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Sara Berdugo MesaMedicine Student
3rd Semester Universidad Pontificia Bolivariana
A KEY PROCESS IN THE REPLICATION,
ELUCIDATE A MECHANISM FOR CANCER.
FOLDING
FOLDING
INTRODUCTION
Although cancer is still being a genetic paradigm, nowadays it is believe that is related with factors that alters the replication enzimatic activity and creates mutations given by the cell stress.
KEY STEP IN MOLECULAR ‘DANCE’ THAT DUPLICATES DNA DECIPHERED.
Understand the machinism of an irregular DNA duplication and the uncontrolled division could be the future for the cancer treatment.
There are proteins like ORC (origin recognition complex) that may originate conformational changes binding to the molecule that is going to be replicated.
KEY STEP IN MOLECULAR ‘DANCE’ THAT DUPLICATES DNA DECIPHERED.
ORC
Multiproteinic complex that is compound by 6 proteins.
Interacts with molecules at atomic level.
KEY STEP IN MOLECULAR ‘DANCE’ THAT DUPLICATES DNA DECIPHERED.
ORC
Facilitate the helicase
binding to DNA.
It is similar to other proteint that holds the
DNA polymerase.
Improves the replication.
KEY STEP IN MOLECULAR ‘DANCE’ THAT DUPLICATES DNA DECIPHERED.
PERSONAL COMMENTS.
The genetic material is the most important target in the cancer genesis,
because the cell ignores the mechanisms of growing, proliferation
and death.
It would be a good strategy to find drugs that act either in the helicase
and DNA polymerase in order to achive a control in the replication process and
regulate the cell for the cancer treatment.
BCM SCIENTIST UNRAVEL MYSTERY BEHIND DNA BREAKS IN
RESTING CELLS.
CancerCancer genesis
Induced changes
Mutations
Oncogenes
Acelerete the cell
growing and division
DNA breaking
Genomic destabilization
The brakings may happen in normal conditions to resting cells that not replicate and have a fragmented DNA.
BCM SCIENTIST UNRAVEL MYSTERY BEHIND DNA BREAKS IN
RESTING CELLS.
All starts when the replication fork is generated, where each DNA strand separetes. The first one is manipulated by the DNA polymerase and generates a new strand, the second one is copied and generates two chromosomes, this leads to DNA breaking by a crash between DNA and RNA polymerase..
BCM SCIENTIST UNRAVEL MYSTERY BEHIND DNA BREAKS IN
RESTING CELLS.
The DNA breaking can not happen in the replication, so it makes by R-LOOP, that generates double partitions and makes the traduction a fragile moment.
BCM SCIENTIST UNRAVEL MYSTERY BEHIND DNA BREAKS IN
RESTING CELLS.
PERSONAL COMMENTS.
It is fundamental to make new studies like this to achive knowing the points where the
breaks occur, or the points that are fragile for a possible mutation. In this way we can
avoid treatments resistance in diseases like cancer and others where the alteration is
given by a genomic destabilization.
MEDICAL UTILITY
Although the initial cause is unknown, is clear that if a normal cell becomes cancerous and transmitted to their descendants, the change is given at the level of genetic material.
MEDICAL UTILITY
Is important to do experiments to discover new white dots and know that way you can try and repair the alteration.
MEDICAL UTILITY
These is important to generate treatments that
without any doubt be able of attack the target and stop the
replication problem.
.
MEDICAL UTILITY
The purpose of these experiments is to find solutions to problems and to generate drugs that help give a better quality of life to people.
BIBLIOGRAPHY• Key step in molecular ‘dance’ that duplicates DNA deciphered. Science newsline biology; 2013 [cited 2013 Julio 14]; Available from: http://www.sciencenewsline.com/summary/2012071422-120006.html.
• BCM Scientists Unravel Mystery Behind DNA Breaks In Resting Cells. Bionews Texas; 2013 [cited 2013 Julio 17]; Available from: http://bionews-tx.com/news/2013/07/17/bcm-scientists-unravel-mystery-behind-dna-breaks-in-resting-cells/.
