Today Editorial Board Member - Journal of PharmaSciTech (India).

9.1.3 Relevant Projects in Last 10 years including the Ongoing Projects

Dr.Kunal Roy

Project Title

Sponsoring

Agency

Members

Status

Development of AChE-inhibitor for Alzheimer s Disease- Screening Designing Synthesis and Biological validation using Chemical Library & North-East Indian Plants

DBT (Twinning Programme)

Principle Investigator

Ongoing

In silico modeling of ecotoxicological hazards of

CSIR Principle Investigator

Ongoing

chemicals using advanced chemometric tools Exploring Quantitative Structure-Activity Relationships (QSARs) of Selected Classes of Antimalarial Compounds for Development of Predictive Models

UGC Principle Investigator

Ongoing

Predictive In Silico Modeling of Different Classes of Antioxidants of Biological and Medicinal Significance Using Cheminformatics Tools

ICMR Principle Investigator

Ongoing

In silico ADME/Tox prediction using chemometric tools

UGC Principle Investigator

Complete

Dr. Amalesh Samanta

Dr.Tapan Kumar Maity

Project Title Sponsoring Agency

Members Status

Synthesis, characterization and biological evaluation of furfuryl pyrimidine derivatives.

University Grants Commission

(PI) Ongoing

Design, Synthesis, and Pharmacological Screening of Hybrid Urea/Thiourea Derivatives as Potential Antihyperglycemics.

Council of Scientific and Industrial Research

Prof.(Dr.) Tapan Kumar Maity (PI)

Ongoing

Synthesis, Anti cancer activity, and sustained release dosage form design of 1, 3, 4 – oxadiazole derivatives.

UGC sponsored Major Research Project.

Prof.(Dr.) Tapan Kumar Maity (PI)

Ongoing

Project Title Sponsoring Agency

Members Status

Experimental studies on the efficacies of natural materials as binder, emulgent, prebiotics and antimicrobials obtained from a

single plant Odina wodier (Family: Anacardiaceae).

(Ongoing)

University Grants

Commission

(PI)

3 years

Synthesis, Characterization and biological evaluation of some novel phthalimide derivatives.

UGC sponsored Major Research Project.

PI Ongoing

Synthesis, Biological Activity and Dosage Form Design of Some Oxadiazole Derivatives

All India Council forTechnicalEducation

PI Ongoing

Dr.Pulok K Mukherjee

Project Title Sponsoring Agency

Members Status

Novel Drug Discovery And Development Approaches For The Pharmacological Immune Enhancers In Immune Compromised Individuals

India-Brazil-South Africa (IBSA) Trilateral Cooperation Program

PI

Ongoing

Synergistic interaction of anti-bacterial natural products from medicinal plants of North East India: An effort in developing multi drug resistance natural antibiotic lead

Department of Biotechnology (DBT), NER Division New Delhi

PI

Ongoing

Evaluation of safety profile of some Anti-diabetic plants used in Indian System of Medicine

National Medicinal Plants Board (NMPB), New Delhi

PI

Ongoing

Anti aging&Anti wrinkle Formulation with Matrix Metalloproteinase Inhibitory Activity From Natural resources

DST- DPRP, Govt. of India, New Delhi

PI

Completed

Search for Acetyl cholinesterase inhibitors from Indian medicinal plants

DST- SERC, Govt. of India, New Delhi

PI

Completed

Safety evaluation of herbal medicine AICTE –MODROBS, Govt. of India, New Delhi

PI

Completed

Marker analysis for standardization of some Indian medicinal plants - Tool for Standardization of Botanicals

AICTE – RPS, Govt. of India, New Delhi

PI

Completed

Angiotensin converting enzyme (ACE) inhibitors from Indian medicinal plants

CSIR, Extra Mural Research Division, Government of India, New Delhi

PI

Completed

Evaluation of safety profile of herbs used in Ayurveda with CYP- 450 enzymes inhibition method

CCRAS, Govt. of India, New Delhi

PI

Completed

Acetyl cholinesterase [AChE] inhibitors from Indian spices

UGC, Govt. of India, New Delhi

PI

Completed

Dr.Tuhinadri Sen

Title of the Project Sponsoring

Agency Members Status

Pharmacological screening of some traditional medicinal plants from the Sundarban regions

J.U. Minor research grant

PI

Completed

Pharmacological Investigation – Research of Bioactive compounds from marine mollusks.

CSIR PI

Completed

Pharmacological evaluation of the Medicinal Property of the Indian Black Tea.

NTRF PI

Completed

Pharmacological studies on Medicinal Plants from Sunderban mangroves – Screening of Plants for Cyclooxygenase – Lipooxygenase inhibition and free radical scavenging activity for potential therapeutic application in chronic inflammatory disorders.

UGC PI

Completed

Development of antibiotic lead compounds from marine Actinobacteria as potential new generation antibiotics

CSIR PI

Completed

Bioactivity guided purification of a biologically active esterase (acetylcholine esterase like) from the marine mollusk Telescopium telescopium

DRDO PI

Completed

Novel Drug Discovery and Development Approaches for the Pharmacological Immune Compromised Individuals

IBSA (DST India International cooperation)

PI

Ongoing

Dr. Sanmoy Karmakar

Project Title Sponsoring

Agency Members Status

Modernisation of Pharmacy Lab A.I.C.T.E. Govt. of India

PI

Completed

Toxicokinetics study of herbal drug AICTE, RPS, Govt. of India

PI

Completed

“Hypokalemia – A Potent Risk for Drug Induced Long QT – Symptoms”

DST-SERB , Govt of INDIA

PI

On going

Marker analysis for some Indian medicinal plants

AICTE,RPS , Govt. of INDIA

Co-PI

Completed

Evaluation of safety profile of some anti-diabetic plants in Indian System of medicine

National Medicinal Plants Board(AYUSH) Govt of India

Co-PI

Completed

Synergistic Interaction of Anti-bacterial Natural Products from Medicinal Plants of North east India: An Effort in Developing Multi-drug Resistance Natural Antibiotic Leads

Dept. of BioTechnology, Ministry of Sc & Tech. Govt. of INDIA

Co-PI

Ongoing

Strengthening of Existing Facilities with a Special Emphasis to Bioequivalence study of drugs and metabolites in plasma by LC-MS/

Dept. of Science & Technology, Ministry of Science & Technology , (DPRP)

Co-PI

Completed.

9.1.4 Relevant Publications in Last 5years

Dr. Kunal Roy SL NO

Papers

1. Das RN, Roy K, Predictive in silico Modeling of Ionic Liquids toward Inhibition of the Acetyl Cholinesterase Enzyme of Electrophorus electricus: A Predictive Toxicology Approach. Ind Engg Chem Res, 53, 2014, 1020-1032, http://dx.doi.org/10.1021/ie403636q

2. Ambure P, Roy K, Exploring structural requirements of leads for improving activity and selectivity against CDK5/p25 in Alzheimer’s disease: An in silico approach. RSC Advances, 4, 2014, 6702-6709, http://dx.doi.org/10.1039/C3RA46861E

3. Kar S, Gajewicz A, Puzyn T, Roy K, Nano-Quantitative Structure-Activity

Relationship Modeling Using Easily Computable and Interpretable Descriptors for Uptake of Magnetofluorescent Engineered Nanoparticles in Pancreatic Cancer Cells. Toxicol in vitro, 2014, http://dx.doi.org/10.1016/j.tiv.2013.12.018

4. Pramanik S, Roy K, Predictive modeling of chemical toxicity towards Pseudokirchneriella subcapitata using regression and classification based approaches. Ecotox Environ Saf, 101, 2014, 184-190, http://dx.doi.org/10.1016/j.ecoenv.2013.12.030

5. Pal P, Mitra I, Roy K, QSPR modeling of odor threshold of aliphatic alcohols using extended topochemical atom (ETA) indices. Croat Chem Acta, 2013 (Accepted).

6. Aher RB, Roy K, Classification SAR modeling of diverse quinolone compounds for antimalarial potency against Plasmodium falciparum. Comb Chem High Throughput Screen, 2013 (In press), http://www.ncbi.nlm.nih.gov/pubmed/24372050

7. Ambure P, Kar S, Roy K, Pharmacophore Mapping-Based Virtual Screening Followed by Molecular Docking Studies in Search of Potential Acetylcholinesterase Inhibitors as Anti-Alzheimer's Agents. Biosystems, 116, 2014, 10-20, http://dx.doi.org/10.1016/j.biosystems.2013.12.002

8. Kar S, Roy K, Predictive Chemometric Modeling and Three-Dimensional Toxicophore Mapping of Diverse Organic Chemicals Causing Bioluminescent Repression of the Bacterium Genus Pseudomonas. Ind Engg Chem Res, 52, 2013, 17648−17657 http://dx.doi.org/10.1021/ie402803h

9. Pal P, Mitra I, Roy K, QSPR approach to determine the essential molecular functionalities of potent odorants. Flavour Frag J, 2013, http://dx.doi.org/10.1002/ffj.3191

10. Pramanik S, Roy K, Exploring QSTR modeling and toxicophore mapping for identification of important molecular features contributing to the chemical toxicity in Escherichia coli. Toxicol in vitro, 28, 2013, 265-272, http://dx.doi.org/10.1016/j.tiv.2013.11.002

11. Das RN, Roy K, Predictive modeling studies for the ecotoxicity of ionic liquids towards the green algae Scenedesmus vacuolatus. Chemosphere, 2013, http://dx.doi.org/10.1016/j.chemosphere.2013.11.002

12. Pramanik S, Roy K, Modeling bioconcentration factor (BCF) using mechanistically interpretable descriptors computed from open source tool “PaDEL-Descriptor”. Environ Sci Pollut Res, 2013, http://dx.doi.org/10.1007/s11356-013-2247-z

13. Mridha P, Pal P, Roy K, Chemometric modeling of triphenylmethyl (TPM) derivatives as potent anticancer agents. Mol Simul 2014, http://dx.doi.org/10.1080/08927022.2013.854897.

14. Ray S, Roy K, Modeling adsorption of organic compounds on activated carbon using ETA indices. Chem Engg Sci 104, 2013, 427-438, http://dx.doi.org/10.1016/j.ces.2013.09.018

15. Ojha PK, Roy K, First report on exploring structural requirements of alpha and beta thymidine analogs for PfTMPK inhibitory activity using in silico studies. Biosystems 113, 2013, 177-195, http://dx.doi.org/10.1016/j.biosystems.2013.07.005

16. Ojha PK, Roy K, Exploration of important sites of antimalarial endochins for optimum structural modification using group-based QSAR (G-QSAR) modeling. Curr Comput Aid Drug Des 9, 2013, 336-349, http://www.ncbi.nlm.nih.gov/pubmed/24010932

17. Ojha PK, Roy K, Exploring Structural Requirements for a Class of Nucleoside

Inhibitors (PfdUTPase) as Antimalarials: First Report on QSAR, Pharmacophore Mapping and Multiple Docking Studies. Comb Chem High Throughput Screen, 16, 2013, 739-757, http://www.ncbi.nlm.nih.gov/pubmed/23701009

18. Nandy A, Kar S, Roy K, Development and validation of regression based QSAR models for quantification of contributions of molecular fragments to skin sensitization potency of diverse organic chemicals. SAR QSAR Environ Res 2013 (Accepted).

19. Nandy A, Kar S, Roy K, Development of classification and regression based QSAR models and in silico screening of skin sensitization potential of diverse organic chemicals. Mol Simul 2013, http://dx.doi.org/10.1080/08927022.2013.801076

20. Kar S, Roy K, Prediction of milk/plasma concentration ratios of drugs and environmental pollutants using in silico tools: Classification and regression based QSARs and pharmacophore mapping. Mol Inform 32, 2013, 693-705, http://dx.doi.org/10.1002/minf.201300018

21. Pramanik S, Roy K, Environmental toxicological fate prediction of diverse organic chemicals based on steady-state compartmental chemical mass ratio using quantitative structure-fate relationship (QSFR) models. Chemosphere 92, 2013, 600-607, http://10.1016/j.chemosphere.2013.03.065

22. Das RN, Roy K, QSTR with extended topochemical atom (ETA) indices. 16. Development of predictive classification and regression models for toxicity of ionic liquids towards Daphnia magna. J Hazard Mater 254-255, 2013, 166-178, http://dx.doi.org/10.1016/j.jhazmat.2013.03.023

23. Mitra I, Saha A, Roy K, Quantification of contributions of different molecular fragments for antioxidant activity of coumarin derivatives based on QSAR analyses. Canadian J Chem 91, 2013, 428-441, http://dx.doi.org/10.1139/cjc-2012-0527

24. Kar S, Roy K, How far can virtual screening take us in drug discovery? Expert Opin Drug Discov, 8, 2013, 245-261, http://dx.doi.org/10.1517/17460441.2013.761204

25. Roy K, Chakraborty P, Mitra I, Ojha PK, Kar S, Das RN, Some case studies on application of “rm2” metrics for judging quality of QSAR predictions: Emphasis on scaling of response data. J Comput Chem 34, 2013, 1071-1082, http://dx.doi.org/10.1002/jcc.23231 .

Dr. Amalesh Samanta

SL NO

Paper Details

1 D. Ojha, H. Mukherjee, S. Ghosh, P. Bag, S. Mondal, N.S. Chandra, K.C. Mondal, A. Samanta, S. Chakrabarti1 and D. Chattopadhyay. 2013; Evaluation of anti-infective potential of a tribal folklore Odina wodier Roxb against some selected microbes and herpes simplex virus associated with skin infection. Journal of Applied Microbiology. 115(6): 1317-1328.

2 S.M.A. Alli, S.M.A. Ali, A. Samanta. 2011; Development and evaluation of intestinal targeted mucoadhesive microspheres of Bacillus coagulans. Drug Development and Industrial Pharmacy. 37(11): 1329-1338.

3 S.C. Dinda, B. Mukherjee, A. Samanta. 2011; Gum odina: a novel matrix forming material for sustained drug delivery. Oriental Pharmacy and Experimental Medicine. 11: 131-136.

4 A. Samanta, D. Ojha, B. Mukherjee. 2010; Stability analysis of primary emulsion using a new emulsifying agent gum odina. Natural Science. 2(5): 494- 505.

5 B. Mukherjee, A. Samanta, S.C. Dinda. 2006; Gum Odina-A New Tablet Binder. Trends in Applied Sciences Research. 1(4): 309-316.

Dr. Tapan Kumar Maity

SL NO

Paper Details

1. Evaluation of Analgesic and Anti-Inflammatory Activity of Chloroform and Methanol Extracts of Centella asiatica Linn”. Sudipta Saha, Tanmoy Guria, Tanushree Singha, and Tapan Kumar Maity, ISRN Pharmacology, Volume 2013, Article ID 789613, http://dx.doi.org/10.1155/2013/789613.

2. “Synthesis and Evaluation of Antiproliferative activity of 1, 2, 4-Triazole Derivatives against EAC Bearing Mice Model”. Tanushree Singha, Jagadish Singh, Arup Naskar, Tirtha Ghosh, Arijit Mondal, Mrityunjoy Kundu, Ranjit K. Harwansh and Tapan Kumar Maity. Indian Journal of Pharmaceutical Education and Research. 46(4): (2012) Impact factor

3. “Synthesis, Characterizationand Antiproliferative Activity of Some Novel N-[2-(substitutedphenyl)-5-methyl-4-oxo-1,3-thiazolidin-3-yl]benzamides”. G. Nagalakshmi, T.K. Maity and B.C. Maiti. Scholars Research Library, Der Pharmacia Lettre. 3(1):476-489, (2011).

4. “Hypoglycemic effect of Melothria heterophylla in streptozotocin-induced diabetic rats”. Arijit Mondal, Tapan Kumar Maity, Dilipkumar Pal. Pharmaceutical Biology. 50(9): 1151-1156, (2012). Impact factor.

5. “Synthesis, Characterization and Antiproliferative Activityof Some Novel 2-(substitutedphenyl)-5-methyl-3-(pyridine-4-yl)-1, 3-thiazolidin-4-ones”. G. Nagalakshmi, T.K. Maity and B.C. Maiti. International Journal of Pharm Tech Research. 3(2):707-718, (2011).

6. “Anti-inflammatory effect of O-methylated flavonol 2-(3, 4-Dihydroxy-phenyl)-3,5-dihydroxy-7-methoxy-chromen-4-one obtained from Cassia sophera Linn in rats”. Arijit Mondal, D. Rajalingam and Tapan Kumar Maity. Journal of Ethnopharmacology.http://dx.doi.org/10.1016/j.jep.2013.01.021.

7. “Synthesis, Characterization and Antiproliferative Activity of Some Novel 2-(Substitutedphenyl)-5-Methyl-3-(Phenylamino)-1,3-Thiazolidin-4-ones”.G. Nagalakshmi, T.K. Maity and B.C. Maiti. Pharmacologyonline. 1:1228-1246, (2011).

8. “Evaluation of hepatoprotective effect of leaves of Cassia sophera Linn”. Arijit Mondal, Sanjay Kumar Karan, Tanushree Singha, D. Rajalingam, Tapan Kumar Maity. Evidence-Based Complementary and Alternative Medicine. Article ID 436139, doi. 10.1155/2012/436139, (2012), Impact factor.

9. “Oxygen-Dependent-Regulation of Ehrlich’s Ascites Carcinoma Cell Respiration by

Gallic acid and Rutin isolated from Melothria heterophylla (Lour.) Cogn”. Arijit Mondal, Tapan Kumar Maity, Dilipkumar Pal. Asian Journal Chemistry. 24(6): 2648-2650, (2012). Impact factor.

10. “Isolation and In vivo hepatoprotective activity of Melothria heterophylla (Lour.) Cogn. against chemically induced liver injuries in rats”. Arijit Mondal, Tapan Kumar Maity, Dilipkumar Pal, Santanu Sannigrahi and Jagadish Singh. Asian Pacific Journal of Topical Medicine. 4 (8): 619-623, (2011).

11. “Antihyperglycemics Activity of Bacosine, a Triterpene from Bacopa monnieri, in Alloxan-Induced Diabetic Rats.” Tirtha Ghosh, Tapan Kumar Maity, Jagadish Singh. Planta Medica 77:804–808, (2011).

12. “Synthesis and Anticancer Activity of 3, 5-Diaryl 1,2,4-Oxadiazole Derivatives”. Mrityunjoy Kundu, Brijesh singh, Tritha Ghosh, Jagadish singh and Tapan Kumar Maity. Indian Journal of Pharmaceutical Education and Research. 45(3): 267-271, (2011).

13. “Synthesis and Anti-Proliferative Activity of Some Isoindoline-1, 3-Dione Derivatives Against Ehrlich’s Ascites Carcinoma Bearing Mice Model”. Jagadish Singh, Tanushree Singha, Arup Naskar, Mrityunjoy Kundu, Ranjit Kumar Harwansh, Arijit Mondal, Tirtha Ghosh and Tapan Kumar Maity. Pharmacologyonline 2: 976-987, (2011).

