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8/14/2019 Explanation of HINRI Labs
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8/14/2019 Explanation of HINRI Labs
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Translational Labs
A patient-centered approach to:
Turning knowledge into practice totransform lives.
HINRI Labs 2008
8/14/2019 Explanation of HINRI Labs
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HINRI Translational LabsMission
Build a nationally recognized nexusfor academia, science, medicine,
business, philanthropy, and publicpolicy to advance patient-centered
research, rehabilitation,
restoration, and recovery fromneurological impairments due toinjury, disease, or congenital causes.
HINRI Labs 2008
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HINRI Labs 2008
HINRI Translational Labs Goals
Turn knowledge into practice to transform lives by: Creating the nation's leading translational laboratories for
spinal cord injury, brain trauma, and neurological disorderswith collaboration centers in Atlanta, Palo Alto, and Boston
Linking knowledge, ideas, and innovation from thescientific, medical, philanthropic, public policy, investment,and patient communities
Create and support clinical trials to speed timesbetween innovation and application: Supporting translational and clinical research Promoting promising new technologies and commercial
applications
8/14/2019 Explanation of HINRI Labs
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HINRI Translational Labs Goals(cont.)
Develop patient-centric coordinated care models: Collaborate with experts on clinical, physical, emotional,
lifestyle, financial, family, friends, community, and faith
for optimum capabilities development
Engage Venture Philanthropy, Foundations, & Payors:
Fostering a pre-competitive environment to evaluate anddistribute critical intellectual property from research
Establishing best practices and a model standard of care forrehabilitation and restoration
Creating economic support and rationalization of care forrecovery
HINRI Labs 2008
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HINRI Labs 2008
HINRI Translational LabThe Problem Statement
Institute of Medicine it takes 18 years for acceptedresearch to become common practice, because of:
Inadequately focused research
Delays in research to trials Delays in trials to specialist providers
Delays in specialist knowledge to common practice
Delays in treatment applications to help patients
Lack of patient-centered treatments traditional focus is onincomplete SCI rather than acute (1st 30 days) or complete SCI
Reimbursement and Treatment Limits
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HINRI Labs 2008
HINRI Translational Lab The Solution
Rapid Dissemination and Translation of Ideas &Best Practices for:
Research coordinate and support new ideas Rehabilitation Test and develop new individualized
patient-centered physical and emotional approaches torehabilitation
Restoration Promote and conduct clinical trial testing inpartnership with researchers, early stage companies andtrauma centers
Recovery Provide clinical, emotional, & lifestyleeducation for individual, family, and friends to optimizerecovery and capabilities
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Translational Research
HINRI Labs 2008
Atlanta*
Boston*Palo
Alto*HINRILABS
Finding Patient Centered Solutions
RestorationRehabilitation
Recovery
* Academia, Science,
Medicine, Business,
Philanthropy, and
Public Policy
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Translational Rehabilitation
HINRI Labs HINRI Labs HINRI Labs
Activity-Based
Electrophysiology
Patients
Payors
Nutrition/Supplements
Mental, Spiritual
Emotional Health
Locomat &
Armin
Manual Therapies
Massage TriggerMedical
Monitoring
PatientCentered
Best Practices
Improved
FunctionalityOptimum
Capabilities
Hyperbaric
Chamber
Collaboration Traditional RehabNon-Traditional Rehab
Assistive
Technology
Clinical Trials
Clinical Practice
Academia,
Business
HINRI Labs 2008
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Translational Restoration
HINRI Labs 2008
Basic
Research
P of P
Research
Clinical
Research
Clinical
Practice
University
Partners
HINRI
Labs
Shepherd
Center
Trauma
Centers
Proof of Principle Research Does the basic science &
new ideas hold true for human patients?
HINRI Translational Labs patient-centered clinical
trial platform will foster collaboration between
universities and clinical research centers.
