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DISORDERS OF THE EYELIDS 2
Dr Russell J Watkins
Entropion Types
Involutional Cicatricial Acute spastic
Involutional Entropion Affects lower lid Possible pathological mechanisms are:
Preseptal portion overrides pretarsal portion of orbicularis oculi
Horizontal lid laxity due to stretched canthal tendons, orbital fat atrophy
Weakened tarsus allowing flexure Vertical instability due to dehiscence of
retractors
Involutional Entropion Treatment of involutional entropion
Taping Botulinum toxin if unfit for surgery Surgery
Cicatricial Entropion Affects upper or lower lid Scarring shortens posterior lamella Causes include trachoma, radiation, chemical
injury, topical rx, previous surgery, trauma, SJS & mucous membrane pemphigoid
Treatment is usually surgical
Acute Spastic Entropion Orbicularis oculi spasm due to ocular irritation or
essential blepharospasm Usually associated with involutional entropion Management is by removal of irritant, treatment
of associated involutional entropion, botulinum toxin
Ectropion Types of ectropion
Involutional Cictatricial Paralytic
Involutional Ectropion Usually lower lid Tarsal stretching ± orbicularis weakness Treatment is by cicatrising cautery or surgery
Cicatricial Ectropion Upper or lower lid Causes include trauma [lacerations, burns,
surgery], tumours, infections Optometric management - refer
Pay attention to prevention of exposure keratopathy
Surgical management aimed at release of scarring including skin grafts
Paralytic Ectropion Lower lid ±lagophthalmos Causes: myopathy; CN VII disorders Optometric management – refer
Pay attention to prevention of exposure keratopathy
Botulinum toxin induced ptosis; tarsorrhaphy Various other surgical techniques including nerve
transposition
Blepharospasm Involuntary tonic, spasmodic, bilateral eyelid
closure F>M More common in older individuals (60+ yrs) Causes - idiopathic, Parkinson’s disease,
psychogenic, post-encephalitic, tetany, drugs e.g. psychotropics
Treatment - botulinum toxin injections into orbicularis oculi
Floppy Lid Syndrome Generalised laxity of eyelid tissues Can be unilateral or bilateral Symptoms - ocular irritation, redness Signs - SPK, easy distraction of lid from globe,
easy upper lid eversion, lower lid ectropion, ptosis
Treatment - wedge excision, canthal tendon repair
Orbicularis Myokymia Involuntary contraction producing an annoying
twitching sensation Related to fatigue - a very common presentation
in optometric practice Rarely due to a sinister cause
Hemifacial spasm Multiple sclerosis
Benign Eyelid Tumours Xanthelasma
Fatty plaques (foam cells in epidermis), usually medial, usually bilateral
Associated with 1° hyperlipidaemic states, DM, hypothyroidism, primary biliary cirrhosis
Optometric management - refer to GP for exclusion of underlying cause
Surgical management - excision (60% recur), laser ablation, chemical cautery
Benign Eyelid Tumours Basal cell papilloma
Also known as seborrhoeic keratosis Common Sessile
Benign Eyelid Tumours Squamous cell papilloma
Common Sessile or pedunculated Histopathology - excessive convoluted
epithelium with central fibrovascular core; may form keratin horn
Benign Eyelid Tumours Solar keratosis
Flat, multiple, scaly lesions Occasionally papillomatous with keratin horn
formation NB: premalignant Histopathology - epithelial dysplasia with
keratosis BUT no invasion
Benign Eyelid Tumours Keratoacanthoma
Rapidly enlarges (months), then regresses Volcano shaped with keratin plug Visually, often difficult to distinguish from
BCC, whereas: Histopathology - difficult to differentiate from
SCC unless whole lesion examined; no invasion, but basal inflammation
Benign Eyelid Tumours Haemangioma
Strawberry naevus: evident in neonatal period Grows then usually regresses by 5yrs May be cutaneous, orbital or mixed Histopathology - capillary proliferation, some
of which are uncanalised
Benign Eyelid Tumours Neurofibroma
Associated with neurofibromatosis Histopathology - Schwann cell & fibroblast
proliferation
Benign Eyelid Tumours Naevi
Congenital collections of naevus cells Pigmented or non-pigmented May become pigmented post-puberty
Benign Eyelid Tumours Naevi are classified according to location
Epidermal - slightly thickened epithelium with naevus cells forming cysts
Junctional - activity at epidermal/dermal junction, occuring at puberty
Dermal - collections of naevus cells within the dermis; Can be associated with choroidal melanomas
Compound - malignant
Benign Eyelid Tumours Cyst of Moll
Retention cyst Clear & fluid filled
Cyst of Zeis Retention cyst White cheesy (sebaceous) material
Miscellaneous Benign Lumps Milia Cutaneous horn Meibomian cyst Naevus flammeus Dermoid cyst
Malignant Eyelid Tumours Basal cell carcinoma
Most common malignant carcinoma Lower lid most common site Do NOT metastasise but invade locally Types
• Noduloulcerative - well defined; Ulcerated & inflamed lesion
• Sclerosing (morphoea) - tends to be multifocal Optometric management - refer for cryo, RT or surgery
Malignant Eyelid Tumours Carcinoma in situ (Bowen’s disease)
5% of eyelid tumours Upper lid most common site Histopathology - dedifferentiation of epithelial
cells; localised to epidermis; premalignant for SCC
Malignant Eyelid Tumours Squamous cell carcinoma
Arise de novo from premalignant states such as solar keratoses & xeroderma pigmentosum
Lymphatogenous spread May evoke inflammatory response Histopathology can be from well differentiated
to anaplastic Optometric management - refer (radical
excision)
Malignant Eyelid Tumours Malignant melanoma
Very rare (of the eyelid) Can arise de novo or as a malignant
transformation of a junctional naevus Signs include itching, bleeding, pigmentary
changes, increase in size
Malignant Eyelid Tumours Types of malignant melanoma
Lentigo maligna - superficial, premalignant (seen in the elderly)
Superficial spreading melanoma Nodular - occurs only on covered areas not on
face Optometric management - refer Prognosis depends on site, depth of invasion
(poor if >1.5mm) & degree of inflammation
Malignant Eyelid Tumours Meibomian gland carcinoma
Rare Localised May present as recurrent chalazion Optometric management - refer (radical
excision & RT)
Miscellaneous Malignant Lumps
Metastatic deposit Lymphomatous infiltrate Sebaceous gland carcinoma Kaposi sarcoma