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HINRI Labs © 2009
Healthcare Institute for Neuro-Recovery and Innovation
“Turning knowledge into practice to transform lives.”
Translational
Translational Labs
A patient-centered approach to:
“Turning knowledge into practice to transform lives.”
HINRI Labs © 2009
HINRI Translational Labs Mission
Build a nationally recognized nexus for academia, science, medicine, business, philanthropy, and public policy to advance patient-centered
research, rehabilitation, restoration, and recovery from neurological impairments due to
injury, disease, or congenital causes.
HINRI Labs © 2009
HINRI Labs © 2008
HINRI Translational Labs Goals
• Turn knowledge into practice to transform lives by:– Creating the nation's leading translational laboratories for
spinal cord injury, brain trauma, and neurological disorders with collaboration centers in Atlanta, Palo Alto, and Boston
– Linking knowledge, ideas, and innovation from the scientific, medical, philanthropic, public policy, investment, and patient communities
• Create and support clinical trials to speed times between innovation and application: – Supporting translational and clinical research – Promoting promising new technologies and commercial
applications
HINRI Translational Labs Goals (cont.)
• Develop patient-centric coordinated care models:– Collaborate with experts on clinical, physical, emotional,
lifestyle, financial, family, friends, community, and faith for optimum capabilities development
• Engage Venture Philanthropy, Foundations, & Payors: – Fostering a pre-competitive environment to evaluate and
distribute critical intellectual property from research – Establishing best practices and a model standard of care for
rehabilitation and restoration– Creating economic support and rationalization of care for
recovery HINRI Labs © 2008
HINRI Labs © 2008
HINRI Translational Lab The Problem Statement
Institute of Medicine – “it takes 18 years for accepted research to become common practice”, because of:
• Inadequately focused research • Delays in research to trials• Delays in trials to specialist providers• Delays in specialist knowledge to common practice • Delays in treatment applications to help patients• Lack of patient-centered treatments – traditional focus is on
incomplete SCI rather than acute (1st 30 days) or complete SCI • Reimbursement and Treatment Limits
HINRI Labs © 2008
HINRI Translational Lab The Solution
Rapid Dissemination and Translation of Ideas & Best Practices for:
• Research – coordinate and support new ideas• Rehabilitation – Test and develop new individualized
patient-centered physical and emotional approaches to rehabilitation
• Restoration – Promote and conduct clinical trial testing in partnership with researchers, early stage companies and trauma centers
• Recovery – Provide clinical, emotional, & lifestyle education for individual, family, and friends to optimize recovery and capabilities
Translational Research
HINRI Labs © 2008
Atlanta*
Boston*Palo
Alto*HINRI LABS
Finding Patient Centered Solutions
RestorationRehabilitation
Recovery
* Academia, Science, Medicine, Business, Philanthropy, and
Public Policy
Translational Rehabilitation
HINRI Labs HINRI Labs HINRI Labs
Activity-Based
Electrophysiology
Patients
Payors
Nutrition/Supplements
Mental, SpiritualEmotional Health
Locomat & Armin
Tissue Regeneration
Manual TherapyMedical
Monitoring
Patient Centered
Best Practices
Improved Functionality
Optimum Capabilities
Hyperbaric Chamber
Collaboration Traditional RehabNon-Traditional Rehab
Assistive Technology
Clinical Trials
Clinical Practice
Academia, Business
HINRI Labs © 2008
Translational Restoration
HINRI Labs © 2008
Basic Research
“P of P” Research
Clinical Research
Clinical Practice
University Partners
HINRI Labs
Shepherd Center
Trauma Centers
“Proof of Principle” Research – Does the basic science & new ideas hold true for human patients?
HINRI Translational Lab’s patient-centered clinical trial platform will foster collaboration between
universities and clinical research centers.
