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By the Name of Allah, The Most Gracious, The Most Merciful
Hereditary spherocytosis blood smear.
Sphere shape allow a much smaller surface area to volume ratio than biconcave shape
Scanning electron micrograph of a normal biconcave erythrocyte
Scanning electron micrograph of a spherocyte. The spherocyte is smaller, round, and lacks concavities
Sickle RBCs
A.Peripheral blood smear from a patient with sickle cell anemia.showing sickle cells, anisocytosis, poikilocytosis, & target cells .B , Higher magnification shows an
irreversibly sickled cell
Target cells
Target cells(arrows) anisocytosis poikilocytosis.
Peripheral blood smear (Heinz bodies) revealed by supravital staining.
"bite cells".
PCV
Polycythemia –blood film
PCV-bone marrow
ALL-Lymphoblasts have fewer nucleoli than do myeloblasts, and the nuclear chromatin is more condensed.
Cytoplasmic granules are absent
AML-Myeloblasts have delicate nuclear chromatin, prominent nucleoli, and
fine azurophilic granules in the cytoplasm (arrows).
Acute lymphoblastic leukemia (ALL) blood smear.
ALL-L3
ALL- bone marrow aspirate.
AML-Auer rods
AML-bone marrow
Acute promyelocytic leukemia (FAB AML-M3) blood smear. Note the
cytoplasmic granules in the cell at the top and the multiple Auer rods in the cell at the bottom.
AML-M3 bone marrow
CML-Peripheral blood smear shows many mature neutrophils, some
metamyelocytes, and a myelocyte and a myeloblast.
CLL-blood smear Lymphocytosis of small mature-appearing lymphocytes. Numerous “smudge” cells are present.
. CLL
Condensed “soccer ball” nuclear chromatin; one “smudge cell” is present.
Diffuse large B-cell lymphoma, medium power.
Diffuse large B-cell lymphoma, high power.
Diffuse large B-cell lymphoma, high power.
Follicular lymphoma
Follicular lymphoma
Small Lymphocytic Lymphoma
MALT lymphoma
Burkitt’s Lymphoma “starry sky” appearance.
Hodgkin’s lymphoma RS cell
Hodgkin disease, lymphocyte-predominance type. Numerous mature-looking lymphocytes surround scattered, large, pale-staining lymphocytic
and histiocytic variants ("popcorn" cells).
Hodgkin lymphoma, nodular sclerosis type. A low-power view shows well-defined
bands of pink, acellular collagen that have subdivided the tumor cells into nodules
Hodgkin lymphoma, nodular sclerosis type. A distinctive "lacunar cell" with multilobed nucleus containing many small nucleoli is seen lying within a clear space created by retraction of its
cytoplasm. It is surrounded by lymphocytes.
Hodgkin disease, mixed-cellularity type. A diagnostic, binucleate Reed-Sternberg cell is surrounded by multiple cell types, including eosinophils (bright-red cytoplasm), lymphocytes,
and histiocytes.
Multiple Myeloma
Multiple myeloma blood smear. Rouleaux formation.
Multiple myeloma bone marrow aspirate. Numerous plasma cells, many of
which have prominent nucleoli (normal plasma cells lack nucleoli), are present