Author Index

AAbbott, N.J., 198Abdallah, B., 195Abdellauoi, K.S., 324Abdullah, S., 174Abdullah, T.H., 264Abe, T., 322Abedi, M.R., 172Aberle, A.M., 190Abes, S., 171Abordo-Adesida, E., 189Aboubakar, M., 118Abribat, T., 272Abuchowski, A., 4, 11, 12Abulrob, A., 205Acevedo, O., 276Aceves, J., 206Acharya, S., 324Achenbach, J.C., 187Adak, A.K., 343Adam, M., 55Adami, R.C., 192Adams, M.L., 5, 12Adamson, C., 186Aderem, A., 317Agarwal, R.G., 321Ageyama, N., 169Agudelo, C.A., 131, 136, 141Ahlemeyer, B., 19Ahluwalia, A., 245Ahmad, I., 169Ahmad, M.U., 169Ahmad, S., 188Ahmed, A., 188Ahmed, F., 14, 15, 342Ahmed, Z., 261

Ahn, K., 227Ahn, W.S., 171Aida, T., 12Ainsley, C., 243Aitken, R.J., 90Ajith, T., 264Akaike, T., 6, 200Akari, H., 169Akashi, Y., 262Akbuga, J., 197Akiba, M., 263Akinc, A., 169, 192Akita, H., 165Akiyoshi, K., 12, 69Akizawa, T., 261, 263Akli, S., 189Aksimentiev, A., 281, 282Aktas, Y., 204Alajajian, B., 203Alakhov, V., 4, 12, 13Alakhova, D.Y., 317, 318Alarcon, C.D.H., 340Alberda van Ekenstein, G., 333Alberga, A., 129Alberti, K.G.M.M., 128Alblas, J., 227, 233, 244, 245Alessandrini, J.L., 98Alestrom, P., 202Alexander, C., 340Alexander, I., 172Alexander, M.R., 245Alexandridis, P., 56, 281Alhaique, F., 227, 323Ali, S., 226, 241, 242Ali, S.M., 169Al-Jamal, K.T., 197

J. Coelho (ed.), Drug Delivery Systems: Advanced Technologies PotentiallyApplicable in Personalised Treatment, Advances in Predictive, Preventiveand Personalised Medicine 4, DOI 10.1007/978-94-007-6010-3,© Springer ScienceCBusiness Media Dordrecht 2013

359

360 Author Index

Alken, P., 256Allémann, E., 115Allen, C., 12, 330, 332, 334, 340, 341Allen, E.D., 189Allen, T., 88, 101Almeida, H.A., 226, 227, 232, 239Almofti, A., 191Almofti, M.R., 191Alonso, M.J., 75, 196, 204, 316, 323Alpar, H.O., 196, 197Alpert, E., 186Alsahli, M., 128Alsberg, E., 322, 323Alton, E.W., 173, 174Alvarez-Lorenzo, C., 59, 61Alvarez-Maya, I., 204, 206Alwarawrah, M., 284Amadio, S., 189Amalvy, J.I., 239Amaral, I.F., 195Amédée, J., 247, 248Amendola, M., 189Amidon, G.L., 10, 118, 200Amiji, M.M., 5Aminabhavi, T.M., 116, 323, 324An, Y., 332, 339Ananthapadmanabhan, K.P., 60, 64Anantharamaiah, G.M., 18Anaya-Martinez, V., 206Andereggen, E., 131Andersen, M.O., 197Anderson, B.D., 281, 284Anderson, D.G., 157, 169, 197, 274Anderson, E.M., 324Anderson, J., 308Anderson, N.N., 169Anderson, P.N., 189Andersson, D., 46Anderton, B.H., 204, 207Ando, T., 326André, J.C., 233Andrews, E., 200Andrieux, K., 204Andrus, G.M., 262Anesti, A.M., 189Anguita-Alonso, P., 324Anikina, E., 19, 21Animati, F., 281Anklesaria, P., 173, 175Annapragada, A., 306Annett, G., 172Anseth, K.S., 136, 143, 146, 234Antonietti, M., 60, 103, 330, 332, 333Antoniw, P., 11

Antunes, F.E., 56, 60, 62, 63, 70Anwar, J., 284Anzai, J., 229Aoyagi, T., 13Aoyama, Y., 76Apfel, S.C., 186Apostolidis, N.S., 259Apparailly, F., 170Appell, J., 46, 47Aprahamian, M., 117Arai, N., 261Arakawa, T., 104Arap, W., 319, 320Araujo, P.S., 165Araujo-Andrade, C., 291Arbit, E., 110, 113, 114Arcamone, F., 281Arcaute, K., 233, 236, 239Arehart, S.V., 327Arendt, G., 186Arfsten, A., 207Argazzi, R., 103Arias-Montaño, J.A., 204, 206Arifin, D.Y., 296, 299–301Arkhipov, A., 281, 282Arkhipova, V., 118Armes, S.P., 5, 15, 18, 334, 336, 338, 339,

342, 344Armitage, D., 5Armstrong, A., 13Aronsohn, A.I., 166Arora, S., 164Artursson, P., 120, 196, 197, 202Arzumanov, A., 187Asada, H., 167Asai, K., 262Asbach, C., 90Ashush, H., 186Asuni, A.A., 204, 207Atassi, G., 262Atkins, M.B., 173, 175Attwood, D., 119Audebert, R., 60Augst, A.D., 323August, J.T., 196Aurdal, L., 306Aurias, A., 172Auyeung, R., 236Avadi, M.R., 120Avarbock, M.R., 16Averick, S.E., 346Avula, B., 262Axelsson, A., 301Ayer, D.E., 261

Author Index 361

Ayer, J., 186Azadi, A., 196, 228Azarmi, S., 325Azhdarinia, A., 323Azzam, T., 333

BBaba, Y., 191Babiarz, J., 186Babu, V.R., 116, 324Bacáková, M., 247, 248Bader, H., 12Baek, J.U., 194Baggett, B.K., 261, 263Bähr, M., 190Bailey, C.J., 129Bailey, L., 5Baird, A., 204, 207Bajpai, A.K., 316, 335–337Bajpai, J., 335–337Baker, J.R. Jr., 193Bakkour, N., 170Bakowsky, U., 195Balaban, N., 324Balamurugan, A.N., 141, 146Balasubramaniam, R.P., 190Baldeschwieler, J.D., 199Baldwin, A.D., 322, 323Baldwin, T., 18Balfour, R., 173, 174Ballinge, W.F., 130Bally, M.B., 161Bandyopadhyay, S., 95, 284Banerjee, R., 322Bannon, M.J., 206Bansal, K., 324Baranovsky, V.Y., 61Barati, S., 204, 207Barba, A.A., 324Barbosa, M.A., 195, 204, 208Barcia, C., 189Barcza, A., 22Bardi, G., 197Bareford, L.M., 318Bareille, R., 247, 248Barenholz, Y., 161Barkats, M., 189Barker, P.A., 207Barman, B.N., 103, 104Barnhart, L.E., 201Baron, P.A., 88Barr, J., 324

Barrand, M.A., 19, 21Barreiro-Iglesias, R., 59, 61Barreiros, F.M., 88Barrett, L.B., 193, 204, 207Barrias, C.C., 196Barron, J.A., 245–249Barron-Moreno, F., 204, 206Barshes, N.R., 141, 143Barsky, L.W., 172Bartanusz, V., 203Barth, T.J., 282Barthelmes, J., 118Bartholomeusz, C., 173, 175Bartlett, J.S., 189Bártolo, P.J.S., 226–228, 230, 232, 233,

239, 243Barton, S.W., 19, 20Baselt, R.C., 262Bashir, R., 234, 235, 237, 238, 318Basit, A.W., 115Baslé, M.F., 324Bassereau, P., 46Basta, G., 136, 141Bastian, J., 172Batchelor, D., 95Batelaan, J.G., 55Bates, F.S., 15, 342Batista, C.M.S.G., 291Batistatou, A.K., 186Batrakova, E., 12, 13Batshaw, M.L., 172Battaglia, G., 15, 55Baudyš, M., 9, 12Bauer, M., 322, 324Baum, B.J., 172Bauman, J., 188Bausch, J., 11Bayat, A., 120Baykara, M., 324Bazzani, R.P., 174Beanland, R., 91Beatty, B., 10Beaumont, E., 196Beberg, A.L., 308Becker, M., 259Beckett, R., 104Bedikian, A.Y., 173, 175Behr, J.P., 14, 18, 166, 190, 194, 195, 199,

201, 202Beil, J., 77Beisner, J., 171Beja, A.M.M., 286, 290Belguise-Valladier, P., 166, 202Béliveau, R., 204, 205

362 Author Index

Bellance, S., 247, 248Bellocq, N.C., 195Bencherif, S.A., 334, 343Benderdour, M., 196Benfenati, F., 207Beningo, K.A., 319, 320Benito, S.M., 15Benito-Lopez, F., 58Bennett, C.F., 191Bennett, M.J., 190Benoist, C., 195Benoit, J.P., 118, 119Benson, D.E., 292Benvegnu, T., 158–160, 164Berendzen, J., 292Bergen, J.M., 9Berger, M., 11Bergfeldt, K., 61, 62, 65Berggard, T., 75Beris, A.E., 186Berliner, E.M., 262Bermudez, H., 15Berndt, I., 59Berne, B.J., 95, 98Bernkop-Schnürch, A., 118Berrard, S., 16Berry, M., 204, 207Berthold, A., 196Bertin, S.L., 9, 168Bertram, J.S., 256Bertrand, Y., 204, 205Bertsch, A., 233Besenbacher, F., 197Besnard, M., 118Bessodes, M., 164, 199Besterman, J.M., 8Bettinger, T., 196Beveridge, D.L., 283Bevers, M.W., 173, 175Bexiga, M.G., 77Bhaduri, S., 243Bhalgat, M.K., 193Bhanu, S., 316, 335–337Bhaskar, S., 320Bhatia, S.N., 236, 240Bhatia, V., 189Bhattacharya, S., 191Bhattarai, N., 323Bhonde, R.R., 135Bianchini, P., 322Bianco, A., 197Bickel, U., 194Bieber, T., 202Bielinska, A.U., 193

Biffi, A., 189Bijsterbosch, B.H., 55Bilbao, G., 143Billingham, N.C., 336, 338, 339, 342, 344Binnig, G., 93Biondi, M., 228Birnsteil, M.L., 16Birnstiel, M.L., 13, 16, 17Bivigou-Koumba, A.M., 333Bjorklund, T., 189Black, F.E., 20Black, K.L., 204Blaese, R.M., 172Blanchard, J.C., 206Blanchard, K., 169Blanche, F., 202Blatter, M., 262Bleackley, R.C., 147Blezinger, P., 2Blit, P.H., 321Blobel, G., 10Blokhin, A.V., 9Blomer, U., 189Bluestone, J.A., 129Boado, R.J., 163, 203, 204Bock, J., 61Bockstaller, M.R., 330, 333Boddington, S., 164Bode, J., 70Boden, D., 170Boeckle, S., 195Boer, G.J., 189Boerakker, M.J., 15Boerner, H.G., 328, 346Boese, Q., 188Boey, F.Y.C., 301Bogner, E., 119Boiarski, A., 135Boland, T., 243, 245, 246Bolger, P.M., 262Bolli, G.B., 112, 113Bombardieri, E., 256Bombelli, F.B., 75Bonaguro, R., 189Bonassar, L.J., 243, 246Bonner-Weir, S., 140Bono, F., 202Borchard, G., 120, 196, 285, 286Borden, K.A., 20Bordenave, L., 247, 248Bordens, R., 11Border, R., 160, 161, 190Bordignon, C., 189Borenstein, J., 226

Author Index 363

Bories-Azeau, X., 338Borner, H.G., 346Bornstein, P., 7, 21Borowiak, M., 131Bortzov, F., 190Bosio, C.M., 168Bostock, T., 45, 46Bottoni, P., 256, 259Boucher, R.C., 199Boulis, N.M., 189, 208Bouneaud, C., 172Bourdoulous, S., 203Bousguet, A., 338Boussif, O., 14, 18, 194Bousso, P., 172Boutet, V., 191Bowen, P., 88, 89, 103Bowen, T., 172Bowie, K.M., 131Bowman, K., 169Bowman, V.D., 18Boyd, A.C., 166, 174Boyd, R.D., 94Boyer, C., 328Boyle, M.P., 118Bracho-Blanchet, E., 140, 141Bradley, B., 136, 143Brambilla, E., 199Brambilla, R., 189Bramlage, B., 169Brampton, M., 4, 13Branco, M.C., 339, 340Branden, L.J., 166, 203Brandenberger, H., 136Brandhorst, D., 146Brandhorst, H., 146Branham, D.L., 173, 175Brannan, A., 15, 342Brash, J.L., 321Bratzel, M., 135Braun, A., 186Braunecker, W.A., 325Breese, G.R., 189Breeze, M., 283Breier, G., 146Breitenbach, A., 118Brendel, M.D., 140, 146Brenner, B.M., 5Bretzel, R.G., 138, 140, 146Brewer, J., 13Brigger, I., 324Briggs, R., 95Bright, C., 14, 19, 20Bright, N.A., 9

Brinster, R.L., 16Brisson, C., 199Brochard-Wyart, F., 15Brodsky, M., 94Bronson, R.T., 170Bronstein, L., 333Brooks, A.I., 189Brooks, C.L., 283Brooks, J., 172Brouwer, P., 95Brown, K.C., 21Brown, M.D., 190, 192–194Brown, W., 95Browning, J., 173, 174Brownlee, M., 128Brownlie, A., 192, 193Broz, P., 15Brulet, P., 208Brunda, M.J., 11Brunetti, P., 136, 141Brunner, S., 10, 194, 200Brunovskis, P., 10Bruns, C.M., 308Brutkiewicz, R.R., 263Bryant, J., 163, 323Bryant, J.L., 191Bryant, S.J., 234Bryers, J.D., 324Buchmeiser, M.R., 343Budd, G.C., 115Budker, V., 190Bühler, L., 131Bui, T., 204, 206Buiting, A.M.F., 5Bulmus, V., 11, 19, 20, 328Bumcrot, D., 169Bunjes, H., 323Bunker, A., 293Buratta, M., 207Burdick, J.A., 338Burger, P., 15Burotto, F., 172Burschkies, K., 262Burt, H.M., 197Burtles, S., 3Bussy, C., 197Butler, D., 169Butun, V., 338Byk, G., 202Bylaska, E., 274, 307Byrne, J.D., 317, 318Byrne, R., 58Bysell, H., 69Byun, J., 338

364 Author Index

CCabane, B., 67Cable, H.C., 8, 199Cabric, S., 141Cabrita, A.S., 168Cafiero, M., 274, 275Cai, C., 12, 13Cai, J., 245Cai, S., 15, 320Cai, X., 197Cai, Y., 338Caillaud, C., 189Cairns, R.A., 259Calabrese, G., 141Calafiore, R., 136, 138, 141Calcutt, N.A., 186Calderón, M., 340, 343Caldorera-Moore, M., 229Caldwell, J.W., 283Callegari, J., 16Calogeropoulou, T., 342Calvo, P., 75, 196Cambre, J.N., 334, 335, 338Cameron, G., 257Cameron, N.R., 321Cammas-Marion, S., 164Campanella, O., 282Campbell, A.M., 77, 207Campbell, I.G., 164Campbell, J., 9, 20Campbell, S., 13Canaple, L., 141Canelas, D.A., 316, 319–321Canton, I., 15Cantos, C., 170Cao, A., 95Capan, Y., 204Cappello, F., 256Capranico, G., 281Carbonaro, D., 169, 172Carbone, G.M., 188Cardoso, A.L., 163, 164, 166, 170, 204Carey, M., 173, 175Carino, G.P., 113Carithers, R., 11Carl, D., 261Carlier, F., 172Carlsson, P.O., 146Carlsson, T., 189Carlstedt, J., 70Carmoy, N., 164Carothers, A.D., 173Carotta, S., 10, 200Carr, B., 99

Carraway, R., 206Carter, J., 264Cartlidge, S.A., 8Carvajal, J., 204, 208Carvalho, M.L., 259Carvalho, R.A., 116, 121, 286, 290, 291Casanova, J.L., 172Case, D.a., 283Casey, D.G., 170Cashman, S.M., 189Cassidy, J., 3, 11Castaigne, J.P., 204, 205Castanares, M., 208Castel, M.N., 206Castle, P.E., 201Castranova, V., 77Castro, M.G., 189Catapano, C.V., 188Catros, S., 247, 248Cattaneo, E., 186Cavazzana-Calvo, M., 172, 173Cedervall, T., 74, 75Celik, H.H., 204Censi, R., 227Certain, S., 172Chabassier, P., 248Chabre, Y.M., 194Chadda, R., 318Chadwick, S.L., 173, 174Chai, J.K., 323Chai, Z.F., 75Chaikof, E.L., 131, 132, 135, 136, 140–145Chalasani, K.B., 119Chamberlain, S., 204, 208Champion, J.A., 317, 319Chan, C.K., 166, 202Chan, C.Y., 200Chan, E., 264Chan, F.H., 261Chan, F.K., 256Chan, H.W., 14, 158, 190, 191Chan, J.M., 2Chan, M., 174Chan, R., 172Chan, S.W., 264Chan, V., 234, 237Chan, W.C.W., 78Chan, Y.S., 264Chance, R.E., 118Chang, E.H., 164Chang, H.T., 321Chang, I., 18, 20Chang, J.Y., 175Chang, K-H., 226, 227

Author Index 365

Chang, P.L., 131Chao, Y.L., 77Chapman, A.P., 11Chappard, D., 324Charalabopoulos, K.A., 186Charisse, K., 169Charles, A., 163Charleux, B., 325, 326Charneau, P., 203Charo, I.F., 207Chase, T.A., 262Chaudhary, A., 324Chauvierre, C., 324Chavez-Reyes, A., 169Che, C., 204, 205Chécot, F., 329–331, 334, 343Chellat, F., 196Chen, C.K., 321Chen, C.T., 119Chen, C.W., 190Chen, C.Y., 18, 21, 75, 338Chen, D.J., 71Chen, E., 323Chen, G., 12Chen, H.L., 18, 144, 145, 166, 195, 245, 345Chen, H.M., 77Chen, J., 166, 194, 195, 197, 204, 205Chen, J.C., 141Chen, J.L., 261Chen, J.-P., 226, 227Chen, K.J., 116Chen, L.J., 168Chen, L.L., 208Chen, L.M., 262Chen, M.C., 4, 116Chen, R., 16, 19, 21, 22Chen, R.J., 343Chen, R.R., 144, 146Chen, S., 239, 242Chen, T., 12, 13Chen, X., 227Chen, X.C., 168, 262Chen, X.G., 323, 332, 339Chen, Y., 169, 208, 262Chen, Y.L., 323Chen, Z., 75, 164Cheng, A.S., 256Cheng, H., 200, 256Cheng, J., 246, 345Cheng, L.N., 264Cheng, S.H., 160, 173, 174Cheng, W.P., 119, 120Cheng, Y., 322Cherng, J.Y., 18, 19

Chernik, G.G., 45Chernyshev, A.E., 263Cheshire, R.M., 264Chess, R.B., 4, 5, 12Cheung, C.Y., 7, 14, 19–21, 146Cheval, N., 333Chi, J.T., 261Chiang, C.H., 190Chiang, M.Y., 191Chiche, J., 261Chicheportiche, D., 141Chichkov, B., 236Chick, W.L., 132Chiellini, E., 322, 324Chiellini, F., 322, 324Chien, P.Y., 169Chilkoti, A., 20Chilukuri, D.M., 49Chin, K., 13Chin, L.T., 77Chiorini, J.A., 189Chipman, P.R., 18Chirmule, N., 172Chithrani, B.D., 78Chiu, S.J., 164Chiuman, W., 187Chmelka, B.F., 60Chmielewski, J.A., 199Cho, C.-S., 12, 61, 200Cho, C.W., 200Cho, D.-W., 234, 235Cho, K., 164Cho, M.H., 200Cho, M.Y., 195Cho, S.H., 336Cho, Y.S., 200Choe, Y.H., 11Choi, H.G., 194, 195Choi, H.-K., 61Choi, J.S., 194Choi, K.L., 160Choi, Y., 22Choi, Y.H., 193Choi, Y.J., 200Chono, S., 169Choong, P.F., 192Chou, S.H., 77, 204, 208Chou, S.M., 226, 227, 232Chowdhury, D., 170Chrisey, D.B., 236, 247, 248Christensen, B.E., 197, 202Christian, D., 15Christian, S.D., 60Christie, R.J., 5–7, 9

366 Author Index

Chu, B., 204, 208Chu, D.Y., 63Chu, K., 292Chu, Q., 9Chua, C.K., 226, 227, 230, 232Chuang, J.H., 256Chun, M.-K., 61Chung, H., 12Chung, J.E., 13Chytil, P., 11Cincu, C., 324Ciolina, C., 202Cipres-Palacin, G., 199Cirioni, O., 324Citro, G., 261Ciurana, J., 227, 230, 243Clair, P., 171Clamme, J.P., 9Clapell, J.M., 195Cleton, F.J., 256Cobanoglu, U., 259Coen, L., 208Coenen, H.H., 173, 176Coessens, V., 327, 328, 343Coffin, R.S., 189Cognolato, L., 245Cohen, A.J., 275, 280Cohen, D.L., 243, 246Cohen, J.I., 172Cohen, L., 170Cohen, M., 135Cohen, S., 323Cohen Stuart, M.A., 55Cohen, Y., 60, 68Coldrick, Z., 22Cole, M.L., 61Cole, S.W., 169Coleman, R.L., 169Cölfen, H., 103Collard, W.T., 192Collas, P., 202Colledge, W.H., 173, 174Collier, A., 188Collins, L., 204, 207Colton, C.K., 140Cometa, S., 226, 227, 232Concheiro, A., 59, 61Cone, R., 118Conover, C.D., 11Contado, C., 103Conti, E., 202Contreras, J.L., 143Cook, A., 202Cook, S.E., 200

