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Dmitri Popov PhD Radiobiology
MD (Russia)
Advanced Medical Technology and
Systems Inc Canada
Slava Maliev PhD Radiobiology
Academy of Science Russia
Hadrons Radiation Protection
Hadrons Radiation Protection
Antiradiation vaccine Technology and
development of prophylaxis prevention and
treatment of biological consequences from
Heavy Ion irradiation
Hadrons
Hadrons are subatomic particles that can take
part in the strong interaction ndash the force that binds
protons inside the nuclei of atoms Physicists
have theorized since the 1960s and ample
experimental evidence since has confirmed
that hadrons are made up of quarks and
antiquarks that determine their properties Apr 9
2014
CERN
Hadrons
Hadrons are categorized into two
families baryons (such as protons and neutrons
made of three quarks) and mesons (such
as pions made of one quark and one antiquark)
A tetraquark state (an exotic meson) named
the Z(4430)minus was discovered in 2014 by
the LHCb collaboration
Hadrons
According to the quark model the properties of
hadrons are primarily determined by their so-
called valence quarks For example a proton is
composed of two up quarks (each with electric
charge +2frasl3 for a total of +4frasl3 together) and
one down quark (with electric charge minus1frasl3) Adding
these together yields the proton charge of +1
httpenwikipediaorgwikiHadron
Hadrons Medical Therapy
Radiation therapy is the medical use of ionizing
radiation to treat cancer In conventional radiation
therapy beams of X rays (high energy photons)
are produced by accelerated electrons and then
delivered to the patient to destroy tumour cells
Using crossing beams from many angles
radiation oncologists irradiate the tumour target
while trying to spare the surrounding normal
tissues Inevitably some radiation dose is always
deposited in the healthy tissues
httpenlightwebcernchwhat-is-hadron-therapy
Hadrons Heavy charged particles produce biological damage that is
different from that normally produced by sparsely ionizing radiation such as x- or gamma-rays DNA lesions are exquisitely complex and difficult to repair Relative biological effectiveness (RBE) factors are normally used to scale from x-rays to heavy ion damage but it should be kept in mind that RBE depends on several factors (dose dose rate endpoint particle energy and charge etc) and sometimes heavy ions produce special damages that just cannot be scaled by x-ray damage alone These special characteristics of heavy ions can be used to treat tumors efficiently as it is currently done in Japan and Germany but they represent a threat for human space exploration Health Phys 2012 Nov103(5)532-9 doi 101097HP0b013e318264b4b6
Eighth Warren K Sinclair keynote address Heavy ions in therapy and space benefits and risks
Durante M
Hadrons
When the irradiating beams are made of charged
particles (protons and other ions such as
carbon) radiation therapy is called hadron-
therapy The strength of hadron-therapy lies in the
unique physical and radiobiological properties of
these particles they can penetrate the tissues
with little diffusion and deposit the maximum
energy just before stopping
httpenlightwebcernchwhat-is-hadron-therapy
Hadrons Space Radiation Life Sci Space Res 197513187-93
Peculiarities of biological action of hadrons of space radiation
Akoev IG1 Yurov SS
Biological investigations in space enable one to make a significant contribution on high-energy hadrons to biological effects under the influence of factors of space flights Physical and molecular principles of the action of high-energy hadrons are analysed Genetic and somatic hadron effects produced by the secondary radiation from 70 GeV protons have been studied experimentally The high biological effectiveness of hadrons great variability in biological effects and specifically of their action are associated with strong interactions of high-energy hadrons These are the probability of nuclear interaction with any atom nucleus generation of a great number of secondary particles (among them probably highly effective multicharged and heavy nuclei antiprotons pi(-)-mesons) and the spatial distribution of secondary particles as a narrow cone with extremely high density of particles in its first part The secondary radiation generated by high- and superhigh-energy hadrons upon their interaction with the spaceship is likely to be the greatest hazard of radiation to the crew during space flights
Hadrons Radiation Protection Introduction An anti-radiation vaccine could be an
important part of a countermeasures reg-imen for effective radioprotection immunoprophylaxis and immunotherapy of the acute radi-ation syndromes (ARS) after gamma-irradiation neutron irradiation or heavy ion irradiation Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Reliable protection of non-neoplastic regions of patients with
different forms of cancer which undergo to heavy ion therapy (
eg Hadron-therapy) can significantly extend the efficiency of the
therapeutic course The protection of cosmonauts astronauts
from the heavy ion radiation component of space radiation with
specific immunoprophylaxis by the anti-radiation vaccine may be
an important part of medical management for long term space
missions
Antiradiation vaccine Technology and development of
prophylaxis prevention and treatment of biological
consequences from Heavy Ion irradiation Available from
httpswwwresearchgatenetpublication253267437_Antiradiatio
n_vaccine_Technology_and_development_of_prophylaxis_preve
ntion_and_treatment_of_biological_consequences_from_Heavy_
Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Methods and experiments
1 The Antiradiation Vaccine preparation -standard (mixture of toxoid form of Radiation Toxins -SRD-group) which include Cerebrovascular RT - Neurotoxin Cardiovascular RT - Neurotoxin Gastrointestinal RT - Neurotoxin Hematopoietic RT - Hematotoxin Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Radiation Toxins Specific Radiation Determinant
Group were isolated from a central lymph of gamma-irradiated animals with Cerebrovascular Cardiovascular Gastrointestiinal Hematopoi-eticforms of ARS Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Devices for gamma-radiation are Panorama
Puma 2 Heavy ion exposure was accomplished at Department of Scientific Research Institute of Nuclear Physics Dubna Russia Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection The heavy ions irradiation was generated in heavy ion
(Fe56) accelerator -UTI Heavy Ion linear transfer energy -2000-2600 KeV mkm 600 MeV U Absorbed Dose -3820 Rad Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Experimental Design Rabbits from all groups were irradiated by
heavy ion accelerator Group A -control -10 rabbits Group B -placebo -5 rabbits Group C -radioprotectant Cystamine (50 mg kg)-5 rabbits 15 minutes before irradiation -5 rabbits Group D -radioprotectant Gammafos (Amifostine -400mg kg ) -5 rabbits Group E -Antiradiation Vaccine subcutaneus administration or IM -2 ml of active substance 14 days before irradiation - 5 rabbits Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Results Group A -100 mortality within two hours after
heavy ion irradiation with clinical symptoms of the acute cerebrovascular and cardiovascular syndromes Group B -100 mortal-ity within 15 hours following irradiation Group C -100 mortality within 14-15 hours after irradiation Group D -100 mortality within 15-16 hours after irradiation Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection In groups A-D development of the acute radiation
cerebrovascular and cardiovascular syndromes as well as ex-tensive burns of skin caused rapid death Group E -100 mortality in 280-290 hours (12 days) following heavy ion irradiation while animals were exhibiting a combination or individual forms of the acute cerebrovascular cardiovascular and gastrointestinal forms and focal skin burns Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Discussion The Antiradiation Vaccine (ARV) and
specific immune-prophylaxis are an effective method of neutralization of Radiation Toxins Vaccination with the ARV significantly extended the survival time after irradiation with heavy ions from two hours up to 300 hours Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Clinical signs clinical features symptoms were somewhat
attenuated Degree of clinical forms of the Acute Radiation Syndromes were diminished in their severity Groups A-D demonstrated an extremely severe degree (Degree 4) of Cerebrovascular and Cardiovascular forms of the Acute Radiation Syndromes and lethality 100 was registered in a short time after irradiation Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Radi-ation induced burns in this groups (with
Cutaneous sub-syndrome of ARS -Degree 4) that were deep with extensive and total dysfunction and possible muscle involvement developed Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Animals from group E -Radioprotectant -anti-radiation vaccine
had demonstrated later development of the severe Degree 3 or even Degree 2-3 forms of Cerebrovascular and Cardiovascular forms of the ARS and a survival time of irradiated animals was significantly prolonged Cutaneous sub-syndrome developed in Degree 3 or Degree 2-3 Our results have demonstrated the potential radioprotection efficacy of specific immune-prophylaxis with the Antiradiation vaccine against heavy ion irradiation Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection
Antiradiation vaccine Technology and
development of prophylaxis prevention and
treatment of biological consequences from
Heavy Ion irradiation
Hadrons
Hadrons are subatomic particles that can take
part in the strong interaction ndash the force that binds
protons inside the nuclei of atoms Physicists
have theorized since the 1960s and ample
experimental evidence since has confirmed
that hadrons are made up of quarks and
antiquarks that determine their properties Apr 9
2014
CERN
Hadrons
Hadrons are categorized into two
families baryons (such as protons and neutrons
made of three quarks) and mesons (such
as pions made of one quark and one antiquark)
A tetraquark state (an exotic meson) named
the Z(4430)minus was discovered in 2014 by
the LHCb collaboration
Hadrons
According to the quark model the properties of
hadrons are primarily determined by their so-
called valence quarks For example a proton is
composed of two up quarks (each with electric
charge +2frasl3 for a total of +4frasl3 together) and
one down quark (with electric charge minus1frasl3) Adding
these together yields the proton charge of +1
httpenwikipediaorgwikiHadron
Hadrons Medical Therapy
Radiation therapy is the medical use of ionizing
radiation to treat cancer In conventional radiation
therapy beams of X rays (high energy photons)
are produced by accelerated electrons and then
delivered to the patient to destroy tumour cells
Using crossing beams from many angles
radiation oncologists irradiate the tumour target
while trying to spare the surrounding normal
tissues Inevitably some radiation dose is always
deposited in the healthy tissues
httpenlightwebcernchwhat-is-hadron-therapy
Hadrons Heavy charged particles produce biological damage that is
different from that normally produced by sparsely ionizing radiation such as x- or gamma-rays DNA lesions are exquisitely complex and difficult to repair Relative biological effectiveness (RBE) factors are normally used to scale from x-rays to heavy ion damage but it should be kept in mind that RBE depends on several factors (dose dose rate endpoint particle energy and charge etc) and sometimes heavy ions produce special damages that just cannot be scaled by x-ray damage alone These special characteristics of heavy ions can be used to treat tumors efficiently as it is currently done in Japan and Germany but they represent a threat for human space exploration Health Phys 2012 Nov103(5)532-9 doi 101097HP0b013e318264b4b6
Eighth Warren K Sinclair keynote address Heavy ions in therapy and space benefits and risks
Durante M
Hadrons
When the irradiating beams are made of charged
particles (protons and other ions such as
carbon) radiation therapy is called hadron-
therapy The strength of hadron-therapy lies in the
unique physical and radiobiological properties of
these particles they can penetrate the tissues
with little diffusion and deposit the maximum
energy just before stopping
httpenlightwebcernchwhat-is-hadron-therapy
Hadrons Space Radiation Life Sci Space Res 197513187-93
Peculiarities of biological action of hadrons of space radiation
Akoev IG1 Yurov SS
Biological investigations in space enable one to make a significant contribution on high-energy hadrons to biological effects under the influence of factors of space flights Physical and molecular principles of the action of high-energy hadrons are analysed Genetic and somatic hadron effects produced by the secondary radiation from 70 GeV protons have been studied experimentally The high biological effectiveness of hadrons great variability in biological effects and specifically of their action are associated with strong interactions of high-energy hadrons These are the probability of nuclear interaction with any atom nucleus generation of a great number of secondary particles (among them probably highly effective multicharged and heavy nuclei antiprotons pi(-)-mesons) and the spatial distribution of secondary particles as a narrow cone with extremely high density of particles in its first part The secondary radiation generated by high- and superhigh-energy hadrons upon their interaction with the spaceship is likely to be the greatest hazard of radiation to the crew during space flights
