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Nanotechnology: Progress, Potential and PitfallsPeter HackettExecutive Professor, School of Business, University of Alberta Fellow, National Institute for [email protected]
Synthesis, Structure, and Dynamics
Borzonyi et al., …Giant Molar Ellipticity, JACS, 132 (2010) 15136
Synthesis
Structure Dynamics
The “wow” of nanotechnology
Rejecting Without Review, ACS Nano, 4, (2010) 4964
That almost indescribable “wow” factor• A subject or theme that sheds light on and gives insight
into a perplexing problem or fundamental issue, for example, a new way of looking at a material (such as a new set of properties or mechanistic understanding)
• Or an intriguing new application based on nanomaterials. • The nanomaterials and their properties must be the star
of the show.Novelty• Perhaps one of the most overused words in science, but I
will use it nonetheless. If a paper passes the “wow” test, then it is on to careful consideration of how original the work is.
NANOTECHNOLOGYPROGRESS
CANDU Nuclear Reactor
• Natural Uranium Fuel
• Heavy Water Moderator
• Internal Construction from Zirconium
Radiation Creep• CANDU fuel are 10 meters long• 30 years irradiation causes tubes to lengthen by 30cm• Since tubes are horizontal, they sag under gravity• This causes internal parts to contact and corrode• Zirconium has a low neutron absorption cross section• Five isotopes (90, 91, 92, 94, 96)• Zirconium-91 has the highest neutron cross section
SOLUTION: Remove the zirconium-91
Isotope shifts in atomic spectra
• Nuclear mass effect decreases with increasing mass
• Nuclear volume effect increases with increasing mass
• Zirconium lies in the middle of the periodic table, Atomic Number 40, and has a minimal isotope shift
QUESTION: Can hyperfine effects help?
Hyperfine coupling effects
• Zirconium 90, 92, 94, 96 have even numbers of neutrons
• All even-even isotopes have zero nuclear magnetic moment
• Only zirconium-91 will have a hyperfine shift due to the interaction of the electron spin at the nucleus
• Therefore zirconium-91 can be preferentially excited even though isotope shift is very small
SOLUTION: Use hyperfine shifts in spectra
Pulsed laser metal cluster beams
• BP Zirconium 4409 C• Smalley source for
metal cluster beams• Pulsed laser
vaporization• Supersonic cooling
LIF of Zirconium Atom Beams
Bourne et al., Opt. Comm., 56 (1986) 403
RED 16296.62 cm-1 BLUE
LIS of Zirconium Atom Beams
Humphries et al, Chem. Phy. Letters, 118, (1985) 134Mass Spectrum m/e
Excita
tion
Wav
elen
gth
Molecular Surface Science
R.E. Smalley
Comparison of Ab Initio Quantum Chemistry With Experiment: State of the Art
R.J. Bartlett (Ed.) Reidel, New York, 1985
Nanofilaments: thermionic emission
Amrein et al., J. Chem. Phys., 95 (1991) 1781
Reactivity of metal clusters…
Mitchell et al., J. Chem. Phys., 103 (1995) 5539
Molecular surface science…
Mitchell et al., J. Chem. Phys., 103 (1995) 5539
PFI-ZEKE Spectroscopy
Yang et al., J. Electron. Spectrosc. Rel. Phenom.. 106 (2000) 153
ZEKE spectroscopy of Nb clusters
Yang et al., J. Electron. Spectrosc. Rel. Phenom.. 106 (2000) 153
ZEKE spectroscopy of Nb clusters
Yang et al., J. Electron. Spectrosc. Rel. Phenom.. 106 (2000) 153
Molecular surface science…
Collings et al., J. Chem. Phys., 101 (1994) 3510
UV of AunXe and AunXe+
Molecular surface science…
Rayner et al., Phys. Rev. Lett., 74 (1995) 2070
IRMPD of Ag2NH3
Molecular surface science…
Gruene et al.. Science, 321 (2010) 675
FIRMPD of Au7Kr
Molecular surface science…
Gruene et al.. Science, 321 (2010) 675
FIRMPD of Au19 and Au20
Digital etching of nanostructures I
Bourne et al., J. Vac. Sci. Technol. B, 11(1993) 556
Digital etching of nanostructures II
Bourne et al., App. Phys A, 99 (1994) 295ETCH RATE: 0.9 monolayers per pulse
NINT: Building ($40M)
NRC/UofASharedNanotechFacility
($40M)
NRC
• ResearchPrograms
• Innovation Program
• Incubator
Adjuncts
University AlignedNanotechResearchPrograms
NRC Fellows
$2M
/a
$40M
$40M
$12
M/a
$20M
InterdisciplinaryGlobal Scale
$?M
/a
$20M
National Institute for Nanotechnology
DESIGN: Hackett and Church, early 1999
NINT announcement 2001
Nature, 412 (2001) 846
I believe so much in this model that I’ve picked an area of research I believe is fertile for Canada – quantum information theory and quantum computing – and have invested heavily in it. It’s a fresh, green valley just waiting for us to claim. I have put $133 million so far into the Perimeter Institute for Theoretical Physics and the Institute for Quantum Computing at the University of Waterloo.
