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THERAPY SOLO CAT
HAMAD emad thuhayr
CONTENT
• WHAT QUESTION DID THE STUDY ASK?
• ARE THE RESULTS OF THE STUDY VALID (STEP 1)
• WHAT WERE THE RESULTS (STEP 2)
• APPLICABILITY OF THE RESULTS ( STEP 3)
WHAT QUESTION DID THE STUDY ASK?
CATEGORY ANSWER
POPULATION Children ( 2-6 years) with respiratory illnesses
INTERVENTION Using normal milk containing probiotic lactobacillus rhamnosus GG
COMPARISON Normal milk only
OUTCOME Primary : measure the respiratory symptoms improvement by using probiotic GG milk
Secondary: measure the gastrointestinal symptoms improvement by using probiotic GG milk
ARE THE RESULTS OF THE STUDY VALID
Was the assignment of patients to treatment randomized?
ARE THE RESULTS OF THE STUDY VALID
Was the randomization list concealed?
ARE THE RESULTS OF THE STUDY VALID
Was follow-up of patients sufficiently long and complete?
ARE THE RESULTS OF THE STUDY VALID
Were patients analyzed in the groups which they were randomized?
ARE THE RESULTS OF THE STUDY VALID
Were patients and clinician kept ‘blind’ to treatment?
yes, blinding both the clinician and children *parent* to the treatment.
ARE THE RESULTS OF THE STUDY VALID
Were the groups treated equally, apart from the experimental treatment?
ARE THE RESULTS OF THE STUDY VALID
Were the groups similar at the start of the trial?
ARE THE VALID RESULTS OF THIS RCT IMPORTANT?
What is the magnitude of the treatment effect?
Odd Ratio REGARDING TO PRIMARY OUTCOME ( RESPIRATORY SYMPTOMS )
GG group
OR of 5.03(95% CI 4.92-5.15 )
Placebo group OR of 5.17(95% CI 5.05-5.29)
ARE THE VALID RESULTS OF THIS RCT IMPORTANT?
How precise is this estimate of the treatment effect?
Odd Ratio REGARDING TO PRIMARY OUTCOME ( RESPIRATORY SYMPTOMS )
GG group
OR of 5.03(95% CI 4.92-5.15 )
Significant and precise
Placebo group OR of 5.17(95% CI 5.05-5.29)
Significant and precise
ARE THESE VALID, IMPORTANT RESULTS
APPLICABLE TO MY PATIENTS?
Is our patient so different from those in the study that its results cannot apply ?The patients in the study are similar to our patients, mainly similar Demographic and clinical characteristics ( which the author provides)
So, we can apply the results in our setting
Is the treatment feasible in my setting ?
Milk containing probiotic Lactobacillus rhamnosus GG is available in our market
0000000
ARE THESE VALID, IMPORTANT RESULTS
APPLICABLE TO MY PATIENTS?
What are our patient’s potential benefits and harms form the therapy ?
Benefits
0
Harms
0
ARE THESE VALID, IMPORTANT RESULTS
APPLICABLE TO MY PATIENTS?
What are our patients values and expectations for both the outcome we are trying to prevent and the treatment that we are offering ?
Decrease respiratory symptoms as a primary outcome of the study, also decrease gastrointestinal symptoms
Find an alternative method to decrease the illness with effectively with less side effects and easy administration not like the chemical drugs
ARE THESE VALID, IMPORTANT RESULTS
APPLICABLE TO MY PATIENTS?