2016 U-M Tech Transfer Impact Report · ing with the prestigious Rice Business Plan Competition in Houston, where they captured a $50,000 second- ... ing preliminary work on an advanced

A

2016U-M TECH TRANSFERI M P A C T R E P O R T

B

University of Michigan researchers provided the fuel for another robust year of tech transfer activity. In fiscal year 2016, researchers from across campus provided us with 428 new inventions, the second highest number of record. This strong activity was aided by the engagement activities of our school/college innovation partners, our Digital Discovery program for apps and software, and the outreach and services of our tech transfer professionals. Our staff filed 176 new patent applications, completed a record-setting 173 option and license agreements and helped to launch 12 new business startups. The University of Michigan has established a track record of achievement that is recognized as among the top 10 of all universities. This level of achievement is a testament to the high quality of work by our researchers, the commitment of the University and the support from our business, venture, government and community partners.

This report documents the impact of tech transfer with stories that describe the contributions of our technology, people and partners to the economic vitality and quality of life of our region, and beyond. We hope these stories will provide another dimension of the impact of the University of Michigan and inspire you to support our contributions to our community, our state and our nation.

Tech Transfer Impact

ASSOCIATE VICE PRESIDENT U-M Tech Transfer

The U-M Tech Transfer executive team (from left): Rick Brandon, Ken Nisbet, Bryce Pilz, Drew Bennett, Jack Miner

1

Innovation and entrepreneurship are part of the fabric of a great research university. Innovation transforms the university’s discoveries and ideas into new products and services that enrich our lives and revitalize our economies. Entrepreneurship extends some innovations into exciting new startup ventures that can influence entire industries. Our technologies, whether licensed to existing companies or to entirely new business startups, provide opportunity and resources for our state and our nation.

Tech transfer plays a key role in our University’s efforts to foster innovation and entrepreneurship. Our licensing professionals work with faculty to encourage innovation and develop these opportunities for our business partners. Our Tech Transfer Venture Center acts as a one-stop hub for entre preneurs and investors interested in U-M startup opportunities. And our activities help connect faculty and students to real-world research, educational, and business opportunities that support the core missions of the University.

“Through technology transfer, U-M actively engages industry, venture, and community partners in the transformation of discoveries into new products, processes, and services that help society realize the promise of university research.”

S. JACK HU | U-M VICE PRESIDENT FOR RESEARCH

“Being a source of innovation and entrepreneurship is a core element of our contribution to society as a world-class public research university. U-M’s strengths in research across many academic disciplines result in a capacity for innovation that has enormous potential for economic and societal impact.”

MARK S. SCHLISSEL | PRESIDENT, UNIVERSITY OF MICHIGAN

Innovation + Entrepreneurship

2

Ramses Alcaide was just eight years old when his uncle Margarito lost both his legs in a car crash. That tragedy affected Alcaide deeply. Seeing his physically altered uncle, Alcaide was awed by his courage and mental fortitude. “He refused to give up,” Alcaide says when asked of his uncle’s influence. “He defied the odds and learned to walk again. And he inspired the passion I’ve dedicated my life to: creating technology that allows people to control mechanical objects with their brains and level the playing field for the disabled.”

This was the impetus that drove Alcaide to pursue a degree in electrical engineering with the hope of advancing prosthetic design and function. However, after graduating, Alcaide realized that, if he was really going to effect change, he could not just develop technology—he needed to understand the brain.

That’s when he joined the U-M Direct Brain Interface (UM-DBI) Laboratory. There, working alongside Dan Ferris, Ph.D., and lab co-founders Jane Huggins, Ph.D., and Seth Warschausky, Ph.D., Alcaide developed algo-rithms and artificial intelligence software for a revolu-tionary computer-brain interface that makes it possible for human beings to control objects with their thoughts.

Working with U-M Tech Transfer staff, the UM-DBI team applied for a patent and laid the groundwork for Neurable with a two-phase business plan. During the

first phase, they would direct their efforts toward the growing augmented and virtual reality markets. Then, once established in the consumer market, the Neurable team would create a cognitive assessment tool for patients with cerebral palsy and introduce a suite of assistive products for the disabled.

The team has gone from one success to another, start-ing with the prestigious Rice Business Plan Competition in Houston, where they captured a $50,000 second- place prize plus more than $300,000 in funding from the Owl Investment Group. That event was followed by high-level discussions with corporate giants Disney, Sony, LEGO, and Samsung. Neurable’s first round of seed funding, totaling $1.5 million, will be used to develop a software application development kit for virtual and augmented reality programmers.

Seen above, the newest generation of the Neurable computer-brain interface uses dry sensor technology to detect and interpret P300 brain waves within 500 milliseconds, thereby enabling users to move three- dimensional objects with their brain activity. By providing a natural, fluid and easy way for humans to control Virtual Reality and Augmented Reality applications, this technology could well become the standard for brain-computer interaction.

Setting a New Standard in Brain-Computer Interaction

Neurable

3

State-of-the-Art Ice Detection Technology

Intelligent Vision Systems

Climate and Space Science Professor Nilton Renno loves solving problems. And as he readily admits, “I’m always looking for problems related to my research interests that are fun to work on and can have a significant impact on society.”

Renno’s first startup, Electric Field Solutions, was based on electric field detection technology he devel-oped for NASA’s missions to Mars. Some years later, NASA’s planned landing in Mars’ polar region piqued his interest in ice detection. As a private pilot, he was keenly aware of icing problems and their potentially deadly consequences. “One winter day,” he recalls, “I found my plane frozen on the taxiway and I thought: icing is a problem worth working on.”

Within a year, Renno had filed an invention report describing a technology for detecting the presence of ice, super-cooled water and snow. U-M Tech Transfer helped him file three patent applications for monitor-ing ice detection in clouds; on aircraft components; across other modes of transportation; and on roads, bridges, runways, and other surfaces. Working with U-M Tech Transfer staff, an approach to commercialize his ideas was constructed and developed.

In 2016, Renno launched Intelligent Vision Systems (IVS) in collaboration with Dexter Research, a local Michigan firm. IVS is working with several leading aerospace and automotive manufacturers and automotive suppliers to better understand the integration of ice detection technology with their products.

Renno credits U-M Tech Transfer with playing a central role in bringing the technology to market. “Transforming a research discovery into a marketable product is not easy,” he says. “U-M Tech Transfer provided me the encouragement and resources, from mentoring to intellectual property protection to devel-opment funding. It’s great to have these resources and expertise to help transfer my ideas to market.”

Professor Nilton Renno, seen below, invented the IVS ice detection technology to detect black ice and activate traction control and braking systems for individual vehicles. It can function as an infrastructure warning system on roads, bridges, runways, and parking lots. It can also alert pilots to the presence and size of super-cooled water droplets that cause airplane icing.

