Dr Ian Katz, Dermatopathologist, from Southern Sun Skin Cancer Clinic and Southern Sun Pathology, discusses the pro and cons of using shave biopsies in clinical skin cancer practice.
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1. Using shavebiopsies/excisions inpracticeDr Ian KatzDr Ian
Katz, Southern Sun Pathology
2. What is a shave? Superficial shave Approximately 1-2 mm
Heals really well generally Suacerization shave Deeper More risk of
scarringDr Ian Katz, Southern Sun Pathology
3. NHMRC guidelines for diagnosis ofmelanoma Chapter 6 Biopsy
1. The optimal biopsy approach is complete excision with a 2mm
margin andupper subcutis (Level C) 2. Partial biopsies may not be
fully representative of the lesion and need to beinterpreted in
light of the clinical findings (level C) 3. Incisional, punch or
shave biopsies may be appropriate in carefullyselected clinical
circumstances, for example, for large facial or acrallesions, or
where the suspicion of melanoma is low (level c) Good practice
point It is advisable to review unexpected pathology results with
the reportingpathologistDr Ian Katz, Southern Sun Pathology
4. Level C: Body of evidence provides some support for
recommendation(s) but careshould be taken in its applicationDr Ian
Katz, Southern Sun Pathology
5. Index of suspicion for melanoma Low ? Watch, annual review
High Prefer excision Medium Largest group Excision or shaveDr Ian
Katz, Southern Sun Pathology
6. Effect of biopsy type on outcomes inthe treatment of primary
cutaneousmelanoma Am J Surg. 2013 May;205(5):585-90. doi:
10.1016/j.amjsurg.2013.01.023. .Mills JK, White I, Diggs B, Fortino
J, Vetto JT. Source Department of Surgery, St. Vincents Hospital,
Melbourne, Victoria, Australia. Abstract BACKGROUND: Surgical
excision remains the primary and only potentially curative
treatment for melanoma. Although current guidelines recommend
excisional biopsy as the technique of choicefor evaluating lesions
suspected of being primary melanomas, other biopsy types are
commonly used. We sought to determine the impact of biopsy type
(excisional, shave, orpunch) on outcomes in melanoma. METHODS: A
prospectively collected, institutional review board-approved
database of primary clinically node-negative melanomas (stages
cT1-4N0) was reviewed to determine the impact ofbiopsy type on
T-staging accuracy, wide local excision (WLE) area (cm(2)),
sentinel lymph node biopsy (SLNB) identification rates and results,
tumor recurrence, and patientsurvival. RESULTS: Seven hundred nine
patients were diagnosed by punch biopsy (23%), shave biopsy (34%),
and excisional biopsy (43%). Shave biopsy results showed
significantly more positivedeep margins (P < .001). Both shave
and punch biopsy results showed more positive peripheral margins (P
< .001) and a higher risk of finding residual tumor (with
resulting tumorupstaging) in the WLE (P < .001), compared with
excisional biopsy. Punch biopsy resulted in a larger mean WLE area
compared with shave and excisional biopsies (P = .030), andthis
result was sustained on multivariate analysis. SLNB accuracy was
98.5% and was not affected by biopsy type. Similarly, biopsy type
did not confer survival advantage orimpact tumor recurrence; the
finding of residual tumor in the WLE impacted survival on
univariate but not multivariate analysis. CONCLUSIONS: Both shave
and punch biopsies demonstrated a significant risk of finding
residual tumor in the WLE, with pathologic upstaging of the WLE.
Punch biopsy also led to a larger meanWLE area compared with other
biopsy types. However, biopsy type did not impact SLNB accuracy or
results, tumor recurrence, or disease-specific survival (DSS).
