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Kopnolia (Magnolol) helps Anti-aging for face and eye contour. Kopnolia (Magnolol) work as Anti-redness skin care. Kopnolia (Magnolol) protects skin against chronic inflammation.
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KOPNOLIA(MAGNOLOL)Multifunctional Ingredient
KOPNOLIA (MAGNOLOL)
PRODUCT INFORMATION
IUPAC : Allyl-2-(5-allyl-2 hydroxyphenyl)phenol
Chemical Name : 5,5’-Diallyl-2,2’-biphenyldiol
Molecular Formula : C18H18O2
CAS No. : 528-43-8
Molecular Weight : 266.334
Appearance : Off white powder
PRODUCT BRIEF
Kopnolia is the trade name for Synthetic Magnolol indigenously developed by KOPL as a potent antioxidant for skin
care topical formulations. Kopnolia (Magnalol) is 5,5’-Diallyl-2,2’-biphenyldiol, a biphenyl structure containing two
allyl groups beneficial for increasing the affinity towards endothelial cells. It is known to possess some special abilities
like, it inhibits NF-kB pathway [1], NADPH oxidase [2], and activates the retinoid receptor [3], glutathione-S-
transferase, and other anti-oxidative enzymes [4]. It acts as antioxidant to suppress the oxidation of low-density
lipoprotein [5] because of high radical-scavenging activities [6].
Kopnolia can be used in crème, lotion, and serum formulation to protect skin against chronic inflammation and
reduction of skin redness. As it is capable to inhibit NF-kB pathway, it plays a very major role in neutralizing internal
aging factors. KOPL has studied the antioxidant properties of Kopnolia and Kopnolia crème comparing with other
antioxidants(Complete data available on request)
ADVANTAGES
Ÿ Physical state is solid
Ÿ Better storage stability
Ÿ Better anti-oxidant activity(7 Times > Vitamin E)
Ÿ Easy transportation
Ÿ Better solubility characteristic
Ÿ Cost
CLAIMS
ŸProtects skin against chronic inflammation
ŸNeutralizes internal aging factors
ŸReduces skin redness
APPLICATIONS
ŸAnti-aging for face and eye contour
ŸProtective formulas
ŸAnti-redness skin care
REFERENCES
Hua, Anti-inflammatory bioactivities of honokiol through inhibition of protein kinase C, mitogen-activated protein kinase, and the NF-kB pathway to reduce LPS-induced TNFa and NO expression, J. Agric. Food Chem. 58 (2010) 3472e3478.
Smallmolecule inhibitors of NADPH oxidase 4, J. Med. Chem. 53 (2010) 6758e6762.
Identification of a naturally occurring rexinoid, honokiol, that activates the retinoid X receptor, J. Nat. Prod. 73 (2010) 1332e1336.
Anti-clastogenic effect of magnolol on benzo(a) pyrene-induced clastogenicity in mice, Food Chem. Toxicol. 46 (2008) 694e700.
Protective effects of honokiol against oxidized LDL-induced cytotoxicity and adhesion molecule expression in endothelial cells, Chem.-Biol. Interact. 161 (2006) 1e13.
Organosolv ethanol lignin from hybrid poplar as a radical scavenger: relationship between lignin structure, extraction conditions, and antioxidant activity, J. Agric. Food Chem. 54 (2006) 5806e5813.
MARKETING
ŸPreservative-free and alcohol-free
Ÿ Ideal for sensitive skin
SOLUBILITY DATA
Ÿ0.1 gm of Magnalol is soluble in 1 ml of TEA.
Ÿ0.1 gm of Magnalol is soluble in 1 ml of 2% NaoH aqueous solution.
Ÿ0.1gm of Magnalol is soluble in 0.5 ml of Ethoxydiglycol
Ÿ0.1gm of Magnalol is soluble in 1 ml of Peg 8 caprylic capric triglyceride.
Ÿ15 mg of Magnalol is soluble in 10 ml of Methanol.
