264 PATENT ABSTRACTS

than somatostatin. The compounds have the properties o f inhibiting the release o f glucagon, growth hormone and insulin. Certain of the compounds also are capable of inhibiting the release of gastric acid secretions. The com- pounds are particularly useful in the treatment of acromegaly, diabetes, diabetic retinopathy and peptic ulcers. These cyclic hexapeptides are pre- pared by the solid phase method.

4 5 2 2 8 1 4

C O M P O S I T I O N O F M A T T E R FROM C R Y P T O S I P H O N I A

W O O D i l U S E F U L F O R T H E T R E A T M E N T O F H E R P E S

S I M P L E X V I R U S

Arthur M Nonomura. Raphael Pappo assigned to Pappo Raphael

A water extract of homogenized Cryptosiphonia woodii is useful for the treatment of herpes sim- plex viral infections. The active agent in the extract is a polysaccharide containing glucose and galactose. Herpes infections may be treated in subjects, e.g. human patients, by ad- ministering to the subject an effective amount of an aqueous extract of C. woodii, particularly a water extract. This treatment method is effective for treating subjects both prior to and sub- sequent to infection. It may involve topical application to alleviate symptoms associated with herpes infections or desirably may be sys- temic, e.g. by oral administration, to eradicate the virus and thereby prevent symptom recur- rence.

4522918

P R O C E S S F O R P R O D U C I N G M O N O C L O N A L A N T I B O D I E S

R E A C T I V E W I T H H U M A N B R E A S T C A N C E R

Jeffery Schlom, David Colcher, Marianna Nuti, Patricia H Hand. Faye Austin

Monoclonal antibodies demonstrating a reac- tivity with human breast cancer are produced. The hybridoma cultures secreting immuno- globins are produced by hydridoma technology. Splenic lymphocytes of mice, immunized with membrane-enriched fractions of metastatic human mammary carcinoma tissue are fused with the NS-I non-immunoglobulin-secreting murine myeloma cell line. Screening of immuno- globulin reactivities and double cloning of cul- tures yielded 11 monoclonal antibodies that demonstrated activities with the sudhce of human mammary tumor cells and not with the surface of apparently normal human tissues. These monoclonal antibodies aid in the dia- gnosis, prognosis and treatment of human breast cancer,

4 5 2 2 9 1 9

M E T H O D O F P R O D U C I N G A N T I B A C T E R I A L A G E N T S A N D

B I O C O N V E R T I N G M I C R O O R G A N I S M T H E R E F O R

Barbara B Shreve, Jan Turner assigned to Eli Lilly and Company

o

CHa

CH30 CHI CH2~CHO

CJH3 CH CHI O ~ N--CH:

CH~ O ~ f f ~ R

CH~

Improved bioconverting strain of Streptomyces thermotolerans useful in preparing tylosin esters and new antibacterial macrocin or lactenocin ester derivatives of the formula: See Patent for Chemical Structure wherein R is formyl or hydroxymethyl; RI is hydrogen, acetyl or pro- pionyl; R2 is hydrogen or See Patent for Chem- ical Structure and R3 is hydrogen, acetyl, propionyl, n-butyryl or isovaleryl; provided that one of R 1 or R3 must be other than hydrogen.

4 5 2 4 0 2 5

H Y B R I D O M A C E L L L I N E S A N D M O N O C L O N A L A N T I B O D I E S T O

T H E O P H Y L L I N E

John E Geltosky assigned to E I D u Pont de Nemours and Company

Monoclonal antibodies to theophylline having 5 ~ or less cross-reactivity with caffeine and the continuous hybrid monoclonal cell lines for their production are provided. These antibodies are useful in a particle-enhanced turbidimetric in- hibition immunoassay for theophylline.

4524026

N O V E L P R O T E I N O U S C A N C E R - C E L L P R O L I F E R A T I O N I N H I B I T O R Y F A C T O R S

Yoshio Sakagami, Hofumi Manabe, Jugaoka, Meguro ku. Tokyo. Japan

A new series of cancer-cell proliferation in- hibitory factors which inhibit tumor cells, are nontoxic to humans and animals, and show no appreeiatab]e cffccts upon normal ceils are dis- ck)sed and characterized.