4

Creating a Breakthrough in Laparoscopic Instruments

FlexDex Surgical

The introduction of minimally invasive surgery in the early 1980s marked a new era in medicine. Also known as laparoscopic surgery, this technique of performing operations through small incisions results in fewer com- plications, shorter procedures and faster recovery times.

But for more than two decades, laparoscopy was hindered by available technology. The choices? Rigid instruments that—while affordable—were awkward and limited in dexterity. Or room-sized robotic devices that were intuitive and flexible, but cost millions and required extensive support and training.

Mechanical Engineering professor Shorya Awtar and Surgery professor James Geiger (seen below) joined forces with medical industry entrepreneur Greg Bowles to create a new startup company, FlexDex Surgical, to develop minimally invasive tools.

With help from U-M Tech Transfer and working with U-M students, Awtar and Geiger overcame several technical challenges and developed highly functional prototypes. And Bowles provided the industry experience to enter this complex surgical care market.

“My firsthand experience selling surgical robots convinced me they bring tremendous clinical value to patients. However, hospitals, surgeons and nurses desperately needed a simple solution that doesn’t

burden their system with unsustainable costs or complexity,” said Bowles.

FlexDex was awarded a Small Business Innovation Research Phase II grant from the National Science Foundation in 2014 and closed a Series A private investment at the same time. After appointing CEO Tom Davison, a serial entrepreneur with numerous successful medical device startups, FlexDex secured another $5 million in Series B funding in 2016 and is rolling out its first product: an articulating needle driver for suturing and knot-tying. The company employs more than a dozen people, including several U-M graduates, and operates out of an engineering and manufacturing facility in Brighton, Michigan.

FlexDex is closing in on its goal of building the best, most affordable and intuitive suite of laparoscopic and endoscopic devices on the market.

FlexDex offers a product that combines the simplicity and affordability of hand-held instruments with the intuitive dexterity of multimillion-dollar robotic devices. The product uses a Virtual CenterTM and Three-axis GimbalTM mounting on the wrist that allows users to transmit hand movements directly to the end point of the surgical device, and an n nity andleTM that offers a natural feel and comfortable ergonomics.

5

With a grant from the U.S. Navy, Mechanical Engi-neering professor Ellen Arruda has been exploring ways to diminish the effect of impact blast, with the goal of creating a material that dissipates energy before it can damage delicate body structures. Follow-ing preliminary work on an advanced combat helmet, Arruda turned her attention to football helmets, which have not changed significantly since the 1960s.

Each year, sports and recreational injuries result in as many as 380,000 cases of Traumatic Brain Injury (TBI) in the U.S. alone. In 2012, young athletes accounted for nearly half of those injuries. The National Football League (NFL) has acknowledged that brain trauma affects approximately one-third of all retired players.

“The modern helmet is designed solely to prevent skull fracture, something it does well,” Arruda notes. “The new concern is preventing TBI, which is caused not only by force, but also by the transmission of im-pulse energy through a helmet.”

Since 2015, Arruda and colleagues Professor Michael Thouless and graduate student Tanaz Rahimzadeh have been participating in Head Health Challenge III. Funded by the NFL, General Electric, the National Institute for Standards and Technology, and Under

Armour, the competition challenges research scientists to develop a material that will optimally absorb impact in applications such as football helmets, thereby reducing the likelihood of TBI.

The solution developed by Arruda’s team is known as MITIGATIUM. Their composite material combines elastic and visco-elastic layers that protect against frac-tures and TBI by reducing both pressure and impulse during impact.

Now, as one of five finalists in the challenge, the team has a $250,000 grant to develop a prototype helmet. Working with U-M Tech Transfer, they are collaborat-ing with helmet manufacturers to create customized, protective material combinations for specific helmet shells. Looking ahead, they hope to use their design to improve everything from automotive bumpers and playground surfaces to packaging materials.

Protecting Athletes from Traumatic Brain Injury

MITIGATIUMCurrent football helmets only protect against skull fractures caused by stress waves. But MITIGATIUM, a new compound developed by U-M Professor Ellen Arruda (seen above) and her team, uses a combina-tion of elastic layers to modulate the stress waves and visco-elastic layers that protect against TBI by dissipating the energy before it reaches the brain.

428

135Patents Issued

Invention Reports

173License/Option

Agreements

2016

12New Business

Startups

I N R E V I E W

Invention Reports

500

400

300

2002011 2012 2013 2014 2015 2016

License Agreements

to established companies

to startups

License Revenue

80

60

40

20

0 2011 2012 2013 2014 2015 2016

royalties

equity/paid-up royalties

15CompaniesHoused in

U-M VentureAccelerator

2000+Jobs Created

Since 2000

$23Million

in Revenue

AEROSPACE ENGINEERINGToolkit for the Analysis of Composite StructuresEnergy Harvesting for Leadless PacemakersSoftware for Lifetime Prediction of Composite MaterialsHypersonic Vehicle Simulation CodeAdaptive Input Estimation for Enhanced Tracking of Maneuvering TargetsFerroelectric Polymers from Dehydrofluorinated PVDF Retrospective Cost Adaptive with Concurrent Model IdentificationA Graph Theoretical Based Method for Analyzing Conduction ProblemsHybrid Partial and Full Step Quadratic Solver for Model Predictive Control of Diesel Engine Air Path Flow and Methods of SameMethods and Systems for Catalyst Health MonitoringMethods and Apparatus for Assessing Tire Health Through Monitoring Effective Rolling RadiusMagnetic Nozzle Thrust VectoringRetrospective Cost Adaptive Control for Feedforward Active Noise and Vibration Control

ANESTHESIOLOGYTrauma WatchAutologous Blood Scale

ART & DESIGNWireless Networking Platform

BIOMEDICAL ENGINEERINGDetecting and Localizing Ultrasound Induced Bubble Clouds Using Magnetic Resonance ImagingCarbon Fiber and Silicon Hybrid ArraySynthetic Three-Dimensional Fibrous Structures Formed from Oppositely-Charged MacromoleculesNanoparticles for the Induction of Immunological ToleranceLiquid Tunable Ring Resonators on Chip, Their Design, Fabrication, and ApplicationMicrofluidic Device for the Prospective Assessment of Thromboembolism RiskMonolithic Integrated 3D MEMS Scanner for Switchable Real Time Vertical/Horizontal Cross-Sectional ImagingPulse Amplifier for Driving Ultrasound TransducersReduced Membrane Permeability from Novel Tetraether LipidsMacroporous Polyethylene Glycol Scaffolds for Cell TransplantationModified Nanoparticles for Tuning Induction of Immunological ToleranceOptical Quartz Crystal Microbalance ArrayICG LasingMethods to Improve Protein Functionalization of Polymer ScaffoldsMiniaturized Helium Discharge Photo-Ionization DetectorMulti-Channel Multi-Dimensional Comprehensive GC