Cooper, M.J., 10Cooper, R.G., 199Coote, M.L., 285Copetti, T., 259Corbel, S., 233Corot, C., 164Corr, D.T., 247Correa, R.G., 259Correia, I.J., 323, 324Corrie, P., 13Corrigan, O., 296, 306Corsi, K., 196Cortese, K., 318Corvalan, C., 282Cory-Slechta, D.A., 189Cosgrove, T., 55Costa, D., 68, 70Costa, P., 163, 164, 170Costa, T., 61Costello, L., 256Cotten, M., 13, 16, 17Cotton, M., 10Cotts, B., 95Coudane, J., 333Couraud, P.O., 203Coutelle, C., 199, 204, 208Couvreur, P., 117, 118, 204, 317–319, 321, 324Coviello, T., 323Coy, J.F., 256Craddock, B.L., 113Crane, A.M., 200Crane, L., 296, 306Crane, M., 296, 306Creely, K.S., 90Crétin, N., 131Creusat, G., 195Cristiano, R.J., 199Cristofaro, P., 170Croce, C.M., 256Crommelin, D.J.A., 7, 8, 18, 19, 202Crooke, S.T., 187Crooks, G., 172Crownover, E.F., 21Cruz, L.J., 321Cruz, R.P., 187Cruz-Chu, E., 281, 282Cryer, P.E., 130Csetneki, I., 338Cuenat, A., 94Cuendet, M.A., 283Cuezva, J.M., 256Cuhaci, B., 261Cui, D., 339Cui, H., 58

Author Index 367

Cui, W., 144–146Cui, X., 245, 246Cui, Z.Y., 18Cullis, P.R., 15, 16Culmsee, C., 163, 164, 170, 204Cundari, T.R., 273, 291Cupp, M.J., 262Curiel, D.T., 16Currie, J.C., 204, 205Cuthbert, A.W., 173, 174Cuvelier, D., 15Czarnecka, A.M., 256Czarnecki, J.S., 256Czernuszka, J.T., 243Czibere, A., 259

Dda Cruz, M.T., 163, 164da Silva, B.P., 232DaCosta, H., 273Daddario-DiCaprio, K., 169Dadhich, R.K., 257, 259Daft, E.L., 188Dahneke, B.E., 95Dai, H., 196, 197, 343Dai, J., 284Dai, Y., 264Dai, Z., 75Daldrup-Link, H.E., 164Dalhaimer, P., 15, 320Dalkara, T., 204Dalmoro, A., 324Damgé, C., 114, 116, 117, 135Damm, E.M., 8Damon, B.J., 243d’Amore, M., 324Dang, C.V., 259Dang, J.M., 51Danielsen, M., 14, 158, 190Danielsen, S., 197, 202Danjou, S., 230Dankert, J., 322Danne, R., 293Danson, S., 4, 13Darby, M.K., 202Darling, D., 16Darton, N.J., 22Das, S.R., 346DasGupta, B.R., 207Dash, M., 322, 324Dash, P.R., 193, 198Dass, C.R., 192, 323Dassie, J.P., 208

Daura, X., 283Dauty, E., 201Dauvarte, A.K., 263Davidson, B.L., 189, 204, 205Davidson, H., 173Davidson, J.M., 131, 132Davidson-Smith, H., 173Davies, E.G., 172Davies, J.C., 173, 174Davies, L.A., 174Davies, M.C., 5Davies, M.G., 173, 174Dávila-Pérez, R., 140, 141Davis, F.F., 4, 11, 12Davis, F.J., 227Davis, K.A., 327Davis, M.E., 195Davis, R.J., 61, 189Davis, S.S., 120Davis, T.P., 328Dawson, K.A., 72, 74, 75, 77, 78Dawson, M., 118Dawson, R.M.C., 259, 260de Almeida, L.P., 163, 164, 170, 204de Barsy, T., 200De Beer, T., 302de Boer, A.G., 120de Boer, J., 226De Campos, A.M., 75De Clercq, B., 332de Duve, C., 3, 200de Fougerolles, A., 169de Frutos, M., 70de Groot, M., 140, 142, 143de Haan, A., 140, 143de Haan, B.J., 140, 141, 143De Jager, R.L., 173, 175de Jong, W.A., 274, 307de Jonge, J., 16de Keizer, A., 55de la Fuente, M., 323de Leeuw, B.J., 120De, M., 197De Maria, C., 245De Palma, M., 189de Ruiter, G.C., 189de Saint Basile, G., 172de Saint, B.G., 172De Smedt, S.C., 192de Sousa, H.C., 324De Villartay, J.P., 172De Vos, F., 228de Vos, P., 140, 141, 143, 245de Vries, A.H., 284

368 Author Index

De Yao, K., 196Dean, D., 245, 246Debarsy, T., 3Debasitis, J.C., 246Debs, R.J., 199Debska, G., 71Decuzzi, P., 319, 320Deen, W.M., 5Déglon, N., 189Degols, G., 10Dehpour, A.R., 120Deierhoi, M.H., 130Deist, F.L., 172Deiwick, A., 236Del Carro, U., 189del Guerra, S., 134, 138Del Sole, R., 274Delabesse, E., 172Delacher, M., 77Deleers, M., 274Delie, F., 115, 120Deligkaris, K., 227D’Emanuele, A., 119Demeester, J., 192Demeneix, B.A., 14, 18, 194, 195Demeule, M., 204, 205Demir, A.S., 204Demir, H., 259Demirci, U., 246Demolombe, S., 201Deng, B., 204, 208Deng, J., 21Derby, B., 243, 245, 246Derksen, T.A., 189des Rieux, A., 118, 119, 144Desai, M.P., 10, 118, 200Desai, T.A., 324Desbat, B., 248Descoeudres, C., 262Deshpande, D., 2Deshpande, M., 245Deshpande, M.C., 5DeSimone, J.M., 316–321Desmangles, A.I., 134, 138Desmond, P., 11Dettmer, C.M., 345Devarajan, P.V., 281Deverre, J.R., 191Devissaguet, J.P., 117Devon, M.J., 103Dhert, W.J.A., 227, 233, 244–247Dheur, S., 194Dhumeaux, D., 11Dhup, S., 257, 259

di Girolamo, I., 189di Lena, F., 326di Luca, A., 322Diamond, D., 58Diamond, S.L., 10, 166, 202Dias, R.S., 65, 68, 70Diaspro, A., 134, 138, 322Díaz, V.M., 322Dice, J.A., 189Dickinson, B., 169Dietz, G.P., 190Digicaylioglu, M., 203Dinçer, S., 18Dinescu, M., 302Ding, D., 322Ding, H.M., 200, 204, 208Ding, J., 69, 328Ding, Z., 197Dinh, T.D., 171, 172Discher, B.M., 15Discher, D.E., 14, 15, 55, 294, 320, 342Dittmar, C., 173, 176Divita, G., 158Diwan, P.V., 119Dixon, D.E., 147Djupesland, P., 306Dobbelstein, M., 188Doble, M., 281Doherty, G.J., 76Dohner, K., 201d’Oliveira, C., 202Dollé, F., 191Domingos, M.A.N., 226, 227, 232, 239Dominowski, P.J., 22Dominski, Z., 188Domschke, W., 196Dong, A., 21Dong, H., 336Dong, L., 197, 200Dong, M., 171, 197Doody, A.M., 195Doraiswamy, A., 236Dorantes, L.M., 140, 141Dorin, J.R., 173Dorkin, R., 169Dorkoosh, F.A., 120, 285, 286dos Santos, S., 61, 68, 70dos Santos, T., 75, 78Dosescu, J., 261, 263Doshi, N., 316, 319, 320Dou, S., 324Dougan, G., 208Dow, S.W., 168Dowdy, S.F., 157

Author Index 369

Doyle, P.S., 320Doyle, R., 119Dräger, G., 236Drake, C., 244Drake, E.N. II., 259Drewes, G., 256Driot, J.Y., 323Driver, S.E., 168, 188Dropulic, B., 189Drummond, C.J., 49Drummond, D.C., 4Drumright, R., 334, 343Du, J., 15, 339, 342, 344Du, J.Z., 324, 344Du Prez, F.E., 61Du, Q., 21du Sart, G.G., 333Du, Y., 226, 241, 242Dualeh, A.J., 60, 68Duarte, S., 161, 162, 164, 166Dubernet, C., 324Dubin, P., 61Dubovi, E.J., 190Dubruel, P., 227, 228, 236Ducker, R.E., 55Dudukovic, M., 303Dufes, C., 193Dufour, J.M., 147Dufrane, D., 141, 143Dufresne, M.H., 13Duhem, N., 119Duncan, R., 3–6, 8, 9, 11, 21, 193Dunlap, D.D., 194Dunlap, J.R., 342Dunn, D.L., 130Dünnhaupt, S., 118Dunstan, D.E., 323Duocastella, M., 247, 248Dupuis-Girod, S., 172Duran, M., 259Duran, R.V., 259, 263Durham, S.R., 173, 174Duvall, C.L., 21Duzgoren-Aydin, N.S., 262Düzgünes, N., 5, 157–162, 165, 168, 191Dvir, T., 339

EEastman, P., 308Eastman, S.J., 160, 173, 174Eberli, F.R., 2Eccleston, M.E., 18, 19, 21, 22Echlin, P., 93

Eckhard, M., 140Eckhoff, D.E., 143Eckstein, C., 143Edelstein, M.L., 172Edminster, K., 246Edwards, K., 196Ee, P.L., 321Egan, J.J., 173, 174Ege, D.S., 15Egermayer, M., 60, 68Eggers, R., 189Ehlert, E.M., 189Ehrhardt, A., 2, 16Ehrlich, P., 3EI-Sayed, M.E.H., 20Eisele, K., 322Eisenbarth, G., 129Eisenberg, A., 12, 55, 330, 332–334, 340, 341Ejima, D., 104Ekdahl, K.N., 143El-Andaloussi, S., 165El-Aneed, A., 158, 192Elbashir, S.M., 168Eldar-Boock, A., 21Elder, M., 172Eldridge, J.H., 117Elgue, G., 143Elia, G., 74Elkadi, A., 264Elliot, D.C., 259, 260Elliot, W.H., 259, 260Elliott, J.R., 307Elliott, R.B., 140, 141Elsasser, H.P., 202El-Sayed, M.E., 194Elsner, C., 343Emerson, P.M., 264Encalada, R., 259, 261Endo, T., 69Endo, Y., 261, 263Enea, R., 340, 343Engbers, G.H., 322Engbers, G.H.M., 15Engler, A., 15Engler, H., 195Engquist, B., 273Enomoto, M., 189Ensign, D.L., 308Entezami, A.A., 325Epand, R.M., 18Erbacher, P., 196Erickson, D., 189Ernst, E., 264Erokhin, V., 322

370 Author Index

Erokhina, S., 322Esaki, T., 13Escande, D., 201Escriou, V., 170Etrych, T., 11Evagorou, E.G., 6Evans, D.F., 42Evans, M.J., 173, 174

FFaas, M.M., 140, 143Fabre, J.W., 204, 207Fahmi, A., 333Fahrmeir, J., 195Fairchild, T., 119Fairhurst, D., 103Fairman, J., 168Fairweather, N.F., 204, 208Fais, S., 261Falcao, C., 171Falkow, S., 200Fan, A., 187Fan, L., 204, 205Fan, M.H., 194Fan, Y., 169Faneca, H., 157, 158, 160–162, 164–166,

168, 191Fanelli, C.G., 112Fang, F., 262Fanun, M., 68Farhadi, A., 282Farley, R., 173, 174Farn, R.J., 38, 43Farokhzad, O.C., 2–4, 14, 15, 274Farrand, D.A., 208Farzaneh, F., 16, 22Fasano, S., 189Fasbender, A.J., 201Fatehi, D., 205Fattal, E., 118Faucon, M., 248Faure, C., 49Faustino, A., 161, 165, 168Fausto, N., 9, 20Fausto, R., 286, 290, 291Featherstone, C., 202Federici, T., 189, 208Federlin, K., 138Federoff, H.J., 189Fedorov, D.G., 276Fedorovich, N.E., 227, 233, 244, 245Fedoruk, M.N., 169Fehér, J., 338

Feijen, J., 15, 233, 234, 236, 322Feinstein, E., 186Feldman, E.L., 186, 189Felgner, J.H., 160, 161, 190Felgner, P.L., 5, 14, 158, 160, 161, 190, 191Fella, C., 195Felldin, M., 141Fenaroli, F., 77Feng, C., 164Feng, J., 60Feng, L., 204, 205Fenoglio, I., 77Ferguson, I.A., 204, 207Fernandes, J.C., 196Fernández, J.A., 143Fernandez, R., 204, 208Fernandez-Megia, E., 204Fernandezmejia, C., 11Fernyhough, P., 186Ferrari, M., 2, 71, 161, 319, 320Ferrari, S., 173Ferreira, P.J., 88Ferry, D., 4, 13Ferry, J.D., 56Feugeas, O., 199Field, C.J., 262Fields, A.L.A., 261Fievez, V., 118Figdor, C.G., 321Figueiredo, D.M., 208Figueiredo, I.V., 112Figueiredo, M.M., 88Filho, R.M., 243Filipcsei, G., 338Filipe, A., 158–162, 200Filipe, V., 100Filmon, R., 324Filo, R.S., 130Fink, D.J., 189Fink, T.L., 10Finsy, R., 98Fiori, C., 93Fire, A., 168, 188Firmino, F., 169, 171, 190Fischer, A., 172Fischer, D., 19, 194, 322, 324Fischer, K., 246Fisher, P.B., 259Fishman, P.S., 208Fissan, H., 90Fitzgerald, K., 169Fitzjohn, E.M., 173, 174Flegler, S.L., 91Florack, V., 2

Author Index 371

Florea, B.I., 196Florence, A.T., 114, 118, 119, 193Flores, G., 206Flory, P.J., 55Flynn, M.A., 170Flyvbjerg, A., 128Fokin, V.V., 328Fokkink, R., 321Folarin, N., 16Follenzi, A., 189Fong, C., 49Fonseca, A.C., 286, 290Fontana, J., 16Forgacs, G., 226, 244Forster, A., 172Forster, S., 330, 332, 333Forsythe, S.M., 261Fortunati, E., 202Foss, A., 141Foster, S., 21Foulkes, W.D., 164Fournier, B., 131Fournier, D., 328Fox, B.C., 233Fraier, D., 3Francis, C.L., 200Frank, D.B., 55Franke, T.F., 16Frank-Kamenetsky, M., 169Fraser, P., 172Frebourg, T., 172Frechet, J.M., 69Freddolino, P.L., 281, 282Fredenberg, S., 301Fredrickson, G.H., 60Freedman, N., 201Freeman, I., 323Freeman, J.S., 111Freese, A., 189Freichels, H., 316Freimark, B., 2Frenkel, D., 78Freudenberg, J., 15Frey, H., 193Freychet, P., 206Fricain, J.-C., 247, 248Fried, M.W., 11Friedel, G., 171Friedrich, T., 59Friedrichs, M.S., 308Friend, D.S., 15, 199Friesner, R.A., 275Frigerio, E., 3Fritz, E.A., 169

Frojmovic, M.M., 320Fu, G.D., 340Fu, J., 118Fu, R., 340Fu, S., 324Fu, X.B., 322Fubini, B., 77Fujii, M., 173, 174Fujimoto, K., 189Fujio, Y., 16Fujita, M., 204Fulton, D., 16Fumoto, S., 21Funhoff, A.M., 7, 8Furstenberger, P., 199Furth, E.E., 172Fuse, Y., 262Futaki, S., 165Futera, Z., 292Futran, N., 175

GGabathuler, R., 204, 205Gaber, A.O., 195Gabor, F., 119Gac-Breton, S., 3, 11Gadad, P., 120Gadek, T.R., 14, 158, 190Gaensler, K.M., 16Gage, F.H., 189Gagnor, C., 10Gait, M.J., 171, 187Galaev, I.Y., 70Gallagher, K., 296, 306Gallardo-Pérez, J.C., 259, 261Gallo, R.C., 191Galloway, J.A., 118Gamba-Vitalo, C., 169Ganesh, S., 200Gao, C., 339Gao, G.P., 172Gao, H., 327Gao, J., 166Gao, S., 197Gao, W., 274Gao, X., 164, 190, 208Gao, Y.X., 75Gar, T.K., 262, 263Garbarino, J.R., 104Garber, K., 256Garcia, A., 165Garcia-Villegas, R., 206Garcion, E., 118, 119

372 Author Index

Garfinkel, M., 141Garg, S., 58Garibay, G.N., 140, 141Garinot, M., 118Garland, M., 308Garlip, G., 173, 176Garnett, M.C., 5, 192, 194Garrec, D.L., 12Garred, O., 8Garrity-Moses, M., 208Garty, S., 324Gary, D.J., 18Gaspar, J., 232Gaspar, M.N., 324Gaspar, R., 158, 161, 162, 165Gaspar, V.M., 323Gatenby, R.A., 261, 263Gauss, J., 276Gauthier, M.A., 328Gaynor, S., 326Ge, Q., 194Geddes, D.M., 173, 174Gedeon, C.R., 10Geisbert, J.B., 169Geisbert, T.W., 169Geldenhuys, W., 204, 206Geldof, M., 196Gélinas, V., 94Geller, A.I., 189Gellert, P.R., 245Gelperina, S., 203Geng, Y., 320, 342Gennaro, A., 285Gentile, L., 56Gentry, C.A., 71George, P.M., 338Georgieva, M.P., 11Georgikopoulou, K., 342Gerace, L., 202Gerber, C., 93Gerber, G.B., 262Gerich, J.E., 112, 113, 128Germane, S.K., 263Germershaus, O., 227Gernaey, K.V., 302Gershenson, D.M., 169, 173, 175Gewirtz, A.M., 157Ghazani, A.A., 78Gherardini, L., 197Ghiazza, M., 77Ghinea, N., 199Ghiselli, R., 324Ghivizzani, S.C., 158Ghodsi, A., 189

Gholamipour-Shirazi, A., 116Ghoroghchian, P.P., 15Ghosh, P., 197Ghosh, R.N., 9, 15, 16Giacco, F., 128Giacometti, A., 324Giambanco, I., 207Giammona, G., 344Gianasi, E., 6Gianello, P., 141, 143Giangrande, P.H., 208Giani, G., 128Giardina, B., 256, 259Gibbs, K.M., 186Gibly, R.F., 141, 143, 144Gibson, M.I., 328Giddings, J.C., 103, 104Gil, M.H., 286, 290, 291, 324Gilboa, E., 16Gilchrist, F.M., 18, 21Gileadi, U., 173, 174Gill, D.M., 207Gill, D.R., 173, 174Gilley, R.M., 117Gillies, R.J., 261, 263Gingras, M., 194Glass, G., 2Glatter, O., 70Gleave, M.E., 170, 197Gleich, L., 175Glinka, C.J., 60Gliozzi, A., 134, 138Glisson, B., 175Glorioso, J.C., 189Gnanou, Y., 329–331, 334, 343Godbey, W.T., 10, 18, 194Goddard, C.A., 173, 174Goddard, E.D., 60, 64, 68Goebbels, R.M., 141Goethals, E.J., 61Goettmann, F., 60Goetz, F.C., 130Göhler, D., 90Goins, W.F., 189Gokhale, P.C., 171Golas, P.L., 328Goldblatt, H., 257Goldsmith, C.M., 172Goldstein, J., 93Golubovic, L., 47Gomes, P., 166Gomez-Orellana, I., 115Goncalves, A.R., 112Goncalves, C., 192

Author Index 373

Gong, C., 324Gong, P.J., 200Gonik, A.M., 321Gonzalez, A.M., 204, 207Gonzalez, R., 173, 175Gonzalez-Barrios, J.A., 204, 206Gonzalez-Bernal, V., 204, 206Gonzalez-Perez, A., 70Goodhead, L., 16Goodhew, P.J., 91Goodman, S., 262, 263Goodwin, A.P., 343Goodwin, J., 38, 43Gooi, H.C., 173, 174Goppert, T.M., 75Gordon, D., 190Gordon, M.S., 276Gori, S., 12Goss, J., 189Goss, J.A., 141, 143Gosselin, M.A., 195Gossmann, A., 173, 176Goto, M., 143Gottlieb, E., 259, 263Gottschalk, S., 199Gou, M., 324Gough, J.E., 246Gough, S., 129Goula, D., 195Goumaz, C., 131Gour, N., 200Gousset, K., 318Govender, T., 21Govind, N., 274, 307Graça Miguel, M., 68, 70Grace, M., 11Graham, J.G., 141, 143, 144Graham, M.L., 4, 11Graham, R.W., 10Grainger, D.W., 5–7, 9Grandér, D., 256Granier, C., 206Granja, P.L., 193Granqvist, C.G., 94Gratton, J.P., 16Gray, A.I., 119, 192, 193Gray, S.J., 189Grayson, A.C., 195Greber, U.F., 201Green, A.M., 174Green, J.J., 197Green, L.G., 328Green, M.S., 56Green, S., 308

Greene, M.I., 15Greening, A.P., 173Greenwald, R.B., 11Greenwood, J., 203Gref, R., 5, 75Grefhorst, A., 169Gregoriadis, G., 6Gregoriadis, G.C., 259Greiser, U., 322Greszta, D., 326, 327Griebel, M., 282Griesenbach, U., 173, 174Griffin, J., 207Griffin, J.H., 143Griffith, L.G., 6, 243Griffiths, G.L., 22Grijpma, D.W., 233, 234, 236, 249Gritti, A., 189Grobholz, R., 256Gropeanu, R., 322Grosdidier, A., 283Gross, F., 172Groutsi, F., 189Gruessner, A.C., 130Gruessner, R.W., 130Grumet, M., 186Grund, S., 322, 324Grupillo, M., 134, 138Gu, F.X., 2Gu, G., 208Gu, X., 259, 262Gu, Y., 141, 146Gu, Z., 200Guan, H., 21, 196Guerrero-Cazares, H., 197GuhaSarkar, S., 322Guillemet, F., 60, 62, 63, 68Guillemot, F., 247, 248Guillotin, B., 247, 248Guiot, Y., 141Guliashvili, T., 285Gumbleton, M., 6Gunn, J., 323Guo, C., 197Guo, G., 324Guo, J., 208Guo, L., 204, 205Guo, Q., 324Guo, R., 322Guo, S., 21Gupta, A.K., 75Gupta, M., 75Gupta, R., 335–337Gupta, S., 95

374 Author Index

Gurevich, V., 190Gurny, R., 115, 120, 324Gursoy, R.N., 204Gurtovenko, A.a., 284Gustafsson, K., 207Gustavsson, B., 70Gustavsson, P.E., 70Gutowska, A., 58Guvendiren, M., 228