Translational Recovery
HINRI Labs © 2008
Medication
Therapy
Physical Health
NutritionSocialization
Readiness for Employment
Education
Spirituality
Leisure Activities
Family and Friends
Patient CenteredGoals
Normality
Functionality
Fulfillment
Independence
HINRI Labs © 2008
Hinri LABS Areas of Focus
Permanent or irreversible
central nervous system disorders
• Phase 1 - “Complete” Spinal Cord Injury (SCI)
• Phase 2 - Traumatic Brain Injury (TBI) and Stroke
• Phase 3 - Neurological Disorders*
*Disease/Degeneration – Multiple Sclerosis, Amyotrophic Lateral Sclerosis, Parkinson’s, and Alzheimer’s
HINRI Labs – Action Plan
1A Complete SCI Measurement – Neural Plasticity, Functional
Recovery
Electrophysiology and Robotics
1B Complete SCI Translation – Bench to Bedside
Assistive Technology, Holistic Medicine, Stem Cell Research
2 Brain Injury Measurement and Translation
Imaging, Surgery, Pharmaceuticals, Stem
Cells, Emerging Therapies
3 Neuro-Disease
Neural Injury and Degeneration - Cell
death, nerve regeneration and reconnection
Basic Research
Phase Target Focus Method
HINRI Labs © 2008
HINRI Labs Timeline 2009
JAN FEB MAR APR MAY JUN JUL AUG SEP OCT NOV DEC
Atlanta – 1A
($3 MM)
Atlanta – 1B
($5 MM)
Palo Alto – 1A*
($10 MM)
Boston – 1A
($2.5 MM)
Atlanta – 2
($7.5 MM)
Atlanta – 3
($5 MM)
Phase
HINRI Labs © 2008*10 MM to be raised for Dr. Gary Steinberg and Dr. Graham Creasey at Stanford
US Military Wounded Veterans
Patients
Test & DevelopBest Practices
Rehabilitation
Business Model
Promote/Conduct Clinical Trials
Restoration
Collaborate onBest Practices
Rehabilitation
Patient Centered Clinical & Lifestyle
Recovery
Foundations & CharitiesCommon Mission
Collaborate onBest Practices
Rehabilitation
Government, VA, Private Insurance
Capital
Venture PhilanthropyCommon Goals
Coordinate & Support Research
Strategic PartnersCollaboration
Translational
Strategic Partners
• Location – The Shepherd Center has agreed to provide space on the third floor in their main building
• University Partners - Emory, Stanford and Harvard/MIT
• Media – CNN (Dr. Sanjay Gupta)• Corporate - Google Health and Microsoft HealthVault• SHARE Initiative – a $6MM partnership between
Humana, Major League Baseball, Bernie Marcus and the McCormick Foundation to assist Wounded Veterans and their Families at Shepherd (100 participants to date)
Venture Philanthropy
Corporate Partners• Dr. Louis Sullivan* – 3M; Bristol, Myers, Squibb; CIGNA• Bernie Marcus – SHARE Initiative, Home Depot ($300 MM)• Jeff Arnold – WebMD• Bill Ide – Former ABA President, East West Institute• Bob Bozeman – Google Health• Ron Bachman - Microsoft HealthVault• John Brandon – Apple • John Moore – Morgan Stanley (Former Head of Global HC)• Carter Burton – GE Healthcare Financial Services• Sanjay Gupta – CNN Medical Director• Steve Case – Former Vice-Chair CECP• Anthony Begando – Tenon Consulting
* Have agreed to collaborate
Foundations & CharitiesInitial Prospect List
Foundation Partners:
• Woodruff• Hewlett• Bill/Melinda Gates • Omidyar Network • Google• Gordon Moore• Henry Kravitz
Advisory Panel:
•David Brailer – Health Evolution Partners•Kleiner Perkins - Brooke Buyers •Draper Fisher Jurvetson - Steve Jurvetson and Tim Draper•James Robinson III – RRE Ventures•Pete G. Peterson – Blackstone•Silicon Valley Bank – Carlyle Group•Bono – Elevation Partners
Military Partners• Armed Forces Service Organization (AFSO)• United Service Organization (USO)• Wounded Warrior Project • Military Foundations (2) – Tenon Consulting Solutions
Advisory Panel• Hon. Max Cleland• Hon. John McCain (Orson Swindle)• Gen. Norman Schwarzkopf• Hon. Jeb Bush and/or Hon. Jay Rockefeller• Tom Hanks – www.welcomebackveterans.org • Robin Williams - Christopher and Dana Reeve Foundation• Congressional Service Academy Representatives• Former Head(s) of VA or VA Hospital System• Secretary of the Army and/or Joint Chiefs
US MilitaryInitial Prospect List
HINRI Labs © 2008
CHT Partnership
A CHT “Capabilities” Project
– Ross Mason, Fellow CHT
The Center for Health Transformation (CHT) will partner with HINRI Translational Labs (Atlanta, Palo Alto, and Boston) to advise, support, and promote the creation of a national nexus, collaboration, and model of a patient-centered standard of care in research, rehabilitation, restoration, and recovery from “permanent” central nervous system disorders.