Hadrons Radiation Protection Introduction An anti-radiation vaccine could be an
important part of a countermeasures reg-imen for effective radioprotection immunoprophylaxis and immunotherapy of the acute radi-ation syndromes (ARS) after gamma-irradiation neutron irradiation or heavy ion irradiation Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Reliable protection of non-neoplastic regions of patients with
different forms of cancer which undergo to heavy ion therapy (
eg Hadron-therapy) can significantly extend the efficiency of the
therapeutic course The protection of cosmonauts astronauts
from the heavy ion radiation component of space radiation with
specific immunoprophylaxis by the anti-radiation vaccine may be
an important part of medical management for long term space
missions
Antiradiation vaccine Technology and development of
prophylaxis prevention and treatment of biological
consequences from Heavy Ion irradiation Available from
httpswwwresearchgatenetpublication253267437_Antiradiatio
n_vaccine_Technology_and_development_of_prophylaxis_preve
ntion_and_treatment_of_biological_consequences_from_Heavy_
Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Methods and experiments
1 The Antiradiation Vaccine preparation -standard (mixture of toxoid form of Radiation Toxins -SRD-group) which include Cerebrovascular RT - Neurotoxin Cardiovascular RT - Neurotoxin Gastrointestinal RT - Neurotoxin Hematopoietic RT - Hematotoxin Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Radiation Toxins Specific Radiation Determinant
Group were isolated from a central lymph of gamma-irradiated animals with Cerebrovascular Cardiovascular Gastrointestiinal Hematopoi-eticforms of ARS Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Devices for gamma-radiation are Panorama
Puma 2 Heavy ion exposure was accomplished at Department of Scientific Research Institute of Nuclear Physics Dubna Russia Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection The heavy ions irradiation was generated in heavy ion
(Fe56) accelerator -UTI Heavy Ion linear transfer energy -2000-2600 KeV mkm 600 MeV U Absorbed Dose -3820 Rad Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Experimental Design Rabbits from all groups were irradiated by
heavy ion accelerator Group A -control -10 rabbits Group B -placebo -5 rabbits Group C -radioprotectant Cystamine (50 mg kg)-5 rabbits 15 minutes before irradiation -5 rabbits Group D -radioprotectant Gammafos (Amifostine -400mg kg ) -5 rabbits Group E -Antiradiation Vaccine subcutaneus administration or IM -2 ml of active substance 14 days before irradiation - 5 rabbits Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Results Group A -100 mortality within two hours after
heavy ion irradiation with clinical symptoms of the acute cerebrovascular and cardiovascular syndromes Group B -100 mortal-ity within 15 hours following irradiation Group C -100 mortality within 14-15 hours after irradiation Group D -100 mortality within 15-16 hours after irradiation Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection In groups A-D development of the acute radiation
cerebrovascular and cardiovascular syndromes as well as ex-tensive burns of skin caused rapid death Group E -100 mortality in 280-290 hours (12 days) following heavy ion irradiation while animals were exhibiting a combination or individual forms of the acute cerebrovascular cardiovascular and gastrointestinal forms and focal skin burns Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Discussion The Antiradiation Vaccine (ARV) and
specific immune-prophylaxis are an effective method of neutralization of Radiation Toxins Vaccination with the ARV significantly extended the survival time after irradiation with heavy ions from two hours up to 300 hours Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Clinical signs clinical features symptoms were somewhat
attenuated Degree of clinical forms of the Acute Radiation Syndromes were diminished in their severity Groups A-D demonstrated an extremely severe degree (Degree 4) of Cerebrovascular and Cardiovascular forms of the Acute Radiation Syndromes and lethality 100 was registered in a short time after irradiation Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Radi-ation induced burns in this groups (with
Cutaneous sub-syndrome of ARS -Degree 4) that were deep with extensive and total dysfunction and possible muscle involvement developed Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Animals from group E -Radioprotectant -anti-radiation vaccine
had demonstrated later development of the severe Degree 3 or even Degree 2-3 forms of Cerebrovascular and Cardiovascular forms of the ARS and a survival time of irradiated animals was significantly prolonged Cutaneous sub-syndrome developed in Degree 3 or Degree 2-3 Our results have demonstrated the potential radioprotection efficacy of specific immune-prophylaxis with the Antiradiation vaccine against heavy ion irradiation Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons
Hadrons are subatomic particles that can take
part in the strong interaction ndash the force that binds
protons inside the nuclei of atoms Physicists
have theorized since the 1960s and ample
experimental evidence since has confirmed
that hadrons are made up of quarks and
antiquarks that determine their properties Apr 9
2014
CERN
Hadrons
Hadrons are categorized into two
families baryons (such as protons and neutrons
made of three quarks) and mesons (such
as pions made of one quark and one antiquark)
A tetraquark state (an exotic meson) named
the Z(4430)minus was discovered in 2014 by
the LHCb collaboration
Hadrons
According to the quark model the properties of
hadrons are primarily determined by their so-
called valence quarks For example a proton is
composed of two up quarks (each with electric
charge +2frasl3 for a total of +4frasl3 together) and
one down quark (with electric charge minus1frasl3) Adding
these together yields the proton charge of +1
httpenwikipediaorgwikiHadron
Hadrons Medical Therapy
Radiation therapy is the medical use of ionizing
radiation to treat cancer In conventional radiation
therapy beams of X rays (high energy photons)
are produced by accelerated electrons and then
delivered to the patient to destroy tumour cells
Using crossing beams from many angles
radiation oncologists irradiate the tumour target
while trying to spare the surrounding normal
tissues Inevitably some radiation dose is always
deposited in the healthy tissues
httpenlightwebcernchwhat-is-hadron-therapy
Hadrons Heavy charged particles produce biological damage that is
different from that normally produced by sparsely ionizing radiation such as x- or gamma-rays DNA lesions are exquisitely complex and difficult to repair Relative biological effectiveness (RBE) factors are normally used to scale from x-rays to heavy ion damage but it should be kept in mind that RBE depends on several factors (dose dose rate endpoint particle energy and charge etc) and sometimes heavy ions produce special damages that just cannot be scaled by x-ray damage alone These special characteristics of heavy ions can be used to treat tumors efficiently as it is currently done in Japan and Germany but they represent a threat for human space exploration Health Phys 2012 Nov103(5)532-9 doi 101097HP0b013e318264b4b6
Eighth Warren K Sinclair keynote address Heavy ions in therapy and space benefits and risks
Durante M
Hadrons
When the irradiating beams are made of charged
particles (protons and other ions such as
carbon) radiation therapy is called hadron-
therapy The strength of hadron-therapy lies in the
unique physical and radiobiological properties of
these particles they can penetrate the tissues
with little diffusion and deposit the maximum
energy just before stopping
httpenlightwebcernchwhat-is-hadron-therapy
Hadrons Space Radiation Life Sci Space Res 197513187-93
Peculiarities of biological action of hadrons of space radiation
Akoev IG1 Yurov SS
Biological investigations in space enable one to make a significant contribution on high-energy hadrons to biological effects under the influence of factors of space flights Physical and molecular principles of the action of high-energy hadrons are analysed Genetic and somatic hadron effects produced by the secondary radiation from 70 GeV protons have been studied experimentally The high biological effectiveness of hadrons great variability in biological effects and specifically of their action are associated with strong interactions of high-energy hadrons These are the probability of nuclear interaction with any atom nucleus generation of a great number of secondary particles (among them probably highly effective multicharged and heavy nuclei antiprotons pi(-)-mesons) and the spatial distribution of secondary particles as a narrow cone with extremely high density of particles in its first part The secondary radiation generated by high- and superhigh-energy hadrons upon their interaction with the spaceship is likely to be the greatest hazard of radiation to the crew during space flights
Hadrons Radiation Protection Introduction An anti-radiation vaccine could be an
important part of a countermeasures reg-imen for effective radioprotection immunoprophylaxis and immunotherapy of the acute radi-ation syndromes (ARS) after gamma-irradiation neutron irradiation or heavy ion irradiation Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Reliable protection of non-neoplastic regions of patients with
different forms of cancer which undergo to heavy ion therapy (
eg Hadron-therapy) can significantly extend the efficiency of the
therapeutic course The protection of cosmonauts astronauts
from the heavy ion radiation component of space radiation with
specific immunoprophylaxis by the anti-radiation vaccine may be
an important part of medical management for long term space
missions
Antiradiation vaccine Technology and development of
prophylaxis prevention and treatment of biological
consequences from Heavy Ion irradiation Available from
httpswwwresearchgatenetpublication253267437_Antiradiatio
n_vaccine_Technology_and_development_of_prophylaxis_preve
ntion_and_treatment_of_biological_consequences_from_Heavy_
Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Methods and experiments
1 The Antiradiation Vaccine preparation -standard (mixture of toxoid form of Radiation Toxins -SRD-group) which include Cerebrovascular RT - Neurotoxin Cardiovascular RT - Neurotoxin Gastrointestinal RT - Neurotoxin Hematopoietic RT - Hematotoxin Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Radiation Toxins Specific Radiation Determinant
Group were isolated from a central lymph of gamma-irradiated animals with Cerebrovascular Cardiovascular Gastrointestiinal Hematopoi-eticforms of ARS Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Devices for gamma-radiation are Panorama
Puma 2 Heavy ion exposure was accomplished at Department of Scientific Research Institute of Nuclear Physics Dubna Russia Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection The heavy ions irradiation was generated in heavy ion
(Fe56) accelerator -UTI Heavy Ion linear transfer energy -2000-2600 KeV mkm 600 MeV U Absorbed Dose -3820 Rad Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Experimental Design Rabbits from all groups were irradiated by
heavy ion accelerator Group A -control -10 rabbits Group B -placebo -5 rabbits Group C -radioprotectant Cystamine (50 mg kg)-5 rabbits 15 minutes before irradiation -5 rabbits Group D -radioprotectant Gammafos (Amifostine -400mg kg ) -5 rabbits Group E -Antiradiation Vaccine subcutaneus administration or IM -2 ml of active substance 14 days before irradiation - 5 rabbits Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Results Group A -100 mortality within two hours after
heavy ion irradiation with clinical symptoms of the acute cerebrovascular and cardiovascular syndromes Group B -100 mortal-ity within 15 hours following irradiation Group C -100 mortality within 14-15 hours after irradiation Group D -100 mortality within 15-16 hours after irradiation Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection In groups A-D development of the acute radiation
cerebrovascular and cardiovascular syndromes as well as ex-tensive burns of skin caused rapid death Group E -100 mortality in 280-290 hours (12 days) following heavy ion irradiation while animals were exhibiting a combination or individual forms of the acute cerebrovascular cardiovascular and gastrointestinal forms and focal skin burns Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Discussion The Antiradiation Vaccine (ARV) and
specific immune-prophylaxis are an effective method of neutralization of Radiation Toxins Vaccination with the ARV significantly extended the survival time after irradiation with heavy ions from two hours up to 300 hours Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Clinical signs clinical features symptoms were somewhat
attenuated Degree of clinical forms of the Acute Radiation Syndromes were diminished in their severity Groups A-D demonstrated an extremely severe degree (Degree 4) of Cerebrovascular and Cardiovascular forms of the Acute Radiation Syndromes and lethality 100 was registered in a short time after irradiation Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Radi-ation induced burns in this groups (with