HHaag, R., 340, 343, 345, 346Haardt, M., 10Hacein-Bey, S., 172Hacein-Bey-Abina, S., 172Haddish-Berhane, N., 282Haddleton, D.M., 346Hadgraft, J., 58Hadjichristidis, N., 327, 342Hadwiger, P., 169Hadzic, G., 318Haeggstrom, E., 246Haensler, J., 14, 18, 193Hafez, I.M., 15Haggie, P., 201Haghgooie, R., 320Haghighi, K., 282Hagstrom, J.E., 9, 190Halbert, G., 4, 13Halbert, G.W., 118Halder, J., 169Haller, C.A., 144, 145Hallewell, R.A., 208Halperin, M.L., 261Halpern, J.L., 207Hamaguchi, T., 13Hamidi, M., 196, 228Hamm-Alvarez, S., 165Hammer, D.A., 15Hammond, C.J., 117Hammond, P.T., 342, 343Han, C., 60, 273Han, D., 75Han, G., 197Han, L., 204, 205Han, L.Y., 169Han, S., 21, 194Han, S.O., 197Han, X., 256Han, Y.F., 323Han, Y.Q., 323Han, Z., 189Hanasawa, K., 261, 263

Hanazono, Y., 189Hancock, J.F., 318Hanes, J., 116, 118Hang Tle, B., 119Hanna, E., 175Hannan, R.B., 60Hannavy, K., 173, 174Hansen, O.C., 197Hanson, R.W., 10Hansson, P., 68, 69Hantraye, P., 189Harada, A., 12, 340Harashima, H., 165, 191Harborth, J., 168, 169Harbottle, R.P., 199Hardwick, J., 308Hardy, D.J., 307, 308Harman, E., 262, 263Harris, I.S., 259Harris, J.M., 4, 5, 12Harris, M., 136, 140, 141Harris, T.J., 306Harrison, K., 204, 206Hart, B.T., 104Hart, S.L., 199Hartley, G., 40Hartmann, H., 197Harvie, P., 161Hasan, S.K., 246Hasenkamp, W.M., 140Hashida, M., 171, 172, 188Hashim, A.I., 261, 263Hashimoto, M., 200Hashizume, Y., 174Haskal, Z.J., 172Haskins, K., 136, 143Hasnain, S.E., 16Hassan, A., 195Hassan, M.A., 323Hassan, Q., 16Hassanzadeh, D., 325Hasu, M., 199Hatakeyama, H., 165Hatano, M., 173, 174Hauck-Schmalenberger, I., 146Hawe, A., 100Hayashi, Y., 165He, C., 196, 321He, J., 136, 143He, M.L., 200He, S., 262He, Z., 332Heald, A.E., 175Healy, A., 296, 306

Author Index 375

Heath, J.P., 93Heath, T.D., 199Heckman, J.W., 91Hedrick, J.L., 339Hefford, R.J., 61Hefter, H., 186Heidel, J., 195Heider, H., 15Heider, K.H., 194Hein, S., 197Heinemann, L., 113Heiney, P.A., 228Heintz, R.E., 136, 140, 141Heinze, T., 323Heise, T., 113Heiss, W.D., 173, 176Heitz, F., 158Helenius, A., 8, 202Helfrich, W., 47Heller, G., 16Heller, J., 324Hellweg, R., 186Hendriks, W.T., 189Henkel, T., 40Henning, T.D., 164Hennink, W.E., 7, 8, 14, 18, 19, 135, 192, 202,

227, 233, 244, 245, 343Henriques, A., 166Henry, J., 343Henry, S.M., 20Hensley, L.E., 169Herbert, B.S., 18Hering, B.J., 141, 143, 144Herlihy, K.P., 316, 319–321Hernandez-Deviez, D.J., 318Herold, K., 129Herrero, M.A., 197Hershfield, M.S., 11, 172Herzog, R.W., 188Hess, B., 262Hess, K.R., 346Heszler, P., 94Heth, J., 189Heth, J.A., 189Hettiarachchi, H., 306Hewett, P.W., 188Heyes, J.A., 169Higgins, C.F., 173, 174Higuchi, M., 292Higuchi, N., 21Higuchi, Y., 171, 172Hilditch, T.E., 3Hill, M.M., 318Hillaireau, H., 117, 317–319, 321

Hillebrands, J.L., 141Hillmyer, M.A., 330–332Hincal, A.A., 204Hindle, M., 301Hinh, L., 189Hirai, H., 167Hirai, T., 189Hirano, S., 189Hirschhaeuser, F., 259Hiruma, Y., 246Ho Kang, S., 195Ho, L.P., 173Ho, V.H.B., 16, 22Ho, Y.C., 119Hoare, T.R., 227Hobbs, S.K., 6Hodgkin, M.N., 204, 207Hodgson, J.L., 285Hodson, M.E., 173, 174Hoek, E.M.V., 77Hoekstra, D., 199Hoel, A., 94Hoffman, A.S., 2–5, 7–14, 18–21, 321Hofland, H.E., 164, 199Holbrook, L.T., 296, 305, 306Holladay, C., 322Holler, E., 204Hollinger, J.O., 334, 343Hollister-Lock, J., 140Holloway, K., 203Holm, M., 14, 158, 190Holmberg, H., 38, 41, 43, 46, 50, 55, 57, 58,

60, 61, 63, 64, 69Holthausen, M.C., 275Holtrop, M., 16Hombach, J., 118Hong, C., 333Hong, J.W., 200, 246Hong, K.L., 4, 15, 162Hong, S., 2, 4, 14, 15Hong, X., 342Honkakoski, P., 199Hoo, C.M., 94Hoogenboom, R., 328Hoogendam, C.W., 55Hoogeveen, A.T., 202Hor Keong Tan, W., 299, 305Horber, F.F., 262Horcher, A., 138Hori, H., 141, 146Hori, K., 13Hori, Y., 323Horie, M., 246Horner, P.J., 9, 204, 208

376 Author Index

Hornig, S., 323Horrigan, E.M., 323Hortobagyi, G.N., 173, 175Horton, H.R., 21Horton, J.D., 169Horwitz, B.A., 15Hour, A.L., 77Houston, M., 308Hovanesian, V., 170Howard, K.A., 197Howes, M.T., 318Howse, J.R., 55Hrubý, M., 4Hsiue, G.H., 4Hsu, C.W., 189Hsu, Y., 306Hu, B.H., 142, 145Hu, H.Z., 168Hu, J., 204, 285Hu, K.Y., 77Hu, X., 189, 328Hu, Y.Q., 321, 344Huang, C., 262Huang, C.C., 321, 323Huang, C.-I., 70Huang, C.T., 4Huang, G., 248Huang, J., 284Huang, J.W., 189Huang, L., 5, 158, 162, 166, 169, 173–175,

188, 190, 191, 193, 198, 245Huang, P., 259, 261Huang, R.Q., 200, 204–206Huang, S., 204, 205Huang, S.Y., 322, 324Huang, Y., 21, 207, 248, 328Huang, Y.H., 77Huang, Z., 197Hubbard, A., 58, 59Hubbell, J.A., 15, 18, 20Huchriede, A., 16Hue, C., 172Huggins, M.L., 55Hughes, D.W., 340, 343Hughes, H., 262Hughes, J.A., 166, 172Hughes, R.A., 186Hughes, S.M., 189Hui, S.W., 191Huisgen, R., 328Humar, A., 130Humbert, W., 117Humphreys, F.J., 91Hundt, E., 118

Hünenberger, P.H., 283Hung, M.C., 173, 175Hung, Y., 76Hungerer, K.-D., 118Hunkeler, D., 141Hunt, S.P., 189Hunter, A.C., 23, 71Hunziker, P., 15Huo, Q., 60Hur, J., 186Hurley, N., 296, 306Hurtado, P.R., 204, 207Husebye, H., 202Hussain, N., 119Hutmacher, D.W., 227, 243Hutter, D., 2Hwang Do, W., 204, 205Hwu, W.-M.W., 308Hyatt, S.L., 10Hyde, S.C., 173, 174Hyndman, L., 166Hynes, R.O., 323

IIatrou, H., 327Ibarboure, E., 338Ibrahim, N.K., 173, 175Ichinose, S., 189Iemma, F., 274Iginla, S., 164, 199Ignatenko, M.A., 263Ignatovich, L.M., 263Iijima, S., 169Ikeda, M., 13Ikeda, R., 13Ikeguchi, K., 189Iken, M., 146Ilekti, P., 67Ilias, I., 60Iliopoulos, I., 60Illum, L., 120Imamoto, N., 202Imanishi, J., 167Imanishi, Y., 21Imazeki, N., 262Imperiale, M.J., 189, 208Innerlohinger, J., 70Innes, J.A., 173Inoue, K., 141, 146Inoue, S., 204Inoue, T., 12Irvine, D.J., 323Isenberg, J., 259

Author Index 377

Ishibe, A., 12Ishii, K., 169Ishii, T., 196Ishikawa, M., 262Ishiwara, F., 262Israel, M., 259Israelachvili, J.N., 42, 331Issa, M., 197, 202Isse, A.A., 285Itai, S., 12Iten, P.X., 262Ito, E., 165Ito, K., 261Ito, Y., 21Itoh, S., 189Iwakura, Y., 167Iwasaki, Y., 69, 169, 246Iwata, H., 131, 134–136, 138–141, 143–146Izaurralde, E., 202Izumrudov, V.A., 70Izvekov, S., 284

JJack, V., 192, 193Jackson, J.K., 197Jacobs, A.H., 173, 176Jacobson, B.E., 204, 208Jaeger, P., 262Jaffe, A., 173, 174Jaffres, P.A., 158–160Jahr, H., 140Jahrling, P.B., 169Jaillard, D., 118Jain, A., 119Jain, J., 95Jain, R.K., 6Jain, S.K., 119Jakab, K., 226Jakobsson, J., 189Jakubowski, W., 330Jalota, S., 243Jamison, J.R., 262Jan, M.D., 343Janardhanan, K.K., 264Janes, K.A., 196Jang, H.S., 194Jani, P.U., 118, 119Jans, D.A., 166, 202Janssen, C.L., 274, 307Jardini, A., 243Jarmelo, S., 286, 290, 291Jarver, P., 170Jayakumar, R., 228Jayaprakash, K.N., 169

Jayaram, B., 283Jayaraman, M., 169Jayasinghe, S.N., 245Jearawiriyapaisarn, N., 188Jeffery, P.K., 173, 174Jeffs, L.B., 169Jelinek, M., 236Jennings, N.B., 169Jensen, G., 195Jensen, K., 169Jeon, G., 338Jeon, O., 322Jeong, B., 58, 197Jeong, H.J., 200Jeong, J.H., 12, 13, 204, 205, 234, 235,

237, 238Jeong Lee, H., 203, 204Jeong, S.Y., 12Jeong, Y.I., 12Jerome, C., 316Jerome, R., 316Jesser, C., 135Jevprasesphant, R., 119Jézéquel, J.Y., 233Jezova, D., 203Jhon, M.S., 336Jia, D., 18Jian, C., 160Jiang, C., 200, 204–206Jiang, D.L., 12Jiang, H.L., 200Jiang, R., 322Jiang, X., 204, 205, 208, 322, 339, 343Jiang, Y., 226, 227Jiao, F., 21Jiménez, I., 206Jin, C., 236Jin, G.W., 195Jin, H.C., 256Jin, S.E., 171Jinek, M., 202Jing, X., 328Jing, Y., 200Jinno, S., 12Jirik, F.R., 257Jiskoot, W., 100Joachim Loo, S.C., 321Joanny, J.F., 58Jockers-Scherubl, M.C., 186Johansson, H., 143, 165John, M., 169Johnsen, M.G., 197Johnson, J., 193Johnson, L.G., 199

378 Author Index

Johnson, M., 262Johnston, J.C., 189Johnston, T.P., 119Jolivalt, C.G., 186Jones, A., 318Jones, A.T., 6Jones, B.D., 200Jones, K.M., 259, 260Jones, M.C., 12Jones, R.A., 20, 55Jones, T.A., 164Jonsson, B., 38, 41, 43, 46, 50, 55, 57, 58, 60,

61, 63, 64, 67, 69Jordan, O., 134, 138Jorgensen, C., 170Jorgensen, W.L., 276, 283Joseph, M., 259Joshi, P.B., 10Jowle, D., 4, 13Joy, D.C., 93Joy, P.A., 338Juang, J.H., 119Judge, A.D., 169Jung, K.E., 204, 205Jung, S., 4, 6, 7Jung, T., 118Junginger, H.E., 120, 196, 285, 286

KKabanov, A.V., 12, 13, 63, 317, 318Kadam, S.S., 135Kafri, T., 189Kagan, E., 169Kagawa, Y., 326Kahn, A., 189Kaji, H., 322Kajimoto, K., 165Kajita, Y., 173, 174Kakimoto, N., 263Kakimoto, S., 200Kakizawa, Y., 12Kalia, M., 318Kalicharan, R., 199Kalinski, H., 186Källen, R., 141Kallmeyer, G., 173Kamat, A.A., 169Kamigaito, M., 326Kamm, W., 118Kanamori, T., 76Kanatani, I., 322Kandasamy, S.K., 284Kandaswamy, R., 130

Kandil, O., 264Kaneda, I., 59Kaneda, Y., 134, 138, 140, 143, 167Kane-Goldsmith, N., 186Kaneko, M., 261, 263Kanematsu, A., 322Kang, H., 338Kang, K.S., 234, 235Kanisawa, M., 262Kanjane, S., 316, 335–337Kano, A., 193Kano, H., 200Kaplan, B.J., 262Kapoor, N., 172Karabalin, N., 204Karanikolopoulos, N., 342Karlberg, M., 60, 68Karlsson, L., 67Karlström, G., 44, 56, 65Karp, J.M., 2, 4, 14, 15Karperien, M., 226Kartenbeck, J., 8Karttunen, M., 293Kasid, U.N., 171Kaspar, B.K., 189Kastenholz, M.a., 283Kasyanov, V., 244Katakai, Y., 169Kataoka, K., 12, 334, 340, 343Katas, H., 196, 197Kato, J., 169Kato, K., 13Katre, N.V., 5Katsampas, I., 332, 333, 338Katz, J.S., 338Katz, R.L., 173, 175Kaufman, D.B., 142, 145Kaul, G., 5Kaushal, A.M., 58Kaushik, R., 324Kawahara, H., 12Kawakami, S., 171, 172Kawakami, Y., 141, 146Kawamoto, T., 146Kawano, Y., 169Kawashima, T., 322Kay, M.A., 2, 16Kaye, S.B., 3Ke, W.L., 200, 204, 205Keane, R., 3, 11Keddle, A., 6Keegan, M., 140Keeney, M., 322Keerl, M., 59

Author Index 379

Keffer, D.J., 282Keles, H.O., 246Keller, G., 16, 131Kellomäki, M., 233, 249Kenady, D., 175Kennedy, W.R., 130Kenny, G.P., 129Kerr, D., 4, 13Kesari, P., 243, 245Keshavarzian, A., 282Kessler, L., 135Keyes, D.E., 282Khademhosseini, A., 226, 241, 242, 246Khalil, S., 246, 247Khan, A., 56Khan, I.A., 262Khandare, J., 334Kharkevitch, D., 173, 175Khokhlov, A.R., 58Khormaee, S., 21, 22Khoury, M., 170Khristov, V., 246, 247Khromanova, N.Y., 263Khuller, G.K., 75Khutoryanskiy, V.V., 118Khvorova, A., 188Kiang, T., 14, 19, 20, 195, 196Kiani, M.F., 300Kidszun, A., 146Kiebish, M.A., 256Kiick, K.L., 322, 323Kikuchi, H., 190Kilbourn, R.G., 173, 175Kim, B.S., 344Kim, C.K., 12, 171, 197Kim, E.E., 323Kim, E.M., 200Kim, H.J., 194Kim, H.-W., 243, 244Kim, H.Y., 4, 6, 7Kim, I.S., 12, 200Kim, I.Y., 200Kim, J.A., 194Kim, J.K., 330, 332, 333, 338Kim, J.M., 194Kim, J.S., 194Kim, J.W., 259Kim, J.Y., 264Kim, J.-Y., 234, 235Kim, K., 194Kim, M.H., 204, 205Kim, M.S., 322, 344Kim, S.H., 12, 13Kim, S.I., 322

Kim, S.T., 171, 197Kim, S.W., 12, 13, 193–195, 197Kim, T.H., 200Kim, T.I., 194Kim, W.J., 204, 205Kim, W.U., 4, 6, 7Kim, Y., 15, 18, 330, 332, 333, 338Kimura, M., 13Kin, T., 147King, C.A., 207King, D.J., 11Kingsman, S.M., 16Kircheis, R., 194Kirik, D., 189Kirk, R., 135Kirkham, M., 8, 318Kirkland, S.E., 340Kirkpatrick, N.D., 261, 263Kirlappos, H., 16Kishida, T., 167Kissel, T., 18, 19, 118, 194, 195, 321Kita, M., 167Kitabgi, P., 206Kitagawa, T., 190Kitahara, T., 21Kiwada, H., 191Kjems, J., 197Kjøniksen, A.L., 56Klaessig, F., 77Kleideiter, E., 171Klein, J.J., 9Klein, M.L., 15, 282, 284, 294Klein, T.J., 227Kleven, M., 306Klibanov, A.M., 194Klok, H.A., 328Klomparens, K.L., 91Klopsch, R., 193Klotz, U., 171Klumb, L.A., 20Kluska, M., 263Knapek, S., 282Kneteman, N.M., 130, 141Knight, A., 204, 208Knight, A.M., 199Knipe, D.M., 170Knoll, W., 40Knott, R., 120Ko, J.J., 194Ko, Y.T., 171Kobayashi, A., 246Kobayashi, S., 12Kobune, M., 169Koch, C., 13, 14, 16–18

380 Author Index

Koch, W., 275Kodama, M., 261, 263Kodama, Y., 21Koe, G.S., 198Kohane, D.S., 227, 274, 339Kohanim, S., 323Köhler, P., 230Kohn, D.B., 172Kok, M.R., 172Kokavecz, J., 94Kole, R., 170, 171, 188Kolesnikov, S.P., 262Koller, H., 186Kollman, P.a., 283Koltover, I., 14, 161Konak, C., 4, 194, 198Konda, B., 204Kong, H., 234, 235, 237, 238Kong, H.J., 323Kong, H.U., 197Konieczny, S.F., 18, 202Koning, G.A., 202Konkin, T., 170Konkolewicz, D., 346Konopka, K., 168Konovalov, O., 322Koo, H., 195Kooistra, T., 8Kopecek, J., 3, 5, 6, 9, 11, 18, 195, 321Kopeckova, P., 3, 6, 11Koping-Hoggard, M., 196, 197, 202Kopniczky, J., 94Korbutt, G.S., 130, 141, 147Korsgren, O., 141, 143Kostarelos, K., 197Kostas, S.A., 168, 188Kostin, S., 202Kostka, V., 9Kosztin, I., 244Kotb, M., 195Koteliansky, V., 169Kotin, R.M., 189Kotzé, A.F., 120Kowalczyk, T.H., 10Kowalewski, T., 332Kowalski, K., 274, 307Koynov, K., 322Koynova, R., 160Kozarsky, K.F., 189Kozlowski, A., 4, 12Kracht, L., 173, 176Krapf, R., 262Kratz, F., 322, 345, 346Krause, E., 346

Kräutler, V., 283Kravchenko, I.M., 263Krebs, H.A., 256Krebs, M.D., 322, 323Kremer, K., 275Krentz, A.J., 129Kreuter, J., 196, 203Kreutz, W., 15Krieglstein, J., 19Krijgsveld, J., 322Krishnamoorthy, G., 318Krisky, D., 189Kristen, J., 333Kritikou, E., 256Krizman, D.B., 248Kroemer, G., 259Krol, S., 134, 138Kronbreg, B., 38, 41, 43, 46, 50, 55, 57, 58, 60,

61, 63, 64, 69Kros, A., 227Kruijtzer, J.A.W., 7, 8Kruth, J.-P., 227, 230, 243Kryscio, D.R., 2, 3, 335Kubo, T., 167Kubodera, T., 169Kubota, T., 262Kuhlbusch, T.A.J., 90Kuhnast, B., 191Kuhry, J.G., 9Kuijpers, A.J., 322Kuiper, M., 18, 21Kuis, W., 172Kukol, A., 284Kukowska-Latallo, J.F., 193Kukwa, A., 256Kukwa, W., 256Kulamarva, A., 322Kulikov, G.A., 263Kumar, A., 346Kumar, P., 169, 170, 204, 205Kumar, R., 160, 161, 187, 190Kumar, V., 324Kumari, A., 322, 324Kumari, S., 318Kumar-Singh, R., 189Kumasaka, N., 322Kume, A., 189Kumria, R., 324Kunath, K., 194, 195Kung, H.F., 200Kurosaki, T., 21Kurzchalia, T., 8Kusano, K., 189Kusonwiriyawong, C., 20

Author Index 381

Kuwabara, M., 263Kwak, J.C.T., 60–63, 66, 69Kwan, Y.W., 264Kwon, E.J., 204, 208Kwon, G.S., 3, 5, 12, 13Kwon, H.Y., 12Kwon, I.C., 12Kwon, O., 264Kyriakides, T.R., 7, 21

LLabarre, D., 324Labat-Moleur, F., 199Labhasetwar, V., 10, 13, 118, 200Labrugère, C., 338Lackey, C.A., 20Lacy, P.E., 130Ladhoff, A., 199Ladmiral, V., 328Ladouceur, H.D., 247, 248Laduron, P.M., 206Lafleur, M., 5, 18Lagarce, F., 118, 119Lahann, J., 319–321Lahav, R., 186Lahiri, M.K., 160Lai, S.K., 116, 118Lai, Y., 146Laine, C., 164Lakey, J.R., 130, 141Lakshmi, B., 264Lam, C.X.F., 243Lam, E.K., 256Lam, J.K.M., 18Lam, K.S., 169, 321Lamberti, G., 324Lampela, P., 194Lan, P.X., 234Landau, D.P., 273Landen, C.N. Jr., 169Landfester, K., 77Langbein, S., 256Langel, U., 165, 170Langer, R.S., 2–5, 14, 15, 71, 111, 157, 169,

192, 197, 226, 274, 338Langridge, J., 118Lanni, F., 201Lao, F., 75Lao, L.L., 301Laperre, J., 332Largeau, C., 170Larijani, B., 120Larson, R.G., 284