14. “Evaluation of antitumor activity of stigmasterol,a constituent isolated from Bacopa monnieri Linn aerial parts against Ehrlich Ascites Carcinoma in mice”. Tirtha Ghosh & Tapan Kumar Maity & Jagadish Singh. Oriental Pharmacy and Experimental Medicine. (2011) 11:41–49DOI 10.1007/s13596-011-0001-y.

15. “Synthesis of some novel 3, 5-disubstituted 1, 3, 4-oxadiazole derivatives and anticancer activity on EAC animal model”. Sasmita dash, B Ashok Kumar, Jagadish singh, B C Maiti & Tapan Kumar Maity. Medicinal Chemistry Research, DOI 10.1007/s00044-010-9455-6, 20, 1206-1213, (2011).

16. “Evaluation of Antioxidant Activity of Different Fractions of Melothria maderaspatana”. Ashok Kumar Balaraman, Jagadish Singh, Sasmita Dash, Arup Naskar and Tapan Kumar Maity. Asian Journal of Chemistry; 23(5): 2207-2211, (2011).

17. “Evaluation Of Some Synthesized Novel Substituted Phthalimide Derivatives As Potent Antidiabetic Agents” Mahapatra Shankhapani, Singh Jagadish, Rajapandi Raju, Bhim Charan Maiti, Tapan Kumar Maity. Asian journal of Chemistry 23(4):1581-1584, (2011).

18. “QSAR Analysis of N-Alkyl Phthalimide Analogues As Alpha-Glucosidase Inhibitors”. S. Mahapatra, S.K. Dwivedi, B.C.Maiti, T.K. Maity, S. Manda, A.K. Manna. International Journal of Pharmaceutical and Applied Sciences. 1 (1): (2010).

19. “HPTLC Determination of Phenolic Compounds and Antioxidant Activity of the Aerial Parts of Melothria heterophylla (Lour.) Cogn”. Arijit Mondal, Tapan Kumar

Maity, Dilipkumar Pal, Santanu Sannigrahi, Jagadish Singh, Tirtha Ghosh, G. Nagalakshmi International Journal of Drug Development & Research 2(4) (2010) ISSN 0975-9344.

20. “Design, synthesis and pharmacological screening of hybrid molecules as antihypertensive”. Satarupa Acharjee, Kailash G. Bothara, Shashikant V. Bhandari Tapan Kumar Maity. Medicinal Chemistry Research, DOI 10.1007/s00044-010-9374-6 (2010).

21. “Synthesis and Hypoglycemic Activity of Some Phthalimide Derivatives”. S.P.Mahapatra, P.Ghode, D.K Jain, S.C.Chaturvedi, B.C.Maiti and T.K. Maity. Journal of Pharmaceutical Sciences and Research. 2(9):567-578, (2010).

22. “Antihyperglycemic and hypolipidemic effects of Melothria maderaspatana and Coccinia indica in Streptozotocin induced diabetes in rats”Ashok Kumar B, Jagadish Singh, Sasmita Dash, Tapan Kumar Maity. Saudi Pharmaceutical Journal 18:173–178, (2010).

23. “Synthesis, Anticancer activity of some 1, 3, 4-oxadiazole derivatives against Ehlirch Ascites Carcinoma bearing mice model”. Jagadish Singh, Ashok Kumar B, Rajapandi R, Arijit Mondal, B C Maiti & Tapan Kumar Maity. Pharmacologyonline 1:406-416 (2010).

24. “Evaluation of anticancer activity of some 1, 3, 4-oxadiazole derivatives against Ehlrich Aceites carcimnoma bearing mice. Jagadish Singh, R. Rajapandi, and T K Maity. Asian journal of Chemistry. 22(5): 4099-4103, (2010).

25. “Improved Synthesis of Novel 2, 4-Diamino-5-furfurylpyrimidine in Presence of Molecular Sieves” R. Rajapandi, Jagadish Singh and Tapan Kumar Maity. Asian journal of Chemistry 22(3): 1841-1844, (2010).

26. “Invitro antioxidant activity of the roots of Melothria heterophylla (Lour) Cogn”. Arijit Mondal, Tapan Kumar Maity, Dilipkumar Pal, Santanu Sannigrahi. Pharmacologyonline 2:499-509, (2009).

27. “Evaluation of Antibacterial and Antifungal activity of some 1, 3, 4-Oxadiazoles”Pinaki Sengupta, Mainak mal, Jagadish Singh, Sanchita Mandal and Tapan Kumar Maity.* Iranian Journal of Pharmacology and Therapeutics, 7: 165-167, (2008).

28. “Evaluation of Anticancer Activity of Some 1, 3, 4 Oxadiazole Derivatives” Pinaki Sengupta, Jagadish Singh, Deepak, Kumar Dash, Veerendra C Yeligar, K Murugesh, D Rajalingam, & Tapan Kumar Maity*, Indian Journal of Chemistry , (2008.

29. “Antidiabetic and In Vivo Antioxidant Activity of Ethanolic Extract of Bacopa monnieri Linn”. Aerial Parts: A Possible Mechanism of Action. T Ghosh, Tapan Kumar Maity, P Sengupta, D K Dash, A Bose. Iranian J. Pharmaceutical Research, 7(1):61-68, (2008).

Dr. Pulok Kumar Mukherjee

a) Books:

1. “Evaluation of Herbal Medicinal Products - Perspectives of Quality, Safety and Efficacy”- Pulok K. Mukherjee, Peter J. Houghton, Pharmaceutical Press, Royal Pharmaceutical Society of Great Britain, UK, 2009, 501 pages, ISBN 978-0-85368-751-0.

2. “Quality Control on Herbal Drugs”- Pulok K. Mukherjee, Business Horizons Ltd., New Delhi 2002, 816 pages, ISBN 81-900788-4-4.

3. “GMP in Herbal Drugs” – Pulok K. Mukherjee and Rob. Verpoorte (Edited) Eastern Publishers (Business Horizons Ltd.) New Delhi 2003, 400 pages, ISBN 81-900788-5-2.

4. “Promotion and Development of Botanicals with International Coordination” – Pulok K Mukherjee [Edited], Allied Book Agency, Kolkata, India, 2005, 510 pages.

5. “Traditional Medicines and Globalization–The Future of Ancient Systems of Medicine”- Pulok K. Mukherjee [Edited], Maven Publication, Kolkata, 2014, ISBN 978-81-926243-0-3.

6. “Natural Matrix-Metallo-proteinase Inhibitors - Leads from Herbal Resources”- Pulok K. Mukherjee, NiladriMaity, Neelesh K. Nema, Birendra K. Sarkar in: Studies in Natural Products Chemistry, Elsevier Science Publishers – Amsterdam. 2013, Vol, 36, 91- 113. ISBN: 9780444538379.

7. “Indian Medicinal Plants with Hypoglycemic Potential”- Pulok K. Mukherjee, Neelesh K. Nema, SubrataPandit, Kakali Mukherjee in Bioactive Food as Dietary Interventions for Diabetes, Elsevier Science Publisher, Amsterdam. Editor: RonaldR. Watson, San Diego: Academic Press. 2013, 235-264. ISBN: 978-0-12-397153-1.

8. “Botanicals as Angiotensin Converting Enzyme (ACE) inhibitors Useful in Hypertension”- Pulok K. Mukherjee, Sushil K. Chaudhary, Neelesh K. Nema in: Nutritional and Therapeutic Interventions for Heart Disease, Eds.; Dr NilanjanaMaulik, CRC Press, LLC, Florida. K13877_C029.indd, 2013: 541 -559.

9. “Ayurveda in Modern Medicine: Development and Modification of Bioactivity”- Pulok K Mukherjee,Venkatesh M, Gantait A; In Comprehensive Natural Products-II -Chemistry and Biology, Mander, L., Lui, H.-W., Eds.; Elsevier Science: Oxford, 2010; volume 3, 479–507.

10. “Plant Products with Hypochlesterolemic Potentials” - Pulok K. Mukherjee in: Advanced in Food and Nutrition Research, , Steve L Taylor (Edited), Elsevier Science, USA, 2003, Vol 47, 277-338, ISBN 0-12-016447-7.

11. “Exploring the CNS active potentials of some Indian spices” - N. Satheesh Kumar, Pulok K Mukherjee, S. Bhadra, S. Ponnusankar; In Spices: The Elixir of Life, A.K. De (Eds.) DK Fine Art Press, New Delhi, 2011.

12. “Healthcare through Herbal Medicine- Strategies for Development of Natural Products, Way Forward”- Pulok K. Mukherjee, Neelesh K. Nema, Manoj K. Dalai, Rajarshi Biswas in: Proceeding of National Seminar on Scope & development of Natural Products by Erstwhile Belonia College, South Tripura, India, 2011. ISBN-978-81-89742-51-5.

13. “Exploring Green Resources for Drug Development through Ethno botany”- Pulok K. Mukherjee in: Chemistry for Green Environment, Srivastava MM, Sanghi R (Edited), Narosa Publishing House, New Delhi, India, 2005, 287-301, ISBN 81-7319-620-6.

14. “Evaluation of Botanical-Perspectives of Quality Safety and Efficacy”- Pulok K. Mukherjee and Kakali Mukherjee in: Advances in medicinal plants, Vol 1, N.D. Prajapati, TarunPrajapati and SushmaJaypura (Edited), Asian Medicinal Plants & Health Care Trust, 2005, 87-110, ISBN 89-89070-06-1.

15. “Perspectives of Safety for Natural Health Products” - Pulok K. Mukherjee and Atul Wahile in: Herbal Drugs – A Twenty first Century Perspectives, Rakesh K Sharma and Rajesh Arora (Edited), Jaypee Brothers Medicinal Publishers Ltd., New Delhi, 2006, 50-59, ISBN 81-8061-850-1.

16. “Quality of Natural health products through marker profiling; Promotion and International Coordination”- Pulok K. Mukherjee, V.Kumar, Peter J. Houghton in Ethnopharmacology Recent Trends, P. Pushpangadan, V. George, K.K. Janardhanan (Edited), Daya Publishing House, New Delhi, India, 2008 ,86-99,ISBN10 81-7035-564-8.

17. "Ethno medicine in Complementary Therapeutics" - Pulok K. Mukherjee, S.Ponnusankar, M Venkatesh in Ethno-medicine: A Source of Complementary Therapeutics, D. Chattopadhyay [Ed], Research Signpost, Trivandrum, Kerala 2010: 29-52 ISBN: 978-81-308-0390-6.

18. “Exploring Pharmacovigilance for Traditional Herbal Medicines” - Pulok K. Mukherjee, S. Ponnusankar, In Comprehensive Bioactive Natural Products, Vol-8, V. K. Gupta [Ed], M/S Studium Press LLC, USA 2010: 248-280

19. “Meandering safety of Natural Health Products” – Pulok K. Mukherjee, M. Venkatesh, A. Wahile, P. Paul, In Recent Advances in Herbal Drug Research and Therapy, A. Ray and K. Gulati [Ed]. I.K. International Publishing House Pvt., Ltd, New Delhi, India 2010: 20-34 ISBN: 978-93-80026-97-8.

b) International Journals: 2010-2014

SL NO List of publications

1. Sauvik Bhattacharyya, Soma Majhi, Bishnu Pada Saha, Pulok K. Mukherjee Chlorogenic acid–phospholipid complex improve protection against UVA induced oxidative stress Journal of Photochemistry and Photobiology B: Biology, 2014, 130, 293–298

2. Sauvik Bhattacharyya, Sk Milan Ahammed, Bishnu Pada Saha, Pulok K. Mukherjee The Gallic Acid–Phospholipid Complex Improved the Antioxidant Potential of Gallic Acid by Enhancing Its Bioavailability AAPS PharmSciTech, 2013, 14 (3),1025-1033

3. Sauvik Bhattacharyya, Sk Milan Ahmmed, Bishnu Pada Saha and Pulok K Mukherjee Soya phospholipid complex of mangiferin enhances its hepatoprotectivity by improving its bioavailability and pharmacokinetics Journal of the Science of Food and Agriculture, 2013, DOI 10.1002/jsfa.642

4. Manoj K. Dalai, SantanuBhadra, ArunBandyopadhyay, Pulok K. Mukherjee Evaluation of anti-cholinesterase activity of the standardized extract of Piper betel L. leaf Oriental Pharmacy and Experimental Medicine, 2013, DOI 10.1007/s13596-013-0141-3.

5. Sushil Kumar Chaudhary, Niladri Maity, Santanu Bhadra, Neelesh Kumar Nema, B. P. Saha. Pulok K. Mukherjee , Angiotensin Converting Enzyme inhibition activity from the essential oils of Indian spices Natural Product Communications, 2013, 8, 671 – 672

6. Sushil Kumar Chaudhary, Pulok K Mukherjee, Niladri Maiti, Apurba Kumar De, Santanu Bhadra & Bishnu Pada Saha, Evaluation of Angiotensin converting enzyme inhibition and anti-oxidant activity of Piper longum L.Indian Journal of Traditional Knowledge, 2013, 12, 478-482

7. Sonali Das, Hemanta Mukherjee, SK Milan Ahmed, Pallab K. Haldar, Asit B. Mandal, Ambikesh Mahapatra, Pulok K Mukherjee, Sekhar Chakraborti, and Debprasad Chattopadhyay, Evaluation of an ethnomedicinal combination containing Semecarpuskurzii and Hernandiapeltata used for the management of inflammation Pharmaceutical Biology, 2013, 51, 677-685

8. Neelesh K. Nema, Niladri Maity, Birendra K. Sarkar and Pulok K. Mukherjee. Matrix Metalloproteinase, Hyaluronidase&Elastase Inhibitory Potential of Standardized extract of Centellaasiatica (L.) Pharmaceutical Biology, 2013, 51, 1182-1187

9. Mukherjee, H., Ojha, D., Bag, P., Chandel, H.S., Bhattacharyya, S., Chatterjee, T.K., Mukherjee, P.K., Chattopadhyay, D.Anti-herpes virus activities of Achyranthesaspera: An Indian ethnomedicine, and its triterpene acid, Microbiological Research, 2013, 168, 238–244

10. Pulok K. Mukherjee, Neelesh K. Nema, Niladri Maity, B. Sarkar, Phytochemical and Therapeutic Potential of Cucumber. Fitoterapia, 2013, 84, 227–236

11. Pulok K. Mukherjee, Neelesh K. Nema, P. Venkatesh, Pratip K. Debnath, 2012, Changing scenario for promotion and development of Ayurveda - way forward., Journal of Ethnopharmacology, 2012, 143, 424-434

12. NiladriMaity, Neelesh K. Nema, Birendra K. Sarkar, Pulok K. Mukherjee , Standardized Clitoriaternatea Leaf Extract as Hyaluronidase, Elastase and Matrix-metalloproteinase-1 Inhibitor , Indian Journal of Pharmacology, 2012. 2012, 44(5), 584-587. Med Know Publication

13. Neelesh K. Nema, NiladriMaity, Birendra K. Sarkar and Pulok K. Mukherjee., Determination of trace and heavy metals in some commonly used medicinal herbs in Ayurveda ,Toxicology and Industrial Health 2012, Sage Publication DOI: 10.1177/ 0748233712468015.

14. S. K. Chaudhary, Pulok K. Mukherjee, Neelesh Kumar Nema, Santanu Bhadra, B. P. Saha. ACE inhibition activity of standardized extract and fractions of Terminaliabellerica. , Oriental Pharmacy & Experimental Medicine 2012, 12, 273–277

15. Gantait, A., Maji, A., Barman, T., Banerji, P., Venkatesh, P., Mukherjee, P.K. Estimation of capsaicin through scanning densitometry and evaluation of different varieties of capsicum in India, Natural Product Research 2012, 26 (3), 216-222

16. S. Pandit, Pulok. K. Mukherjee. K Mukherjee, Rahul Gajbhiye, M. Venkatesh, S. Ponnusankar, Santanu Bhadra., Cytochrome P450 Inhibitory Potential of Selected Indian Spices-Possible Food Drug Interaction ,Food Research International, 2012, 45 (1), 69–743.005 2013

17. SantanuBhadra, Pulok K. Mukherjee, A. Bandyopadhyay ,Cholinesterase inhibition activity of Marsileaquadrifolia Linn. an edible leafy vegetable from West Bengal, India , Natural Product Research, 2012, 26 (16) , 1519-1522

18. NiladriMaity, Neelesh K. Nema, Mythies K. Sellamuthu, Birendra K. Sarkar, Pulok K. Mukherjee , Simultaneous Estimation of Hydroxychavicol and Chlorogenic Acid from Piper betel L. through RP-HPLC, Natural Product Research, 2012 , 26 (20), 1939–1941

19. Pulok K Mukherjee, NiladriMaity, Neelesh K Nema, Birendra K Sarkar, Bioactive compounds from natural resources against skin aging.Phytomedicine, 2011, 9 (1), 64-73

20. Pulok K. Mukherjee,Ponnusankar S, Pandit S, Hazam PK, Ahmmed M, Mukherjee K. Botanicals as medicinal food and their effects on drug metabolizing enzymes , Food Chem Toxicol., 2011,49(12), 3142-53.

21. Nurul, I.M, Mizuguchi, H., Shahriar, M. Venkatesh, P, Maeyama, K., Pulok K. Mukherjee, Hattori, M. M S K Choudhari, N Takeda, Fukui, H , Albizialebbeck suppresses histamine signaling by the inhibition of histamine H 1 receptor and histidine decarboxylase gene transcriptions , International Immunopharmacology 2011, 11 (11), 1766-1772

22. Gantait A., Barman T., Pulok K. Mukherjee ,Validated method for estimation of curcumin in turmeric powder. Indfina Journal of Traditional Knowledge, 2011, 10(2), 247-250

23. NiladriMaity, Neelesh K. Nema, Md. Karim Abedy, Birendra K. Sarkar, Pulok K. MukherjeeExploring Tageteserecta Linn flower for the elastase, hyaluronidase and MMP- 1inhibitory activity, Journal of Ethnopharmacology, 2011, 137, 1300– 1305

24. Pulok K. Mukherjee, S. Ponnusankar, P. Venkatesh , Synergy in Herbal Medicinal Products: Concept to Realization, Indian Journal of Pharmaceutical Education and Research, 2011, 45(3), 210 -217

25. S Pandit, A Bandyopadhyay, S Ponnusankar, Sarda Ota, Pulok. K. Mukherjee , Exploring the possible metabolism mediated interaction of Glycyrrhizaglabra extract with CYP3A4 and CYP2D6 ,Phytotherapy Research, 2011 , 25 (10) , 1429-1434

26. S Pandit, Pulok K. Mukherjee, Arunava Gantait, S Ponnusankar and Santanu Bhadra, Quantification of α-asarone in Acoruscalamus by Validated HPTLC densitometric method , Journal of Planar Chromatography - Modern TLC, 2011, 24 (6), 541-544

27. PichairajanVenkatesh, Pulok K. Mukherjee,Bikas C. Pal , Acridanone Alkaloid in Baliospermummontanum– Evaluation of Its Effect against Anaphylaxis , PlantaMedica, 2011, 77: 1–3

28. Kakali Mukherjee, M. Venkatesh, P. Venkatesh, B.P. Saha, Pulok K. Mukherjee , Effect of soy phosphatidyl choline on the bioavailability and nutritional health benefits of resveratrol. ,Food Research International, 2011, 44, 1088-1093.

