Workshop No. 257

FLUIDIZED BED AS MULTIPURPOSE PROCESS21 – 23 January 2020

WHY PARTICIPATING?

This workshop on fluidized bed technology is a perfect combination of theory, hands-on training and demonstrations.

The workshop provides the basics of drying, granulating, coating and pelletizing and outlines their applications in the powder processing industry.

This workshop is the perfect investment for those who wish to acquire knowledge of fluidized bed technology.

WHO SHOULD PARTICIPATE?

Typically, operators and researchers from the pharmaceutical and related industries will get the most out of this workshop.

However, the workshop is also perfectly suitable for those who want a detailed overview of fluidized bed technology in a short space of time.

PROGRAM

TUESDAY, 21 JANUARY 202011:30 Transfer from hotel to TTC

12:00 Reception and registration, snack buffet

12:30 Introduction. Andreas Gottschalk

12:45 Basic principles of fluidized bed processing Focussing on the advantages and disadvantages of fluidization. Also covering characteristics of the fluidized bed, mixing, and segregation during the fluidization process. Agba Salman

13:30 Fluidized bed processing: the fluidized bed drying process. Outlining the fundamentals of the fluidized bed drying process with special emphasis on the heat transfer process. Also discussing the influence of various process variables on the drying time and fluidized bed temperature. Agba Salman

14:30 Coffee break

15:00 Fluidized bed processing: the fluidized bed granulation process. Identifying how process parameters impact on the granulation process in fluidized bed granulation. Various results from literature are compared and discussed. Agba Salman

16:00 Preparation of multiparticulates using fluidized bed - principles of drug layering and functional coating. Covering formulation and process variables influencing drug layering and coating at different scales. Also addressing post coating processes (e.g. curing) and their influence on drug release and stability. Finally introducing an “assembly kit” for small scale development of multilayer pellets. Karl-Gerhard Wagner

16:45 PAT case study 1: Inline moisture measurement by microwave technology. Udo Schlemm

17:30 Transfer to hotel

19:00 Transfer to Workshop dinner

19:30 Visit to Classic Car Museum Pantheon, Basel and Workshop Dinner

WEDNESDAY, 22 JANURARY 202008:00 Transfer from hotel to TTC

08:30 Spray systems for fluidized bed applications. Looking closer at the most relevant spray technologies for pharmaceutical applications. Discussing the impact of an adequate spray system function on product and process quality. Norbert Pöllinger

09:15 Scale-up of fluid bed processes. Introduction to scientifically and empirically based approaches, allowing for successful scale-up from lab to production volumes. Annette Grave

10:00 Coffee break

10:30 Continuous fluidized bed processing. Comparing batch and continuous operations and describing their various process options. Giving an overview on state-of-the-art equipment for continuous fluidized bed processing. Katja Oppermann

11:15 Hands-on demonstration - a close look at traditional and innovative fluidized bed processes (GMP/non-GMP) – MicroPx Technology- how to produce high drug loaded micropellets. Katja Oppermann

12:00 PAT case study 2: Inline particle size monitoring by spatial filter technology (SFT). Stefan Dietrich

12:30 Lunch

13:30 From lab to production scale - a look at equipment for the real world. Discovering the full range of state-of-the-art fluidized beds units from grams to tons. Sales TeamTransfer to Innovation Center

14:15 Hands-on demonstration - a close look at traditional and innovative fluidized bed processes - Part 1 - 3– MODCOS Wet Granulation + Drying - a modular solution approach for continuous manufacturing– CPS Technology - the new fluidized bed rotor process for direct pelletisation– Spray Nozzles - Considerations for a high tech tool Team Innovation Center

15:00 Coffee brack

15:30 Hands-on demonstration - a close look at traditional and innovative fluidized bed processes - Part 4 - 6– Twin-Pro or Fluidized bed granulation - applying a new tangential spraying technology, online process monitoring with PARSUM particle size sensor– Wurster Bottom Spray - fluidized bed pellet coating - modern applications with an established technology– PharmaLab - Continuous Spray Granulation with integrated particle screeningTeam Innovation Center

17:00 Transfer to hotel

18:45 Transfer to Evening Event Location

19:00 “Hands-on underground workshop“ followed by Workshop Dinner

THURSDAY, 23 JANUARY 202008:00 Check-out from hotel and transfer to TTC

08:30 Powder Layering - a real high speed processOutlining and discussing findings from a process to quickly gain particle mass and size. Norbert Pöllinger

09:15 Process optimization considering QbD and using DoE - the basis for successful scale-up. Process optimization is a pre-re-quisite for successful scale-up and process validation. Presen-ting real-life examples of how to apply Quality by Design and Design of Experiments. Thorsten Cech

10:00 Coffee break

10:20 Excipients for fluidized bed processes. Providing an insight into the common excipients for the various fluidized bed processes such as granulation, pelletization and coating and their effects on the final product. Jörg Brunemann

11:00 Semi- and fully automatic cleaning of fluidized bed installations applying WIP and CIP. Exploring how to best use cleaning systems in the latest pharmaceutical processes - illustrated on fluidized bed systems. Axel Schiffmann

11:45 Hands-on demonstration - a close look at traditional and innovative fluidized bed processes, Part 7CIP-it! Demonstration of Hands-off cleaning of a Fluid Bed Processing Unit - real CIP!

12:30 Summary and snack buffet

13:00 Transfer to Basel, German Railway Station (Badischer Bahnhof), Swiss Railway Station (SBB) and EuroAirport

SPEAKERS

Dr. Jörg Brunemann HARKE Pharma GmbH, GermanyThorsten Cech BASF SE, GermanyStefan Dietrich Parsum GmbH, GermanyDr. Annette Grave Glatt Pharmaceutical Services GmbH & Co. KGKatja Oppermann Glatt Ingenieurtechnik GmbH, GermanyDr. Norbert Pöllinger Glatt Pharmaceutical Services GmbH & Co. KGProf. Dr. Agba Salman University of Sheffield, United KingdomDr. Axel Schiffmann F. Hoffmann-La Roche AG , SwitzerlandUdo Schlemm TEWS Elektronik GmbH & Co. KG, Germany Prof. Dr. Gerhard Wagner Universität Bonn, Germany

MODERATION

Andreas Gottschalk, Technology Training Center, Germany

DETAILS >> The participation fee is € 1.590,– (exclusive of VAT).

>> This fee includes participation, accompanying course notes, daytime catering and dinner. Any other expenses are to be borne by the attendee.

>> Free attendance granted to a limited number of students.

>> Participation is limited. Registrations will be confirmed on a first come first serve basis.

>> Courses taking place in Germany are subject to Value Added Tax (VAT).

>> Each participant will receive a certificate of attendance at the end of the course.

The capacity of the workshop and its number of attendees is limited. Hence, early registration is highly recommended, to secure your participation of the workshop.

ORGANIZATON AND LOCATION

TTC - Technology Training CenterRegina Bernstein / Andreas Gottschalk / Bianca NowakWerner-Glatt-Straße 1, 79589 Binzen, GermanyTel +49 7621 - 664 308Fax +49 7621 - 664 91 308E-mail ttc@ttc-binzen.de

For further information or online registration please visit us on

www.ttc-binzen.de

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