Cutaneous sub-syndrome of ARS -Degree 4) that were deep with extensive and total dysfunction and possible muscle involvement developed Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Animals from group E -Radioprotectant -anti-radiation vaccine
had demonstrated later development of the severe Degree 3 or even Degree 2-3 forms of Cerebrovascular and Cardiovascular forms of the ARS and a survival time of irradiated animals was significantly prolonged Cutaneous sub-syndrome developed in Degree 3 or Degree 2-3 Our results have demonstrated the potential radioprotection efficacy of specific immune-prophylaxis with the Antiradiation vaccine against heavy ion irradiation Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons
Hadrons are categorized into two
families baryons (such as protons and neutrons
made of three quarks) and mesons (such
as pions made of one quark and one antiquark)
A tetraquark state (an exotic meson) named
the Z(4430)minus was discovered in 2014 by
the LHCb collaboration
Hadrons
According to the quark model the properties of
hadrons are primarily determined by their so-
called valence quarks For example a proton is
composed of two up quarks (each with electric
charge +2frasl3 for a total of +4frasl3 together) and
one down quark (with electric charge minus1frasl3) Adding
these together yields the proton charge of +1
httpenwikipediaorgwikiHadron
Hadrons Medical Therapy
Radiation therapy is the medical use of ionizing
radiation to treat cancer In conventional radiation
therapy beams of X rays (high energy photons)
are produced by accelerated electrons and then
delivered to the patient to destroy tumour cells
Using crossing beams from many angles
radiation oncologists irradiate the tumour target
while trying to spare the surrounding normal
tissues Inevitably some radiation dose is always
deposited in the healthy tissues
httpenlightwebcernchwhat-is-hadron-therapy
Hadrons Heavy charged particles produce biological damage that is
different from that normally produced by sparsely ionizing radiation such as x- or gamma-rays DNA lesions are exquisitely complex and difficult to repair Relative biological effectiveness (RBE) factors are normally used to scale from x-rays to heavy ion damage but it should be kept in mind that RBE depends on several factors (dose dose rate endpoint particle energy and charge etc) and sometimes heavy ions produce special damages that just cannot be scaled by x-ray damage alone These special characteristics of heavy ions can be used to treat tumors efficiently as it is currently done in Japan and Germany but they represent a threat for human space exploration Health Phys 2012 Nov103(5)532-9 doi 101097HP0b013e318264b4b6
Eighth Warren K Sinclair keynote address Heavy ions in therapy and space benefits and risks
Durante M
Hadrons
When the irradiating beams are made of charged
particles (protons and other ions such as
carbon) radiation therapy is called hadron-
therapy The strength of hadron-therapy lies in the
unique physical and radiobiological properties of
these particles they can penetrate the tissues
with little diffusion and deposit the maximum
energy just before stopping
httpenlightwebcernchwhat-is-hadron-therapy
Hadrons Space Radiation Life Sci Space Res 197513187-93
Peculiarities of biological action of hadrons of space radiation
Akoev IG1 Yurov SS
Biological investigations in space enable one to make a significant contribution on high-energy hadrons to biological effects under the influence of factors of space flights Physical and molecular principles of the action of high-energy hadrons are analysed Genetic and somatic hadron effects produced by the secondary radiation from 70 GeV protons have been studied experimentally The high biological effectiveness of hadrons great variability in biological effects and specifically of their action are associated with strong interactions of high-energy hadrons These are the probability of nuclear interaction with any atom nucleus generation of a great number of secondary particles (among them probably highly effective multicharged and heavy nuclei antiprotons pi(-)-mesons) and the spatial distribution of secondary particles as a narrow cone with extremely high density of particles in its first part The secondary radiation generated by high- and superhigh-energy hadrons upon their interaction with the spaceship is likely to be the greatest hazard of radiation to the crew during space flights
Hadrons Radiation Protection Introduction An anti-radiation vaccine could be an
important part of a countermeasures reg-imen for effective radioprotection immunoprophylaxis and immunotherapy of the acute radi-ation syndromes (ARS) after gamma-irradiation neutron irradiation or heavy ion irradiation Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Reliable protection of non-neoplastic regions of patients with
different forms of cancer which undergo to heavy ion therapy (
eg Hadron-therapy) can significantly extend the efficiency of the
therapeutic course The protection of cosmonauts astronauts
from the heavy ion radiation component of space radiation with
specific immunoprophylaxis by the anti-radiation vaccine may be
an important part of medical management for long term space
missions
Antiradiation vaccine Technology and development of
prophylaxis prevention and treatment of biological
consequences from Heavy Ion irradiation Available from
httpswwwresearchgatenetpublication253267437_Antiradiatio
n_vaccine_Technology_and_development_of_prophylaxis_preve
ntion_and_treatment_of_biological_consequences_from_Heavy_
Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Methods and experiments
1 The Antiradiation Vaccine preparation -standard (mixture of toxoid form of Radiation Toxins -SRD-group) which include Cerebrovascular RT - Neurotoxin Cardiovascular RT - Neurotoxin Gastrointestinal RT - Neurotoxin Hematopoietic RT - Hematotoxin Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Radiation Toxins Specific Radiation Determinant
Group were isolated from a central lymph of gamma-irradiated animals with Cerebrovascular Cardiovascular Gastrointestiinal Hematopoi-eticforms of ARS Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Devices for gamma-radiation are Panorama
Puma 2 Heavy ion exposure was accomplished at Department of Scientific Research Institute of Nuclear Physics Dubna Russia Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection The heavy ions irradiation was generated in heavy ion
(Fe56) accelerator -UTI Heavy Ion linear transfer energy -2000-2600 KeV mkm 600 MeV U Absorbed Dose -3820 Rad Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Experimental Design Rabbits from all groups were irradiated by
heavy ion accelerator Group A -control -10 rabbits Group B -placebo -5 rabbits Group C -radioprotectant Cystamine (50 mg kg)-5 rabbits 15 minutes before irradiation -5 rabbits Group D -radioprotectant Gammafos (Amifostine -400mg kg ) -5 rabbits Group E -Antiradiation Vaccine subcutaneus administration or IM -2 ml of active substance 14 days before irradiation - 5 rabbits Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Results Group A -100 mortality within two hours after
heavy ion irradiation with clinical symptoms of the acute cerebrovascular and cardiovascular syndromes Group B -100 mortal-ity within 15 hours following irradiation Group C -100 mortality within 14-15 hours after irradiation Group D -100 mortality within 15-16 hours after irradiation Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection In groups A-D development of the acute radiation
cerebrovascular and cardiovascular syndromes as well as ex-tensive burns of skin caused rapid death Group E -100 mortality in 280-290 hours (12 days) following heavy ion irradiation while animals were exhibiting a combination or individual forms of the acute cerebrovascular cardiovascular and gastrointestinal forms and focal skin burns Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Discussion The Antiradiation Vaccine (ARV) and
specific immune-prophylaxis are an effective method of neutralization of Radiation Toxins Vaccination with the ARV significantly extended the survival time after irradiation with heavy ions from two hours up to 300 hours Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Clinical signs clinical features symptoms were somewhat
attenuated Degree of clinical forms of the Acute Radiation Syndromes were diminished in their severity Groups A-D demonstrated an extremely severe degree (Degree 4) of Cerebrovascular and Cardiovascular forms of the Acute Radiation Syndromes and lethality 100 was registered in a short time after irradiation Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Radi-ation induced burns in this groups (with
Cutaneous sub-syndrome of ARS -Degree 4) that were deep with extensive and total dysfunction and possible muscle involvement developed Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Animals from group E -Radioprotectant -anti-radiation vaccine
had demonstrated later development of the severe Degree 3 or even Degree 2-3 forms of Cerebrovascular and Cardiovascular forms of the ARS and a survival time of irradiated animals was significantly prolonged Cutaneous sub-syndrome developed in Degree 3 or Degree 2-3 Our results have demonstrated the potential radioprotection efficacy of specific immune-prophylaxis with the Antiradiation vaccine against heavy ion irradiation Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons
According to the quark model the properties of
hadrons are primarily determined by their so-
called valence quarks For example a proton is
composed of two up quarks (each with electric
charge +2frasl3 for a total of +4frasl3 together) and
one down quark (with electric charge minus1frasl3) Adding
these together yields the proton charge of +1
httpenwikipediaorgwikiHadron
Hadrons Medical Therapy
Radiation therapy is the medical use of ionizing
radiation to treat cancer In conventional radiation
therapy beams of X rays (high energy photons)
are produced by accelerated electrons and then
delivered to the patient to destroy tumour cells
Using crossing beams from many angles
radiation oncologists irradiate the tumour target
while trying to spare the surrounding normal
tissues Inevitably some radiation dose is always
deposited in the healthy tissues
httpenlightwebcernchwhat-is-hadron-therapy
Hadrons Heavy charged particles produce biological damage that is
different from that normally produced by sparsely ionizing radiation such as x- or gamma-rays DNA lesions are exquisitely complex and difficult to repair Relative biological effectiveness (RBE) factors are normally used to scale from x-rays to heavy ion damage but it should be kept in mind that RBE depends on several factors (dose dose rate endpoint particle energy and charge etc) and sometimes heavy ions produce special damages that just cannot be scaled by x-ray damage alone These special characteristics of heavy ions can be used to treat tumors efficiently as it is currently done in Japan and Germany but they represent a threat for human space exploration Health Phys 2012 Nov103(5)532-9 doi 101097HP0b013e318264b4b6
Eighth Warren K Sinclair keynote address Heavy ions in therapy and space benefits and risks
Durante M
Hadrons
When the irradiating beams are made of charged
particles (protons and other ions such as
carbon) radiation therapy is called hadron-
therapy The strength of hadron-therapy lies in the
unique physical and radiobiological properties of
these particles they can penetrate the tissues
with little diffusion and deposit the maximum
energy just before stopping
httpenlightwebcernchwhat-is-hadron-therapy
Hadrons Space Radiation Life Sci Space Res 197513187-93
Peculiarities of biological action of hadrons of space radiation
Akoev IG1 Yurov SS
Biological investigations in space enable one to make a significant contribution on high-energy hadrons to biological effects under the influence of factors of space flights Physical and molecular principles of the action of high-energy hadrons are analysed Genetic and somatic hadron effects produced by the secondary radiation from 70 GeV protons have been studied experimentally The high biological effectiveness of hadrons great variability in biological effects and specifically of their action are associated with strong interactions of high-energy hadrons These are the probability of nuclear interaction with any atom nucleus generation of a great number of secondary particles (among them probably highly effective multicharged and heavy nuclei antiprotons pi(-)-mesons) and the spatial distribution of secondary particles as a narrow cone with extremely high density of particles in its first part The secondary radiation generated by high- and superhigh-energy hadrons upon their interaction with the spaceship is likely to be the greatest hazard of radiation to the crew during space flights
Hadrons Radiation Protection Introduction An anti-radiation vaccine could be an
important part of a countermeasures reg-imen for effective radioprotection immunoprophylaxis and immunotherapy of the acute radi-ation syndromes (ARS) after gamma-irradiation neutron irradiation or heavy ion irradiation Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Reliable protection of non-neoplastic regions of patients with
different forms of cancer which undergo to heavy ion therapy (
eg Hadron-therapy) can significantly extend the efficiency of the
therapeutic course The protection of cosmonauts astronauts
from the heavy ion radiation component of space radiation with
