Insulin Resistance Hyperglycemia Diabetes Type 2 Blood Osmolality Blood viscosity Blood sugar exceeds renal threshold Glucose cannot enter cell Gluconeogenesis activation Fluid shifting from intracellular to extracellular Intracellular DHN Thirst Sensation Polydipsia Blood Flow Favors bacterial growth Tissue Perfusion Infection Wound Healing Gangrene Formation Amputation Glycosuria Osmotic Diuresis Urine Output Polyuria Cellular Starvation Sensation of hunger Polyphagia Lipolysis Accumulation of by product Fatty Acid Ketones Atherosclerosis Micropathy Metabolic acidosis CHON breakdown Muscle Wasting and poor wound healing Toxic to Brain tissue Acetone Breath Ketonuria Diabetic Ketoacidosis Macropathy CVA, MI, PVD Retinopathy Nephropathy Loss of vision Blindness ESRD Neuropathy Loss of Sensation Tingling/numbness Weakness Diabetes Mellitus Type 2
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