MTHFR Basics - Doctor Doni...What is MTHFR? Gene and enzyme that turns folic acid into folate....

By Dr. Doni Wilson

The Answers You Need to Take Control of Your Health

MTHFR Basics

Genetics + Stress = Health

What are Stresses? Major Life Stresses

Daily StressesFood Sensitivities

InfectionsMedications

Physical TraumaLack of Sleep

Elevated Blood SugarLack of Nutrients

Toxins

Footnote

Genetics + Stress = Health

How to Read a Genetic Report?

Letters, numbers and colors.Genes code for enzymes.

Genes have 2 strands and 2 possible SNPs.Heterozygous = 1 SNP (yellow)

Homozygous = 2 SNPs (red)

We all have some SNPs!

What Are SNPs?

Genetic variations.Potential traffic jams.

What are Cofactors?

Nutrient(s) required for enzyme to function.

What is MTHFR? Gene and enzyme that turns folic acid into folate.

“Folic acid” and “folate” are often used interchangeably, but they are different.

Folate is found in nature.Folic acid is synthetic.

MTHFR A1298CMTHFR C677T

Footnote

Health Risks Associated with MTHFR? Migraines

Anxiety and DepressionMiscarriages and Neural Tube Defects

InsomniaCervical Dysplasia (abnormal pap smears)

Heart DiseaseDiabetesCancer

Alzheimer’s

What is Methylation? “B Vitamin Cycle”

What our B vitamins are up to!

Folate and B12 come together with Homocysteine to make SAM (S-adenosyl methionine).

Then SAM recycles back around to Homocysteine.

Negatively Affected by Stress.

What is SAM?

Used in the body to do all sorts of good!

Protects our DNAHelps make healthy new cells

Makes and breaks down neurotransmittersand helps get rid of histamine (think of allergies).

What is Homocysteine? Recycling SAM.

Connects up with Folate and B12.

Can also go down the glutathione pathway.Glutathione is a major anti-oxidant in our bodies -

a cell protector.

Can be measured in blood work.

What can block Methylation?

InflammationMetalsAlcohol

LPS from gut bacteriaNitric Oxide (uncoupled)

What can I do to address MTHFR?

Avoid Folic Acid.Find out if you need Folate.

What is blocking methylation?Do you have enough cofactors?

Address YOUR stress!

What tests do I need to do? Genetic panelRun software

Blood test for Homocysteine

May also need to test: SAM, sulfur, organic acids, cortisol, neurotransmitters, food sensitivities, metals, toxins, glutathione, stool/gut

bacteria, nutrient levels, methylmalonic acid

Footnote

Will Supplements Help? Which?

Yes - Important to Individualize!

Vitamin B6, MagnesiumOther B vitamins

Minerals/Electrolytes

Methyl-Folate (5MTHF)Methyl-Cobalamin (B12)

Dr. Doni’s 5-step Approach

Remove Blocks

By decreasing “stresses” in our bodies, we improve

methylation.

Stress

Inflammation

Decreased Methylation

Leaky Gut + Dysbiosis + Blood Sugar Issues

Oxidative Stress + Chronic Infection

Stress Remedy Program

Address Downstream Pathways

Sulfur & Glutathione

Nitric Oxideand

Histamine

Support Cofactors First!

MagnesiumMinerals/Electrolytes

Vitamin B6 Other B vitaminsHydroxo B12 trial

Molybdenum (if needed)

Assess Methylation

Know your homocysteine level!

Add Methylation Supportonly IF needed !!

5MTHF +

Methyl B12 +

B6 (P5P)

Subsection Text

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https://doctordoni.com/pdfs/Dr-Doni-Wilson_MTHFR-and-Genetic-Profiling-

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MTHFR Basics - Doctor Doni...What is MTHFR? Gene and enzyme that turns folic acid into folate....

Documents

The Little Known Difference Between Folate and Folic Acid

Folate Metabolism and MTHFR - Seeking Health · Folate Metabolism and MTHFR: ... DHF . Recap 1. ... pathway suffers and puts pressure on

Folate, Folic Acid, and Health - moh.govt.nzfile/PHIFolicpaper.pdf · as bread, with folic acid • supplements are an effective method to get 400mcg of folic acid, but advising

The prevalence of folate-remedial MTHFR enzyme variants in … · phy (fol3) into a met13 strain, allowing titration of intracellular folate concentrations by varying folinic acid

Birth Defect Prevention: Global Issues - who.int · in folic acid pathway RCT Case Control Fortification MTHFR Fol Receptor etc Blood folate B6 Homocysteine etc more NTDs fewer NTDs

Award Number: DAMD17-02-1-0606 TITLE: Folate and breast ... · MTHFR irreversibly converts 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, which provides the methyl group

· Web viewSPECIFIC AIMS Dihidrofolate reductase (DHFR) activity is needed to convert synthetic folic acid from fortified foods and supplements into biological folate. We have

Folate: Vitamin B-9 By: Abby Stanley. Overview Difference between folate and folic acid Dietary folate equivalents Sources RDA and Upper Limits

RESEARCH ARTICLE Open Access Folic acid supplementation, … · 2019. 5. 13. · RESEARCH ARTICLE Open Access Folic acid supplementation, dietary folate intake during pregnancy and

Maximization of Vitamin A, Folic Acid, and Other Essential ... · Folate (B9) Folic acid 5,6,7,8-tetrahydrofolates with polyglutamate side chain requiring deconjugation in the gut

Determination of Folate kappa - SLU.SE · Determination of Folate for ... forms were found using high performance liquid chromatography and mass ... folic acid, microbiological assay,

Determination of Folate kappa - SLU.SEpub.epsilon.slu.se/8567/1/strandler_hs_120125.pdf · forms were found using high performance liquid chromatography and mass ... folic acid, microbiological

Vitamin B9 (Folic acid) - Practitioner Select is also known as folate, folacin, folinic ... 18 years: 400 mcg (RDA) Adult 19 years and older: 400 mcg ... Vitamin B9 (Folic acid)

Folic acid campaigns in the Netherland: the Dutch ... · Folate intake and recommendation • Folate intake of women 19-35 years ( µg) in 1987/1988: 237.0 ± 81.0; in 1997/1998:

CHEW SIEW CHOO - Universiti Putra Malaysiapsasir.upm.edu.my/21437/1/FPSK(m)_2011_20R.pdf · Based on FFQ, the main dietary sources of folate were cereals, ... Informasi tentang MTHFR

Guide for health professionals Frequently asked …...Guide for health professionals Frequently asked questions What is folate or folic acid? Folate is a B-group vitamin that is essential

MTHFR & Genetic Basics - Doctor Doni...What is MTHFR? Gene and enzyme that turns folic acid into folate. “Folic acid” and “folate” are often used interchangeably, but they

Research Article - Hindawi Publishing Corporationdownloads.hindawi.com/journals/ogi/2012/485179.pdf · 2019. 7. 31. · folic acid was not signiﬁcantly correlated with folate intake

Folic Acid: At Work for You! Guide and Notes FINAL.pdfWelcome to the “Folic Acid: At Work for You” Program! Folic acid, or folate, is a B vitamin that, if taken before and during

Folic Acid in the Prevention of NTDs - Michigan · Where can you find folic acid? Synthetic folic acid Vitamin supplements Fortified foods Naturally-occurring food folate Certain