SPOT-ON SKIN LIPID COMPLEX AS AN ADJUNCT THERAPY IN DOGS WITH ATOPIC DERMATITISAN OPEN PILOT STUDY

Elin Põldemaa2011

OUTLINEIntroductionMethodsResults ConclusionsRefrences

INTRODUCTION

Atopic dermatitis (AD) is a common allergic skin disease in both people and dogs

The treatment of dogs with AD is complex and lifelong

The aim of this study was to evaluate the clinical benefits of topical Spot-On Skin Lipid Complex (SLC) in the treatment of dogs with chronic AD

The study took place in Fujimura Animal Allergy Hospital, Japan, from September 2009 to December 2009

METHODS

The investigators recruited 8 dogs from their hospital with a diagnosis of chronic AD and persistent pruritus despite therapy.

The dogs were treated with SLC topically as adjunct therapy for 12 weeks. 

A topical SLC product containing ceramides, cholesterol and free fatty acids was applied at a dose of 2 mL twice weekly, by applying several drops on the head, inter scapular area, and directly on lesion sites

RESULTS

After 6 weeks of SLC treatment, a substantial improvment in the dogs condition occured

It was caused by the reduction in the erythema (36.2%, p<0,005),  excoriation (39,9%, p<0,05) and alopecia subscores (19.9%, p<0,05).

There were no markable advances in the treatment of lichenification as the decrease rate was statistically unimportant.

For the evaluation of the efficency of SLC therapy, the third version of the Canine Atopic Dermatitis Extent and Severity

Index (CADESI-03) modification was used

Clinical characteristics of Dog 5 at start of the treatment (D0)

6 weeks after D0

12 weeks after treatment

The dog was treated continuously after the completion of the trial. Clinical symptoms improved 18 weeks after D0.

CONCLUSIONS

The results of this study suggest that topical SLC application is beneficial when used in the management of canine AD. Topical lipid applications are not effective as

monotherapy but as an adjunct therapy they may bring new hope in the treatment of canine AD

Although the findings are encouraging, double-blinded placebo-controlled or cross-over studies are needed to confirm the results. 

The drug-sparing effects of SLC applications also deserve further investigation

REFRENCES

“Spot-On Skin Lipid Complex as an Adjunct Therapy in Dogs with Atopic Dermatitis: An Open Pilot Study“Masato Fujimura, Yoshinobu Nakatsuji, Subaru Fujiwara, Christophe Rème and Hugues GattoVeterinary Medicine International, Volume 2011 

http://www.hindawi.com/journals/vmi/2011/281846/

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