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Presentation by Sijme Zeilemaker of ToBBB for the Science meets Business café of 12 sep 2013. This event was held in the BioPartner Accelerator building in Leiden.
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Safely Enhancing Drug Delivery to the CNS
An Innovative Platform Technology
Sijme Zeilemaker, MScBusiness Development Associateto-BBB
Science meets BusinessSeptember 2013
Background
2005 – 2011 Biomedical Sciences at Leiden University
2008: LACDR internship
Master Biomedical Sciences – Management
Science Based Business
2010: Business Internship
A start-up company in neuroscience…
Blood-Brain Barrier
600 kilometer
Every neuron has its own capillary
• G-Technology®: safe brain delivery technology• Glutathione: safe brain targeting mechanism • PEG-liposomes: well-established delivery technology• Strong patent protection on any drug combination
to-BBB’s brain drug delivery platform
G-Technology: mechanistic validation in vitro
5 times more in brain improved anti-cancer effect
G-Technology: mechanistic validation in vivo
Doxil/Caelyx: PEG liposomal doxorubicin2B3-101: Glutathione-PEG liposomal doxorubicin
2B3-101: confirming the safe brain delivery platform
Lead product 2B3-101 treating patients with brain cancer•Therapeutic dosages reached with a predictable safety profile
•Favorable long circulation plasma half-life of 64 hours
•Early signs of clinical efficacy with partial responses and stable disease
•Results to be presented at European Cancer Congress, Amsterdam
2-fold business model: internal development
Enhanced uptake across CNS•Safe, endogenous mechanism
Increased half life•Reduce dosing frequency
Liposomal shielding•Reduce side effects
Strong IP protection•Life Cycle Management
2-fold business model: pharma/biotech partnering
this could be your compound!
Business Development: all about partnering
Pharma*:
Mid-size pharma / biotech*:
Grants:
*examples
Business Development: getting done more… with less
Pharma*:
Mid-size pharma / biotech*:
Grants:
*examples
build a leading company in brain drug development
build a leading company in brain drug development