Larsson, P.O., 70Larsson, R., 141, 143LaRue, I., 55Laschewsky, A., 333, 338, 339Lasic, D.D., 161Lasiene, J., 204, 208Latchman, D.S., 189Lattanzi, A., 189Laufer, S.D., 157, 170Laughton, C.A., 188Laurencin, C.T., 322–324Laurent, T.C., 60Lauris, V., 132Lausier, J., 166LaVan, D.A., 338Lavasanifar, A., 3, 5, 12, 13, 324Lavigne, P., 196Lawrence, M.J., 50Lawton, A.E., 174Lazzoi, M.R., 274Le Deist, F., 172Le Gal La Salle, G., 16Le Garrec, D., 4Le Grand, S., 308Leake, D., 188Leamon, C.P., 164, 199Lebleu, B., 10, 166, 171Leboulch, P., 172Lebraud, E., 248Lechardeur, D., 10, 158, 201Lecommandoux, S., 329–331, 334, 343Ledley, F.D., 187, 200Lee, A.C., 169Lee, B.H., 60Lee, B.-K., 234, 235Lee, C.K., 19, 21Lee, D.S., 200, 204, 205, 344Lee, G.-S., 243, 244Lee, H., 18Lee, H.B., 336Lee, H.I., 332, 334, 343Lee, H.K., 200Lee, J., 261Lee, J.C.M., 15Lee, J.H., 194, 322Lee, J.-H., 246Lee, J.L., 164Lee, J.S., 18, 321Lee, J.W., 234, 235Lee, K., 12Lee, K.C., 200Lee, K.M., 171, 200Lee, K.-W., 233Lee, K.Y., 227

382 Author Index

Lee, L.K., 195Lee, L.Y., 296, 299–301Lee, M., 195Lee, M.-Y., 226, 227Lee, P.W., 18Lee, R.J., 164, 190, 193, 195Lee, R.Y., 328Lee, S.C., 12Lee, S.H., 12, 13, 234, 235Lee, S.J., 170Lee, S.K., 170, 195, 204, 205Lee, S.M., 264, 345Lee, T., 299, 305Lee, V.K., 246Lee, W., 246Lee, W.K., 4, 6, 7Lee, Y., 330, 332, 333Lee, Y.B., 12, 194, 195, 197, 200Lee, Y.J., 169Leeman, S.E., 206Leenhouts, J.M., 16Legeay, G., 135Legendre, J.Y., 191Leggett, G.J., 55Legrand, S., 308Lehn, P., 158–160, 164Lehr, C.M., 171Lei, S., 169Leirdal, M., 170Leitner, A., 119Leiva, L.E., 172Lele, B.S., 346Lemiegre, L., 164Lemieux, P., 12Lemmi, A., 141Lemoine, J.L., 166Lendeckel, W., 168Lentz, T.B., 189Lenz, T., 283Leonard, A., 262Leonetti, J.P., 10Leong, K.W., 14, 19, 20, 51, 195, 196, 324Leroux, J., 115, 341, 342Leroux, J.C., 4, 5, 12, 13, 18–20Lesniak, A., 77Lessard, D.G., 12Leu, M., 227, 230, 243Leung, A., 136, 138, 139, 142, 143Leung, C.H., 189Leung, G.P., 264Leung, P.S., 60, 68Leveque, M., 203Levine, D.H., 15Levine, S.A., 262

Levy, G., 227, 230, 243Levy, R.J., 10, 118, 200Levy, Y., 11Lewis, A.L., 15, 18, 336, 342, 344Lewis, D.L., 9Lezoualc’h, F., 14, 18, 194Li, C., 21Li, D., 173, 174Li, D.S., 10Li, H., 164, 174, 292Li, J., 168, 292, 322Li, J.Y., 189, 203–206Li, L., 200, 259Li, L.Y., 75Li, M.H., 15Li, P., 164Li, R.H., 133–136Li, S., 12, 13, 21, 191, 198Li, S.D., 158, 162, 169Li, W., 75, 346Li, W.J., 16–18, 21Li, X., 168, 322Li, Y., 187, 200, 321, 343Li, Y.X., 19Li, Z., 190, 197, 332Liang, B., 200Liang, E., 338Liang, H.F., 4Liang, W., 166Liang, X.J., 21Liang, Y.J., 77Liang, Z., 21Liao, H.-T., 226, 227Liao, Z.X., 18Libermann, T.A., 259Licciardi, M., 342, 344Lieberman, J., 170Lieberwirth, I., 322Liechty, W.B., 2, 3, 22, 335Lifshin, E., 93Like, A.A., 132Lilley, C.E., 189Lim, A., 172Lim, A.S.C., 226, 227, 232Lim, F., 132, 140Lim, H.W., 195, 196Lim, I.S., 95Lim, Y.B., 194, 197Lima, W.F., 187Limpanuphap, S., 243Lin, A., 11Lin, C.C., 146, 343Lin, C.S., 189Lin, C.Y., 285

Author Index 383

Lin, D., 21Lin, F., 246Lin, F.H., 141Lin, H., 276Lin, J., 12, 13Lin, K.M., 119Lin, K.Y., 196Lin, L., 11, 19, 20Lin, P.C., 343Lin, S., 12, 13Lin, V.S., 197Lin, Y., 248, 322Lin, Y.G., 169Lin, Y.H., 119Lindahl, M., 206Lindh, R., 274, 307Lindman, B., 38, 41, 43, 44, 46, 50, 55–58,

60–65, 68–70, 162Lindman, S., 75Lindmark, T., 120Lindner, P., 59Lindsay, M.R., 318Linn, T., 146Linninger, A.A., 305, 306Lins, R.D., 283Linse, P., 61, 62Linse, S., 75Lipkowitz, K.B., 273, 291Lippoldt, A., 203Lipson, H., 243, 246Liska, R., 233Liskamp, R.M., 135Listak, J., 330Litzinger, D.C., 5Liu, A., 195Liu, B., 322Liu, C., 208Liu, C.Y., 164, 168Liu, D., 164, 190, 197Liu, F., 188, 190, 193Liu, G., 10Liu, G.Y., 75Liu, H., 246, 338Liu, J., 256, 328Liu, J.J., 204, 208Liu, J.K., 197, 208Liu, L., 318Liu, M., 339Liu, P.Y., 261Liu, Q., 227Liu, S., 204, 205, 285Liu, S.Y., 338, 339, 342Liu, V.A., 236, 240Liu, W.G., 196

Liu, X., 256Liu, X.Y., 141, 197, 208Liu, Y., 21, 164, 264Liu, Y.B., 196, 200, 204–206Liu, Z., 197, 343Livengood, M., 274, 275Livolant, F., 70Ljubimov, A.V., 204Ljubimova, J.Y., 204Lloyd, A.W., 344Lloyd, J.B., 8, 199Lo, E., 226, 241, 242Lo, E.H., 198Lobmaier, C., 119Lochner, N., 119Lockey, R., 200Lockridge, J.A., 169Lodde, B.M., 172Logan, A., 204, 207Lojkowski, W., 89Lok, M.C., 7, 8, 343Lomas, H., 15Lombardi, P., 281Long, H., 164Longest, P.W., 296, 301, 305, 306Loos, C., 77Loos, K., 333Lopez, J., 248Lopez, V.C., 58Lopez-Berestein, G., 169, 173, 175Lord, S.J., 147Lorenz, K., 193Lou, J., 131, 204–206Louche, G., 328Louis-Plence, P., 170Loussouarn, G., 201Loverde, S.M., 294Low, P.S., 164, 193, 199Low, R.B., 8Lowe, W.L. Jr., 141–145Lowenstein, P.R., 189Ltstedt, P., 273Lu, A.H., 343Lu, D., 281, 282Lu, D.W., 190Lu, F., 76Lu, J., 245Lü, J., 339Lu, J.J., 194Lu, L., 233Lu, Q., 246Lu, W., 259, 333Lu, Y., 164, 239, 242Lu, Y.Y., 189

384 Author Index

Lu, Z.R., 3, 6, 11Luan, N.M., 144, 145Lubeley, M.W., 324Luby-Phelps, K., 201Luca, G., 141Lucas, P., 192Luculescu, C.R., 302Ludtke, J.J., 202Luebke, D., 308Lueßen, H.L., 120Luessen, H.L., 120Luhmann, T., 227Luigjes, B., 61Lukacs, G.L., 10, 158, 201Lukan, N., 256Lukevics, E.A., 263Lukyanov, A.N., 4, 12Luna, J., 204, 206Lunardi-Iskandar, Y., 191Lundberg, C., 189Lundberg, D., 68, 162Lundberg, P., 165Lundgren, T., 141Lundin, K.E., 195Lundmark, R., 318Lundqvist, M., 74Lunn, J.S., 186Lunov, O., 77Luo, D., 7Luo, E.S., 204, 207Luo, F., 324Luo, J., 95, 321Luo, K., 200Luo, L., 12Luo, X., 141, 143, 144Lupold, S.E., 208Lupu, R., 21Lutgendorf, S.K., 169Lutz, J.F., 328, 346Luzio, J.P., 9Luzzatto, L., 16Lwata, H., 134, 138, 146Lyckholm, L.J., 261Lykissas, M.G., 186Lyman, C.E., 93Lynch, A.L., 22Lynch, I., 65, 72, 74, 75, 77, 78Lynd, N.A., 330–332Lynn, D.M., 5, 197

MMa, H., 204, 205, 324Ma, L., 339

Ma, N., 207Ma, X., 141Ma, X.P., 194Ma, Y., 18Ma, Y.H., 336, 344Ma, Y.X., 204, 207Mabit, H., 201Mabrouk, E., 15MacDonald, R.C., 160, 190Machemer, T., 195Macintyre, E., 172Mackay, S.P., 193Mackerell, A.D., 283MacLachlan, I., 169MacNeil, S., 15MacVinish, L.J., 173Maddox, D.A., 5Maderna, C., 189Madler, L., 77Madsen, E., 172Maeda, H., 6, 13, 319Magalhães, T., 259Magdassi, S., 60, 68Mage, R., 131Magenau, A.J.D., 346Mageswaran, P., 236Maggi, A., 194Maginn, E.J., 307Magny, B., 60Magosin, S., 172Maham, A., 322Mahan, L.C., 191Mahato, R.I., 115, 188, 194, 195Mahon, B.P., 170Maiato, H., 196Maier, M., 169Mailander, V., 77Maincent, P., 114, 116Mainwaring, M.G., 262, 263Majors, B.S., 71Mak, T.W., 259Makarsky, A., 60, 68Maki, N., 169Malda, J., 227, 246, 247Malde, A.K., 283Male, D.K., 203Malessy, M.J., 189Malgouris, C., 206Malhotra, M., 322Malik, N., 193Mallet, J., 16, 189Malloy, A., 99, 100Malmsten, M., 38, 41, 48–50, 69Malochkin, V.V., 263

Author Index 385

Malone, E., 243, 246Malone, J.G., 190Malone, P.M., 262Malone, R.W., 190Malshe, A., 227, 230, 243Mancuso, F., 141Manjunath, N., 170, 204, 205Manley, B., 243Mann, B.K., 233, 236, 239Mannisto, P.T., 194Mano, J.F., 335–337Mano, M., 158, 161, 162, 166Manoharan, M., 169Mansouri, S., 196Mansson, R., 69Mantha, V., 336Mantovani, G., 346Manzini, S., 281Manzur, F., 246Mao, C.Q., 324Mao, G., 18Mao, H.Q., 196Mapili, G., 239, 242Marcellin, P., 11Marcello, A., 189Marchesini, S., 189Marchetti, P., 134, 138Marcucci, G., 164Marczynski, B., 262Mardare, D., 326Marga, F., 244Margalit, R., 2, 4, 14, 15Margison, J., 4, 13Marianecci, C., 323Marigliano, I., 120Marignan, J., 46, 47Marín-Hernández, A., 259, 261Mark, A.E., 282–284Markwald, R.R., 226, 244Marques, D.A.S., 291Marques, E.F., 60Marquis-Weible, F., 134, 138Marrink, S.J., 284Marsch, S., 15Marsh, M., 8Marshall, J., 160Marshall, S.M., 128Marshall, W.S., 188Marson, A., 134, 135Martens, P.J., 134, 135Martin, D.S., 259, 261Martin, F., 135Martin, I., 140Martin, M., 160, 161, 190

Martin, T., 67Martinand-Mari, C., 171Martinez, E.E., 197Martinez-Arguelles, D.B., 204, 206Martinez-Fong, D., 204, 206Martinez-Veracoechea, F.J., 78Martino, S., 189Martins, I., 189Martins, M.C.L., 204, 208Martynov, A.I., 263Maruyama, A., 193Marzabal, S., 191Masson, C., 164, 199Mast, J., 118Mastrototaro, L., 259Mata, M., 189Matas, A.J., 130Mateus, M., 135Mathias, J.P., 329Mathiowitz, E., 113Matias, J.M., 232Matricardi, P., 227, 323Matsui, H., 199Matsui, M., 146Matsumura, Y., 6, 13, 319Matsunaga, T., 169Matsushita, T., 189Matteson, G.H., 60Matthews, S.E., 8Matyjaszewski, K., 325–328, 330, 332, 334,

336, 343, 346Mauer, S.M., 130Maurin, F., 323Maury, M., 208Maves, S.A., 292Mavilio, F., 173Maxfield, F.R., 9, 15, 16Maxhuni, A., 146Maxwell, D.S., 283May, C., 16Mayor, S., 8, 318Mays, J., 327Maysinger, D., 12, 330, 332, 334, 340, 341Mazarakis, N.D., 16Mazda, O., 167Mbimba, T., 204, 206McAllister, A.K., 198McBrayer, S.K., 256McBride, J.L., 204, 205McCabe, T.J., 16McCaffrey, A.P., 208McCarthy, L., 296, 306McCartney, S.J., 146McCarty, M.F., 261

386 Author Index

McClintock, K., 169McClung, W.G., 321McCluskey, A., 318McConnell, E.L., 115McCormack, M.P., 172McCormick, C.L., 334, 340McCown, T.J., 189McCoy, J.R., 4, 11, 12McCray, P.M. Jr., 189Mcdonald, M.P., 45, 46McEwan, J.F., 119McGuffie, E.M., 188McGuire, J., 11McGuire, M.J., 21McIntosh, T.J., 190McKay, T., 199McKenzie, D.L., 192McKeown, N.B., 119McKinnon, A., 120McLachlan, G., 173McMahon, H., 318McMahon, H.T., 76McMahon, M., 262McNally, D., 16McNamara, J.O. II., 208McQuarrie, D.A., 275McSwiggen, J.A., 169Meade, B.R., 157Meadows, J., 57Mecartney, M.L., 94Mechler, Á., 94Mechti, N., 10Mechtler, K., 13, 14, 16–18Medina, S.H., 194Medina-Kauwe, L.K., 165Medronho, B., 49Meeker, D., 173, 174Mehl, R.A., 346Meid, J., 59Meier, B., 2Meier, C., 5, 13, 18Meier, M., 292Meier, R., 164Meier, W., 15, 340, 343Meijer, E.W., 193Meinel, A.J., 227Meinel, L., 227Meissner, W., 202Melaaen, M., 306Melchels, F.P.W., 227, 233, 234, 236, 249Mele, G., 274Mellman, I., 8, 9, 15, 16Mello, C.C., 168, 188Mel’nikov, S., 65

Melosh, N., 60Melton, D.A., 131Mély, Y., 9Menchikov, L.G., 263Mendes, A., 228, 243Mendez, A.J., 140, 141Mendez, R., 136, 140, 141, 323Mendonca, L.S., 169, 171, 190Mendoza, C., 333Meneghini, L., 111Menez, A., 206Meng, F., 15Meng, H., 75Menon, A.K., 119Mente, P., 236Meraz, M.A., 204, 206Mercatante, D.R., 170Merdan, T., 18, 195, 321Mergan, D., 259Mergny, M.D., 14, 18, 194Mergola, L., 274Merideth, N., 136, 140, 141Merkle, H.P., 20, 227Merl, D., 261Mero, A., 343Merritt, W.M., 169Messaud, F.A., 103Messersmith, P.B., 142, 145Metters, A.T., 146Meulbroek, J.A., 117Meuler, A.J., 330–332Mewani, R., 171Meyerholz, D.K., 208Meyers, G., 190Mezzacasa, A., 8Mi Bae, Y., 195Mi, F.L., 119Miao, K., 264Michaelis, U., 173Michel, C., 117Michelakis, E.D., 256Michelini, E., 105Michielin, O., 283Mickiewicz, R.A., 333Middaugh, C.R., 157, 198Middleton, P.G., 173Midoux, P., 18, 192Mietzner, B., 256Miguel Mda, G., 162Miguel, M.G., 60–63, 65, 70Mihailescu, I.N., 236Mikkilineni, S., 246Mikos, A.G., 10, 18, 194Miles, K.A., 256

Author Index 387

Millecamps, S., 189Miller, A.D., 199Miller, B., 169Miller, D.D., 115, 195Miller, J., 130Miller, K., 21Miller, T., 259Miller, T.J., 10Millis, J.M., 141Milner, J.A., 264Milroy, D.A., 192Milton, J.G., 320Minamitake, Y., 5Minh, L.N., 146Minko, S., 332, 333, 338, 340Minko, T., 3, 6, 11, 15, 320, 334, 342Minoo-Rabeeh-Hobabi, H.D., 325Mintzer, M.A., 190, 197Minuk, G., 11Mirabelli, C.K., 191Mirasoli, M., 105Mironi-Harpaz, I., 234Mironov, V., 226, 227, 232, 244Mironov, V.F., 262, 263Mirzaei, M., 322Mishchiy, N., 306Mishra, D.N., 322Mislick, K.A., 199Mitchell, D.J., 45, 46Mitchell, G.R., 227, 232Mitragotri, S., 316, 317, 319–321Mitrophanous, K.A., 16Mitsuishi, M., 227, 230, 243Mittnacht, U., 197Miura, S., 134, 138–140Miwa, A., 12Miwa, H., 189Mix, D., 12Miyake-Stoner, S.J., 346Miyamoto, M., 141, 146Miyanishi, K., 169Miyata, T., 167Mizukami, H., 189Mizuno, M., 173, 174Mizusawa, H., 169Mo, H., 195Mo, X.M., 243Moad, G., 326Modi, R., 236Moen, R.C., 10Moezi, L., 120Mofford, K.A., 173, 174Moghimi, S.M., 23, 71Mohamed, A.J., 166, 203

Mohana Raju, K., 338Mohanty, S., 273, 292, 293Mohapatra, S., 200Mohler, J.L., 170Moldovan, A., 302Möller, L., 236Moloney, M.K., 136, 140, 141Monaco, L., 194Monck, M., 10Monfils, P.R., 170Monia, B.P., 170Moninger, T., 201Monopoli, M.P., 75, 77Monsigny, M., 18, 192Monsky, W.L., 6Montanucci, M.P., 141Montecucco, C., 207Montgomery, M.K., 168, 188Monticelli, L., 284Montier, T., 158–160, 164Moon, M.H., 103, 105Moon, S., 246Mooney, D.J., 144, 146, 227, 323Moore, J., 286Mooren, F.C., 196Moran, L.A., 21Moran Mdel, C., 162Moreira, J.N., 169, 171, 190Morel, P., 131Moreno-Sánchez, R., 259, 261Moret, E.E., 14, 18Morgan, G., 264Morgat, J.L., 206Morillon, E., 172Morimoto, M., 200Morimoto, N., 69Mori-Sánchez, P., 275, 280Morishita, R., 167Morita, I., 246Moriyama, K., 193Morizane, C., 13Mornet, E., 164Morris, G.E., 58Morris, M.C., 158Morrison, R., 3Morrissey, D.V., 169Morse, D.L., 261, 263Mortier, S.T.F.C., 302Morton, S., 308Moss, S.F., 170Moss, S.H., 192Motornov, M., 340Mott, D., 95Mou, C.Y., 76

388 Author Index

Mounkes, L.C., 199Mountain, A., 158Moynier, M., 191Mrkvan, P., 11Mueller, L., 330, 332Mueller-Klieser, W.F., 259Muhammad, O., 10Mukherjee, A., 208Mukherjee, S., 9, 15, 16Müllen, K., 322Müller, G., 110, 113, 114, 118, 119Müller, K.H., 22Muller, R.H., 75, 166Muller, S., 164Muller, T., 274, 307Müller-Buschbaum, P., 333Mulligan, R., 2Mumper, R.J., 195Mundargi, R.C., 116, 324Munkonge, F.M., 174Muoio, D.M., 261Murali Mohan, Y., 338Murali, R., 15Muramatsu, S., 189Murase, K., 169Murata, H., 346Murdter, T.E., 171Muro, K., 13Murphy, D.M., 104Murphy, M., 136, 140, 141, 322Murray, J.C., 23, 71, 188Murray, J.L., 173, 175Murray, L.S., 3Murray, M.J., 58Murry, T., 3Murthy, N., 7, 9, 11, 18–21, 69Musila, R., 3, 11Musyanovych, A., 77Muul, L., 172Myers, M.N., 103

NNabel, E.G., 190Nabel, G.J., 190Nadasdi, L., 16, 18Nafea, E.H., 134, 135Nagai, N., 322Nagano, M., 16Nagasaki, T., 200Nagasaki, Y., 165, 340Nagata, N., 141, 146Nagatomi, J., 246Nagatsu, T., 189

Nagpal, K., 322Nah, J.W., 200Nahmias, Y., 247Naidu, B.V.K., 322Naik, S.S., 339Nair, L.S., 322–324Nair, P.C., 283Nair, P.D., 135Nair, S.V., 228Naito, M., 12Najarian, J.S., 130Najm, W.I., 262Nakagawa, H., 21Nakahama, H., 13Nakahara, N., 173, 174Nakamae, K., 12Nakamu, K., 4, 19Nakamura, I., 193Nakamura, J., 21Nakamura, M., 246Nakamura, T., 21Nakano, I., 189Nakano, M., 12Nakano, M.Y., 201Nakatani, M., 200Nakayama-Ratchford, N., 343Naldini, L., 189Nallet, F., 47Nam, K., 195Nam, Y.S., 322Nan, X., 166Nannizzi, L., 207Nantz, M.H., 190Napier, M.E., 317, 318, 321Napoli, A., 15Narang, A.S., 115, 195Narayan, R.J., 236Narayana Reddy, N., 338Narendran, P., 129Nassoy, P., 15Natsume, A., 174Natu, M.V., 324Naughton, M.A., 207Naujoks, K., 173Navarro-Quiroga, I., 204, 206Nayak, S., 188Neagu, A., 226, 244Neale, E.A., 207Nechev, L.V., 169Nefedov, O.M., 262Negelein, E., 256, 259Nel, A.E., 77Nellans, H.N., 119Nelson, A., 22