29. Nema NK, Maity N., Sarkar B, Mukherjee PK , Cucumissativus fruit-potential antioxidant, anti-hyaluronidase, and anti-elastase agent , Arch of Dermatology Research, 2011, 303(4), 247-52.

30. S. Ponnusankar, SubrataPandit, R. Babu, A. Bandyopadhyay, Pulok K. Mukherjee. Cytochrome P 450 inhibitory potential of triphla-a rasayana from Ayurveda , Journal of Ethnopharmacology, 2011, 133 (1), 120-125

31. S. Ponnusankar, S. Pandit, M. Venkatesh, A. Bandyopadhyay, Pulok K. Mukherjee. ,Cytochrome P450 Inhibition Assay for Standardized Extract of TerminaliachebulaRetz. ,Phytotherapy Rresearch, , 2011, 25, 151–154.

32. Pulok K Mukherjee, S Ponnusankar, P Venkatesh, A Gantait, B C Pal , Marker profiling: An approach for quality evaluation of Indian Medicinal Plants Drug Information Journal, 2011, 45, 1-14.

33. P. K. Mukherjee, Satheeshkumar, N.; Venkatesh, P.; Venkatesh, M. ,Lead Finding for Acetyl Cholinesterase Inhibitors from Natural Origin: Structure Activity Relationship and Scope ,Mini Reviews in Medicinal Chemistry, 2011, 11(3), 247-262.

34. Bhadra S, Mukherjee PK, Kumar NS, Bandyopadhyay A. , Anticholinesterase activity of standardized extract of Illiciumverum Hook. f. fruits ,Fitoterapia, 2011, 82, 342-346.

35. S Pandit, Pulok K Mukherjee, S Ponnusankar, M Venkatesh, N Srikanth ,Metabolism mediated interaction of α- asarone and Acoruscalamus with CYP3A4 and CYP2D6 ,Fitoterapia, 2011, 82, 369-74.

36. S Pandit, Mythies Kumar, Ponnusankar S, BC Pal, Pulok K Mukherjee ,RP-HPLC-DAD for simultaneous estimation of Mahanine and Mahanambine in Murraya Koenigii, Biomedical Chromatography 2011, 25 (9), 959-962.

37. KuntalMaiti, Kakali Mukherjee, Venkatesh Murugan, Bishnu Pada Saha, Pulok K. Mukherjee , Enhancing bioavailability and hepatoprotective activity of andrographolide from Andrographis paniculata, a well-known medicinal food, through its herbosome ,Journal of Science and Food Agriculture, 2010, 90, 43–51.

38. .P. Venkatesh, Debajyoti Mukherjee, Pulok K Mukherjee, A Bandyopadhyay, H Mizuguchi, H Fukui ,Potential of Baliospermum montanum against compound 48/80 induced systemic anaphylaxis in mice ,Pharmaceutical Biology, 2010, 48 (11), 1213-1217.

39. P. K. Mukherjee, P. Venkatesh, S. Ponnusankar ,Ethnopharmacology and integrative medicine – Let the history tell the future ,Journal of Ayurveda and Integrative Medicine, 2010, 1, 100-109

40. A. Gantait, S. Pandit. Neelesh K. Nema, Pulok K. Mukherjee ,Quantification of glycyrrhizin in Glycyrrhiza glabra extract by validated HPTLC densitometry ,J. AOAC International, 2010, 93(2), 492-495

41. Gantait A, Roy P, Nema NK, Dutta PK, Mukherjee PK. A validated method for standardization of the bark of Clerodendron serratum. ,Natural Product Communication, 2010, 5(6), 863-866

42. Arunava Gantait, Amita Sahu, P. Venkatesh, P.K. Dutta, Pulok. K. Mukherjee ,Isolation of Taraxerol from Coccinia grandis, and Its standardization ,Journal of Planar Chromatography, 2010, 23 (5), 323–325

43. Debajyoti Mukherjee, N. Satheesh Kumar, Taraknath Khatua, Pulok K Mukherjee ,Rapid validated HPTLC method for estimation of Betulinic acid in Nelumbonucifera (Nympahaeaceae) rhizome extract ,Phytochemical Analysis, 2010, 21, 556-560

44. Debajyoti Mukherjee, Tarak NathKhatua, P. Venkatesh, B.P. Saha, Pulok K. Mukherjee ,Immunomodulatory potential of rhizome and seed extracts of Nelumbo nucifera Gaertn ,Journal of Ethnopharmacology, 2010, 128 (2), 490-494.

45. D Mukherjee, A Biswas, S Bhadra, Venkatesh Pichairajan, Tapas Biswas, Bishnu Pada Saha, Pulok K. Mukherjee ,Exploring the potential of Nelumbonucifera

rhizome on membrane stabilization, mast cell protection, nitric oxide synthesis and expression of costimulatory molecules ,Immunopharmacology and Immunotoxicology, 2010, 32(3), 466-472.

46. Pulok K Mukherjee, P Venkatesh, M Venkatesh, S Ponnusankar, Y Khan ,Strategies for Revitalization of Traditional Medicine ,Chinese Herbal Medicines,2010, 2 (1) 1-15.

47. N. SatheeshKumar, Pulok K. Mukherjee, S. Bhadra, B. P. Saha., B. C. Pal ,Acetylcholinesterase inhibitory potential of a carbazole alkaloid, mahanimbine, from Murraya koenigi ,Phytotherapy Research, 2010, 24(4), 629-631.

48. N. Satheesh Kumar, Pulok K. Mukherjee, S. Bhadra and B. P. Saha , Acetylcholinesterase enzyme inhibitory potential of standardized extract of Trigonellafoenumgraecum L and its constituents ,Phytomedicine, 2010, 17(3-4), 292-295.

49. P. Venkatesh, Pulok K Mukherjee, N. Satheesh Kumar, A. Bandyopadhyay, Hiroyuki Fukui, Hiroyuki Mizuguchi, Nurul Islam ,Anti-allergic activity of standardized extract of Albizia lebbeck with reference to catechin as a phytomarker , Immunopharmacology and Immunotoxicology 2010, 32 (2), 272-276.

Prof. Biswanath Sa,

SL NO

PAPERS

1. Raghabendra V kulkarny and Biswanath Sa. Enteric delivery of ketoprofen through functionally modified poly (acrylamide-grafted-xanthan)-based pH sensitive hydrogel beads: Preparation and in-vitro and in-vivo evaluation.,Journal of Drug Targeting, 2008; 16,167-177.

2. Sabyasachi Maiti, Somasree Ray, Biswanath Sa. Effect of formulation variables on entrapment efficiency and release characteristics of bovine serum albumin from carboxymethyl xanthan microparticles.,Polymer in Advances Technology,2008. 19(7), 922-927.

3. R.V.Kulkarni and B.Sa. Novel pH-sensitive (Polyacryamide-grafted-sodium alginate)-carboxymethylcellulose interpenetrating network hydrogel beads for the controlled release of ketoprofen: Preparation and characterization. Current Drug Delivery, 2008, 5(4), 256-264.

4. R.V.Kulkarni and B. Sa. ,Evaluation of pH-sensitivity and drug release characteristics of (Polyacrylamide-grafted-xanthan)-carboxymethylcellulose pH-sensitive interpenetrating network hydrogel beads. ,Drug Dev. Ind. Pharmacy, 2008, 34 (12), 1406-1414.

5. Somasree Ray, Sabyasachi Maiti and Biswanath Sa. Preliminary Investigation on the Development of Diltiazem Resin Complex Loaded Carboxymethyl Xanthan BeadsAAPS ,PharmSciTech, (2008). 9(1), 295-301.

6. Sabyasachi Maiti, and Biswanath Sa.Preparation and characterization of ibuprofen-loaded alginate microspheres using ethylenediamine as a crosslinker. Oriental Pharmacy and Experimental Medicine, 2008,8(2), 178-186.

7. R.V.Kulkarni, B.Sa. (2009). Journal of Biomaterials Science Polymer Edition. Journal of Biomaterials Science. Polymer Edition, 20 (2), 235-251., Polyacrylamide-grafted-alginate-based pH-sensitive hydrogel beads for delivery of ketoprofen to the intestine: in-vitro and in-vivo evaluation.

8. D.Ghosh Dastidar, B.Sa. (2009). and Propylene Glycol. Comparative Study of UV Spectrophotometry and First Order Derivative UV Spectrophotometry Methods for the Estimation of Diazepam in Presence of Tween-20, AAPS PharmSciTech

9. Tapan Kumar Giri and Biswanath Sa. (2009) , Statistical Evaluation of Influence of Polymers Concentration on Disintegration Time and Diazepam Release from Quick Disintegrating Rapid Release Tablet. YAKUGAKU ZASSHI, 129, 1069-1075

10. Soundrapandian C, Sa B, Datta S. (2009). Organic-inorganic composites for bone drug delivery. AAPS PharmSciTech, 10, 1158-71.

11. Sabyasachi Maiti, Paramita Dey, Santanu Kaity, Somasree Ray, Sushomasri Maji, Biswanath Sa. (2009). Investigation on Processing Variables for the Preparation of Fluconazole-Loaded Ethyl Cellulose Microspheres by Modified Multiple Emulsion Technique. AAPS PharmSciTech, 10(3), 703-715

12. Sanchita Mandal, Sanat Kumar Basu, and Biswanath Sa, (2009). Sustained release of a water soluble drug from alginate matrix tablets prepared by wet granulation method, AAPS PharmSciTech, 10(4), 1348-1356

13. Raghavendra V. Kulkarni, C. Mallikarjun Setty and Biswanath Sa. (2010)..Polyacrylamide-g-alginate based electro-responsive hydrogel for drug delivery application: Synthesis, characterization and formulation development, Journal of Applied Polymer Science, 115 (2), 1180-1188

14. Rashmi Boppana, Raghavendra V. Kulkarni, Srinivas S. Mutalik, C. Mallikarjun Setty and Biswanath Sa. (2010). Interpenetrating network hydrogel beads of carboxymethylcellulose and egg albumin for controlled release of lipid lowering drug. Journal of Microencapsulation, 27 (4), 337-344.

15. Somasree Ray, Sabayasachi Maiti, Biswanath Sa. (2010). Polyethyleneimine-treated xanthan beads for prolonged release of diltiazem: In vitro and in vivo evaluation, Archives of Pharmaceutical Research. 2010, 33, 575-583.

16. Swapnil M. More, Raghavendra V. Kulkarni, Biswanath Sa, Navanath V. Kayane. (2010). Glutaraldehyde crosslinked poly (vinyl alcohol) hydrogel discs for controlled release of anti-diabetic drug, Journal of Applied Polymer Science, 116, 1732-1738.

17. Tapan Kumar Giri, Biswanath Sa. (2010). Preparation and evaluation of rapidly disintegrating fast release tablet of diazepam-hydroxypropyl-β-cyclodextrin inclusion complex, Pharmacology and pharmacy, 1, 18-26

18. Soundrapandian C, Datta S, Kundu B, Basu D, Sa B. (2010).. Porous bioactive glass scaffolds for local drug delivery in osteomyelitis: Development and invitro

characterization AAPS PharmSciTech, doi: 10.1208/s12249-010-9550-5

19. Sanchita Mandal, Rajat Ray, Sanat Kumar Basu, and Biswanath Sa. (2010). Evaluation of matrix tablet prepared with polyacrylamide-g-sodium alginate copolymers and their partially hydrolyzed copolymers for sustained release of diltiazem hydrochloride. .Journal of Biomaterial Science-polymer edition, 21: 1799-1814

20. Sanchita Mandal, Sanat Kumar Basu, and Biswanath Sa. (2010).Ca2+ ion cross-linked interpenetrating network matrix tablets of polyacrylamide-grafted-sodium alginate and sodium alginate for sustained release of diltiazem hydrochloride. Carbohydrate Polymer, 82: 867-873

21. Rajat Roy, Siddhartha Maity, Sanchita Mandal, Tapan Kumar Chatterjee and Biswanath Sa. (2010).Development and Evaluation of a New Interpenetrating Network bead of Sodium Carboxymethyl Xanthan and Sodium Alginate for Ibuprofen Release Pharmacology & Pharmacy, 1, 9-17

22. Ray S, Banerjee S, Maiti S, Laha B, Barik S, Sa B, Bhattacharyya UK. (2010). Novel interpenetrating network microspheres of xanthan gum-poly (vinyl alcohol) for the delivery of diclofenac sodium to the intestine--in vitro and in vivo evaluation. Drug Deliv, 17 (7):508-19.

23. Ruhidas B, Pramanik KC, Ray R, Pal T, Sa B, Chatterjee TK. (2010). Pharmacological activities of diclofenac sodium-loaded microspheres (DSMSs) in rats. Int J Biomed Pharm Sci., 4(1), 48-53.

24. Kulkarni, R.V., Sreedhar, V., Mutalik, S. Setty, C.M., Sa, B. (2010). Interpenetrating network hydrogel membranes of sodium alginate and poly(vinyl alcohol) for controlled release of prazosin hydrochloride through skin,International Journal of Biological Macromolecules, 47( 4), 520-527.

25. Maiti, S., Ranjit, S., Sa, B. (2010). Polysaccharide-based graft copolymers in controlled drug delivery, International Journal of Pharm Tech Research, 2 (2), 1350-1358.

26. Rajat Roy, Siddhartha Maity, Sanchita Mandal, Tapan Kumar Chatterjee and Biswanath Sa. (2011). Studies on the release of ibuprofen from Al3+ ion cross-linked homopolymeric and interpenetrating network hydrogel beads of carboxymethyl xanthan and sodium alginate.. Advances in polymer technology, 30 (1), 1-11

27. Maiti, S., Kaity, S., Ray, S., Sa, B. (2011). Development and evaluation of xanthan gum-facilitated ethyl cellulose microsponges for controlled percutaneous delivery of diclofenac sodium, Acta Pharmaceutica, 61(3), 257-270.

28. Kulkarni, R.V. , Mangond, B.S., Mutalik, S., Sa, B. (2011). Interpenetrating polymer network microcapsules of gellan gum and egg albumin entrapped with diltiazem-resin complex for controlled release application, Carbohydrate Polymers, 83 (2), 1001-1007.

29. Soundrapandian, C., Basu, D., Sa, B., Datta, S. (2011). Local drug delivery system for the treatment of osteomyelitis: In vitro evaluation, Drug Development and Industrial Pharmacy, 37(5), 538-546.

30. Maiti, S., Ranjit, S., Mondol, R., Ray, S., Sa, B. (2011). Al +3 ion cross-linked and acetalated gellan hydrogel network beads for prolonged release of glipizide,Carbohydrate Polymers, 85(1), 164–172.

31. Maiti, S., Paul, S., Mondol, R., Ray, S., Sa, B. (2011). Nanovesicular formulation of brimonidine tartrate for the management of glaucoma: in vitro and in vivo evaluation, AAPS PharmSciTech, 12 (2), 755-763.

32. Kulkarni, R.V. , Wagh, Y.J., Setty, C.M., Sa, B. (2011). Development and characterization of sodium alginate-hydroxypropyl methylcellulose-polyester multilayered hydrogel membranes for drug delivery through skin,.Polymer - Plastics Technology and Engineering, 50 (5), 490-497

33. Kulkarni, R.V , Baraskar, V.V, Setty, C.M, Sa, B. (2011). Interpenetrating polymer network matrices of sodium alginate and carrageenan for controlled drug delivery application, Fibers and Polymers, 12 (3), 352-358.

34. Chakraborty, S, Mitra, M.K, Chaudhuri, M.G, Sa, B, Das, S, Dey, R. (2012). Study of the Release Mechanism of Terminalia chebula Extract from Nanoporous Silica Gel, Applied Biochemistry and Biotechnology, 168 (7), 2043-2056.

35. Maiti, S , Ghosh, S, Mondol, R, Ray, S, Sa, B. (2012). Smart reticulated hydrogel of functionally decorated gellan copolymer for prolonged delivery of salbutamol sulphate to the gastro-luminal milieu, Journal of Microencapsulation, 29(8), 747-758.

36. Raghavendra V Kulkarni, Ravindra P. Birajdar and Biswanath Sa. (2012), Sonophoresis and Iontophoresis mediated transdermal penetration of Prednisolone acetate from topical hydrogels Drug Delivery Letters, 2, 146-154.

37. Maiti, S. , Chowdhury, M., Datta, R., Ray, S., Sa, B. (2013). Novel gastro ulcer protective micro (hydro) gels of sulfated locust bean gum-aluminium complex for immediate release of diclofenac sodium, Journal of Drug Targeting, 21(3), 265-276.

38. Dey, P, Maiti, S., Sa, B. (2013). Gastrointestinal delivery of glipizide from carboxymethyl locust bean gum-Al3+-alginate hydrogel network: In vitro and in vivo performance, Journal of Applied Polymer Science, 128 (3), 2063-2072

39. R.V.Kulkarni, V.V.Baraskar, V.V. Alange, A.A. Naikawadi, Biswanath Sa. (2013). Controlled release of an antihypertensive drug through interpenetration polymer network hydrogel tablets of tamarind seed polysaccharide and sodium alginate, Journal of Macromolecular Science, Part B: Physics, 52, 1636-1650

40. Paramita Dey, Sabyasachi Maiti, Biswanath Sa. (2013). Novel etherified locust bean gum-alginate hydrogel for controlled release of glipizide, Journal of Material science. Polymer Edition, 24, 663-683

41. Sabyasachi Maiti, Moumita Chowdhury, Rana Datta, Somasree Ray, Biswanath Sa. (2013). Novel gastroulcer protective micro (hydro) gels of sulfated locust bean gum-aluminium complex for immediate release of diclofenac sodium, Journal of Drug Targeting, 21 (3), 265-276.

42. Rakesh Singh, Siddhartha Maity, Biswanath Sa. (2014). Effect of ionic crosslink on the release of metronidazole from partially carboxymethylated guar gum tablet Carbohydrate Polymers, http://dx.doi.org/10.1016/j.carbpol.2014.01.033.