specific immunoprophylaxis by the anti-radiation vaccine may be
an important part of medical management for long term space
missions
Antiradiation vaccine Technology and development of
prophylaxis prevention and treatment of biological
consequences from Heavy Ion irradiation Available from
httpswwwresearchgatenetpublication253267437_Antiradiatio
n_vaccine_Technology_and_development_of_prophylaxis_preve
ntion_and_treatment_of_biological_consequences_from_Heavy_
Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Methods and experiments
1 The Antiradiation Vaccine preparation -standard (mixture of toxoid form of Radiation Toxins -SRD-group) which include Cerebrovascular RT - Neurotoxin Cardiovascular RT - Neurotoxin Gastrointestinal RT - Neurotoxin Hematopoietic RT - Hematotoxin Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Radiation Toxins Specific Radiation Determinant
Group were isolated from a central lymph of gamma-irradiated animals with Cerebrovascular Cardiovascular Gastrointestiinal Hematopoi-eticforms of ARS Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Devices for gamma-radiation are Panorama
Puma 2 Heavy ion exposure was accomplished at Department of Scientific Research Institute of Nuclear Physics Dubna Russia Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection The heavy ions irradiation was generated in heavy ion
(Fe56) accelerator -UTI Heavy Ion linear transfer energy -2000-2600 KeV mkm 600 MeV U Absorbed Dose -3820 Rad Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Experimental Design Rabbits from all groups were irradiated by
heavy ion accelerator Group A -control -10 rabbits Group B -placebo -5 rabbits Group C -radioprotectant Cystamine (50 mg kg)-5 rabbits 15 minutes before irradiation -5 rabbits Group D -radioprotectant Gammafos (Amifostine -400mg kg ) -5 rabbits Group E -Antiradiation Vaccine subcutaneus administration or IM -2 ml of active substance 14 days before irradiation - 5 rabbits Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Results Group A -100 mortality within two hours after
heavy ion irradiation with clinical symptoms of the acute cerebrovascular and cardiovascular syndromes Group B -100 mortal-ity within 15 hours following irradiation Group C -100 mortality within 14-15 hours after irradiation Group D -100 mortality within 15-16 hours after irradiation Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection In groups A-D development of the acute radiation
cerebrovascular and cardiovascular syndromes as well as ex-tensive burns of skin caused rapid death Group E -100 mortality in 280-290 hours (12 days) following heavy ion irradiation while animals were exhibiting a combination or individual forms of the acute cerebrovascular cardiovascular and gastrointestinal forms and focal skin burns Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Discussion The Antiradiation Vaccine (ARV) and
specific immune-prophylaxis are an effective method of neutralization of Radiation Toxins Vaccination with the ARV significantly extended the survival time after irradiation with heavy ions from two hours up to 300 hours Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Clinical signs clinical features symptoms were somewhat
attenuated Degree of clinical forms of the Acute Radiation Syndromes were diminished in their severity Groups A-D demonstrated an extremely severe degree (Degree 4) of Cerebrovascular and Cardiovascular forms of the Acute Radiation Syndromes and lethality 100 was registered in a short time after irradiation Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Radi-ation induced burns in this groups (with
Cutaneous sub-syndrome of ARS -Degree 4) that were deep with extensive and total dysfunction and possible muscle involvement developed Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Animals from group E -Radioprotectant -anti-radiation vaccine
had demonstrated later development of the severe Degree 3 or even Degree 2-3 forms of Cerebrovascular and Cardiovascular forms of the ARS and a survival time of irradiated animals was significantly prolonged Cutaneous sub-syndrome developed in Degree 3 or Degree 2-3 Our results have demonstrated the potential radioprotection efficacy of specific immune-prophylaxis with the Antiradiation vaccine against heavy ion irradiation Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Medical Therapy
Radiation therapy is the medical use of ionizing
radiation to treat cancer In conventional radiation
therapy beams of X rays (high energy photons)
are produced by accelerated electrons and then
delivered to the patient to destroy tumour cells
Using crossing beams from many angles
radiation oncologists irradiate the tumour target
while trying to spare the surrounding normal
tissues Inevitably some radiation dose is always
deposited in the healthy tissues
httpenlightwebcernchwhat-is-hadron-therapy
Hadrons Heavy charged particles produce biological damage that is
different from that normally produced by sparsely ionizing radiation such as x- or gamma-rays DNA lesions are exquisitely complex and difficult to repair Relative biological effectiveness (RBE) factors are normally used to scale from x-rays to heavy ion damage but it should be kept in mind that RBE depends on several factors (dose dose rate endpoint particle energy and charge etc) and sometimes heavy ions produce special damages that just cannot be scaled by x-ray damage alone These special characteristics of heavy ions can be used to treat tumors efficiently as it is currently done in Japan and Germany but they represent a threat for human space exploration Health Phys 2012 Nov103(5)532-9 doi 101097HP0b013e318264b4b6
Eighth Warren K Sinclair keynote address Heavy ions in therapy and space benefits and risks
Durante M
Hadrons
When the irradiating beams are made of charged
particles (protons and other ions such as
carbon) radiation therapy is called hadron-
therapy The strength of hadron-therapy lies in the
unique physical and radiobiological properties of
these particles they can penetrate the tissues
with little diffusion and deposit the maximum
energy just before stopping
httpenlightwebcernchwhat-is-hadron-therapy
Hadrons Space Radiation Life Sci Space Res 197513187-93
Peculiarities of biological action of hadrons of space radiation
Akoev IG1 Yurov SS
Biological investigations in space enable one to make a significant contribution on high-energy hadrons to biological effects under the influence of factors of space flights Physical and molecular principles of the action of high-energy hadrons are analysed Genetic and somatic hadron effects produced by the secondary radiation from 70 GeV protons have been studied experimentally The high biological effectiveness of hadrons great variability in biological effects and specifically of their action are associated with strong interactions of high-energy hadrons These are the probability of nuclear interaction with any atom nucleus generation of a great number of secondary particles (among them probably highly effective multicharged and heavy nuclei antiprotons pi(-)-mesons) and the spatial distribution of secondary particles as a narrow cone with extremely high density of particles in its first part The secondary radiation generated by high- and superhigh-energy hadrons upon their interaction with the spaceship is likely to be the greatest hazard of radiation to the crew during space flights
Hadrons Radiation Protection Introduction An anti-radiation vaccine could be an
important part of a countermeasures reg-imen for effective radioprotection immunoprophylaxis and immunotherapy of the acute radi-ation syndromes (ARS) after gamma-irradiation neutron irradiation or heavy ion irradiation Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Reliable protection of non-neoplastic regions of patients with
different forms of cancer which undergo to heavy ion therapy (
eg Hadron-therapy) can significantly extend the efficiency of the
therapeutic course The protection of cosmonauts astronauts
from the heavy ion radiation component of space radiation with
specific immunoprophylaxis by the anti-radiation vaccine may be
an important part of medical management for long term space
missions
Antiradiation vaccine Technology and development of
prophylaxis prevention and treatment of biological
consequences from Heavy Ion irradiation Available from
httpswwwresearchgatenetpublication253267437_Antiradiatio
n_vaccine_Technology_and_development_of_prophylaxis_preve
ntion_and_treatment_of_biological_consequences_from_Heavy_
Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Methods and experiments
1 The Antiradiation Vaccine preparation -standard (mixture of toxoid form of Radiation Toxins -SRD-group) which include Cerebrovascular RT - Neurotoxin Cardiovascular RT - Neurotoxin Gastrointestinal RT - Neurotoxin Hematopoietic RT - Hematotoxin Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Radiation Toxins Specific Radiation Determinant
Group were isolated from a central lymph of gamma-irradiated animals with Cerebrovascular Cardiovascular Gastrointestiinal Hematopoi-eticforms of ARS Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Devices for gamma-radiation are Panorama
Puma 2 Heavy ion exposure was accomplished at Department of Scientific Research Institute of Nuclear Physics Dubna Russia Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection The heavy ions irradiation was generated in heavy ion
(Fe56) accelerator -UTI Heavy Ion linear transfer energy -2000-2600 KeV mkm 600 MeV U Absorbed Dose -3820 Rad Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Experimental Design Rabbits from all groups were irradiated by
heavy ion accelerator Group A -control -10 rabbits Group B -placebo -5 rabbits Group C -radioprotectant Cystamine (50 mg kg)-5 rabbits 15 minutes before irradiation -5 rabbits Group D -radioprotectant Gammafos (Amifostine -400mg kg ) -5 rabbits Group E -Antiradiation Vaccine subcutaneus administration or IM -2 ml of active substance 14 days before irradiation - 5 rabbits Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Results Group A -100 mortality within two hours after
heavy ion irradiation with clinical symptoms of the acute cerebrovascular and cardiovascular syndromes Group B -100 mortal-ity within 15 hours following irradiation Group C -100 mortality within 14-15 hours after irradiation Group D -100 mortality within 15-16 hours after irradiation Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection In groups A-D development of the acute radiation
cerebrovascular and cardiovascular syndromes as well as ex-tensive burns of skin caused rapid death Group E -100 mortality in 280-290 hours (12 days) following heavy ion irradiation while animals were exhibiting a combination or individual forms of the acute cerebrovascular cardiovascular and gastrointestinal forms and focal skin burns Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Discussion The Antiradiation Vaccine (ARV) and
specific immune-prophylaxis are an effective method of neutralization of Radiation Toxins Vaccination with the ARV significantly extended the survival time after irradiation with heavy ions from two hours up to 300 hours Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Clinical signs clinical features symptoms were somewhat
attenuated Degree of clinical forms of the Acute Radiation Syndromes were diminished in their severity Groups A-D demonstrated an extremely severe degree (Degree 4) of Cerebrovascular and Cardiovascular forms of the Acute Radiation Syndromes and lethality 100 was registered in a short time after irradiation Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Radi-ation induced burns in this groups (with
Cutaneous sub-syndrome of ARS -Degree 4) that were deep with extensive and total dysfunction and possible muscle involvement developed Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Animals from group E -Radioprotectant -anti-radiation vaccine
had demonstrated later development of the severe Degree 3 or even Degree 2-3 forms of Cerebrovascular and Cardiovascular forms of the ARS and a survival time of irradiated animals was significantly prolonged Cutaneous sub-syndrome developed in Degree 3 or Degree 2-3 Our results have demonstrated the potential radioprotection efficacy of specific immune-prophylaxis with the Antiradiation vaccine against heavy ion irradiation Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Heavy charged particles produce biological damage that is
different from that normally produced by sparsely ionizing radiation such as x- or gamma-rays DNA lesions are exquisitely complex and difficult to repair Relative biological effectiveness (RBE) factors are normally used to scale from x-rays to heavy ion damage but it should be kept in mind that RBE depends on several factors (dose dose rate endpoint particle energy and charge etc) and sometimes heavy ions produce special damages that just cannot be scaled by x-ray damage alone These special characteristics of heavy ions can be used to treat tumors efficiently as it is currently done in Japan and Germany but they represent a threat for human space exploration Health Phys 2012 Nov103(5)532-9 doi 101097HP0b013e318264b4b6
Eighth Warren K Sinclair keynote address Heavy ions in therapy and space benefits and risks
Durante M
Hadrons
When the irradiating beams are made of charged
particles (protons and other ions such as
carbon) radiation therapy is called hadron-
therapy The strength of hadron-therapy lies in the
unique physical and radiobiological properties of