Author Index 389

Neri, M., 189Netti, P.A., 146, 228Neufeld, R.J., 111, 116, 121Neumann, E., 2Neves, S., 159–162, 168Neveu, C., 164Newbury, D.E., 93Newman, C., 13Newsome, J.T., 171Ng, S.Y., 324Nguyen, C., 161Nguyen, P., 343Nguyen, S.T., 345Nguyen, T., 204, 205Ni, X., 208Nichol, J.W., 226Nickolls, J., 308Niclou, S.P., 189Nicol, F., 16–18Nicolas, J., 346Nicolas, V., 118Nicolet, P.A., 2Nicotra, A., 203Nie, S., 164Nie, X., 21Nie, Y., 200Nielsen, I.M.B., 274, 307Nielsen, L.K., 136, 138, 139, 142, 143Niemann, A., 202Nieminen, R.M., 282Nienhaus, G.U., 77Niidome, T., 21Niitsu, Y., 169Nikolaev, V.G., 261, 263Nilsson, B., 141, 143Nilsson, H., 75Nilsson, M., 196Nilsson, P.M., 68, 128Nilsson, S., 60, 62, 63, 68Nir, S., 5, 16, 161, 162Nishida, K., 21Nishina, K., 169Nishiyama, N., 12, 340Nishizawa, M., 322Niven, R.W., 161Niwa, H., 262Nizri, G., 60, 68Njoki, P., 95Nobayashi, M., 173, 174Noble, M.L., 324Noel, D., 170Noguchi, T., 322Noguchi, Y., 6

Nolta, J.A., 172Nolte, R.J.M., 15Nopens, I., 302Norrman, J., 67Norsten, T.B., 332Northrop, J.P., 14, 158, 190Nostro, M.C., 131Nothias, J.M., 141Nottelet, B., 333Novoa-Carballal, R., 204Nozawa, M., 141, 146Nunes, A., 197Nunes, F., 172Nunez-Alonso, G., 174Nusbaum, P., 172Nyangoga, H., 324Nyquist, C., 282Nyström, B., 56, 60, 68

OOberhauser, B., 13, 14, 16–18Oberholzer, J., 131Oberling, F., 199O’Brien, T., 322O’Brodovich, H., 10Ochiai, K., 261Ochiai, Y., 21Ochoa, I., 204, 206Ochs, R.S., 21Oda, T., 262Odde, D.J., 247Odoh, S.O., 292Ogawa, O., 322Ogris, M., 14, 18, 194, 195, 200Oh, C., 323Oh, I.J., 12, 200Oh, J.K., 332–334, 343Oh, Y.K., 194O’Halloran, T.V., 345Ohashi, S., 167Ohba, S., 263Ohkuma, S., 200Ohri, L.K., 262Ohri, S., 245Ohtomi, M., 69Ohuchi. K., 246Oishi, M., 165Okabe, S., 189Okada, T., 189Okado, H., 189Okahata, Y., 196Okano, T., 12, 13

390 Author Index

Okawa, A., 189Okubo, M., 326Okusaka, T., 13Olea, D., 49Oliveira, H., 196, 197, 204, 208Oliveira, L.M., 239Oliviero, O., 146Olsson, R., 146Olsson, U., 44, 46Olthuis, W., 227Oltvai, Z.N., 256Olvera de la Cruz, M., 70Onaca, O., 340, 343Oner, F.C., 227Ong, W.L., 321Ong, Z.Y., 321Oostenbrink, C., 282, 283Oosting, R.S., 202Opalinska, J.B., 157Oramas, E., 193O’Reilly, R.K., 339, 342Orlacchio, A., 189Orlando, F., 324Orlean, P., 119Orlov, A., 261Orlova, M., 261Orlowski, A., 293Ortiz, V., 15Osaki, F., 76Osanai, S., 4, 19Osborne, C.S., 172Osetinsky, I., 164, 199Oshikawa, Y., 262Oshima, S., 262Osta, R., 208Osticioli, L., 136Ostlund, N.S., 275Ota, N., 261Othon, C.M., 245–249Otsuka, S., 186Otte, T., 103Ottenbrite, R.M., 322, 324Otu, H., 259Oudshoorn, M.H., 233, 244, 245Oupicky, D., 194, 198Ovsianikov, A., 236Owens, D.R., 113Owens, J., 308Ozaki, M., 262Ozawa, K., 189Ozbas-Turan, S., 197Ozeki, M., 322Ozmen, L., 143

PPace, A., 118Pack, D.W., 2–5, 7–10, 13, 14, 18, 19, 71,

321Padmabandu, G., 2Pagano, R.E., 8, 318Paige, C., 16Paiva, A., 166Pakade, Y.B., 324Pakula, T., 327Pakunlu, R.I., 15, 342Palczuk, N.C., 4, 11, 12Palliser, D., 170Palmer, J.A., 189Palmer, L.R., 169Palu, G., 189Pamies, R., 56Pan, C., 333Pan, S., 264Pan, Y., 246Pan, Y.G., 323Panchagnula, R., 59, 118Pande, V.S., 308Pandey, R., 75Pandit, A., 322Pang, Z., 204, 205, 208Pansky, B., 115Pant, K., 300Panyam, J., 10, 200Paolicelli, P., 323Papadakis, C.M., 333Papahadjopoulos, D., 14, 15, 162, 199Papapetropoulos, A., 16Papon, E., 338Pappenheimer, J.R., 119Paradellis, T.P., 259Pardo, L., 243Pardridge, W.M., 163, 203, 204Paredes, E., 346Parente, R.A., 16, 18Parish, W.W., 262Park, A., 243Park, H.J., 171Park, H.Y., 95Park, I.K., 9, 200, 204, 208Park, I.Y., 200Park, J.H., 4, 6, 7Park, J.-H., 243, 244Park, J.K., 21, 22Park, J.-K., 246Park, J.M., 333Park, J.S., 4, 6, 7, 193–195, 197Park, J.Y., 4, 6, 7, 195

Author Index 391

Park, K., 18Park, M.V., 264Park, S., 346Park, S.N., 200Park, T.G., 12, 13, 200, 204, 205Park, Y.S., 21Parkman, R., 172Parks, D.A., 208Parks, S.K., 261Parthasarthy, R., 15Parton, R.G., 8, 76, 318Pasch, H., 103Pasenkiewicz-Gierula, M., 293Pasparakis, G., 335, 339Pasqualini, R., 319, 320Pastorino, L., 322Pasumarthy, M.K., 10Pasut, G., 11Patai, S., 263Patapoutian, A., 207Patel, D.J., 187Patel, N., 113Patel, P., 116, 324Patel, R., 324Patel, S., 283Pathak, Y., 274Patil, R., 204Patil, S., 95Patrício, T., 226, 227, 232Paulson, A.T., 322Paulus, W., 193Paun, I.A., 302Pauwels, E.K., 256Pawliuk, R., 172Pawlyn, C., 19, 21Payne, J.M., 10Payne, J.Y., 173, 175Peck, K., 207Pecora, R., 95, 98Pedersen, P., 256Pedroso de Lima, M.C., 157–162, 165, 166,

168–171, 190, 191, 200, 204Peeler, J.C., 346Peer, D., 2, 4, 14, 15Peeters, P.J., 189Pêgo, A.P., 193, 195–197, 204, 208Pei, J., 171Pei, Y., 204, 205Pei, Y.Y., 200, 204, 205Pelicano, H., 259, 261Pelisek, J., 195Pelkmans, L., 8Pelta, J., 70Peltola, S.M., 233, 249

Penacho, N., 158, 161, 162, 200Pender, A., 343Peng, K., 227Peng, L., 338Peng, S.F., 18Peng, Y., 200Peniche, C., 322, 323Peniche, H., 322, 323Penn, R., 306Pennadam, S., 340Penny, J., 119Peppas, N.A., 2, 3, 111, 229, 335Peppas, N.a., 301Peracchina, M.T., 5Pereira, A.J., 196Pereira, R., 228Perez, M.C.P., 189Periole, X., 284Perozzi, G., 120Perricaudet, M., 16, 189Perriello, G., 112Perrier, S., 328Perriere, N., 203Perron, H., 199Peschanski, M.R., 189Pescosolido, L., 227Peteanu, L., 332, 334, 343Petereit, H.U., 5, 13, 18Petersen, H., 194, 195Peterson, C.W., 261Peterson, D.A., 189Pethica, B.A., 60Petrak, K., 2Petros, R.A., 317, 319–321Petrovan, S., 282Petrus, A., 119Petsko, G.A., 292Pfeifer, A., 158Pfeiffer, A.F., 256Pfeiffer, W., 40Pfisterer, M., 15Pfutzner, A., 113Pham, P.T.K., 262Phelps, J.R., 169Philippe, J., 131Phillips, D.R., 207Phillips, E., 308Phillips, G.O., 57Phillips, J., 173, 174, 308Philo, J.S., 104Photos, P., 15Piacenti da Silva, M., 259Piao, L., 164Picci, N., 274

392 Author Index

Pichon, C., 192Piculell, L., 56, 60–65, 67, 68Pierrefite-Carle, V., 168Pietrasik, J., 336Pietrzynski, G., 13Pietsch, T., 333Pilch, P., 318Pillai, O., 59, 118Pillai, R., 2Pinget, M., 135Pintauer, T., 327, 328, 343Pinto, E.M., 239Pinto Reis, C., 111Pinto-Alphandary, H., 118Piontek, G., 164Piotrowska, K., 171Pippenger, B., 247, 248Pirart, J., 186Pires, L.R., 196, 204, 208Pires, P., 157, 158, 161, 162, 165, 191Pirie, C.M., 20Pirollo, K.F., 164Pirsch, J.D., 130Piskin, E., 18Pitsikalis, M., 327, 342Pittner, F., 119Pizzorusso, T., 197Plank, C., 13, 14, 16–18, 166Plapied, L., 119Plesnila, N., 163, 164, 170, 204Plichta, A., 330Pockros, P.J., 11Poellinger, K.A., 201Poenaru, L., 189Poger, D., 283, 284Pohl, J., 9Pohl, T., 2Poletti, M.E., 259Polisky, B.A., 169Pollard, H., 201Pollard, R.B., 263Polmar, S.H., 11Polushkin, E., 333Polverino de Laureto, P., 207Poncelet, D., 245Ponchel, G., 118, 324Pongracz, K., 16, 18Pontes, A.V., 232Pontoglio, A., 256, 259Pool, C.W., 189Poole, B., 3, 200Poole-Warren, L.A., 134, 135Poor, C., 262, 263Popa, J., 256

Popescu, C., 59Porcellati, F., 112Porporato, P.E., 257, 259Porte, G., 46, 47Porteous, D.J., 166, 173, 174Portilla-Arias, J., 204Posener, K., 256Poste, G., 14Pot, M.W., 246, 247Potineni, A., 5Poulain, B., 207Pouton, C.W., 2, 8, 192Pouyssegur, J., 259, 261Prabaharan, M., 228Prabha, S., 200Prabhakarpandian, B., 300Prakash, S., 322Prank, U., 201Praprotnik, M., 275Prat, C., 16Pratesi, G., 281Prato, M., 197Pratten, M.K., 8, 199Préat, V., 118, 119Prencipe, G., 343Press, O.W., 20Prevot, P., 171Price, D.L., 207Prikhodko, S., 94Primack, A., 262Pringle, I.A., 174Prinz, C., 172Prokop, A., 131, 132Prompruk, K., 21Propert, K.J., 172Propst, K.L., 168Provder, T., 88, 103Provencher, S.W., 98Pruitt, S.R., 276Pryor, P.R., 9Pun, S., 321Pun, S.H., 2–5, 7–10, 13, 14, 18, 19, 195, 204,

208Puoci, F., 274Puri, R., 200Purohit, C.S., 200Pusch, O., 170Putnam, D., 71, 195, 197Putnam, J.B., 173, 175

QQi, R., 328Qi, Z., 141

Author Index 393

Qian, Z., 324Qiao, W., 190, 197Qin, S., 342Qiu, J., 325, 326Qiu, L., 324Qu, Y.H., 200, 204, 205Quach, E.T., 189Quadir, M.A., 340, 343Quaglia, F., 228Quate, C.F., 93Quattrini, A., 189Queiroz, J.A., 323Quijano, E., 195Quiñoá, E., 204Quinones-Hinojosa, A., 197

RRaasmaja, A., 194Rabbitts, T.H., 172Rabinovich, P., 191Racanicchi, L., 141Rachmawati, R., 333Racie, T.S., 169Racker, E., 256Radford-Weiss, I., 172Radler, J.O., 14, 161Radosz, M., 194, 332, 340Rafiee-Tehrani, M., 120, 285, 286Rafiei, P., 196, 228Raghunand, N., 261, 263Rahbek, U.L., 197Raimundo, J.M., 194Raisanen, J., 194Raisin, J., 262Rait, A.S., 164Rajeev, K.G., 169Rajotte, R.V., 130, 141, 147Rajurkar, K., 227, 230, 243Rajwanshi, V.K., 187Rakhmanova, V.A., 160, 190Ramani, K., 16Ramesan, R.M., 116, 118Rampersaud, A.A., 135Ramratnam, B., 170Ramsey, P., 160, 161, 190Ranaldi, G., 120Randell, S.H., 199Ranganathan, P., 10, 166, 202Rangaswamy, V., 116, 324Ranger, M., 12Ranson, M., 4, 13Rao, M., 318Raof, N.A., 247

Raper, S.E., 172Rappoport, Z., 263Raspaud, E., 70Ratanathanawongs Williams, S.K., 103Ratcliff, R., 173Rathmann, W., 128Ratner, B.D., 324Raviña, M., 323Ravindra, S., 338Rawn, J.D., 21Ray, J.G., 339Rayat, G.R., 147Reach, G., 141Read, E.S., 334Read, M.L., 193, 204, 207Read, T., 169Reddy, J.A., 164, 199Reddy, K.R., 11Redemann, C.T., 18, 193Reeder, R.C., 284Rees, G.D., 50Regan, F., 262Régina, A., 204, 205Rehor, A., 141Reichardt, L.F., 207Reichelt, S., 343Reimers, M., 306Reindollar, R.W., 11Reis, C.P., 114, 116Reis, N., 243Rejmanová, P., 9Remon, J.P., 302Remy, J.S., 190, 196, 201Rémy, M., 247, 248Rémy-Kristensen, A., 9Rende, M., 207Renn, M.J., 247Rensch-Boschert, K., 256Reppen, T.W., 9Reschel, T., 194Reschiglian, P., 105Resina, S., 166, 171Reslow, M., 301Resnick, M., 170Restle, T., 157, 170Reszka, R., 173, 176Rettig, H., 346Rexach, M., 10Reynolds, A., 188Rezende, R.A., 243Ribeiro, A.J., 111, 112, 116Ribeiro, C.A., 324Ribeiro-Silva, A., 259Rice, K.G., 192

394 Author Index

Richard, J.P., 171Richards, A.A., 76Richards, J., 173, 175Riches, J., 318Richter, D., 40Richter, R., 173, 176Richtering, W., 58, 59Rickus, J., 282Ridoux, V., 16Riguera, R., 204Ríhová, B., 11Rijkers, D.T., 135Rimmer, S., 12Ringe, D., 292Ringeisen, B.R., 245–249Ringland, S.E., 143Ringold, G.M., 5, 14, 158, 190, 191Ringsdorf, H., 3, 8, 10, 12, 199Risselada, H.J., 284Ristow, M., 256Ritman, E.L., 233Rivella, S., 16Rives, C.B., 144Rivron, N.C., 226Rizzardo, E., 326Rizzo, M.A., 191Robbins, I., 171Robbins, P.D., 158Robert, J.J., 16Roberts, C.J., 245Roberts, D., 259Roberts, J.C., 193Roberts, W.G., 6Robertson, R.P., 130Robey, I.F., 261, 263Robichaud, J.R., 20Robinson, M.B., 172Robinson, P.J., 318Rochlitzer, S., 186Roda, A., 105Roda, B., 105Rodal, S.K., 8Rodríguez-Enríquez, S., 259, 261Rodríguez-Hernández, J., 329–331, 334,

338, 343Roe, D.J., 261, 263Roesch, P.L., 9Roessler, B.J., 189Róg, T., 293Roger, E., 118, 119Rohl, I., 169Roig, A.R., 98Roiter, Y., 332, 333, 338, 340Rolland, A., 2

Rolland, A.P., 188, 195Roman, R., 14, 158, 190Romana, S., 172Romanos, A.N., 259Romero, I.A., 203Romig, A.D. Jr., 93Roose, D., 282Rose, J.W., 207Rosen, H., 272Rosen, S.T., 256Rosenberg, E., 262Rosenecker, J., 166Rosenzweig, H.S., 160, 190Ross, P.C., 191Ross, R., 273, 292, 293Rossetti, P., 112Rossetto, O., 207Rossi, J.J., 208Rossi, O., 56Rossodivita, M.E., 136Rostovtsev, V.V., 328Rotello, V.M., 197, 332Roth, C.M., 195Rothermundt, M., 262Røtnes, J., 306Rouhanipour, A., 322Rouiller, I., 333Rouwkema, J., 226Roux, E., 4Roux, F., 203Roux, P.P., 207Rowinsky, E.K., 13Roy, D., 334, 335, 338Roy, K., 196, 239, 242Royaux, I., 189Rozema, D.B., 9Rubinstein, M., 55Ruchusatsawat, K., 259Rudelius, M., 164Rudin, A., 103Rudolph, C., 166Rudzinski, W.E., 323Ruggeri, Z.M., 245, 246Ruggiero, C., 322Rumenapf, T., 190Runborg, O., 273Runyon, J.R., 103Ruponen, M., 198, 199Rush, R.A., 204, 207Russell, A.J., 346Russell, P., 95Russell-Jones, G.J., 119Ruys, L., 332Ryan, A.J., 15, 55

Author Index 395

Ryan, E.A., 130, 141Ryan, K.J., 55, 202Ryan, T.A., 200

SSaam, B., 201Saam, J., 308Saavedra, E., 259, 261Saba, N.F., 164Saba, V., 324Sachlos, E., 243Sackmann, E., 40Sadeghi, A.M., 120Sadelain, M., 16Sadhale, Y., 49Saf, R., 233Saffran, M., 115Safinya, C.R., 14, 161Sahay, G., 317, 318Sahoo, S.K., 324Saimoto, H., 200Saini, R., 335–337Saison-Behmoaras, T.E., 194Saito, R., 173, 174Sajeesh, S., 286Sakai, K., 13Sakamoto, K., 167Sakhno, L.A., 261, 263Sakloetsakun, D., 118Sakowski, S.A., 186Sakthivel, T., 193Sakurai, Y., 12, 13Salabas, E.L., 343Salamat-Miller, N., 119Salditt, T., 14, 161Saliez, A., 141Salmela, K., 141Salter, E., 323Saltik, M., 10Saltzman, W.M., 7Salvage, J.P., 344Salvati, A., 72, 75, 77, 78Sambuy, Y., 120Sami, H., 346Sampaio, P., 196Samuel, J., 3, 12, 13Samulski, R.J., 189Samways, J., 173San, H., 190Sanchez, A., 75, 323Sanchez, J., 141Sanchis, J., 21Sancho-Pelluz, J., 189

Sanderson, R.D., 103Sandford, P.A., 136, 140, 141Sando, S., 76Sandri, T., 245Sandvig, K., 8Sang Park, J., 195Sankar, V., 186Sant, V., 341, 342Santerre, J.P., 321Santos, J.L., 193Saple, D.G., 264Sarasij, R.C., 318Sarchielli, P., 136Sargon, M.F., 204Sarkar, D., 259Sarkar, D.P., 16Sarmento, B., 121Sarnatskaya, V.V., 261, 263Sartelet, H., 205Sasaki, H., 21Sasaki, K., 262Sasaki, T., 204Sassano, D., 245Sat, Y.N., 3, 11Satake, A., 146Satchi, R., 3, 11Satchi-Fainaro, R., 21Sato, H., 104Sato, K., 229Sato, T., 169, 196, 200Sato, Y., 169Satoh, E., 167Satoh, T., 200Sattler, U.G., 259Sauer, T., 10Saunders, B.R., 58Saunders, R.D., 243Saunders, R.E., 246Sauter, S.L., 189Savic, R., 12Savin, D.A., 339Savitt, J.M., 208Saw, C.L., 15Sawa, T., 13Sawamoto, M., 326Sayir, F., 259Sazani, P., 170Scalise, G., 324Scallan, M., 173, 174Scamehorn, J.F., 60Scanlon, P.H., 128Scarborough, R.M., 207Scardino, A., 274Scaringe, S., 188

396 Author Index

Scatena, R., 256, 259Scavone, A., 141Schacht, E., 11, 227, 228Schadt, M.J., 95Schaefer, U., 171Schaffer, D., 189Schaffner, T., 262Scharringhausen, T., 120Schatz, G.C., 294Schatzlein, A., 192, 193Schatzlein, A.G., 119, 190, 192–194Schätzlein, A.G., 11Schauss, A., 262Schelue, R.K., 160Schenkman, S., 165Scherman, D., 14, 18, 164, 170, 194, 199, 202Scherrer, P., 16Schiavo, G., 207Schiele, N.R., 247Schild, H.G., 13, 336Schillen, K., 61Schillinger, U., 166Schlachetzki, F., 203Schlichting, I., 292Schlick, T., 282Schlosshauer, B., 197Schluep, T., 195Schmaljohann, D., 335, 336, 338Schmandt, R., 169Schmehl, M., 136, 140, 141Schmidt, B., 12Schmidt, G.A., 261Schmidt, J., 60, 68Schmidt, M., 172Schneider, D., 146Schneider, H., 204, 208Schneider, J.P., 339, 340Schneider, S., 68Schneider, Y.-J., 118Schnettler, R., 138Schoen, P., 16Schoenenberger, G.A., 264Scholte, B.J., 202Schramm, L.L., 38Schreckenbach, G., 292Schroeder, H.A., 262Schubert, P., 256Schubert, U.S., 328Schuck, S., 69Schuewer, N., 328Schuller, S., 194Schulte-Herbruggen, O., 186Schulten, K., 281, 282, 307, 308

Schulz, N.D., 61Schulz, T.J., 256Schuster, M., 233Schuth, F., 343Schüttelkopf, A.W., 283Schuurman, W., 246, 247Schuurmans-Nieuwenbroek, N.M.E., 14, 18Schuurs, T.A., 140, 142, 143Schwartz, J., 286Schwartz, L., 259Schwartz, M.K., 259Schwartz, R.E., 247Sciascia, S., 189Scínska, A., 256Scorrano, S., 274Scott, J.E., 60Scoutaris, N., 245Scrimgeour, K.G., 21Scudiery, D., 11Seal, S., 95Searle, F., 3, 11Sebak, S., 322Sébastian, C., 323Sebestyen, M.G., 202Séchoy, O., 323Seck, T.M., 234, 236Seeber, S., 173Segovia, J., 206Segrest, J.P., 18Seiffert, S., 169Seijo, B., 323Seiler, C., 2Seixas de Melo, J., 61Seki, K., 15, 19, 20Sekimoto, R., 262Seksek, O., 201Seliktar, D., 234Selz, F., 172Semenov, A.N., 58Senderowicz, A.M., 259Senff, H., 58Sengillo, J.D., 189Seno, A., 262Seo, H.J., 194Seol, Y.-J., 234Seong, A., 346Sera, T., 76Serganov, A., 187Serikawa, T., 190Sessa, M., 189Sessa,W.C., 16Seto, C.T., 329Sevo, M., 324