Dr.Tuhinadri Sen SL NO

PAPERS

1. Ganguly D, Sarkar R, Santra RC, Deb T, Sen T, Das , Synthesis and characterization of 5-amino-2-((3-hydroxy-4-((3-hydroxyphenyl) phenyl) diazenyl) phenol and its Cu(II) complex – a strategy toward developing azo complexes for reduction of cytotoxicity. Complex Met. 2014, Vol, 1–10

2. Bera R, Ahmed SK, Sarkar L, Sen T, Karmakar S. Pharmacokinetic analysis and tissue distribution of andrographolide in rat by a validated LC-MS/MS method. Pharm Biol. 2014 Mar; 52(3):321-9. doi: 10.3109/13880209.2013.836544

3. Sarkar L, Bera R, Sen T, Karmakar S.Comparative Study Of The Fractions Of A Relatively Unexplored Plant- Byttneria Herbacea On Histaminergic, Int J Pharm Pharm Sci. 2013 5(3), 862-866

4. Pattnaik A, Sarkar R, Sharma A, Yadav KK, Kumar A, Roy P, Mazumder A, Karmakar S, Sen T. Pharmacological studies on Buchanania lanzan Spreng.- a focus on wound healing with particular reference to anti-biofilm properties. Asian Pac J Trop Biomed. 2013 Dec;3(12):967-74. doi: 10.1016/S2221-1691(13)60187-2

5. Barik R, Sarkar R, Biswas P, Pattnaik A, Samanta SK, Mani Senthil Kumar KT, Karmakar S, Sen T.: 41-49, Inhibition of arachidonic acid metabolism and pro-inflammatory cytokine production by Bruguiera gymnorrhiza leaf, Orient Pharm Exp Med 2013; 13

6. Nayak DK, Halder KK, Baishya R, Sen T, Mitra P, Debnath MC. Tricarbonyltechnetium(I) and tricarbonylrhenium(I) complexes of amino acids: crystal and molecular structure of a novel cyclic dimeric Re(CO)3-amino acid complex comprised of the OON donor atom set of the tridentate ligand. Dalton Trans. 2013 Oct 7;42(37):13565-75. doi: 10.1039/c3dt50928a

7. Karmakar S, Padman A, Swamy Mane N, Sen T. Hypokalemia: a potent risk for QTc prolongation in clarithromycin treated rats. Eur J Pharmacol. 2013 Jun 5;709(1-3):80-4.

8. Nayak DK, Baishya R, Halder KK, Sen T, Sarkar BR, Ganguly S, Das MK, Debnath MC.Evaluation of (99m)Tc(i)-tricarbonyl complexes of fluoroquinolones for targeting bacterial infection., Metallomics. 2012 Nov;4(11):1197-208. doi: 10.1039/c2mt20132a. Epub 2012 Oct 16.

9. Mani Senthil Kumar KT, Puia Z, Samanta SK, Barik R, Dutta A, Gorain B, Roy DK, Adhikari D, Karmakar S, Sen T. The Gastroprotective Role of Acanthus ilicifolius - A Study to Unravel the Underlying Mechanism of Anti-Ulcer Activity. Sci Pharm. 2012 Sep;80(3):701-17. Epub 2012 Jun 18.

10. Sarkar L, Bhuvaneswari N, Samanta SK, Islam MN, Sen T, Fukui H, Mizuguchi H, Karmakar S. A report on anti-oedemogenic activity of Byttneria herbacea roots--possible involvement of histamine receptor (type I). J Ethnopharmacol. 2012 Mar 27;140(2):443-6.

11. Arcemisbéhère L, Sen T, Boudier L, Balestre MN, Gaibelet G, Detouillon E, Orcel H, Mendre C, Rahmeh R, Granier S, Vivès C, Fieschi F, Damian M, Durroux T, Banères JL, Mouillac B. .Leukotriene BLT2 receptor monomers activate the G(i2) GTP-binding protein more efficiently than dimmers, J Biol Chem. 2010 Feb 26;285(9):6337-47.

12. Arumugam M, Mitra A, Jaisankar P, Dasgupta S, Sen T, Gachhui R, Kumar Mukhopadhyay U, Mukherjee, Isolation of an unusual metabolite 2-allyloxyphenol from a marine actinobacterium, its biological activities and applications., J. Appl Microbiol Biotechnol. 2010 Mar;86(1):109-17.

13. Lahiri S, Sen T, Palit G. Involvement of glucocorticoid receptor and peroxisome proliferator activated receptor-gamma in pioglitazone mediated chronic gastric ulcer healing in rats. Eur J Pharmacol. 2009 May 1;609(1-3):118-25

14. Mani Senthil Kumar KT, Gorain B, Roy DK, Zothanpuia, Samanta SK, Pal M, Biswas P, Roy A, Adhikari D, Karmakar S, Sen T. Anti-inflammatory activity of Acanthus ilicifolius. J Ethnopharmacol. 2008 Oct 30;120(1):7-12.

15. Roy DK, Kumar KT; Zothanpuia, Karmakar S, Pal S, Samanta SK, Adhikari D, Sen T. Pharmacological studies on Indian black tea (leaf variety) in acute and chronic inflammatory conditions. Phytother Res. 2008 Jun;22(6):814-9.

16. Sarkar S, Saha M, Roy D, Jaisankar P, Das S, Gauri Roy L, Gachhui R, Sen T, Mukherjee J. Enhanced production of antimicrobial compounds by three salt-tolerant actinobacterial strains isolated from the Sundarbans in a niche-mimic bioreactor. Mar Biotechnol (NY). 2008 Sep-Oct;10(5):518-26.

17.   Samanta SK, Kumar KT, Roy A, Karmakar S, Lahiri S, Palit G, Vedasiromoni JR, Sen T. An insight on the neuropharmacological activity of Telescopium telescopium--a mollusc from the Sunderban mangrove. Fundam Clin Pharmacol. 2008 Dec;22(6):683-91.

18. Samanta SK, Adhikari D, Karmakar S, Dutta A, Roy A, Manisenthil KT, Roy D, Vedasiromoni JR, Sen T. Pharmacological and Biochemical studies on Telescopium telescopium - a marine mollusk from the Mangrove regions. OPEM; (2008) VOL.8; NO.4; PAGE.386-394 

Books and Proceedings:

1. Contributed chapters in the book entitled Natural Drugs and the Digestive Tract (Eds. F.Capasso and N. Mascolo, EMSI, Roma, 1992).

2. Contributed in the book entitled "Practicing Pharmacist", of the State Pharmacy Council, West Bengal (Published in 1996).

3. Reviewed “Text book of Pharmacology”, (ed. S.D. Seth, Published by B.I. Churchill Livingstone, 1997).

4. Contributed in the book entitled “Pharmacists Desk Reference”, of the State Pharmacy Council, West Bengal (Published in 1998)

5. Progress in Brain Research, (Eds. Poulain et al , 139, 2002).

6. Contributed an artcle “Evaluation of the medicinal properties of Indian Black Tea”, published in the proceedings of the Fourth Workshop of National Tea Research Foundation, 2005.

7. Esterase like enzyme from the tentacle extract of Parachondylactis India Dave. Proceedings of the First International conference on Promotion and development of botanicals with international coordination (Ed. P. K. Mukherjee), Allied Book Agency, Kolkata, 2005.

8. Pharmacological Evaluation of “The Medicinal Properties Of Tea”, published in Medicinal properties of tea (Eds: B. Banerjee and T.C. Chaudhuri), Oxford and IBH publishing Company, New Delhi, India, 2006.

Dr.Sanmoy Karmakar

Research publications:

Sl. No.

Papers

1 Colloids and Surfaces B: Biointerfaces 115 (2014) 286-294- “Nanoemulsion strategy for olmesartan medoxomil improves oral absorption and extended antihypertensive activity in hypertensive rats” ELSEVIER

2 International Journal of Pharmaceutics 460 (2014) 131– 143, “Improvement of cellular uptake, in vitro antitumor activity and sustained release profile with increased bioavailability in the platform of nanoemulsion” - ELSEVIER

3 European Journal of Pharmacology 709 (2013) 80–84, “Hypokalemia: A potent risk for QTc prolongation in clarithromycin treated rats” – ELSEVIER

4 Regulatory Toxicology and Pharmacology 65 (2013) 68–78 “Pharmacokinetics, pharmacodynamics and toxicity of a combination of metoprolol succinate and telmisartan in Wistar albino rats: Safety profiling” – ELSEVIER

5 Pharmaceutical Biology – Oct. (2013) , “Pharmacokinetic analysis and tissue distribution of andrographolide in rat by a validated LC-MS/MS method” Informa Healthcare USA.

6 Oriental Pharmacy and Experimental Medicine (2013), 13:41–49 “Inhibition of arachidonic acid metabolism and pro-inflammatory cytokine production by Bruguiera gymnorrhiza leaf” - Springer

7 Medicinal Chemistry Research (2013) DOI10.1007/s00044-013-0758-2 “Amberlite IRA 402(OH)-mediated synthesis and evaluation of fused tricyclic quinolinium salts as potent non-detergent type microbicidal spermicides” - Springer

8 Journal of Chromatographic Science (2013); 1–7 "Development and Validation of RP-HPLC Method: Scope of Application in the Determination of Oil Solubility of Paclitaxel”– OXFORD UNIVERSITY PRESS

9 Asian Pacific Journal of Tropical Biomedicine (2013), Vol 3(12): 967-974 “Pharmacological studies on Buchanania lanzan Spreng.-A focus on wound healing with particular reference to anti-biofilm properties” – ELSEVIER

10 International Journal of Pharmaceutical Sciences Review and Research Sep. (2013) Vol 22 (2), Article number 14; 69-72 “Comparative pharmacokinetic and relative bioavailability study of ursodeoxycholic acid tablets in healthy Indian volunteers”

11 Chemical Biology and Drug Design (2013), DOI: 10.1111/cbdd.12166, “Synthesis, characterisation and biological evaluation of 99mTc(CO)3labeled peptides for potential use as tumor targeted radiopharmaceuticals” - Wiley

12 International Journal of Pharmacy and Pharmaceutical Sciences (2013) Vol 5, Suppl 3, 862-866, “comparative study of the fractions of a relatively unexplored plant - byttneria herbacea on histaminergic inflammation”

13 Medicinal Chemistry Research (2012) DOI 10.1007/s00044-012-0202-z. (Springer Science) “I2 catalyzed Friedel–Crafts alkylation reaction of substituted anilines with ninhydrin: formation of novel products and their antimicrobial evaluation” - Springer

14 Scientia Pharmaceutica (2012) 80: 701–717, “Gastro-protective role of Acanthus ilicifolius –A study to unravel the underlying mechanism of anti-ulcer activity” - Österreichischer Apotheker-Verlag (Austria)

15 Journal of Ethnopharmacology 140 (2012) 443-446, “A report on anti-oedemogenic activity of Bytteria herbacea herbacea roots- Possible involvement of histamine receptor(type-1)” - ELSEVIER

16 Int. Jr. Pharm. Sci. Res, (2011); Vol.2(3):534-542, “development and validation of a hplc method with uv detector for quantification of gemifloxacine in human plasma :application to bioequivalence study”.

17 Journal of pharmacy Research, (2011); 4(9). 3155 - 3158, “development and validation of a high performance liquid chromatographic method for ulifloxacin and active metabolites of prulifloxacin in human plasma and its application to bioequivalence study”.

18 Journal of Pharmacy Research (2009),2(5),785-788, “The antiulcer activity of Pterospermum acerifolium bark extract in experimental animal”.

19 Int. Jr. Pharmacy and Pharmaceutical Scs .VOL.1.Suppl 1,Nov-Dec. (2009), “effect of pterosperum acrrifolium bark extract on oxidative damages in the gastric tissue during alcohol induced ulcerraton”.

20 Journal of Pharmacy Research (2009), 2(6), 1042-1044, “In vitro antioxidant activity of Petrospermum acerifolium barks”.

21 Jounal of Medicinal Plant Research.Vol.3(5),pp.316-320 May, (2009), “Anti-inflammatory and analgesic activity of bark extract of Petrospermum acerifolium”.

22 FUNDAMENTAL & CLINICAL PHARMACOLOGY, Doi:10.1111/j1472-8206. (2008) 00631.x, “An insight on the neuropharmacological activity of Telescopium telescopium-a mollusk from the Sunderban mangrove” - Wiley

23 Journal of Ethnopharmacology 120 (2008) 7-12, “Anti-infammmatory activity of Acanthus ilicifolius”, - ELSEVIER

24 PHYTOTHERAPY RESEARCH, 22,814-819 (2008), “Pharmacological Studies on Indian Black Tea (leaf variety)in Acute and Chronic Inflammatory Conditions” – Wiley

25 Oriental Pharmacy and Experimental Medicine, (2008) 8(4),386-394, “Pharmacological and Biochemical Studies on Telescopium telescopium –Springer

9.1.6 Relevant Patents in Last 5years

SL NO

Name Patent details

1 Amalesh Samanta

GUM ODINA- AS NEW PHARMACEUTICAL EXCIPIENTS Application No. 61/KOL/2006 dated 20th January, 2006

2 Pulok K Mukherjee

A Process for Isolation of Betulinic Acid useful as Anti-HIV, Anti-tumoral and Melanoma-Specific Cytotoxic Agent” - PulokK.Mukherjee, M. Pal and B.P.Saha by Intellectual Property Management Division, CSIR, New Delhi (International

“A Process of Preparing a Herbal Composition for the Management of Insomnia/Stress and Product thereof’ P. K Mukherjee, S. Rai, Kakali Mukherjee and KFH NazeerAhamed, B.P. Saha and S. Roy Chowdhury, Indian Patent No –221881.

“A Process of Preparing Herbosomes with Andrographolide having Better Hepatoprotective Activity and Product thereof” P.K.Mukherjee, KuntalMaiti, KakaliMukherjee and BishnuPadaSaha; Indian Patent No- 234595.

“Genisteinherbosomes for better therapeutic efficacy” Pulok K Mukherjee, M Venkatesh, Kakali Mukherjee submitted on 9/8/2009 with Intellectual Ventures India, Bangalore.

3

Dr.Tuhinadri Sen

International (France, PCT-WP and US) 1. FR2856407 A1 2. WO2004113539 A2                                                                                                      3. United States 20070149766 

9.1.7 Facilities Available:

a. Central Instrument facility developed under UPE -II :

i. Real Time PCR (Stepone Plus; Life Technologies)

ii. Zetasizer (Nano ZS 90; Malvern)

iii. Multi Mode Microplate Reader (Spectramax M5; Molecular Devices)

iv. Rheometer (MCR 102; Anton Paar)

Softwares - In silico facilities for computer aided drug design: Schrodinger

i. Glide ii. Phase iii. Canvas iv. Prime v. QSITE vi. SITE MAP

Manpower recruited: 13 Project fellows are presently

b. Instrument facilities available with the different members:

SL NO

Name of PI Name of the Equipments

1. Kunal Roy- Schrodinger software, 2012, DTC Lab

2. Pulok Kumar Mukherjee

High Performance Thin Layer Chromatography (HPTLC), CAMAG Linomat III with scanning densitometry LINOMAT V is need for better sample application and chromatographic characterization. Micro plate reader, BIO-RAD, BIORAD Model 680XR micro plate reader (Bio – Rad Laboratories, Inc

High Performance Liquid Chromatography

(HPLC), Waters 600 with UV/VIS detector Shimadzu with PDA Detector Flash Chromatography, Biotage,Biotage Isolera

Preparative HPLC, Shimadzu, Model LC-8A, all the accessories including column are available.

Atomic absorption spectroscopy (AAS) ThermoScientific, AAS303

3. Tuhinadri Sen AKTA Prime - Protein Purification system

Spectrophotometer

ELISA reader (visible)

SDS PAGE / western BLOT assembly

4. Sanmoy Karmakar

HPLC (analytical)

NIBP, BIOPAC

9.1.8 Ongoing Work under UPE II – 2012-14

Dr. Kunal Roy Title: First Report on Exploring Structural Requirements of 1,2,3,4-Tetrahydroacridin-9(10H)-one Analogs as Antimalarials Using Multiple QSAR Approaches: Descriptor-Based QSAR, CoMFA-CoMSIA 3DQSAR, HQSAR and G-QSAR Approaches

Authors: Probir Kumar Ojha and Kunal Roy

Journal Name: Combinatorial Chemistry & High Throughput Screening, 2013, 16, 7-21 Abstract: Due to the emergence of multidrug resistance of malaria parasites, there is an urgent need to modify existing antimalarial drugs through structural changes as well as to search new pharmacophores to counteract the induced resistance. In the present work, different quantitative structure-activity relationship (QSAR) models have been developed using a series of 73 1,2,3,4-tetrahydroacridin-9(10H)-one (THA) analogs with well defined antimalarial activity against W2 clone to provide detailed insight into the main structural fragments that impart antimalarial activity to these molecules. To the best of our knowledge, this is first QSAR report of THA analogs as antimalarials.

Status: Published

Most significant conclusions: • For an enhancement in the antimalarial activity of the molecules: i) R2 position should be

substituted with a bulky group (like phenyl, methoxy, isopropyl, tertiary butyl group) which may be further substituted with electrostatically favored positively charged group; ii) R3 position should be substituted with hydrophobically favoured but sterically disfavored group; iii) R4 position should be substituted with positively charged group lacking any carbon atom and iv) R5 position should be substituted with two methyl groups.

• On the contrary, substitution with bulky group at R6 position may reduce the antimalarial activity.

• Using the developed models, we have designed and proposed some new compounds which showed good in silico predicted activity.

Dr. Amalesh Samanta

Title: Designing Novel pH-Induced Chitosan–Gum Odina Complex Coacervates for Colon Targeting.

Authors: Partha Sarathi Roy, Amalesh Samanta, Manabendra Mukherjee, Bappaditya Roy, Abhishek Mukherjee Name of the Journal/ Conference: Industrial and Engineering Chemistry Research Abstract: This paper investigates the design of novel polyelectrolyte complex (PEC) coacervates of chitosan (Ch) with gum Odina (GO) as potential candidates for colon targeting. Potentiometric titration experiments established that 1:1 charge stoichiometry occurred at a Ch/GO weight ratio of 1:5. The coacervate formed at pH 4.5 displayed the highest storage modulus (G′) values. FTIR, XPS, WAXS, TGA, and DSC results suggested the strong ionic (NH3+···COO−) bond formation between these two biopolymers. Through in vitro viability tests, the pH-induced PECs were shown to be nontoxic. In vitro biodegradation rates of their microspheres revealed insolubility in simulated gastric fluid and simulated intestinal fluid and degradation by cell associated portions of rat cecal and colonic enzymes rather than the extracellular portions. The microsphere of pH 3.0 showed the highest degradation, and LVSEM micrographs revealed notably high amount of macropores in cell-associated enzymes, in contrast to extracellular enzymes. Status: Published (Vol: 52, Page No: 15728-15745; Year: 2013) Most Significant Conclusion(s):

• Gum odina was complexed with chitosan (as evidenced by FTIR, XPS, WAXS, TGA and DSC scans) and the novel polyelectrolyte complex coacervate of gum odina and chitosan was formulated to non-toxic (as evidenced by in vitro viability test) microspheres with high elasto mechanical strength (as evidenced by rheological characterization), which was demonstrated to be colon targeting in nature.

• Odina wodier bark extracts demonstrate antimicrobial potentiality on selected isolates of bacteria, fungi and HSV, associated with skin infection.