Mike LazaridisCEO, Research in Motion
“
NINT and IQCSIMS NINT IQC
Established 1991 2001 2002
Age 19 9 8
Papers 3130 525 415
Citations 64945 5223 2890
Cites/paper 20.7 10 7
h-index 100 35 25
Thompson-Reuters Web-of-Science, November 2010
Growth of Institutes and Centres
Thompson Reuters Web of Science
INSTITUTE OR CENTRE COUNTRY FIRST PAPER
TOTAL PAPERS
TOTAL CITATIONS
h-index citations per paper
Glasgow Univ Nanoelectr Res Centre UK 1988 220 2683 23 12.2University of Cicinnati Nanoelectonics Lab USA 1990 48 1003 16 20.9Cornell Univ Natl Nanofab Facility USA 1990 224 4342 34 19.4Agr Univ Vienna Inst Mol Nanotechnol AUSTRIA 1991 133 3887 36 29.2Taiwan Natl Nanodevice Lab TAIWAN 1992 441 3827 30 8.7Paul Scherrer Institute Lab Micro and Nano SWITZERLAND 1993 431 7683 43 17.8Chalmers Univ Technology SWEDEN 1993 639 7364 38 11.5University of Birmingham UK 1995 316 3757 32 11.9Rice University Nano Ctr and Smalley Inst USA 1995 895 64393 116 71.9Smalley Institute USA 2005 260 3247 29 12.5University of Cambridge UK 1997 286 4948 34 17.3Forschungszentrum Karlsruhe GERMANY 1999 1490 29206 73 19.6All CAS INSTITUTES and CENTRES CHINA 2000 1363 10917 45 8.0All CNRS INSTITUTES and CENTRES FRANCE 2001 3431 34026 64 9.9University of Twente HOLLAND 2001 1285 13343 49 10.4MESA Inst Nanotechnol HOLLAND 2003 1006 9713 43 9.7NIAIST Nanotechnol Res Inst JAPAN 2001 1222 9662 41 7.9California Nanosystems Institute USA 2002 867 21165 72 24.4Purdue University Birck Nanotechnol Centre USA 2003 744 6895 36 9.3NINT CANADA 2003 539 5381 36 10.0ALL NANO INSTITUTES LISTED ABOVE 15840 247442 15.6
NANOTECHNOLOGY POTENTIAL
Institute for Quantum Computing
Institute for Quantum Computing
Three slit experiment
Sinha at al., Science, 329 (2010) 418
Nanotechnology and nanoscienceRadical Engineering• 40 nm features • Phase shifting masks• Multiple exposure lithography• Immersion optics• Short wavelength lasers• Chemically amplified resists• Chemical-mechanical polishing
George M. Whitesides, Preface, MESA+ Annual Report (2009) 6
Nanoscience• Nanostructures in the cell• Nanomaterials• Quantum materialsApplications• Nanobiomedicine• Quantum computing• Single-molecule transistors• Membranes with designed pores• Heterogeneous catalysts• Aerosols and nanoparticles
Single tungsten atom STM tip…
Rezeq, Pitters and Wolkow, J.Chem. Phys., 124 (2006) 204716
In-line holographic electron microscopy in presence of magnetic fields
Livadru, Mutus and Wolkow, Ultramicroscopy, 108, (2008) 472
… enables atom-resolving holographic microscope
D. Gabor, Nature, 161 (1948) 777
Molecular electronics
Piva et al., Nature, 435 (2005) 658
Molecular Transistor
•One electron on one atom can act as valve
•Electrons flow through one molecule
Significance
•A very low energy event (single charged atom) can control circuit flow of small number of electrons
• less energy, less heat
Needs engineering solutions
Still not portable devices…
Wolkow Group, NRC National Institute for Nanotechnology
…but neither was the transistor in the beginning
A new concept for computing
Controlled Coupling and Occupation of Silicon Atomic Quantum Dots
M. Baseer Haider, J ason L Pitters, Gino A. DiLabio, Lucian Livadaru, J osh Y Mutus, Robert A. Wolkow