Author Index 397

Seyfried, T.N., 256Seymour, L.W., 2, 5, 11, 193, 194, 198,

204, 207Sezer, A.D., 197Shaffer, C.S., 169Shah, D.S., 193Shah, J.C., 49Shai, Y.C., 18Shakweh, M., 118Shakya, A.K., 346Shalaev, E.Y., 22Shankar, P., 170, 204, 205Shanmugam, M., 256Shanmugam, S., 169Shao, K., 204–206Shapiro, A.M., 130, 141Sharma, C.P., 116, 118, 286Sharma, P., 318Sharma, R., 18, 202Sharpless, K.B., 328Shaw, L., 169Shcherbinin, V.V., 263Shea, L.D., 141, 143, 144Sheehan, M.A., 15Sheena, N., 264Sheff, D., 9, 16Sheikh, S., 169Sheiko, S.S., 55Shelley, J.C., 284Shelley, M.Y., 284Shen, M.C., 300Shen, M.J., 22Shen, T.T., 324Shen, Y.Q., 194, 332, 340Sheng, K.L., 200Shenhar, R., 332Shenkman, S., 165Shenkov, S., 61Sheppard, D.N., 174Sherwood, G., 332, 334, 343Shi, J., 274Shi, K., 332Shi, L., 332, 339Shi, N., 203, 204Shi, S., 324Shi, Y., 344Shiang, Y.C., 321Shiau, C.Y., 190Shibata, M., 189Shichibe, S., 12Shiffman, M.L., 11Shigemasa, Y., 200Shigemoto, T., 326Shigeoka, A., 172

Shih, A.Y., 281, 282Shim, M., 343Shimada, N., 193Shimada, Y., 13Shin, C.S., 322Shin, D.M., 164Shin, H.R., 264, 322Shin, J.Y., 194Shin, S.C., 12, 200Shin, U.S., 243, 244Shin, V.Y., 256Shin, Y.M., 322Shinitzky, M., 15Shinkai, S., 200Shinoda, W., 282Shinohara, T., 16Shinohara, Y., 191Shinomiya, K., 189Shirao, K., 13Shirinzade, H., 324Shiryaev, V.I., 263Shoemaker, J.E., 191Shretting, G., 8Shrivastava, P.K., 323Shrivastava, S.K., 323Shu, S., 21Shuai, X.T., 200Shukla, S.K., 316, 335–337Shy, M.E., 186Siebers, U., 138Siegbahn, A., 143Siegwart, D.J., 334, 343Sig Choi, J., 195Sigal, R.J., 129Sigaux, F., 172Silbermann, R., 170Silva, A.I., 135Silva, A.S., 261, 263Silva, C.M., 112Silva, D., 324Silva, E.A., 144, 146, 323Silva, G.A., 71Silva, J., 227, 230, 243Silva, M.R., 286, 290Silver, M., 259Simakova, A., 346Simanek, E.E., 190, 197Simari, R.D., 190Simmet, T., 77Simoes, H., 172Simões, P.N., 286, 290, 291Simões, S., 157–166, 168–171, 190, 191, 196,

200, 204, 208Simons, K., 8

398 Author Index

Simpson, F., 318Simpson, J.C., 77Simpson, J.S.A., 262Singh, B., 324Singh, K., 256Singh, S.K., 322Singha, K., 204, 205Singhal, A.B., 198Sinha, V.R., 324Sioud, M., 170Sirlin, C., 190Sírová, M., 11Site, L.D., 275Sjöström, J., 60, 65, 68Skene, K., 120Skouri, M., 47Sky-Peck, H.H., 259Slater, N.K.H., 16, 18, 19, 21, 22Slaughter, B.V., 2, 3, 335Slepushkin, V., 158, 165Sligar, S.G., 292Slipchenko, L.V., 276Sloane, B.F., 261, 263Slowing, I.I., 197Smart, J.D., 118Smillie, T.J., 262Smit, J.A.M., 55Smith, A.E., 173, 174, 334Smith, C., 135Smith, C.I., 166, 195, 203Smith, D., 12, 341, 342Smith, G., 120Smith, J.G., 161, 198Smith, L.C., 188, 199Smith, L.J., 283Smith, M., 120Smith, S.J., 200Smith, S.N., 173, 174Smith, T.J., 195Smogorzewska, E.M., 172Smyth, C.A., 143Smyth, S.E., 173, 174Sneige, N., 173, 175Snezhkova, E.A., 261, 263Snowden, M.J., 58Snyder, B.R., 189Snyder, F.F., 172Soares, T.A., 283Soares, T.a., 283Sodeik, B., 201Sohn, K.J., 10Solzhenitsyn, A., 257, 264Somasundaran, P., 77Somia, N., 157, 158, 188

Sommerdijk, N.A.J.M., 15Son, S., 204, 205Sonaje, K., 116, 119Sonavane, G.S., 281Sonawane, N.D., 13Song, D.K., 189Song, E.W., 324Song, W.J., 344Song, Y.S., 246Sonveaux, P., 257, 259Sood, A.K., 169Sood, V., 169Soon-Shiong, P., 136, 140, 141Sorensen, D.R., 170Sorensen, R.U., 11, 172Sorgi, F.L., 173, 174Soria, M.R., 194Soulier, J., 172Soumetz, F.C., 322Souquet, A., 247, 248Sousa, F., 323Sousa, J.J., 115Southern, K.W., 173, 174Soutschek, J., 169Soyez, H., 11Spain, S.G., 321Spargo, B.J., 245–249Spector, M., 256Speicher, L., 172Spindler, R., 193Spitali, M., 11Springate, C.M., 197Sprous, D., 283Spugnini, E.P., 261Squire, J., 10Sridhar, C.N., 160, 161, 190Srinivas, G., 15Srivastava, A., 346Staas, J.K., 117Stabler, C.L., 144, 145Staiger, W., 256Stamm, S., 170Stampfl, J., 233Staniforth, J.N., 113Stanimirovic, D., 205Stankovics, J., 200Starostina, N., 94Stassi, G., 256Stayton, P.S., 2–5, 7–11, 13, 14, 18–21, 321Steenberghe, M., 141Steffan, A.M., 196, 199Steidler, A., 256Steil, G.M., 140Stein, C.S., 189

Author Index 399

Steinberg, P., 256Steiner, C.A., 60, 68Steinlein, P., 200Stellacci, F., 319–321Stepanek, P., 98Stephan, D.J., 190Stephens, S., 11Stepniewski, M., 293Stern, M., 173, 174Stern, P.J., 323Sternberg, B., 162Sternberg, L.R., 189Stetefeld, J., 292Stevenson, B.J., 173Stewart, J.J.P., 276Stigler, J., 74Stigsson, L., 56Stintz, M., 89, 90Stock, A.M., 292Stock, S.R., 144Stockdale, K.R., 208Stocks, A., 207Stokes, A.L., 346Stokke, B.T., 197, 202Stokkel, M.P., 256Stolnik, S., 5, 18, 21Stolz, D.B., 162, 198Stone, J., 308Stone, J.E., 307, 308Stoppa-Lyonnet, D., 172Storm, G., 227Stratford-Perricaudet, L.D., 16, 189Straubinger, R.M., 15Strey, R., 44Stroet, M., 283Strohalm, J., 5, 6, 11Strubbe, J.H., 141Strumia, M., 340, 343Stucky, G.D., 60Stupp, S.I., 58Sturm, E.J., 256Sturm, V., 173, 176Su, C.J., 18Su, D.H., 204, 208Su, J., 142, 145Su, L., 208Subashini, M., 281Subbarao, N.K., 16, 18Subileau, E.A., 203Šubr, V., 6, 11Subramanian, A., 10, 166, 202Sudhakar, M., 135Sudheesh Kumar, P.T., 228Sudheesh, N., 264

Sudimack, J., 164Sugai, K., 261, 263Sugano, N., 261Suh, D., 194Suhali, G., 239, 242Suk, J.S., 118Sumerlin, B.S., 328, 334, 335, 338Sumi, S., 131, 132, 141Sumner-Jones, S.G., 174Sun, A.M., 132, 140, 141Sun, G., 196Sun, H., 187Sun, T.M., 324Sun, W., 246, 247Sun, W.H., 2Sun, X., 164Sun, X.L., 144, 145Sun, X.Q., 323, 332, 343Sun, Y., 141, 159Sunamoto, J., 12Sundaram, S., 195Sung, H.W., 4, 18, 116, 119Sung, J.J., 256Sung, Y.K., 194Sunshine, J.C., 197Supino, R., 281Surjushe, A., 264Sutariya, V., 204, 206Suter, N., 245Sutherland, D.E., 130Sutlu, T., 165Sutter, K.A., 323Suzen, S., 324Suzuki, F., 263Suzuki, N., 190Suzuki, T., 203Svensson, A., 67Svingen, R., 70Swaan, P.W., 318Swanson, J.A., 318Sweet, R.M., 292Sweigard, J.H., 189Symonds, P., 71Syrovets, T., 77Szabo, A., 275Szewczyk, A., 71Szilagyi, A., 338Szoka, F.C. Jr., 13, 14, 16–18, 191, 193

TTa, H.T., 323Tabakman, S., 197Tabakman, S.M., 343

400 Author Index

Tabata, Y., 141, 146, 322Tacken, P.J., 321Tadele, T.S., 227Tadros, T.F., 38, 41, 46Tae Kim, Y., 195Taetz, S., 171Tahara, H., 158Takada, K., 169Takagi, F., 246Takahashi, S., 229Takahasi, K., 261, 263Takakura, Y., 188Takatani, S., 246Takayama, T., 169Takayanagi, Y., 262Takayasu, Y., 259Takemoto, N., 144, 145Takeuchi, A., 262Takeuchi, M., 167Takigawa, D.Y., 15, 19, 20Takigawa, S., 261Takimoto, R., 169Talmon, Y., 60, 68Talsma, H., 18, 19Tammi, M., 199Tamura, H., 228Tan, P., 20, 169Tan, S.W., 77Tan, W., 208, 338Tanaka, K., 190Tanaka, R., 57Tanase, D., 208Tanford, C., 40Tang, B.C., 118Tang, C., 321Tang, H.D., 194Tang, J.B., 194Tang, L.Y., 344Tang, M.X., 14, 18, 193Tang, R., 164Tang, S., 164Tang, X.H., 75Tang, Y., 336, 342, 344Tang, Z., 322Tani, T., 261, 263Tannemaat, M.R., 189Tannous, B.A., 186Tao, S.H., 262Tao, S.L., 324Tao, X., 243Tateyama, Y., 292Tautz, N., 190Tavano, L., 56Tavassoli, M., 22

Tavitian, B., 191Tavri, S., 164Taylor, D.L., 201Taylor, H.E., 104Taylor, R.C., 262Tazelaar, J., 172Tazi, J., 170ten Brinke, G., 333Tenchov, B., 160Teng, D., 21Tenga, Q.S., 208Tennant, D.A., 259, 263Teo, C.S., 299, 305Teoh, S.H., 243Teramura, Y., 131, 134–136, 138–141,

143–146Terán, L., 140, 141Ternullo, M.P., 256Terrazzino, S., 191Tetley, L., 119, 120, 192, 193Tewari, M., 320Thalberg, K., 65Thang, S.H., 326Thanou, M., 196Thanou, M.M., 120Thassu, D., 274Thayer, J.S., 263Theate, I., 118Theriault, R.L., 173, 175Therien, M.J., 15Thiel, H.J., 190Thiel, K.W., 208Thierbach, R., 256Thierry, A.R., 171, 191Thies, C., 61Thng, Y.X., 69Thoma, L., 115Thomas, A., 60Thomas, B.J., 192Thomas, C.E., 2, 16Thomas, E.L., 333Thomas, G.S., 208Thomas, J.B., 282Thomas, J.K., 63Thomas, J.L., 15, 19, 20Thomas, M., 194Thompson, C.J., 120Thompson, J.A., 143Thompson, M., 77Thomson, A.H., 3Thornton, J., 95Thrasher, A.J., 172, 173Threadgill, M.D., 8Thuillier, V., 202

Author Index 401

Thulin, E., 75Thuresson, K., 60, 62, 63, 68Tian, J.Y., 323Tian, L., 342, 343Tian, S., 321Tibell, A., 141Tice, T.R., 117Tiddy, G.J.T., 45, 46Tieke, B., 59Tieleman, D.P., 284Tighe, B.J., 21Tighiouart, M., 164Timko, B.P., 274, 339Timmins, N.E., 136, 138, 139, 142, 143Tinsley, R., 204, 207Tirado-Rives, J., 283Tirella, A., 245Tirelli, N., 15Tirrell, D.A., 13, 15, 19, 20Tissié, G., 323Titomanlio, G., 324To, H., 21Tobolsky, A.V., 56Tobyn, M.J., 113Todryk, S.M., 170Toeller, M., 129Togawa, H., 12Tojeira, A., 228Tokarev, I., 340Tomalia, D.A., 193Tomas, H., 193Tomatsu, I., 227Tonali, P., 207Toner, M., 320Tong, G., 207Tong, R., 345Too, H.P., 204, 207Torchilin, V.P., 4–6, 12, 14, 15, 48, 55, 157,

171, 198Torlone, E., 112Tortoioli, C., 136Tosi, J., 189Totani, T., 134, 138, 140, 144, 145Toth, E., 130, 141Toth, I., 193Toudjarska, I., 169Touma, M., 141, 146Trabulo, S., 166, 171Tracy, T.S., 262Tran, C.L., 90Trau, M., 136, 138, 139, 142, 143Travo, A., 171Trehan, A., 324Trezise, A.E., 173

Tricoire-Leignel, H., 203Trinquand, C., 323Triponez, F., 131Trivedi, N., 140Tron, K., 77Trono, D., 189Tros de Ilarduya, C., 159Trouet, A., 3, 200Troung-Le, V.L., 196Trowsdale, J., 164Troyer, R.M., 168Trubetskoy, V., 5Truckenmüller, R., 226Trudeau, L.E., 206Truhlar, D.G., 276, 282Trushule, M.A., 263Tsai, C.Y., 77Tsai, R., 320Tsai, Y.J., 160, 161, 190Tsai, Y.Y., 77Tsang, S.H., 189Tsarevsky, N.V., 325–328Tscharnuter, W.W., 103Tseng, W.C., 162, 198Tsitsilianis, C., 332, 333, 338Tsui, J., 262Tsuji, Y., 13Tsumoto, K., 104Tsyb, A., 259Tu, C.S., 77Tubulekas, I., 196Tucker, E.E., 60Tucker, S.D., 173, 175Tufveson, G., 141Tulkens, P., 3, 200Turan, R., 89Turecek, C., 233Türk, M.J., 18, 199Turner, D.E., 189Turner, J.J., 171Turowski, P., 203Tuschl, T., 168Tuzova, M., 324Twelves, C., 3Tyrrell, Z.L., 332, 340Tzeng, S.Y., 197Tzeng, T.-R.J., 248

UUchegbu, I.F., 119, 120, 190, 192–194Uchiyama, Y., 261, 263Uduehi, A.N., 192Ueng, S.H., 343

402 Author Index

Ueno, H., 13Ueno, N.T., 173, 175Ufimtsev, I.S., 307, 308Ulbrich, K., 4, 6, 11, 194, 198Ulery, B.D., 322–324Ulick, D., 164Unakar, N.J., 262Underhill, D.M., 317Unga, J., 68Ungaro, F., 228Unno, T., 169Urtti, A., 198, 199, 293Utkov, H., 274, 275

VVacanti, J.P., 226Vacek, I., 141Vacha, R., 78Vaidya, A., 286Vaidyanathan, V., 308Vainio, H., 264Valdés-González, R.A., 140, 141Valensi, F., 172Valero, V., 173, 175Valle, J.W., 13Vallee, R.B., 201Vamvakaki, M., 5, 335, 339van Aalten, D.M.F., 283Van Blitterswijk, C.A., 226van Dam, H.J.J., 274, 307van de Wetering, P., 14, 18–20van den Berg, A., 227van den Broek, M., 202van der Aa, M.A., 202van der Horst, P.M., 55van der Lubben, I.M., 120van der Vegt, N.F.A., 283van Deurs, B., 8van Dijk, J.A.P.P., 55van Dijk, M., 135van Es, T., 4, 11, 12van Geemen, D., 233, 244, 245van Gunsteren, W.F., 282, 283van Heerikhuize, J.J., 189Van Heyningen, W.E., 207Van Hoof, F., 200van Luyn, M.J., 322van Mello, N.M., 172van Nostrum, C.F., 7, 8, 12, 135Van Rietschoten, J., 206van Schilfgaarde, R., 140–143van Steenbergen, M.J., 14, 18Van Tomme, S.R., 227

Van Vlierberghe, S., 227, 228, 236van Wachem, P.B., 322van Weeren, P.R., 246, 247van Zanten, J., 140, 143Vander Heiden, M.G., 259Vanderkerken, S., 11Vanderleyden, E., 228Vandivort, K.L., 308Vanhoof, F., 3Vanrooijen, N., 5Varaprasad, K., 338Varathalingam, A., 174Varela, J.A., 75, 77, 78Varga, F., 233Vargeese, C., 169Varghese, D., 245Varma, D., 201Varma, M.V.S., 58Varma, R., 318Varum, F.J., 115Vårum, K.M., 196, 197, 202Vasani, R., 264Vasapollo, G., 274Vasey, P.A., 3Vattulainen, I., 284Vauthier, C., 118, 324Vaz, D.C., 228Vazquez, A., 256Veiga, F., 111, 112, 115, 116, 121Veitch, H.S., 119Veldhoen, S., 157, 170Velegol, D., 77Venkaiah, B., 16Venkataraman, S., 321, 339Venkatesh, S., 195Venkatraman, S.S., 234, 301Ventre, M., 146Verfaillie, C.M., 247Verhaagen, J., 189Verhoef, J.C., 120, 285, 286Verkman, A.S., 13, 158, 201Verma, A., 319–321Verma, I.M., 157, 158, 188–190Verma, S., 200Vermonden, T., 227Vernachio, J.H., 161Veronese, F., 11Veronese, F.M., 11, 343Vert, M., 333Vervaet, C., 302Veryazov, V., 274, 307Vespignani, I., 120Vicari, S.M., 262Vidal, D., 94

Author Index 403

Vierling, P., 190Vigne, E., 189Viktorov, N.A., 263Vilatoba, M., 143Vilhardt, F., 8Viljoen, A., 128Villa, A., 282, 283Villaret, D., 175Viñas-Castells, R., 322Vincent, B., 58, 59Vincent, M.J., 21Vincenti, F., 130Vinogradov, S., 12, 13Viola, J.R., 195Visigalli, I., 189Vivero-Escoto, J.L., 197Vives, E., 171Voet, D., 258Voet, J.G., 258Voet, V., 333Vogelson, C.T., 321Voges, J., 173, 176Vogler, B., 264Voigt, A., 256Voigt, K., 194Voigt, K.H., 195Volkov, V., 308von Bohlen, A., 259von Giesen, H.J., 186von Harpe, A., 194Von Kalle, C., 172Vornlocher, H.P., 169Vortherms, A., 119Voth, G.a., 284Votruba, A.R., 274Voutetakis, A., 172Vozzi, F., 245Vozzi, G., 245Vtyurin, B., 259Vuilleumier, C., 9Vuorimaa, E., 293

WWacker, W.E., 264Waddell, B.E., 173, 174Wadhwa, M.S., 192Wagner, E.F., 10, 13, 14, 16–18, 163, 164, 170,

194, 195, 199–201, 204Wagner, K.G., 70Wahlgren, M., 301Wahlund, P.O., 70Wakabayashi, T., 173, 174Wakabayashi, Y., 189

Wakefield, D.H., 9Walczyk, D., 75Walker, A., 317, 319Walker, G.F., 195Walker, L.M., 328Walker, S.M., 292Walser, P.J., 318Walsh, A.P., 187Walsh, K., 16Walter, E., 10, 20, 200Wan, L., 18Wang, A.Z., 2Wang, B., 69, 190, 197, 273Wang, C.H., 4, 296, 299–301, 305Wang, C.L., 204, 208Wang, C.Y., 193Wang, D.A., 195Wang, D.Y., 234Wang, F., 77Wang, G., 169Wang, H., 208, 332Wang, J.J., 164, 169, 172, 195,

283, 317, 318, 321, 322,324, 344

Wang, J.S., 326Wang, L., 262, 339Wang, L.J., 189Wang, P.G., 164Wang, Q., 282Wang, Q.Y., 170Wang, R., 197Wang, S., 193, 204, 207, 233Wang, S.L., 322Wang, T., 164Wang, W., 21, 141, 146, 192, 193, 333Wang, X., 164, 204, 207, 246, 256Wang, X.S., 12, 13Wang, Y., 61, 196, 204, 205Wang, Y.H., 259, 262Wang, Y.L., 319, 320Wang, Y.S., 11, 168Wang, Y.-Y., 116, 118Wang, Z., 21Wara, D., 172Warburg, O.H., 256, 259, 264Ward, C.M., 193Ward, S.G., 262Waring, L., 45, 46Warnock, G.L., 130, 141Warren, G., 9, 16Washbourne, P., 198Wasil, M., 6Watanabe, A., 246Watkins, S.C., 162, 198

404 Author Index

Watts, C., 318Wawrowsky, K.A., 204Way, H., 161Weaver, J.V.M., 338Webb, A.K., 173, 174Webber, M.J., 58Weber, K., 168Weber, L.M., 136, 143Weber, P.C., 189Wechuck, J., 189Wedeking, T., 161Weener, J.W., 193Wei, M.C., 18Wei, T., 21Wei, T.T., 75Wei, X., 324Wei, Y.Q., 168Weiden, P.L., 173, 175Weigel, G., 233Weil, T., 322Weinberg, K., 172Weiner, B.B., 89, 90, 103Weinhold, M., 120Weir, G.C., 140Weiss, C., 256Weiss, J., 338, 339Weissenboeck, A., 119Weitzman, M.D., 190Weksler, B.B., 203Welham, M.J., 113Weljie, A.M., 257Welsh, M.J., 201Welsher, K., 197, 343Wen, J., 195, 196Wen, L., 204, 205Wen, S., 195Wengel, J., 187Wennerström, H., 42, 44, 46Wente, S.R., 202Wenz, E., 332Wenz, M., 14, 158, 190West, M., 261West, P., 94West, S., 11West, T., 135Whateley, T.L., 61Wheat, A.J., 169Wheeler, C.J., 160, 161, 190Wheeler, R.A., 273Whitaker, J., 261Whitaker, R.M., 208White, D.J., 140, 141Whitehead, K., 274Whitehead, K.A., 157