these particles they can penetrate the tissues
with little diffusion and deposit the maximum
energy just before stopping
httpenlightwebcernchwhat-is-hadron-therapy
Hadrons Space Radiation Life Sci Space Res 197513187-93
Peculiarities of biological action of hadrons of space radiation
Akoev IG1 Yurov SS
Biological investigations in space enable one to make a significant contribution on high-energy hadrons to biological effects under the influence of factors of space flights Physical and molecular principles of the action of high-energy hadrons are analysed Genetic and somatic hadron effects produced by the secondary radiation from 70 GeV protons have been studied experimentally The high biological effectiveness of hadrons great variability in biological effects and specifically of their action are associated with strong interactions of high-energy hadrons These are the probability of nuclear interaction with any atom nucleus generation of a great number of secondary particles (among them probably highly effective multicharged and heavy nuclei antiprotons pi(-)-mesons) and the spatial distribution of secondary particles as a narrow cone with extremely high density of particles in its first part The secondary radiation generated by high- and superhigh-energy hadrons upon their interaction with the spaceship is likely to be the greatest hazard of radiation to the crew during space flights
Hadrons Radiation Protection Introduction An anti-radiation vaccine could be an
important part of a countermeasures reg-imen for effective radioprotection immunoprophylaxis and immunotherapy of the acute radi-ation syndromes (ARS) after gamma-irradiation neutron irradiation or heavy ion irradiation Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Reliable protection of non-neoplastic regions of patients with
different forms of cancer which undergo to heavy ion therapy (
eg Hadron-therapy) can significantly extend the efficiency of the
therapeutic course The protection of cosmonauts astronauts
from the heavy ion radiation component of space radiation with
specific immunoprophylaxis by the anti-radiation vaccine may be
an important part of medical management for long term space
missions
Antiradiation vaccine Technology and development of
prophylaxis prevention and treatment of biological
consequences from Heavy Ion irradiation Available from
httpswwwresearchgatenetpublication253267437_Antiradiatio
n_vaccine_Technology_and_development_of_prophylaxis_preve
ntion_and_treatment_of_biological_consequences_from_Heavy_
Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Methods and experiments
1 The Antiradiation Vaccine preparation -standard (mixture of toxoid form of Radiation Toxins -SRD-group) which include Cerebrovascular RT - Neurotoxin Cardiovascular RT - Neurotoxin Gastrointestinal RT - Neurotoxin Hematopoietic RT - Hematotoxin Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Radiation Toxins Specific Radiation Determinant
Group were isolated from a central lymph of gamma-irradiated animals with Cerebrovascular Cardiovascular Gastrointestiinal Hematopoi-eticforms of ARS Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Devices for gamma-radiation are Panorama
Puma 2 Heavy ion exposure was accomplished at Department of Scientific Research Institute of Nuclear Physics Dubna Russia Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection The heavy ions irradiation was generated in heavy ion
(Fe56) accelerator -UTI Heavy Ion linear transfer energy -2000-2600 KeV mkm 600 MeV U Absorbed Dose -3820 Rad Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Experimental Design Rabbits from all groups were irradiated by
heavy ion accelerator Group A -control -10 rabbits Group B -placebo -5 rabbits Group C -radioprotectant Cystamine (50 mg kg)-5 rabbits 15 minutes before irradiation -5 rabbits Group D -radioprotectant Gammafos (Amifostine -400mg kg ) -5 rabbits Group E -Antiradiation Vaccine subcutaneus administration or IM -2 ml of active substance 14 days before irradiation - 5 rabbits Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Results Group A -100 mortality within two hours after
heavy ion irradiation with clinical symptoms of the acute cerebrovascular and cardiovascular syndromes Group B -100 mortal-ity within 15 hours following irradiation Group C -100 mortality within 14-15 hours after irradiation Group D -100 mortality within 15-16 hours after irradiation Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection In groups A-D development of the acute radiation
cerebrovascular and cardiovascular syndromes as well as ex-tensive burns of skin caused rapid death Group E -100 mortality in 280-290 hours (12 days) following heavy ion irradiation while animals were exhibiting a combination or individual forms of the acute cerebrovascular cardiovascular and gastrointestinal forms and focal skin burns Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Discussion The Antiradiation Vaccine (ARV) and
specific immune-prophylaxis are an effective method of neutralization of Radiation Toxins Vaccination with the ARV significantly extended the survival time after irradiation with heavy ions from two hours up to 300 hours Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Clinical signs clinical features symptoms were somewhat
attenuated Degree of clinical forms of the Acute Radiation Syndromes were diminished in their severity Groups A-D demonstrated an extremely severe degree (Degree 4) of Cerebrovascular and Cardiovascular forms of the Acute Radiation Syndromes and lethality 100 was registered in a short time after irradiation Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Radi-ation induced burns in this groups (with
Cutaneous sub-syndrome of ARS -Degree 4) that were deep with extensive and total dysfunction and possible muscle involvement developed Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Animals from group E -Radioprotectant -anti-radiation vaccine
had demonstrated later development of the severe Degree 3 or even Degree 2-3 forms of Cerebrovascular and Cardiovascular forms of the ARS and a survival time of irradiated animals was significantly prolonged Cutaneous sub-syndrome developed in Degree 3 or Degree 2-3 Our results have demonstrated the potential radioprotection efficacy of specific immune-prophylaxis with the Antiradiation vaccine against heavy ion irradiation Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons
When the irradiating beams are made of charged
particles (protons and other ions such as
carbon) radiation therapy is called hadron-
therapy The strength of hadron-therapy lies in the
unique physical and radiobiological properties of
these particles they can penetrate the tissues
with little diffusion and deposit the maximum
energy just before stopping
httpenlightwebcernchwhat-is-hadron-therapy
Hadrons Space Radiation Life Sci Space Res 197513187-93
Peculiarities of biological action of hadrons of space radiation
Akoev IG1 Yurov SS
Biological investigations in space enable one to make a significant contribution on high-energy hadrons to biological effects under the influence of factors of space flights Physical and molecular principles of the action of high-energy hadrons are analysed Genetic and somatic hadron effects produced by the secondary radiation from 70 GeV protons have been studied experimentally The high biological effectiveness of hadrons great variability in biological effects and specifically of their action are associated with strong interactions of high-energy hadrons These are the probability of nuclear interaction with any atom nucleus generation of a great number of secondary particles (among them probably highly effective multicharged and heavy nuclei antiprotons pi(-)-mesons) and the spatial distribution of secondary particles as a narrow cone with extremely high density of particles in its first part The secondary radiation generated by high- and superhigh-energy hadrons upon their interaction with the spaceship is likely to be the greatest hazard of radiation to the crew during space flights
Hadrons Radiation Protection Introduction An anti-radiation vaccine could be an
important part of a countermeasures reg-imen for effective radioprotection immunoprophylaxis and immunotherapy of the acute radi-ation syndromes (ARS) after gamma-irradiation neutron irradiation or heavy ion irradiation Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Reliable protection of non-neoplastic regions of patients with
different forms of cancer which undergo to heavy ion therapy (
eg Hadron-therapy) can significantly extend the efficiency of the
therapeutic course The protection of cosmonauts astronauts
from the heavy ion radiation component of space radiation with
specific immunoprophylaxis by the anti-radiation vaccine may be
an important part of medical management for long term space
missions
Antiradiation vaccine Technology and development of
prophylaxis prevention and treatment of biological
consequences from Heavy Ion irradiation Available from
httpswwwresearchgatenetpublication253267437_Antiradiatio
n_vaccine_Technology_and_development_of_prophylaxis_preve
ntion_and_treatment_of_biological_consequences_from_Heavy_
Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Methods and experiments
1 The Antiradiation Vaccine preparation -standard (mixture of toxoid form of Radiation Toxins -SRD-group) which include Cerebrovascular RT - Neurotoxin Cardiovascular RT - Neurotoxin Gastrointestinal RT - Neurotoxin Hematopoietic RT - Hematotoxin Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Radiation Toxins Specific Radiation Determinant
Group were isolated from a central lymph of gamma-irradiated animals with Cerebrovascular Cardiovascular Gastrointestiinal Hematopoi-eticforms of ARS Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Devices for gamma-radiation are Panorama
Puma 2 Heavy ion exposure was accomplished at Department of Scientific Research Institute of Nuclear Physics Dubna Russia Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection The heavy ions irradiation was generated in heavy ion
(Fe56) accelerator -UTI Heavy Ion linear transfer energy -2000-2600 KeV mkm 600 MeV U Absorbed Dose -3820 Rad Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Experimental Design Rabbits from all groups were irradiated by
heavy ion accelerator Group A -control -10 rabbits Group B -placebo -5 rabbits Group C -radioprotectant Cystamine (50 mg kg)-5 rabbits 15 minutes before irradiation -5 rabbits Group D -radioprotectant Gammafos (Amifostine -400mg kg ) -5 rabbits Group E -Antiradiation Vaccine subcutaneus administration or IM -2 ml of active substance 14 days before irradiation - 5 rabbits Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Results Group A -100 mortality within two hours after
heavy ion irradiation with clinical symptoms of the acute cerebrovascular and cardiovascular syndromes Group B -100 mortal-ity within 15 hours following irradiation Group C -100 mortality within 14-15 hours after irradiation Group D -100 mortality within 15-16 hours after irradiation Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection In groups A-D development of the acute radiation
cerebrovascular and cardiovascular syndromes as well as ex-tensive burns of skin caused rapid death Group E -100 mortality in 280-290 hours (12 days) following heavy ion irradiation while animals were exhibiting a combination or individual forms of the acute cerebrovascular cardiovascular and gastrointestinal forms and focal skin burns Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Discussion The Antiradiation Vaccine (ARV) and
specific immune-prophylaxis are an effective method of neutralization of Radiation Toxins Vaccination with the ARV significantly extended the survival time after irradiation with heavy ions from two hours up to 300 hours Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Clinical signs clinical features symptoms were somewhat
attenuated Degree of clinical forms of the Acute Radiation Syndromes were diminished in their severity Groups A-D demonstrated an extremely severe degree (Degree 4) of Cerebrovascular and Cardiovascular forms of the Acute Radiation Syndromes and lethality 100 was registered in a short time after irradiation Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Radi-ation induced burns in this groups (with
Cutaneous sub-syndrome of ARS -Degree 4) that were deep with extensive and total dysfunction and possible muscle involvement developed Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Animals from group E -Radioprotectant -anti-radiation vaccine
had demonstrated later development of the severe Degree 3 or even Degree 2-3 forms of Cerebrovascular and Cardiovascular forms of the ARS and a survival time of irradiated animals was significantly prolonged Cutaneous sub-syndrome developed in Degree 3 or Degree 2-3 Our results have demonstrated the potential radioprotection efficacy of specific immune-prophylaxis with the Antiradiation vaccine against heavy ion irradiation Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Space Radiation Life Sci Space Res 197513187-93
Peculiarities of biological action of hadrons of space radiation
Akoev IG1 Yurov SS