Prof. Tapan Kumar Maity Title: Synthesis, characterization and biological evaluation of furfuryl pyrimidine derivatives.

Authors: Benupani Sahu, Dr. Tapan kumar maity,

Status: Work going on SCHEME I:

O COH +NC

OC 2 H 5

O

NC

OC 2 H 5

N a / C H 3 O H , M g

r e f l u x / s t i r r i n g f o r 1 8 h

+

NH 2

NH

H 2 N

C H 3 O H , M S 3 A 0

r e f l u x f o r 2 4 h

N

N

O

NH 2

NH 2

f u r f u a l2 - e t h o x y p r o p i o n i t r i l e

3 - e t h o x y - 2 - ( f u r a n - 2 - y lm e t h y l ) a c r y l o n i t r i l e

g u a n i d i n e

2 , 4 - d i a m i n o - 5 - f u r f u r y l - p y r i m i d i n e

I

Spectral data:

Molecular formula: C9H10N4O Molecular weight: 190.08 Melting point: 169-1710C % of Yield: 65 IR (KBR, (cm-1): 3314(NH), 3139(3130), 2882(CH), 1628(C=N).

Most Significant Conclusion(s):

As pyrimidine is one of the best molecule so far the drug discovery & development concerned we are hope to synthesize some more number of novel pyrimidine molecules which will tried for different biological activity. We shall also try to correlate the in vitro & in vivo activity of the drugs with theirs mechanistic approach. The mechanistic approach will really give some light into the novelty of the research.

Dr. Pulok K Mukherjee

Title: Standardization and chemo profiling of some Indian medicinal plants with their potential enzyme inhibitory activity

Objective: RP-HPLC method development and validation for standardization of Apigenin in Stereospermum sauveolens methanol extract using HPLC/UV

Publication: A research paper in this context is being communicated to J. Food Science, Elsevier.

Methodology:

Preparation of Standard Stock Solutions

About 1 mg of apigenin standard was weighed separately and transferred in 1 mL eppendroff tube. Then the sample was dissolved and make up the volume with methanol. This standard stock solution was stored at 4°C. All samples were filtered through a 0.45µm pore size filter membrane in order to protect the column.

Preparation of calibration curve standards

The linearity was confirmed by establishing a calibration curve with five dilution of each standard. The standard solution of apigenin was prepared in the range of 1-40 µg/mL by serial dilution from stock solution.All solutions were stored in refrigerator (2 to 8ºC).

Preparation of sample solutions

The sample solution was prepared by dissolving the extract in diluent at the concentration of 2mg/ml. These solutions were mixed thoroughly and sonicate for 5 minutes. These solutions were filtered with 0.45 µ syringe filter prior to injection into the system.

Preparation of Mobile Phases

Methanol: 1% Acetic acid in water (55:45 v/v) at pH 2.3

Method validation

The HPLC method was validated by defining the selectivity, linearity, accuracy, precision, LOD and LOQ. Linearity was determined from the regression equation of the calibration curve. The limit of Detection (LOD) and Limit of quantification (LOQ) were calculated based on the ICH guideline by determining the SD of the response and the slope of the linear equation. Accuracy of the method was determined by standard addition technique and expressed in terms of % RSD for mean recovery of the theoretical concentration. The precision of the analytical method was assessed by performing intra-day and inter-day variation, assessed by injecting six replicates at

three different concentrations for the reference compounds. Values were represented as %RSD of intraday and inter-day runs.

Results

The content of the active constituents were determined from the peak areas of the extract obtained from the chromatogram and extrapolated in the calibration curve to determine the corresponding concentration in the extract. The content of apigenin was found to be 0.89% (w/w) in the fruit of Stereospermum sauveolens methanol extract.

Table 1. HPLC Details and Results

Flow rate 1 ml/min LOQ 8.25 ng

Elution Isocratic LOD 2.70 ng

Λmax 349 nm Intra-day precession <2%

Run time 12 min

Intra-day Inter-day precession

<2%<2%<<2%

Retention time (Rt) 6.664 min % Recovery 96%-98% Linearity 1-40 µg/mL Correlation coefficient (R2)

0.993

Regression equation Y=23838X+58264

Supplementary data (HPLC chromatograms)

Fig 1: Typical HPLC/UV chromatogram of Apigenin standard

Fig 2: Typical HPLC/UV chromatogram of Stereospermum sauveolens methanol extract

Objective: Development of kinetics study of eugenol by spectrophotometric method in S. aromaticum plant extract

Methodology:

The activity of the cholinesterase was measured using Spectra Max M5 (Molecular Device) 96-well microplate reader. Each well of the plate contained, 30 µL of 0.5 mM, DTNB, 30 µL of 14 mM ATCI/BTCI (AChE/BChE inhibition), and 25 µL of sample (at various concentrations ranges at 0.75, 1.5, 3.0, 6.0, 7.0, 14.0 µg/mL) were dissolved in phosphate buffer. The absorbance was detected at 405 nm for every 13 s up to 104 s. 25 µLof 0.22U/mL of AChE/BChE solution in phosphate buffer were added into well and the absorbance was again read at the intervals of 13 s for 104 s. The kinetic parameter km (Michaelis–Menten constant), Vmax (maximal velocity) and dissociation constant/inhibition constant (Ki) were calculated over through the Lineweaver–Burk and their secondary plots. The experiment was performed in triplicate.

Results:

Enzyme kinetics of AChE inhibitory activities of methanol extract of S. aromaticum extract, essential oil, eugenol and galantamine are shown in (Table 1 and Figure 6 a, b, c). Vmax, Km and Ki values were determined through Lineweaver–Burk plot. Vmax value (54.09 ± 1.38, 32.72 ± 1.26, 64.06 ± 3.0) of S. aromaticum methanol extract, essential oil and eugenol were decreased with control group (92.76 ± 3.44), while the Km value of above constituents were increased with comparison of same control group (40.99 ± 2.98). However, Vmax value of reference compound galantamine (92.76 ± 3.44) showed any significant change in respect of control group. Moreover, eugenol and galatamine were shown significant (P < 0.05) kinetic value, when it compared with control group. In the case of BChE, the results of all test compounds were shown in (Table 1 and Figure 7 a, b, c). Vmax value of S. aromaticum methanol extract, essential oil and eugenol

(61.54 ± 2.83, 68.44 ± 1.29, 58.62 ± 2.83) were significantly increased by comparing control group (68.18 ± 3.8), while Km value of these test compounds were remain unchanged. Further, the reference compound galantamine was shown increase in Vmax value (48.59 ± 0.9) with decrease in Km value (25.57 ± 2.1) by comparing Vmax value (68.18 ± 3.8) and Km value (24.11 ± 2.7) of control group. Data results also indicated that galantamine have significant (P < 0.05) value than the control group. In case of AChE activity, Ki value of galantamine exhibit 1.761 ± 0.2, which was less in value of remaining test chemical compounds. Further, Ki value (2.545 ± 0.49) of galantamine for BChE inhibition was also decreases with other test compounds.

Table 1: Summary of kinetic data

* P < 0.05 vs. control # P < 0.05 vs. Standard ##n mole/min/mg of protein

Enzyme Substrate Inhibitor Vmax km (mM) Ki (mg/ml) Type of inhibition

Acetyl cholinesterase

ATCI Control 92.76 ± 3.44

40.99 ± 2.98

Nil Nil

ATCI Galantamine 92.76 ± 3.44

42.23 ± 4.0*

1.761 ± 0.2 Competitive

ATCI Eugenol 64.06 ± 3.0 44.70 ± 5.5#

33.78 ± 4.2 Mixed

ATCI Methanol extract

54.09 ± 1.38

46.689 ± 0.56

59.19 ± 3.11

Mixed

ATCI Clove oil 32.72 ± 1.26

46.889 ± 0.59

57.23 ± 4.66

Mixed

Butyryl cholinesterase

BTCI Control 68.18 ± 3.8 24.11 ± 2.7

Nil Nil

BTCI Galantamine 48.59 ± 0.9 25.57 ± 2.1*

2.545 ± 0.49

Mixed

BTCI Eugenol 58.62 ± 4.7 24.11 ± 2.7

9.617 ± 2.0 Non- Competitive

BTCI Methanol extract

61.54 ± 2.83

24.11 ± 2.7

67.2 ± 3.83 Non- Competitive

BTCI Clove oil 68.44 ± 1.29

24.11 ± 2.7

71 .5 ± 4.33

Non- Competitive

The data were analyzed by one way ANOVA. Values are Mean ± SEM, N= 6 (N= Number of replicates)

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with would owed pe of n the red as

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ant to eving result ction. ies of trains

(Gram +ve and Gram – ve) including drug resistant strains (the study will be based on traditional usage).

1. Screening for antimicrobial activity and subsequently to evaluate against biofilm formation and preformed biofilms.

2. To study the effect on QS pathway.

3. Studies on membrane damage (using prokaryotic systems) and artificial biomembranes

Publications :

Ganguly D, Sarkar R, Santra RC, Deb T, Sen T, Das , Synthesis and characterization of 5-amino-2-((3-hydroxy-4-((3-hydroxyphenyl) phenyl) diazenyl) phenol and its Cu(II) complex – a strategy toward developing azo complexes for reduction of cytotoxicity. Complex Met. 2014, Vol, 1–10.

Bera R, Ahmed SK, Sarkar L, Sen T, Karmakar S. Pharmacokinetic analysis and tissue distribution of andrographolide in rat by a validated LC-MS/MS method. Pharm Biol. 2014 Mar; 52(3):321-9. doi: 10.3109/13880209.2013.836544

Sarkar L, Bera R, Sen T, Karmakar S.Comparative Study Of The Fractions Of A Relatively Unexplored Plant- Byttneria Herbacea On Histaminergic, Int J Pharm Pharm Sci. 2013 5(3), 862-866

Pattnaik A, Sarkar R, Sharma A, Yadav KK, Kumar A, Roy P, Mazumder A, Karmakar S, Sen T. Pharmacological studies on Buchanania lanzan Spreng.- a focus on wound healing with particular reference to anti-biofilm properties. Asian Pac J Trop Biomed. 2013 Dec; 3(12):967-74. doi: 10.1016/S2221-1691(13)60187-2

Anti-biofilm activity of Marula – a study with the standardized bark extract J. Ethnopharmacol, 2014 (Under Revision).

Dr. Sanmoy Karmakar

a) Cardiovascular Toxicity:

* Baseline ECG study of Wister Rats (Male and Female) with final objective of QT

measurements and its respective Correction (QTc) depending on RR interaval (Heart Rate)

[Two widely used correction formulas are Fridericia’s cube root formula (QTc = QT/RR1/3) and

Bazett’s square root formula (QTc = QT/RR1/2) (Bazett 1920). Heart rate values are extremely

variable between different species, especially small rodents have a heart rate several times higher

than humans. For rats, Kmecova and Klimas (2010) adjusted Bazett’s equation [QTc= QT/

(RR/150) 1/2] with a normalization factor of 150ms.]

* Investigation of Arrthymogen (Drugs having arrthymogenic effects) on QTc in rats followed

by dose titration – inorder to establish Dose vs QTc interval and finding the dose which

corresponds to Normal to Near Normal QTc interval.

* Establishing Hypokalemia with subsequent assessment of Serum K+, Na+ & Cl- with Ion

selective electrodes.

* Under hypokalemic condition the same dose range of Arrthymogen (as in serial 2) will be

administered and subsequent QTc measurements will be taken to find the variation in QT.

* Studies will be done by supplementation of respective electrolytes (esp. K+) to understand the

reversal of QT interval.

* Specific IKr blockers (e.g. E-4031, Dofetilide) will be engaged to find out involvement of

rectifier K current channel in this study design in rats.

b) Toxicity study:

Formaldehyde contamination in fish is a well known fact. A majority of the studies have been done with sea fish, where it has been observed that the carp type of fishes have a negligible amount of free formaldehyde. However, some recent studies are of the opinion that even carp type of fishes can be contaminated with considerable amount of formaldehyde. Presently we have selected fish from both the carp and non-carp variety. The fish samples were purchased from the local market where the fishes from carp variety were fresh but dead, while that of the non-carp Variety were alive. Thereafter, the individual fish flesh were homogenized and finally the free formaldehyde was estimated as a stable derivative of the same against standard in HPLC in reverse phase.

9.9 Work plan during 2014-17

Dr. Kunal Roy

In silico modeling exercises will be used for the rational design of new analogues with Anti-alzheimer activity (acetylcholinesterase inhibitors, cyclin-dependant kinase 5/p25 inhibitors)

Antimalarial activity against P. falciparum (carbonic anhydrase inhibitors, calcium-dependent protein kinase 1 inhibitors)

Dr. Amalesh Samanta

Continued in vivo prebiotic studies of Gum odina on mice models:

Lymphocyte proliferation assay

Measurements of cytokines by using mouse specific ELISA Kit

Detailed in vitro study of gum odina as prebiotic on shimulator of human intestine microflora ecosystem (SHIME ) model.

Development of controlled release multiple emulsion formulations by using Gum odina as pharmaceutical excipient.

Prof. Tapan Kumar Maity

To synthesize & improve the yield of 2, 4 –diamino-5-furfuyl-pyrimidine.

Cyclocondensation reaction of 2, 4-diamino-5-furfuyl-pyrimidine by using Schiff and mannich base.

To characterize the newly synthesized compound by means of their IR,1HNMR, 13 CNMR &Mass spectroscopy.

To evaluate anti proliferative activity (in vitro &in vivo) of synthesized compound.

Dr. Pulok K Mukherjee

Screening of some Indian food plants for carbonic anhydrase inhibitory activity of some medicnal plants for their potential use as diuretic, glaucoma, hypertension etc.

Screening of some Indian food plants for acetyl cholinesterase inhibitory activity and assessment of their potential against Alzheimer’s disease.

Standardisation of these plants based on marker analysis

Safety evaluation through CYP 450 enzyme inhibition assay

Based on the activity potential of several plants activity of Rho kinase inhibition or lipase inhibition potential will be evaluated based on their traditional uses in future.

Prof. Biswanath Sa

Multi unit dosage form based on synthetic and natural polymers for modified release drug delivery have been investigated.

Currently, industrially feasible matrix tablet dosage forms using non toxic, biocompatible, biodegradable natural polymers far under investigation.

Dr.Tuhinadri Sen

a. Screening and standardization of mangrove flora for bioactive plant products effective against different gram+ve and gram –ve bacteria

b. The synergy of the novel antimicrobial agents with conventional antibiotics will be assessed on different pathogenic and non pathogenic strains and on biofilms (using uv-vis and fluroscense spectroscopy, RT-PCR

c. Effect of LPS induced cytokine production in peripheral blood mononuclear cells (PBMC) using Elisa and Flowcytometry

d. The study will also encompass assessment of the bioactive molecules against different models in vitro and in vivo models of sepsis.

e. Toxicity studies d. Formulation development and assessment on biomembranes

Dr. Sanmoy Karmakar

a) If the QT parameters in rats appears to be comparable with that of Beagle Dogs specially in

context to QT prolongation in response to known arrthymogen and altered serum electrolyte –

Then a model of study can be suggested for Cardio-safety using Rats (which is otherwise

notoriously debated for presence of Ikr).

b) In the event of findings as stated in serial (a) appears to acceptable – a new method may be

tried for Cardio-safety of Drugs / Herbal Drugs / Food Supplements which is otherwise

considered to be safe in conventional assessment where mild alteration in QT can not be

accounted. Whereas in a combination approach (Arrthymogen + Altered Serum Electolyte)

milder propensity to prolonge QT can be exerbated.

9.2. Chemical Engineering

Dr. Chiranjib Bhattacharjee, Chemical Engineering, Journal Publications: 91 (As per Scopus), Patent (filed): 4, H-index: 14, Total citations: 532 (As per Scopus), PhD Awarded: 15, PhD ongoing: 8, Awarded and ongoing Master’s thesis guidance: 28 (awarded) and 3 (continuing).

9.2.1. Special Achievements

i. Chaired a technical session on “Traditional Medicines and Globalization – The Future of Ancient Systems of Medicine” in the 12th International Congress of Ethnopharmacology (ISE 2012) organized by School of Natural Product Studies, Jadavpur University, Kolkata and held at Science City, Kolkata during February 17 – 19, 2012.

ii. Member of Selection Committee in connection with recruitment of ‘Scientist’ at CSIR-Central Glass and Ceramic Research Institute (CGCRI), Kolkata on August 6, 2013 (vide letter no. GC/R&A/GAP0341/SS/2013-14(15) dated July 18, 2013).

iii. Acted as Judge in the one-day workshop held at CSIR-CGCRI, Kolkata on Tuesday, August 20, 2013, observed as “Research Scholars Day Programme”.

iv. Acted as Session Chair in Technical Session – V (TS-V) at International Conference on “Membranes and Applications” (ICMA 2013) held at Central Glass and Ceramic Research Institute (CGCRI) during November 22-23, 2013.

v. Received “Sir Ganga Ram Memorial Prize” for best paper award in December 2013 from the Institution of Engineers (India). The award was given for best paper in the subject category for the paper as mentioned below: Arijit Nath, Shubhrajit Sarkar, Madhumita Maitra, Chiranjib Bhattacharjee, Ranjana Chowdhury, “An Experimental Study on Production of Intracellular b-Galactosidase at Different Conditions by Batch Process Using Isolated Bacillus safensis (JUCHE 1) and Characterization of Synthesized b-Galactosidase”, J. Inst. Eng. India Ser. E (Springer) (2013) DOI 10.1007/s40034-013-0011-z

9.2.2. Relevant Projects in Last 10years including the Ongoing Projects

Sl No.

Name of the

funding agency

Project title Year of fundin

g

Duration

(Years)

Amount Sanctioned

Rs. (in Lakhs)

Status

Completed/ Ongoing

1. AICTE Facilitated solute transport in ultrafiltration of fruit juice and milk whey using rotating disk

and cross flow membrane

2003 3 Rs.19.6 lakhs Completed

Received best

project

national award (first

prize) from AICTE

2. TEQIP Project on extraction of ‘pan’ oil and it’s by products from betel

leaf

2005 2 Rs. 5.5 lakhs Completed

3. Indo-Australian:

DBT/

DEST

Milk nutraceuticals: A biotechnology opportunity for Australian and Indian Dairy

Producers

2007 3 Rs. 54.2 lakhs (JU: 41.52 lakhs and

IITK: 12.68lakhs)

Completed

4. DST, Govt. of India

Development of Novel High Shear Membrane Module

(As Co-Investigator, PI: Dr. DebasishSarkar, Asst. Professor,

Chemical Engineering Dept., Calcutta University)

2009 3 Rs. 20.5606 Lakh

(Project is operational

in CU)

Ongoing

4. UGC

(Major Project)

Production and Purification of β-galactosidase from Milk Whey-based Lactic Acid

Bacteria using Fermentation and Membrane-based Separation

Techniques

2010 3 Rs. 9,79,800/- Continuing

5. CSIR – SUPRA project

Modeling studies on CO2 capture from natural gas using

gas-liquid contactor

2011 10 months

Rs. 3,70,000/- Completed (on

March31, 2012)

6. DST

(Indo-Korean)

Nano-material based membrane in water purification

2011 3 Rs. 23,92,560/-

Continuing

7. DST sponsored

New Indigo project

(Indo-EU project)

From Grey to Green: How to Improve the Sustainability of

Wastewater and Drinking Water

2012 2 Rs. 18,59,120/-

(JU: 15,34,160

TERI:

Continuing

Indian Collaborato

r: TERI

3,24,960)

8. AICTE (RPS

project)

Conversion of de-proteinated whey to ethanol

File no.:8023/RID/RPS-22/Pvt (II-Policy)/2011 – 2012

(As Co-Investigator, PI: Dr. Sangita Bhattacharjee, Asst.

