MTHFR Basics - Doctor Doni...What is MTHFR? Gene and enzyme that turns folic acid into folate. “Folic acid” and “folate” are often used interchangeably, but they are different

By Dr. Doni Wilson

The Answers You Need to Take Control of Your Health

MTHFR Basics

Genetics + Stress = Health

© 2017 Dr. Doni Wilson

What are Stresses? Major Life Stresses

Daily StressesFood Sensitivities

InfectionsMedications

Physical TraumaLack of Sleep

Elevated Blood SugarLack of Nutrients

Toxins


Footnote




Genetics + Stress = Health


How to Read a Genetic Report?

Letters, numbers and colors.Genes code for enzymes.

Genes have 2 strands and 2 possible SNPs.Heterozygous = 1 SNP (yellow)

Homozygous = 2 SNPs (red)

We all have some SNPs!


What Are SNPs?

Genetic variations.Potential traffic jams.


What are Cofactors?

Nutrient(s) required for enzyme to function.


What is MTHFR? Gene and enzyme that turns folic acid into folate.

“Folic acid” and “folate” are often used interchangeably, but they are different.

Folate is found in nature.Folic acid is synthetic.

MTHFR A1298CMTHFR C677T


Footnote


Health Risks Associated with MTHFR? Migraines

Anxiety and DepressionMiscarriages and Neural Tube Defects

InsomniaCervical Dysplasia (abnormal pap smears)

Heart DiseaseDiabetesCancer

Alzheimer’s


What is Methylation? “B Vitamin Cycle”

What our B vitamins are up to!

Folate and B12 come together with Homocysteine to make SAM (S-adenosyl methionine).

Then SAM recycles back around to Homocysteine.

Negatively Affected by Stress.


What is SAM?

Used in the body to do all sorts of good!

Protects our DNAHelps make healthy new cells

Makes and breaks down neurotransmittersand helps get rid of histamine (think of allergies).


What is Homocysteine? Recycling SAM.

Connects up with Folate and B12.

Can also go down the glutathione pathway.Glutathione is a major anti-oxidant in our bodies -

a cell protector.

Can be measured in blood work.


What can block Methylation?

InflammationMetalsAlcohol

LPS from gut bacteriaNitric Oxide (uncoupled)


What can I do to address MTHFR?

Avoid Folic Acid.Find out if you need Folate.

What is blocking methylation?Do you have enough cofactors?

Address YOUR stress!


What tests do I need to do? Genetic panelRun software

Blood test for Homocysteine

May also need to test: SAM, sulfur, organic acids, cortisol, neurotransmitters, food sensitivities, metals, toxins, glutathione, stool/gut

bacteria, nutrient levels, methylmalonic acid





Footnote


Footnote


Will Supplements Help? Which?

Yes - Important to Individualize!

Vitamin B6, MagnesiumOther B vitamins

Minerals/Electrolytes

Methyl-Folate (5MTHF)Methyl-Cobalamin (B12)


Dr. Doni’s 5-step Approach


Remove Blocks

By decreasing “stresses” in our bodies, we improve

methylation.


Stress

Inflammation

Decreased Methylation

Leaky Gut + Dysbiosis + Blood Sugar Issues

Oxidative Stress + Chronic Infection



Stress Remedy Program

Address Downstream Pathways


Sulfur & Glutathione

Nitric Oxideand

Histamine

Neurotransmitters© 2017 Dr. Doni Wilson

Support Cofactors First!


MagnesiumMinerals/Electrolytes

Vitamin B6 Other B vitaminsHydroxo B12 trial

Molybdenum (if needed)

Assess Methylation


Know your homocysteine level!

Add Methylation Supportonly IF needed !!


5MTHF +

Methyl B12 +

B6 (P5P)

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WEBINAR

JAN - MAR $397.00

Addressing MTHFR

with Dr. Doni’s 5 Step Approach

https://doctordoni.com/pdfs/Dr-Doni-Wilson_MTHFR-and-Genetic-Profiling-

Solutions-Package.pdf

THANK YOU!

www.DrDoni.comBlog and NewsletterMTHFR Consultation Package

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MTHFR Basics - Doctor Doni...What is MTHFR? Gene and enzyme that turns folic acid into folate. “Folic acid” and “folate” are often used interchangeably, but they are different