Biological investigations in space enable one to make a significant contribution on high-energy hadrons to biological effects under the influence of factors of space flights Physical and molecular principles of the action of high-energy hadrons are analysed Genetic and somatic hadron effects produced by the secondary radiation from 70 GeV protons have been studied experimentally The high biological effectiveness of hadrons great variability in biological effects and specifically of their action are associated with strong interactions of high-energy hadrons These are the probability of nuclear interaction with any atom nucleus generation of a great number of secondary particles (among them probably highly effective multicharged and heavy nuclei antiprotons pi(-)-mesons) and the spatial distribution of secondary particles as a narrow cone with extremely high density of particles in its first part The secondary radiation generated by high- and superhigh-energy hadrons upon their interaction with the spaceship is likely to be the greatest hazard of radiation to the crew during space flights
Hadrons Radiation Protection Introduction An anti-radiation vaccine could be an
important part of a countermeasures reg-imen for effective radioprotection immunoprophylaxis and immunotherapy of the acute radi-ation syndromes (ARS) after gamma-irradiation neutron irradiation or heavy ion irradiation Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Reliable protection of non-neoplastic regions of patients with
different forms of cancer which undergo to heavy ion therapy (
eg Hadron-therapy) can significantly extend the efficiency of the
therapeutic course The protection of cosmonauts astronauts
from the heavy ion radiation component of space radiation with
specific immunoprophylaxis by the anti-radiation vaccine may be
an important part of medical management for long term space
missions
Antiradiation vaccine Technology and development of
prophylaxis prevention and treatment of biological
consequences from Heavy Ion irradiation Available from
httpswwwresearchgatenetpublication253267437_Antiradiatio
n_vaccine_Technology_and_development_of_prophylaxis_preve
ntion_and_treatment_of_biological_consequences_from_Heavy_
Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Methods and experiments
1 The Antiradiation Vaccine preparation -standard (mixture of toxoid form of Radiation Toxins -SRD-group) which include Cerebrovascular RT - Neurotoxin Cardiovascular RT - Neurotoxin Gastrointestinal RT - Neurotoxin Hematopoietic RT - Hematotoxin Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Radiation Toxins Specific Radiation Determinant
Group were isolated from a central lymph of gamma-irradiated animals with Cerebrovascular Cardiovascular Gastrointestiinal Hematopoi-eticforms of ARS Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Devices for gamma-radiation are Panorama
Puma 2 Heavy ion exposure was accomplished at Department of Scientific Research Institute of Nuclear Physics Dubna Russia Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection The heavy ions irradiation was generated in heavy ion
(Fe56) accelerator -UTI Heavy Ion linear transfer energy -2000-2600 KeV mkm 600 MeV U Absorbed Dose -3820 Rad Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Experimental Design Rabbits from all groups were irradiated by
heavy ion accelerator Group A -control -10 rabbits Group B -placebo -5 rabbits Group C -radioprotectant Cystamine (50 mg kg)-5 rabbits 15 minutes before irradiation -5 rabbits Group D -radioprotectant Gammafos (Amifostine -400mg kg ) -5 rabbits Group E -Antiradiation Vaccine subcutaneus administration or IM -2 ml of active substance 14 days before irradiation - 5 rabbits Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Results Group A -100 mortality within two hours after
heavy ion irradiation with clinical symptoms of the acute cerebrovascular and cardiovascular syndromes Group B -100 mortal-ity within 15 hours following irradiation Group C -100 mortality within 14-15 hours after irradiation Group D -100 mortality within 15-16 hours after irradiation Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection In groups A-D development of the acute radiation
cerebrovascular and cardiovascular syndromes as well as ex-tensive burns of skin caused rapid death Group E -100 mortality in 280-290 hours (12 days) following heavy ion irradiation while animals were exhibiting a combination or individual forms of the acute cerebrovascular cardiovascular and gastrointestinal forms and focal skin burns Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Discussion The Antiradiation Vaccine (ARV) and
specific immune-prophylaxis are an effective method of neutralization of Radiation Toxins Vaccination with the ARV significantly extended the survival time after irradiation with heavy ions from two hours up to 300 hours Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Clinical signs clinical features symptoms were somewhat
attenuated Degree of clinical forms of the Acute Radiation Syndromes were diminished in their severity Groups A-D demonstrated an extremely severe degree (Degree 4) of Cerebrovascular and Cardiovascular forms of the Acute Radiation Syndromes and lethality 100 was registered in a short time after irradiation Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Radi-ation induced burns in this groups (with
Cutaneous sub-syndrome of ARS -Degree 4) that were deep with extensive and total dysfunction and possible muscle involvement developed Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Animals from group E -Radioprotectant -anti-radiation vaccine
had demonstrated later development of the severe Degree 3 or even Degree 2-3 forms of Cerebrovascular and Cardiovascular forms of the ARS and a survival time of irradiated animals was significantly prolonged Cutaneous sub-syndrome developed in Degree 3 or Degree 2-3 Our results have demonstrated the potential radioprotection efficacy of specific immune-prophylaxis with the Antiradiation vaccine against heavy ion irradiation Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Introduction An anti-radiation vaccine could be an
important part of a countermeasures reg-imen for effective radioprotection immunoprophylaxis and immunotherapy of the acute radi-ation syndromes (ARS) after gamma-irradiation neutron irradiation or heavy ion irradiation Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Reliable protection of non-neoplastic regions of patients with
different forms of cancer which undergo to heavy ion therapy (
eg Hadron-therapy) can significantly extend the efficiency of the
therapeutic course The protection of cosmonauts astronauts
from the heavy ion radiation component of space radiation with
specific immunoprophylaxis by the anti-radiation vaccine may be
an important part of medical management for long term space
missions
Antiradiation vaccine Technology and development of
prophylaxis prevention and treatment of biological
consequences from Heavy Ion irradiation Available from
httpswwwresearchgatenetpublication253267437_Antiradiatio
n_vaccine_Technology_and_development_of_prophylaxis_preve
ntion_and_treatment_of_biological_consequences_from_Heavy_
Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Methods and experiments
1 The Antiradiation Vaccine preparation -standard (mixture of toxoid form of Radiation Toxins -SRD-group) which include Cerebrovascular RT - Neurotoxin Cardiovascular RT - Neurotoxin Gastrointestinal RT - Neurotoxin Hematopoietic RT - Hematotoxin Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Radiation Toxins Specific Radiation Determinant
Group were isolated from a central lymph of gamma-irradiated animals with Cerebrovascular Cardiovascular Gastrointestiinal Hematopoi-eticforms of ARS Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Devices for gamma-radiation are Panorama
Puma 2 Heavy ion exposure was accomplished at Department of Scientific Research Institute of Nuclear Physics Dubna Russia Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection The heavy ions irradiation was generated in heavy ion
(Fe56) accelerator -UTI Heavy Ion linear transfer energy -2000-2600 KeV mkm 600 MeV U Absorbed Dose -3820 Rad Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Experimental Design Rabbits from all groups were irradiated by
heavy ion accelerator Group A -control -10 rabbits Group B -placebo -5 rabbits Group C -radioprotectant Cystamine (50 mg kg)-5 rabbits 15 minutes before irradiation -5 rabbits Group D -radioprotectant Gammafos (Amifostine -400mg kg ) -5 rabbits Group E -Antiradiation Vaccine subcutaneus administration or IM -2 ml of active substance 14 days before irradiation - 5 rabbits Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Results Group A -100 mortality within two hours after
heavy ion irradiation with clinical symptoms of the acute cerebrovascular and cardiovascular syndromes Group B -100 mortal-ity within 15 hours following irradiation Group C -100 mortality within 14-15 hours after irradiation Group D -100 mortality within 15-16 hours after irradiation Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection In groups A-D development of the acute radiation
cerebrovascular and cardiovascular syndromes as well as ex-tensive burns of skin caused rapid death Group E -100 mortality in 280-290 hours (12 days) following heavy ion irradiation while animals were exhibiting a combination or individual forms of the acute cerebrovascular cardiovascular and gastrointestinal forms and focal skin burns Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Discussion The Antiradiation Vaccine (ARV) and
specific immune-prophylaxis are an effective method of neutralization of Radiation Toxins Vaccination with the ARV significantly extended the survival time after irradiation with heavy ions from two hours up to 300 hours Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Clinical signs clinical features symptoms were somewhat
attenuated Degree of clinical forms of the Acute Radiation Syndromes were diminished in their severity Groups A-D demonstrated an extremely severe degree (Degree 4) of Cerebrovascular and Cardiovascular forms of the Acute Radiation Syndromes and lethality 100 was registered in a short time after irradiation Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Radi-ation induced burns in this groups (with
Cutaneous sub-syndrome of ARS -Degree 4) that were deep with extensive and total dysfunction and possible muscle involvement developed Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Animals from group E -Radioprotectant -anti-radiation vaccine
had demonstrated later development of the severe Degree 3 or even Degree 2-3 forms of Cerebrovascular and Cardiovascular forms of the ARS and a survival time of irradiated animals was significantly prolonged Cutaneous sub-syndrome developed in Degree 3 or Degree 2-3 Our results have demonstrated the potential radioprotection efficacy of specific immune-prophylaxis with the Antiradiation vaccine against heavy ion irradiation Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Reliable protection of non-neoplastic regions of patients with
different forms of cancer which undergo to heavy ion therapy (
eg Hadron-therapy) can significantly extend the efficiency of the
therapeutic course The protection of cosmonauts astronauts
from the heavy ion radiation component of space radiation with
specific immunoprophylaxis by the anti-radiation vaccine may be
an important part of medical management for long term space
missions
Antiradiation vaccine Technology and development of
prophylaxis prevention and treatment of biological
consequences from Heavy Ion irradiation Available from
httpswwwresearchgatenetpublication253267437_Antiradiatio
n_vaccine_Technology_and_development_of_prophylaxis_preve
ntion_and_treatment_of_biological_consequences_from_Heavy_
Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Methods and experiments
1 The Antiradiation Vaccine preparation -standard (mixture of toxoid form of Radiation Toxins -SRD-group) which include Cerebrovascular RT - Neurotoxin Cardiovascular RT - Neurotoxin Gastrointestinal RT - Neurotoxin Hematopoietic RT - Hematotoxin Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Radiation Toxins Specific Radiation Determinant
Group were isolated from a central lymph of gamma-irradiated animals with Cerebrovascular Cardiovascular Gastrointestiinal Hematopoi-eticforms of ARS Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Devices for gamma-radiation are Panorama
Puma 2 Heavy ion exposure was accomplished at Department of Scientific Research Institute of Nuclear Physics Dubna Russia Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection The heavy ions irradiation was generated in heavy ion
(Fe56) accelerator -UTI Heavy Ion linear transfer energy -2000-2600 KeV mkm 600 MeV U Absorbed Dose -3820 Rad Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Experimental Design Rabbits from all groups were irradiated by
heavy ion accelerator Group A -control -10 rabbits Group B -placebo -5 rabbits Group C -radioprotectant Cystamine (50 mg kg)-5 rabbits 15 minutes before irradiation -5 rabbits Group D -radioprotectant Gammafos (Amifostine -400mg kg ) -5 rabbits Group E -Antiradiation Vaccine subcutaneus administration or IM -2 ml of active substance 14 days before irradiation - 5 rabbits Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Results Group A -100 mortality within two hours after
heavy ion irradiation with clinical symptoms of the acute cerebrovascular and cardiovascular syndromes Group B -100 mortal-ity within 15 hours following irradiation Group C -100 mortality within 14-15 hours after irradiation Group D -100 mortality within 15-16 hours after irradiation Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection In groups A-D development of the acute radiation