CELL & DEVELOPMENTAL BIOLOGYA Genetically Encoded Activator and Controller of the Mitotic CheckpointPlasmid for Efficient CRISPR/CAS Modulation of Embryonic Stem CellsSecondLook Neuroanatomy Mobile ApplicationSecondLook Musculoskeletal Anatomy Mobile ApplicationMichigan eHistology Virtual Slides

CHEMICAL ENGINEERINGBranched Aramid Nanofibers and Composites ThereofStretchable Substrates for Enhanced Raman Scattering AnalysisOrally Administered Sensing ParticlesProduction and Engineering of Peptide-MHC Complexes and Uses ThereofSimple Platinum Reference Electrode and the Application on pH and Oxidation Reduction Potential MeasurementMicro-Kirgami Adaptive Optics Chiral Graphene Quantum Dots and NanocarbonsStereo Conformational Switching, Chiroptical Reporting of Intracellular Localization and the Use of Nanoscale Chiroplasmonic Biomedical Agents Based on Particle Dimers in Biomedical TechnologiesIntegrated Directional Air Flow Sensor with Multifunctional CapabilityShielding Device for Diesel Particulate SensorMetallic Chabazite Zeolite CatalystsTemplated Synthesis of Shape-Controlled Polymeric Nanofibers by Chemical Vapor Deposition into Liquid CrystalsHand-Held Wireless Platform and Optics for Measurement of DNA, RNA, MicroRNAs, and Other Markers of Pathogens, Genetic Diseases, and CancerMethod to Improve Neurotrophin-3 Delivery Via Specific Peptide Interactions

CHEMISTRYMetallacrowns as Cellular Fixatives and Imaging AgentsBiogas Purification SystemMethod to Microfabricate Microdialysis ProbesStable and Highly Active Nickel(0) Catalysts of N-Heterocyclic Carbene Ligands Process for Fluorinating Compounds 4Hydrogen-Bond Surrogate Peptides and Peptidomimetics for P53 ReactivationPhoto-Release of Nitric Oxide from S-Nitrosothiol Impregnated Materials for Inhalation TherapyExpedited Position-Specific Labeling of RNA through Reversible, Site-Specific Blockage of TranscriptionFormation of High-Molecular Weight Polyethylene from a Sterically Unencumbered Iron-Based CatalystHigh-Confidence Single-Molecule Detection of DNA Biomarkers Using SIMREPS and Dcas9-Guided MeltingMercaptopurine HemihydrateProcess for Selective Methane C-H BorylationRendering Non-Energetic Microporous Coordination Polymers ExplosiveNucleophilic, Radical and Electrophilic Trifluoromethylation Using FluoroformOrganic Catholyte Materials for Redox Flow Batteries

CIVIL & ENVIRONMENTAL ENGINEERING

Body Silhouette-Based Posture Classification for Manual Workers Using Virtual Training DatasetsA Computational Framework of Dimension Reduction Modeling and Similarity Measurement for the Detection of Unsafe ActionsMeans and Methods for Treating Copper-Related Diseases

CLIMATE AND SPACE SCIENCES AND ENGINEERING

Using a Wavefront Sensor to Determine Unknown Aberrations in an Optical System

ASIC CorrelatorClassroom Active Participation in Computer SimulationsNavigation Satellite Signal GeneratorBeacon and Inertial Sensor Localization TechnologyTorque Rods for Spacecraft Attitude Control

COMPUTATIONAL MEDICINE & BIOINFORMATICS

Signal Processing AlgorithmUltrafast and Comprehensive Identification of Peptides from Tandem Mass SpectraAutomated Analysis of Vasculature in Coronary AngiogramsAutomated Decision Making System for Analysis Microcirculation VideoThe Index of BreakabilityData-Guided Controllability

DENTISTRYPeptide-Mimetic Anticancer PolymersPyrrolopyrimidine Nucleosides and Analogs ThereofImmortalized Mouse Temporomandibular Joint Disc Cell Clones with Multi-Lineage Differentiation CapacityMulti-Material Simulation for Medical Phantoms with 3D PrintingClinical Augmented Reality Evaluation of Patient Brain Activation in Real-TimeClinical Augmented Reality Evaluation and Decoding of Patient’s Brain Activation in Real-Time

DERMATOLOGYSTEAP1 and STEAP4 Have a Key Role in Amplifying Inflammatory Skin ReactionsVgll3 is a Key Regulator of Gender Specific Immune DysregulationReduction of Retinoid Dermatitis by Inhibition of Amphiregulin Processing

EDUCATIONBooks of Lesson Plans for Preschool TeachersOnline Review System for Middle School Students

ELECTRICAL ENGINEERING & COMPUTER SCIENCE

Online Audio Authentication SystemProactive Driver MonitoringHash-Chain Based CAN Sender IdentificationMinimum Zone Flatness Tolerance AlgorithmWireless Charging System for Charging Vehicular BatteryIntegrated Micro-Lens for Photovoltaic Cell and Thermal ApplicationsA Platform and System Architecture for Intelligent Cloud ServicesDrift Tolerant Read/Write Scheme for Multi-Bit Resistive RAMVehicle Trajectory DeterminationField-Based Torque Steering ControlOnline PER-Feature Descriptor CustomizationComputer Tool for Brachial Plexus Palsy TherapyComputer Tool for Keeping Diary While in Intensive Care UnitComputer Tool for Collaborative Play for Child with Autism Spectrum DisorderYour Own Planner: An Interactive Search Engine for Smart TravelingSmart Anatomic Recognition System to Guide Emergency Intubation and ResuscitationAn Active Stimulation Artifact Cancellation Scheme for a Bi-Directional Neural Interface Integrated Circuit

