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Edema factor
Lethal factor
Protective antigen factor
Mal ignant pustule
(black eschar)
Nonpitting edema
Warfare
Hemorrhagic
meningoencephalitis
Hemorrhagic mediastinal
adenopathy
Oropharyngeal swelling
Septicemia (death)
Hemorrhagic diarrhea
Bacillus Anthracis
General Features
Pathogenesis
Lab Diagnosis
Types of Anthrax
Treatment
Prevention
Septum
Blood
CSF
Skin biopsy (PCR)
Medusa head
appearance
Gamma-
hemolytic Bamboo stick
appearance
Gram +ve
Factors Capsule
D-glutamic acid
Gram +ve bacilli
Gamma-
hemolytic
Cata lase positive
Causative agent
for Anthrax Vaccine with a lum adjuvant and protective
antigen Antibiotic
prophylaxis
Ciprofloxacin Doxycycl ine
Ri fampin
Penici l l in
Vancomycin, etc. +
Louis
Pasteur
Demonstrated
by R. Koch
Cutaneous Gastrointestinal
Inhalational
Vi rulence Factors
Specimen
Gram stain
Blood agar
Moti l ity test
Nonmotile
India Ink
Sta ining
Determining
stain
Anthrax = ‘coal’
(black eschar)
Endospores require
autoclaving to be destroyed
Edema factor acts as adenylate
cyclase, causing water and
electrolyte secretion from cell
Bacillus anthracis has
been used for
bioterrorism in the US
95% of anthrax cases in humans are cutaneous