Punch and shavebiopsies, when used appropriately, should not be
discouraged for the diagnosis of melanoma.Dr Ian Katz, Southern Sun
Pathology
7. Effect of biopsy type on outcomes inthe treatment of primary
cutaneousmelanoma RESULTS: Seven hundred nine patients were
diagnosed by punch biopsy (23%), shave biopsy(34%), and excisional
biopsy (43%). Shave biopsy results showed significantly more
positive deep margins (P < .001). Both shave and punch biopsy
results showed more positive peripheral margins (P < .001)and a
higher risk of finding residual tumor (with resulting tumor
upstaging) in the WLE (P< .001), compared with excisional
biopsy. Punch biopsy resulted in a larger mean WLE area compared
with shave and excisionalbiopsies (P = .030), and this result was
sustained on multivariate analysis. SLNB accuracy was 98.5% and was
not affected by biopsy type. Similarly, biopsy type did not confer
survival advantage or impact tumor recurrence; thefinding of
residual tumor in the WLE impacted survival on univariate but not
multivariateanalysis.Dr Ian Katz, Southern Sun Pathology
8. Effect of biopsy type on outcomes inthe treatment of primary
cutaneousmelanoma CONCLUSIONS: Both shave and punch biopsies
demonstrated a significant risk offinding residual tumor in the
WLE, with pathologic upstaging of theWLE. Punch biopsy also led to
a larger mean WLE area compared withother biopsy types. However,
biopsy type did not impact SLNB accuracy or results,
tumorrecurrence, or disease-specific survival (DSS). Punch and
shave biopsies, when used appropriately, should not bediscouraged
for the diagnosis of melanoma.Dr Ian Katz, Southern Sun
Pathology
9. Favorable long-term outcomes in patients with histologically
dysplastic nevi thatapproach a specimen border.J Am Acad Dermatol.
2013 Apr;68(4):545-51. doi: 10.1016/j.jaad.2012.09.031. Epub 2012
Nov 3.Hocker TL, Alikhan A, Comfere NI, Peters MS.SourceDepartment
of Dermatology, Mayo Clinic, Rochester, Minnesota55905,
USA.AbstractBACKGROUND:Patients with multiple clinically dysplastic
nevi are at increased risk for development of melanoma. However,
the risk of melanoma arising in a histologically dysplastic nevus
(HDN) is unknown.OBJECTIVE:We sought to determine the rate of
melanoma development in patients with HDNs that approached a
microscopic border but were not re-excised.METHODS:We performed a
retrospective study of patients evaluated in our dermatology
department from January 1, 1980, to December 31, 1989, who had a
HDN that extended to within 0.2 mm of a microscopic punch, shave,
orexcision border and was not re-excised.RESULTS:The average
follow-up in our cohort of 115 patients was 17.4 years (range:
0.0-29.9): 82 patients (71.3%) were followed up for longer than 10
years, 78 (67.8%) longer than 15 years, and 73 (63.4%) had more
than 20years of follow-up; 66 of 115 nevi were mildly dysplastic,
42 moderately dysplastic, and 7 had severe dysplasia. No patient
developed metastatic melanoma or melanoma at the site of removal of
a HDN.LIMITATIONS:This was a retrospective study performed at 1
large academic medical center.CONCLUSION:During a long-term
follow-up period, no patient developed melanoma at the site of an
incompletely or narrowly removed HDN, providing evidence that
routine re-excision of mildly or moderately dysplastic nevi may not
benecessary.Copyright 2012 American Academy of Dermatology, Inc.
Published by Mosby, Inc. All rights reserved.Dr Ian Katz, Southern
Sun Pathology
10. Favorable long-term outcomes in patients with
histologicallydysplastic nevi that approach a specimen
border.CONCLUSION:During a long-term follow-up period, no patient
developedmelanoma at the site of an incompletely or narrowly
removedHDN, providing evidence that routine re-excision of mildly
ormoderately dysplastic nevi may not be necessary.Dr Ian Katz,
Southern Sun Pathology
11. Shave biopsy is a safe and accuratemethod for the initial
evaluation ofmelanoma. J Am Coll Surg. 2011 Apr;212(4):454-60;
discussion 460-2. doi: 10.1016/j.jamcollsurg.2010.12.021. Zager JS,
Hochwald SN, Marzban SS, Francois R, Law KM, Davis AH, Messina JL,
Vincek V, Mitchell C, Church A, Copeland EM, Sondak VK, Grobmyer
SR. Source Department of Cutaneous Oncology, Moffitt Cancer Center,
and the University of South Florida College of Medicine, Tampa, FL
33612, USA. [email protected] Abstract BACKGROUND: Shave
biopsy of cutaneous lesions is simple, efficient, and commonly used
clinically. However, this technique has been criticized for its
potential to hamper accurate diagnosis andmicrostaging of melanoma,
thereby complicating treatment decision-making. STUDY DESIGN: We
retrospectively analyzed a consecutive series of patients referred
to the University of Florida Shands Cancer Center or to the Moffitt
Cancer Center for treatment of primarycutaneous melanoma, initially
diagnosed on shave biopsy to have Breslow depth < 2 mm, to
determine the accuracy of shave biopsy in T-staging and the
potential impact ondefinitive surgical treatment and outcomes.