Adaptive Caching AlgorithmsA Technique to Enhance DRAM Self-Refresh Modes for Idle Power ReductionRegister File Virtualization in Throughput MachineDiscontinuous Energy HarvesterSimplified Load/Store Alias Detection in Dual-Pipeline CoresBlended Learning Platform 1.0Baseband Processing Circuitry for Low Power Wake-Up ReceiverHuman Adult Epithelial Stem Cells in Tissue RegenerationPowerBladeRegular Expression Matching for HAWKStructure-Based Point-Cloud SparsificationFingerprinting Electronic Control Units for Vehicle Intrusion DetectionSmart Memory for Trusted ComputingMethods and Systems to Protect MEMS Sensors from Intentional Acoustic InterferenceA Robust 12T SRAM Cell with Improved Write Margin for Ultra-Low Power ApplicationsAn Efficient Division Circuit for Stochastic ComputingFlowFence4-bits Analog to Digital Convertor Comprising Spoof Surface Plasmon Polariton WaveguideVAuth: Continuous Authentication for Voice AssistantsAnalog-Digital Hybrid Controller Architecture for Load-Adaptive Power Transistor Scaling in PWM Switching Power ConverterNon-Destructive Epitaxial Lift-off of Single Junction Photovoltaic CellLinkDroid: Reducing Unregulated Aggregation of App Usage BehaviorsArea-Energy Efficient Analog Front-End Architecture for Multi-Channel Neural Recording SystemA Portable Artificial Lung (PortAL) for End Stage Lung DiseaseOrganic Light Emitting Diode Having a Mixed Blocking LayerAg-Nanowire Enhanced Electrochromic DevicePlanar Solar Tracking System Integrated with Solar Cells and 2-Dimensional ConcentratorsSize Selective 2D Spatial Trapping of Nano and Micro ObjectsWireless Power Transfer Using Multiple Near-Field PlatesHigh-Energy Exicted State Manager Materials for Long-Lived Blue Phosphorescent Organic Light-Emitting DiodesFull-Band RF BoosterNew Solar Cell Device StructureMethod to Charge Lithium-Ion Batteries with Both User and Cell AwarenessMini-Parabola Concentrator Integrated with Ball LensFull Wave Simulations of Photonic Crystals and Metamaterials Using the Broadband Green’s FunctionsRobotic All-Direction Through-The-Wall Imaging SystemExploiting Safe Mode of In-Vehicle Networks to Make Them UnsafeAmbient Luminance and Color Correction Through Organic Light Emitting Diode and Organic Photodetector Sub-Pixel IntegrationTransparent and Flexible Conductors by Additive Processes and Applications ThereofEnhanced OLED Outcoupling by Suppressing Surface Plasmon Modes

Force Sensing Based on Structure-Borne Sound PropagationLight-Field Photodetectors and Imaging Devices Based on Atomic Layer Crystals and Their HeterostructuresSecuring Information Exchange Between Internal and External Entities of Connected VehiclesSub-Electrode Grid in Top-Emitting OLEDsEffective Compound Semiconductor Substrate for Non-Destructive Epitaxial Lift-OffITO/MoO3 Cathode for Top-Emitting or Transparent OLEDsAccelerated and Distributed Iterative Coordinate Descent for Model-Based X-Ray CT ReconstructionIntegrated Compound Parabolic Concentrator with Hemispherical Lens for Concentration PhotovoltaicsAssembly Processes for Three-Dimensional MicrostructuresLow-Noise Large Dynamic Range Multi-Axis Accelerometers Made From Thick SiliconGyroscope and Fabrication ProcessStacked Compound Parabolic Concentrators Integrated with Multiple Dielectric Layers for Wide Acceptance AngleA Rational-Conversion-Ratio Switched-Capacitor DC-DC ConverterPlasmonic Lithography for Patterning High Aspect-Ratio NanostructuresTransparent Displays Based on Light ExcitationLossless Neural Signal Compression Scheme for Massive-Parallel Neural Recording MicrosystemsEfficient Sparse Convolution for Deep LearningAcoustic DiodesPiezoelectric Acoustic CirculatorsNon-Thermal Semiconductor Doping via Ultrafast Laser IrradiationHaptic Wristband for People with Low VisionComputationally Efficient 3-D Finite-Element-Based Dynamic Thermal Models of Electric MachinesSoftware and Tools for a Network Reputation SystemA Highly-Compliant Microneedle Array for Interfacing Nervous TissueLocally Doped Excited State Manager for Long-Lived Blue PHOLEDsField-Programmable Crossbar Array for Reconfigurable ComputingA Variation-Tolerant Voltage ReferenceProgressive Cellular Architecture for Microfabricated Gas ChromatographPassive Infra-Based Gesture Recognition System for Smart DevicesThe Concept of Wellbore Telemetry Using the Drilling Pipe and Drilling Mud as Single Conductor Transmission Line and the Design of a Compact Borehole TM Wave TransducerFour-Dimensional Augmented Reality Models for Interactive Visualization and Automated Construction Progress MonitoringNanoscale Temperature SensorStacked Balanced Resonators

EMERGENCY MEDICINEZinc Oxide Nanoparticles as Enzyme Inhibitors and AntimicrobialsWaveform Annotation SoftwareEnsemble Beat Detection System for Non-Homogeneous Waveforms Collected by Patient MonitorsDetection of Intradialytic Hypotension Using a Miniature Piezoelectric Based Ring

Estimation of Peripheral Vascular Resistance Using a Miniature Piezoelectric Sensor

EPIDEMIOLOGYA Plasmid Vector for Fluorescence-Based Reporter Studies

FAMILY MEDICINEUtilizing Consumer Health Informatics to Support Management of Hypertension MyVoice: Real-Time Text Message Polling to Give Adolescents a Voice

HUMAN GENETICSHigh-Density Genotyping Panel for Genetic Analysis of Outbred RatsMouse Model 2 of SCN8A Epilepsy

INDUSTRIAL & OPERATIONS ENGINEERING

A Branch-and-Price-and-Check Model for the Vehicle Routing Problem with Location Resource Constraints Optimizing Infrastructure Enhancements for Evacuation PlanningBenders Decomposition for Large-Scale Prescriptive Evacuations

INSTITUTE FOR CLINICAL & HEALTH RESEARCH

Responsible Conduct of Research for K Awardees (RCR4K) ExportExporting the Practice Oriented Research Training Program

INTEGRATIVE SYSTEMS & DESIGNExtendEd Platform

INTERNAL MEDICINEInhaled Liposomes Encapsulating Recombinant Suppressor of Cytokine Signaling (SOCS) Molecules for the Treatment of Inflammatory Lung DiseasesLiposomal Delivery of SOCS3 to the Lung for the Treatment of Lung CancerMotility CatheterTransaortic Leadless PacingTransgenic Rabbit Models for Cystic Fibrosis Extracorporeal Ultrasound to Enhance AngioplastyDiapin Improves Glucose Homeostasis and Treats Diabetes by Mediating Gut MicrobiomeMethod for Reducing X-Ray Dose and Contrast Dose in Contrast Based ImagingMethod for Localizing, Marking and Announcing Sources of Cardiac FibrillationNude Rabbits and SCID RabbitsTransgenic Rabbits for Animal PharmingMultiplexed Translucent Balloon Catheter Treating Purinergic Dysregulation in Pulmonary HypertensionMethod to Improve Electrodes-Endocardium Contact of CathetersProinsulin Dimerization Interface as a Target for the Treatment of DiabetesUsing Mixed Lineage Leukemia Inhibitors to Treat Neuroendocrine TumorsGeneration of Mouse Line to Lineage Trace Gastrin-Expressing CellsUse of Axl Inhibitors as Anti-Fibrotic Compounds in Crohn’s DiseaseTargeted Infection Prevention Study Toolkit & Implementation GuideDopamine Receptor (3) Partial AgonistsSmall-Molecule Inhibitors of BET ProteinsSmall-Molecule Degraders of BET Bromodomain ProteinsImproving Outcomes After Allogeneic Stem Cell Transplantation