At room temperature
May 19, 2010 41
Wolkow Group, NRC-NINT
A taxonomy for nano-information processing technologies
International Technology Roadmap for Semiconductors, 2009
Charge qubit quantum computing
Livadaru et al., New J. Phys., 12 (2010) 083018
“…extremely high tunneling rate, 1014s-1, greatly exceeds expected decoherence rates for a silicon-based system, thereby overcoming a critical obstacle of charge qubit quantum computing.”
5 – 10 nanometre silver particles grown by new, proprietary,
economical technique
Crystalline atomic planes visible under extreme
magnification
Electron diffraction proves planes are crystalline
metallic silver
Kuznicki et al. Microporous Mesoporous Mat, 103 (2007) 309
Low cost crystalline nanosilver
Silver ion-exchanged sedimentary chabazite annealed at 400 oC
Synthetic platy chabazites
Kuznicki et al, Clay and Clay Minerals, 56 (2008) 655
(a) Synthetic chabazite analog (b) Mineral chabazite
.
Alberta NanometalsApplications• wound management• anti-microbial paints & coatings • air & water filtration• rare gas capture/production• conductive inks• water purification • catalytic applications• mercury capture from flue gas
of coal fired power plants
PolyBAIT technology platform
Kitov et al., PNAS, 105 (2008) 16837
Toxin
Template Drug
Applications of PolyBAIT technology
• Eliminating bacterial toxins• Nanotech devices for targeting cancer and infections• Research tools for intracellular delivery of antibodies and
other multivalent proteins• Analytical and diagnostic tools.• Immobilization of drugs for detection using nanotechnology
Starfish inhibitor for Shiga toxins
Kitov et al, Nature, 403 (2000) 669
Shiga toxin(Stx)
Serum amyloid P component(SAP)
OO
OHO
HOOH
OHO
OH
OH
OOHHO
HOHO
OHO
OMe
O OH
HO
Ligand:Pk-trisaccharide
Ligand:1,3-glycerol pyruvate
Inhibitors for Shiga toxin
Polymeric hetero-bifunctional ligands
Kitov et al., PNAS, 105 (2008) 16837
Inter-operative MRI
Sutherland et al., IEEE Engineering in Medicine and Biology, (2008) 65
Inter-operative MRI and Neuroarm
Sutherland et al., IEEE Engineering in Medicine and Biology, (2008) 65
Core-shell nano-particles
Ma et al., Chem. Mater., 18 (2006) 1923
FexOy@SiO2
Paramagnetic cores with fluorescent shells
Ma et al., Chem. Mater., 18 (2006) 1923
FexOy@SiO2@SiO-Rubpy
Zhang et al., Physica B, 404(2009) 3666
Gold coated paramagnetic particles
The possibility of single cell surgery
• Immune targeting using nanoparticles• Inter-operative MRI (IMRIS)• Magnetic visualization and activation• Fluorescent visualization and activation• Robotic intervention (Neuroarm)• Precision surgery approaching single cell
Chimigen® Platform Technology
A New Concept in Vaccine DevelopmentDendritic cell receptor-targeted vaccines
Why Target Dendritic Cells?Dendritic cells play a central role in generating immune responses
Rajan George, CTO, Paladin Biosciences
58
S-S
S-S
S
S
Antigen
Peptide Linker
Portion of CH1
Hinge Region
Xenotypic(Murine) Fc
CHOCH2
IRD
TBD
6xHis
CH2
CHO
CH3
CH2
Antigen
6xHis
CH3
S
S
S
S
S
S
S
S
Peptide
CHOCHO
Chimigen® Platform Technology• Characteristics of both antigen and antibody• Xenotypic antibody fragment makes whole molecule