Whitesides, G.M., 329Whitman, E., 173, 175Whittaker, G.R., 202Wicker, R.B., 233, 236, 239Widmer, F., 136Wienhard, K., 173, 176Wierzbicki, A.S., 128Wiethoff, C.M., 157, 198Wigent, R., 286Wilbur, F.S., 20Wilderspin, A.F., 193Wilke, M., 202Wilkinson, J.H., 264Willeke, F., 256Willeke, K., 88Willey, J.S., 173, 175Williams, F.E., 115Williams, J.C., 201Williams, P., 130Williams, P.A., 57Williams, P.M., 5Williams, R.E., 256Williams, S., 19, 21, 22Williams, T., 170Willmarth, N.E., 189Willmitzer, L., 70Wils, P., 164, 199, 202Wilschut, J., 16Wilschut, K.J., 202Wilson, G., 6Wilson, J.M., 172, 189Wilson, J.T., 131, 132, 135, 136, 140–145Wilson, M.R., 20Wilson, P., 3Wilson, W.C. Jr., 243, 245Winans, A.M., 323Wind, F., 256, 259Windecker, S., 2Winter, D., 140Winter, N.D., 294Wintergerst, U., 172Wiradharma, N., 339Wirth, M., 119Wissler, M., 172Witten, T.A., 58Wittmer, S., 103Wivel, N.A., 172Wiwattanapatapee, R., 193Wixon, J., 172Wohlfart, S., 203Woitiski, C.B., 116, 121Wolburg, H., 203Wolf, J.K., 173, 175Wolf, R.M., 283

Author Index 405

Wolfe, D., 189Wolfert, M.A., 193Wolff, J.A., 9, 190, 202Wolman, S.L., 261Wolpert, K.V., 189Won, Y.Y., 15, 18, 202Wong, F.M., 161Wong, J., 169Wong, K., 2, 196Wong, L.F., 16Wong, S.C., 9Wong Shi Kam, N., 343Wong, T.W., 114Woo, S.L., 199Woodhouse, K.A., 321Woodman, B.F., 346Woodward, M., 11, 19, 20Wortmann, F.-J., 59Wu, B., 243Wu, C.C., 141Wu, C.H., 192, 200Wu, C.W., 197Wu, D., 203Wu, G.Y., 192, 200Wu, H., 22, 187, 204, 205, 322Wu, H.Y., 77Wu, J., 6, 13, 261Wu, J.H., 264Wu, K.K., 10, 18, 194Wu, P.K., 245–249Wu, R., 246Wu, S.H., 76Wu, S.P., 162, 198Wu, S.S., 207Wu, W., 332Wu, Y.Y., 21, 119Wulffraat, N., 172Wurdinger, T., 186Wustmann, K., 2Wyllie, S., 141, 143Wyss, D.F., 11

XXi, Q., 204, 208Xia, C.F., 203Xia, H., 208Xia, J.H., 326Xia, T., 77Xia, W., 173, 175Xiang, J., 197Xiang, L., 164Xiang, T.X., 281, 284Xiao, K., 321

Xiao, R.Z., 322Xiao, W., 321Xiao, X., 189Xiao, Z.P., 200Xie, J., 165Xie, T., 322Xie, Y., 247Xing, G.M., 75Xing, J., 21Xing, X., 175Xinhuai, Z., 281Xiong, C.D., 21Xiong, D.A., 332, 339Xiong, X.B., 324Xiong, Z., 246Xu, B., 22Xu, D.M., 200Xu, F., 246Xu, J., 204, 208Xu, M.C., 69Xu, Q., 21Xu, R.H., 259, 261Xu, S., 168, 188Xu, T., 245Xu, X., 334Xu, Y., 190, 197Xu, Z., 245

YYadav, R., 322Yadav, S.C., 322, 324Yadav, S.K., 322, 324Yahia, L., 196Yalcin, A., 168Yamada, Y., 13Yamaguchi, K., 13Yamahira, T., 12Yamamoto, S.I., 167, 264, 322, 336Yamano, S., 172Yamano, T., 193Yamashita, F., 171, 172Yamato, M., 13Yamauchi, J., 165Yan, J., 338Yan, L., 328Yan, Y., 246Yancey, R.J. Jr., 22Yandrapu, S.K., 119Yang, C., 208Yang, C.W., 4, 6, 7Yang, D.J., 323Yang, F.Y., 75Yang, H.S., 168, 338

406 Author Index

Yang, H.W., 119Yang, K.C., 141Yang, L.L., 262, 281, 328Yang, M., 118Yang, N.S., 2Yang, R., 208Yang, S.Y., 228, 330, 332, 333, 338, 342Yang, T.F., 4Yang, V.C., 204, 205Yang, W., 275, 280Yang, X.L., 75, 227Yang, Y.H., 197Yang, Y.Y., 321Yang, Z.Y., 190Yanga, Y.Y., 339Yao, L., 208Yao, Q.X., 136, 140, 141Yao, S.D., 200Yao, Y.D., 77, 324Yao, Z., 136, 140, 141Yaouanc, J.J., 158–160Yardley, J.E., 129Yasui, H., 13Yaszemski, M.J., 233Yatvin, M.B., 15Yaworski, E., 169Ye, C., 75Ye, L., 204–206Yefimov, S., 284Yeh, M.K., 190Yemisci, M., 204Yeom, Y.I., 200Yessine, M.A., 5, 12, 13, 18–20Yew, N.S., 160, 174Yin, C., 321Yin, H., 261Yin, L., 321Ying, W.B., 204, 207Yip, S., 273Yla-Herttuala, S., 194, 198Yliperttula, M., 293Yokota, T., 169Yokoyama, M., 12, 13Yoo, G.H., 175Yoo, J.W., 316, 320Yoo, M.K., 200Yoo, S.-S., 246Yoon, D.Y., 200Yoon, J.K., 194York, A.W., 340Yoshida, J., 173, 174Yoshida, K., 229Yoshikawa, T., 13Yoshioka, T., 261, 263

Yoshizawa, N., 262You, H., 20You, Y.Z., 333Youan, B.B., 71Young, A., 207Young, C., 143Young, D., 245, 246, 248, 249Youngster, S., 11Yu, B., 164Yu, C.C., 343Yu, D.F., 323Yu, E.Z., 169Yu, F., 227Yu, J., 256Yu, P.H., 264Yu, S., 333Yu, S.C., 343Yu, W.Y., 343Yu, Z., 166Yuan, F., 6Yuan, H., 75Yuan. J., 342Yuan, W., 342Yudkoff, M., 172Yue, Z., 19, 21, 22Yuen, W.W., 144, 146Yuk, S.H., 336Yukawa, M., 263Yuksel, N., 324Yun, T.K., 264Yunes, J.A., 261, 263Yung, B.C., 164Yushko, L.A., 261, 263Yvon, E., 172

ZZaat, S.A., 322Zabner, J., 14, 189, 201Zacharieva, E.I., 11Zaghloul, E.M., 195Zahr, A.S., 320Zaichick, V., 259Zana, R., 60Zander, D.S., 262, 263Zanta, M.A., 14, 18, 166, 194, 202Zatloukal, K., 13, 16, 17Zattoni, A., 105Zauner, W., 13, 14, 16–18, 194Zecheru, T., 324Zedalis, W., 169Zeitlin, P., 118Zekorn, T., 138

Author Index 407

Zelikin, A., 71Zelivyanskaya, M., 144Zelphati, O., 161Zeng, J., 204, 207, 332Zeng, X., 200Zeng, Z.W., 322Zera, R.T., 193Zerbini, L.F., 259Zerilli, M., 256Zetterlund, P.B., 326Zezin, A.B., 63Zha, Y., 204, 205Zhan, X.R., 322Zhang, B., 332Zhang, C., 171Zhang, D.Q., 262Zhang, G., 202Zhang, G.D., 12, 15Zhang, H., 187Zhang, J., 197, 256Zhang, L., 2, 12, 13, 322, 343Zhang, M., 189, 264Zhang, M.Q., 323Zhang, N., 164, 343Zhang, P.Z., 324Zhang, Q., 204, 205Zhang, R., 246Zhang, S., 21, 22, 173, 175Zhang, S.H., 190, 197, 204, 207Zhang, W., 21, 164Zhang, X.J., 21, 75, 338Zhang, X.Z., 196, 200, 208Zhang, Y., 203, 204, 308, 322, 332, 339Zhang, Y.F., 163, 168, 170Zhang, Y.G., 69, 75Zhang, Z., 200, 322Zhao, B., 339Zhao, C.H., 262Zhao, D., 60, 322Zhao, F., 75Zhao, X., 322Zhao, Y., 21, 264Zhao, Y.L., 75Zhen, Y., 262Zheng, C., 172Zheng, Q., 245Zheng, S., 342Zheng, T., 136, 140, 141Zheng, W., 162, 264

Zhong, C.J., 95Zhong, W., 199Zhou, D., 56, 141Zhou, G.L., 322Zhou, J.R., 208, 259Zhou, W.Z., 200Zhou, X.K., 168, 191Zhou, Y.C., 256, 262Zhu, H., 208Zhu, J., 12, 13Zhu, J.H., 200, 204, 205Zhu, J.L., 200Zhu, K., 56Zhu, L.A., 262Zhu, W., 69Zhu, Y.A., 197Zhu, Y.G., 262Zhu, Z., 227, 338Zhuang, Y., 12, 13Zhulina, E.B., 55Zhuo, R.X., 200Zia, J.K., 20Zidemane, A.A., 263Ziegler, D., 128Ziegler, M.J., 327Zimmermann, A., 262Zimmermann, T.S., 169Zimmermann, U., 138Zinman, B., 113Zinnen, S., 169Zinselmeyer, B.H., 193Zisenis, M., 332Zissi, S., 233Zoete, V., 283Zöphel, L., 322Zorlutuna, P., 234, 235, 237, 238Zou, S.M., 196Zou, Y., 18Zrínyi, M., 338Zu, Y., 322Zuber, G., 195Zuccato, C., 186Zucchi, O.L.A.D., 259Zuhorn, I.S., 199Zuidam, N.J., 161Zumbusch, G., 282Zunino, F., 281Zuo, L., 283Zur Hausen, A., 256

Subject Index

AAFM. See Atomic force microscopy (AFM)Amphiphilic molecules

drug concentration, 36drug delivery and cells (see Drug delivery

systems)drug delivery vehicle, 36–37pharmaceutical formulations, 37physicochemical features, 37polymer-polymer and polymer-surfactant

mixtures (see Polymer-polymer andpolymer-surfactant mixtures)

polymers (see Polymers)properties, soft systems, 36states of matter, 36surfactants (see Surfactants)vehicle degradation and drug release, 37

Amphiphilic polymersgrafted/end modifications, 57HMPs, 57phase diagram, EO-PO-EO copolymer, 58poloxamers, 58

Anionic polymersbiodegradable polymer chains

function of pH, 21hydrolytically/enzymatically cleavablelinkages, 21metabolite-derived synthetic, 21PAA and PGA, 21PP-75, 22

description, 19non-biodegradable polymer chains

EG.7-OVA mouse tumor protectionmodel, 21PBAA, 20

PEAA, 19–20ternary complexes, 20

Antisense oligonucleotides (AONs)CH and complexation conditions, 197and siRNA, 196, 198

AONs. See Antisense oligonucleotides(AONs)

Atomic force microscopy (AFM)description, 93industries, pharmaceuticals to

semiconductors, 94modes of operation, 94–95optical beam deflection system, 94probe geometry and sample texture, 94SEM and TEM, 95

Atom transfer radical polymerization (ATRP)copolymeric architectures, 327functional polymeric materials, 327mechanism scheme, 325

ATRP. See Atom transfer radicalpolymerization (ATRP)

BBioartificial pancreas

clinical applicationinflammatory reaction, 142–143particle size, 140–141transplantation site, 141

diabetes“-cell changes and reduction, insulinaction, 128, 129classification, 128–129conventional treatments, 129–130epidemiology, 128

J. Coelho (ed.), Drug Delivery Systems: Advanced Technologies PotentiallyApplicable in Personalised Treatment, Advances in Predictive, Preventiveand Personalised Medicine 4, DOI 10.1007/978-94-007-6010-3,© Springer ScienceCBusiness Media Dordrecht 2013

409

410 Subject Index

Bioartificial pancreas (cont.)innovative treatments, regenerativemedicine, 131–132insulin-producing tissue transplantation,130–131metabolic disease, 128

optimal environment, implantcontribution, cells, 146–147delivery systems, 144, 146polymers functionalization, bioactivesubstances, 144–146

treatment (see Diabetes treatment)Biofabrication, hydrogel constructs

biomanufacturingcomputer solid model, 230imaging methods, 230inkjet printing processes, 243–248layer-by-layer fashion, 230stereolithography, 230–242

hydrogel, 227–229tissue engineering, 225–227

Biological laser printing (BioLP), 248BioLP. See Biological laser printing (BioLP)2,3-Bis[oleyl]oxipropyltrimethylammonium-

chloride (DOTMA), 159, 160Blood-brain barrier (BBB). See “Closed” BBB

gateway

CCAC. See Critical aggregation concentration

(CAC)Calcium phosphate cement (CPC)

alginate composite fibrous network,production, 243–244

micro-CT images, 244production, alginate composite fibrous

network, 243–244Calf timus DNA (ctDNA) with FA-covalently

coupled cationic liposomes(ctDNA-FA-CLs), 164

Cancer cellsaerobic glycolysis, 256glycolysis, 258

Cancer therapyangiogenesis and tumor growth, 257biochemical changes, 257description, 257LDH, 257saving and prolonging lives, 257

Cationic lipidsdrawbacks, in vivo delivery,

191–192formation, liposomes, 190, 191

hydrophobic group, 190physical factors, 191

Cationic liposomes-based systemsbiological activity

development, lipoplex formulations,162endosomolytic agents, 165nuclear translocation, 165–166targeting ligands (see Targeting ligands)

clinical trialsaberrant transcription and expression,LMO2, 172allovectin-7 formulation, 174–175antitumoral strategies, 174CFTR protein, 173–174gene therapy, 172HER-2/neu encoding, 175non-viral gene transfer, CF patients, 174representative gene therapy, 172, 173tgDCC-E1A, 175TIL, 172

concept, gene therapy, 166description, 156and DNA delivery (see DNA delivery and

cationic liposomes)functional entities, 158nucleic acid delivery, 157–158and oligonucleotide delivery (see

Oligonucleotides (ONs) delivery)physicochemical parameters

bilayer fluidity controlling, 161chemical structures, helper lipids, 159complexes composition, 162composition/structure, 160DOPE and Chol, 160–161DOTMA and DOTAP, 160electrostatic repulsive forces, 161lipid/DNA charge ratio, 161, 162lipids, 159lipoplexes, positive zeta potential, 161phosphatidylcholine derivatives, 160therapeutic efficiency, 158toxic lipoplexes, 160

physiological/cellular barriers, transfection,157

and RNA interference (see RNAinterference (RNAi))

Cationic polymerschitosan (CH), 195–197cytotoxicity, 19dendrimers, 193–194description, 192electrostatic and hydrophobic interactions,

18

Subject Index 411

PEI (see Poly(ethylene imine) (PEI))pH-responsive, 18PLL (see Poly(L-lysine) (PLL))PLL, PEI, PDMAEMA and PAMAM, 18proton-sponge mechanism, 18, 19

CDDS. See Controlled drug delivery systems(CDDS)

Cell entrance and intracellular traffickingATP-mediated proton accumulation, 200cationic nanoparticles, 200in vivo studies, 199lipid-based complexes, cytoplasm, 201macropinocytosis, 199–200membrane destabilizing peptides, 200–201phagocytosis, 199PLL-DNA complexes, 198poly(lactic acid-co-glycolic acid), 200transfection process, 201

CFD. See Computational fluid dynamics(CFD)

CFTR. See Cystic fibrosis transmembraneconductance regulator (CFTR)

Clathrin-mediated endocytosis (CME)endocytic mechanism, 318internalization, plasma membrane, 318pinocytosis, 317

“Closed” BBB gatewaydendrigraft PLL (DGL), 205–206description, 203drugs availability, 206mAbs vs. Tf and insulin, 203PAMAM-based gene delivery vector,

205Pep-TGN, 205PMLA, 204RMT, 203RVG29, 205synthetic peptides, 205Tf and lactoferrin (Lf) proteins, 204

CLRP. See Controlled/living radicalpolymerization (CLRP)

CMC. See Critical micellar concentration(CMC)

CME. See Clathrin-mediated endocytosis(CME)

Computational fluid dynamics (CFD)aerosol delivery, 305–306aerosol transport and deposition, 306cerebrospinal fluid pulsations,

306–307computational flow modeling, 296computer-generated analyses, 304description, 294development stages, 304

diffusion-advection equation, 298drug concentration profile, 297erosion kinetics, 302flow models (see Computation flow

models)mass transport limitations, 301micro-and nano-scale design tool, 303Navier-Stokes equations, 297non-biodegradable polymer matrix, 300openFOAM and ANSYS, 305pharmaceutical and drug developer, 303physical/chemical characteristics, 299polymer matrix categorization, 299protocols and system configuration, 300requirements, tools, 296research and design activities, 304visualization techniques, 296

Computation flow modelsdispersed-phase particles, 303Fick’s second law, 302laminar flow, 301LES, 302RANS-based turbulence models, 302viscous flow models and categorization,

301–302Controlled drug delivery systems (CDDS),

144Controlled/living radical polymerization

(CLRP)ATRP, 325, 326chemical functionality, 327nanometric scale, 328nanotechnology (see Drug delivery systems

(DDS))polymeric architectures, 326–327post-polymerization modification, 327, 328self-assembly, block copolymers, 329–346

Controlled releasedoxorubicin, 11and drug delivery, polymers, 3pharmacokinetic issues, 14physical and chemical stimuli, 3therapeutic agents, 4

CPC. See Calcium phosphate cement (CPC)CPP. See Critical packing parameter (CPP)Critical aggregation concentration (CAC)

anionic surfactants, 63binding isotherm when CAC(2), 65cooperative binding, 63defined, 63micelles sizes, 63polyions, 64surface tension, presence and absence of

homopolymer, 64

412 Subject Index

Critical micellar concentration (CMC)CAC, 63micellization, 40solubilization, hydrophobic compounds,

48surface tension measurements, 40

Critical packing parameter (CPP)addition, salt to ionic surfactants, 43amphiphile geometry, 42cylindrical micelles, 43defined, mean and Gaussian curvature,

44ethyleneoxide head groups, 44–45free energy minimization, 42membrane topologies modeling, 44and preferred surfactant aggregate

structures, 43temperature dependence, 45

ctDNA-FA-CLs. See Calf timus DNA (ctDNA)with FA-covalently coupled cationicliposomes (ctDNA-FA-CLs)

Cystic fibrosis transmembrane conductanceregulator (CFTR)

CpG sequences, 174description, 173

DDCS. See Differential centrifugal

sedimentation (DCS)Density functional theory (DFT)

applications, 280electronic structure methods, 275HF method, 280

DFT. See Density functional theory (DFT)Diabetes treatment

auto-antibodies, 132biomaterials factors, bioartificial organs,

134membrane materials, cell encapsulation

biomaterials factors, bioartificial organs,134chemical structures, 136, 137non-polymeric materials, 135polymeric materials, 135–136

particles fabrication, coatingchemical reaction, 139emulsion coating technique, 136hydrophobic interaction, 140layer-by-layer method, 138–139size comparison, 136, 138

types, 133–134Differential centrifugal sedimentation (DCS)

accuracy, calibration standards, 103

advantages, 103gravitational, 101monochromatic light/X-rays, 103particle size distribution, 101typical configuration, disc, 102

Digital micromirror devices (DMDs), 2331,2-Dioleoyl-3-trimethylammonium-propane

(DOTAP)peptide/ON complexes, 171stable linker groups, 160Tf-lipoplexes, 163–164

Dipeptidyl peptidase-IV (DPP-IV) inhibitors,110, 111

DLS. See Dynamic light scattering (DLS)DMDs. See Digital micromirror devices

(DMDs)DNA

cationic lipids and polymers, 199DNA-PLL interaction and the

thermodynamic stability, 192endosomal escape, 201immunoliposomes, 203lysosomal degradation, 194molecular weight and degree of acetylation

(DA), 196nuclear envelope disruption, 202PEI and chitosan, 208regulation, gene expression, 187and RNA viruses, 188TFO, 188

DNA-cationic polymers, 70–71DNA delivery and cationic liposomes

EBV/lipoplex, 167HSV-tk/CD genes, 168HVJ cationic liposomes, 167metastatic tumor outgrowth, 167mucosal treatment, lipoplexes, 168recombination, fragments, 167tumor necrotic and hemorrhagic areas,

167–168UCL, 168

DNA-surfactant complexes, 69–70DPP-IV. See Dipeptidyl peptidase-IV (DPP-IV)

inhibitorsDrug delivery systems (DDS)

cell internalization process, 317–318and cells

carrier/system, 71–72development, bio-nanotechnologies,71nanoparticle choice, 72–74properties, nanoparticles (seeNanoparticles)protein corona (see Protein corona)

Subject Index 413

drug encapsulation and releaseamphiphilic block copolymers, 340amphiphilic copolymer, 340, 341drug and gene delivery, 340hydrophilic dendritic block, 343polymer vesicles, 342

functionalization, polymercellular targeting, 343click chemistry, 343hydrophobic anticancer drugs, 344pH-responsive liposome, 345

in silico research (see In silico research)mechanical properties, 320nanocarrier systems, 316physico-chemical properties, 316polymeric-based conjugates

bioconjugate synthesis methods,346macromolecular engineering, 345

polymeric segmentsCLRP methods, 325–329natural polymers, 322–323synthetic polymers, 323–325

polymer-polymer and polymer-surfactantmixtures, 68––71

polymersmulti-responsive systems, 59polyacrylate derivatives, 59stimuli, drug release activation, 59

properties, design, 316shape, 319–320size, 319surface properties, 320–321and surfactant structures

liquid crystalline phases, 49–50micelles, 48–49microemulsions, 50–51pharmaceutical formulations, 48vesicles, 50

