20,000 GENES IN HUMAN GENOME; WHAT WOULD HAPPEN IF ALL THESE GENES WERE EXPRESSED IN EVERY CELL IN YOUR BODY?

WHAT WOULD HAPPEN IF THEY WERE EXPRESSED IN THE WRONG CELLS?

WARM-UP # 5 1/13/2015

Why is control of gene expression important?

Antennapedia

How do cells know which genes to use?98% of human genome does NOT code for

proteins!RNA polymerase – enzyme that produces

mRNA

Promoter Region of DNA that begins transcription

TRANSCRIPTION FACTORSo Proteins that control transcription

o Bind to enhancer DNA

o Always present in cell, but most likely have to be activated before they will bind to DNA

Transcription Factors• Essential for the transcription of all

protein-coding genes• Can either repress or enhance

transcription