“foreign” and more immunogenic• Adaptable platform can incorporate any antigen • Designed to generate broad immune responses both
cellular and humoral • Potential uses for prophylactic & therapeutic
vaccines
Rajan George, CTO, Paladin Biosciences
59
Chimigen® Platform TechnologyNanoparticle properties • RNAi platform, delivery, gene silencing • No added adjuvant, effective at low doses (µg)• Targets different cell types• Targets multiple receptors on antigen presenting cells
especially dendritic cells (Fcγ, Lectin Receptors)Production in Insect Cells • Imparts non-mammalian glycosylation• Binding and uptake through lectin receptors• Highly immunogenic
Rajan George, CTO, Paladin Biosciences
60
S-S
S-S
S
S
Antigen
Peptide Linker
Portion of CH1
Hinge Region
Xenotypic(Murine) Fc
CHOCH2
IRD
TBD
6xHis
CH2
CHO
CH3
CH2
Antigen
6xHis
CH3
S
S
S
S
S
S
S
S
Peptide
CHOCHO
Malaria Vaccine AntigensCircumsporozoite surface protein (CSP) • Liver stage antigen • Major surface antigen of sporozoites• Involved in hepatocyte invasion
Liver stage antigen-1 (LSA-1)• Liver stage antigen• Protein secreted by sporozoites in
the parasitophorous vacuole • Protective during maturation
Apical membrane antigen-1 (AMA-1)• Blood stage antigen• Merozoite surface protein • Binds to erythrocytes and orients
the parasite for invasion
Merozoite surface protein (MSP-1) • Blood stage antigen• Merozoite surface protein cleaved
into several fragments by PfSUB 1 and 2 enzymes
61
Rajan George, CTO, Paladin Biosciences
Chimigen® Malaria Vaccine
Rajan George, CTO, Paladin Biosciences
62
S-S
S-S
S
S
Malaria antigens(CSP/AMA-1/LSA-120 repeats/MSP-142)
HBV Core
Peptide LinkerPortion of CH1
Hinge Region
Xenotypic(Murine)Fc
CHOCH2
IRD
6xHis
CH2
CH3
CH2
6xHis
CH3
S
S
S
S
S
S
Peptide
CHO
CHO CHO
Malaria antigens(CSP/AMA-1/LSA-120 repeats/MSP-142)
HBV Core
TBD
Multi-antigen vaccine
Targets parasite at various stages of the infection
Two prophylactic/therapeutic vaccine candidates
Chimigen® Malaria Three Antigen Vaccine– Completed laboratory pre-clinical studies
Chimigen® Malaria Four Antigen Vaccine– Currently in pre-clinical studies– Proposed for further development
Rajan George, CTO, Paladin Biosciences
63
S-S
S-S
S
S
Antigen
Peptide Linker
Portion of CH1
Hinge Region
Xenotypic(Murine) Fc
CHOCH2
IRD
TBD
6xHis
CH2
CHO
CH3
CH2
Antigen
6xHis
CH3
S
S
S
S
S
S
S
S
Peptide
CHOCHO
TECHNOLOGY TO MARKET
Commercialization pathways
Commercialization pathwaysResearch Commercialization Pathway Comment
Low cost nanosilver ALBERTA NANOMETALS UofA Spin off
Single atom electron source MNE co-development NRC-NINT
Automated cellular automata Venture Capital Sought NRC-NINT
Silicon charge qubit
Inter-operative MRI IMRIS INC (TSE) UofC NRC Spin Off
Robotic surgery NEUROARM INC UofC Spin Off
PolyBAIT THERACARB UofA Spin Off
Chimgen nanoparticles PALADIN BIOSCIENCES UofA Spin Off
I have mentioned that we should be looking at greater change, research of greater global relevance, and I have used my words carefully… I urge each of us to work together to make this possible in its true form where this institute not only files major numbers of patents compared to what it did before, not only pursues technical excitement, but actually contributes to a new way of life both in India but also elsewhere.