Dynamic light scattering (DLS)areas of research, 95autocorrelation functions, particle

populations, 96, 97description, 95drawbacks, 99fundamental size distribution, 98hydrodynamic diameter, 98intensity as function of time, 96, 97monodisperse sample, 96–97number, volume and intensity distributions,

98, 99Stokes-Einstein Equation, 97–98typical experimental set up, 96

EEDX. See Energy dispersive X-ray

spectroscopy (EDX)Electron microscopy (EM)

composition and crystallography, 91EDX detector, 93electron/sample interaction results, signal

types, 91, 92ESEM, 93magnification, 91OM vs. TEM and SEM, 91, 92particle characterization, 91TEM and SEM, 93

EM. See Electron microscopy (EM)Endocytosis

caveolin-mediated, 8cell entry, non-viral vectors, 8cell internalisation, 8clathrin-mediated, 8non-viral delivery agents, 7phagocytosis, 8

Endosomal escape, 9Endosomolytic agents, 165Energy dispersive X-ray spectroscopy (EDX),

93Enhanced permeation and retention (EPR)

effectpassive tumour targeting, 6polymeric micelles, 13tumour angiogenesis and vasculature,

5–6Environmental SEM (ESEM), 93EPR. See Enhanced permeation and retention

(EPR) effectESEM. See Environmental SEM (ESEM)Extracellular barriers

renal clearance, 5serum stability

description, 4RES/MPS, 5

tumour targeting and accumulationEPR effect principle, 5–6ligand-attached polymeric deliverysystems, 7polymeric delivery agents, 5receptor-mediated delivery, 6

GGastrointestinal (GI) epithelium

chemical environment, 116enzymes and pH gradients, 115oral insulin delivery systems, 111

414 Subject Index

Ge-delivery, 262–263Gene therapy

cationic liposomes, 167, 172cell-surface receptors and ligands, 163clinical trials, 173defined, 187delivery, exogenous nucleic acids, 188hematopoietic stem cells, 172non-viral vectors (see Non-viral vectors)nucleic acid delivery systems, 176oligonucleotide-mediated gene therapy, 188technologies, 187–188

Glycolysisglycolysis inhibitors, 259lactic acid, 259LDH and NADH, 258metabolism, 259, 260minerals and trace elements, 261monocarboxylic acids, 259, 260

HHartree-Fock (HF) theory

ab initio method, 277electron correlation methods, 278HF-RH approach, 278matrix algebraic approach, 278

Herpes simplex virus-tymidine kinase(HSV-tk/CD) genes, 167, 168, 175

HF theory. See Hartree-Fock (HF) theoryHigh performance computing, 307–308HMPs. See Hydrophobically modified

polymers (HMPs)HPMA. See N-(2-

hydroxypropyl)methacrylamide(HPMA)

hPSC. See Human pluripotent stem cells(hPSC)

Human pluripotent stem cells (hPSC), 131Hydrogels

covalent/non-covalent interactions, 227crosslinked hydrophilic polymers, 227crosslinking methods, 227, 228drug delivery applications, 228environmental stimuli, 229

Hydrophobically modified polymers (HMPs)amphiphilic properties, polymers, 57defined, 57polymer micelles, 63

IIFG. See Impaired fasting glucose (IFG)IGT. See Impaired glucose tolerance (IGT)Impaired fasting glucose (IFG), 110

Impaired glucose tolerance (IGT), 110Inflammatory processes

device, 142encapsulated cells, 143islet transplantation, 142surgery, 143

Inkjet printing processesBioLP system, 248bio-paper, 245collagen, 243CPC, 243–244droplet formation process, 243generic representation, multi-head printer

system, 246, 247MAPLE DW system, 248multinozzle biopolymer deposition system,

246, 247organ printing process, 244, 245thermal and piezoelectric printers, 245, 246

In silico researchCFD (see Computational fluid dynamics)computational chemistry, 272computer simulation, 272DDS, 273description, 272high-performance computing, 307–308modeling and simulation (see Modeling)pharmaceutical industry, 273project/development, 272, 273

Insulin nanoparticles (NPs)areas of flow and transport, 113–114barriers, 114–115diabetes mellitus, 110gastrointestinal (GI) tract, 116gene products encoding, 110hydrophobic and hydrophilic polymers, 116IGT/IFG, 110mean 24-h physiologic serum and plasma

glucose levels, 112nanocarriers, 111nanoparticulate on insulin uptake, 120–121and nanotechnology (see Nanotechnology)paracellular (see Paracellular pathway)parenteral administration, 112peripheral hyperinsulinemia, 113pharmacodynamic properties, 113reproducibility studies, time-action profiles,

113structure and particle translocation,

intestinal epithelium, 117therapeutic proteins and antibodies,

110–111transcellular (see Transcellular insulin

pathway)

Subject Index 415

treatment, diabetes, 111types, formulations available in market, 113

Intracellular barriersendocytosis, 7–8endosomal escape, 9nuclear localization, 10trafficking, polymeric delivery agents, 7

Intracellular deliverybiopharmaceuticals, 22–23cationic polymers, 18macrodrugs, 15membrane-disruptive viral and synthetic

peptides, 18non-viral vectors, endosomal pathways, 9poly(amino acids), 21PP-75, 22

Islets encapsulationfree insulin diffusion, 142natural and synthetic polymer, 135thermoplastics, 135

LLactate dehydrogenase (LDH)

inhibitor, 263NADH oxidation, 258

Large eddy simulations (LES), 301–302Laser-induced forward transfer (LIFT), 246LCD. See Liquid crystal display (LCD)LDH. See Lactate dehydrogenase (LDH)LES. See Large eddy simulations (LES)LIFT. See Laser-induced forward transfer

(LIFT)Light scattering

dynamic (see Dynamic light scattering(DLS))

laser, 99Mie theory, 103

LIM domain only 2 (LMO2), 172Lipoplexes

biological activity and cytotoxicity, 160cationic lipids, 159gene delivery capacity, 161intratumoral administration, 167intratumoral injections, tgDCC-E1A, 175mucosal treatment, 168positive zeta potential, 161transdermal penetration and DNA

expression, 168transfection efficiency, 165

Liquid crystal display (LCD), 233Liquid crystalline phases

cubic structures, 49–50description, 49discrete/reverse micelles, 49

drawbacks, 50LMO2. See LIM domain only 2 (LMO2)

MmAbs. See Monoclonal antibodies (mAbs)Matrix assisted pulsed laser direct write

(MAPLE DW), 248MCP-1. See Monocyte chemotactic protein-1

(MCP-1)MD. See Molecular dynamics (MD)Micelles

control, release rate, 49esters and anhydrides, 49hydrolysis/enzymatic degradation,

48–49hydrophobic solutes, 48

Microemulsionsdescription, 50imporovement, drug efficacy, 51reversible process, 51

Microparticlesdrug delivery agents, 8efficiency, oxygen supply, 140fluorescently-labeled polystyrene, 239,

241material jetting process, 244requirements, in vivo application, 136size comparison, 138

MicroscopyAFM (see Atomic force microscopy

(AFM))EM, 91–93

MLVs. See Multilamellar vesicles (MLVs)Modeling

application, 273–275MD (see Molecular dynamics)quantum mechanics (see Quantum

mechanics)and simulation (see Simulation)

Molecular dynamics (MD)description, 281drug design, 281drug permeability, 281force field, 283–284kinetic and potential energy, 282–283temperatures and pressures, 282

Monoclonal antibodies (mAbs)naked siRNA delivery, 203polymer-based vectors, nucleic acid

delivery, 204Monocyte chemotactic protein-1 (MCP-1),

143Mononuclear phagocytic system (MPS), 5

416 Subject Index

MPS. See Mononuclear phagocytic system(MPS)

Multi-component polyplexescationic polymers, 14definition, 13structure and properties, polymeric carriers,

14Multilamellar vesicles (MLVs)

description, 50equilibrium planar lamellar structure, 50

NNanoaggregates, 35Nanocarriers, DDS

mechanical properties, 320shape, 319–320size, 319surface properties, 320–321

Nanomedicinenanovehicles and the bio-systems, 72polymeric micelles, 12

Nanoparticles. See also Insulin nanoparticles(NPs)

analysis and individual interpretation, 78cellular responses, 77cellular uptake efficiency, 76non-specific hydrophobic effects, 77–78“protein corona”, 76toxicity and adverse effects, 77uptake pathways, 76

Nanoparticle tracking analysis (NTA)Brownian motion and Stokes-Einstein

equation, 99vs. DLS, 100video tracking, 99working principle, 100

Nanotechnologyinsulin carrier

enzymatic degradation and insulinpermeability, 115mucoadhesive delivery systems, 115oral delivery, 115

nanoparticles, 116Natural polymers

polysaccharides, 322–323proteins, 322–323

Nerve guidance conduit (NGC), 236, 239Neurodegenerative diseases

nervous system dysfunction, 186neurotrophic factors, 186

Neuropathiesconsequence, systemic illness, 186therapeutic approaches, 208

NGC. See Nerve guidance conduit (NGC)

N-(2-hydroxypropyl)methacrylamide (HPMA)copolymer-anticancer drug conjugates, 3non-biodegradable, 11

Nitroxide mediated polymerization (NMP),345

NMP. See Nitroxide mediated polymerization(NMP)

Non-viral delivery agentsanionic polymers (see Anionic polymers)cationic polymers (see Cationic polymers)description, 10multi-component polyplexes, 13–14polymer-drug conjugates, 10–11polymeric micelles, 12–13polymer-modified liposomes, 14–15polymersomes, 15

Non-viral vectorsbiomaterial-based, 197cationic lipids, 190–192cationic polymers (see Cationic polymers)“closed” BBB gateway, 203–206description, 190neuronal cell, 206–208neuronal cell targeting ligands, 203, 204

NTA. See Nanoparticle tracking analysis(NTA)

Nuclear localizationdiffusional and metabolic barriers, 10NPC, 10siRNA, 10

Nucleic acid-based therapeutic strategiescationic liposomes, 158description, 166DNA delivery, 167–168oligonucleotide delivery, 170–172RNA interference, 168–170

Nucleic acid deliverybarriers

cell entrance and intracellulartrafficking, 198–201description, 198non-viral gene carrier, 198, 199nuclear uptake, 201–203vector stability, 198

gene therapy, 187–188nervous system, 186neurodegenerative diseases, 186neurotrophic factors, 186non-viral gene delivery vector (see

Non-viral vectors)peripheral neuropathies, 186therapeutic intervention, 187viral vectors (see Viral vectors)

Subject Index 417

OOligonucleotides (ONs) delivery

aberrant splicing, human diseases, 170cationic liposomes, 171D-(KLAKLAK)(2) and G3139, 171interleukin-13 (IL-13), 171Man-liposomes and NFkB activation,

171–172mechanisms, 1702’-O-methyl-RNA antisense molecules,

171translational arrest/mRNA degradation, 170

Oncaspar® (PEG-L-asparaginase), 4Open field operation and manipulation

(OpenFOAM), 305Oral bioavailability. See Insulin nanoparticles

(NPs)

PPAA. See Polyacrylic acid (PAA)Paracellular pathway

NPs, 119–120tight-junctions (TJs), 119

Phase diagramscomponents, 46constraints and free energy packing, 47lamellar phases, 46non-ionic surfactants, CnEm type, 45–46oil/surfactant/cosurfactant/water system, 46

Photon correlation spectroscopy (PCS), 95pH-responsive membrane-disruptive delivery

agentsdescription, 15–16non-viral

anionic polymers, 19–22cationic polymers, 18–19

viral and synthetic peptides (see Syntheticand viral peptides)

viral vectors, 16PLL. See Poly(L-lysine) (PLL)PLLA. See Poly(L-lactic acid) homopolymer

(PLLA)Pluronics®, 56PMLA. See Poly(malic acid) (PMLA)PNIPAM. See Poly(N-isopropylacrylamide)

(PNIPAM)Polarized continuum model (PCM), 286–287Poly(’-butylacrylic acid) (PBAA), 20Poly(’-ethylacrylic acid) (PEAA), 19–20Poly(ethylene imine) (PEI), 194–195Poly(glutamic acid) (PGA), 21Poly(L-lysine) (PLL), 192–193

Poly(malic acid) (PMLA), 204Poly(N-isopropylacrylamide) (PNIPAM), 12Polyacrylic acid (PAA), 21, 293–294Poly(amidoamine) (PAMAM) dendrimers, 14,

193–194Polyelectrolyte-surfactant nanoparticles, 68Poly(L-lactic acid) homopolymer (PLLA),

290–291Polymer gels, protein delivery, 69Polymer gel-surfactant mixtures, 68Polymeric micelles

core-forming segments, 12endosomal compartments, 13hydrophobic interaction and van der Waals

cohesion, 12nanomedicine platform, nucleic acids, 12NK105 and SP1049C, 13polycations and polyanions, 12shell-forming components, 12

Polymer-modified liposomesanticancer agents, 14description, 14limitations, 14PEG, 15

Polymer-polymer and polymer-surfactantmixtures

asymmetry, 62–63CAC and redissolution phenomena (see

Critical aggregation concentration(CAC))

combinations, neutral species, 664-component system, 65, 66cytotoxicity, 71DNA-cationic polymers, 70–71DNA-surfactant complexes, 69–70drug delivery systems, 68–71fundamental science to industrial

applications, 60gelling agents/rheology modifiers, 60Gibbs’ triangle, 65liquid crystalline phases, 66oppositely charged mixtures, 66–67phase behavior, 61–62polyelectrolyte-surfactant nanoparticles, 68polymer gels, protein delivery, 69polymer gel-surfactant mixtures, 68protein-surfactant mixtures, 69rheology, 67–68

Polymersamphiphilic (see Amphiphilic polymers)chemical and physical versatility, 51concentration regimes, 56description, 51

418 Subject Index

Polymers (cont.)drug delivery systems (see Drug delivery

systems)microgels, 58polyelectrolytes, 56–57properties

degree of polymerization (DP), 51examples, molecules, 52–54molecular weight, 52and monomer organization, 52

in solutionamphiphilic, 53characteristic ratio, C1, 55coil dimension, 55description, 53diblock, 55Flory-Huggins theory, 55Pluronics®, 56

tissue engineering scaffolding, 51Polymersomes, 15Potential energy surface (PES), 277Protein corona

cellular receptors, 75colloidal drug vehicles, 75defined, 72–73macrophages, 75nanovehicles and the bio-systems

interactions, 72particle bio-distribution within cell,

75protein binding, 75

QQELS. See Quasi-elastic light scattering

(QELS)QM. See Quantum mechanics (QM)Quantum mechanics (QM)

ab initio methods, 278Born-Openheimmer approximation,

276–277DFT methods, 275dynamic simulations, 281electronic structure calculations, 276Hartree-Fock framework, 278, 279HF method, 278HF-RH approach, 278Hohenberg-Kohn theorems, 280molecular characteristics, 276PES, 277Slater determinant, 277wavefunction, 280

Quasi-elastic light scattering (QELS), 95

RRabies virus glycoprotein (RVG29), 205RAFT. See Reversible addition fragmentation

transfer (RAFT)RANS. See Reynolds-averaged Navier-Stokes

equations (RANS)Reactive oxygen species (ROS), 142Receptor-mediated transcytosis (RMT), 203RES. See Reticuloendothelial system (RES)Responsive polymers. See Stimuli responsive

polymersReticuloendothelial system (RES), 5Reversible addition fragmentation transfer

(RAFT), 325Reynolds-averaged Navier-Stokes equations

(RANS), 301–302RMT. See Receptor-mediated transcytosis

(RMT)RNAi. See RNA interference (RNAi)RNA interference (RNAi)

anti-BCR-ABL siRNAs, imatinib drug, 169cationic cardiolipin analog, 169description, 168formulation, SNALPs, 169research tool and novel approach, human

diseases, 168–169siRNA-i-FECT complexes, 169–170transcription factor c-Jun, 170vaginal instillation, siRNAs, 170

ROS. See Reactive oxygen species (ROS)RVG29. See Rabies virus glycoprotein

(RVG29)

SScaffolds

dynamic masking system, 239PEG, 236SLA, 234tissue engineering, biomanufacturing

process, 230Scanning electron microscopy (SEM)

AFM, 95back scattering, 93EDX detector, 93electron microscope, 92

SdFFF. See Sedimentation field flowfractionation (SdFFF)

Sedimentation field flow fractionation (SdFFF)aggregation, colloidal samples, 104in biological field, 105FFF method, 103operation principle, 103–104

Subject Index 419

Self-assembly and phase behaviorexamples, surfactant structures, 41factors, 41hydrophobic effect, 40–41Krafft temperature, 39micelles and bilayers, 42micellization, 40non-polar molecules, 41physical properties, CMC, 40surface tension and self-association, 39Van der Waals, hydrogen bonding and

hydrophobic associations, 42Self-assembly, block copolymers

complexity vs. diversity, structures, 329,330

DDSdrug encapsulation and release,340–343polymer functionalization, 343–345polymeric-based conjugates, 345–346

equilibrium ordered states, 330, 331micellar structure, Israelachvili’s packing

parameter, 331molecular structure factors, 332phase separation, 329responsive polymeric systems

multi-responsive polymeric structures,338–339pH, 335–336reversible physical/chemical changes,334stimuli-responsive polymers, 338temperature, 336–338

role, polymeric segmentscore, 333–334crosslinking, 334responsive segments, 334steric stabilizer, 332–333

SEM. See Scanning electron microscopy(SEM)

SFRP. See Stable free radical polymerization(SFRP

SimulationBAEEHCC.Cl–, 285–287CG models, 293–294CH and NH bond lengths, 289chemical accuracy level, 285coarse grain approach, 293, 295description, 284H-bonding interactions, 287hierarchical models, 292isolated-molecule calculations, 289

ligand-protein complexes, 291MD calculations, 293, 294PAA, 293PCM, 286PEG, 293periodic boundary conditions, 288, 289PLLA, 290QM/MM modeled system, 292spectroscopic techniques, 291targeted molecular system, 290vibrational spectroscopic data, 289, 290

siRNAs. See Small-interfering RNAs (siRNAs)Sizing nanoparticles, liquids

commercial techniques and measuringranges, 88–89

DCS (see Differential centrifugalsedimentation (DCS))

defined, 90DLS (see Dynamic light scattering (DLS))ensemble analytical techniques, 89ESD, 88microscopy-based methods (see

Microscopy)NTA (see Nanoparticle tracking analysis

(NTA))SdFFF (see Sedimentation field flow

fractionation (SdFFF))single particle analyzers, 89static and dynamic light scattering, 90

SLA. See Stereolithography (SLA)Small-interfering RNAs (siRNAs)

CH/siRNA nanocomplexes, 196mAbs, 203nerve regeneration studies, 197oligonucleotide delivery, 190transfection, 195

SNALPs. See Stabilized nucleic acid lipidparticles (SNALPs)

Stabilized nucleic acid lipid particles(SNALPs)

animal models, Hepatitis B and Ebolainfection, 169

cationic liposome-based formulation, 169TfRs, 169

Stable free radical polymerization (SFRP), 325Stereolithography (SLA)

approach, hydrogel construct, 234, 237BMP-2-loaded microspheres, 234, 235direct/laser writing approach, 232fabrication procedure, 235, 238fluorescence confocal microscopy, 241,

242

420 Subject Index

Stereolithography (SLA) (cont.)hydrogel microstructures, living cells, 236,

240hydrogel structure, 234, 236LCD vs. DMD technologies, 233mask-based irradiation method, 233microgel assembly process, mask-based

irradiation procedure, 241, 242natural polymeric hydrogels, 233–234NGC, 236, 239photo-initiated curing reaction, 230, 232photo-initiators, 234stereo-thermal-lithography system, 236,

241two-photon-initiated polymerization

processes, 233Stimuli responsive polymers

definition, 334micellar system, 332, 333novel nanostructures, 332polymer-protein conjugates, 346

Surfactantsbilayer characteristics

bending rigidity modulus, 47description, 47Helfrich flexible surface model, 47saddle-splay modulus, 47–48

CPP and mean curvature (see Criticalpacking parameter (CPP))

description, 38phase diagrams (see Phase diagrams)properties

compartmentalization, living forms,38examples, 38, 39hydrophobic and hydrophilic, 38Zwitterionic phospholipids, 38

self-assembly and phase behavior (seeSelf-assembly and phase behavior)

structures and drug deliveryliquid crystalline phases, 49–50micelles, 48–49microemulsions, 50–51vesicles, 50

Synthetic and viral peptidesinfuenza virus hemagglutinin subunit

(HA-2), 16intracellular delivery, small

molecules/macromolecules,18

membrane destabilization, amphiphilicpeptides, 16, 17

similarities, 16transmembrane pores/channels, 18

Synthetic polymersacrylic polymers, 325biodegradable synthetic polymers, 323–324drug delivery, 324

TTargeting ligands

ability, THL, 163antibody conjugation, 163biological targeting moieties, 321cell-surface receptors and ligands,

162, 163ctDNA-FA-CLs, 164FA-associated lipoplexes, 164folate receptor (FR), 164folic acid (FA), 164nanoconjugate delivery vehicles, 345negatively charged nanocarriers, 321surface chemistry modification, 321TfR, 163

TEM. See Transmission electron microscope(TEM)

TfR. See Transferrin receptor (TfR)Therapeutic dose

blood glucose reduction, 121oral insulin, 114, 115

THL. See Trojan Horse liposomes (THL)TIL. See Tumor infiltrating lymphocytes

(TIL)Tissue engineering

crosslinked hydrophilic polymers, 227development, biological substitute, 225fundamental strategies, 226SLA, 227

Transcellular insulin pathwaynon-specific uptake, 117–118specific uptake, 118–119

Transferrin receptor (TfR)description, 163electrostatic/covalent association, 163SNALPs, 169

Transmission electron microscope (TEM)EDX detector, 93electrons penetration, 93vs. OM, 92sub-nanometer special resolution, 93

Trojan Horse liposomes (THL), 163Tumor infiltrating lymphocytes (TIL), 172

UUCLs. See Ultradeformable cationic liposomes

(UCLs)

Subject Index 421

UKPDS. See United Kingdom ProspectiveDiabetes Study (UKPDS)

Ultradeformable cationic liposomes (UCLs),168

United Kingdom Prospective Diabetes Study(UKPDS), 111

VVesicles, 50Viral vectors

and cellular nucleic acid, 190comparison, properties, 188, 189drawbacks, 190

insertional mutagenesis and oncogenesis,188

WWarburg effect

aerobic glycolysis (see Glycolysis)cancer therapy (see Cancer therapy)description, 25618-FDG PET, 256hypothesis, 256lactic acid, 261mechanism ideas, 258oxygen respiration, 261–263