Upload
jescarra
View
117
Download
1
Embed Size (px)
DESCRIPTION
Simposyum BRN Barcelona about personalized medicine Practical issues
Citation preview
1
Implications for the Health Care SystemJoan Escarrabill MD PhDChronic Care Program– Barcelona Esquerra. Hospital Clínic (Barcelona)
Master Plan for Respiratory Diseases (PDMAR) & Home Respiratory Therapies Observatory (ObsTRD). FORES. Ministry of Health (Catalonia)
Implications for the Health Care System
2
Sustainability
AccessibilityOutcomes
3
Am J Prev Med 2012;42:639–45
Balanced strategies that implement both population and individual-level interventions:
can best maximize health benefıts, minimize harm, avoid unnecessary healthcare costs.
P5 = Population perspective Premature translation
Lost in translation
Harm
Cost
Disparities
4
P4 Components Population perspectives
Predictive Ecologic model of Health, integrating multilevel determinants of health
Preventive Principles of population screening
Personalized Principles of evidence based medicine
Participatory Essential public health functions (assessment,policy development and assurance).Information system
Am J Prev Med 2012;42:639–45
Common pratincole
Grey heron
Personalization and Health Care: 5 elements to discuss
5
Variability
Individual vs. population
Business model
Results
Dissemination
6
The requirements for variation
Copious
Small in extentUndirected
Charles Darwin(1809-1882)
Variations in clinical practice
7
Science 1973;182-1102-09 There are wide variations in resource input, utilization of services and expenditures.
Variations indicate that there is a considerable uncercertaunty about the effectiveness of health services
Discharge ratio in surgical procedures
8
Source: Methodology of Atlas of Variations in Medical Practice Catalan Agency for Quality and Healthcare Assessment (AQuAS) http://goo.gl/wwI6jh
Long-term Oxygen therapy (LTOT) 2012/13n:
RV:
CSV:
EB:
26805 350 3704 5995 16756
5.44 9.79 25.59 11.10 7.51
0.34 3.18 0.44 0.47 0.41
0.27 0.94 0.31 0.30 0.29
-3
-2
-1
0
1
2
3T
axa
esc
ala
log
arítm
ica
mitj
ana
0
Tots 20-39 anys 40-64 anys 65-74 anys 75+ anysO2 concentrador+liquid
Source: Catalan Agency for Quality and Healthcare Assessment (AQuAS) & Home Respiratory Therapy Observatory (ObsTRD / FORES) 9
Standardized rates LTOT 2012/13
p(14): 120.17
p(86): 367.99
Ciutat de Barcelona
O2 concentrador+liquid 2012
10
Source: Catalan Agency for Quality and Healthcare Assessment (AQuAS) & Home Respiratory Therapy Observatory (ObsTRD / FORES)
Home mechanical ventilation by age-groups 2012/13
n:
RV:
CSV:
EB:
3738 200 1138 1049 1351
22.94 6.20 14.35 19.90 62.14
0.37 1.08 0.96 0.54 0.59
0.34 0.72 0.50 0.33 0.47
-3
-2
-1
0
1
2
3
Ta
xa e
sca
la lo
gar
ítmic
a m
itjan
a 0
Tots 20-39 anys 40-64 anys 65-74 anys 75+ anysVent. Mecànica
Source: Catalan Agency for Quality and Healthcare Assessment (AQuAS) & Home Respiratory Therapy Observatory (ObsTRD / FORES)
Home mechanical ventilationStandardized rates 2012/13
p(14): 7.75
p(86): 56.22
Ciutat de Barcelona
Vent. Mecànica 2012
12
Source: Catalan Agency for Quality and Healthcare Assessment (AQuAS) & Home Respiratory Therapy Observatory (ObsTRD / FORES)
13
LTOT HMV
The same accessibilityNo financial issues
Social inequalities
14
Ann Intensive Care. 2014;4(1):2. doi: 10.1186/2110-5820-4-2
Personalization and Health Care: 5 elements to discuss
15
Variability
Individual vs. population
Business model
Results
Dissemination
16
Better value through population and personalised medicine.