cerebrovascular and cardiovascular syndromes as well as ex-tensive burns of skin caused rapid death Group E -100 mortality in 280-290 hours (12 days) following heavy ion irradiation while animals were exhibiting a combination or individual forms of the acute cerebrovascular cardiovascular and gastrointestinal forms and focal skin burns Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Discussion The Antiradiation Vaccine (ARV) and
specific immune-prophylaxis are an effective method of neutralization of Radiation Toxins Vaccination with the ARV significantly extended the survival time after irradiation with heavy ions from two hours up to 300 hours Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Clinical signs clinical features symptoms were somewhat
attenuated Degree of clinical forms of the Acute Radiation Syndromes were diminished in their severity Groups A-D demonstrated an extremely severe degree (Degree 4) of Cerebrovascular and Cardiovascular forms of the Acute Radiation Syndromes and lethality 100 was registered in a short time after irradiation Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Radi-ation induced burns in this groups (with
Cutaneous sub-syndrome of ARS -Degree 4) that were deep with extensive and total dysfunction and possible muscle involvement developed Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Animals from group E -Radioprotectant -anti-radiation vaccine
had demonstrated later development of the severe Degree 3 or even Degree 2-3 forms of Cerebrovascular and Cardiovascular forms of the ARS and a survival time of irradiated animals was significantly prolonged Cutaneous sub-syndrome developed in Degree 3 or Degree 2-3 Our results have demonstrated the potential radioprotection efficacy of specific immune-prophylaxis with the Antiradiation vaccine against heavy ion irradiation Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Methods and experiments
1 The Antiradiation Vaccine preparation -standard (mixture of toxoid form of Radiation Toxins -SRD-group) which include Cerebrovascular RT - Neurotoxin Cardiovascular RT - Neurotoxin Gastrointestinal RT - Neurotoxin Hematopoietic RT - Hematotoxin Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Radiation Toxins Specific Radiation Determinant
Group were isolated from a central lymph of gamma-irradiated animals with Cerebrovascular Cardiovascular Gastrointestiinal Hematopoi-eticforms of ARS Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Devices for gamma-radiation are Panorama
Puma 2 Heavy ion exposure was accomplished at Department of Scientific Research Institute of Nuclear Physics Dubna Russia Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection The heavy ions irradiation was generated in heavy ion
(Fe56) accelerator -UTI Heavy Ion linear transfer energy -2000-2600 KeV mkm 600 MeV U Absorbed Dose -3820 Rad Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Experimental Design Rabbits from all groups were irradiated by
heavy ion accelerator Group A -control -10 rabbits Group B -placebo -5 rabbits Group C -radioprotectant Cystamine (50 mg kg)-5 rabbits 15 minutes before irradiation -5 rabbits Group D -radioprotectant Gammafos (Amifostine -400mg kg ) -5 rabbits Group E -Antiradiation Vaccine subcutaneus administration or IM -2 ml of active substance 14 days before irradiation - 5 rabbits Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Results Group A -100 mortality within two hours after
heavy ion irradiation with clinical symptoms of the acute cerebrovascular and cardiovascular syndromes Group B -100 mortal-ity within 15 hours following irradiation Group C -100 mortality within 14-15 hours after irradiation Group D -100 mortality within 15-16 hours after irradiation Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection In groups A-D development of the acute radiation
cerebrovascular and cardiovascular syndromes as well as ex-tensive burns of skin caused rapid death Group E -100 mortality in 280-290 hours (12 days) following heavy ion irradiation while animals were exhibiting a combination or individual forms of the acute cerebrovascular cardiovascular and gastrointestinal forms and focal skin burns Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Discussion The Antiradiation Vaccine (ARV) and
specific immune-prophylaxis are an effective method of neutralization of Radiation Toxins Vaccination with the ARV significantly extended the survival time after irradiation with heavy ions from two hours up to 300 hours Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Clinical signs clinical features symptoms were somewhat
attenuated Degree of clinical forms of the Acute Radiation Syndromes were diminished in their severity Groups A-D demonstrated an extremely severe degree (Degree 4) of Cerebrovascular and Cardiovascular forms of the Acute Radiation Syndromes and lethality 100 was registered in a short time after irradiation Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Radi-ation induced burns in this groups (with
Cutaneous sub-syndrome of ARS -Degree 4) that were deep with extensive and total dysfunction and possible muscle involvement developed Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Animals from group E -Radioprotectant -anti-radiation vaccine
had demonstrated later development of the severe Degree 3 or even Degree 2-3 forms of Cerebrovascular and Cardiovascular forms of the ARS and a survival time of irradiated animals was significantly prolonged Cutaneous sub-syndrome developed in Degree 3 or Degree 2-3 Our results have demonstrated the potential radioprotection efficacy of specific immune-prophylaxis with the Antiradiation vaccine against heavy ion irradiation Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Radiation Toxins Specific Radiation Determinant
Group were isolated from a central lymph of gamma-irradiated animals with Cerebrovascular Cardiovascular Gastrointestiinal Hematopoi-eticforms of ARS Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Devices for gamma-radiation are Panorama
Puma 2 Heavy ion exposure was accomplished at Department of Scientific Research Institute of Nuclear Physics Dubna Russia Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection The heavy ions irradiation was generated in heavy ion
(Fe56) accelerator -UTI Heavy Ion linear transfer energy -2000-2600 KeV mkm 600 MeV U Absorbed Dose -3820 Rad Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Experimental Design Rabbits from all groups were irradiated by
heavy ion accelerator Group A -control -10 rabbits Group B -placebo -5 rabbits Group C -radioprotectant Cystamine (50 mg kg)-5 rabbits 15 minutes before irradiation -5 rabbits Group D -radioprotectant Gammafos (Amifostine -400mg kg ) -5 rabbits Group E -Antiradiation Vaccine subcutaneus administration or IM -2 ml of active substance 14 days before irradiation - 5 rabbits Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Results Group A -100 mortality within two hours after
heavy ion irradiation with clinical symptoms of the acute cerebrovascular and cardiovascular syndromes Group B -100 mortal-ity within 15 hours following irradiation Group C -100 mortality within 14-15 hours after irradiation Group D -100 mortality within 15-16 hours after irradiation Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection In groups A-D development of the acute radiation
cerebrovascular and cardiovascular syndromes as well as ex-tensive burns of skin caused rapid death Group E -100 mortality in 280-290 hours (12 days) following heavy ion irradiation while animals were exhibiting a combination or individual forms of the acute cerebrovascular cardiovascular and gastrointestinal forms and focal skin burns Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Discussion The Antiradiation Vaccine (ARV) and
specific immune-prophylaxis are an effective method of neutralization of Radiation Toxins Vaccination with the ARV significantly extended the survival time after irradiation with heavy ions from two hours up to 300 hours Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Clinical signs clinical features symptoms were somewhat
attenuated Degree of clinical forms of the Acute Radiation Syndromes were diminished in their severity Groups A-D demonstrated an extremely severe degree (Degree 4) of Cerebrovascular and Cardiovascular forms of the Acute Radiation Syndromes and lethality 100 was registered in a short time after irradiation Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Radi-ation induced burns in this groups (with
Cutaneous sub-syndrome of ARS -Degree 4) that were deep with extensive and total dysfunction and possible muscle involvement developed Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Animals from group E -Radioprotectant -anti-radiation vaccine
had demonstrated later development of the severe Degree 3 or even Degree 2-3 forms of Cerebrovascular and Cardiovascular forms of the ARS and a survival time of irradiated animals was significantly prolonged Cutaneous sub-syndrome developed in Degree 3 or Degree 2-3 Our results have demonstrated the potential radioprotection efficacy of specific immune-prophylaxis with the Antiradiation vaccine against heavy ion irradiation Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Devices for gamma-radiation are Panorama
Puma 2 Heavy ion exposure was accomplished at Department of Scientific Research Institute of Nuclear Physics Dubna Russia Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection The heavy ions irradiation was generated in heavy ion
(Fe56) accelerator -UTI Heavy Ion linear transfer energy -2000-2600 KeV mkm 600 MeV U Absorbed Dose -3820 Rad Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Experimental Design Rabbits from all groups were irradiated by
heavy ion accelerator Group A -control -10 rabbits Group B -placebo -5 rabbits Group C -radioprotectant Cystamine (50 mg kg)-5 rabbits 15 minutes before irradiation -5 rabbits Group D -radioprotectant Gammafos (Amifostine -400mg kg ) -5 rabbits Group E -Antiradiation Vaccine subcutaneus administration or IM -2 ml of active substance 14 days before irradiation - 5 rabbits Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Results Group A -100 mortality within two hours after
heavy ion irradiation with clinical symptoms of the acute cerebrovascular and cardiovascular syndromes Group B -100 mortal-ity within 15 hours following irradiation Group C -100 mortality within 14-15 hours after irradiation Group D -100 mortality within 15-16 hours after irradiation Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection In groups A-D development of the acute radiation
cerebrovascular and cardiovascular syndromes as well as ex-tensive burns of skin caused rapid death Group E -100 mortality in 280-290 hours (12 days) following heavy ion irradiation while animals were exhibiting a combination or individual forms of the acute cerebrovascular cardiovascular and gastrointestinal forms and focal skin burns Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Discussion The Antiradiation Vaccine (ARV) and
specific immune-prophylaxis are an effective method of neutralization of Radiation Toxins Vaccination with the ARV significantly extended the survival time after irradiation with heavy ions from two hours up to 300 hours Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Clinical signs clinical features symptoms were somewhat
attenuated Degree of clinical forms of the Acute Radiation Syndromes were diminished in their severity Groups A-D demonstrated an extremely severe degree (Degree 4) of Cerebrovascular and Cardiovascular forms of the Acute Radiation Syndromes and lethality 100 was registered in a short time after irradiation Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Radi-ation induced burns in this groups (with
Cutaneous sub-syndrome of ARS -Degree 4) that were deep with extensive and total dysfunction and possible muscle involvement developed Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Animals from group E -Radioprotectant -anti-radiation vaccine
had demonstrated later development of the severe Degree 3 or even Degree 2-3 forms of Cerebrovascular and Cardiovascular forms of the ARS and a survival time of irradiated animals was significantly prolonged Cutaneous sub-syndrome developed in Degree 3 or Degree 2-3 Our results have demonstrated the potential radioprotection efficacy of specific immune-prophylaxis with the Antiradiation vaccine against heavy ion irradiation Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection The heavy ions irradiation was generated in heavy ion
(Fe56) accelerator -UTI Heavy Ion linear transfer energy -2000-2600 KeV mkm 600 MeV U Absorbed Dose -3820 Rad Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Experimental Design Rabbits from all groups were irradiated by
heavy ion accelerator Group A -control -10 rabbits Group B -placebo -5 rabbits Group C -radioprotectant Cystamine (50 mg kg)-5 rabbits 15 minutes before irradiation -5 rabbits Group D -radioprotectant Gammafos (Amifostine -400mg kg ) -5 rabbits Group E -Antiradiation Vaccine subcutaneus administration or IM -2 ml of active substance 14 days before irradiation - 5 rabbits Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Results Group A -100 mortality within two hours after
heavy ion irradiation with clinical symptoms of the acute cerebrovascular and cardiovascular syndromes Group B -100 mortal-ity within 15 hours following irradiation Group C -100 mortality within 14-15 hours after irradiation Group D -100 mortality within 15-16 hours after irradiation Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection In groups A-D development of the acute radiation
