5th IgCLL Educational Workshop Program

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Immunoglobulin Sequence Analysis in Chronic Lymphocytic Leukemia

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Wednesday 25 September 2013 Program

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19:00 Welcome dinner for invited speakers (Hotel International)

Thursday 26 September 2013

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8:50 Sarka Pospisilova (CEITEC MU; University Hospital Brno; CZ)

Welcome

Keynote Lecture

9:00 Nicholas Chiorazzi (The Feinstein Institute for Medical Research, New York, US)

The turbulent life history of CLL

Session I - Modern prognostication in CLLChair Sarka Pospisilova (CEITEC MU; University Hospital Brno; CZ)

9:45 Richard Rosenquist (Uppsala University, Uppsala, SWE)

The genomic landscape of CLL

10:10 Kostas Stamatopoulos (G. Papanicolaou Hospital, Thessaloniki, GR)

Immunogenetics and prognostication

10:35 Paolo Ghia (Universita Vita-Salute San Raffaele, Milano, IT)

Biological prognostic markers: a critical reappraisal

11:00 Coffee break

26. 9. – 27. 9. 2013, Hotel International, Husova 16, Brno, Czech Republic

Session II - IG sequence analysis in CLL: technical aspectsChair Richard Rosenquist (Uppsala University, Uppsala, SWE)

11:30 Frederic Davi (Hðpital Pitié-Salpêtrière, Paris, FR)

Mechanisms of immunoglobulin diversity

11:50 Anton Langerak (University Medical Center, Rotterdam, NL)

From the patient to the sequence: Primers, PCR, Detection of clonality, Sequencing

12:20 Marie-Paule Lefranc (Université Montpellier, Montpellier, FR)

Online tools for Interpretation of IG sequences and navigation through the IMGT web- resources

12:50 Lunch

Session III - Interpretation of IG sequencesChair Anastasia Hadzidimitriou (Centre for Research & Technology Hellas, Thessaloniki, GR)

14:00 Veronique Giudicelli (Université Montpellier, Montpellier, FR)

How to use the IMGT/V-QUEST tool

14:30 Basic exercises I

15:15 SolutionsKarla Plevova (CEITEC Masaryk University; University Hospital Brno; CZ)

15:45 Coffee break

16:15 Basic exercises II

17:00 SolutionsVasilis Bikos (CEITEC Masaryk University, CZ)

18:00 Visit to Mendel Museum, social event

5th IgCLL Educational Workshop Program

Friday 27 September 2013

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Session IV - Interpretation of IG sequences: advanced exercisesChair Chrysoula Belessi (General Hospital of Nikea, Athens, GR)

8:30 Advanced exercises I

9:15 SolutionsLesley Ann Sutton (Uppsala University, Uppsala, SWE)

9:45 Advanced exercises II

10:30 SolutionsAndreas Agathangelidis (Università Vita-Salute San Raffaele, Milano, IT)

11:00 Coffee break

Session V - IG sequence analysis for everyoneChair Paolo Ghia (Universita Vita-Salute San Raffaele, Milano, IT)

11:30 Richard Rosenquist (Uppsala University, Uppsala, SWE)

How to report IG sequence data in clinical routine

11:50 Kathleen Potter (University of Southampton, Southampton, UK)

Methodological harmonization, guidance

Session VI - Where do we go now?Chair Kostas Stamatopoulos (G. Papanicolaou Hospital, Thessaloniki, GR)

12:10 Fiona Murray (Uppsala University, Uppsala, SWE)

Recombinant antibodies in autoimmunity and malignancy: a key to improved understanding of immune processes

12:30 Anton Langerak (University Medical Center, Rotterdam, NL)

Immunogenetics in the NGS era: challenges and limitations

12:50 Sarka Pospisilova (CEITEC MU; University Hospital Brno; CZ)

Concluding remarks

13:00 Lunch

5th IgCLL Educational Workshop Program