0
0.5
1
1.5
2
2.5
3
0 2 4 6
Concentration of free hydoxyl radicals -Kopnolia
Concentration of free hydroxyl radicals -Vitamin E
Concentration of free hydroxyl radicals -Ascorbic Acid
100
100
98
95
92
90
87
85
75
72
72
100
97
95
90
80
74
67
60
45
43
40
ANTI-OXIDANT STUDIES OF KOPNOLIAMEASUREMENT OF HYDROXYL RADICAL SCAVENGING EFFICIENCY
Concentration(mM)
Concentration in Free Hydroxyl radicals[OH]/[OH]0
MagnololVitamin E(Standard)
Ascorbic Acid (Std)
0 1 1 1
1 0.77 1.27 2.5
2 0.55 1.53 2.3
3 0.43 2.17 1.9
4 0.31 1.64 1.7
5 0.19 1.3 1.2
Concentration of free hydroxyl radical [OH]/OH]0
Concentration of free superoxide radical anions [O2]0/ [O2]
Magnolol(Series 1)
Vitamin E (Standard) (Series 2)
Ascorbic Acid (Std) (Series 3)
1 1 1
0.82 0.87 0.9
0.67 0.79 0.85
0.48 0.71 0.79
0.25 0.65 0.73
0.19 0.59 0.65
Conclusion: Conclusion: The Hydroxyl radical in case of Kopnolia cream results 7 times better than Vitamin E Cream
HYPOXANTHINE XANTHINE OXIDASE TEST
Conclusion: Conclusion: The Hydroxyl radical in case of Kopnolia cream results 3 times better than Vitamin E Cream
Concentration of free superoxide radical anions [O2]0/O2]
0
0.2
0.4
0.6
0.8
1
1.2
0 10 20 30
"Kopnolia"
"Vitamin E"
"Ascorbic Acid"
PHOTOSTABILITY STUDIES
Conclusion: Conclusion: The Hydroxyl radical in case of Kopnolia cream results 7 times better than Vitamin E Cream
Vitamin E (Standard)MagnololTime (Hrs)
Percentage of remaining molecules
0
1
2
3
4
5
6
7
23
24
25
0
20
40
60
80
100
120
0 10 20 30
Kopnolia (292nm)
Vitamin E (292nm)
Time (in hrs)
Percentage of remaining molecule
HYDROXY RADICAL SCAVENGINGEFFICACY
0
0.5
1
1.5
2
2.5
-2 0 2 4 6 8 10
Concentration in Free Hydroxyl
radicals [OH]/[OH]0 at 532nM
Magnolol based cream
Concentration in Free Hydroxyl
radicals [OH]/[OH]0 at 532nM
Vitamin E acetate based cream
Concentration in Free Hydroxyl
radicals [OH]/[OH]0 at 532nM
Placebo based cream
Linear (Concentration in Free
Hydroxyl radicals [OH]/[OH]0 at
532nM Magnolol based cream)
Linear (Concentration in Free
Hydroxyl radicals [OH]/[OH]0 at
532nM Magnolol based cream)
Conclusion: The Hydroxyl radical in case of Kopnoli cream results 3 times better than Vitamin E cream
Singapore Office
Kumar Organic Products (S) Pte. Ltd.
The Octagon, 105, Cecil Street, #07-01 - Centennial Business Centre
Singapore - 069534 Ph. : +65 3157 1525 Fax: +65 6336 6933 E-mail : [email protected]
website : www.kumarorganic.net
USA Office
Kumar Organic Products Ltd.
Suite M, ITM Corporate Center6 Kilmes Road, Edison, NJ 08817, USA
Phone : 732 662 2654Fax : 201 604 6727
E-mail : [email protected]
Head Office
Kumar Organic Products Limited
Usha Krishna Centre, 819/C, 13th Cross, 7th Block, Near JSS College Circle
Jayanagar, Bangalore - 560 041. Karnataka, INDIATel. : 080 - 41425832 / 41425832
Fax : + 080-26715688
E-mail : [email protected]@kumarorganic.net
EUROPE Office
Kumar Organic Products Ltd.
MLS Business Centres41 King Street, Luton, UK
Bedfordshire, Lu1 2DWPh. : 0044 1582345334
Fax : 0044 1582724986E-mail : [email protected]
0
20
40
60
80
100
120
0 10 20 30
Percentage of remaining molecules (292nm) for moisturizing cream Placebo
Percentage of remaining molecules (292nm) for moisturizing cream Magnolol
Percentage of remaining molecules (292nm) for moisturizing cream Vitamin E acetate
PHOTOSTABILITY
Conclusion: The photostability of Kopnolia moisturising cream is 3 times more stable compared to Vitamin E acetate moisturising cream
0
0.2
0.4
0.6
0.8
1
1.2
0 5 10 15 20 25
Concentration of free superoxide radical anions [O2]0/ [O2] at 560 nM Magnolol based cream
Concentration of free superoxide radical anions [O2]0/ [O2] at 560 nM Vitamin E acetate based cream
Concentration of free superoxide radical anions [O2]0/ [O2] at 560 nM Placebo based cream
HYPOXANTHINE XANTHINE OXIDASE TEST
Conclusion: The Hydroxyl radical in case of Kopnolia cream results 3 times better than Vitamin E Cream
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