RESULTS: Six hundred patients undergoing shave biopsy were
diagnosed with melanoma from extremity (42%), trunk (37%), and head
or neck (21%). Mean ( SEM) Breslow thickness was0.73 0.02 mm; 6.2%
of lesions were ulcerated. At the time of wide excision, residual
melanoma was found in 133 (22%), resulting in T-stage upstaging for
18 patients (3%).Recommendations for additional wide excision or
sentinel lymph node biopsy changed in 12 of 600 (2%) and 8 of 600
patients (1.3%), respectively. Locoregional recurrenceoccurred in
10 (1.7%) patients and distant recurrence in 4 (0.7%) patients.
CONCLUSIONS: These data challenge the surgical dogma that
full-thickness excisional biopsy of suspicious cutaneous lesions is
the only method that can lead to accurate diagnosis. Data
obtainedon shave biopsy of melanoma are reliable and accurate in
the overwhelming majority of cases (97%). The use of shave biopsy
does not complicate or compromise management ofthe overwhelming
majority of patients with malignant melanoma.Dr Ian Katz, Southern
Sun Pathology
12. Shave biopsy is a safe and accuratemethod for the initial
evaluation ofmelanoma RESULTS: Six hundred patients undergoing
shave biopsy were diagnosed withmelanoma from extremity (42%),
trunk (37%), and head or neck (21%).Mean ( SEM) Breslow thickness
was 0.73 0.02 mm; 6.2% of lesions wereulcerated. At the time of
wide excision, residual melanoma was found in 133 (22%), resulting
in T-stage upstaging for 18 patients (3%). Recommendations for
additional wide excision or sentinel lymph nodebiopsy changed in 12
of 600 (2%) and 8 of 600 patients (1.3%), respectively.Locoregional
recurrence occurred in 10 (1.7%) patients and distantrecurrence in
4 (0.7%) patients.Dr Ian Katz, Southern Sun Pathology
13. Shave biopsy is a safe and accuratemethod for the initial
evaluation ofmelanoma CONCLUSIONS: These data challenge the
surgical dogma that full-thickness excisionalbiopsy of suspicious
cutaneous lesions is the only method that canlead to accurate
diagnosis. Data obtained on shave biopsy of melanoma are reliable
and accuratein the overwhelming majority of cases (97%). The use of
shave biopsy does not complicate or compromisemanagement of the
overwhelming majority of patients withmalignant melanomaDr Ian
Katz, Southern Sun Pathology
14. My rules for dealing with atypicalmelanocytic lesions on
shavesMildly atypical andpatient happy andwilling to watchWatchDr
Ian Katz, Southern Sun Pathology
15. My rules for dealing with atypicalmelanocytic lesionsMildly
atypicaland patient giveshistory of changeExciseDr Ian Katz,
Southern Sun Pathology
16. My rules for dealing with atypicalmelanocytic lesionsMod or
severelyatypicalExciseDr Ian Katz, Southern Sun Pathology
17. My rules for dealing with atypicalmelanocytic
lesionsAtypical lesionon markedly sun-damaged skinExciseDr Ian
Katz, Southern Sun Pathology
18. Margins with shaves A lottery Depends on orientationDr Ian
Katz, Southern Sun Pathology
19. Dr Ian Katz, Southern Sun Pathology
20. Dr Ian Katz, Southern Sun Pathology
21. Dr Ian Katz, Southern Sun Pathology
22. When shaves arrive in the lab Generally are shrivelled and
folded due to formalin Sectioning is in a random plane Examining
and reporting on what is seen on the surface when cutting-up if
difficultDr Ian Katz, Southern Sun Pathology
23. The plane of section determines which margins are
examined.Dr Ian Katz, Southern Sun Pathology
24. Dr Ian Katz, Southern Sun Pathology
25. The lesion is clear of marginsIn the plane of
sectionsPigmented lesion on surfaceDistance clear Distance clearDr
Ian Katz, Southern Sun Pathology
26. Dr Ian Katz, Southern Sun Pathology
27. Pigmented lesion on surfaceMargins are involved in the
planeof sectionsDr Ian Katz, Southern Sun Pathology
28. Random plane of section Can be any one of 360 degrees May
or may not include involved margin Pure luckDr Ian Katz, Southern
Sun Pathology
29. Positive margins Positive margins in shave mean positive
Negative margins mean nothing could still be positiveDr Ian Katz,
Southern Sun Pathology