Optimizing Human Regulatory T-Cell Therapy Through Identification of Active miRNA/mRNA ComplexesSmall-Molecule Degraders of MDM2 ProteinSmall-Molecule Degraders of BET Bromodomain ProteinsSmall-Molecule Degraders of BET Bromodomain Proteins Containing DiazepineSmall-Molecule Degraders of BET Bromodomain Proteins Containing BenzodiazepineLong-Term Modeling of the Tumor Invasion Front Using a Three-Dimensional Fluidic SystemNephroseqHuman Lung Cells and Tissue for in Vitro StudyFiber Optic Guided Lung Delivery System - PhaethonIFI44L Methylation as a Diagnostic Marker for LupusAnti-Human CD13 Monoclonal Antibody

LAWNational Registry of Exonerations Mobile App

LIFE SCIENCES INSTITUTEHapalindole/Ambiguine Biogenesis is Mediated by a Cope Rear-Rangement, C-C Bond-Forming CascadeBaculovirus LIC VectorsUsing a Synthetic Loop Replacement Peptide to Inhibit the NF-kB Signaling PathwayInhibitors of Gram-Negative Bacterial Growth

MATERIALS SCIENCE & ENGINEERING

Immobilization Methods to Promote Purely Organic RTP in Amorphous Matrix via Covalent LinkingDirect Growth of Optoelectronic Devices on CMOS TechnologyGrowth and Maintenance of Ovarian Cancer Stem Cells in Three-Dimensional Spheroids Derived from Human Patient SamplesFemtosecond Laser-Induced Formation of Single Crystal Patterned Semiconductor SurfaceUltrafast Laser Irradiation to Alter the Efficiency of Catalytic Chemical Vapor DepositionDesigning Superhydrophobic Surfaces with Unprecedented Mechanical Durability and Their Utility in Drag Reduction During Turbulent FlowThin Film Ceramics and Cermets Processed Using Nanopowders of Controlled Compositions

MECHANICAL ENGINEERINGA Surface Tension Mediated Lyoprocessing Technique for Preservation of BiologicsA Technique to Estimate of Preservation Potential for Preservation FormulationsSegmented Cell Architecture for Solid State BatteriesSlurry Formulation for the Formation of Layers for Solid State BatteriesUse of Filtered Basis Functions to Compensate Servo-Induced Motion ErrorsFluidic Origami for Rapid Shape Morphing/Actuation and Mechanical Property TuningSubcutaneous Insertion DeviceElectrically Heated Catalyst for IC Engine Particulate ReductionSurface-Charge-Transfer Doping for Making Thin-Film Solar Cells and Photo-Response DevicesValve Timing Control for Reduced Emissions

Two-Dimensional Material-Based Field-Effect Transistor Sensors Scalable Fabrication of Multidimensional Nanopatterns via Sequential Combination of Continuous One-Dimensional Nanopatterning StrokesHigh Microchannel Volume Scaffolds for Nerve RepairLean Burn Internal Combustion Engine Flexure Augmented Roller BearingInductance Sensing Strength-Dexterity TestBattery State of Health Estimation Using Force in Incremental Capacity AnalysisThin-Film Piezoelectric Multi-Photon Endomicroscope for Vertical Cross-Sectional ImagingHybrid All-Wheel Drive System Having A Cross-Linked Dynamic ClutchHybrid All-Wheel Drive System Having An Aligned Dynamic ClutchHigh Rechargeable Magnesium Oxygen BatteryHigh Voltage Magnesium Oxygen BatteryMetal Oxygen BatteryMethod of Improved Performance in Lithium Metal ElectrodesDevice for Damping Vibrations In Multi-Stage TurbomachineryVariable-Stiffness Foot Prosthesis3D Printing Inside a Solid SubstrateAutomated Ultrasound Apparatus and Methods to Non-Invasively Monitor Fluid Responsiveness Multi-Chamber Sequentially Injecting Syringe Pneumatic Assistive Device for Walking and Running (Otto Boots)Device Features and Methods of Use for Delivery of Medical Fluids to Surrounding Tissue for Indwelling Devices within Tubular Biological StructuresCeramic Garnet Based MaterialDevelopment of Amnion-Like Tissue From Human Pluripotent Stem Cells

MEDICINAL CHEMISTRYDual c-Src/p38 Kinase InhibitorsSmall-Molecule Inhibitors Blocking Mitochondrial Synthesis through Elevation of ROS ProductionALDH Inhibitors for the Treatment of Chemotherapy-Resistant Epithelial Ovarian Cancer

MICHIGAN NANOTECHNOLOGY INSTITUTE

Multifunctional Drug MoleculesFormulation Comprising a Nanoemulsion, Another Adjuvant and an ImmunogenDODAC Nanoemulsion for Intramuscular, Intradermal or Subcutaneous Administration

MICROBIOLOGY & IMMUNOLOGYTreatment of Viral Respiratory InfectionEndoplasmic Reticulum Calcium as a Therapeutic Target for GangliosidosisImmunomodulatory and Anti-Infective Activity of Small Molecule DUB Inhibitors

MOLECULAR & INTEGRATIVE PHYSIOLOGY

Antibody to the Adapter Protein SH2B1Beta (Also Known as SH2-Bbeta or PSMbeta)Respiratory Rhythm Matrix, a Method for Sleep Apnea Detection

MOLECULAR CELLULAR DEVELOPMENTAL BIOLOGY

TRPML Plasmids and Stable Cell Lines

Compositions and Methods for Modifying a Predetermined Target Nucleic Acid Sequence

NAVAL ARCHITECTURE & MARINE ENGINEERING

Radar System for Environmental and Ship Motion ForecastingReal-Time Marine Radar Measurements of Ocean WavefieldsAn Adaptive Method for the Real-Time Forecasts of the Motions of Ships and Ocean PlatformsMethod for the Real-Time Forecasts of Dangerous Ocean Wave ConditionsInconspicuous Retroreflective Road Markings to Enable Infrastructure Detection for Autonomous Vehicles

NEUROLOGYMechanical CPAPAnti Mouth Venting DeviceAripiprazole as a Therapy for Machado-Joseph Disease or Spinocerebellar Ataxia Type 3 Neurodegeneration Related Reporter Constructs and AntibodiesSpeckle Tracking to Evaluate Diaphragmatic Motion with Ultrasound

NEUROSURGERYDrug Delivery Cavity ConvectionNeuroMap: Optimizing Cortical Mapping During Awake Craniotomy Brain Tumor ResectionsModified Human Spinal Stem Cells for the Formation of Inhibitory Synapses

