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“THWARTING PROTEIN PRODUCTION SLOWS CANCER CELL´S MALIGNANT
MARCH” AND “PROTEINS KEY IN STEM CELL PRODUCTION IDENTIFIED”
Manuela Rendón DíezMedicine Student
III Semester
Molecular Biology
FOLDING
FOLDING
Introduction
DNADNA
RNARNA
ProteinsProteins
actions
enzyme structural
inmunological
contractil
homeostatic
“THWARTING PROTEIN
PRODUCTION SLOWS CANCER
CELL´S MALIGNANT MARCH”
Science Daily(July 18, 2013)
“THWARTING PROTEIN PRODUCTION SLOWS CANCER CELL´S MALIGNANT MARCH”
(July 18, 2013)
Protein synthesis and cell proliferation is closely associated with the stress response.
Inhibiting translation
retards tumor growth
“THWARTING PROTEIN PRODUCTION SLOWS CANCER CELL´S MALIGNANT MARCH”
(July 18, 2013)
Heat shock factor
protein 1 (HSF1)
Increases survival despite the efforts of natural defenses
and therapeutic
help them survive and
thrive
increases protein
translation
malignancy increases
hyperactive response of cancer cells
“THWARTING PROTEIN PRODUCTION SLOWS CANCER CELL´S MALIGNANT MARCH”
(July 18, 2013)
Rohinitib (RHT)
Inhibits tumor growth
Interrupts the translation and activity
of HSF1
Suppresses glucose uptake
Personal Observation
I think that the discovery of new compounds that suppress the translational and proliferative activity of
the cells has great importance for the treatment of different cancers, or as a therapeutic alternative to reduce the
maximum pathogenesis.
“PROTEINS KEY IN STEM CELL
PRODUCTION IDENTIFIED”
Science Daily(July 5, 2013)
“PROTEINS KEY IN STEM CELL PRODUCTION IDENTIFIED”(July 5, 2013)
Pluripotent stem cells (iPSCs)
are transformed into many cell types
Useful in therapeutics
“PROTEINS KEY IN STEM CELL PRODUCTION IDENTIFIED”(July 5, 2013)
Proteins play a critical role in pluripotency
“PROTEINS KEY IN STEM CELL PRODUCTION IDENTIFIED”(July 5, 2013)
Proteins identified by the splicing code
Act as a switch
Activate and deactivate the pluripotency of stem cells
Personal Observation
I think that the development of stem cells is of great
importance to medical and scientific research, its use in regenerative medicine,
immunotherapy, gene therapy, pain relief treatments, cancer,
diabetes, cloning, set the standard in scientific
development, but, for me, it leaves much to be desired in
ethical issues.
Medical Utility
The medical importance of protein synthesis is mainly based on the
large number of functions that these play a biological level, from hormones, neurotransmitters, antibodies, enzymes, transporters, etc..
Medical Utility
Medical Utility
The development of new methods for the treatment
of diseases that are related to protein
synthesis and cell proliferation will be the
solution to future pathologies that were considered incurable.
Medical Utility
The production of stem cells will then be an
alternative for survival.
BIBLIOGRAPHY
*Martínez Sánchez, Lina María. Biología Molecular. 7 Ed. Medellín. UPB. Facultad de Medicina 2012. 102-106 pp.
*Proteins Key in Stem Cell Production Identified. Science Daily (online magazine). 2013 (July 5).
Avaliable at: http://www.sciencedaily.com/releases/2013/07/130705113622.htm
*Thwarting Protein Production Slows Cancer Cell´s Malignant March. Science Daily (online magazine). 2013 (July 18).
Avaliable at: http://www.sciencedaily.com/releases/2013/07/130718142420.htm