Professor, Chemical Engineering Dept., Heritage

Institute of Technology, Kolkata)

2012 2 Rs. 13,67,000/-

Continuing

9.2.3. Relevant Publications in Last 5years

SL NO

Paper details

1. Sirsha Putatunda, Dwaipayan Sen, Ankur Sarkar, Ranjana Chowdhury, Debasish Sarkar and Chiranjib Bhattacharjee, “Two indigenous high sheared membrane modules'performance expatiation for the ultrafiltration of polyethylene glycol”, RSC Adv. (The Royal Society of Chemistry), 2014, 4, pp. 6435 – 6446 (DOI: DOI: 10.1039/c3ra44117b).

2. Bipasha Das, Sangita Bhattacharjee, Chiranjib Bhattacharjee, “Study on Conversion of Deproteinated Whey to Ethanol”, World Research Journal of Engineering & Technology, Volume 2, Article 1, 2013, [ISSN: 2278-8549]

3. Barnali Mondal, Ranjana Chowdhury, Chiranjib Bhattacharjee, “Optimization of pediocin production by batch fermentation of pediococcus acidilactici NCIM 2292 using goat meat processing waste”, Research Journal of Biotechnology, (2013) 8 (10) , pp. 19-25

4. K. Selvaraj, Ranjana Chowdhury, Chiranjib Bhattacharjee, “Isolation and structural elucidation of flavonoids from aquatic fern Azolla microphylla and evaluation of free radical scavenging activity”, International Journal of Pharmacy and Pharmaceutical Sciences, (2013) 5 (SUPPL 3), pp. 743-749

5. Dwaipayan Sen, Santanu Sarkar, Sangita Bhattacharjee, Sibdas Bandopadhya, Sourja Ghosh, and Chiranjib Bhattacharjee, “Simulation of the Effect of Various Operating Parameters for the Effective Separation of Carbon Dioxide into an Aqueous Caustic Soda Solution in a Packed Bed Using Lattice Boltzmann Simulation”, Ind. Eng. Chem. Res., 2013, 52 (4), pp 1731–1742 (ACS Journal) (DOI: 10.1021/ie301954c).

6. Arijit Nath, Chiranjib Bhattacharjee, Ranjana Chowdhury, “Synthesis and Separation of Galacto-oligosaccharides using Membrane Bioreactor”, Desalination (Elsevier Science

Publishers), 316 (2013) pp. 31-41 (DOI: 10.1016/j.desal.2013.01.024).

7. Saurav Bhattacharyya, Somenath Dutta, Siddhartha Datta and Chiranjib Bhattacharjee, “Improve the recovery of fermentable sugar from rice straw by sonication and its mathematical modeling”, J. Inst. Eng. India Ser. E (Springer), 93(1) (2013), Page 37-43 (2013) (DOI 10.1007/s40034-013-0007-8).

8. Sujaya Bandyopadhyay, Ranjana Chowdhury, Chiranjib Bhattacharjee, “Steady state performance of a bioreactor for production of Near Zero Sulfur Diesel (NZSD) and bio-surfactant”, Journal of Clean Energy Technologies (IACSIT Press, ISSN: 1793-821X), 1(3) (2013) pp. 189 – 193.

9. Arijit Nath, Sudip Chakraborty, Chiranjib Bhattacharjee, “Bioadsorbtion of industrial dyes from aqueous solution onto water hyacinth (Eichornia crassipes): equilibrium, kinetic, and sorption mechanism study”, Desalination & Water Treatment (Taylor & Francis), (2013) (doi: 10.1080/19443994.2013.787028).

10. Sujaya Bandyopadhyay, Ranjana chowdhury, Chiranjib Bhattacharjee, Supratim Pan, “Simultaneous production of biosurfactant and ULSD (Ultra low sulfur diesel) using Rhodococuus Sp in a Chemostat”, Fuel (Elsevier Science Publishers), 113 (2013) pp. 107 – 112 (DOI: http://dx.doi.org/10.1016/j.fuel.2013.05.036).

11. Lei Liu, Moon Son, Sudip Chakraborty, Chiranjib Bhattacharjee, Heechul Choi, “Fabrication of ultra-thin polyelectrolyte/carbon nanotube membrane by spray-assisted layer-by-layer technique: characterization and its anti-protein fouling properties for water treatment”, Desalination and Water Treatment (Taylor & Francis), (2013) (DOI:10.1080/19443994.2013.780767) 51 (31-33), pp. 6194-6200.

12. Debojyoti Chakraborty, Debasish Sarkar, Chiranjib Bhattacharjee, “Modeling and Simulation of Rotating Disk-Membrane module in ultrafiltration of Bovine Serum Albumin”, Separation Science & Technology (Taylor & Francis), (2013) 48 (17), pp. 2549-2566. (DOI:10.1080/01496395.2013.811691)

13. Arnab Baksi, Sirsha Putatunda, Dwaipayan Sen, Ankur Sarkar, Chiranjib Bhattacharjee, “Protocol Development for the Carbohydrate Quantification in Black Liquor with Brix Refractometer”, J. Inst. Eng. India Ser. E (Springer), (2013) DOI 10.1007/s40034-013-0012-y (in press).

14. Arijit Nath, Shubhrajit Sarkar, Madhumita Maitra, Chiranjib Bhattacharjee, Ranjana Chowdhury, “An Experimental Study on Production of Intracellular b-Galactosidase at Different Conditions by Batch Process Using Isolated Bacillus safensis (JUCHE 1) and Characterization of Synthesized b-Galactosidase”, J. Inst. Eng. India Ser. E (Springer) (2013) DOI 10.1007/s40034-013-0011-z (in press).

15. Arijit Nath, Sudip Chakrabarty, Shubhrajit Sarkar, Chiranjib Bhattacharjee, Enrico Drioli, Ranjana Chowdhury, “Purification and Characterization of β‑galactosidase Synthesized from Bacillus safensis (JUCHE 1)”, Ind. Eng. Chem. Res. (American Chemical Society) 52 (33) (2013), pp 11663–11672 (DOI: dx.doi.org/10.1021/ie4008584).

16. Dwaipayan Sen, Ankur Sarkar, Saikat Das, Ranjana Chowdhury, Chiranjib Bhattacharjee, “Batch Hydrolysis and Rotating Disc Membrane Bio Reactor for the Production of Galacto-oligosaccharides: A Comparative Study”, Ind. Eng. Chem. Res., 2012, 51 (32), pp 10671–10681 (ACS Journal)( DOI: 10.1021/ie3005786).

17. Saurav Bhattacharyya, Siddhartha Datta, Chiranjib Bhattacharjee, “Sonication boost the total reducing sugar (TRS) extraction from sugarcane bagasse after dilute acid hydrolysis”, Waste & Biomass Valorization (Springer) 3 (1) (2012) pp. 81-87 (DOI: 10.1007/s12649-011-9078-2).

18. Ranjana Das, Amrita Dutta, Chiranjib Bhattacharjee, “Preparation of sesame peptide and evaluation of antibacterial activity on typical pathogens”, Food Chemistry (Elsevier Science) 131 (2012) pp. 1504–1509 (doi:10.1016/j.foodchem.2011.09.136).

19. Ankur Sarkar, Debasish Sarkar, Chiranjib Bhattacharjee, “Design and performance characterization of a new shear enhanced module with inbuilt cleaning arrangement”, J. Chem. Tech. & Biotech. (Wiley) (in press) (DOI 10.1002/jctb.3728).

20. Arunava Choudhury, Siddhartha Sengupta, Chiranjib Bhattacharjee, Siddhartha Datta, “Effects of Co-solutes on Cr (VI) removal by Micellar Enhanced Ultrafiltration (MEUF) Process”, Desalination & Water Treatment (Taylor & Francis), 44 (2012) 67 – 74.

21. Ranjana Das, Santinath Ghosh and Chiranjib Bhattacharjee, “Enzyme Membrane Reactor in Isolation of Antioxidative Peptides from Oil Industry Waste: A Comparison with Nonpeptidic Antioxidants”, LWT – Food Science and Technology (Elsevier Science Publishers) 47 (2012) pp. 238 – 245 (DOI information: 10.1016/j.lwt.2012.01.011).

22. Debasish Sarkar, Shirshendu Bardhan, Amitava Bandyopadhyay, Monojit Chakraborty, Chiranjib Bhattacharjee, “Simulation of Continuous Stirred Ultrafiltration process: an approach based on Surface Renewal Theory”, Asia Pacific J. Chem. Eng., (Elsevier Science Publishers) 7(2) (2012) pp. 279 – 294 (DOI: 10.1002/apj.534).

23. Ankur Sarkar, Siddhartha Moulik, Debasish Sarkar, Anirban Roy, Chiranjib Bhattacharjee, “Performance characterization and CFD analysis of a novel shear enhanced membrane module in ultrafiltration of Bovine Serum Albumin (BSA)”, Desalination (Elsevier Science) 292 (2012) pp. 53 – 63 (10.1016/j.desal.2012.02.009).

24. Ankur Sarkar, Siddhartha Moulik, Debasish Sarkar, Anirban Roy, Chiranjib Bhattacharjee, “Performance characterization and design evaluation of Spinning Basket Membrane (SBM) module using computational fluid dynamics (CFD)”, Sep. Purif. Tech. (Elsevier Science Publishers), 94 (2012) 23-33.

25. Jaya Sikder, Sudip Chakraborty, Parimal Pal, Enrico Drioli, Chiranjib Bhattacharjee, “Purification of lactic acid from microfiltrate fermentation broth by cross-flow nanofiltration”, Biochemical Engineering Journal (Elsevier Science Publishers), 69 (2012) pp. 130 – 137 (DOI information: 10.1016/j.bej.2012.09.003).

26. Saurav Bhattacharyya, Sudip Chakraborty, Enrico Drioli, Chiranjib Bhattacharjee, “Production of total reducing sugar (TRS) from acid hydrolyzed potato peels by sonication and its optimization”, Environmental Technology (Taylor & Francis), (in press) (DOI: 10.1080/09593330.2012.733965).

27. Ankur Sarkar, Debasish Sarkar, Madhurima Gupta, Chiranjib Bhattacharjee, “Recovery of Polyvinyl Alcohol from Desizing Wastewater Using a Novel High-Shear Ultrafiltration Module”, Clean – Soil, Air, Water (WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim), 40 (8) (2012) , 830–837.

28. S. Dutta, P. Sarkar, Chiranjib Bhattacharjee, Siddhartha Datta, “Performance comparison of rotating disk ultrafiltration membrane module, a high shear device with cross flow module”, Int. J. Environment & Pollution (Inderscience Enterprise Ltd), 49 (3-4) (2012), 197 – 209.

29. Ranjana Das, Chiranjib Bhattacharjee, and Santinath Ghosh, “Novel Approach to Recover Natural Antioxidants from Oil Seed Meal in Ultrafiltration-Nanofiltration-Based Technique”, Ind. Eng. Chem. Res., 2011, 50 (21), pp 12124–12133 (ACS Journal) (DOI: 10.1021/ie200485a).

30. Kumar Anupam, Suman Dutta, Chiranjib Bhattacharjee, Siddhartha Datta, “Optimization of Adsorption Efficiency for Reactive Red 198 Removal from Wastewater over TiO2 Using Response Surface Methodology”, The Canadian J. Chem. Eng. (John Wiley) 89 (2011) 1274- 1280. (DOI: 10.1002/cjce.20451).

31. Debasish Sarkar, Ankur Sarkar, Monojit Chakraborty, Soumyajit Sen, Chiranjib Bhattacharjee, “Transient solute adsorption incorporated modeling and simulation of unstirred dead-end ultrafiltration of macromolecules: an approach based on self-consistent field theory”, Desalination (Elsevier Science Publishers) (doi:10.1016/j.desal.2010.11.020) 273 (2011), pp. 155-167

32. Dwaipayan Sen, Anirban Roy, Apratim Bhattacharya, Debadrito Banerjee, Chiranjib Bhattacharjee, “Development of a knowledge based hybrid neural network (KBHNN) for studying the effect of diafiltration during ultrafiltration of whey”, Desalination (Elsevier Science Publishers) (doi:10.1016/j.desal.2010.10.038) 273 (2011), pp. 168-178.

33. Ranjana Das, Dwaipayan Sen, Ankur Sarkar, Saurav Bhattacharyya, Chiranjib Bhattacharjee, “A Comparative Study on the Production of Galacto-oligosaccharide (GOS) from Whey Permeate in Recycle Membrane Reactor and in Enzymatic Batch Reactor”, Ind. Eng. Chem. Res. (ACS Journal), 50 (2) (2011) pp. 806–816.

34. Debasish Sarkar, Diptendu Datta, Dwaipayan Sen, Chiranjib Bhattacharjee, “Simulation of Continuous Stirred Rotating Disk-Membrane Module: An Approach Based on Surface Renewal Theory”, Chem. Eng. Sci. (Elsevier Science Publishers), 66 (2011) 2554 – 2567 (doi:10.1016/j.ces.2011.02.056).

35. Dwaipayan Sen, Aaron Gosling, Geoff W. Stevens, P.K. Bhattacharya, Andrew R. Barber, Sandra E. Kentish, Chiranjib Bhattacharjee, Sally L. Gras, “Galactosyl oligosaccharide purification by ethanol precipitation”, Food Chemistry (Elsevier Science Publishers), 128 (2011) pp. 773 – 777 (doi:10.1016/j.foodchem.2011.03.076).

36. Dwaipayan Sen, Ankur Sarkar, Aaron Gosling, Sally L. Gras, Geoff W. Stevens, Sandra E. Kentish, P. K. Bhattacharya, Andrew R. Barber, Chiranjib Bhattacharjee, “Feasibility study of enzyme immobilization on polymeric membrane: A case study with enzymatically Galacto-oligosaccharides production from lactose”, J. Membr. Sci. (Elsevier Science Publishers), 378 (2011) pp. 471-478 (doi:10.1016/j.memsci.2011.05.032).

37. Arunava Chowdhury, Siddhartha Sengupta, Chiranjib Bhattacharjee, Siddhartha Datta, “Extraction of Hexavalent Chromium from Aqueous Stream by Emulsion Liquid Membrane”, Separation Science & Technology (Taylor & Francis), 45 (2010) pp. 178 – 185

38. Suman Dutta, S.A. Parsons, Chiranjib Bhattacharjee, Siddhartha Datta, Sibdas Bandyopadhyay, Peter Jarvis, “Studies on Adsorption and Decolorization of Reactive Dye on TiO2 Surface”, Int. J. Environmental Engineering (IJEE) (InderScience Publishers), 2 (2010) 202 – 211.

39. Dwaipayan Sen, Wren Roy, Lipika Das, Sangeeta Sadhu, Chiranjib Bhattacharjee, “Ultrafiltration of macromolecules using rotating disc membrane module (RDMM) equipped

with vanes: Effects of turbulence promoter”, J. Membrane Science, (Elsevier Science Publishers) 360 (1-2) (2010) pp. 40 – 47.

40. Debasish Sarkar, Apratim Bhattacharya, Chiranjib Bhattacharjee, “Modeling the performance of a standard single stirred ultrafiltration cell using variable velocity back transport flux”, Desalination (Elsevier Science Publishers) 261 (1-2) (2010) pp. 89 – 98.

41. Suman Dutta, S.A. Parsons, Chiranjib Bhattacharjee, Sibdas Bandyopadhyay, Siddhartha Datta, “Development of an artificial neural network model for adsorption and photocatalysis of reactive dye on TiO2 surface”, Expert Systems with Applications (Elsevier Science Publishers) 37 (2010) pp. 8634 – 8638.

9.2.4. Relevant Patents and Policy Documents in Last 5years

1. Dwaipayan Sen, Chiranjib Bhattacharjee: A Bio-Reactor suitable for Enzymatic Reaction and method of carrying out Enzymatic Bio-Reaction, Application No. 1022/KOL/2010A, International Classification Number: C02F11/00, A61K9/00 2. Arijit Nath, Ranjana Chowdhury, Chiranjib Bhattacharjee: Consortium of bacterium B. Safensis (JUCHE1) isolated from casein whey, its process of isolation and its industrial applications thereof, Application No. 755/KOL/2011, dated 06.06.2011.

3. Debasish Sarkar, Chiranjib Bhattacharjee, Ankur Sarkar: A shear enhanced membrane module with inbuilt self cleaning mechanism, Application No. 845/KOL/2012 dated 27-07-2012.

4. Ranjana Das, Chiranjib Bhattacharjee: A process for manufacture of sesame seed based bioactive peptides, Application No. 899/KOL/2013 dated 29-07-2013.

9.2.5. Facilities Available

HPLC, year of installation: 2008, procured under MHRD sponsored “Bioprocess Engineering” program

UV-visible spectrophotometer, year of installation: 2008,

9.2.6. Ongoing Work under UPE II – 2012-14

Abstract

Ultrafiltration (UF) is primarily a size-exclusion-based pressure-driven membrane separation strategy, accepted, and well practiced processing operation in the dairy industry for whey treatment. Depending on molecular weight of target molecules, UF membranes of specific molecular weight cut-off (MWCO) have been chosen for separation process. During UF, high molecular weight component, such as protein, and suspended solids are rejected, while low molecular weight components like mono-saccharides, di-saccharides, salts, amino acids, organic, and inorganic acids pass through the membrane freely. Being a pressure-driven membrane separation process, pressure is applied over the UF membrane, which will facilitate permeation of low molecular weight solute through membrane. One of the major problems of UF technique

is the declination of permeate flux with time, which results mostly from deposition of rejected solute over membrane, known as concentration polarization, often leads to membrane fouling. In fact, fouling plays an important role in whey proteins separation by UF. Compared to conventional processes, the use of diafiltration (DF) offers several advantages, including high product purity, elimination of filter aids, and wetting agents. In the batch mode the different stages of DF are carried out in consecutive manner. After the pre-concentration of the batch, DF liquid is added into the batch tank, and UF continues until the desired concentration of low molecular weight solute molecule in the permeate is reached.