NUCLEAR ENGINEERING & RADIOLOGICAL SCIENCES

Method for Removing Cyanotoxin from Water Using a Plasma DeviceMethod for Remote Quantitation of Unknown Radionuclide Distributions at Unknown DistancesA Rapid Adaptive Remote Hazardous Contaminant Characterization and Mitigation System

NURSINGDecision Matrix for Education and Competency EvaluationFacilitators Guide for Group Antenatal Care

OBSTETRICS & GYNECOLOGYLevator Defect Correction System - Method and DeviceSoftware to Assist Infertility Doctors and Their Patients in the Medication Management for Fertility Treatment Cycles

OPHTHALMOLOGYSmartphone-Based Retinal Imaging of Eye DiseaseSmartphone App for Low-Vision PatientsMethods for Post-Fabrication Modification of LensesGene Therapy Vector for Retinal DegenerationCharacterization of Cancerous LesionsAgents Affecting CD40L-Induced Inflammasome Activation and IL-1b, IL-18, MMP-9, and IL-1a Expression by Targeting CD40L ReceptorsThe Use of Magnetic Nanoparticles by Applying Magnetic Field in the Treatment of Intraocular TumorsThe Use of Photoacoustics to Image the Intraocular TumorsEnhancement of the Neuroprotective Potential of an Intrinsic Protective Pathway

OTHERDirect Current MotorPlastic Modified by Soy-Based RubberMicrofluidic Thrombus RemovalIntern Health Study Mobile App

Framework and Methods for Online Network Monitoring, Statistical Analysis and Forensics of Data StreamsGerman Language Video GameHealth Risk Assessment (HRA) 2016MCoverageWorkshop Series: Resource Utilization & Executing WorkAdolescent-Centered Environment Assessment ToolGoBlueNav App - Indoor Wayfinding AssistanceDeuterated PhScN and PhSCN Peptides as Highly Potent Invasion InhibitorsKidney Transplant Educational Mobile AppModified SyringePoke/Procedure Plan and Comfort MeasuresHands-On Lean Training

OTOLARYNGOLOGYSlc44a2 Knock Out MouseRepurposing of Antacids Medications for Oncological Applications: Cancer Prevention and Cancer TreatmentTegmen PlateUM-SCC-112-A Human Sinonasal Squamous Cell Carcinoma with an Activating EGFR MutationAdapted Functional Near Infrared Spectroscopy to Skull Openings to Optimize Capture of Central Neural Hemodynamic Responses 3D Printed Smashable TumorEar Implant for Reconstruction

PATHOLOGYHardware Assisted Microcontroller and Embedded System Active Intrusion DetectionSynthetic Lethal Targeting of TP53 Mutant CancersMarkov-Assisted Textural Classification HeuristicNon-Inflammatory Retinoids for the Treatment of Skin and Promyelocytic LeukemiaVector Invariant Pattern RecognitionAnatomic Pathology Tissue Block ImagerGross Examination Automation of Biopsy Specimens in the Anatomic Pathology LaboratoryOncogenic Role of THOR, a Conserved Cancer/Testis Long Noncoding RNABridged Bicyclic Inhibitors of Menin-MLL and Methods of UseSubstituted Inhibitors of Menin-MLL and Methods of UseASH1L Inhibitors and Methods of Treatment TherewithGeneration and Characterization of Ovgp1-iCreERT2 MiceIdentification and Use of Intestinal Resident Bacteria that Mediate Protection Against Enteric PathogensAlpha-Smooth Muscle Actin Promoter ConstructsInhibitors for Mixed Lineage Leukemia

PEDIATRICSConcussion Education Online Modules: Parent and Coach Bioresorbable Zinc-Aluminum Alloy Stents for Structural and Congenital Heart DiseaseChanging the Colors of the Gomo Clamp to Improve Patient SafetyMiGenE Family History Application

PHARMACOLOGYPrevention of Platelet Function and Thrombosis

Selective Inhibition of Cytochrome P450 17A1 (CYP17A1) Lyase Activity to Treat Prostate Cancer

PHARMACYHumanized PEPT1 Knockin MiceDrug Discovery to Inhibit PRC2 to Alter Epigenetics for Cancer TherapyIdentification of Non-Reported Bupropion Metabolites in Human PlasmaIMassFrag: Web Application-Assisted Mass Spectral Interpretation and Annotation for Drug Metabolite Identification Peripheral Neuropathy Mobile AppTargeted Absolute Quantitative Proteomics AssayCoated PLGA Implants for Long-Term Controlled Release of Antibody TherapeuticsModification of Cell Membrane Vesicles for Drug Delivery ApplicationsThe Use of Synthetic High Density Lipoproteins as Nanocarriers for Adjuvant Delivery

PHYSICAL MEDICINE & REHABILITATION

Digital Activity Importance MeasureSensory Awareness VestThe P300-Certainty Algorithm: Quantifying the Accuracy of Brain-Computer Interface SelectionsRemote Control for Oxygen Concentrators

PHYSICSSteerable THzComposite Reflective/Absorptive IR-Blocking Filters Embedded in Metamaterial Anti-Reflection Coated SiliconFrequency Comb Based Multidimensional Coherent Spectroscopy

PROFESSIONAL TRAININGHow Hospital Security Professionals Can Contribute Directly to Optimal Patient Outcomes

PSYCHIATRYSystems and Methods for the Identification of Pharmacoepigenomic Variants and Drug Epigenome NetworksStress GymLearn Psych PodcastSmartphone Application to Monitor Mood, Cognition and Functioning

PSYCHOLOGYIndividualized Self-Management Training for Adolescent Recipients of Transplantation (iSTART)

RADIATION ONCOLOGYDisclosure of Small Molecules that Selectively Degrade Mutant KRASTreatment of Cancer with DNAPK InhibitorsDisplay and Algorithm Tools for Incorporating Analysis of “Big Data” into Clinical PracticeQuantum-Based Clinical Decision Support SystemAn Inhibitor of the DNA Damage Response Pathway

RADIOLOGYBiodegradable Hydrogel for Tissue ExpansionCopper-Catalyzed Radiofluorination of Boronic AcidsClassification of Tissue Heterogeneity Based on Voxel Analysis of Registered Medical ImagesIn Vivo Photoacoustic Biopsy for Characterizing Intestinal Strictures in Crohn’s Disease

Treatment of KRAS and BRAF Mutated Cancers with Dual PI3K/EGFR Inhibitors in Combination with MAPK Pathway InhibitorsComputer-Aided Detection of Retained Surgical ItemsMethod and Apparatus for Removing MicrovesselsUltrasound-Guided Liver Biopsy Simulator3D Ultrasound/Photoacoustic Method for Measuring Brain Perfusion and Oxygen ConsumptionBifunctional MEK/PI3K Inhibitors for Therapeutic ApplicationLate Stage Copper Mediated Fluorination of Aryl StannanesSonographic Flap ManipulationWater in Perfluorocarbon Emulsions for Intrapulmonary Drug DeliveryStrain and Strain Rate Measurement for Local Lung Ventilation Estimation

