Biopharmaceutics Intro

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BiopharmaceuticsRachmat Mauludin

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Definition

Biopharmaceutics mempelajarihubunganatau interrelationship antara sifat fisikokimia,

bentuk sediaan obat, dan rute pemberian

terhadap kecepatan (rate) dan derajat

(banyaknya) obat yg diabsorpsi secara sistemik.

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Aspek Biofarmasi

Melindungi aktifitas obat seperti prodrug

Pelepasan obat dari sediaan Kecepatan disolusi obat pada sisi

absorpsinya

Mekanisme absorpsi obat

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Disolusi

Proces dimana molekul fase padat menunjufase larutan seperti air dan terlarut atau

Proces dimana molekul obat dibebaskan/dilepaskan dari fase padat dan masuk kedalam suatu larutan

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Cs

CDiffusionlayer

Aqueouslayer

Solidmatrix

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II. MEKANISME BIOTRANSPOR

A. Passive Diffusion

B. Biotranspor diperantarai Carrier

C. Efflux sellular

D. Pinositosis

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Processes involved in drug transport. Here the major processes are represented in a less

physiological fashion. It is with this approach that we will look at much of the course material.

The headings Absorption, Distribution, Metabolism, and Excretion are important

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Pharmacological effect

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Drug in dosage form

Release

Drug particles in body fluids

Dissolution

Drug in solutionDegradation

Absorption

Liver

Excretion

GI

Central Compartment

Free Bound

Distribution

PeripheralTissues

Pharmacologic effect

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Pharmacokinetics

Involves the kinetics of drug absorption,

distribution, and elimination (excretionand

metabolism) Drug disposition: drug distribution and

elimination

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Terminologi dalam Farmakokinetik

Peak plasma level (C max): konsentrasiobat maksimum dalam plasma, dihubungkanterhadap dosis, kecepatan absoprpsi, danKonstanta kecepatan eleminasi obat. time for peak plasma:waktu mencapaiPPL dan menjadi indikasi kecepatan rata rata

obat di absorpsi. area under the curve (AUC):berhubungan dengan jumlah obat di absorpsi.

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Pharmacodynamics

Pharmacodynamics mengarah kepadahubungan konsentrasi obat pada sisiaktifnya (receptor) dan response

farmakologi termasuk efek biokimia danfisiologi yang mempengaruhi interaksiobat dan reseptor.

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PHARMACOLOGIC EFFECT

DRUG SPECIFIC

Concentration-effect Relationship

Site of Biological Effect

Disposition of the DrugPotency of the Drug

PATIENT SPECIFICEnvironmental Exposure

Psychological Condition

Genetic Constitution

Organ Function

Enzyme Activity

REGIMEN SPECIFICDosage Form

Frequency

RouteDose

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Drug in dosage form

Release

Drug particles in body fluids

Dissolution

Drug in solutionDegradation

Absorption

Liver

Excretion

GI

Central Compartment

Free Bound

Distribution

Peripheral

Tissues

Pharmacologic effect

Pharmacodynamics

Biopharmaceutics

Pharmacokinetics