DNA-Protein interactions

Specific interactions Non- Specific interactions

Transcription factorsDomains of Transcription factors1. Helix loop helix2. Leucine zipper3. Zinc fingefr motif4. Lambda repressor

ChromatinNucleosomeChemical modifications byMethylationDemethylationAcetylationPhosphorylation

Protein–DNA interactions are when a protein binds a molecule of DNA, often to regulate the biological function of DNA, usually the expression of a gene. Among the proteins that bind to DNA are transcription factors that activate or repress gene expression by binding to DNA motifs and histones that form part of the structure of DNA and bind to it less specifically.

1. Transcription factors

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Leucine zipper

LZ formed by the dimerization of two specific alpha helix monomers bound to DNA. The bZIP interacts with the DNA via its N-terminal, where the lysines and arginines are located; these basic residues interact in the major groove of the DNA, forming sequence-specific interactions

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Non-specific interactions

Histone modification