In the present investigation, different fractions of individual whey proteins (immunoglobulins, lactoferrin, lactoperoxidase, bovin serum albumin, α-lactalbumin, β-lactoglobulin), and lactose have been purified by cascade of different MWCO cross flow membrane module (100 kg.mol-1 to 5 kg.mol-1). Hydrodynamic studies were conducted under different TMPs (0.686 bar to 2.942 bar) at constant VCF. It was found that for all cases permeate flux increased with TMP 0.686 bar to 2.06 bar (later considered as optimum TMP), and with subsequent increase of TMP up to 2.942 bar, it remained virtually unchanged, possibly due to fully developed concentration polarization layer on membrane surface. High TMPs (2.06 bar to 2.942 bar) on the membrane surface provides higher cross-flow velocities, resulting in more turbulence, leading to reduction in concentration polarization, and hence higher flux. Further, use of MBR is a potential option for GOS synthesis and separation. Maximum β-galactosidase loading on the membrane surface in the multilayer form was 85% at optimum pH, when the ratio of PEI to β-galactosidase was 1:25. The optimum pH for PEI-enzyme aggregation was found 8.2 and for cross-linking it was 7. Stable immobilization was achieved over broad temperature range (4 °C to 65 °C). Permeate flux was found to increase with the increase of TMP, stirring speed and feed flow-rate of MBR. On the other hand, high initial substrate concentration has a negative influence on permeate flux, and it decreases with the increase of reaction temperature and above 45 °C i.e, 60°C the permeate flux increases sharply. The proposed process train could be used for fractionation of different whey proteins and recovery of lactose from whey with high purity and substantially good yield. Further, the proposed process may be extended to possible industrial application with suitable scale-up strategy.

9.2.7. Work plan during 2014-17

Implementation of zero effluent concepts with regard to different industries, like Dairy, Pulp & paper, Tannery, etc.

Bioremediation of soil with an objective to remove heavy metal and pesticide contamination. Reduction of heavy metal contamination in aquatic streams using biosorption and bio-

assimilation. Production of bioethanol from different effluent streams, agricultural residue and kitchen

waste. Photo-catalytic treatment of different wastewater

9.3. Department of Chemistry, Organic Chemistry Section

9.3.1. Contributing Faculty member Dr. Saubhk Haldar, Department of Chemistry, Organic Chemistry Section, Jadavpur University, Age: 45, Journal Publications – 7, Conference Publications –1, Patents – Nil, Policy Documents – Nil, H Index – 5 (last 5 yrs), Cumulative Impact Factor –4.07, Total Citations – 74, Awarded and ongoing doctoral thesis guidance – 1 Ph.D, 2 (ongoing), Awarded and ongoing Master’s thesis guidance – 5 (Awarded) 3 (ongoing).

Dr. ASOK KUMAR MALLIK, Department: CHEMISTRY Age: 61 years. Journal Publications (last 5 years): 23 Conference Publications: 9 9.3.2. Special achievements: a) Council Member, Indian Chemical Society b) Associate Editor, Organic Chemistry & Biochemistry Section, Indian Chemical Society c) Scientist-in-charge, Organic Chemistry Section, Annual Convention of Chemists, Indian Chemical Society d) External Member, Departmental Research Committee, University of Kalyani e) External Member, Departmental Research Committee, University of Calcutta

9.3.4. Relevant Projects in Last 10years including the Ongoing Projects

Dr. Saubhik Haldar

Project Title Sponsoring Agency

Members Grant Value(Rs in Lakh)

Duration

Development of tissue engineering matrix from nano-structured lyotropic self assembly of peptide amphiphiles

DST Dr Saubhik Haldar (PI)

38 lacs 2009 –2012

9.3.5. Relevant Publications in Last 5years

Dr. Saubhik Haldar

Sl. Paper details 1 Generation of Bioactive Materials with Rapid Self‐Assembling Resorcinarene‐Peptides,

Mirren Charnley, Kathryn Fairfull‐Smith, Saubhik Haldar, Richard Elliott, Sally L McArthur, Nicholas H Williams, John W Haycock, Advanced Materials 21(28)(2009) 2909-2915;

2 Effect of peptide architecture on the self-assembly properties of tripeptide based anionic surfactants issued from two different peptide sequences: Ala-Ala-Val and Ala-Pro-Val in aqueous media (pH 7.4) S.K. Maji, S. Haldar Colloids and Surfaces A: Physicochemical and Engineering Aspects 414 (2012) 422–432. (Impact Factor 2.333).

3 Utilization of vinasse for the production of polyhydroxybutyrate by Haloarcula marismortui, Arnab Pramanik, Anindita Mitra, Meyyappan Arumugam, Anirban Bhattacharyya, Sohini Sadhukhan, Atrayee Ray, Saubhik Haldar, Ujjal Kumar Mukhopadhyay, Joydeep Mukherjee, Folia microbiologica 57(1) (2012) 71-79.

4 Role of non-covalent interactions in the molecular organization of N-n-hexadecanoyl amino acid amphiphiles with hydrophobic Cα-side chains in Tris buffer (pH 9.3) Saubhik Haldar, Sudipta K Maji, Colloids and Surfaces A: Physicochemical and Engineering Aspects 420 (2013) 10–21.

5 Spontaneous physical gelation from functionally modified tripeptides [C16-Ser(OBz)-X-Ser(OBz)-C16] via supramolecularly assisted polarophobic association in diverse organic media, Saubhik Haldar, Sudipta K Maji, Colloids and Surfaces A: Physicochemical and Engineering Aspects 430 (2013) 65–75.

6 Enhanced Biotransformation of Fluoranthene by Intertidally Derived Cunninghamella elegans under Biofilm-Based and Niche-Mimicking Conditions, S Mitra, A Pramanik, S Banerjee, S Haldar, R Gachhui, J Mukherjee, Applied and environmental microbiology 79(24) (2013) 7922-7930.

7 Production of poly-3-(hydroxybutyrate-co-hydroxyvalerate) by Haloferax mediterranei using rice-based ethanol stillage with simultaneous recovery and re-use of medium salts; A. Bhattacharyya, J Saha, S Haldar, A Bhowmic, UK Mukhopadhyay, J. Mukherjee Extremophiles (2014) pp. 1-8

Prof. Asok K. Mallik

1. “Facile conversion of para-benzoquinones to para-alkoxyphenols with primary/secondary alcohols and amberlyst-15: a process showing novel reducing property of such alcohols”, Rina Mondal, Chayan Guha, and A. K. Mallik, Tetrahedron Lett. 2014, 55, 86–89.

2. “An Efficient and Green Method for Synthesis of 2,4,5-Triarylimidazoles without Use of Any Solvent, Catalyst, or Solid Surface”, S. Samanta, S.Sarkar, R. Pal, and A. K. Mallik, Organic Chemistry International, 2013, 2013, Article ID 512074, 5 pages

3. “A Rapid, Efficient and Green Method for Synthesis of 3,3'-Arylmethylene-bis-4-hydroxycoumarin without Use of any Solvent, Catalyst or Solid Surface” A. Das Gupta, S. Samanta, R. Mondal and A. K. Mallik, Chem. Sci. Trans., 2013, 2(2), 524-528.

4. “Efficient and rapid solvent-free synthesis of 1,8-dioxo-octahydroxanthenes and 2,2'-(phenylmethylene)bis(3-hydroxy-5,5-dimethyl-cyclohex-2-en-1-ones) under microwave irradiation condition”, S. Samanta, A. Das Gupta, Rina Mondal and A. K. Mallik, J. Indian Chem. Soc., 2013, 90, 845-852.

5. “A simple synthesis of E-9-aryl-5-arylidene-1-oxo-1,2,3,4,5,6,7,8-octahydroxanthenes and their lower analogues from E,E-α,α′-diarylidenecycloalkanones”, S. Samanta, A. Das Gupta, Rina Mondal and A. K. Mallik, J. Chem. Sci., 2013, 125, 737-743.

6. “Schmidt Reaction of E-3-Benzylidenechromanones and E-3-Benzylidenethiochromanones”, Tapas K. Mandal, Rammohan Pal, Rina Mondal, Sankar P. Dey and A. K. Mallik, Journal of Chemistry, 2013, Vol. 2013, Article ID 392128, 5 pages.

7. “Two expedient ‘one-pot’ methods for synthesisof β-aryl-β-mercaptoketones over anhydrous potassium carbonate or amberlyst-15 catalyst”, Chayan Guha, Rina Mondal, Rammohan Pal and A. K. Mallik, J. Chem. Sci. 125, 2013, 1463–1470.

8 . A convenient, eco-friendly and efficient method for synthesis of bis(3-indolyl)methanes “on-water”, A. K. Mallik, R. Pal, C. Guha and H. Mallik, Green Chem. Lett. Rev., 2012, 5, 321-327.

9. An Expeditious Synthesis of cis-2-(Aroylmethyl)-4-phenylthiochromans by Iodine Catalyzed Combination of Thiophenol with Cinnamylideneacetophenones; A. K. Mallik, T. K. Mandal, R. Pal, D. Ghosal and A. Patra, Synlett, 2012, 23, 2459-2462.

10. An efficient and highly diastereoselective synthesis of cis-2,4-diarylthiochromans; C. Guha, R. Pal and A. K. Mallik, Arkivoc, 2012, (ix), 85-94.

11. Simple Synthesis of a New Family of 22- to 28-Membered Macrocycles Containing Two Chalcone Moieties; R. Mondal, T. K. Mandal, A. K. Mallik, Arkivoc, 2012, (ix), 95-110.

12. A Convenient, Eco-friendly, and Efficient Method for Synthesis of 3,3'-Arylmethylene-bis-4-hydroxycoumarins “On-water”; A. Das Gupta, S. Samanta, R. Mondal and A. K. Mallik, Bull Korean Chem Soc., 2012, 33, 4239-4244.

13. Facile Iodine-catalyzed Michael Addition of Indoles to α,α′-Bis(arylmethylene)cyclo- pentanones: An Efficient Synthesis of E-2-(3-Indolylphenylmethyl)-5-phenylmethylene-cyclopentanones; R. Pal, A. Das Gupta and A. K. Mallik, ISRN Organic Chemistry, 2012, Volume 2012, Article ID 674629, 6 pages, doi:10.5402/2012/674629.

14. An Expeditious and Safe Synthesis of Some Exocyclic α,β-Unsaturated Ketones by Microwave Assisted Condensation of Cyclic Ketones with Aromatic Aldehydes over Anhydrous Potassium Carbonate; R. Mondal, T. K. Mandal and A. K. Mallik*, Organic Chemistry International, 2012, Volume 2012, Article ID 456097, 8 pages, doi:10.1155/2012/456097.

15. Synthesis of flavanones by use of anhydrous potassium carbonate as an inexpensive, safe and efficient basic catalyst, Rina Mondal, Arpita Das Gupta and Asok K. Mallik, Tetrahedron Lett., 2011, 52, 5020-5024.

16. NBS Oxidation of E-3-Benzylidenechromanones to 3-(α-Hydroxybenzyl)-chromones and 3-Benzoylchromones, Tapas K. Mandal, Rammohan Pal, Rina Mondal, Sankar P. Dey and Asok K. Mallik, Org. Prep. Proc. Int., 2011, 43, 467-474.

17. trans-2-Phenyl-4-thiophenoxy-3,4-dihydro-2H-1-benzothiopyran, Asok. K. Mallik, Tapas. K. Mandal, Rammohan. Pal and Amerendra. Patra, Molbank, 2011, 1, M719.

18.Formation of organo-mercuro compounds by mercuric acetate oxidation of 2′-allyoxy-5′-chloroacetophenone oxime and 2′-allyloxy-5′-chloroacetophenone, Sankar P. Dey and Asok K. Mallik, J. Indian Chem. Soc., 2011, 88, 437-441.

19. Iodine-catalysed conjugate addition of indole with α-cinnamylideneketones: Formation of β-(3-indolyl)-α,β-dihydro-α-cinnamylideneketones and bis(3-indolyl)methylbenzene, Rammohan. Pal, Tapas K. Mandal and Asok. K. Mallik, Indian J. Chem., 2011, 50B, 619-623.

20. Facile condensation of aromatic aldehydes with chroman-4-ones and 1-thiochroman-4-ones catalysed by amberlyst-15 under microwave irradiation condition; Tapas K. Mandal, Rammohan Pal, Rina Mondal and Asok K. Mallik, E-J. Chem., 2011, 8, 863-869.

21. Amberlyst-15 catalysed microwave assisted cross-aldol condensation between ketones and aldehydes under solvent free condition; Rammohan Pal, Tapas K. Mandal, Chayan Guha and Asok. K. Mallik, J. Indian Chem. Soc., 2011, 88, 711-717

22. An efficient synthesis of E-2-amino-4-aryl-8-(arylmethylene)-5,6,7,8-tetrahydrobenzo[d]pyrimidines anf their lower analogues, Rammohan Pal, Tapas K. Mandal, Swati Samanta and Asok K Mallik, J. Indian Chem. Soc., 2010, 87, 711-715.

23. Base-catalysed cyclocondensation of α,α′-bis(arylmethylene)cyclohexanones with thiourea: Formation of E-8-(arylmethylene)-4-aryl-1,2,3,4,5,6,7,8-octahydrobenzo[d]pyrimidine-2-thiones, Rammohan Pal, Tapas K. Mandal and Asok K. Mallik, J. Indian Chem. Soc., 2009, 86, 402-405.

9.3.6 Facilities Available

a)NMR, IR, UV-Vis, Time resolved Fluorescence, Circular Dichroism and DSC (Department of Chemistry, JU)

b) Bruker AV-300 (300 MHz) NMR spectrometer – purchased with grant from DST-FIST proggramme

c) Waters HRMS instrument [Xevo G2QTof] spectrometer – purchased with grant from DST, Govt. of India, in the International year of Chemistry

d) Single Crystal X-ray (Bruker SMART) diffractometer– purchased with grant from DST-FIST programmed

9.3.7 Ongoing Work under UPE II – 2012-14

Dr. Saubhik Haldar

1. Title: Synthesis and physicochemical charactrizeation of amino acid derived nanosttructured self assembled bioorganic soft material as a potent drug delivery system. Saubhik Haldar and Koninika Karmakar (Synthesis is completed, physical studies are going on)

2. Synthesis of tripeptide based amphiphilic systems rendering remarkable physical gelation properties in aqueous media in ambient pH of 7.4. Saubhik Haldar and Koninika Karmakar (Experiments on progress)

3. Generation of nanostructured organogels issued from amino acid derived chiral molecular units

Asok Kumar Mallik

Synthesis of Biologically Important Nitrogen and Oxygen heterocycles 1. Compounds containing imidazole moiety show a range of pharmacological properties and play important roles in biochemical processes. Various substituted imidazoles act as inhibitors of P38 MAP kinase and B-Raf kinase, glucagon receptors and antitumor, anti-inflammatory, and antithrombotic agents. An efficient and green method for synthesis of 2,4,5-triarylimidazoles without use of any catalyst or solvent has been developed simply by heating (at 130 0C) of mixtures of 1,2-diketone, aromatic aldehyde, and ammonium acetate in 1 : 1 : 3 mole ratio.

2. Chalcone derivatives occur in the plant kingdom and they are known to possess interesting biological activities such as anticarcinogenic, anti-inflammatory, antioxidant, antimicrobial, anti-allergic,and antimalarial properties. In the present study several oxygen containing macrocycles incorporating more than one chalcone moieties have been synthesized.

9.3.8. Work plan during 2014-17

Dr. Saubhik Haldar

Physicochemical studies will be completed for the newly synthesized systems Synthesized materials will be exploited for a collaborative research endeavor to use them as

drug delivery system. Novel synthetic methods will be developed to reduce synthetic complexity. 2nd generation of amphiphilic systems will be synthesized based on the obtained results.

Asok Kumar Mallik

Development of new and environment-friendly synthetic routes to condensed nitrogen heterocycles like quinolines, benzimidazoles, benzopyrans etc.

Synthesis of oxygen containing macrocyclic compounds possessinng biologically important moieties like chalcone, pyridine, indole etc.

Transformation of biologically important heterocycles like quinolines, indoles, benzopyrans, benzothiopyrans etc.

Chemical investigation of several medicinal plants of North-east India in search of new biologically active compounds.

[It may be mentioned here that the heterocyclic units present in some of the synthetic targets constitute important parts of biologically active natural compounds.]

9.4. Department of Food Technology & Biochemical Engineering

9.4.1. Contributing faculty member

Prof. Utpal Raychaudhuri, Department of Food Technology and Biochemical Engineering, Age: 59 years, Journal publications: 60, Conference publications: 20, Patents: 5, Awarded and ongoing doctoral thesis guidance – 33, Awarded and ongoing Masters thesis guidance – 45.

9.4.2. Special Achievements

1) Member of UGC Expert Committee to review performance of the Deemed University of National Institute of Food Technology Enterpreneurship and Management, Kundli, Haryana

2) 2. UGC Centre of Advanced Studies : Coordinator 3) 3. Centre for Medicinal Food and Applied Nutrition : Coordinator 4) 4. Government of India: President nominee for selection of Faculties of Tejpur Central

Government University, Assam 5) 4. Government of India: President nominee in the Faculty Council of Tripura University 6) 5. Member of Board of Directors of West Bengal State Food Processing and Horticultuture

Development Corporation Limited 7) 6. Task Force member and expert authority of Mid Day Meal Quality inspection, School of

Education Department, Government of West Bengal 8) 7. Indian Institute of Chemical Engineers Award for the year 2008:Sisir Kumar Mitra

Memorial Award for the Second Best Technical Paper published in the Institute journal on the topic “ Development of Do Probe Based Cholesterol Biosensor for the Determination of Free cholesterol in Food Samples”(Prof. Runu Chakraborty, Prof. Utpal Raychaudhuri, Prof. Parimal Chattopadhyay and Dr. Anjan Basu).Awarded in CHEMCON 2008, at Chandigarh.

9) Indian Institute of Chemical Engineers NRC Award 3rd Best Paper in Indian Chemical Engineer-2007 (Prof. Runu Chakraborty, Prof. Utpal Raychaudhuri, Prof. Parimal Chattopadhyay and Dr. Anjan Basu).Awarded in CHEMCON 2008, at Chandigarh.