J A Muir Gray. Lancet 2013;382:200-1
Effectivity
Quality
Safety
Value
Presonalised
Population
medicine
Customize evidence Biomarkers Personal values Clinical situation Context
Responsibilities to the population to be served Avoid inequalities Distribution of resources
17
Comparative effectiveness research
• Overall benefits• Majority of patients• Establish population
averages
Personalized medicine
• Subsets of patients• To exploit differences
among subpopulations
Improve health care outcomesRationalize costs
18
Even today, countries with more social provision of healthcare and less individualistic attitudes have better health outcomes across all social classes.
How can we balance the role of the individual and the communal in healthcare?
Personalization and Health Care: 5 elements to discuss
19
Variability
Individual vs. population
Business model
Results
Dissemination
Disruptive business model
Solution shop
Intutive Medicine for unstructured
problems
Hypothesis testing until diagnosis can
be made
Value-added process
Empirical medicine
Standardization
Facilitated network
Patient groups with common needs
Long-term care: adherence
20
Personalized medicine
Focus on results
21
Precision medicine
Care plan: adherence
Disruptive business model
• Changes in the role of health professionals.
• Implication of new professions
22
Lancet 2013;382:923-4
Increase (emergency)
admission
Reduction LOS
Pts > 85 yrsMultimorbidity
Cognitive impairementBalance
23
Lancet 2013;382:923-4
Increase (emergency)
admission
Reduction LOS
Pts > 85 yrsMultimorbidity
Cognitive impairementBalance
To identify the optimumcare pathway for adults with medical illnesses
24
Future hospital
Hospitals must be designed around the needs of patients
No “one size fits all” : Coordinated mangement of patients with multiple comorbidities
Specialist medical care will not be confined to inside the hospital walls.
Continuity of care
Illnes can occur in any time: 24/7/365.
Reorganisation of ‘front door’
Vulnerable patients.
Patient experience is valued as much as clinical effectiveness
Three elements
25
Acute care hub
Clinical coordination
center
“Hub & spoke”
Fast track
Ann Intern Med. 2012;157:448-449.
Personalization and Health Care: 5 elements to discuss
26
Variability
Individual vs. population
Business model
Results
Dissemination
27
Value =Outcomes
Cost
NEJM 2010;363:2477-81
28
Int J Epidemiol. 2010;39:97-106
Factors at multiple levels may influence health and disease,
Interrelation among these factors often includes dynamic feedback and changes over time ObesityGenes
Individual behavior
Neighbourhood
School level
Health Policies
food portions, dietary habits,exercise,television-viewing patterns
availability of grocery stores, suitability of the walking environment,advertising of high caloric foods
29
Int J Epidemiol. 2010;39:97-106
The impact of investing in good food stores on body mass index (BMI),
Agent’s diet
Availability of good food stores
Her education level,
The diet of her parents and friends
Genetic predispositions
Importance of friend networks
Chronic care related to patients’ needs
30
Health Affairs 2013;32:516–525
Identifying the needs of patients
Needs change over time
Social & Health needs
Technical complexity
Cognitive disorders
Multiple nedds (multimorbidity)
Barriers to access
Nursing home / Hospice
Frail patients (“potential risks”)
Post-discharge support
Organ failure
Personalization and Health Care: 5 elements to discuss
31
Variability
Individual vs. population
Business model
Results
Dissemination
32
33
Alan Williams (1927-2005)
Archie Cochrane (1909-1988)
J Epidemiol & Community Health 1997;51:116-20
Evidence based medicine in not enough
Costs represent health gains that have been denied to others.
All health care activities which meet certain minimum cost effectiveness requirements, when provided for certain specified categories of people, should be provided free within the NHS.
34
Lots of it, for a few Not much, to many
35
Value for money
JAMA. 2012;307(14):doi:10.1001/jama.2012.362
37
To conclude: How many "P" are necessary?
38
PredictivePreventivePersonalizedParticipatory
Population perspective
P4
P5
Policy Productivity Precision. People (groups of persons with common needs)Peculiarities Payment. Purpose. Poverty. Palliative Proximity Plurality PlanningProactivity…
P18 ?
39
Thank you very much for your attention!!!