cerebrovascular and cardiovascular syndromes as well as ex-tensive burns of skin caused rapid death Group E -100 mortality in 280-290 hours (12 days) following heavy ion irradiation while animals were exhibiting a combination or individual forms of the acute cerebrovascular cardiovascular and gastrointestinal forms and focal skin burns Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Discussion The Antiradiation Vaccine (ARV) and
specific immune-prophylaxis are an effective method of neutralization of Radiation Toxins Vaccination with the ARV significantly extended the survival time after irradiation with heavy ions from two hours up to 300 hours Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Clinical signs clinical features symptoms were somewhat
attenuated Degree of clinical forms of the Acute Radiation Syndromes were diminished in their severity Groups A-D demonstrated an extremely severe degree (Degree 4) of Cerebrovascular and Cardiovascular forms of the Acute Radiation Syndromes and lethality 100 was registered in a short time after irradiation Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Radi-ation induced burns in this groups (with
Cutaneous sub-syndrome of ARS -Degree 4) that were deep with extensive and total dysfunction and possible muscle involvement developed Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Animals from group E -Radioprotectant -anti-radiation vaccine
had demonstrated later development of the severe Degree 3 or even Degree 2-3 forms of Cerebrovascular and Cardiovascular forms of the ARS and a survival time of irradiated animals was significantly prolonged Cutaneous sub-syndrome developed in Degree 3 or Degree 2-3 Our results have demonstrated the potential radioprotection efficacy of specific immune-prophylaxis with the Antiradiation vaccine against heavy ion irradiation Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Experimental Design Rabbits from all groups were irradiated by
heavy ion accelerator Group A -control -10 rabbits Group B -placebo -5 rabbits Group C -radioprotectant Cystamine (50 mg kg)-5 rabbits 15 minutes before irradiation -5 rabbits Group D -radioprotectant Gammafos (Amifostine -400mg kg ) -5 rabbits Group E -Antiradiation Vaccine subcutaneus administration or IM -2 ml of active substance 14 days before irradiation - 5 rabbits Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Results Group A -100 mortality within two hours after
heavy ion irradiation with clinical symptoms of the acute cerebrovascular and cardiovascular syndromes Group B -100 mortal-ity within 15 hours following irradiation Group C -100 mortality within 14-15 hours after irradiation Group D -100 mortality within 15-16 hours after irradiation Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection In groups A-D development of the acute radiation
cerebrovascular and cardiovascular syndromes as well as ex-tensive burns of skin caused rapid death Group E -100 mortality in 280-290 hours (12 days) following heavy ion irradiation while animals were exhibiting a combination or individual forms of the acute cerebrovascular cardiovascular and gastrointestinal forms and focal skin burns Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Discussion The Antiradiation Vaccine (ARV) and
specific immune-prophylaxis are an effective method of neutralization of Radiation Toxins Vaccination with the ARV significantly extended the survival time after irradiation with heavy ions from two hours up to 300 hours Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Clinical signs clinical features symptoms were somewhat
attenuated Degree of clinical forms of the Acute Radiation Syndromes were diminished in their severity Groups A-D demonstrated an extremely severe degree (Degree 4) of Cerebrovascular and Cardiovascular forms of the Acute Radiation Syndromes and lethality 100 was registered in a short time after irradiation Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Radi-ation induced burns in this groups (with
Cutaneous sub-syndrome of ARS -Degree 4) that were deep with extensive and total dysfunction and possible muscle involvement developed Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Animals from group E -Radioprotectant -anti-radiation vaccine
had demonstrated later development of the severe Degree 3 or even Degree 2-3 forms of Cerebrovascular and Cardiovascular forms of the ARS and a survival time of irradiated animals was significantly prolonged Cutaneous sub-syndrome developed in Degree 3 or Degree 2-3 Our results have demonstrated the potential radioprotection efficacy of specific immune-prophylaxis with the Antiradiation vaccine against heavy ion irradiation Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Results Group A -100 mortality within two hours after
heavy ion irradiation with clinical symptoms of the acute cerebrovascular and cardiovascular syndromes Group B -100 mortal-ity within 15 hours following irradiation Group C -100 mortality within 14-15 hours after irradiation Group D -100 mortality within 15-16 hours after irradiation Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection In groups A-D development of the acute radiation
cerebrovascular and cardiovascular syndromes as well as ex-tensive burns of skin caused rapid death Group E -100 mortality in 280-290 hours (12 days) following heavy ion irradiation while animals were exhibiting a combination or individual forms of the acute cerebrovascular cardiovascular and gastrointestinal forms and focal skin burns Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Discussion The Antiradiation Vaccine (ARV) and
specific immune-prophylaxis are an effective method of neutralization of Radiation Toxins Vaccination with the ARV significantly extended the survival time after irradiation with heavy ions from two hours up to 300 hours Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Clinical signs clinical features symptoms were somewhat
attenuated Degree of clinical forms of the Acute Radiation Syndromes were diminished in their severity Groups A-D demonstrated an extremely severe degree (Degree 4) of Cerebrovascular and Cardiovascular forms of the Acute Radiation Syndromes and lethality 100 was registered in a short time after irradiation Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Radi-ation induced burns in this groups (with
Cutaneous sub-syndrome of ARS -Degree 4) that were deep with extensive and total dysfunction and possible muscle involvement developed Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Animals from group E -Radioprotectant -anti-radiation vaccine
had demonstrated later development of the severe Degree 3 or even Degree 2-3 forms of Cerebrovascular and Cardiovascular forms of the ARS and a survival time of irradiated animals was significantly prolonged Cutaneous sub-syndrome developed in Degree 3 or Degree 2-3 Our results have demonstrated the potential radioprotection efficacy of specific immune-prophylaxis with the Antiradiation vaccine against heavy ion irradiation Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection In groups A-D development of the acute radiation
cerebrovascular and cardiovascular syndromes as well as ex-tensive burns of skin caused rapid death Group E -100 mortality in 280-290 hours (12 days) following heavy ion irradiation while animals were exhibiting a combination or individual forms of the acute cerebrovascular cardiovascular and gastrointestinal forms and focal skin burns Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Discussion The Antiradiation Vaccine (ARV) and
specific immune-prophylaxis are an effective method of neutralization of Radiation Toxins Vaccination with the ARV significantly extended the survival time after irradiation with heavy ions from two hours up to 300 hours Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Clinical signs clinical features symptoms were somewhat
attenuated Degree of clinical forms of the Acute Radiation Syndromes were diminished in their severity Groups A-D demonstrated an extremely severe degree (Degree 4) of Cerebrovascular and Cardiovascular forms of the Acute Radiation Syndromes and lethality 100 was registered in a short time after irradiation Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Radi-ation induced burns in this groups (with
Cutaneous sub-syndrome of ARS -Degree 4) that were deep with extensive and total dysfunction and possible muscle involvement developed Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Animals from group E -Radioprotectant -anti-radiation vaccine
had demonstrated later development of the severe Degree 3 or even Degree 2-3 forms of Cerebrovascular and Cardiovascular forms of the ARS and a survival time of irradiated animals was significantly prolonged Cutaneous sub-syndrome developed in Degree 3 or Degree 2-3 Our results have demonstrated the potential radioprotection efficacy of specific immune-prophylaxis with the Antiradiation vaccine against heavy ion irradiation Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Discussion The Antiradiation Vaccine (ARV) and
specific immune-prophylaxis are an effective method of neutralization of Radiation Toxins Vaccination with the ARV significantly extended the survival time after irradiation with heavy ions from two hours up to 300 hours Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Clinical signs clinical features symptoms were somewhat
attenuated Degree of clinical forms of the Acute Radiation Syndromes were diminished in their severity Groups A-D demonstrated an extremely severe degree (Degree 4) of Cerebrovascular and Cardiovascular forms of the Acute Radiation Syndromes and lethality 100 was registered in a short time after irradiation Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Radi-ation induced burns in this groups (with
Cutaneous sub-syndrome of ARS -Degree 4) that were deep with extensive and total dysfunction and possible muscle involvement developed Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Animals from group E -Radioprotectant -anti-radiation vaccine
had demonstrated later development of the severe Degree 3 or even Degree 2-3 forms of Cerebrovascular and Cardiovascular forms of the ARS and a survival time of irradiated animals was significantly prolonged Cutaneous sub-syndrome developed in Degree 3 or Degree 2-3 Our results have demonstrated the potential radioprotection efficacy of specific immune-prophylaxis with the Antiradiation vaccine against heavy ion irradiation Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Clinical signs clinical features symptoms were somewhat
attenuated Degree of clinical forms of the Acute Radiation Syndromes were diminished in their severity Groups A-D demonstrated an extremely severe degree (Degree 4) of Cerebrovascular and Cardiovascular forms of the Acute Radiation Syndromes and lethality 100 was registered in a short time after irradiation Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Radi-ation induced burns in this groups (with
Cutaneous sub-syndrome of ARS -Degree 4) that were deep with extensive and total dysfunction and possible muscle involvement developed Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Animals from group E -Radioprotectant -anti-radiation vaccine
had demonstrated later development of the severe Degree 3 or even Degree 2-3 forms of Cerebrovascular and Cardiovascular forms of the ARS and a survival time of irradiated animals was significantly prolonged Cutaneous sub-syndrome developed in Degree 3 or Degree 2-3 Our results have demonstrated the potential radioprotection efficacy of specific immune-prophylaxis with the Antiradiation vaccine against heavy ion irradiation Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Radi-ation induced burns in this groups (with
Cutaneous sub-syndrome of ARS -Degree 4) that were deep with extensive and total dysfunction and possible muscle involvement developed Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation[accessed Apr 12 2015]
Hadrons Radiation Protection Animals from group E -Radioprotectant -anti-radiation vaccine
had demonstrated later development of the severe Degree 3 or even Degree 2-3 forms of Cerebrovascular and Cardiovascular forms of the ARS and a survival time of irradiated animals was significantly prolonged Cutaneous sub-syndrome developed in Degree 3 or Degree 2-3 Our results have demonstrated the potential radioprotection efficacy of specific immune-prophylaxis with the Antiradiation vaccine against heavy ion irradiation Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
Hadrons Radiation Protection Animals from group E -Radioprotectant -anti-radiation vaccine
had demonstrated later development of the severe Degree 3 or even Degree 2-3 forms of Cerebrovascular and Cardiovascular forms of the ARS and a survival time of irradiated animals was significantly prolonged Cutaneous sub-syndrome developed in Degree 3 or Degree 2-3 Our results have demonstrated the potential radioprotection efficacy of specific immune-prophylaxis with the Antiradiation vaccine against heavy ion irradiation Antiradiation vaccine Technology and development of prophylaxis prevention and treatment of biological consequences from Heavy Ion irradiation Available from httpswwwresearchgatenetpublication253267437_Antiradiation_vaccine_Technology_and_development_of_prophylaxis_prevention_and_treatment_of_biological_consequences_from_Heavy_Ion_irradiation [accessed Apr 12 2015]
