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Research Services at a GlanceDr. Josef ScheiberGarmischer Str. 4/V80339 MünchenTel.: +49 89 / 1 89 65 82-80Fax: +49 89 / 1 89 65 82-99
w w w . b i o v a r i a n c e . d e
Overview and IntroductionAll our offerings are driven by our scientific context platform. It is the base for our data analyses, that combined with high-quality visualization capabilities form the two pillars of BioVariance‘s offering in the services area.
We turn complexity into usable data for drug development and thereby ensure that you can discuss and communicate the key parts of the results quickly within your project team.
(Back) Translating complex knowledge where Xenobiotics meet Human Biology
Data
Ana
lysis Side effects
ToxicityPathwaysSequences Vi
sual
izatio
ncomplex data
biological networks
Scientific context platform
PhenotypeDisease Xenobiotic
Data Analysis for Drug Discovery Translational Data Analysis ConsultingWithin this area we enrich all results with knowledge from our scientific context platform. (exemplified in this image are different biological reasons that can lead to the same out-come.)
We firmly believe that these additional information sources greatly facilitate your decision making when trying to understand compound effects, e.g. in clinical studies.
For this area we have a strong focus on exploiting knowledge about marketed drugs for earlier stages of Drug Discovery and always aim for testable hypotheses. You can contact us for our expertise in the following areas:
side effect and toxicity prediction (starting from chemical structures only, but we can also incorporate other data types)
linking biological pathways with additional phenotypes
start from an unwanted toxicity to develop a hypothesis for the reason
Polypharmacology profiles and chemogenomics analyses
By applying these methods BioVariance‘s clients take a quicker route to better lead compounds and clinical candidates.
With our consulting services BioVariance helps to identify the right informatics me-thods and tools to help you solving your scientific challenge. At the interface of Che-mistry and Biology we support you with the following points:
content selection to improve results and interpretation
simple visualization methods to improve understanding of complex data
broad network of vendors and academia to find the best tool, either open source or commercial.
Main focus areas are:
Tertiary NGS analysis (what do the results mean) Expression analysis Pathway based biomarkers finding additional possible indications Patient Stratification hypotheses for Companion Diagnostics
Knowledge
Enhanced analyses
and results
MarketedDrug
PreclinicalDevelopmentToxLead
FindingTarget
identification
SNP in Gene A affects affinity of
Protein modification affects phosphorylation
Food intake affects transcription factor
Epigenetic modification causes
is an off-target of drug Xthe patient is taking
a single phenotype, e.g. side effect
Straightforward visualization of the most relevant factsComplex Biomedical Interaction Data