SOFTWAREU-M Signature Generator ToolFindcare; Website Utility Connecting Uninsured Patients with Outpatient Medical Clinics that Can Take ThemOntology and Semantic Web-Based Adverse Event Case Reporting and Analysis SystemEpic Clarity - Oracle Data Extract Tool FlowMilk Room Inventory Database

SURGERYA Molecular Adjuvant for Cancer ImmunotherapyUse of Short-Term Gene Therapy to Decrease Host Susceptibility to Pneumonia, Sepsis and Acute Respiratory Distress Syndrome After Lung ContusionPrevention and Treatment of Traumatic Heterotopic Ossification and Fibrodysplasia Ossificans ProgressivaPressure Ulcer Prevention DeviceTargeted Gene Correction for Treatment of Fibrodysplasia Ossificans Progressiva Using the CRISPR/Cas9 Gene Editing Tool

SURGERY, CARDIACMethod of Creating Blood Vessels in Engineered and Native Tissues

SURGERY, GENERALMelanoma Ally3D Printed Microfluidic Artificial Lungs

SURGERY, ORTHOPAEDIC Physical Therapy Digital BandAutomated Assessment of the Severity of Knee ArthritisMobile App and Backend for Knee Replacement Peri-Operative Care

SURGERY, PLASTICAngiogenic Nanotechnologies for Bone Repair and RegenerationTreatment for Heterotopic Ossification Targeting Connective Tissue Pathologic Healing

SURGERY, UROLOGYBladder Cancer Videos

SURGERY, VASCULAREndovascular Skills for Trauma and Resuscitative Surgery - Curriculum

TRANSPORTATION RESEARCH INSTITUTE

Universal Countermeasure for Motion Sickness in VehiclesDevice and Task Independent Universal Countermeasure for Motion Sickness in Vehicles and Autonomous DrivingEnhanced Vehicle Cyber Security Through Improvements to Vehicle Bus Message Arbitration and AuthenticationSensor Based Parking Occupation Detection and Communication Network

TODAY’S INNOVATIONS FOR A BETTER TOMORROW
































































































































































































































































Since 2009, the Mentors-in-Residence program has provided the expertise of seasoned entrepreneurs for tech transfer activities and programs. Mentors-in- Residence (MiRs) are part-time employees working within U-M Tech Transfer to help assess new opportu-nities and provide hands-on assistance and mentoring for new startup projects. Their work has enhanced our ability to help launch exciting new startups based on U-M faculty inventions. The success of the MiR pro-gram has led to its use by other Michigan universities through the Tech Transfer Talent Network, funded by the Michigan Economic Development Corporation.

Here are three of our MiRs.MEERA VIJAN has over 30 years of experience in the advanced battery and flat-panel display industry. She was president of Ovonic Battery Company and was plant manager for A123 Systems, setting up the largest lithium-ion battery plant in the United States. As an MiR,

Meera has provided early startup projects with advice on competitive technology evaluation as well as market entry strategies based on her knowledge and contacts in the industry.

BRUCE AUERBACH has worked over 25 years in pharmaceutical drug discovery and early clinical development. He was co-founder and president of AlphaCore Pharma that was acquired by MedImmune. Prior to starting Alpha Core, he was a researcher at

Pfizer. Bruce applies his technical background along with his industry and venture experience to assess and model a wide variety of our life science proposals into high-potential licensing and new startup opportunities.

MIKE KLEIN is a serial CEO with over 20 years of experience developing, building and growing high tech, software, and IT com-panies. Mike launched his first startup, Steeplechase Software, and sold it to Schneider Automation in 2000. Mike led a turnaround for

a venture-backed network security software company, and then joined Online Tech as co-CEO in 2008, growing the company 500% over the next seven years. Mike has provided mentoring to a multitude of U-M networking, software, and data startup opportunities. Mike is now rotating off the MiR program to lead 2015 U-M startup Genomenon as its CEO.

Mentors-in-Residence Make an Impact

6

7

Arbor Medical InnovationsAutomated sensory assessment technologies

Freezer NannyEnvironmental monitoring platform for laboratory freezers, animal rooms and other research environments

Intelligent Vision SystemsIce detection technology for transportation systems

Iris MessagingHIPAA-compliant communication system for primary care physicians

KalyspoMicrofabricated surgical instrument tag and detection algorithms

MedigenixBioSmall molecules and biologics for treating pulmonary inflammation and fibrosis

MeliusFrontline quality measures, clinical intelligence, and targeted implementation guidance to improve perioperative care and outcomes

MovellusRe-architecting semiconductors for the cloud

MoxyTechTools for precision pain care, objective tracking, and analysis

PrenovoRisk assessment and prehabilitation for improved surgical outcomes

ResonantPlatform for rapid discovery of novel targets and anti-tumor antibodies

ViewPoint TherapeuticsNon-surgical treatment and prevention of cataracts and presbyopia

2016 Startup Class

8

Cataracts are an inevitable part of aging. Sooner or later, every adult who lives long enough will likely be a candidate for cataract surgery. Untreated cataracts are the leading cause of blindness—afflicting hundreds of millions of people. This is especially true in the developing world, where surgery is out of reach for most.

Cataracts occur when a protein called alpha-crystallin misfolds and then aggregates in the lens of the eye, creating a milky white opacity. Until now, surgery has been the only treatment option. That could change, thanks to a discovery by former U-M research scien-tists Jason Gestwicki, Ph.D., and Leah Makley, Ph.D., and the new business startup ViewPoint Therapeutics.

In 2011, Gestwicki and Makely discovered a small molecule called VP1-001 that could modulate the alpha-crystallin protein structure in the eye and cause mutant “misfolded” proteins to refold and return to their original, normal state. Subsequent experiments with mice and human cataract tissue demonstrated that this molecule, in the form of eye drops, could reverse both genetic and age-related forms of cataract disease. More recent research also suggests that VP1-001 may prevent and correct such common disorders as presby-opia, the age-related inability of the eye to focus.

In 2014, a group of venture capital investors led by biotech entrepreneur Ed Hurwitz launched ViewPoint Therapeutics to develop a VP1-001-based formula for human and possibly veterinary use. In April 2016, the company closed a $4M Series A financing.

As Hurwitz notes, “We are working to see if we can formulate the lead molecule in a way that is safe and effectively penetrates the lens. If that happens, we’re optimistic that VP1-001 will work in human and veterinary applications and that ViewPoint will be able to attract a corporate partner or additional investors to move this potentially transformational drug into the human trial phase.”