Ratan TataPresident, IISc CourtIndian Institute of Science
“
MESA+ must remind industry of the cruel and conveniently overlooked fact that when it focuses on the comfortingly familiar activities of cash management, engineering improvement of existing ideas and commoditization of its products, it loses proprietary advantage , cost advantage, margin, and ultimately the business itself. Universities and industry must cooperate – to mutual advantage – around nano to keep fresh ideas and fresh minds coming.
George M. WhitesidesHarvard UniversityMESA+ Scientific Advisory Board
“
… the students as graduates will commercialize everything they learn – whether discovered in Canada or discovered somewhere else. They will form the society of our future based on the education they’ve experienced.
Mike LazaridisCEO, Research in Motion
“
In the 20-year history of Research In Motion, I have licensed exactly two technologies from university research teams. Over that same period I have hired more than 5,000 students as co-ops, interns, and full time employees. I’ve even hired some of their professors. When I decided to build radios and introduce CAD into our engineering processes, I didn’t go looking for patents. I went looking for great people and found them in our universities.
Mike LazaridisCEO, Research in Motion
“
NANOTECHNOLOGYPITFALLS
Popular Press
Lori Sheremeta: National Institute for Nanotechnology
Early days of nano-agriculture• Research opportunities
identified• Environmental processing• Plant/animal production• Bio processing
foods/industrial products• Biosensors (biosecurity)• Sustainable agriculture
Lori Sheremeta: National Institute for Nanotechnology
Anticipated applications in NA…
Lori Sheremeta: National Institute for Nanotechnology
• Attempt to identify and catalogue research projects and associated products
• Aims to lay groundwork for orderly entry of NT into the marketplace
• Searchable db available online at: http://www.nanotechproject.org/inventories/agrifood/
…and Europe
Lori Sheremeta: National Institute for Nanotechnology
• NT has the potential to dramatically impact the agrifood sector
• Food safety is the primary concern; NT has role in sensing applications, antimicrobial coatings etc.
• NPs in food raise particular concerns; pre-market safety must be assured
But…
Lori Sheremeta: National Institute for Nanotechnology
Viruses are nanotechnology
http://www.youtube.com/watch?v=MBIZI4s5NiE
AcknowledgementsNRC National Institute for Nanotechnology•Jilian Buriak•Hicham Feniri•Nils Petersen•Lori Sherameta•Robert WolkowUniversity of Alberta•David Bundle•Steve KuznickiPaladin Biosciences•Rajan George
NRC Steacie Institute for Molecular Sciences•David Rayner•Steven Mitchell•Benoit Simard•Orson BourneNRC Industrial Materials Institute•Teodor VeresUniversity of Calgary•Garnette SutherlandUniversity of Waterloo IQC•Ray Laflamme
The beauty of nanotechnology
Come to Canada
Nanotechnology: Progress, Potential and PitfallsPeter HackettExecutive Professor, School of Business, University of Alberta Fellow, National Institute for Nanotechnology
LINKED IN CONNECTIONS WELCOMED
Many men easily do without truth but none is strong enough to do without illusions.
Gustave Le Bon (1841-1931)French social psychologist
“
Technology Development Strength
Nan
ote
chn
olo
gy
Act
ivit
yRating Nations on Nanotechology
David Hwang, Lux Research, August 2010
Emergence of China
Thompson Reuters Web of Science
Emergence of India
Thompson Reuters Web of Science
By 2004 quality is uniformly highCOUNTRY PAPERS PUBLISHED
IN 2004CITATIONS RECEIVED
CITATIONS PER PAPER
h-index
USA 8163 226804 27.8 174
CHINA 4293 76727 17.9 94
JAPAN 3253 60696 18.7 87
GERMANY 2399 50621 21.1 92
FRANCE 1603 34432 21.5 72
S KOREA 1489 25437 17.1 69
INDIA 805 14668 18.2 51
Thompson Reuters, Web of Science