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7/28/2019 Biopharmaceutics Intro
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BiopharmaceuticsRachmat Mauludin
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Definition
Biopharmaceutics mempelajarihubunganatau interrelationship antara sifat fisikokimia,
bentuk sediaan obat, dan rute pemberian
terhadap kecepatan (rate) dan derajat
(banyaknya) obat yg diabsorpsi secara sistemik.
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Aspek Biofarmasi
Melindungi aktifitas obat seperti prodrug
Pelepasan obat dari sediaan Kecepatan disolusi obat pada sisi
absorpsinya
Mekanisme absorpsi obat
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Disolusi
Proces dimana molekul fase padat menunjufase larutan seperti air dan terlarut atau
Proces dimana molekul obat dibebaskan/dilepaskan dari fase padat dan masuk kedalam suatu larutan
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Cs
CDiffusionlayer
Aqueouslayer
Solidmatrix
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II. MEKANISME BIOTRANSPOR
A. Passive Diffusion
B. Biotranspor diperantarai Carrier
C. Efflux sellular
D. Pinositosis
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Processes involved in drug transport. Here the major processes are represented in a less
physiological fashion. It is with this approach that we will look at much of the course material.
The headings Absorption, Distribution, Metabolism, and Excretion are important
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Pharmacological effect
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Drug in dosage form
Release
Drug particles in body fluids
Dissolution
Drug in solutionDegradation
Absorption
Liver
Excretion
GI
Central Compartment
Free Bound
Distribution
PeripheralTissues
Pharmacologic effect
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Pharmacokinetics
Involves the kinetics of drug absorption,
distribution, and elimination (excretionand
metabolism) Drug disposition: drug distribution and
elimination
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Terminologi dalam Farmakokinetik
Peak plasma level (C max): konsentrasiobat maksimum dalam plasma, dihubungkanterhadap dosis, kecepatan absoprpsi, danKonstanta kecepatan eleminasi obat. time for peak plasma:waktu mencapaiPPL dan menjadi indikasi kecepatan rata rata
obat di absorpsi. area under the curve (AUC):berhubungan dengan jumlah obat di absorpsi.
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Pharmacodynamics
Pharmacodynamics mengarah kepadahubungan konsentrasi obat pada sisiaktifnya (receptor) dan response
farmakologi termasuk efek biokimia danfisiologi yang mempengaruhi interaksiobat dan reseptor.
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PHARMACOLOGIC EFFECT
DRUG SPECIFIC
Concentration-effect Relationship
Site of Biological Effect
Disposition of the DrugPotency of the Drug
PATIENT SPECIFICEnvironmental Exposure
Psychological Condition
Genetic Constitution
Organ Function
Enzyme Activity
REGIMEN SPECIFICDosage Form
Frequency
RouteDose
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Drug in dosage form
Release
Drug particles in body fluids
Dissolution
Drug in solutionDegradation
Absorption
Liver
Excretion
GI
Central Compartment
Free Bound
Distribution
Peripheral
Tissues
Pharmacologic effect
Pharmacodynamics
Biopharmaceutics
Pharmacokinetics