Eye Drops for Cataract Disease

With ViewPoint’s eye drop concentrate based on the VP1-001 small molecule, cataracts could become a thing of the past—and millions of people could be spared the tragedy of cataract-related blindness. In experiments to date, the VP1-001 has demonstrated its potential for reversing and preventing cataracts.

ViewPoint Therapeutics

9

National Advisory BoardThe U-M Tech Transfer National Advisory Board (NAB) provides advice and connections to enhance our impact and performance. Composed of industry, venture, government, university, and community leaders, the NAB has played a role in several influential initiatives including the creation of Ann Arbor SPARK, the Venture Center and Accelerator, and the Catalyst Talent Network.

The NAB’s latest initiative is the Tech Transfer Impact Fund with the goal of raising $10 million from donors and foundations to provide additional resources to assess, develop, and launch promising U-M technologies and startups. These additional resources will enhance and accelerate our work in transferring opportunities to our business and venture partners. For more information, contact [email protected].

National Advisory Board Members

Bill BrinkerhoffEntrepreneurAnn Arbor, MI

Wendell BrooksIntel CapitalSanta Clara, CA

Thomas BumolLilly Research Lab and Applied Molecular EvolutionSan Diego, CA

Jeff CarbeckDeloitte Consulting InnovationsBelmont, MA

John DennistonChairman, Shared-XMenlo Park, CA

Richard DouglasRetired, Genzyme Corp.Southborough, MA

Larry Freed2nd Stage PartnersAnn Arbor, MI

Serena GloverAngel Investor, EntrepreneurRedmond, WA

Kenneth A. GrahamInverness Graham InvestmentsNewtown Square, PA

Bill HarringtonOsage University PartnersPhiladelphia, PA

Paul KrutkoAnn Arbor SPARKAnn Arbor, MI

Thomas PorterTrillium VenturesAnn Arbor, MI

Chris RizikRenaissance Venture CapitalAnn Arbor, MI

Maria ThompsonArsenal Venture PartnersAnn Arbor, MI

Jack TurnerMIT, Technology Licensing OfficeCambridge, MA

Tom WashingSequel Venture PartnersBoulder, CO

Teri WilleyBusiness Development & Tech TransferCold Spring Harbor LaboratoryCold Spring Harbor, NY

10

Partners assist us in our efforts to commercialize discoveries from U-M research, contributing to their value and enhancing the climate for innovation and entrepreneurship.

ANN ARBOR SPARK, our regional economic develop-ment partner, provides business attraction, talent development and early-stage funding programs that attract business partners and provide critical resources for our startups. The University and SPARK work closely on strategic economic development initiatives for our region.

The statewide MICHIGAN ECONOMIC DEVELOPMENT

CORPORATION (MEDC) provides generous financial support for a variety of programs. MEDC resources have enabled gap funds, translational research funds, talent programs, business engagement, and pre- seed, angel, and venture capital support.

Enhancing the climate for faculty innovation and entrepreneurship and providing translational research funds for promising projects are partnerships among many University organizations. Some examples include the CENTER FOR ENTREPRENEURSHIP in the

College of Engineering, FAST FORWARD MEDICAL

INNOVATION in the Medical School, the ZELL-LURIE

INSTITUTE in the Ross School of Business, and the CENTER FOR INNOVATION AND SOCIAL

ENTREPRENEURSHIP in the School of Public Health.

U-M Tech Transfer benefits from a close relationship with several venture funding organizations. The

MICHIGAN VENTURE CAPITAL ASSOCIATION develops, grows, and sustains a vibrant venture capital community in Michigan. The U-M MINTS program, part of the U-M Investment Office, provides venture funding for U-M startups with other qualified venture partners. U-M is also one of the original university partners of OSAGE UNIVERSITY PARTNERS, which invest exclusively in university startups.

Our U-M BUSINESS ENGAGEMENT CENTER and partner corporate relations units in the College of Engineering and Medical School work with us to enhance the University’s engagement with industry and other organizations. Together we connect University opportunities to businesses that can benefit from sponsored research, inventions, regional initiatives, student talent, and more.

Partnerships

Contact Us! The U-M Tech Transfer team is ready to introduce you to your next big opportunity.

Contact us at 734.763.0614, [email protected] or www.techtransfer.umich.edu.

U-M Tech Transfer Team Row 1 (left to right): Debbie Watkins, Jack Miner, Mutsumi YoshidaRow 2: Rick Brandon, Barbara Koenig, Diane Rice, Diane GiannolaRow 3: Steve Maser, Lisa JohnsonRow 4: Luana King, Laura Charlick, Tara HartmanRow 5: Jessica Soulliere, Ken Nisbet, Dave ReppRow 6: Carmen Atkins, Jena Ault, Jodie Richardson, Ed Pagani, Mark MaynardRow 7: Joohee Kim, Drew Bennett, Greg ChoiniereRow 8: Bryce Pilz, Keith Hughes, Chris Fick, Tiefei DongNot pictured: Brian Copple, Dennis Linder, Mike Psarouthakis

D

EDITOR

Linda W. Fitzgerald

CONTRIBUTING EDITOR

Mark Maynard

PHOTOGRAPHY

Leisa Thompson Doug Coombe Michigan Photography

DESIGN + PRODUCTION

James Reitz Michigan Creative

PROJECT MANAGERS

Mark Maynard Carly Sorscher Michigan Creative

THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Michael J. Behm, Grand BlancMark J. Bernstein, Ann ArborLaurence B. Deitch, Bloomfield HillsShauna Ryder Diggs, Grosse PointeDenise Ilitch, Bingham FarmsAndrea Fischer Newman, Ann Arbor Andrew C. Richner, Grosse Pointe Park Katherine E. White, Ann Arbor Mark S. Schlissel, ex officio

NONDISCRIMINATION POLICY STATEMENTThe University of Michigan, as an equal opportunity/affirmative action employer, complies with all applica-ble federal and state laws regarding nondiscrimination and affirmative action. The University of Michigan is committed to a policy of equal opportunity for all persons and does not discriminate on the basis of race, color, national origin, age, marital status, sex, sexual orientation, gender identity, gender expression, disability, religion, height, weight, or veteran status in employment, educational programs and activities, and admissions. Inquiries or complaints may be addressed to the Senior Director for Institutional Equity, and Title IX/Section 504/ADA Coordinator, Office for Institutional Equity, 2072 Administrative Services Building, Ann Arbor, Michigan 48109-1432, 734-763-0235, TTY 734-647-1388, [email protected]. For other University of Michigan information call 734-764-1817.

MC170034

U-M Tech Transfer 1600 Huron Parkway, 2nd FloorAnn Arbor, MI 48109-2590 tel 734.763.0614 [email protected] www.techtransfer.umich.edu

Documents

2016 U-M Tech Transfer Impact Report · ing with the prestigious Rice Business Plan Competition in Houston, where they captured a $50,000 second- ... ing preliminary work on an advanced