9.4.3 Relevant Projects in Last 10years including the Ongoing Projects

Project Title Sponsoring

Agency Members

Grant Value

(Rs in Lakh) Duration

UGC CAS I Project

UGC

Prof. Utpal Raychaudhuri (PI)Prof. Runu Chakraborty

70

2007-2012

UGC CAS II Project

UGC

Prof. Utpal Raychaudhuri Prof. Runu Chakraborty

118

2013-2017

HRD Project on Bakery and Confectionery

Ministry of Food Processing, Government of India

Prof. Utpal Raychaudhuri

Prof. Runu Chakraborty

49.5

2004-2008

Natural Vinegar from palm juice

Department of Food Processing Industries, Government of West Bengal

Prof. Utpal Raychaudhuri Prof. Runu Chakraborty

20

2008-2013

Mechanisation of sweet meat processing unit

Department of Food Processing Industries, Government of West Bengal

Prof. Utpal Raychaudhuri Prof. Runu Chakraborty

12 2004-2007

Survey on Mid Day Meal quality for school of West Bengal

Education Department

Prof. Utpal Raychaudhuri

10 2009-2014

9.4.4 Relevant Publications in Last 5years

Books 1. Utpal Raychaudhuri & Uttam Raychaudhuri-----Fundamentals of Automatic Process Control, International Text Book, Taylor & Francis , USA, CRC Press, (2012)

2.. Arpita Das, Utpal Raychaudhuri, & Runu Chakraborty------- Book Chapter on Nutrceuticals Derived from Plant Sources ( Herbal) in Nutraceuticals & Functional Foods: Natural Remedy. (Ed) Brar SK, S. Kaur, Dhillon GS. Nova Science Inc. USA. Accepted for Publication. (2013)

Publications

Sl. Paper details 1 Antioxidant activity of natural plant sources in dairy dessert ( Sandesh ) under thermal

treatment, Bandyopadhyay, Mahuya; Chakraborty, Runu; Raychaudhuri, Utpal. LWT - Food Science and Technology vol. 41 No. 5 , 2008, pp. 816-825, Elseveir.

2 Effect of beet and honey on quality improvement and carotene retention in acarrot fortified milk product., Bandyopadhyay, Mahuya; Chakraborty, Runu; Raychaudhuri, Utpal. Innovative Food Science and Emerging Technologies vol. 9 , No. 1, 2008, p p. 9-17, Elsevier.

3 Effect of carrot on quality improvement of sweet syrupy cheese ball (Rasgulla) Bandyopadhyay, Mahuya; Chakraborty, Runu; Raychaudhuri, Utpal. International Journal of Dairy Technology, Vol 61, No. 3 , 2008, pp 290–299, Publisher : Wiley

4 Study on B-galactosidase enzymatic activity of herbal yogurt-----Banani Roy Chowdhury, Runu Chakraborty, and Utpal Raychaudhuri, International Journal of Food Science and Nutrition, Vol 59, No.2, 2008, pp 116-122, John Willey

5 Bromelain induces cardioprotection against ischemiareperfusion injury through Akt/FOXO pathway in rat myocardium, Bela Juhasz, Mahesh Thirunavukkarasu, Rima Pant, Lijun Zhan, Suresh Varma Penumathsa, Eric R. Secor Jr., Sapna Srivastava, Utpal Raychaudhuri, Venugopal P.Menon, Hajime Otani, Roger S. Thrall, and Nilanjana Maulik, Am J Physiol Heart Circ Physiol. 2008 ; 294(3): H1365–H1370, NIH Publication.

6 Comparison of the protective effects of steamed and cooked broccolis on ischaemia–reperfusion-induced cardiac injury, Subhendu Mukherjeea, Istvan Lekli, Diptarka Ray, Hiranmoy Gangopadhyay, Utpal Raychaudhuri and Dipak K. Das, British Journal of Nutrition Molecular Nutrition ,Vol 103 , ( 6 ), 2010, pp 815-823 , Cambridge Journals

7 The Effect of Turmeric, Lime, and Lemon on the Color and Rheological Characteristics of Tomato Puree. Ray Chowdhury Banani, Dutta Chaitali, Chakraborty Runu, Das Lipi, Mukhopadhyay Rabi Shankar, Raychaudhuri Utpal. Journal of Culinary Science & Technology, 7(4): , 2010, pp219 — 238. Publisher: Taylor and Francis

8 Effect of storage of surimi from the fish croaker on the organoleptic quality of surimi-based products-----Nityananda Das, B.K. Khuntia, and U. Raychaudhuri, International Journal of Processing and Post Harvest Technology, Vol . 1 , ( 2 ), pp. 51-55, 2010, Publisher : Hind Agricultural Research and Training Institute ,MUZAFFARNAGAR-251 001 (U.P.) INDIA

9 Role of phytochemicals in cell signalling. Bardhan Jayeeta, Chakraborty Runu, Raychaudhuri Utpal, Biochemistry: An Indian Journal. Publisher---Trade-Science-Inc,2010 http://tradescienceinc.com/index.php?option=com_content&view=article&id=3213:vol-4-issue-2-2010-11&catid=354:vol-4-issue-2&Itemid=451

10 Modulation of Palm Wine Fermentation by the control of Carbon and Nitrogen source on metabolism of Saccharomyces cerevisiae. Ghosh Satyabrata, Chakraborty Runu, Raychaudhuri Utpal, Journal of Food Technology, Vol 8, pp204-210, 2010, Publisher: Medwell.

11 Thermal And Microstructural Analysis of Rice (Oryzasativa L) and Lali (Metapenaeopsis stridulans) Extrusion, Hom Choudhury Mahuya , Chakraborty Runu, Sarkar Sreekanta , Raychaudhuri Utpal,Department , - Indian Journal of Animal Health,49(1) 2010, pp 1-10,Publisher : West Bengal Veterinary Association, India

12 Tocotrienols confer resistance to ischemia in hyper –cholesterolemic hearts: insight with genomics -------Somak Das ,Subhendu Mukherjee ,Istvan Lekli, Narasimman Gurusamy,

Jayeeta Bardhan ,Utpal Raychoudhury , Runu Chakravarty ,Sandip Banerji , Anne A. Knowlton , Dipak K. Das, Mol Cell Biochem ,DOI 10.1007/s11010-011-1041-9 (2011),Springer

13 The 21st Century Form of Vitamin E – Tocotrienol,Bardhan, Jayeeta, Chakraborty Runu, Raychaudhuri Utpal, Current Pharmaceutical-Design, Vol .17, (21) , 2011 , pp. 2196-2205(10), Bentham-Science-Publisher

14 Artificial sweeteners – a review. Chattopadhyay Sanchari, Raychaudhuri Utpal & Chakraborty Runu, Journal of Food Science and Technology, DOI 10.1007/s13197-011-0571-1, 2011, Publisher: Springer. 15.Role of plants (Neem Leaves & Mahogany seeds) on Diabetic Patients-A Critical Appraisal, Dutta Moumita, Raychaudhuri Utpal, Chakraborty Runu, Maji Debasish, Science and Culture, Vol.77, No.3-4. Indian Science News Association, 2011.

15 Cereal based functional food of Indian subcontinent: a Review, Das Arpita., Raychaudhuri Utpal. & Chakraborty Runu, Journal of Food Science and Technology. DOI 10.1007/s13197-011-0474-1, 2011, (( 49(6), 2012,pp 665–672)) Publisher: Springer.

16 Effect of Freeze-drying and oven drying on antioxidant properties of fresh wheatgrass, Das Arpita, Raychaudhuri Utpal. & Chakraborty Runu, International Journal of Food Sciences and Nutrition, (doi:10.3109/09637486.2011.644769) Publisher: Informa healthcare, 2011, ( Vol. 63, No. 6 , pp 718-721, September 2012 )

17 Optimization of Rice flour (Oryza sativa L) and Chapra (Fenneropenaeus indicus) Extrusion by response surface methodology--Hom Choudhury Mahuya , Chakraborty Runu, Sarkar Sreekanta , Raychaudhuri Utpal, Fishery Technology (48) , pp 155-162,2011, Publisher : CIFT, Cochin, India

18 Optimization of Rice Flour (Oryza sativa l) and Lali (Metapenaeopsis stridulans) Extrusion by Response Surface Methodology,Hom Choudhury Mahuya, Chakraborty Runu, Raychaudhuri Utpal , International Journal of Advanced Engineering Technology, January, 2011 Vol II Issue I, pp1-11, Publisher : Foundation of Computer Science, USA

19 Role of nutraceuticals in human health. Das Lipi, -Bhaumik Eshani, Raychaudhuri Utpal & Chakraborty Runu, Journal of Food Science and Technology, 49(2): 173-183, 2012, Publisher: Springer

20 Supplementation of common white bread by coriander leaf powder, Das Lipi, Raychaudhuri Utpal & Chakraborty Runu, Food Science and Biotechnology, 21(2): 425-433, 2012, Publisher: Springer

21 Quality enhancement of groundnut oil by addition of rice bran oil extract, Bardhan Jayeeta, Chakraborty Runu, Raychaudhuri Utpal, Natural Products: An Indian Journal.Vol. 8 ( 8 ), pp2-8, 2012 Publisher :Trade Science Inc

22 Study on Electrochemical Immunoassay methodology for Protein A: a modified approach towards detection and quantification of Staphylococcus aureus in food

samples, Majumdar Tania, Chakraborty Runu, Raychaudhuri Utpal, Research Journal of Chemical Sciences, Vol. 2 ( 8 ), pp 62-68, 2012, Publisher: International Science Congress Association.

23 Study on Enzyme-Linked Immunoassay and Polymerase Chain Reaction for the Identification and Quantification of Staphylococcus aureus in Pure Culture and Food Samples, Majumdar Tania, Chakraborty Runu, Raychaudhuri Utpal, ISCA Journal of Biological Sciences, Vol. 1(3), pp30-36, 2012, Publisher: International Science Congress Association.

24 Study on Factor H mediated identification of Staphylococcal Sbi protein in pure culture, Majumdar Tania, Chakraborty Runu, Raychaudhuri Utpal, Biochemistry: An Indian Journal, Vol. 6 (4), pp111-113, 2012, Publisher: Trade Science Inc.

25 Optimizing Process Conditions for Palm (Borassus flabelliffer) Wine Fermentation using Response Surface Methodology, Ghosh Satyabrata, Chakraborty Runu, Raychaudhuri Utpal, International Food Research Journal. Vol. 19(4), pp 1633-1639,2012, Publisher: University Putra Malaysia.

26 Kinetic Model of Natural Palm Juice Vinegar Production in Bioconversion of Palm Wine to Acetic acid using Acidophilic Bacteria and Optimization by Response Surface Methodology, Ghosh Satyabrata, Chakraborty Runu, Chaterjee Gourav, Raychaudhuri Utpal, Brazilian Journal of Chemical Engineering, Vol.29 ( 03 ), pp461-472, 2012 , Publisher: Brazilian Society of Chemical Engineering.

27 Sub-chronic toxicity study of the seeds of Swietenia macrophylla in wister rats-Moumita Dutta, Runu Chakraborty, Debasish Maji, Utpal Raychaudhuri, Science and Culture, Vol.78, No.1–2, 2012, Publisher : Indian Science News Association.

28 Effect of baking conditions on the physical properties of herbal bread using RSM, Lipi Das, Utpal Raychaudhuri and Runu Chakraborty, International Journal of Food, Agriculture, and Veterinary Sciences, Vol. 2 ( 2 ), pp 106-114, 2012, Publisher : CIB Tech

29 Characterization of extrudate prepared from Rice (Oryzasativa L) and Chapra (Fenneropenaeus indicus) by Twin Screw Extrusion, Hom Choudhury Mahuyai , Chakraborty Runu, Sarkar Sreekanta , Raychaudhuri Utpal, Fishery Technology , Vol. 49 pp 50-53, 2012,Publisher : CIFT, Cochin, India

30 Antimicrobial effect of edible plant extracts on the growth of some food borne bacteria including pathogens, Das Arpita., Raychaudhuri Utpal. & Chakraborty Runu, Nutrafoods, Vol.11, pp.99-104, 2012 , Publisher: Springer.

31 Antidiabetic and antioxidant effect of seeds in experimental type II diabetic rats, Moumita Dutta1, Utpal Kumar Biswas, Runu Chakraborty, Piyasa Banerjee, Debasish Maji, Mohan Chandra Mondal, Utpal Raychaudhuri, International Journal of Diabetes in Developing Countries, DOI 10.1007/s13410-012-0109-8, 2012, Publisher : Springer

32 Regeneration of pancreatic β-cells on streptozotocin induced diabetic rats under the effectof Swietenia macrophylla seeds, Moumita Dutta, Utpal Kumar Biswas, Runu

Chakraborty, Utpal Raychaudhuri, International Journal of Green Pharmacy. Vol.6, (4), pp 336-339, 2012, Publisher : Medknow publishers.

33 Optimization of Soy Dessert on Sensory, Color and Rheological Parameters Using Response Surface Methodology, Chattopadhyay Sanchari, Raychaudhuri Utpal & Chakraborty Runu, Food science and Biotechnology, Vol. 22 (1) , pp 47-54, (2013) , Publisher: Springer.

34 Effects of thermal treatments and germination on physico-chemical properties of corn flour, Prakash Bhattacharyya, Uma Ghosh, Hiranmay Gangopadhyay, Utpal Raychaudhuri, African Journal of Food Science Research , Vol. 1 (1), pp. 010--014 , 2013,©International Scholars Journals 2013,

35 Cryoprotective Effect of Shrimp Waste Protein Hydrolysate on Croaker Surimi Protein and Gel Characteristics during Frozen Storage, Satya S. Dey, Krushna C. Dora, Utpal Raychaudhuri, Subha Ganguly, Fishery Technology , Vol 50, No 1 , 2013, Publisher : CIFT, Cochin, India

36 Rapid Electrochemical Quantification of Food Borne Pathogen Staphylococcus Aureus Based on Hydrogen Peroxide Degradation by Catalase Tania Majumder, Runu Chakraborty, and Utpal Raychaudhuri, Journal of Electrochemical Society, Vol. 160 ( 4 ), 2013,pp. 75-78, 2013, Publisher :The Electrochemical Society, USA.

37 Development of PEI—GA modified antibody based sensor for the detection of S. aureus in food samples, Tania Majumder, Runu Chakraborty, and Utpal Raychaudhuri, Food Bioscience, Vol. 4, pp. 38—45, 2013, Publisher: Elsevier.

38 Pyrroloquinoline quinone A Redox cofactor and its involvement in biological system Satyabrata , Ghosh, Runu Chakraborty & Utpal Raychaudhuri , International Journal of Science and Nature, Vol 4 ( 3 ), pp. 371-380, 2013, Publisher : Society for Science and Nature, Lucknow, UP, India

39 Quality enhancement of mustard oil by tocotrienol rich fraction from rice bran oil---Bardhan Jayeeta, Chakraborty Runu, and Raychaudhuri Utpal, International Journal of Food Properties ( Accepted for Publication in 2013 ) Publisher : Taylor and Francis.

40 Incorporation of turmeric-lime mixture during the preparation of tomato puree, Chaitali Dutta, Banani Ray Chowdhury, Runu Chakraborty, and Utpal Raychaudhuri, African Journal of Food Science Research , Vol. 1 (2), pp. 018--020 , 2013,©International Scholars Journals 2013.

41 Competitive inhibition of Staphylococcus aureus in vacuum packed fish fillet by Lactic Acid Bacteria, S. Chowdhury, U. Roychoudhury, and K.C. Dora, The Asian Journal of Animal Science, Vol.7 ( 2 ), pp. 108-113, 2013, Publisher: Hind Institute of Science and Technology, India

42 Microencapsulation of probiotic bacteria and its potential application in food technology, Das Arpita.,Ray Sohini, Raychaudhuri Utpal. & Chakraborty Runu, Accepted ( 2013 ) for Publication in International Journal of Agriculture, Environment, & Biotechnology,

New Delhi Publisher 43 Optimization of Twin Screw Extrusion process for production of snack from

Aswagandha ( Withania soinifera ) Rice ( Oryza sativa ) and Chapra ( Fennero Fenneropenaeus indicus ) for antioxidant effect, Hom Choudhury Mahuya, Chakraborty Runu, Raychaudhuri Utpal , British Journal of Applied Science & Technology, ( Accepted in 2013 for publication with provisional PDF having reference of Journal Vol. 4 ( 9 ), pp.1334—1352, 2014 ), Publisher :SCIENCEDOMAIN International.

9.4.5 Relevant Patents

A process for preparing storage stable low fat and low cholesterol goat meat: No. 221577, dated 25.06.2008.

A process for preparing a sea food including , preparing and mixing crustacean powder, small fish powder and Aswagandha extract in the manner such as herein described and extruding the said mixture with suitable extruding means: Journal Issue No 18/2009 , Application No. 563/KOL/2009A Published dated 01.05.2009.

A process for preparing nutrient fortified Ayurvedic sweets like sandesh and rosogolla containing at least one herb: No. 212143 dated 28.10.2003.

Process for preparing lactobacillus culture having improved potency and storage-stability and their use in probiotic food like herbal yoghurt (Dahi): No. 195513 dated 26.12.2002.

A process for making storage –stable edible food materials from kernels of Gorgon nuts: No. 187500 dated 22.2.2001.

9.4.6 Facilities available

Equipments Specification Brookfield viscometer DV-E (USA) Spectrophotometer Hitachi U-2000 (Japan) Ultra deep freezer (-80°C) ICT (Induia) Rotary vacuum evaporator Shimadzu (Japan) Single pan digital balance Precisca Zo 5 ASCS (Swiss) Cold centrifuge Remi C-245 Freeze dryer ICT Instron texture anayze London Langmuir film balance UK Ultra filtration unit Millipore (USA) Stanley Belling ram digital refractometer UK Fermentor (5L) Eyela (Japan) Atomic absorption spectrophotometer Thermofisher Scientific HPLC JASCO Supercritical carbon dioxide extraction unit Applied Separations (USA)

Spray dryer Buchi (Switzerland) Ultrasonic Homogenizer (Model Labsonic M) Sartorrius (Germany) Turbo Vap LV Concentration Workstation Biotage (Sweden) Homogenizer with suitable generator IKA (Germany) Co-solvent pump for supercritical unit Applied Separations (USA)

9.4.7 Ongoing Work under UPE II – 2012-14

Title:Antioxidant property of tea:

Authors: Jayeeta Bardhan, Runu Chakraborty, Utpal Raychaudhuri

Abstract: This study was performed to compare the antioxidant power of different tea samples available in the market. Two types of tea are available: green tea and black tea (CTC and orthodox).Moreover herbal tea is also available where in addition to tea, some aromatic compounds from natural sources are added. Total phenolic content and total flavonoid contents were measured. Antioxidant activity were determined by performing DPPH assay, FRAP assay and TBARS assay. Our results show antioxidant potential of green tea is almost equal to black tea followed by peach tea, black current tea,strawberry tea and raspberry tea respectively.

• It was observed that a linear positive relationship existed between the antioxidant potential and total phenolic content and total flavonoid content of the tea samples.

• The antioxidant potential of green tea and black tea are not only because of phenolics and flavonoids but also because of catechin and their derivatives like theaflavin and thearubigin.

9.4 8. Work plan during 2014-17

• Natural antioxidants to be extracted from various tea samples and to be quantified using HPLC

• Parameters like infusion time, infusion temperature influencing the extraction process to be studied

• Effectiveness of these antioxidants in comparison to synthetic antioxidants in improving the food quality to be studied

• Extracted antioxidants to be used in fortification of food • Antimicrobial effect of tea and synergistic effect with antibiotics to be studied