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Translational Recovery
HINRI Labs 2008
Medication
Therapy
Physical
Health
NutritionSocialization
Readiness for
Employment
Education
Spirituality
Leisure
Activities
Family and
FriendsPatient Centered
Goals
Normality
Functionality
Fulfillment
Independence
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HINRI Labs 2008
Hinri LABSAreas of Focus
Permanent or irreversible
central nervous system disorders
Phase 1 - Complete Spinal Cord Injury (SCI)
Phase 2 - Traumatic Brain Injury (TBI) and Stroke
Phase 3 - Neurological Disorders*
*Disease/Degeneration Multiple Sclerosis, Amyotrophic
Lateral Sclerosis, Parkinsons, and Alzheimers
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HINRI Labs Action Plan
1A Complete SCI Measurement NeuralPlasticity, Functional
Recovery
Electrophysiology and
Robotics
1B Complete SCI Translation Bench toBedside Assistive Technology,Holistic Medicine,Stem Cell Research
2 Brain Injury Measurement andTranslation
Imaging, Surgery,
Pharmaceuticals, Stem
Cells, EmergingTherapies
3 Neuro-
Disease
Neural Injury and
Degeneration - Cell
death, nerve regeneration
and reconnection
Basic Research
Phase Target Focus Method
HINRI Labs 2008
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HINRI Labs Rehabilitation Phase1A and 1B
Provide the scientific insights, new technologies and novel treatments to test, train and measurefunctional recovery (neural activity, muscle pattern activity, spinal reflexes and plasticity) Activity-Based Rehabilitation New Drugs, Electrical Stimulation and Cell Transplantation Therapies Train Reaching and Grasping (to improve upper extremity function)
Electrophysiology and Robotics (Lokomat and Armin) Control experimental conditions Generate standardized training of motor tasks Measure mechanical aspects of functional recovery
Proof of Principle Studies
Focus on underserved areas of investigation in SCI research Translate animal studies research to human SCI studies Neural mechanisms underlying functional recovery and neural connections across the level of injury Measure Brain Motor Control Assay (BMCA) Functional MRI and diffusion tensor imaging
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HINRI Labs Timeline 2009
JAN FEB MAR APR MAY JUN JUL AUG SEP OCT NOV DEC
Atlanta 1A
($3 MM)
Atlanta 1B
($5 MM)Palo Alto 1A
($2.5 MM)
Boston 1A
($2.5 MM)
Atlanta 2
($7.5 MM)
Atlanta 3
($5 MM)
Phase
HINRI Labs 2008
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US Military
Wounded Veterans
Patients
Test & Develop
Best Practices
Rehabilitation
Business Model
Promote/Conduct
Clinical Trials
Restoration
Collaborate on
Best Practices
Rehabilitation
Patient Centered
Clinical & Lifestyle
Recovery
Foundations & Charities
Common Mission
Collaborate on
Best Practices
Rehabilitation
Government, VA,
Private Insurance
Capital
Venture Philanthropy
Common Goals
Coordinate & Support
ResearchStrategic Partners
Collaboration
Translational
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Strategic Partners
Location The Shepherd Center has agreed to providethe third floor in their main building for HINRI Labs
University Partners - Emory, Georgia Tech and
Morehouse; Stanford and Harvard/MIT Media CNN (Dr. Sanjay Gupta)
Corporate - Google Health and Microsoft HealthVault
SHARE Initiative a $6MM partnership between
Humana, Major League Baseball, Bernie Marcus andthe McCormick Foundation to assist Wounded Veteransand their Families at Shepherd (68 participants to date)
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Venture Philanthropy
Corporate Partners Dr. Louis Sullivan* 3M; Bristol, Myers, Squibb; CIGNA Bernie Marcus SHARE Initiative, Home Depot ($300 MM) Jeff Arnold WebMD
Bill Ide Former ABA President, East West Institute Bob Bozeman Google Health Ron Bachman - Microsoft HealthVault John Brandon Apple John Moore Morgan Stanley (Former Head of Global HC)
Carter Burton GE Healthcare Financial Services Sanjay Gupta CNN Medical Director Steve Case Former Vice-Chair CECP Anthony Begando Tenon Consulting
* Have agreed to collaborate
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Foundations & CharitiesInitial Prospect List
Foundation Partners:
Woodruff
Hewlett Healthcare Georgia Bill/Melinda Gates Omidyar Network Google
Gordon Moore Henry Kravitz
Advisory Panel:
David Brailer Health Evolution Partners
Kleiner PerkinsDraper Fisher JurvetsonJames Robinson III RRE VenturesPete G. Peterson BlackstoneSilicon Valley Bank Carlyle GroupBono Elevation Partners
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Military Partners Armed Forces Service Organization (AFSO) United Service Organization (USO) Wounded Warrior Project Military Foundations (2) Tenon Consulting Solutions
Advisory Panel Hon. Sam Nunn and/or Max Cleland Hon. John McCain (Orson Swindle) Gen. Norman Schwartzkopf Hon. Jeb Bush and/or Hon. Jay Rockefeller Tom Hanks www.welcomebackveterans.org Congressional Service Academy Representatives Former Head(s) of VA or VA Hospital System Secretary of the Army and/or Joint Chiefs
US MilitaryInitial Prospect List
http://www.welcomebackveterans.org/http://www.welcomebackveterans.org/http://www.welcomebackveterans.org/http://www.welcomebackveterans.org/8/14/2019 Explanation of HINRI Labs
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HINRI Labs 2008
CHT Partnership
A CHT Capabilities Project
Ross Mason, Fellow CHT
The Center for Health Transformation (CHT) willpartner with HINRI Translational Labs (Atlanta, Palo
Alto, and Boston) to advise, support, and promote the
creation of a national nexus, collaboration, and model
of a patient-centered standard of care in research,rehabilitation, restoration, and recovery from
permanent central nervous system disorders.