A PRESENTATION ON ROLE OF OXIDATIVESTRESS IN DISEASE MODIFICATION

Presented By : Soobiya Majeed

Roll No. 14451S0110 M.Pharm (sem-I)

Pharmacology SUCP

Under the guidance of:Dr. Anupama KoneruM.pharm, ph.DPrincipalSUCP

CONTENTS

1. INTRODUCTION

2. OXIDATIVE STRESS

3. FACTORS AFFECTING OXIDATIVE STRESS

4.FREE RADICALS

5.OXIDATIVE STRESS AND DISEASES

6. CONCLUSION

7. BIBLIOGRAPHY

OXIDATIVE STRESS

Oxidative stress reflects an imbalance between the systemic manifestation of reactive oxygen

species and a biological system's ability to readily detoxify the reactive intermediates or to

repair the resulting damage.

What are free radicals?

Reactive oxygen species

Free radicals acumulate

damageCELLS

DNALIPIDS SUGARS

PROTEINS

CELL MEMBRANE DYSFUNCTION

DNA DAMAGE

ENZYMEREACTIVATION

PROTEIN RE-MODIFICATION

AGING DISEASES

OXIDATIVE STRESS AND DISEASES

OXIDATIVE STRESS AND PARKINSONS DISEASE

lAt the cellular level, PD is related to excess production of reactive oxygen species (ROS), lto alterations in catecholamine metabolism, to modifications in mitochondrial electron transporter lChain (METC) function or to enhancement of iron deposition in the SNpc.

OXIDATIVE STRESS AND CANCER

OXIDATIVE STRESS AND CARDIAC FAILURE

ANTIOXIDANTS

VITAMIN EVITAMIN C

FLAVANOIDSCHLOROPHYLLCAROTENIODS

DISEASES

ANTI OXIDANTS

1.PREVENTION

2.INTERCEPTION

3.REPAIR

STOP PRODUCTION

COLLECT UNSAFE SPECIES

CONVERT TO SAFER SPECIES

FREE RADICALS

CONCLUSIONOxidative stress is considered as the major underlying cause of various diseases. It is found that generation of reactive metabolits play a central role in cell’s life. These metaboloites are continuously controlled by endogenous antioxidant enzyme system, which may be enzymatic or non-enzymatic or transitional metals. Thus, the balance is created between pro-oxidants and antioxidants. Reactivemetabolites play important biological functions in calls in a controlled environment. The impairment of antioxidant status, either by exogenous or endogenous sources, may disturb the cellular redox balance and the pathological condition would be the main characteristics and forms oxidative stress in cells and tissues. There by leading to various diseases.

BIBLIOGRAPHY

1.Basic and Clinical Pharmacology 12/E (Lange Basic Science)

2.Rang & Dale's pharmacology, 8th edition from Humprey Rang.

3.Essentials of medical pharmacology(jaypee) k.d. Tripathi

4.Martinez-Vicente M, Talloczy Z, Kaushik S, Massey AC, Mazzulli J, Mosharov EV,

Hodara R, Fredenburg R, Wu DC, Follenzi A, Dauer W, Przedborski S,

I schiropoulos H, Lansbury PT, Sulzer D,Cuervo AM. Dopamine-modified

alpha-synuclein Blocks chaperone-mediated autophagy.

5.J Clin Invest. 2008;118:777–788.

6. Lotharius J, Brundin P. Impaired dopamine storage resulting from

alpha-synuclein mutations may contribute to the pathogenesis of Parkinson's disease.